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Sci."},{"key":"10.1016\/j.arr.2020.101211_bib0440","doi-asserted-by":"crossref","DOI":"10.1002\/glia.22597","article-title":"Mechanisms of white matter damage in multiple sclerosis","author":"Lassmann","year":"2014","journal-title":"Glia."},{"key":"10.1016\/j.arr.2020.101211_bib0445","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Le Belle","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2020.101211_bib0450","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0310s42","article-title":"Neural stem cell transplantation in mouse brain","author":"Lee","year":"2008","journal-title":"Curr. Protoc. 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Sci."},{"key":"10.1016\/j.arr.2020.101211_bib0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117772","article-title":"Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro","volume":"254","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2020.101211_bib0525","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.neuint.2013.02.025","article-title":"The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF","volume":"62","author":"Ljubisavljevic","year":"2013","journal-title":"Neurochem. 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