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(Vienna)"},{"key":"10.1016\/j.arr.2019.101006_bib0460","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.arr.2019.101006_bib0465","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20132451","article-title":"Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer\u2019s disease","volume":"211","author":"Lee","year":"2014","journal-title":"J. Exp. 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