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Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0167-8760(03)00020-5","article-title":"Psychophysical evaluation of responses to pleasant and mal-odour stimulation in human subjects; adaptation, dose response and gender differences","volume":"48","author":"Jacob","year":"2003","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.arr.2021.101416_bib0380","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1001\/jamaneurol.2017.0985","article-title":"Conversion to Parkinson disease in the PARS hyposmic and dopamine transporter-deficit prodromal cohort","volume":"74","author":"Jennings","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2021.101416_bib0385","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.14336\/AD.2018.1116","article-title":"Entorhinal cortex atrophy in early, drug-naive Parkinson\u2019s disease with mild cognitive impairment","volume":"10","author":"Jia","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2021.101416_bib0390","doi-asserted-by":"crossref","first-page":"9242","DOI":"10.1038\/s41598-020-66201-8","article-title":"Deficits in olfactory sensitivity in a mouse model of Parkinson\u2019s disease revealed by plethysmography of odor-evoked sniffing","volume":"10","author":"Johnson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101416_bib0395","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/lary.27399","article-title":"Olfactory function in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis: Olfactory Function Deficit in MCI and AD","volume":"129","author":"Jung","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.arr.2021.101416_bib0400","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/lary.27399","article-title":"Olfactory function in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis","volume":"129","author":"Jung","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.arr.2021.101416_bib0405","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1152\/jn.00812.2005","article-title":"Olfactory cortical adaptation facilitates detection of odors against background","volume":"95","author":"Kadohisa","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.arr.2021.101416_bib0410","doi-asserted-by":"crossref","first-page":"45851","DOI":"10.1038\/srep45851","article-title":"Differences in peripheral sensory input to the olfactory bulb between male and female mice","volume":"7","author":"Kass","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2021.101416_bib0415","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4067\/S0717-95022011000300047","article-title":"Comparative morphometry of the olfactory bulb, tract and stria in the human, dog and goat","volume":"29","author":"Kavoi","year":"2011","journal-title":"Int. J. Morphol."},{"key":"10.1016\/j.arr.2021.101416_bib0420","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1152\/jn.01036.2010","article-title":"The human brain representation of odor identification","volume":"108","author":"Kjelvik","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.arr.2021.101416_bib0425","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jns.2016.11.046","article-title":"Decision-making performance in Parkinson\u2019s disease correlates with lateral orbitofrontal volume","volume":"372","author":"Kobayakawa","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2021.101416_bib0430","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2020.00208","article-title":"Age-related olfactory dysfunction: epidemiology, pathophysiology, and clinical management","volume":"12","author":"Kondo","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0435","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2990.1999.00208.x","article-title":"\u03b2-Amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer\u2019s disease","volume":"25","author":"Kov\u00e1cs","year":"1999","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.arr.2021.101416_bib0440","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/chemse\/bjp018","article-title":"Test-retest reliability of the San Diego Odor Identification Test and comparison with the brief smell identification test","volume":"34","author":"Krantz","year":"2009","journal-title":"Chem. Senses"},{"key":"10.1016\/j.arr.2021.101416_bib0445","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0896-6273(00)81061-2","article-title":"Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1","volume":"25","author":"L\u2019Etoile","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2021.101416_bib0450","series-title":"Handbook of Olfaction and Gustation","first-page":"605","article-title":"Olfaction in nonhuman primates","author":"Laska","year":"2015"},{"key":"10.1016\/j.arr.2021.101416_bib0455","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1523\/JNEUROSCI.6394-11.2012","article-title":"Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb","volume":"32","author":"Lazarini","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0460","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/chemse\/bjp056","article-title":"Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice","volume":"34","author":"Lee","year":"2009","journal-title":"Chem. 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Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0480","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainresbull.2019.03.006","article-title":"Olfactory deficit is associated with mitral cell dysfunction in the olfactory bulb of P301S tau transgenic mice","volume":"148","author":"Li","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.arr.2021.101416_bib0485","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbrc.2019.03.110","article-title":"Construction of an irreversible allergic rhinitis-induced olfactory loss mouse model","volume":"513","author":"Liang","year":"2019","journal-title":"Biochem. Biophys. Res. 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Commun."},{"key":"10.1016\/j.arr.2021.101416_bib0500","doi-asserted-by":"crossref","first-page":"e2016","DOI":"10.1212\/WNL.0000000000011743","article-title":"Olfactory testing in Parkinson disease and REM behavior disorder: a machine learning approach","volume":"96","author":"Lo","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2021.101416_bib0505","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/jnnp-2020-325361","article-title":"Olfactory impairment as an early marker of Parkinson\u2019s disease in REM sleep behaviour disorder: a systematic review and meta-analysis","volume":"92","author":"Lyu","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.arr.2021.101416_bib0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.05.001.2008","article-title":"In vivo 3D digital atlas database of the adult C57BL\/6J mouse brain by magnetic resonance microscopy","volume":"2","author":"Ma","year":"2008","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.arr.2021.101416_bib0515","first-page":"8","article-title":"Buried food-seeking test for the assessment of olfactory detection in mice","author":"Machado","year":"2018","journal-title":"Bio-Protocol"},{"key":"10.1016\/j.arr.2021.101416_bib0520","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1212\/WNL.0000000000001265","article-title":"Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD","volume":"84","author":"Mahlknecht","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2021.101416_bib0525","first-page":"373","article-title":"Olfactory language and abstraction across cultures","author":"Majid","year":"2018","journal-title":"Philos. Trans. Biol. Sci."},{"key":"10.1016\/j.arr.2021.101416_bib0530","doi-asserted-by":"crossref","first-page":"241","DOI":"10.14639\/0392-100X-N0862","article-title":"Loss of smell in COVID-19 patients: a critical review with emphasis on the use of olfactory tests","volume":"40","author":"Marchese-Ragona","year":"2020","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"10.1016\/j.arr.2021.101416_bib0535","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.parkreldis.2018.04.028","article-title":"High prevalence of olfactory dysfunction in cervical dystonia","volume":"53","author":"Marek","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.arr.2021.101416_bib0540","first-page":"3","article-title":"Principles of glomerular organization in the human olfactory bulb \u2013 implications for odor processing","author":"Maresh","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2021.101416_bib0545","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11882-018-0796-4","article-title":"Olfactory dysfunction in neurodegenerative diseases","volume":"18","author":"Marin","year":"2018","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.arr.2021.101416_bib0550","doi-asserted-by":"crossref","first-page":"439","DOI":"10.18176\/jiaci.0451","article-title":"Pediatric Barcelona olfactory test 6 (pBOT-6): validation of a combined odor identification and threshold screening test in healthy Spanish children and adolescents","volume":"30","author":"Marino-Sanchez","year":"2020","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.arr.2021.101416_bib0555","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1152\/jn.00524.2007","article-title":"An olfacto-hippocampal network is dynamically involved in odor-discrimination learning","volume":"98","author":"Martin","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.arr.2021.101416_bib0560","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s13670-014-0080-y","article-title":"Olfactory dysfunction in the elderly: basic circuitry and alterations with normal aging and Alzheimer\u2019s disease","volume":"3","author":"Masurkar","year":"2014","journal-title":"Curr. Geriatr. Rep."},{"key":"10.1016\/j.arr.2021.101416_bib0565","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41593-020-00758-5","article-title":"Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19","volume":"24","author":"Meinhardt","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0570","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/13854046.2013.796406","article-title":"Normative performance on the Brief Smell Identification Test (BSIT) in a multi-ethnic bilingual cohort: a Project FRONTIER study","volume":"27","author":"Menon","year":"2013","journal-title":"Clin. 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Psychol."},{"key":"10.1016\/j.arr.2021.101416_bib0585","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archneur.55.1.84","article-title":"Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"55","author":"Mesholam","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2021.101416_bib0590","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1523\/JNEUROSCI.5133-04.2005","article-title":"Step-response analysis of chemotaxis in Caenorhabditis elegans","volume":"25","author":"Miller","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0595","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/acel.12541","article-title":"DNA polymerase beta decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer\u2019s disease","volume":"16","author":"Misiak","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2021.101416_bib0600","first-page":"3","article-title":"Apo E4 alleles and impaired olfaction as predictors of Alzheimer\u2019s disease","author":"Misiak","year":"2017","journal-title":"Clin Exp Psychol"},{"key":"10.1016\/j.arr.2021.101416_bib0605","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tins.2013.11.004","article-title":"Aging in the olfactory system","volume":"37","author":"Mobley","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2021.101416_bib0610","series-title":"Olfactory Bulb Mapping, Encyclopedia of Neuroscience","first-page":"71","author":"Mori","year":"2009"},{"key":"10.1016\/j.arr.2021.101416_bib0615","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41531-017-0039-8","article-title":"Optimizing olfactory testing for the diagnosis of Parkinson\u2019s disease: item analysis of the university of Pennsylvania smell identification test","volume":"4","author":"Morley","year":"2018","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.arr.2021.101416_bib0620","first-page":"10","article-title":"Postnatal guinea pig brain development, as revealed by magnetic resonance and diffusion kurtosis imaging","author":"Mullins","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.arr.2021.101416_bib0625","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41582-018-0097-5","article-title":"Olfactory and other sensory impairments in Alzheimer disease","volume":"15","author":"Murphy","year":"2019","journal-title":"Nat. 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Neurodegener."},{"key":"10.1016\/j.arr.2021.101416_bib0650","doi-asserted-by":"crossref","first-page":"101556","DOI":"10.1016\/j.isci.2020.101556","article-title":"Spatial transcriptomics reveals genes associated with dysregulated mitochondrial functions and stress signaling in Alzheimer disease","volume":"23","author":"Navarro","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.arr.2021.101416_bib0655","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1479-7364-4-2-107","article-title":"Evolutionary dynamics of olfactory receptor genes in chordates: interaction between environments and genomic contents","volume":"4","author":"Niimura","year":"2009","journal-title":"Hum. 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Neurodegener."},{"key":"10.1016\/j.arr.2021.101416_bib0670","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/bpa.12886","article-title":"IL-1beta\/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum","volume":"30","author":"Niu","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.arr.2021.101416_bib0675","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1073\/pnas.0702133104","article-title":"Evolutionary dynamics of olfactory receptor genes in Drosophila species","volume":"104","author":"Nozawa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2021.101416_bib0680","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fnins.2014.00102","article-title":"How neurogenesis finds its place in a hardwired sensory system","volume":"8","author":"Oboti","year":"2014","journal-title":"Front. 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Sci."},{"key":"10.1016\/j.arr.2021.101416_bib0695","first-page":"9","article-title":"The association between olfactory function and cognitive impairment in older persons with cognitive impairments: a cross-sectional study","author":"Park","year":"2021","journal-title":"Healthcare"},{"key":"10.1016\/j.arr.2021.101416_bib0700","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neuroscience.2011.09.005","article-title":"Olfactory bulb recovery following reversible deafferentation with repeated detergent application in the adult zebrafish","volume":"196","author":"Paskin","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2021.101416_bib0705","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.physbeh.2017.04.006","article-title":"Habituation and adaptation to odors in humans","volume":"177","author":"Pellegrino","year":"2017","journal-title":"Physiol. 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