{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:43:54Z","timestamp":1792197834552,"version":"4.4.0"},"reference-count":308,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003151","name":"Fonds de recherche du Quebec Nature et technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.arr.2021.101364","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T12:07:41Z","timestamp":1620994061000},"page":"101364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Curcumin nanoformulations to combat aging-related diseases"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-2661","authenticated-orcid":false,"given":"Maryam","family":"Mahjoob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-8695","authenticated-orcid":false,"given":"Ursula","family":"Stochaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2021.101364_bib0005","series-title":"GRAS Notice (GRN) No. 686 for Curcumin","author":"(FDA)","year":"2017"},{"key":"10.1016\/j.arr.2021.101364_bib0010","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10534-016-9959-8","article-title":"Treatment strategies in Alzheimer\u2019s disease: a review with focus on selenium supplementation","volume":"29","author":"Aaseth","year":"2016","journal-title":"BioMetals"},{"key":"10.1016\/j.arr.2021.101364_bib0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jsbmb.2014.02.008","article-title":"Combined administration of curcumin and gallic acid inhibits gallic acid-induced suppression of steroidogenesis, sperm output, antioxidant defenses and inflammatory responsive genes","volume":"143","author":"Abarikwu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0020","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2174\/1871530319666190212170140","article-title":"The neuromodulatory effects of \u03c9-3 fatty acids and nano-curcumin on the COX-2\/ iNOS network in migraines: a clinical trial study from gene expression to clinical symptoms","volume":"19","author":"Abdolahi","year":"2019","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.arr.2021.101364_bib0025","doi-asserted-by":"crossref","first-page":"10852","DOI":"10.1002\/anie.201505641","article-title":"Proteome-wide profiling of targets of cysteine reactive small molecules by using ethynyl benziodoxolone reagents","volume":"54","author":"Abegg","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.arr.2021.101364_bib0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New photosensitizers for photodynamic therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2021.101364_bib0035","first-page":"245","article-title":"Management of burns in the elderly","volume":"29","author":"Abu-Sittah","year":"2016","journal-title":"Ann. Burns Fire Disasters"},{"key":"10.1016\/j.arr.2021.101364_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082201","article-title":"High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis","volume":"12","author":"Aguayo","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2021.101364_bib0045","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00709-013-0516-9","article-title":"A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke","volume":"250","author":"Ahmad","year":"2013","journal-title":"Protoplasma"},{"key":"10.1016\/j.arr.2021.101364_bib0050","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3109\/10717544.2014.941076","article-title":"PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC\/ESI-Q-ToF-MS\/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model","volume":"23","author":"Ahmad","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.arr.2021.101364_bib0055","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s13287-020-01977-0","article-title":"NKX6.1 transcription factor: a crucial regulator of pancreatic \u03b2 cell development, identity, and proliferation","volume":"11","author":"Aigha","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2021.101364_bib0060","doi-asserted-by":"crossref","first-page":"e22243","DOI":"10.1002\/jbt.22243","article-title":"Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule-1, kidney injury molecule-1, and signal transducer and activator of transcription 3 protein expressions","volume":"33","author":"Alharbi","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.arr.2021.101364_bib0065","series-title":"Cardiovascular, Respiratory, and Related Disorders","article-title":"Diabetes: an update on the pandemic and potential solutions","author":"Ali","year":"2017"},{"key":"10.1016\/j.arr.2021.101364_bib0070","doi-asserted-by":"crossref","DOI":"10.3390\/nano10081556","article-title":"Efficacy of polymer-based nanocarriers for co-delivery of curcumin and selected anticancer drugs","volume":"10","author":"Alven","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.arr.2021.101364_bib0075","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1089\/jmf.2017.3930","article-title":"A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study","volume":"20","author":"Amalraj","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.arr.2021.101364_bib0080","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3389\/fimmu.2017.01520","article-title":"Molecular mechanisms modulating the phenotype of macrophages and microglia","volume":"8","author":"Amici","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib0085","doi-asserted-by":"crossref","DOI":"10.3390\/ma13040811","article-title":"Chitosan-TiO(2): a versatile hybrid composite","volume":"13","author":"Anaya-Esparza","year":"2020","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.arr.2021.101364_bib0090","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/gutjnl-2012-304299","article-title":"Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells","volume":"63","author":"Anggakusuma","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.arr.2021.101364_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110452","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2021.101364_bib0100","doi-asserted-by":"crossref","first-page":"e10143","DOI":"10.1002\/btm2.10143","article-title":"Nanoparticles in the clinic: an update","volume":"4","author":"Anselmo","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0105","volume":"Vol. 2020","author":"ANZCTR","year":"2016"},{"key":"10.1016\/j.arr.2021.101364_bib0110","first-page":"43","article-title":"Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study","volume":"53","author":"Appendino","year":"2011","journal-title":"Panminerva Med."},{"key":"10.1016\/j.arr.2021.101364_bib0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ctim.2019.02.014","article-title":"Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo- controlled clinical trial","volume":"43","author":"Asadi","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0120","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/ptr.6571","article-title":"Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial","volume":"34","author":"Asadi","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0125","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/ptr.5905","article-title":"Curcuminoids lower plasma leptin concentrations: a meta-analysis","volume":"31","author":"Atkin","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0130","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1601-0825.2005.01067.x","article-title":"Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells","volume":"11","author":"Atsumi","year":"2005","journal-title":"Oral Dis."},{"key":"10.1016\/j.arr.2021.101364_bib0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40199-015-0115-8","article-title":"Curcumin as a double-edged sword for stem cells: dose, time and cell type-specific responses to curcumin","volume":"23","author":"Attari","year":"2015","journal-title":"Daru J. Pharm. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2017.07.022","article-title":"Pharmacokinetic interactions of curcuminoids with conventional drugs: a review","volume":"209","author":"Bahramsoltani","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0145","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ijbiomac.2017.06.096","article-title":"Nano cellulose dispersed chitosan film with Ag NPs\/Curcumin: an in vivo study on Albino Rats for wound dressing","volume":"104","author":"Bajpai","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.arr.2021.101364_bib0150","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2021.101364_bib0155","first-page":"337","article-title":"Efficacy and safety of Meriva\u00ae, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients","volume":"15","author":"Belcaro","year":"2010","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0160","first-page":"55","article-title":"Product-evaluation registry of Meriva\u00ae, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis","volume":"52","author":"Belcaro","year":"2010","journal-title":"Panminerva Med."},{"key":"10.1016\/j.arr.2021.101364_bib0165","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ptr.5014","article-title":"A controlled study of a lecithinized delivery system of curcumin (Meriva\u00ae) to alleviate the adverse effects of cancer treatment","volume":"28","author":"Belcaro","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0170","first-page":"3959","article-title":"Meriva\u00ae+Glucosamine versus Condroitin+Glucosamine in patients with knee osteoarthritis: an observational study","volume":"18","author":"Belcaro","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0175","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.573032","article-title":"Cellular senescence as the pathogenic hub of diabetes-related wound chronicity","volume":"11","author":"Berlanga-Acosta","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.arr.2021.101364_bib0180","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/biof.1533","article-title":"Benefits of curcumin in brain disorders","volume":"45","author":"Bhat","year":"2019","journal-title":"BioFactors"},{"key":"10.1016\/j.arr.2021.101364_bib0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051239","article-title":"The role of curcumin in the modulation of ageing","volume":"20","author":"Bielak-Zmijewska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0190","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/jphp.12910","article-title":"Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels","volume":"70","author":"Bilia","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0195","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/wound.2019.1021","article-title":"Skin structure-function relationships and the wound healing response to intrinsic aging","volume":"9","author":"Blair","year":"2020","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.arr.2021.101364_bib0200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuint.2016.01.006","article-title":"Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity","volume":"95","author":"Bollimpelli","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2021.101364_bib0210","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.smim.2018.10.011","article-title":"Aging, inflammation and cancer","volume":"40","author":"Bottazzi","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/jnc.14965","article-title":"Synucleinopathies: where we are and where we need to go","volume":"153","author":"Br\u00e1s","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2021.101364_bib0220","doi-asserted-by":"crossref","first-page":"126621","DOI":"10.1016\/j.micres.2020.126621","article-title":"What do we know about the biology of the emerging fungal pathogen of humans Candida auris?","volume":"242","author":"Bravo Ruiz","year":"2020","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0225","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2021.101364_bib0230","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fnagi.2018.00118","article-title":"The physiological roles of amyloid-\u03b2 peptide hint at new ways to treat Alzheimer\u2019s disease","volume":"10","author":"Brothers","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2021.101364_bib0235","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/ijc.24967","article-title":"The dark side of curcumin","volume":"126","author":"Burgos-Mor\u00f3n","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.arr.2021.101364_bib0240","doi-asserted-by":"crossref","first-page":"105526","DOI":"10.1016\/j.phrs.2021.105526","article-title":"The hormetic dose-response mechanism: Nrf2 activation","volume":"167","author":"Calabrese","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s Disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0250","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00020.2018","article-title":"Cellular senescence: aging, cancer, and injury","volume":"99","author":"Calcinotto","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0255","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fphar.2019.00902","article-title":"Mitochondria as potential targets in Alzheimer disease therapy: an update","volume":"10","author":"Cenini","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0260","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijpharm.2018.05.007","article-title":"Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma","volume":"545","author":"Cheng","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.arr.2021.101364_bib0265","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.phrs.2018.08.006","article-title":"Targeting molecular pathways in cancer stem cells by natural bioactive compounds","volume":"135","author":"Cianciosi","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0270","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.3390\/nu11102417","article-title":"Curcumin, hormesis and the nervous system","volume":"11","author":"Concetta Scuto","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2021.101364_bib0275","doi-asserted-by":"crossref","first-page":"34725","DOI":"10.1021\/acsami.9b12319","article-title":"Selenium nanoparticles as an efficient nanomedicine for the therapy of Huntington\u2019s disease","volume":"11","author":"Cong","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.arr.2021.101364_bib0280","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chembiol.2020.03.012","article-title":"Selenium: tracing another essential element of ferroptotic cell death","volume":"27","author":"Conrad","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0285","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/SPC.0000000000000439","article-title":"Multimorbidity in older adults living with and beyond cancer","volume":"13","author":"Corbett","year":"2019","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"10.1016\/j.arr.2021.101364_bib0290","doi-asserted-by":"crossref","DOI":"10.3390\/nu12061678","article-title":"Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: a 12-week, double-blind, placebo-controlled, partial replication study","volume":"12","author":"Cox","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2021.101364_bib0295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/biomedicines5020021","article-title":"Hypoxia and inflammation in cancer, focus on HIF and NF-\u03baB","volume":"5","author":"D\u2019Ignazio","year":"2017","journal-title":"Biomedicines"},{"key":"10.1016\/j.arr.2021.101364_bib0300","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1038\/am.2017.31","article-title":"Nano-formulated curcumin accelerates acute wound healing through Dkk-1-mediated fibroblast mobilization and MCP-1-mediated anti-inflammation","volume":"9","author":"Dai","year":"2017","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.arr.2021.101364_bib0305","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1038\/s41598-018-29393-8","article-title":"Topical curcumin nanocarriers are neuroprotective in eye disease","volume":"8","author":"Davis","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101364_bib0310","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4103\/1673-5374.238608","article-title":"Distinguishing normal brain aging from the development of Alzheimer\u2019s disease: inflammation, insulin signaling and cognition","volume":"13","author":"Denver","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0315","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2021.101364_bib0320","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1158\/1078-0432.CCR-08-0024","article-title":"Phase II trial of curcumin in patients with advanced pancreatic cancer","volume":"14","author":"Dhillon","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.arr.2021.101364_bib0325","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102426","article-title":"Curcumin, gut microbiota, and neuroprotection","volume":"11","author":"Di Meo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2021.101364_bib0330","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12539-011-0090-9","article-title":"Molecular docking studies of curcumin analogs with phospholipase A2","volume":"3","author":"Dileep","year":"2011","journal-title":"Interdiscip. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0335","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jneuroim.2019.01.007","article-title":"Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis","volume":"327","author":"Dolati","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2021.101364_bib0340","doi-asserted-by":"crossref","first-page":"18670","DOI":"10.1073\/pnas.1006586107","article-title":"Early deficits in synaptic mitochondria in an Alzheimer\u2019s disease mouse model","volume":"107","author":"Du","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2021.101364_bib0345","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.2217\/nnm-2017-0106","article-title":"Nanoformulated natural therapeutics for management of streptozotocin-induced diabetes: potential use of curcumin nanoformulation","volume":"12","author":"El-Far","year":"2017","journal-title":"Nanomedicine Lond. (Lond)"},{"key":"10.1016\/j.arr.2021.101364_bib0350","doi-asserted-by":"crossref","first-page":"101151","DOI":"10.1016\/j.arr.2020.101151","article-title":"The ageing kidney: molecular mechanisms and clinical implications","volume":"63","author":"Fang","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0355","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.burns.2018.05.012","article-title":"Burn wounds in the young versus the aged patient display differential immunological responses","volume":"44","author":"Farinas","year":"2018","journal-title":"Burns"},{"key":"10.1016\/j.arr.2021.101364_bib0360","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jamaneurol.2020.4152","article-title":"Burden of neurological disorders across the US from 1990-2017: a global burden of disease study","volume":"78","author":"Feigin","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.arr.2021.101364_bib0365","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2013.01.040","article-title":"Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus","volume":"1504","author":"Foxley","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2021.101364_bib0370","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0375","first-page":"762","article-title":"A novel phospholipid delivery system of curcumin (Meriva\u00ae) preserves muscular mass in healthy aging subjects","volume":"20","author":"Franceschi","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0380","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fmed.2018.00061","article-title":"The continuum of aging and age-related diseases: common mechanisms but different rates","volume":"5","author":"Franceschi","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0385","series-title":"USPTO Patent Full-Text and Image Database, U.S. Patent, ed. (USA)","article-title":"Bioavailable curcuminoid formulations for treating Alzheimer\u2019s disease and other age-related disorders","author":"Frautschy","year":"2015"},{"issue":"Suppl. 4","key":"10.1016\/j.arr.2021.101364_bib0390","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1463-1326.2009.01121.x","article-title":"Pdx1 and other factors that regulate pancreatic beta-cell survival","volume":"11","author":"Fujimoto","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.arr.2021.101364_bib0395","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1507\/endocrj.EJ17-0098","article-title":"Transcriptional regulation of pancreas development and \u03b2-cell function [Review]","volume":"64","author":"Fujitani","year":"2017","journal-title":"Endocr. J."},{"key":"10.1016\/j.arr.2021.101364_bib0400","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/np050327j","article-title":"Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis","volume":"69","author":"Funk","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.arr.2021.101364_bib0405","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/bph.13816","article-title":"Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus","volume":"174","author":"Ganugula","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0410","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2020.03.029","article-title":"Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer\u2019s disease mice","volume":"108","author":"Gao","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2021.101364_bib0415","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/adt.2018.902","article-title":"Coadministration of polypeptide-k and curcumin through solid self-nanoemulsifying drug delivery system for better therapeutic effect against diabetes mellitus: formulation, optimization, biopharmaceutical characterization, and pharmacodynamic assessment","volume":"17","author":"Garg","year":"2019","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.arr.2021.101364_bib0420","doi-asserted-by":"crossref","first-page":"66680","DOI":"10.18632\/oncotarget.19164","article-title":"Nanoformulations of curcumin: an emerging paradigm for improved remedial application","volume":"8","author":"Gera","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.arr.2021.101364_bib0425","doi-asserted-by":"crossref","first-page":"146325","DOI":"10.1016\/j.brainres.2019.146325","article-title":"Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer\u2019s disease induced by \u03b2-amyloid 1-42 peptide in aged female mice","volume":"1721","author":"Giacomeli","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2021.101364_bib0430","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/ars.2008.2256","article-title":"Catalytic antioxidants and neurodegeneration","volume":"11","author":"Golden","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2021.101364_bib0435","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/acs.chemrestox.5b00009","article-title":"Oxidative transformation of demethoxy- and bisdemethoxycurcumin: products, mechanism of formation, and poisoning of human topoisomerase II\u03b1","volume":"28","author":"Gordon","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.arr.2021.101364_bib0440","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s13346-013-0150-2","article-title":"Towards scale-up and regulatory shelf-stability testing of curcumin encapsulated polyester nanoparticles","volume":"3","author":"Grama","year":"2013","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0445","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1212\/WNL.0000000000001912","article-title":"Fruit flies, bile acids, and Parkinson disease: a mitochondrial connection?","volume":"85","author":"Greenamyre","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2021.101364_bib0450","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.14037","article-title":"Brain aging and neurodegeneration: from a mitochondrial point of view","volume":"143","author":"Grimm","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2021.101364_bib0455","doi-asserted-by":"crossref","first-page":"56","DOI":"10.14283\/jpad.2019.50","article-title":"Revisiting the hallmarks of aging to identify markers of biological age","volume":"7","author":"Guerville","year":"2020","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.arr.2021.101364_bib0460","article-title":"Dietary supplementation with palmitoyl-glucosamine co-micronized with curcumin relieves osteoarthritis pain and benefits joint mobility","volume":"10","author":"Gugliandolo","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.arr.2021.101364_bib0465","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.arr.2021.101364_bib0470","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.3389\/fimmu.2018.02160","article-title":"Inflammation, a double-edge sword for cancer and other age-related diseases","volume":"9","author":"Gupta","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib0475","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acs.biomac.9b01724","article-title":"Synthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose-based hydrogels for wound dressing applications","volume":"21","author":"Gupta","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.arr.2021.101364_bib0480","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2147\/JIR.S205390","article-title":"Evaluation of the efficacy and safety of Capsule Longvida(\u00ae) Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study","volume":"12","author":"Gupte","year":"2019","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0485","article-title":"Curcumin pharmacokinetic and pharmacodynamic evidences in streptozotocin-diabetic rats support the antidiabetic activity to Be via metabolite(s)","volume":"2015","author":"Gutierres","year":"2015","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0490","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1073\/pnas.1016217108","article-title":"Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism","volume":"108","author":"Hassaninasab","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2021.101364_bib0495","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: from ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.arr.2021.101364_bib0500","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fonc.2018.00614","article-title":"Bioactivities of EF24, a novel curcumin analog: a review","volume":"8","author":"He","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.arr.2021.101364_bib0505","doi-asserted-by":"crossref","DOI":"10.3390\/foods6100092","article-title":"Curcumin: a review of its effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"10.1016\/j.arr.2021.101364_bib0510","first-page":"92","article-title":"Curcumin: a review of its effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods (Basel, Switzerland)"},{"key":"10.1016\/j.arr.2021.101364_bib0515","series-title":"Stable Solid Lipid Particle Composition For Improved Bioavailability of Lipophilic Compounds for Age-related Diseases. (USA)","author":"Hingorani","year":"2015"},{"key":"10.1016\/j.arr.2021.101364_bib0520","first-page":"107646","article-title":"A new look at brittle diabetes","author":"Hirsch","year":"2020","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.arr.2021.101364_bib0525","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.redox.2016.12.001","article-title":"Happily (n)ever after: aging in the context of oxidative stress, proteostasis loss and cellular senescence","volume":"11","author":"H\u00f6hn","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0530","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.actbio.2020.02.022","article-title":"Antibacterial biohybrid nanofibers for wound dressings","volume":"107","author":"Homaeigohar","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2021.101364_bib0535","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.7150\/jca.30723","article-title":"Aging, cancer and immunity","volume":"10","author":"Hong","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.arr.2021.101364_bib0540","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12035-010-8117-5","article-title":"Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production","volume":"41","author":"Hooff","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2021.101364_bib0545","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/CIRCRESAHA.116.308427","article-title":"Cerebral vascular disease and neurovascular injury in ischemic stroke","volume":"120","author":"Hu","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0550","first-page":"5042","article-title":"Interaction study between antiplatelet agents, anticoagulants, thyroid replacement therapy and a bioavailable formulation of curcumin (Meriva\u00ae)","volume":"22","author":"Hu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0555","doi-asserted-by":"crossref","first-page":"81001","DOI":"10.18632\/oncotarget.20944","article-title":"PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A\u03b2 generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer\u2019s disease mice","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.arr.2021.101364_bib0560","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2017.03.001","article-title":"Cancer acidity: an ultimate frontier of tumor immune escape and a novel target of immunomodulation","volume":"43","author":"Huber","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0565","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071747","article-title":"Senescence and host-pathogen interactions","volume":"9","author":"Humphreys","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2021.101364_bib0570","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jphotobiol.2018.11.008","article-title":"A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid \u03b2 aggregation in Alzheimer\u2019s disease","volume":"190","author":"Huo","year":"2019","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0575","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1515\/revneuro-2018-0084","article-title":"Neurogenesis and brain aging","volume":"30","author":"Isaev","year":"2019","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.arr.2021.101364_bib0580","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2004.01.017","article-title":"Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process","volume":"96","author":"Jaiswal","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.arr.2021.101364_bib0585","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joim.2018.07.001","article-title":"Bioavailable curcumin formulations: a review of pharmacokinetic studies in healthy volunteers","volume":"16","author":"Jamwal","year":"2018","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0590","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1158\/1055-9965.EPI-16-0428","article-title":"Adherence to the WCRF\/AICR dietary recommendations for cancer prevention and risk of cancer in elderly from Europe and the United States: a meta-analysis within the CHANCES project","volume":"26","author":"Jankovic","year":"2017","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.arr.2021.101364_bib0595","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ijmm.2016.2524","article-title":"Determining whether curcumin degradation\/condensation is actually bioactivation (Review)","volume":"37","author":"Jankun","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0600","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fpubh.2017.00335","article-title":"Age-related diseases and clinical and public health implications for the 85 years old and over population","volume":"5","author":"Jaul","year":"2017","journal-title":"Front. Public Health"},{"key":"10.1016\/j.arr.2021.101364_bib0605","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/1756-185X.13688","article-title":"Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: a randomized, double-blind, controlled trial","volume":"22","author":"Javadi","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.arr.2021.101364_bib0610","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s00125-020-05161-0","article-title":"Transcription factors that shape the mammalian pancreas","volume":"63","author":"Jennings","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2021.101364_bib0615","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.ebiom.2015.07.040","article-title":"Pathophysiologic response to Burns in the elderly","volume":"2","author":"Jeschke","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2021.101364_bib0620","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.burns.2015.12.008","article-title":"Threshold age and burn size associated with poor outcomes in the elderly after burn injury","volume":"42","author":"Jeschke","year":"2016","journal-title":"Burns"},{"key":"10.1016\/j.arr.2021.101364_bib0625","doi-asserted-by":"crossref","first-page":"e0152371","DOI":"10.1371\/journal.pone.0152371","article-title":"Quercetin protects against okadaic acid-induced injury via MAPK and PI3K\/Akt\/GSK3\u03b2 signaling pathways in HT22 hippocampal neurons","volume":"11","author":"Jiang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2021.101364_bib0630","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2174\/1389203717666160627081207","article-title":"Bridge proteins\" link inflammation and metabolic diseases: potential targets for therapeutics","volume":"18","author":"Jiang","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0635","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.arr.2021.101364_bib0640","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1080\/03639045.2018.1492607","article-title":"Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study","volume":"44","author":"Kakkar","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.arr.2021.101364_bib0645","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00280-011-1673-1","article-title":"Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers","volume":"69","author":"Kanai","year":"2012","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0650","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bcp.2005.01.014","article-title":"Curcumin-induced histone hypoacetylation: the role of reactive oxygen species","volume":"69","author":"Kang","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0655","doi-asserted-by":"crossref","first-page":"102104","DOI":"10.1016\/j.nano.2019.102104","article-title":"Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis","volume":"23","author":"Kang","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0660","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010212","article-title":"Curcumin metabolite tetrahydrocurcumin in the treatment of eye diseases","volume":"22","author":"Kao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0665","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fphar.2020.00487","article-title":"Nanocurcumin: a promising candidate for therapeutic applications","volume":"11","author":"Karthikeyan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0670","doi-asserted-by":"crossref","first-page":"7","DOI":"10.18869\/acadpub.cmm.2.1.7","article-title":"An investigation of the inhibitory effects of dendrosomal nanocurcumin on Candida albicans and systemic candidiasis in BALB\/c mice","volume":"2","author":"Katiraee","year":"2016","journal-title":"Curr. Med. Mycol."},{"key":"10.1016\/j.arr.2021.101364_bib0675","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1039\/c9pp00375d","article-title":"Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells","volume":"19","author":"Kazantzis","year":"2020","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0680","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0921-8777(01)00066-0","article-title":"Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA","volume":"485","author":"Kelly","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0685","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2174\/1567201814666171019104002","article-title":"Polymeric nano-encapsulation of curcumin enhances its anti-cancer activity in breast (MDA-MB231) and Lung (A549) cancer cells through reduction in expression of HIF-1\u03b1 and nuclear p65 (Rel a)","volume":"15","author":"Khan","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.arr.2021.101364_bib0690","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.jafc.6b04815","article-title":"Physical and chemical stability of curcumin in aqueous solutions and emulsions: impact of pH, temperature, and molecular environment","volume":"65","author":"Kharat","year":"2017","journal-title":"J. Agric. Food Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.arr.2021.101364_bib0695","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1111\/j.1753-4887.2010.00343.x","article-title":"Global aging and the brain","volume":"68","author":"Kirkwood","year":"2010","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0700","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/IJNRD.S103784","article-title":"Rodent models of diabetic nephropathy: their utility and limitations","volume":"9","author":"Kitada","year":"2016","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"10.1016\/j.arr.2021.101364_bib0705","doi-asserted-by":"crossref","first-page":"458592","DOI":"10.1155\/2014\/458592","article-title":"Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects","volume":"2014","author":"Klickovic","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.arr.2021.101364_bib0710","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mib.2015.11.003","article-title":"Infection in an aging population","volume":"29","author":"Kline","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.arr.2021.101364_bib0715","first-page":"220","article-title":"2019 American College of Rheumatology\/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"."},{"key":"10.1016\/j.arr.2021.101364_bib0720","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24162930","article-title":"Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects","volume":"24","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib0725","doi-asserted-by":"crossref","first-page":"e13270","DOI":"10.1111\/acel.13270","article-title":"On the evolution of cellular senescence","author":"Kowald","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2021.101364_bib0730","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nano.2014.09.004","article-title":"Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent","volume":"11","author":"Krausz","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.arr.2021.101364_bib0735","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090821","article-title":"Silver nanomaterials for wound dressing applications","volume":"12","author":"Krishnan","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.arr.2021.101364_bib0740","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1517\/14728222.2012.710603","article-title":"Curcumin: a potential candidate for matrix metalloproteinase inhibitors","volume":"16","author":"Kumar","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.arr.2021.101364_bib0745","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/acschemneuro.6b00207","article-title":"Delivery of dual drug loaded lipid based nanoparticles across the blood-brain barrier impart enhanced neuroprotection in a rotenone induced mouse model of Parkinson\u2019s disease","volume":"7","author":"Kundu","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2021.101364_bib0750","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2019.02.036","article-title":"pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy","volume":"18","author":"Kundu","year":"2019","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.arr.2021.101364_bib0755","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1042\/CS20160935","article-title":"Curcumin mediates anticancer effects by modulating multiple cell signaling pathways","volume":"131","author":"Kunnumakkara","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0760","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12902-019-0463-3","article-title":"Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe","volume":"20","author":"Kyrou","year":"2020","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.arr.2021.101364_bib0765","doi-asserted-by":"crossref","DOI":"10.3390\/biom10060831","article-title":"The cancer chemopreventive and therapeutic potential of tetrahydrocurcumin","volume":"10","author":"Lai","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2021.101364_bib0770","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1038\/s41598-018-20179-6","article-title":"Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth","volume":"8","author":"Larasati","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101364_bib0775","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020361","article-title":"The immunopathogenesis of Alzheimer\u2019s disease is related to the composition of gut microbiota","volume":"13","author":"Leblhuber","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2021.101364_bib0780","first-page":"444","article-title":"Temporary kidney dysfunction: supplementation with Meriva\u00ae in initial, transient kidney micro-macro albuminuria","volume":"61","author":"Ledda","year":"2019","journal-title":"Panminerva Med."},{"key":"10.1016\/j.arr.2021.101364_bib0785","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1570159X11311040002","article-title":"Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century","volume":"11","author":"Lee","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0790","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25204610","article-title":"An EGF- and curcumin-co-encapsulated nanostructured lipid carrier accelerates chronic-wound healing in diabetic rats","volume":"25","author":"Lee","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib0795","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.vph.2012.09.002","article-title":"Phytochemicals and their impact on adipose tissue inflammation and diabetes","volume":"58","author":"Leiherer","year":"2013","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0800","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2021.101364_bib0805","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2174\/0929867024606704","article-title":"Thiol-dependent enzymes and their inhibitors: a review","volume":"9","author":"Leung-Toung","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.arr.2021.101364_bib0810","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.addr.2016.09.004","article-title":"The effects of dietary and herbal phytochemicals on drug transporters","volume":"116","author":"Li","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0815","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mad.2019.05.001","article-title":"Emerging senolytic agents derived from natural products","volume":"181","author":"Li","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2021.101364_bib0820","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176305","article-title":"Interactions of zinc oxide nanostructures with mammalian cells: cytotoxicity and photocatalytic toxicity","volume":"21","author":"Liao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0825","series-title":"Encyclopedia of Gerontology and Population Aging","first-page":"1","article-title":"Aging definition","author":"Libertini","year":"2019"},{"key":"10.1016\/j.arr.2021.101364_bib0830","article-title":"Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson\u2019s disease model","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.arr.2021.101364_bib0835","first-page":"e2001167","article-title":"Construction of enzyme nanoreactors to enable tumor microenvironment modulation and enhanced cancer treatment","author":"Liu","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.arr.2021.101364_bib0840","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/BOR.0b013e3283494005","article-title":"Aging and osteoarthritis","volume":"23","author":"Loeser","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.arr.2021.101364_bib0845","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1021\/np070332i","article-title":"Curcumin induces high levels of topoisomerase I\u2212 and II\u2212DNA complexes in K562 leukemia cells","volume":"70","author":"L\u00f3pez-L\u00e1zaro","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.arr.2021.101364_bib0850","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2021.101364_bib0855","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2353\/ajpath.2008.080434","article-title":"Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer\u2019s disease","volume":"173","author":"Louneva","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.arr.2021.101364_bib0860","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/acs.chemrestox.7b00326","article-title":"Thiol reactivity of curcumin and its oxidation products","volume":"31","author":"Luis","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.arr.2021.101364_bib0865","first-page":"811","article-title":"Evaluation of liposomal curcumin cytochrome p450 metabolism","volume":"30","author":"Mach","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.arr.2021.101364_bib0870","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.01.004","article-title":"Diabetic microangiopathy: pathogenetic insights and novel therapeutic approaches","volume":"90","author":"Madonna","year":"2017","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101678","article-title":"Interrelation between ROS and Ca(2+) in aging and age-related diseases","volume":"36","author":"Madreiter-Sokolowski","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0880","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12868-018-0406-3","article-title":"Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"19","author":"Maiti","year":"2018","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.arr.2021.101364_bib0885","first-page":"255","article-title":"Pathogenesis of wound healing disorders in the elderly","volume":"15","author":"Makrantonaki","year":"2017","journal-title":"J. Dermatol. Ges."},{"key":"10.1016\/j.arr.2021.101364_bib0890","doi-asserted-by":"crossref","first-page":"396708","DOI":"10.1155\/2014\/396708","article-title":"Structure-function elucidation of antioxidative and prooxidative activities of the polyphenolic compound curcumin","volume":"2014","author":"Malik","year":"2014","journal-title":"Chinese J. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0895","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2217\/cpr.14.46","article-title":"Chronic kidney disease in the elderly: evaluation and management","volume":"11","author":"Mallappallil","year":"2014","journal-title":"Clin. Pract. (Lond)"},{"key":"10.1016\/j.arr.2021.101364_bib0900","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1186\/s12885-020-07256-8","article-title":"Clinical effects of curcumin in enhancing cancer therapy: a systematic review","volume":"20","author":"Mansouri","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.arr.2021.101364_bib0905","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/mnfr.201200791","article-title":"Targeted delivery of curcumin for treating type 2 diabetes","volume":"57","author":"Maradana","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.arr.2021.101364_bib0910","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/med.21702","article-title":"Emerging use of senolytics and senomorphics against aging and chronic diseases","volume":"40","author":"Martel","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib0915","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijbiomac.2019.12.077","article-title":"Nonwoven fabric supported, chitosan membrane anchored with curcumin\/TiO2 complex: scaffolds for MRSA infected wound skin reconstruction","volume":"144","author":"Marulasiddeshwara","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2021.101364_bib0920","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmgm.2017.10.022","article-title":"Metal chelating ability and antioxidant properties of curcumin-metal complexes \u2013 a DFT approach","volume":"79","author":"Mary","year":"2018","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.arr.2021.101364_bib0925","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40199-020-00331-2","article-title":"HSA-curcumin nanoparticles: a promising substitution for Curcumin as a Cancer chemoprevention and therapy","volume":"28","author":"Matloubi","year":"2020","journal-title":"Daru"},{"key":"10.1016\/j.arr.2021.101364_bib0930","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jalz.2018.06.3063","article-title":"Racial and ethnic estimates of Alzheimer\u2019s disease and related dementias in the United States (2015\u20132060) in adults aged \u226565 years","volume":"15","author":"Matthews","year":"2019","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"10.1016\/j.arr.2021.101364_bib0935","series-title":"Turmeric, Adverse Effects","author":"Medscape","year":"2021"},{"key":"10.1016\/j.arr.2021.101364_bib0940","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2013.00137","article-title":"Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response","volume":"3","author":"Milano","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.arr.2021.101364_bib0945","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00002512-200421020-00002","article-title":"Role of hydrogen peroxide in the aetiology of Alzheimer\u2019s disease","volume":"21","author":"Milton","year":"2004","journal-title":"Drugs Aging"},{"key":"10.1016\/j.arr.2021.101364_bib0950","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041216","article-title":"Common musculoskeletal disorders in the elderly: the star triad","volume":"9","author":"Minetto","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.arr.2021.101364_bib0955","doi-asserted-by":"crossref","first-page":"101639","DOI":"10.1016\/j.pdpdt.2019.101639","article-title":"Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles","volume":"29","author":"Mirzahosseinipour","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.arr.2021.101364_bib0960","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/ijms21051661","article-title":"Cell-type specific metabolic response of cancer cells to curcumin","volume":"21","author":"Mojze\u0161","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0965","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217984","article-title":"Treating senescence like cancer: novel perspectives in senotherapy of chronic diseases","volume":"21","author":"Mongelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib0970","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.clim.2019.02.002","article-title":"Immune aging in diabetes and its implications in wound healing","volume":"200","author":"Moura","year":"2019","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib0975","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25184102","article-title":"Role of photoactive phytocompounds in photodynamic therapy of cancer","volume":"25","author":"Muniyandi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib0980","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1242\/jeb.132142","article-title":"A radical shift in perspective: mitochondria as regulators of reactive oxygen species","volume":"220","author":"Munro","year":"2017","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib0985","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/mnfr.201200131","article-title":"Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial","volume":"57","author":"Na","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.arr.2021.101364_bib0990","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/NHA-170030","article-title":"Gut microbiome and aging: physiological and mechanistic insights","volume":"4","author":"Nagpal","year":"2018","journal-title":"Nutr. Healthy Aging"},{"key":"10.1016\/j.arr.2021.101364_bib0995","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.3390\/molecules24224067","article-title":"Curcumin derivatives verify the essentiality of ROS upregulation in tumor suppression","volume":"24","author":"Nakamae","year":"2019","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.arr.2021.101364_bib1000","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.biomaterials.2013.12.090","article-title":"Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment","volume":"35","author":"Naksuriya","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2021.101364_bib1005","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.2147\/IJN.S82788","article-title":"Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation","volume":"10","author":"Naz","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.arr.2021.101364_bib1010","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.arr.2021.101364_bib1015","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.xphs.2018.10.042","article-title":"Dual-targeting nanoparticles: codelivery of curcumin and 5-fluorouracil for synergistic treatment of hepatocarcinoma","volume":"108","author":"Ni","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib1020","series-title":"Health Information","article-title":"Turmeric","author":"NIH","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1025","volume":"Vol. 2020","author":"NIH","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1030","volume":"Vol. 2020","author":"NIH","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1035","volume":"Vol. 2020","author":"NIH","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1040","doi-asserted-by":"crossref","first-page":"110339","DOI":"10.1016\/j.colsurfb.2019.06.068","article-title":"Enhanced wound healing by PVA\/chitosan\/curcumin patches: in vitro and in vivo study","volume":"182","author":"Niranjan","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.arr.2021.101364_bib1045","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms5010009","article-title":"Microbial biofilms and chronic wounds","volume":"5","author":"Omar","year":"2017","journal-title":"Microorganisms"},{"key":"10.1016\/j.arr.2021.101364_bib1050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.msec.2017.03.292","article-title":"Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model","volume":"78","author":"Oruno\u011flu","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.arr.2021.101364_bib1055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-60761-756-3_18","article-title":"Measurement of oxidized\/reduced glutathione ratio","volume":"648","author":"Owen","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib1060","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1002\/ptr.6724","article-title":"Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-\u03baB\/VEGF\/MMP-9 pathway","volume":"34","author":"Pan","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1065","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s13346-018-0570-0","article-title":"Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease","volume":"8","author":"Parikh","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phrs.2018.09.012","article-title":"Therapeutic potential of curcumin in diabetic complications","volume":"136","author":"Parsamanesh","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1075","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.phrs.2018.03.013","article-title":"Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: results of a prospective phase II trial","volume":"132","author":"Pastorelli","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1080","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3892\/etm.2015.2749","article-title":"Biological and therapeutic activities, and anticancer properties of curcumin","volume":"10","author":"Perrone","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.arr.2021.101364_bib1085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031055","article-title":"Mutual two-way interactions of curcumin and gut microbiota","volume":"21","author":"Pluta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib1090","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.192.Supp.132.21","article-title":"NanoCurcumin inhibits TNF-\u03b1 in Mycobacterium tuberculosis-infected macrophages (MPF3P.821)","volume":"192","author":"Pokkali","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib1095","doi-asserted-by":"crossref","first-page":"16962","DOI":"10.1039\/C8NR04073G","article-title":"Treatment of neurodegenerative disorders through the blood\u2013brain barrier using nanocarriers","volume":"10","author":"Poovaiah","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.arr.2021.101364_bib1100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5138\/09750185.2271","article-title":"Nano-curcumin: a potent enhancer of body antioxidant system in diabetic mice","volume":"10","author":"Potphode","year":"2018","journal-title":"Int. J. Phytomedicine"},{"key":"10.1016\/j.arr.2021.101364_bib1105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.addr.2018.04.011","article-title":"Scarless wound healing: from development to senescence","volume":"146","author":"Pratsinis","year":"2019","journal-title":"Adv. Drug Del. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib1110","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib1115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0891-5849(03)00325-3","article-title":"Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin","volume":"35","author":"Priyadarsini","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib1120","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1080\/10717544.2017.1410256","article-title":"Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy","volume":"24","author":"Qi","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.arr.2021.101364_bib1125","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41420-019-0234-y","article-title":"Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation","volume":"5","author":"Rainey","year":"2019","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.arr.2021.101364_bib1130","doi-asserted-by":"crossref","first-page":"3656419","DOI":"10.1155\/2020\/3656419","article-title":"Curcumin, a multifaceted hormetic agent, mediates an intricate crosstalk between mitochondrial turnover, autophagy, and apoptosis","volume":"2020","author":"Rainey","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2021.101364_bib1135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12935-015-0241-x","article-title":"Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy","volume":"15","author":"Ramasamy","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.arr.2021.101364_bib1140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000481261","article-title":"Modulation of the proteasome pathway by nano-curcumin and curcumin in retinal pigment epithelial cells","volume":"59","author":"Ramos de Carvalho","year":"2018","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.arr.2021.101364_bib1145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.mad.2008.12.007","article-title":"Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells","volume":"130","author":"Rashidi","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2021.101364_bib1150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2010-101374","article-title":"Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc\u2122) in the neuronal cell culture and animal model: implications for Alzheimer\u2019s disease","volume":"23","author":"Ray","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2021.101364_bib1155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fendo.2018.00258","article-title":"Aging hallmarks: the benefits of physical exercise","volume":"9","author":"Rebelo-Marques","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.arr.2021.101364_bib1160","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1007\/s00125-020-05211-7","article-title":"The clinical consequences of heterogeneity within and between different diabetes types","volume":"63","author":"Redondo","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2021.101364_bib1165","doi-asserted-by":"crossref","first-page":"e1007108","DOI":"10.1371\/journal.pgen.1007108","article-title":"Aging and the rise of somatic cancer-associated mutations in normal tissues","volume":"14","author":"Risques","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.arr.2021.101364_bib1170","doi-asserted-by":"crossref","first-page":"9372182","DOI":"10.1155\/2019\/9372182","article-title":"Activators and inhibitors of NRF2: a review of their potential for clinical development","volume":"2019","author":"Robledinos-Ant\u00f3n","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2021.101364_bib1175","doi-asserted-by":"crossref","first-page":"896","DOI":"10.18632\/aging.100384","article-title":"Epidermal growth factor and aging: a signaling molecule reveals a new eye opening function","volume":"3","author":"Rongo","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.arr.2021.101364_bib1180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13054-015-0961-2","article-title":"Burn wound healing and treatment: review and advancements","volume":"19","author":"Rowan","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.arr.2021.101364_bib1185","doi-asserted-by":"crossref","first-page":"113719","DOI":"10.1016\/j.bcp.2019.113719","article-title":"Mechanisms of aging and potential role of selected polyphenols in extending healthspan","volume":"173","author":"Russo","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2021.101364_bib1190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25204839","article-title":"The multi-faceted effect of curcumin in glioblastoma from rescuing cell clearance to autophagy-independent effects","volume":"25","author":"Ryskalin","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib1195","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1039\/D0TB00772B","article-title":"Facile design of autogenous stimuli-responsive chitosan\/hyaluronic acid nanoparticles for efficient small molecules to protein delivery","volume":"8","author":"Sabourian","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.arr.2021.101364_bib1200","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tibs.2020.09.004","article-title":"How lysosomes sense, integrate, and cope with stress","volume":"46","author":"Saftig","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib1205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar148","article-title":"Articular cartilage and changes in Arthritis: cell biology of osteoarthritis","volume":"3","author":"Sandell","year":"2001","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.arr.2021.101364_bib1210","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.freeradbiomed.2007.05.009","article-title":"Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)","volume":"43","author":"Sandur","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib1215","doi-asserted-by":"crossref","first-page":"110356","DOI":"10.1016\/j.msec.2019.110356","article-title":"Redox responsive xylan-SS-curcumin prodrug nanoparticles for dual drug delivery in cancer therapy","volume":"107","author":"Sauraj Vinay","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.arr.2021.101364_bib1220","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092499","article-title":"Interaction between gut microbiota and curcumin: a new key of understanding for the health effects of curcumin","volume":"12","author":"Scazzocchio","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2021.101364_bib1225","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1582-4934.2008.00339.x","article-title":"Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation","volume":"13","author":"Scharstuhl","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.arr.2021.101364_bib1230","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1021\/acs.jafc.5b00244","article-title":"Degradation of curcumin: from mechanism to biological implications","volume":"63","author":"Schneider","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.arr.2021.101364_bib1235","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1038\/s41598-017-15792-w","article-title":"Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins","volume":"7","author":"Seisenbaeva","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101364_bib1240","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/ptr.6885","article-title":"Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreatic \u03b2-cells and restoring their dysfunction","volume":"35","author":"Semwal","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1245","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phrs.2017.11.030","article-title":"Phytochemicals as inhibitors of NF-\u03baB for treatment of Alzheimer\u2019s disease","volume":"129","author":"Seo","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1250","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3390\/ijms18051068","article-title":"The role of phytochemicals in the inflammatory phase of wound healing","volume":"18","author":"Shah","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2021.101364_bib1255","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2174\/1381612826666200928160357","article-title":"Medicinal plants and bioactive compounds for diabetes management: important advances for drug discovery","volume":"27","author":"Shanmugam","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2021.101364_bib1260","doi-asserted-by":"crossref","first-page":"101141","DOI":"10.1016\/j.arr.2020.101141","article-title":"Nutraceuticals-based immunotherapeutic concepts and opportunities for the mitigation of cellular senescence and aging: a narrative review","author":"Sharma","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2021.101364_bib1265","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1158\/1078-0432.CCR-09-1749","article-title":"Contribution of degradation products to the anticancer activity of curcumin","volume":"15","author":"Shen","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.arr.2021.101364_bib1270","first-page":"75","article-title":"Clinical application of \u201ccurcumin\u201d, a multi-functional substance","volume":"9","author":"Shimatsu","year":"2012","journal-title":"Anti-Aging Med"},{"key":"10.1016\/j.arr.2021.101364_bib1275","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2174\/156720509790147115","article-title":"Optimized turmeric extracts have potent anti-amyloidogenic effects","volume":"6","author":"Shytle","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2021.101364_bib1280","doi-asserted-by":"crossref","first-page":"119725","DOI":"10.1016\/j.ijpharm.2020.119725","article-title":"AmyloLipid Nanovesicles: a self-assembled lipid-modified starch hybrid system constructed for direct nose-to-brain delivery of curcumin","volume":"588","author":"Sintov","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.arr.2021.101364_bib1285","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17425247.2020.1702644","article-title":"A short review on chemical properties, stability and nano-technological advances for curcumin delivery","volume":"17","author":"Slika","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.arr.2021.101364_bib1290","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1295","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12640-011-9249-8","article-title":"Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain","volume":"20","author":"Sood","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1300","doi-asserted-by":"crossref","first-page":"555409","DOI":"10.3389\/fcell.2020.555409","article-title":"Natural compounds and autophagy: allies against neurodegeneration","volume":"8","author":"Stacchiotti","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib1305","first-page":"11","article-title":"Meriva\u00ae, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy","volume":"54","author":"Steigerwalt","year":"2012","journal-title":"Panminerva Med."},{"key":"10.1016\/j.arr.2021.101364_bib1310","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5414\/CP202076","article-title":"Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans","volume":"53","author":"Storka","year":"2015","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.arr.2021.101364_bib1315","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3177\/jnsv.61.37","article-title":"Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study","volume":"61","author":"Sunagawa","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.arr.2021.101364_bib1320","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1158\/1535-7163.1101.3.9","article-title":"Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2","volume":"3","author":"Syng-ai","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.arr.2021.101364_bib1325","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1073\/pnas.1320953111","article-title":"Nkx6.1 regulates islet \u03b2-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors","volume":"111","author":"Tessem","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2021.101364_bib1330","first-page":"449","article-title":"NF-\u03baB in aging and disease","volume":"2","author":"Tilstra","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2021.101364_bib1335","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4103\/0970-0358.101319","article-title":"Burn wound: How it differs from other wounds?","volume":"45","author":"Tiwari","year":"2012","journal-title":"Indian J. Plast. Surg."},{"key":"10.1016\/j.arr.2021.101364_bib1340","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41575-020-0339-z","article-title":"Parkinson disease and the gut: new insights into pathogenesis and clinical relevance","volume":"17","author":"Travagli","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.arr.2021.101364_bib1345","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225240","article-title":"Implementing curcumin in translational oncology research","volume":"25","author":"Tro\u0161elj","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib1350","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.redox.2013.09.003","article-title":"Renoprotective effect of the antioxidant curcumin: recent findings","volume":"1","author":"Trujillo","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2021.101364_bib1355","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fnins.2020.00170","article-title":"Evaluation of phytosomal curcumin as an anti-inflammatory agent for chronic glial activation in the GFAP-IL6 mouse model","volume":"14","author":"Ullah","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2021.101364_bib1360","doi-asserted-by":"crossref","first-page":"e00972","DOI":"10.1128\/mSphere.00972-19","article-title":"Candida auris biofilm colonization on skin niche conditions","volume":"5","author":"Uppuluri","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.arr.2021.101364_bib1365","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00447","article-title":"Nanodelivery of natural antioxidants: an anti-aging perspective","volume":"7","author":"Vaiserman","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2021.101364_bib1370","doi-asserted-by":"crossref","first-page":"110515","DOI":"10.1016\/j.colsurfb.2019.110515","article-title":"Methotrexate and curcumin co-encapsulated PLGA nanoparticles as a potential breast cancer therapeutic system: in vitro and in vivo evaluation","volume":"184","author":"Vakilinezhad","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.arr.2021.101364_bib1375","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.arr.2021.101364_bib1380","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijbiomac.2017.02.002","article-title":"Investigation on Curcumin nanocomposite for wound dressing","volume":"98","author":"Venkatasubbu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2021.101364_bib1385","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1089\/ars.2012.4573","article-title":"Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance","volume":"18","author":"Vinod","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2021.101364_bib1390","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2013.29","article-title":"Oxidative stress and the ageing endocrine system","volume":"9","author":"Vitale","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2021.101364_bib1395","doi-asserted-by":"crossref","first-page":"1930261","DOI":"10.1155\/2017\/1930261","article-title":"Oxidative stress in pancreatic beta cell regeneration","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2021.101364_bib1400","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.7150\/jca.45176","article-title":"Curcumin induces G2\/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.arr.2021.101364_bib1405","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01941","article-title":"Redefining the role of langerhans cells as immune regulators within the skin","volume":"8","author":"West","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2021.101364_bib1410","doi-asserted-by":"crossref","first-page":"104280","DOI":"10.1016\/j.phrs.2019.104280","article-title":"Oral turmeric\/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials","volume":"146","author":"White","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1415","article-title":"Ageing and health","volume":"Vol. 2020","author":"WHO","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1420","series-title":"World Cancer Report: Cancer Research for Cancer Prevention","author":"WHO","year":"2020"},{"key":"10.1016\/j.arr.2021.101364_bib1425","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00773","article-title":"Senescence in wound repair: emerging strategies to target chronic healing wounds","volume":"8","author":"Wilkinson","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2021.101364_bib1430","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijpharm.2018.08.007","article-title":"NLC versus nanoemulsions: effect on physiological skin parameters during regular in vivo application and impact on drug penetration","volume":"549","author":"Wolf","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.arr.2021.101364_bib1435","series-title":"Curr. Protoc. Pharmacol. Chapter 5, Unit 5.47","article-title":"Streptozotocin-induced diabetic models in mice and rats","author":"Wu","year":"2008"},{"key":"10.1016\/j.arr.2021.101364_bib1440","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/C3FO60370A","article-title":"Chemopreventative effects of tetrahydrocurcumin on human diseases","volume":"5","author":"Wu","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2021.101364_bib1445","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082134","article-title":"Senescence and cancer: a review of clinical implications of senescence and senotherapies","volume":"12","author":"Wyld","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2021.101364_bib1450","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.schres.2017.09.046","article-title":"The effects of curcumin on brain-derived neurotrophic factor and cognition in schizophrenia: a randomized controlled study","volume":"195","author":"Wynn","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.arr.2021.101364_bib1455","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2021.101364_bib1460","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ijbiomac.2019.04.201","article-title":"Mesenchymal stem cells-curcumin loaded chitosan nanoparticles hybrid vectors for tumor-tropic therapy","volume":"134","author":"Xu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2021.101364_bib1465","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1208\/s12248-015-9811-z","article-title":"Therapeutic applications of curcumin nanoformulations","volume":"17","author":"Yallapu","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.arr.2021.101364_bib1470","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1039\/C5NR07918G","article-title":"Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection","volume":"8","author":"Yang","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.arr.2021.101364_bib1475","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s11671-018-2759-z","article-title":"Curcumin-loaded chitosan-bovine serum albumin nanoparticles potentially enhanced A\u03b2 42 phagocytosis and modulated macrophage polarization in Alzheimer\u2019s disease","volume":"13","author":"Yang","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.arr.2021.101364_bib1480","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10787-019-00613-5","article-title":"Microglial polarization: novel therapeutic mechanism against Alzheimer\u2019s disease","volume":"28","author":"Yao","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.arr.2021.101364_bib1485","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.2147\/IJN.S208332","article-title":"Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders","volume":"14","author":"Yavarpour-Bali","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.arr.2021.101364_bib1490","doi-asserted-by":"crossref","first-page":"e111559","DOI":"10.1371\/journal.pone.0111559","article-title":"Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NF\u03baB signaling and macrophage migration","volume":"9","author":"Young","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2021.101364_bib1495","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1038\/srep20051","article-title":"Curcumin nanoformulation for cervical cancer treatment","volume":"6","author":"Zaman","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101364_bib1500","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1021\/am501341u","article-title":"Epigallocatechin-3-gallate (EGCG)-stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-\u03b2 aggregation and cytotoxicity","volume":"6","author":"Zhang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.arr.2021.101364_bib1505","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.bbagen.2014.08.001","article-title":"Selenoproteins and selenium status in bone physiology and pathology","volume":"1840","author":"Zhang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2021.101364_bib1510","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.7150\/thno.23734","article-title":"Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson\u2019s disease therapy","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2021.101364_bib1515","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.3390\/molecules25122791","article-title":"Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability","volume":"25","author":"Zheng","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2021.101364_bib1520","first-page":"4931","article-title":"The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats","volume":"9","author":"Zheng","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.arr.2021.101364_bib1525","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202000171","article-title":"Antibacterial mechanism of curcumin: a review","author":"Zheng","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.arr.2021.101364_bib1530","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111921","article-title":"Nanoceria-curcumin conjugate: synthesis and selective cytotoxicity against cancer cells under oxidative stress conditions","volume":"209","author":"Zholobak","year":"2020","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.arr.2021.101364_bib1535","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1039\/C6FO01770C","article-title":"Potential roles of chemical degradation in the biological activities of curcumin","volume":"8","author":"Zhu","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2021.101364_bib1540","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.3390\/ijms20184472","article-title":"Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments","volume":"20","author":"Zuo","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163721001112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163721001112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:50:05Z","timestamp":1761591005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163721001112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":308,"alternative-id":["S1568163721001112"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2021.101364","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin nanoformulations to combat aging-related diseases","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2021.101364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101364"}}