{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:18:45Z","timestamp":1790230725793,"version":"4.1.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500263"],"award-info":[{"award-number":["81500263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016T90973"],"award-info":[{"award-number":["2016T90973"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M572681"],"award-info":[{"award-number":["2015M572681"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.arr.2018.03.004","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T19:04:15Z","timestamp":1521831855000},"page":"8-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["PGC-1\u03b1 sparks the fire of neuroprotection against neurodegenerative disorders"],"prefix":"10.1016","volume":"44","author":[{"given":"Jianjun","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7150\/ijms.10035","article-title":"Astrocytes protect neurons from Abeta1-42 peptide-induced neurotoxicity increasing TFAM and PGC-1 and decreasing PPAR-gamma and SIRT-1","volume":"12","author":"Aguirre-Rueda","year":"2015","journal-title":"Int. J. Med. Sci."},{"issue":"11","key":"10.1016\/j.arr.2018.03.004_bib0010","doi-asserted-by":"crossref","first-page":"26417","DOI":"10.3390\/ijms161125961","article-title":"Alzheimer's disease: mechanism and approach to cell therapy","volume":"16","author":"Amemori","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2004.11.047","article-title":"Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease","volume":"132","author":"Aucoin","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2018.03.004_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1742-2094-2-21","article-title":"5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia","volume":"2","author":"Ayasolla","year":"2005","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2010.06.020","article-title":"Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol","volume":"480","author":"Binienda","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0035","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00990.x","article-title":"Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease","volume":"82","author":"Breidert","year":"2002","journal-title":"J. Neurochem."},{"issue":"22","key":"10.1016\/j.arr.2018.03.004_bib0040","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJM198505303122203","article-title":"The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)","volume":"312","author":"Burns","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2018.03.004_bib0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mcn.2012.11.011","article-title":"Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases","volume":"55","author":"Chaturvedi","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.arr.2018.03.004_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.03.018","article-title":"Mitochondrial diseases of the brain","volume":"63","author":"Chaturvedi","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"16","key":"10.1016\/j.arr.2018.03.004_bib0055","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1093\/hmg\/ddp243","article-title":"Impaired PGC-1alpha function in muscle in Huntington's disease","volume":"18","author":"Chaturvedi","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"16","key":"10.1016\/j.arr.2018.03.004_bib0060","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1093\/hmg\/ddq229","article-title":"Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation","volume":"19","author":"Chaturvedi","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"15","key":"10.1016\/j.arr.2018.03.004_bib0065","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1093\/hmg\/dds178","article-title":"Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease","volume":"21","author":"Chaturvedi","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-6-1","article-title":"Localization of sequence variations in PGC-1alpha influence their modifying effect in Huntington disease","volume":"6","author":"Che","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"14","key":"10.1016\/j.arr.2018.03.004_bib0075","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1002\/jnr.22469","volume":"88","author":"Chen","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12035-012-8259-8","article-title":"Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders","volume":"46","author":"Chen","year":"2012","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.arr.2018.03.004_bib0085","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbadis.2011.05.006","article-title":"The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease","volume":"1812","author":"Chiang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.arr.2018.03.004_bib0090","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1093\/hmg\/ddr618","article-title":"Sustained expression of PGC-1alpha in the rat nigrostriatal system selectively impairs dopaminergic function","volume":"21","author":"Ciron","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/ars.2008.2241","article-title":"Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease","volume":"11","author":"Clark","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2018.03.004_bib0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2350-12-69","article-title":"Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease","volume":"12","author":"Clark","year":"2011","journal-title":"BMC Med. Genet."},{"issue":"11","key":"10.1016\/j.arr.2018.03.004_bib0105","doi-asserted-by":"crossref","first-page":"e48925","DOI":"10.1371\/journal.pone.0048925","article-title":"Pgc-1alpha overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf","volume":"7","author":"Clark","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0110","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.molcel.2003.08.013","article-title":"TORCs: transducers of regulated CREB activity","volume":"12","author":"Conkright","year":"2003","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s11064-014-1377-0","article-title":"PPARgamma and PGC-1alpha as therapeutic targets in Parkinson's","volume":"40","author":"Corona","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2018.03.004_bib0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.expneurol.2013.12.012","article-title":"PPARgamma activation rescues mitochondrial function from inhibition of complex I and loss of PINK1","volume":"253","author":"Corona","year":"2014","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0130","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cmet.2012.03.019","article-title":"Elevated PGC-1alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS","volume":"15","author":"Da Cruz","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2018.03.004_bib0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.freeradbiomed.2013.01.018","article-title":"Parkinson disease: from pathology to molecular disease mechanisms","volume":"62","author":"Dexter","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2018.03.004_bib0140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.21775\/cimb.028.029","article-title":"PGC-1: the energetic regulator in cardiac metabolism","volume":"28","author":"Di","year":"2018","journal-title":"Curr. Issues Mol. Biol."},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0145","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015008","article-title":"Mitochondrial biogenesis through activation of nuclear signaling proteins","volume":"5","author":"Dominy","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"23","key":"10.1016\/j.arr.2018.03.004_bib0150","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1093\/hmg\/dds355","article-title":"Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice","volume":"21","author":"Dumont","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0155","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1096\/fj.13-236331","article-title":"PGC-1alpha overexpression exacerbates beta-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease","volume":"28","author":"Dumont","year":"2014","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ana.24294","article-title":"Mutual exacerbation of peroxisome proliferator-activated receptor gamma coactivator 1alpha deregulation and alpha-synuclein oligomerization","volume":"77","author":"Eschbach","year":"2015","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0165","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction","volume":"157","author":"Fang","year":"2014","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0170","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbadis.2014.02.010","article-title":"Effect of resveratrol on mitochondrial function: implications in parkin-associated familiar Parkinson's disease","volume":"1842","author":"Ferretta","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2018.03.004_bib0175","doi-asserted-by":"crossref","first-page":"324256","DOI":"10.1155\/2012\/324256","article-title":"Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes","volume":"2012","author":"Fujita","year":"2012","journal-title":"Oxid. Med. Cell Longev."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0180","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.semcdb.2012.01.007","article-title":"The diverse role of the PPARgamma coactivator 1 family of transcriptional coactivators in cancer","volume":"23","author":"Girnun","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2018.03.004_bib0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1478-811X-12-23","article-title":"Signaling pathway cross talk in Alzheimer's disease","volume":"12","author":"Godoy","year":"2014","journal-title":"Cell Commun. Signal."},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0190","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.neurobiolaging.2012.12.005","article-title":"Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models","volume":"34","author":"Gong","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nbd.2010.08.017","article-title":"Nicotinamide improves motor deficits and upregulates PGC-1alpha and BDNF gene expression in a mouse model of Huntington's disease","volume":"41","author":"Hathorn","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"6294","key":"10.1016\/j.arr.2018.03.004_bib0200","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/347645a0","article-title":"Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators","volume":"347","author":"Issemann","year":"1990","journal-title":"Nature"},{"issue":"29","key":"10.1016\/j.arr.2018.03.004_bib0205","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"Jager","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway","volume":"18","author":"Jeong","year":"2012","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0215","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets","volume":"18","author":"Jiang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2018.03.004_bib0220","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2017.07.001","article-title":"AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging","volume":"38","author":"Jiang","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0225","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jnc.12190","article-title":"Neuroprotective effects of PPAR-gamma agonist rosiglitazone in N171-82Q mouse model of Huntington's disease","volume":"125","author":"Jin","year":"2013","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0230","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1159\/000327910","article-title":"Truncated peroxisome proliferator-activated receptor-gamma coactivator 1alpha splice variant is severely altered in Huntington's disease","volume":"8","author":"Johri","year":"2011","journal-title":"Neurodegener. Dis."},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0235","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease","volume":"21","author":"Johri","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.201105010","article-title":"Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease","volume":"194","author":"Ju","year":"2011","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0245","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2005.11.177","article-title":"Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity","volume":"340","author":"Jung","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1\u20132","key":"10.1016\/j.arr.2018.03.004_bib0250","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mito.2006.11.017","article-title":"Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions","volume":"7","author":"Kang","year":"2007","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0255","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2011-101356","article-title":"PPARgamma co-activator-1alpha (PGC-1alpha) reduces amyloid-beta generation through a PPARgamma-dependent mechanism","volume":"25","author":"Katsouri","year":"2011","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0260","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.expneurol.2004.10.007","article-title":"Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis","volume":"191","author":"Kiaei","year":"2005","journal-title":"Exp. Neurol."},{"issue":"13","key":"10.1016\/j.arr.2018.03.004_bib0265","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"issue":"20","key":"10.1016\/j.arr.2018.03.004_bib0270","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0275","doi-asserted-by":"crossref","first-page":"e11707","DOI":"10.1371\/journal.pone.0011707","article-title":"Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis","volume":"5","author":"Kong","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0280","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0285","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biocel.2004.09.010","article-title":"Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress","volume":"37","author":"Lee","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0290","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pbio.0030101","article-title":"PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis","volume":"3","author":"Leone","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2018.03.004_bib0295","doi-asserted-by":"crossref","DOI":"10.1111\/bph.13966","article-title":"Melatonin: does it have utility in the treatment of haematological neoplasms?","author":"Li","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0300","first-page":"640","article-title":"p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons","volume":"88","author":"Liang","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0305","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/mus.22217","article-title":"PGC-1alpha protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model","volume":"44","author":"Liang","year":"2011","journal-title":"Muscle Nerve"},{"issue":"37","key":"10.1016\/j.arr.2018.03.004_bib0310","doi-asserted-by":"crossref","first-page":"62780","DOI":"10.18632\/oncotarget.19376","article-title":"AMPK: a novel target for treating hepatic fibrosis","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0315","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","article-title":"Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice","volume":"119","author":"Lin","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0320","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"issue":"1\u20132","key":"10.1016\/j.arr.2018.03.004_bib0325","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12031-009-9196-5","article-title":"NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation\/reperfusion injury","volume":"39","author":"Luo","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.arr.2018.03.004_bib0330","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pneurobio.2017.12.001","article-title":"Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke","volume":"161","author":"Lv","year":"2018","journal-title":"Prog. Neurobiol."},{"issue":"21","key":"10.1016\/j.arr.2018.03.004_bib0335","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1007\/s00018-017-2618-6","article-title":"Melatonin and mitochondrial function during ischemia\/reperfusion injury","volume":"74","author":"Ma","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2018.03.004_bib0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2018.02.004","article-title":"Forkhead box O proteins: crucial regulators of cancer EMT","author":"Ma","year":"2018","journal-title":"Semin. Cancer Biol."},{"issue":"20","key":"10.1016\/j.arr.2018.03.004_bib0345","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM198611133152006","article-title":"Huntington's disease. Pathogenesis and management","volume":"315","author":"Martin","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.arr.2018.03.004_bib0350","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/hmg\/ddr148","article-title":"Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter","volume":"20","author":"Martin","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"7182","key":"10.1016\/j.arr.2018.03.004_bib0355","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.arr.2018.03.004_bib0360","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1097-2765(00)00031-9","article-title":"Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1","volume":"6","author":"Monsalve","year":"2000","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.arr.2018.03.004_bib0370","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defines a physiologically important stress response mechanism","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0375","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00018-011-0850-z","article-title":"Transgenic expression and activation of PGC-1alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease","volume":"69","author":"Mudo","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0380","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1089\/ars.2016.6698","article-title":"Heme-oxygenase I and PCG-1alpha regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987","volume":"27","author":"Navarro","year":"2017","journal-title":"Antioxid. Redox Signal."},{"issue":"5608","key":"10.1016\/j.arr.2018.03.004_bib0385","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.1079368","article-title":"Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide","volume":"299","author":"Nisoli","year":"2003","journal-title":"Science"},{"issue":"Pt A","key":"10.1016\/j.arr.2018.03.004_bib0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2014.10.028","article-title":"Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease","volume":"96","author":"Norden","year":"2015","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0395","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0400","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1074\/jbc.M705232200","article-title":"Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress","volume":"283","author":"Okoshi","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0405","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1101\/gad.1624208","article-title":"SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis","volume":"22","author":"Olson","year":"2008","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.arr.2018.03.004_bib0410","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbadis.2010.12.022","article-title":"Mitochondrial defect and PGC-1alpha dysfunction in parkin-associated familial Parkinson's disease","volume":"1812","author":"Pacelli","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0415","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0005-2728(96)00077-1","article-title":"Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications","volume":"1276","author":"Papa","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0420","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/ng1534","article-title":"Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons","volume":"37","author":"Parker","year":"2005","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0425","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1074\/jbc.M508805200","article-title":"Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1","volume":"281","author":"Piantadosi","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5443","key":"10.1016\/j.arr.2018.03.004_bib0430","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1126\/science.286.5443.1368","article-title":"Activation of PPARgamma coactivator-1 through transcription factor docking","volume":"286","author":"Puigserver","year":"1999","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0435","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1097-2765(01)00390-2","article-title":"Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1","volume":"8","author":"Puigserver","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2018.03.004_bib0440","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1385\/CBB:32:1-3:187","article-title":"Peroxisome proliferator-activated receptors, coactivators, and downstream targets","volume":"32","author":"Qi","year":"2000","journal-title":"Cell Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0445","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/archneurol.2008.588","article-title":"PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia","volume":"66","author":"Qin","year":"2009","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0450","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10545-011-9330-8","article-title":"Mitochondrial DNA transcription regulation and nucleoid organization","volume":"34","author":"Rebelo","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.arr.2018.03.004_bib0455","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/B978-0-12-385883-2.00002-3","article-title":"The complex molecular biology of amyotrophic lateral sclerosis (ALS)","volume":"107","author":"Redler","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"22","key":"10.1016\/j.arr.2018.03.004_bib0460","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","article-title":"Amyotrophic lateral sclerosis","volume":"344","author":"Rowland","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"38","key":"10.1016\/j.arr.2018.03.004_bib0465","doi-asserted-by":"crossref","first-page":"26184","DOI":"10.1074\/jbc.M109.038943","article-title":"SUMOylation attenuates the function of PGC-1alpha","volume":"284","author":"Rytinki","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0470","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"34","key":"10.1016\/j.arr.2018.03.004_bib0475","doi-asserted-by":"crossref","first-page":"7805","DOI":"10.1523\/JNEUROSCI.2038-05.2005","article-title":"The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice","volume":"25","author":"Schutz","year":"2005","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.arr.2018.03.004_bib0480","first-page":"1469","article-title":"Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease","volume":"100","author":"Sherer","year":"2007","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0485","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease","volume":"144","author":"Shin","year":"2011","journal-title":"Cell"},{"issue":"29","key":"10.1016\/j.arr.2018.03.004_bib0490","doi-asserted-by":"crossref","first-page":"26597","DOI":"10.1074\/jbc.M301850200","article-title":"Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells","volume":"278","author":"St-Pierre","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0495","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.arr.2018.03.004_bib0500","doi-asserted-by":"crossref","first-page":"498401","DOI":"10.1155\/2015\/498401","article-title":"Electron transport disturbances and neurodegeneration: from Albert Szent-Gyorgyi's concept (Szeged) till novel approaches to boost mitochondrial bioenergetics","volume":"2015","author":"Szalardy","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.arr.2018.03.004_bib0505","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-4-10","article-title":"PGC-1alpha as modifier of onset age in Huntington disease","volume":"4","author":"Taherzadeh-Fard","year":"2009","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0510","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1750-1326-6-32","article-title":"PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease","volume":"6","author":"Taherzadeh-Fard","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"12","key":"10.1016\/j.arr.2018.03.004_bib0515","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.1295005","article-title":"Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation","volume":"19","author":"Teyssier","year":"2005","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.arr.2018.03.004_bib0520","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/NEN.0b013e318275df4b","article-title":"Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS","volume":"71","author":"Thau","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0525","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10571-014-0124-z","article-title":"mRNA expression levels of PGC-1alpha in a transgenic and a toxin model of Huntington's disease","volume":"35","author":"Torok","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0530","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0006-8993(02)03961-6","article-title":"Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain","volume":"961","author":"Tritos","year":"2003","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.arr.2018.03.004_bib0535","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pneurobio.2011.10.004","article-title":"PGC-1alpha at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond","volume":"97","author":"Tsunemi","year":"2012","journal-title":"Prog. Neurobiol."},{"issue":"142","key":"10.1016\/j.arr.2018.03.004_bib0540","doi-asserted-by":"crossref","first-page":"142ra197","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0545","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/febs.13175","article-title":"New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond","volume":"282","author":"Villena","year":"2015","journal-title":"FEBS J."},{"issue":"12A","key":"10.1016\/j.arr.2018.03.004_bib0550","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1101\/gad.7.12a.2431","article-title":"NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators","volume":"7","author":"Virbasius","year":"1993","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.arr.2018.03.004_bib0555","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1101\/gad.7.3.380","article-title":"Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters","volume":"7","author":"Virbasius","year":"1993","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0560","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S1097-2765(03)00391-5","article-title":"Coordination of p300-mediated chromatin remodeling and TRAP\/mediator function through coactivator PGC-1alpha","volume":"12","author":"Wallberg","year":"2003","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.arr.2018.03.004_bib0565","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/STROKEAHA.110.607101","article-title":"Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia","volume":"42","author":"Wang","year":"2011","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0570","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.tiv.2011.02.004","article-title":"Double antioxidant activities of rosiglitazone against high glucose-induced oxidative stress in hepatocyte","volume":"25","author":"Wang","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.arr.2018.03.004_bib0575","doi-asserted-by":"crossref","first-page":"15182","DOI":"10.1038\/ncomms15182","article-title":"Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.arr.2018.03.004_bib0580","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cmet.2006.10.004","article-title":"Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration","volume":"4","author":"Weydt","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2018.03.004_bib0585","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-4-3","article-title":"The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease","volume":"4","author":"Weydt","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2018.03.004_bib0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2377-14-1","article-title":"A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort","volume":"14","author":"Weydt","year":"2014","journal-title":"BMC Neurol."},{"issue":"8","key":"10.1016\/j.arr.2018.03.004_bib0595","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCULATIONAHA.108.812537","article-title":"Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation","volume":"119","author":"Wu","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0600","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-018-0769-1","article-title":"Targeting Gas6\/TAM in cancer cells and tumor microenvironment","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"26","key":"10.1016\/j.arr.2018.03.004_bib0605","doi-asserted-by":"crossref","first-page":"9544","DOI":"10.1523\/JNEUROSCI.1291-11.2011","article-title":"Peroxisome-proliferator-activated receptor gamma coactivator 1 alpha contributes to dysmyelination in experimental models of Huntington's disease","volume":"31","author":"Xiang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2018.03.004_bib0610","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.arr.2017.11.002","article-title":"FOXO1\/3: Potential suppressors of fibrosis","volume":"41","author":"Xin","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0615","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cytogfr.2014.09.002","article-title":"An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders","volume":"26","author":"Yang","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.arr.2018.03.004_bib0620","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbi.2017.03.003","article-title":"Resveratrol regulates microglia M1\/M2 polarization via PGC-1alpha in conditions of neuroinflammatory injury","volume":"64","author":"Yang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2018.03.004_bib0625","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1472-6882-12-82","article-title":"Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1\/PGC-1alpha signaling pathway","volume":"12","author":"Ye","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"issue":"43","key":"10.1016\/j.arr.2018.03.004_bib0630","doi-asserted-by":"crossref","first-page":"74791","DOI":"10.18632\/oncotarget.20422","article-title":"Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT\/GSK-3beta\/HIF-1alpha activation","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.arr.2018.03.004_bib0635","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s10495-017-1378-y","article-title":"Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation","volume":"22","author":"Yu","year":"2017","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.arr.2018.03.004_bib0640","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1750-1326-6-51","article-title":"Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1alpha) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis","volume":"6","author":"Zhao","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"52","key":"10.1016\/j.arr.2018.03.004_bib0645","doi-asserted-by":"crossref","first-page":"52ra73","DOI":"10.1126\/scitranslmed.3001059","article-title":"PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease","volume":"2","author":"Zheng","year":"2010","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.arr.2018.03.004_bib0650","doi-asserted-by":"crossref","first-page":"e35823","DOI":"10.1371\/journal.pone.0035823","article-title":"Diammonium glycyrrhizinate upregulates PGC-1alpha and protects against Abeta1-42-induced neurotoxicity","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS One"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816371830028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816371830028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T21:27:04Z","timestamp":1534973224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156816371830028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":130,"alternative-id":["S156816371830028X"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2018.03.004","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PGC-1\u03b1 sparks the fire of neuroprotection against neurodegenerative disorders","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2018.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}