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Med."},{"issue":"3","key":"10.1016\/j.arr.2020.101194_bib0790","doi-asserted-by":"crossref","first-page":"9765","DOI":"10.1007\/s11357-015-9765-1","article-title":"Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat\/high-sucrose feeding at middle age","volume":"37","author":"Hill","year":"2015","journal-title":"Age (Dordr)"},{"issue":"4","key":"10.1016\/j.arr.2020.101194_bib0795","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1210\/en.2006-1157","article-title":"Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system","volume":"148","author":"Hirono","year":"2007","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.arr.2020.101194_bib0800","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10741-010-9183-5","article-title":"Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5","volume":"15","author":"Ho","year":"2010","journal-title":"Heart Fail. 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