{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:58:13Z","timestamp":1792681093348,"version":"4.5.0"},"reference-count":404,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.arr.2022.101592","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T18:22:21Z","timestamp":1645294941000},"page":"101592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Comorbidity of osteoporosis and Alzheimer\u2019s disease: Is `AKT `-ing on cellular glucose uptake the missing link?"],"prefix":"10.1016","volume":"76","author":[{"given":"K.","family":"Fehsel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Christl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101592_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2022.151844","article-title":"Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases","volume":"124","author":"Abedpoor","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.arr.2022.101592_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/bs.vh.2016.02.006","article-title":"Function and change with aging of \u03b1-klotho in the kidney","volume":"101","author":"Akasaka-Manya","year":"2016","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.arr.2022.101592_bib3","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1021\/jf049295g","article-title":"Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat","volume":"52","author":"Al-Awwadi","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.arr.2022.101592_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/dmcn.12868","article-title":"Morbidity and medication in a large population of individuals with Down syndrome compared to the general population","volume":"58","author":"Alexander","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fneur.2019.00239","article-title":"The relationships between vitamin K and cognition: a review of current evidence","volume":"10","author":"Alisi","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib6","article-title":"Loss of nuclear and membrane estrogen receptor-\u03b1 differentially impairs insulin secretion and action in male and female mice","author":"Allard","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.arr.2022.101592_bib7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.redox.2014.03.004","article-title":"Role of GLUT1 in regulation of reactive oxygen species","volume":"2","author":"Andrisse","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2022.101592_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ijdevneu.2004.07.006","article-title":"Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology","volume":"22","author":"Apelt","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib9","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1002\/1529-0131(200112)44:12<2790::AID-ART466>3.0.CO;2-X","article-title":"Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis","volume":"44","author":"Armour","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.arr.2022.101592_bib10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/1440-1681.12717","article-title":"Hypoxia-inducible factors as neuroprotective agent in Alzheimer\u2019s disease","volume":"44","author":"Ashok","year":"2017","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"10.1016\/j.arr.2022.101592_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2012.10.558","article-title":"Metallostasis in Alzheimer's disease","volume":"62","author":"Ayton","year":"2014","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00213-017-4547-3","article-title":"Bi-phasic regulation of glycogen content in astrocytes via Cav-1\/PTEN\/PI3K\/AKT\/GSK-3beta pathway by fluoxetine","volume":"234","author":"Bai","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.arr.2022.101592_bib14","doi-asserted-by":"crossref","first-page":"17497","DOI":"10.1074\/jbc.M409332200","article-title":"Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast","volume":"280","author":"Bai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib15","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1074\/jbc.R117.803239","article-title":"Astrocytic glycogen metabolism in the healthy and diseased brain","volume":"293","author":"Bak","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib16","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1210\/en.2004-0619","article-title":"Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta","volume":"145","author":"Baker","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jsbmb.2019.01.012","article-title":"Long-term selective estrogen receptor-beta agonist treatment modulates gene expression in bone and bone marrow of ovariectomized rats","volume":"188","author":"Balla","year":"2019","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.molcel.2019.03.031","article-title":"ER and nutrient stress promote assembly of respiratory chain supercomplexes through the PERK-eIF2\u03b1 axis","volume":"74","author":"Balsa","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2022.101592_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.freeradbiomed.2016.10.508","article-title":"HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology","volume":"111","author":"Barone","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib20","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.7150\/ijms.26774","article-title":"Estrogen receptor 1 (ESR1) enhances Slc2a4\/GLUT4 expression by a SP1 cooperative mechanism","volume":"15","author":"Barreto-Andrade","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.arr.2022.101592_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2018.06.009","article-title":"Hydrogen sulfide epigenetically mitigates bone loss through OPG\/RANKL regulation during hyperhomocysteinemia in mice","volume":"114","author":"Behera","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib22","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1373\/clinchem.2004.037531","article-title":"Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases?","volume":"50","author":"Bennermo","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib23","doi-asserted-by":"crossref","first-page":"41954","DOI":"10.1074\/jbc.M203492200","article-title":"Myo-inositol monophosphatase is an activated target of calbindin D28k","volume":"277","author":"Berggard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib24","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1126\/science.290.5500.2302","article-title":"Evidence for genetic linkage of Alzheimer's disease to chromosome 10q","volume":"290","author":"Bertram","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101592_bib25","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.biopha.2019.01.036","article-title":"Antidiabetic role of a novel protein from garlic via NO in expression of Glut-4\/insulin in liver of alloxan induced diabetic mice","volume":"111","author":"Bhattacharya","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2022.101592_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exer.2018.03.015","article-title":"Expression and regulation of alarmin cytokine IL-1\u03b1 in human retinal pigment epithelial cells","volume":"172","author":"Bian","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.arr.2022.101592_bib27","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1016\/S0021-9258(18)77387-0","article-title":"Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters","volume":"265","author":"Bird","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cellsig.2017.10.018","article-title":"Involvement of glucose related energy crisis and endoplasmic reticulum stress: insinuation of streptozotocin induced Alzheimer\u2019s like pathology","volume":"42","author":"Biswas","year":"2018","journal-title":"Cell Signal."},{"key":"10.1016\/j.arr.2022.101592_bib29","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/ncb1063","article-title":"Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis","volume":"5","author":"Boehning","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2022.101592_bib30","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bone.2018.11.002","article-title":"Use it or lose it to age: a review of bone and muscle communication","volume":"120","author":"Bonewald","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jbmr.1836","article-title":"An energetic orphan in an endocrine tissue: a revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage","volume":"28","author":"Bonnelye","year":"2013","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib32","first-page":"10","article-title":"Vitamin K antagonists and cognitive decline in older adults: a 24-month follow-up","author":"Brangier","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2022.101592_bib33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.steroids.2007.02.003","article-title":"Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications","volume":"72","author":"Brann","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.arr.2022.101592_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(99)00664-3","article-title":"Parathyroid hormone-related protein protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux","volume":"274","author":"Brines","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101592_bib35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0014-4886(03)00094-3","article-title":"Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex","volume":"182","author":"Bu","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib36","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1074\/jbc.RA117.000808","article-title":"High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice","volume":"293","author":"Burchfield","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib37","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1523\/JNEUROSCI.23-23-08212.2003","article-title":"Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons","volume":"23","author":"Burkhalter","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbabio.2018.03.006","article-title":"Estrogen receptor beta modulates permeability transition in brain mitochondria","volume":"1859","author":"Burstein","year":"2018","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101592_bib39","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s10495-013-0930-7","article-title":"Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7- and calpain-mediated caspase-12 activation","volume":"19","author":"de la Cadena","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.arr.2022.101592_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10534-018-0081-y","article-title":"Efficacy of bovine lactoferrin in the post-surgical treatment of patients suffering from bisphosphonate-related osteonecrosis of the jaws: an open-label study","volume":"31","author":"Calvani","year":"2018","journal-title":"Biometals"},{"key":"10.1016\/j.arr.2022.101592_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/JME-17-0041","article-title":"Estradiol-induced regulation of GLUT4 in 3T3-L1 cells: involvement of ESR1 and AKT activation","volume":"59","author":"Campello","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.mcn.2003.10.008","article-title":"Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus","volume":"25","author":"Cardona-Gomez","year":"2004","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neurobiolaging.2021.04.012","article-title":"Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics","volume":"105","author":"Carlyle","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101592_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2004.02.050","article-title":"The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer\u2019s disease","volume":"490","author":"Carro","year":"2004","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib45","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nm1202-793","article-title":"Serum insulin-like growth factor I regulates brain amyloid-beta levels","volume":"8","author":"Carro","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2022.101592_bib46","first-page":"131","article-title":"Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin","volume":"8","author":"Carro","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2022.101592_bib47","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s12035-018-1111-z","article-title":"Thyroid hormone supplementation restores spatial memory, hippocampal markers of neuroinflammation, plasticity-related signaling molecules, and \u03b2-amyloid peptide load in hypothyroid rats","volume":"56","author":"Chaalal","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101592_bib48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11154-015-9312-5","article-title":"Bone, brain & beyond","volume":"2","author":"Chamouni","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.arr.2022.101592_bib49","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.jagp.2021.02.001","article-title":"Association of depressive symptoms with postoperative delirium and CSF biomarkers for Alzheimer\u2019s disease among hip fracture patients","volume":"29","author":"Chan","year":"2021","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/0256-4947.71062","article-title":"Association of interleukin-1 beta (-511C\/T) polymorphisms with osteoporosis in postmenopausal women","volume":"30","author":"Chao","year":"2010","journal-title":"Ann. Saudi Med."},{"key":"10.1016\/j.arr.2022.101592_bib51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.yexcr.2016.12.028","article-title":"Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke","volume":"351","author":"Chen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.arr.2022.101592_bib52","first-page":"182","article-title":"Status of bone strength and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes","volume":"2019 26","author":"Chen","year":"2018","journal-title":"Menopause"},{"key":"10.1016\/j.arr.2022.101592_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-017-0004-5","article-title":"mTOR signaling in skeletal development and disease","volume":"6","author":"Chen","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.arr.2022.101592_bib54","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/jgs.14537","article-title":"Genetic polymorphisms in estrogen metabolic pathway associated with risks of Alzheimer\u2019s disease: evidence from a southern Chinese population","volume":"65","author":"Chen","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101592_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.113043","article-title":"AMPK: a bridge between diabetes mellitus and Alzheimer\u2019s disease","volume":"400","author":"Chen","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2022.101592_bib56","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fphar.2017.00334","article-title":"Berberine ameliorates diabetes-associated cognitive decline through modulation of aberrant inflammation response and insulin signaling pathway in DM rats","volume":"8","author":"Chen","year":"2017","journal-title":"Front Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-2005-7104","article-title":"Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia","volume":"7","author":"Chen","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib58","doi-asserted-by":"crossref","DOI":"10.1530\/JME-19-0003","article-title":"Lactoferrin ameliorates aging-suppressed osteogenesis via IGF1 signaling","author":"Chen","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib59","doi-asserted-by":"crossref","first-page":"e3739","DOI":"10.1210\/clinem\/dgab213","article-title":"Sex-dependent association of vitamin D with insulin resistance in humans","volume":"106","author":"Chen","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib60","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/febs.14754","article-title":"Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN\/Akt\/GSK-3\u03b2\/\u03b2-catenin axis","volume":"286","author":"Chen","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.arr.2022.101592_bib61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer\u2019s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101592_bib62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1096\/fsb2fj000398com","article-title":"Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex","volume":"15","author":"Cheng","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101592_bib63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.drugalcdep.2019.01.025","article-title":"The effect of alcohol on osteoporosis: a systematic review and meta-analysis","volume":"197","author":"Cheraghi","year":"2019","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.arr.2022.101592_bib64","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1007\/s12035-021-02297-x","article-title":"Impact of genetic risk factors for Alzheimer\u2019s disease on brain glucose metabolism","volume":"58","author":"Cho","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101592_bib65","article-title":"Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1\/2\u03b1 independent manner","volume":"8","author":"Choi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib66","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jsbmb.2004.03.007","article-title":"Biological actions and mechanism of action of calbindin in the process of apoptosis","volume":"89\u201390","author":"Christakos","year":"2004","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib67","article-title":"Background to new treatments for COVID-19, including its chronicity, through altering elements of the cytokine storm","author":"Clark","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.arr.2022.101592_bib68","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3389\/fphys.2017.00796","article-title":"Presenilin 2-dependent maintenance of mitochondrial oxidative capacity and morphology","volume":"8","author":"Contino","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.arr.2022.101592_bib69","article-title":"Hormone replacement therapy with L-thyroxine promotes working memory and concentration in thyroidectomized female patients after differentiated thyroid carcinoma","author":"Cordes","year":"2019","journal-title":"Int J. Psychiatry Med."},{"key":"10.1016\/j.arr.2022.101592_bib70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.psyneuen.2015.08.005","article-title":"Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?","volume":"62","author":"Cox","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib71","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1139\/cjpp-2018-0277","article-title":"Klotho protein inhibits H2O2-induced oxidative injury in endothelial Cells via regulation of PI3K\/Akt\/Nrf2\/HO-1 Pathways","volume":"97","author":"Cui","year":"2018","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib72","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1210\/en.2002-220597","article-title":"Inducible nitric oxide synthase mediates bone loss in ovariectomized mice","volume":"144","author":"Cuzzocrea","year":"2003","journal-title":"Endocrinology"},{"issue":"118","key":"10.1016\/j.arr.2022.101592_bib73","article-title":"Recruitment of pro-IL-1\u03b1 to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation","volume":"5","author":"Dagvadorj","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib74","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3233\/JAD-160658","article-title":"Early evidence of low bone density and decreased serotonergic synthesis in the dorsal raphe of a tauopathy model of Alzheimer\u2019s disease","volume":"55","author":"Dengler-Crish","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib75","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/ars.2016.6759","article-title":"The triangle of death in alzheimer\u2019s disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics","volume":"26","author":"Di Domenico","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2022.101592_bib76","doi-asserted-by":"crossref","first-page":"E989","DOI":"10.1152\/ajpendo.00550.2004","article-title":"Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women","volume":"288","author":"Dick","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib77","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12017-007-8011-0","article-title":"Western style diet impairs entrance of blood-borne insulin-like growth factor-1 into the brain","volume":"9","author":"Dietrich","year":"2007","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jnutbio.2017.09.022","article-title":"Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1\/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose","volume":"52","author":"Dihingia","year":"2018","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.arr.2022.101592_bib79","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1089\/jir.2014.0194","article-title":"Obesity-associated inflammatory cytokines and prostaglandin E2 stimulate glucose transporter mRNA expression and glucose uptake in primary human adipose stromal cells","volume":"35","author":"Docanto","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.arr.2022.101592_bib80","first-page":"3238","article-title":"Anti-microRNA-132 causes sevoflurane\u2011induced neuronal apoptosis via the PI3K\/AKT\/FOXO3a pathway","volume":"42","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib81","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1475-2840-13-74","article-title":"Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt\/eNOS-dependent pathway","volume":"13","author":"Dou","year":"2014","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.arr.2022.101592_bib82","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ni.3659","article-title":"Postprandial macrophage-derived IL-1\u03b2 stimulates insulin, and both synergistically promote glucose disposal and inflammation","volume":"18","author":"Dror","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2022.101592_bib83","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuropharm.2018.01.044","article-title":"Brain insulin signalling, glucose metabolism and females\u2019 reproductive aging: a dangerous triad in Alzheimer\u2019s disease","volume":"136","author":"Duarte","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2022.101592_bib84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuro.2018.03.001","article-title":"Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats","volume":"66","author":"Dubey","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.arr.2022.101592_bib85","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nm1712","article-title":"Dimorphic effects of Notch signaling in bone homeostasis","volume":"14","author":"Engin","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2022.101592_bib86","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/jbmr.3608","article-title":"Poor vitamin K status is associated with low bone mineral density and increased fracture risk in end-stage renal disease","volume":"34","author":"Evenepoel","year":"2019","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib87","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jdiacomp.2017.09.004","article-title":"Decreased serum undercarboxylated osteocalcin is associated with cognitive impairment in male patients with type 2 diabetes","volume":"32","author":"Fang","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.arr.2022.101592_bib88","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00702-016-1620-8","article-title":"Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences","volume":"123","author":"Fehsel","year":"2016","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.arr.2022.101592_bib89","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0167-4889(02)00390-7","article-title":"Distinct regulation of glucose transport and GLUT1\/GLUT3 transporters by glucose deprivation and IGF-I in chromaffin cells","volume":"1593","author":"Fladeby","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101592_bib90","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1523\/JNEUROSCI.4998-04.2005","article-title":"Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors","volume":"25","author":"Floden","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib91","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2015.11.020","article-title":"Long-term cognitive effects of glucocorticoid excess in Cushing's syndrome","volume":"65","author":"Forget","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib92","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.arr.2022.101592_bib93","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molmed.2010.03.003","article-title":"Inflammatory networks during cellular senescence: causes and consequences","volume":"16","author":"Freund","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib94","article-title":"Vitamin D levels are associated with metabolic syndrome in adolescents and young adults: The BCAMS study","author":"Fu","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.arr.2022.101592_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204406","article-title":"Biochemical evidence of cell starvation in diabetic hemodialysis patients","volume":"13","author":"Fujiwara","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib96","doi-asserted-by":"crossref","first-page":"26383","DOI":"10.1074\/jbc.M115.664367","article-title":"Effect of cholesterol reduction on receptor signaling in neurons","volume":"290","author":"Fukui","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib97","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.phrs.2014.06.014","article-title":"Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism","volume":"87","author":"Gambari","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.arr.2022.101592_bib98","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1073\/pnas.0409854102","article-title":"Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription","volume":"102","author":"Garb\u00e1n","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib99","first-page":"18","article-title":"Unmasking delirium","volume":"102","author":"Gillis","year":"2006","journal-title":"Can. Nurse"},{"key":"10.1016\/j.arr.2022.101592_bib100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.taap.2013.07.001","article-title":"Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats","volume":"272","author":"Gilmour","year":"2013","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib101","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2017.03.038","article-title":"Changes in cerebral [18F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism","volume":"327","author":"Gispert","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2022.101592_bib102","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fncel.2015.00297","article-title":"Monomeric \u00df-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons","volume":"9","author":"Giuffrida","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1533317506295889","article-title":"The influence of beta-blockers on delayed memory function in people with cognitive impairment","volume":"22","author":"Gliebus","year":"2007","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"10.1016\/j.arr.2022.101592_bib104","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1124\/mol.58.6.1389","article-title":"Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress","volume":"58","author":"Gnad","year":"2000","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib105","doi-asserted-by":"crossref","first-page":"8152373","DOI":"10.1155\/2018\/8152373","article-title":"Neuroprotective mechanisms of resveratrol in Alzheimer\u2019s disease: role of SIRT1","author":"Gomes","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.arr.2022.101592_bib106","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2022.101592_bib107","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fnagi.2014.00095","article-title":"Resveratrol and Alzheimer\u2019s disease: message in a bottle on red wine and cognition","volume":"6","author":"Granzotto","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib108","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ajcn\/81.3.611","article-title":"Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons","volume":"81","author":"Grassi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.arr.2022.101592_bib109","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jbmr.2757","article-title":"Hydrogen sulfide is a novel regulator of bone formation implicated in the bone loss induced by estrogen deficiency","volume":"31","author":"Grassi","year":"2016","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib110","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3233\/JAD-171047","article-title":"Calpain I activation causes GLUT3 proteolysis and downregulation of O-GlcNAcylation in Alzheimer\u2019s disease brain","volume":"62","author":"Gu","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib111","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bone.2017.11.020","article-title":"Osteocalcin improves insulin resistance and inflammation in obese mice: participation of white adipose tissue and bone","volume":"115","author":"Guedes","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib112","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biochi.2013.12.003","article-title":"Alkaline pH activates the transport activity of GLUT1 in L929 fibroblast cells","volume":"99","author":"Gunnink","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.arr.2022.101592_bib113","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1038\/npp.2017.8","article-title":"Intranasal lactoferrin enhances \u03b1-secretase-dependent amyloid precursor protein processing via the ERK1\/2-CREB and HIF-1\u03b1 pathways in an Alzheimer\u2019s disease mouse model","volume":"42","author":"Guo","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.arr.2022.101592_bib114","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bone.2018.10.025","article-title":"SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice","volume":"120","author":"Guo","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139395","article-title":"Iron chelation inhibits osteoclastic differentiation in vitro and in Tg2576 mouse model of Alzheimer\u2019s disease","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib116","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mehy.2015.12.023","article-title":"Dkk1: a promising molecule to connect Alzheimer\u2019s disease and osteoporosis","volume":"88","author":"Guo","year":"2016","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.arr.2022.101592_bib117","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fnmol.2018.00343","article-title":"Osteocalcin ameliorates motor dysfunction in a 6-hydroxydopamine-induced Parkinson\u2019s disease rat model through AKT\/GSK3\u03b2 signaling","volume":"11","author":"Guo","year":"2018","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib118","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1469-1809.2011.00663.x","article-title":"Mitochondria-wide association study of common variants in osteoporosis","volume":"75","author":"Guo","year":"2011","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.arr.2022.101592_bib119","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3940(02)00095-2","article-title":"Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer\u2019s dementia and following stimulation with beta-amyloid 1-42 in vitro","volume":"322","author":"Haas","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101592_bib120","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jcsm.12283","article-title":"hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway","volume":"9","author":"Halon-Golabek","year":"2018","journal-title":"J. Cachex. Sarcopenia Muscle"},{"key":"10.1016\/j.arr.2022.101592_bib121","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00125-004-1623-0","article-title":"Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes","volume":"48","author":"Hamid","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2022.101592_bib122","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00125-014-3269-x","article-title":"Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes","volume":"57","author":"Hamilton","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2022.101592_bib123","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000338397","article-title":"Estrogen receptors and the regulation of neural stress responses","volume":"96","author":"Handa","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib124","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1136\/jnnp.2003.030866","article-title":"A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer\u2019s disease","volume":"75","author":"Hayes","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib125","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0306-4522(03)00167-2","article-title":"17 Beta-oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus","volume":"120","author":"Haynes","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101592_bib126","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.pharep.2016.05.006","article-title":"Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K\/Akt pathway in the brain of APP\/PS1 transgenic mouse","volume":"68","author":"He","year":"2016","journal-title":"Pharm. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib127","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fnagi.2018.00191","article-title":"Metabolic and vascular iImaging biomarkers in Down syndrome provide unique insights into brain aging and Alzheimer disease pathogenesis","volume":"10","author":"Head","year":"2018","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib128","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/sj.mp.4001553","article-title":"Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI","volume":"9","author":"den Heijer","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577290","article-title":"Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways","volume":"345","author":"Hima","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2022.101592_bib130","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/419106","article-title":"Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats","volume":"2015","author":"Hirata","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.arr.2022.101592_bib131","first-page":"245","article-title":"Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures","volume":"10","author":"Holmlund","year":"2002","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.arr.2022.101592_bib132","doi-asserted-by":"crossref","first-page":"20978","DOI":"10.1074\/jbc.M500526200","article-title":"Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron","volume":"280","author":"Honda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib133","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1097\/00029330-200710010-00013","article-title":"Influence of blood glucose on the expression of glucose trans-porter proteins 1 and 3 in the brain of diabetic rats","volume":"120","author":"Hou","year":"2007","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.arr.2022.101592_bib134","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/bcpt.13087","article-title":"Sevoflurane impairs insulin secretion and tissue-specific glucose uptake in vivo","volume":"123","author":"H\u00f8yer","year":"2018","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.arr.2022.101592_bib135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12974-017-0791-z","article-title":"Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer\u2019s disease","volume":"14","author":"Huang","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2022.101592_bib136","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/804260","article-title":"Protein phosphatase 2A mediates oxidative stress induced apoptosis in osteoblasts","volume":"2015","author":"Huang","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.arr.2022.101592_bib137","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1096\/fj.201700447rr","article-title":"Presenilin1\/\u03b3-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15","volume":"32","author":"Huang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101592_bib138","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.bbadis.2015.06.016","article-title":"Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease","volume":"1852","author":"Huss","year":"2015","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101592_bib139","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0167-4889(00)00109-9","article-title":"Alternative glycosylation of the insulin receptor prevents oligomerization and acquisition of insulin-dependent tyrosine kinase activity","volume":"1499","author":"Hwang","year":"2000","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101592_bib140","doi-asserted-by":"crossref","first-page":"21239","DOI":"10.1074\/jbc.M312771200","article-title":"Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone","volume":"279","author":"Hwang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib141","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1212\/01.WNL.0000118208.16939.60","article-title":"Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease","volume":"62","author":"Iivonen","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101592_bib142","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/WNL.0000000000003696","article-title":"Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study","volume":"88","author":"Imtiaz","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101592_bib143","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1001\/jama.292.17.2105","article-title":"Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes","volume":"292","author":"Ioannidis","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2022.101592_bib144","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s10020-018-0004-y","article-title":"Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets","volume":"24","author":"Izzo","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib145","article-title":"Genetic mutations of APOEepsilon4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer\u2019s disease","volume":"10","author":"Jabeen","year":"2021","journal-title":"J. Biochem Mol. Toxicol. Nov."},{"key":"10.1016\/j.arr.2022.101592_bib146","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bbrc.2010.12.080","article-title":"O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-\u03b2 precursor protein (APP)","volume":"404","author":"Jacobsen","year":"2011","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.arr.2022.101592_bib147","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.cell.2016.08.010","article-title":"Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity","volume":"166","author":"Jais","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101592_bib148","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1359\/JBMR.040716","article-title":"Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trial","volume":"19","author":"Jamal","year":"2004","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib149","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/cyto.1995.1007","article-title":"Central administration of IL-1 alpha increases glucose uptake by muscle","volume":"7","author":"Jarrous","year":"1995","journal-title":"Cytokine"},{"key":"10.1016\/j.arr.2022.101592_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.699623","article-title":"Crosstalk between dysfunctional mitochondria and inflammation in glaucomatous neurodegeneration","volume":"12","author":"Jassim","year":"2021","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.arr.2022.101592_bib151","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0953-6205(02)00183-8","article-title":"Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to -6 and their relationship to bone metabolism in osteoporosis patients","volume":"14","author":"Jehle","year":"2003","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.arr.2022.101592_bib152","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/ajcn\/nqy122","article-title":"A pattern with vitamin D3 (10 \u00b5g\/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial","volume":"108","author":"Jennings","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.arr.2022.101592_bib153","first-page":"99","article-title":"Patients with Alzheimer's disease who carry the APOE \u03b54 allele benefit more from physical exercise","volume":"5","author":"Jensen","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2022.101592_bib154","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025404","article-title":"Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice","volume":"6","author":"Jeong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib155","first-page":"10","article-title":"Osteoprotegerin disruption attenuates HySu-induced pulmonary hypertension through integrin \u03b1v\u03b23\/FAK\/AKT pathway suppression","author":"Jia","year":"2017","journal-title":"Circ. Cardiovasc Genet."},{"key":"10.1016\/j.arr.2022.101592_bib156","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1089\/ars.2009.2576","article-title":"Iron and menopause: does increased iron affect the health of postmenopausal women?","volume":"11","author":"Jian","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.arr.2022.101592_bib157","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1139\/Y10-006","article-title":"Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart","volume":"88","author":"Jiang","year":"2010","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib158","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jep.2014.10.062","article-title":"Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms","volume":"159","author":"Jiang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2022.101592_bib159","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbrc.2004.01.093","article-title":"Differential regulation of phosphatidylinositol 3-kinase\/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced oxidative stress in the kidney of young and old rats","volume":"315","author":"Jin","year":"2004","journal-title":"Biochem. Biophys. Res Commun."},{"key":"10.1016\/j.arr.2022.101592_bib160","first-page":"189","article-title":"A population-based study on the association between dementia and hip fractures in 85-year olds","volume":"8","author":"Johansson","year":"1996","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.arr.2022.101592_bib161","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpsychires.2016.02.002","article-title":"Altered DNA methylation of glucose transporter 1 and glucose transporter 4 in patients with major depressive disorder","volume":"76","author":"Kahl","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.arr.2022.101592_bib162","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbmr.2909","article-title":"A novel, direct NO donor regulates osteoblast and osteoclast functions and increases bone mass in ovariectomized mice","volume":"32","author":"Kalyanaraman","year":"2017","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib163","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1359\/JBMR.040306","article-title":"Nongenomic androgen activation of phosphatidylinositol 3-kinase\/Akt signaling pathway in MC3T3-E1 osteoblasts","volume":"19","author":"Kang","year":"2004","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib164","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jsbmb.2015.07.002","article-title":"Osteoprotective effects of estrogen membrane receptor GPR30 in ovariectomized rats","volume":"154","author":"Kang","year":"2015","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib165","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2017.08.008","article-title":"Glucose metabolism in bone","volume":"115","author":"Karner","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib166","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/S1470-2045(18)30938-0","article-title":"Pharmacologic management of cognitive impairment induced by cancer therapy","volume":"20","author":"Karschnia","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.arr.2022.101592_bib167","doi-asserted-by":"crossref","first-page":"346","DOI":"10.5414\/CPP41346","article-title":"Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation and cellular redox state","volume":"41","author":"Kawano","year":"2003","journal-title":"Int. J. Clin. Pharm. Ther."},{"key":"10.1016\/j.arr.2022.101592_bib168","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-150348","article-title":"Human ApoE isoforms differentially modulate glucose and amyloid metabolic pathways in female brain: evidence of the mechanism of neuroprotection by ApoE2 and implications for Alzheimer\u2019s disease prevention and early intervention","volume":"48","author":"Keeney","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib169","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1210\/jc.2014-3277","article-title":"11\u03b2-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men","volume":"100","author":"Kilgour","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib170","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2015.11.034","article-title":"Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons","volume":"468","author":"Kim","year":"2015","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.arr.2022.101592_bib171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.07.093","article-title":"Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro","volume":"1027","author":"Kim","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101592_bib172","first-page":"8","article-title":"Association of hemoglobin level with fracture: a nationwide cohort study","author":"Kim","year":"2021","journal-title":"J. Bone Min. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib173","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.625511","article-title":"Blood hemoglobin, in-vivo alzheimer pathologies, and cognitive impairment: a cross-sectional Study","volume":"13","author":"Kim","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib174","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00394-017-1604-y","article-title":"Cognitive impairment is associated with elevated serum homocysteine levels among older adults","volume":"58","author":"Kim","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.arr.2022.101592_bib175","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/00365510802632163","article-title":"Type-2 diabetes down-regulates glucose transporter proteins and genes of the human blood leukocytes","volume":"69","author":"Kipmen-Korgun","year":"2009","journal-title":"Scand. J. Clin. Lab Invest."},{"key":"10.1016\/j.arr.2022.101592_bib176","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00223-006-0059-6","article-title":"The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures","volume":"80","author":"Knudsen","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.arr.2022.101592_bib177","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.jalz.2018.05.017","article-title":"N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-\u03b2 oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease","volume":"14","author":"Kodis","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2022.101592_bib178","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1016\/j.lfs.2004.04.048","article-title":"Fas\/CD95 is associated with glucocorticoid-induced osteocyte apoptosis","volume":"75","author":"Kogianni","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101592_bib179","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1073\/pnas.0406874102","article-title":"Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium\/ calcineurin\/NFAT pathway in osteoclasts","volume":"102","author":"Komarova","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib180","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11011-008-9100-y","article-title":"Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats","volume":"23","author":"Konat","year":"2008","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2022.101592_bib181","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1472-6874-13-36","article-title":"Preference for wine is associated with lower hip fracture incidence in post-menopausal women","volume":"13","author":"Kubo","year":"2013","journal-title":"BMC Women\u2019s Health"},{"key":"10.1016\/j.arr.2022.101592_bib182","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jphs.2016.06.005","article-title":"Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer\u2019s disease","volume":"131","author":"Kubota","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.arr.2022.101592_bib183","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3233\/JAD-181017","article-title":"Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-\/- Mice","volume":"68","author":"Kuhla","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib184","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The Klotho proteins in health and disease","volume":"15","author":"Kuro-O","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.arr.2022.101592_bib185","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1007\/s12035-020-02253-1","article-title":"Telmisartan inhibits the NLRP3 inflammasome by activating the PI3K pathway in neural stem cells injured by oxygen-glucose deprivation","volume":"58","author":"Kwon","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101592_bib186","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3233\/JAD-190060","article-title":"O-GlcNAcylation of amyloid-\u03b2 protein precursor by insulin signaling reduces amyloid-\u03b2 production","volume":"69","author":"Kwon","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib187","doi-asserted-by":"crossref","first-page":"18504","DOI":"10.1074\/jbc.M313543200","article-title":"A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression","volume":"279","author":"Lagani\u00e8re","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib188","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-201X.2004.01303.x","article-title":"Inhibited anabolic effect of insulin-like growth factor-I on stromal bone marrow cells in endothelial nitric oxide synthase-knockout mice","volume":"182","author":"Lagumdzija","year":"2004","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.arr.2022.101592_bib189","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1111\/adb.12433","article-title":"Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling","volume":"22","author":"Lao-Peregr\u00edn","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib190","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3389\/fimmu.2019.01789","article-title":"Metabolic reprograming of cystic fibrosis macrophages via the IRE1\u03b1 arm of the unfolded protein response results in exacerbated inflammation","volume":"10","author":"Lara-Reyna","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2022.101592_bib191","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2165\/00002512-200118100-00001","article-title":"Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging","volume":"18","author":"Le","year":"2001","journal-title":"Drugs Aging"},{"key":"10.1016\/j.arr.2022.101592_bib192","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12937-018-0387-1","article-title":"Role of milk and dairy intake in cognitive function in older adults: a systematic review and meta-analysis","volume":"17","author":"Lee","year":"2018","journal-title":"Nutr. J."},{"key":"10.1016\/j.arr.2022.101592_bib193","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy metabolism of the osteoblast: implications for osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.arr.2022.101592_bib194","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2337\/diabetes.54.4.1214","article-title":"A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.","volume":"54","author":"Lehman","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.arr.2022.101592_bib195","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2022.101592_bib196","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.abb.2007.03.005","article-title":"Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1","volume":"463","author":"Li","year":"2007","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.arr.2022.101592_bib197","doi-asserted-by":"crossref","first-page":"16634","DOI":"10.1002\/jcb.28922","article-title":"The role of resveratrol in bone marrow-derived mesenchymal stem cells from patients with osteoporosis","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.arr.2022.101592_bib198","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100952R","article-title":"Soluble Klotho-integrin beta1\/ERK1\/2 pathway ameliorates myocardial fibrosis in diabetic cardiomyopathy","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101592_bib199","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1567205015666181031145045","article-title":"Intranasal insulin prevents anesthesia-induced cognitive impairments in aged mice","volume":"16","author":"Li","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101592_bib200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000501294","article-title":"Hydrogen sulfide ameliorates cognitive dysfunction in formaldehyde-exposed rats: involvement in the upregulation of brain-derived neurotrophic factor","volume":"79","author":"Li","year":"2020","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.arr.2022.101592_bib201","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.niox.2014.12.007","article-title":"Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes","volume":"46","author":"Liang","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.arr.2022.101592_bib202","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1074\/jbc.M410610200","article-title":"Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling","volume":"280","author":"Liberman","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib203","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12192-014-0551-2","article-title":"Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer\u2019s A\u03b2 peptide ion channel","volume":"20","author":"Lin","year":"2015","journal-title":"Cell Stress Chaperon."},{"key":"10.1016\/j.arr.2022.101592_bib204","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/364626a0","article-title":"A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds","volume":"364","author":"Lipton","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.arr.2022.101592_bib205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1089\/brain.2018.0578","article-title":"Joint pairing and structured mapping of convolutional brain morphological multiplexes for early dementia diagnosis","volume":"9","author":"Lisowska","year":"2018","journal-title":"Brain Connect"},{"key":"10.1016\/j.arr.2022.101592_bib206","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12640-016-9671-z","article-title":"Sevoflurane-induced endoplasmic reticulum stress contributes to neuroapoptosis and BACE-1 expression in the developing brain: the role of eIF2alpha","volume":"31","author":"Liu","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2022.101592_bib207","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S2225-4110(16)30087-6","article-title":"The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats","volume":"2","author":"Liu","year":"2012","journal-title":"J. Tradit. Complement Med."},{"key":"10.1016\/j.arr.2022.101592_bib208","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2174\/15672050113109990149","article-title":"Alzheimer\u2019s disease is associated with increased risk of osteoporosis: the chongqing aging study","volume":"13","author":"Liu","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101592_bib209","doi-asserted-by":"crossref","first-page":"10804","DOI":"10.1073\/pnas.0400348101","article-title":"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer\u2019s disease","volume":"101","author":"Liu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib210","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1093\/brain\/awp099","article-title":"Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease","volume":"132","author":"Liu","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.arr.2022.101592_bib211","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1096\/fj.201900393RR","article-title":"Hydrogen sulfide protects against particle-induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening","volume":"34","author":"Liu","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101592_bib212","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3892\/etm.2013.978","article-title":"Hyperglycemia induces endoplasmic reticulum stress-dependent CHOP expression in osteoblasts","volume":"5","author":"Liu","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.arr.2022.101592_bib213","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.febslet.2007.12.035","article-title":"Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease","volume":"582","author":"Liu","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2022.101592_bib214","article-title":"High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib215","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1359\/jbmr.040909","article-title":"The COMT val158met polymorphism is associated with peak BMD in men","volume":"19","author":"Lorentzon","year":"2004","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib216","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00702-009-0241-x","article-title":"Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer\u2019s disease","volume":"116","author":"Luckhaus","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2022.101592_bib217","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1601-5215.2002.51007.x","article-title":"Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures","volume":"51","author":"Lui","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101592_bib218","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1078\/0940-2993-00280","article-title":"Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro","volume":"54","author":"Lupp","year":"2003","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.arr.2022.101592_bib219","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(02)03280-8","article-title":"Aberrant expression of NOS isoforms in Alzheimer\u2019s disease is structurally related to nitrotyrosine formation","volume":"953","author":"L\u00fcth","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101592_bib220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.etap.2017.03.017","article-title":"Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k\/Akt\/GSK3\u03b2 pathway in the hippocampus of neonatal rats","volume":"52","author":"Lv","year":"2017","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030010","article-title":"Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery","volume":"7","author":"Lyons","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib222","first-page":"9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.arr.2022.101592_bib223","doi-asserted-by":"crossref","DOI":"10.1177\/2058738419841482","article-title":"Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP\/PS1 transgenic mice","volume":"33","author":"Mana","year":"2019","journal-title":"Int. J. Immunopathol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib224","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13293-020-00357-w","article-title":"Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke","volume":"12","author":"Manwani","year":"2021","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.arr.2022.101592_bib225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.arr.2022.101592_bib226","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0166-2236(00)01548-4","article-title":"Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders","volume":"23","author":"Mattson","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib227","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12020-016-1146-8","article-title":"Glucocorticoid-induced osteoporosis: pathophysiological role of GH\/IGF-I and PTH\/VITAMIN D axes, treatment options and guidelines","volume":"54","author":"Mazziotti","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.arr.2022.101592_bib228","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fendo.2012.00088","article-title":"A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?","volume":"3","author":"McGonnell","year":"2012","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib229","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/gme.0b013e318258aad7","article-title":"Association of 11\u03b2-hydroxysteroid dehydrogenase type I expression and activity with estrogen receptor \u03b2 in adipose tissue from postmenopausal women","volume":"19","author":"McInnes","year":"2012","journal-title":"Menopause"},{"key":"10.1016\/j.arr.2022.101592_bib230","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1567205010666131212112529","article-title":"The novel multi-target iron chelator, M30 modulates HIF-1\u03b1-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP\/PS1 Alzheimer\u2019s disease mice","volume":"11","author":"Mechlovich","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101592_bib231","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1471-4159.2005.03155.x","article-title":"A biochemical and functional characterization of diet-induced brain insulin resistance","volume":"93","author":"Mielke","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101592_bib232","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1074\/jbc.M115.685578","article-title":"Transcriptional regulation of cystathionine-\u03b3-lyase in endothelial cells by NADPH oxidase 4-dependent signaling","volume":"291","author":"Mistry","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib233","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1016\/j.dsx.2016.01.021","article-title":"Shared links between type 2 diabetes mellitus and Alzheimer\u2019s disease: a review","volume":"10","author":"Mittal","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.arr.2022.101592_bib234","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bbrc.2018.05.015","article-title":"Cystathionine gamma lyase-H2S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading","volume":"501","author":"Mo","year":"2018","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101592_bib235","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.12.118","article-title":"A pilot study on the effect of lactoferrin on Alzheimer\u2019s disease pathological sequelae: impact of the p-Akt\/PTEN pathway","volume":"111","author":"Mohamed","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"Suppl 2","key":"10.1016\/j.arr.2022.101592_bib236","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1440-1746.2011.07023.x","article-title":"Alcohol, insulin resistance and the liver-brain axis","volume":"27","author":"de la Monte","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.arr.2022.101592_bib237","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02815155","article-title":"Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease","volume":"30","author":"de la Monte","year":"1997","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.arr.2022.101592_bib238","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"MacKenzie","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.arr.2022.101592_bib239","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.2337\/dc13-0229","article-title":"Increased risk of cognitive impairment in patients with diabetes is associated with metformin","volume":"36","author":"Moore","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arr.2022.101592_bib240","doi-asserted-by":"crossref","first-page":"17626","DOI":"10.1074\/jbc.M413343200","article-title":"Proteomic profiling of hepatic endoplasmic reticulum-associated proteins in an animal model of insulin resistance and metabolic dyslipidemia","volume":"280","author":"Morand","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib241","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/biom8040170","article-title":"Role of HIF-1alpha in alcohol-mediated multiple organ dysfunction","volume":"8","author":"Morris","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2022.101592_bib242","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.physbeh.2012.11.008","article-title":"Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF","volume":"109","author":"Moy","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.arr.2022.101592_bib243","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1159\/000017188","article-title":"Decreased plasma insulin-like growth factor-I level in familial Alzheimer\u2019s disease patients carrying the Swedish APP 670\/671 mutation","volume":"10","author":"Mustafa","year":"1999","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"10.1016\/j.arr.2022.101592_bib244","first-page":"69","article-title":"Interleukin-6 deficiency modifies the effect of high fat diet on myocardial expression of fatty acid transporters and myocardial lipids","author":"Mysliwiec","year":"2018","journal-title":"J. Physiol. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib245","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1074\/mcp.M114.040691","article-title":"O-GlcNAc modification of the runt-related transcription factor 2 (Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells","volume":"13","author":"Nagel","year":"2014","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.arr.2022.101592_bib246","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1254\/jjp.89.149","article-title":"Production of nitric oxide, but not prostacyclin, is reduced in klotho mice","volume":"89","author":"Nakamura","year":"2002","journal-title":"Jpn. J. Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib247","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cardiores.2004.07.011","article-title":"HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells","volume":"64","author":"Narumiya","year":"2004","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.arr.2022.101592_bib248","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00000542-197809000-00004","article-title":"Glucose transport across the rat blood-brain barrier during anesthesia","volume":"49","author":"Nemoto","year":"1978","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arr.2022.101592_bib249","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1465-9921-12-47","article-title":"A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression","volume":"12","author":"Ni","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.arr.2022.101592_bib250","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jnc.14034","article-title":"Exercise and BDNF reduce A\u03b2 production by enhancing \u03b1-secretase processing of APP","volume":"142","author":"Nigam","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101592_bib251","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/00365510500348153","article-title":"Plasma homocysteine and markers of bone metabolism in psychogeriatric patients","volume":"65","author":"Nilsson","year":"2005","journal-title":"Scand. J. Clin. Lab Invest."},{"key":"10.1016\/j.arr.2022.101592_bib252","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/FJC.0b013e3181624b44","article-title":"Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells","volume":"51","author":"Nishimoto-Hazuku","year":"2008","journal-title":"J. Cardiovasc Pharm."},{"key":"10.1016\/j.arr.2022.101592_bib253","first-page":"2319","article-title":"The Akt pathway in oncology therapy and beyond (Review)","volume":"53","author":"Nitulescu","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.arr.2022.101592_bib254","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2018.06.055","article-title":"Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1\/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-\u03baB pathway","volume":"503","author":"Noguchi","year":"2018","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101592_bib255","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13195-018-0371-1","article-title":"Multidomain Alzheimer Preventive Trial\/data Sharing Alzheimer (DSA) study group. Cross-sectional associations of plasma vitamin D with cerebral \u03b2-amyloid in older adults at risk of dementia","volume":"10","author":"Nourhashemi","year":"2018","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2022.101592_bib256","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2021.03.015","article-title":"Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-\u03b2 in cognitively unimpaired older adults","volume":"95","author":"Oberlin","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2022.101592_bib257","doi-asserted-by":"crossref","first-page":"19823","DOI":"10.1074\/jbc.RA118.002326","article-title":"Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake","volume":"293","author":"Ojelabi","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib258","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00441-014-1857-1","article-title":"Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice","volume":"357","author":"de Oliveira","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.arr.2022.101592_bib259","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/gps.4832","article-title":"Development of dementia in patients with femoral neck fracture who experience postoperative delirium-a three-year follow-up study","volume":"33","author":"Olofsson","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib260","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1038\/srep03754","article-title":"Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice","volume":"4","author":"Ong","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib261","first-page":"20","article-title":"Molecular mechanisms of hypothalamic insulin resistance","author":"Ono","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101592_bib262","first-page":"185","article-title":"Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area","volume":"153","author":"Orgogozo","year":"1997","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib263","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium-apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2022.101592_bib264","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: the Rotterdam study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101592_bib265","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s100380170077","article-title":"A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density","volume":"46","author":"Ota","year":"2001","journal-title":"J Hum Genet"},{"key":"10.1016\/j.arr.2022.101592_bib266","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/jgs.12887","article-title":"Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study","volume":"62","author":"Ozawa","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101592_bib267","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1210\/jc.2008-1301","article-title":"Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients","volume":"94","author":"Panicker","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib268","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/10715762.2018.1431626","article-title":"Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes","volume":"52","author":"Parsanathan","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.arr.2022.101592_bib269","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/YCO.0000000000000333","article-title":"A review of caffeine use as a risk or protective factor for women\u2019s health and pregnancy","volume":"30","author":"Peacock","year":"2017","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib270","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2017.09.033","article-title":"Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4","volume":"338","author":"Pearson-Leary","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2022.101592_bib271","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/01.hjh.0000133734.32125.c7","article-title":"Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension","volume":"22","author":"Pech\u00e1nov\u00e1","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1016\/j.arr.2022.101592_bib272","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.686506","article-title":"Amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice","volume":"13","author":"Peng","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib273","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1530\/EJE-09-0151","article-title":"Hormone therapy protects from diabetes: the Kuopio osteoporosis risk factor and prevention study","volume":"160","author":"Pentti","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib274","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/JAD-151205","article-title":"Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E \u025b4 carriers","volume":"53","author":"Perkins","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib275","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2174\/1567205015666171212094229","article-title":"Catechol-O-methyltransferase, cognition and Alzheimer\u2019s disease","volume":"15","author":"Perkovic","year":"2018","journal-title":"Curr. Alzheimer Res"},{"key":"10.1016\/j.arr.2022.101592_bib276","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tvjl.2004.01.026","article-title":"Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes","volume":"169","author":"Phillips","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.arr.2022.101592_bib277","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bone.2018.07.015","article-title":"Differential effects of high-fat diet and exercise training on bone and energy metabolism","volume":"116","author":"Picke","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib278","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.bbadis.2018.10.037","article-title":"Diminished O-GlcNAcylation in Alzheimer\u2019s disease is strongly correlated with mitochondrial anomalies","volume":"1865","author":"Pinho","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101592_bib279","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3174\/ajnr.A4322","article-title":"White matter alterations in the brains of patients with active, remitted, and cured cushing syndrome: a DTI study","volume":"36","author":"Pires","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.arr.2022.101592_bib280","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2213-8587(16)00086-3","article-title":"Complications of Cushing's syndrome: state of the art","volume":"4","author":"Pivonello","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib281","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nn.2893","article-title":"Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling","volume":"14","author":"Pratt","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib282","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.jada.2008.09.013","article-title":"Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer\u2019s disease","volume":"108","author":"Presse","year":"2008","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.arr.2022.101592_bib283","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jsbmb.2017.03.005","article-title":"GPER modulators: opportunity Nox on the heels of a class Akt","volume":"176","author":"Prossnitz","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib284","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s12640-019-0003-y","article-title":"The role of PI3K\/Akt and ERK in neurodegenerative disorders","volume":"35","author":"Rai","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2022.101592_bib285","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neurobiolaging.2004.02.011","article-title":"Association between the interleukin-1alpha gene and Alzheimer\u2019s disease: a meta-analysis","volume":"25","author":"Rainero","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101592_bib286","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13058-018-1061-4","article-title":"Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study","volume":"20","author":"Ramin","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.arr.2022.101592_bib287","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000495234","article-title":"Vitamin K supplementation modulates bone metabolism and ultra-structure of ovariectomized mice","volume":"51","author":"Rangel","year":"2018","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.arr.2022.101592_bib288","doi-asserted-by":"crossref","first-page":"11940","DOI":"10.1038\/s41598-017-11608-z","article-title":"A novel H2S-releasing amino-bisphosphonate which combines bone anti-catabolic and anabolic functions","volume":"7","author":"Rapposelli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib289","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3233\/JAD-122407","article-title":"Association between interleukin 6 gene haplotype and Alzheimer\u2019s disease: a Brazilian case-control study","volume":"36","author":"Rasmussen","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib290","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.canlet.2007.07.021","article-title":"Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines","volume":"257","author":"Rastogi","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.arr.2022.101592_bib291","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3390\/nu10091175","article-title":"Association between vitamin D deficiency and single nucleotide polymorphisms in the vitamin D receptor and GC genes and analysis of their distribution in mexican postmenopausal women","volume":"10","author":"Rivera-Paredez","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2022.101592_bib292","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00198-020-05497-8","article-title":"Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?","volume":"31","author":"Rozenberg","year":"2020","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.arr.2022.101592_bib293","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/jbmr.410","article-title":"Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans","volume":"26","author":"Rufo","year":"2011","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.arr.2022.101592_bib294","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00198-016-3784-3","article-title":"Early post-surgical cognitive dysfunction is a risk factor for mortality among hip fracture hospitalized older persons","volume":"28","author":"Ruggiero","year":"2017","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.arr.2022.101592_bib295","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12704","article-title":"Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury-induced ferroptosis","volume":"70","author":"Rui","year":"2021","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.arr.2022.101592_bib296","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0003-9969(81)90035-2","article-title":"Osteoporotic effect of a high-carbohydrate diet (Keyes 2000) in golden hamsters","volume":"26","author":"Saffar","year":"1981","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib297","doi-asserted-by":"crossref","first-page":"C90","DOI":"10.1152\/ajpcell.00387.2012","article-title":"Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation","volume":"305","author":"Salas","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.arr.2022.101592_bib298","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/1567205015666171227154636","article-title":"Vitamin D increases A\u03b21-40 plasma levels and protects lymphocytes from oxidative death in mild cognitive impairment patients","volume":"15","author":"SanMartin","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101592_bib299","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10522-017-9732-6","article-title":"Exercise and bone health across the lifespan","volume":"18","author":"Santos","year":"2017","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2022.101592_bib300","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bone.2014.12.012","article-title":"Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice","volume":"73","author":"Sato","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib301","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.18632\/aging.203330","article-title":"beta-amyloid monomers drive up neuronal aerobic glycolysis in response to energy stressors","volume":"13","author":"Santangelo","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.arr.2022.101592_bib302","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tins.2004.12.005","article-title":"Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue?","volume":"28","author":"Scharfman","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib303","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10549-015-3661-3","article-title":"The impact of treatment compliance on fracture risk in women with breast cancer treated with aromatase inhibitors in the United Kingdom","volume":"155","author":"Schmidt","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.arr.2022.101592_bib304","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/154099904323087123","article-title":"Osteoporosis in women with disabilities","volume":"13","author":"Schrager","year":"2004","journal-title":"J. Women\u2019s. Health"},{"key":"10.1016\/j.arr.2022.101592_bib305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.03.012","article-title":"Paradoxical effect of testosterone supplementation therapy on cardiac ischemia\/reperfusion injury in aged rats","volume":"191","author":"Seara","year":"2019","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.arr.2022.101592_bib306","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1073\/pnas.1916895117","article-title":"Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer\u2019s disease","volume":"117","author":"Sen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib307","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12883-016-0765-2","article-title":"Inverse relationship between Alzheimer\u2019s disease and cancer, and other factors contributing to Alzheimer\u2019s disease: a systematic review","volume":"16","author":"Shafi","year":"2016","journal-title":"BMC Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib308","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1038\/srep14500","article-title":"O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling","volume":"5","author":"Shi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib309","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/01.CIR.0000139854.74847.99","article-title":"Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse","volume":"110","author":"Shimada","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2022.101592_bib310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11010-015-2391-5","article-title":"Association of estrogen receptor \u03b2 and estrogen-related receptor \u03b1 gene polymorphisms with bone mineral density in postmenopausal women","volume":"405","author":"Shoukry","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.arr.2022.101592_bib311","doi-asserted-by":"crossref","first-page":"E293","DOI":"10.1210\/jc.2013-1418","article-title":"Genetic polymorphisms in 11\u03b2-hydroxysteroid dehydrogenase type 1 correlate with the postdexamethasone cortisol levels and bone mineral density in patients evaluated for osteoporosis","volume":"99","author":"Siggelkow","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101592_bib312","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.expneurol.2016.01.007","article-title":"The role of endoplasmic reticulum stress in hippocampal insulin resistance","volume":"277","author":"Sims-Robinson","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib313","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1089\/ars.2012.4931","article-title":"Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities","volume":"20","author":"Singh","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2022.101592_bib314","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00223-002-2069-3","article-title":"Interaction of nutritional calcium and HRT in prevention of postmenopausal bone loss: a prospective study","volume":"72","author":"Sirola","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.arr.2022.101592_bib315","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/er.2002-0017","article-title":"Molecular endocrinology and physiology of the aging central nervous system","volume":"26","author":"Smith","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.arr.2022.101592_bib316","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1210\/en.2015-1395","article-title":"Cognitive and disease-modifying effects of 11\u03b2-hydroxysteroid dehydrogenase Type 1 inhibition in male Tg2576 mice, a model of Alzheimer\u2019s disease","volume":"156","author":"Sooy","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib317","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1677\/joe.1.05723","article-title":"Rosiglitazone impacts negatively on bone by promoting osteoblast\/osteocyte apoptosis","volume":"183","author":"Soroc\u00e9anu","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.arr.2022.101592_bib318","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-2005-7107","article-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer\u2019s disease--is this type 3 diabetes?","volume":"7","author":"Steen","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib319","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1523\/JNEUROSCI.4386-03.2004","article-title":"Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer\u2019s-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability","volume":"24","author":"Stutzmann","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib320","first-page":"208","article-title":"Vitamin D3, vitamin K2, andwarfarin regulate bone metabolism in human paranasal sinus bones","volume":"45","author":"Sugimoto","year":"2007","journal-title":"Rhinology"},{"key":"10.1016\/j.arr.2022.101592_bib321","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuroscience.2011.09.054","article-title":"Calbindin-D28K inhibits apoptosis in dopaminergic neurons by activation of the PI3-kinase-Akt signaling pathway","volume":"199","author":"Sun","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101592_bib322","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/molecules23040835","article-title":"Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases","volume":"23","author":"Sundar Dhilip Kumar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2022.101592_bib323","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3233\/JAD-160841","article-title":"Glucose transporters in brain: in health and in Alzheimer\u2019s disease","volume":"55","author":"Szablewski","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib324","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jagp.2016.05.008","article-title":"Predictive factors for verbal memory performance over decades of aging: data from the women\u2019s healthy ageing project","volume":"24","author":"Szoeke","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib325","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1074\/jbc.M115.693598","article-title":"Regulation of ligand and shear stress-induced insulin-like growth factor 1 (IGF1) signaling by the integrin pathway","volume":"291","author":"Tahimic","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib326","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1139\/bcb-2016-0039","article-title":"Role of CXC chemokine receptor type 4 as a lactoferrin receptor","volume":"95","author":"Takayama","year":"2017","journal-title":"Biochem Cell Biol."},{"key":"10.1016\/j.arr.2022.101592_bib327","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.expneurol.2018.09.002","article-title":"ER\u03b1 and\/or ER\u03b2 activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice","volume":"311","author":"Tang","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101592_bib328","article-title":"Deletion of rptor in preosteoblasts reveals a role for the mammalian target of rapamycin complex 1 (mTORC1) complex in dietary-induced changes to bone mass and glucose homeostasis in female mice","volume":"5","author":"Tangseefa","year":"2021","journal-title":"JBMR"},{"key":"10.1016\/j.arr.2022.101592_bib329","doi-asserted-by":"crossref","first-page":"16711","DOI":"10.1073\/pnas.0407335101","article-title":"Postmenopausal osteoporosis, T cells, and immune dysfunction","volume":"101","author":"Teitelbaum","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2022.101592_bib330","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02257671","article-title":"Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type","volume":"5","author":"Tham","year":"1993","journal-title":"J. Neural Transm. Park Dis. Dement Sect."},{"key":"10.1016\/j.arr.2022.101592_bib331","article-title":"Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK","volume":"9","author":"Thompson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101592_bib332","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1210\/en.2016-1864","article-title":"Nitric oxide-mediated regulation of GLUT by T3 and follicle-stimulating hormone in rat granulosa cells","volume":"158","author":"Tian","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib333","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/1873-3468.13613","article-title":"Soluble Klotho regulates bone differentiation by upregulating expression of the transcription factor EGR-1","volume":"594","author":"Toan","year":"2019","journal-title":"FEBS Lett. Sept."},{"key":"10.1016\/j.arr.2022.101592_bib334","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1210\/endo.138.3.4982","article-title":"Characterization of a low affinity thyroid hormone receptor binding site within the rat GLUT4 gene promoter","volume":"138","author":"Torrance","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib335","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-018-0133-9","article-title":"Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome","volume":"7","author":"Tramutola","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2022.101592_bib336","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1016\/j.bbadis.2018.07.017","article-title":"Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer\u2019s disease","volume":"1864","author":"Tramutola","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101592_bib337","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1055\/s-0038-1657783","article-title":"New anticoagulant agents: incidence of adverse drug reactions and new signals thereof","volume":"45","author":"Trece\u00f1o-Lobato","year":"2019","journal-title":"Semin Thromb. Hemost."},{"key":"10.1016\/j.arr.2022.101592_bib338","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/antiox10071049","article-title":"Characterization of the inducible and slow-releasing hydrogen sulfide and persulfide donor P*: insights into hydrogen sulfide signaling","volume":"10","author":"Trummer","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2022.101592_bib339","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41380-020-0762-0","article-title":"Amyloidogenic processing of Alzheimer\u2019s disease beta-amyloid precursor protein induces cellular iron retention","volume":"25","author":"Tsatsanis","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib340","first-page":"35","article-title":"The influence of thyroid disorders on bone density and biochemical markers of bone metabolism","author":"Tsevis","year":"2018","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"10.1016\/j.arr.2022.101592_bib341","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/schbul\/sbz119","article-title":"Normalizing the abnormal: do antipsychotic drugs push the cortex into an unsustainable metabolic envelope?","volume":"46","author":"Turkheimer","year":"2019","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.arr.2022.101592_bib342","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neures.2010.10.004","article-title":"Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer\u2019s disease","volume":"69","author":"Um","year":"2011","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101592_bib343","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10549-017-4627-4","article-title":"Cognitive sequelae of endocrine therapy in women treated for breast cancer: a meta-analysis","volume":"168","author":"Underwood","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.arr.2022.101592_bib344","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bone.2018.04.025","article-title":"The osteoblast: Linking glucocorticoid-induced osteoporosis and hyperglycaemia? A post-hoc analysis of a randomised clinical trial","volume":"112","author":"van Bommel","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib345","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000494113","article-title":"Mechanisms of hydrogen sulfide against the progression of severe Alzheimer\u2019s disease in transgenic mice at different ages","volume":"103","author":"Vandini","year":"2019","journal-title":"Pharmacology"},{"key":"10.1016\/j.arr.2022.101592_bib346","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/cdd.2015.1","article-title":"The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration","volume":"22","author":"Varadarajan","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101592_bib347","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3233\/JAD-170288","article-title":"Delirium severity post-surgery and its relationship with long-term cognitive decline in a cohort of patients without dementia","volume":"61","author":"Vasunilashorn","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib348","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.abb.2018.04.020","article-title":"Inhibition of PP2A by hesperetin may contribute to Akt and ERK1\/2 activation status in cortical neurons","volume":"650","author":"Vauzour","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.arr.2022.101592_bib349","doi-asserted-by":"crossref","first-page":"10874","DOI":"10.1523\/JNEUROSCI.2350-05.2005","article-title":"Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer\u2019s disease pathogenesis","volume":"25","author":"Velliquette","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib350","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/250462","article-title":"Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency","volume":"2013","author":"Ventura","year":"2013","journal-title":"Biomed. Res Int."},{"key":"10.1016\/j.arr.2022.101592_bib351","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/acr.23735","article-title":"Statin use and knee osteoarthritis outcomes: a longitudinal cohort study","volume":"71","author":"Veronese","year":"2018","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.arr.2022.101592_bib352","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0735-1097(03)00156-6","article-title":"Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women","volume":"41","author":"Vongpatanasin","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2022.101592_bib353","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/derm.24494","article-title":"Sunlight and vitamin D: a global perspective for health","volume":"5","author":"Wacker","year":"2013","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.arr.2022.101592_bib354","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.3390\/ijms19082325","article-title":"mTORC inhibitors as broad-spectrum therapeutics for age-related diseases","volume":"19","author":"Walters","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101592_bib355","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2015.05.020","article-title":"Simvastatin prevents \u03b2-amyloid (25-35)-impaired neurogenesis in hippocampal dentate gyrus through \u03b17nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate","volume":"97","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2022.101592_bib356","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1085259","article-title":"Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions","volume":"300","author":"Wang","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101592_bib357","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12871-019-0808-5","article-title":"Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K\/Akt\/mTOR pathway","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Anesth."},{"key":"10.1016\/j.arr.2022.101592_bib358","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2147\/DDDT.S188636","article-title":"Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K\/AKT\/GSK-3\u03b2 pathway","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.arr.2022.101592_bib359","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.yexcr.2018.08.033","article-title":"NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK-3beta via calcineurin in cultured immature hippocampal neurons","volume":"371","author":"Wang","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.arr.2022.101592_bib360","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2147\/DDDT.S141675","article-title":"Metformin: a review of its potential indications","volume":"11","author":"Wang","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.arr.2022.101592_bib361","article-title":"Mechanism of dexmedetomidine regulating osteogenesis-angiogenesis coupling through the miR-361-5p\/VEGFA axis in postmenopausal osteoporosis","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101592_bib362","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.metabol.2018.02.013","article-title":"Impaired brain energy gain upon a glucose load in obesity","volume":"85","author":"Wardzinski","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.arr.2022.101592_bib363","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11910-012-0264-9","article-title":"Review chemotherapy-related cognitive dysfunction","volume":"12","author":"Wefel","year":"2012","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib364","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pnpbp.2013.05.009","article-title":"Dual effects of neuroprotection and neurotoxicity by general anesthetics: Role of intracellular calcium homeostasis","volume":"47","author":"Wei","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.arr.2022.101592_bib365","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/2211-5463.13203","article-title":"Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt\/Nrf2\/HO-1 signaling pathway","volume":"11","author":"Wei","year":"2021","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.arr.2022.101592_bib366","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1210\/en.2008-1355","article-title":"Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress","volume":"150","author":"Weiser","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2022.101592_bib367","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2165\/00007256-200434120-00001","article-title":"Are cardiovascular disease and osteoporosis directly linked?","volume":"34","author":"Whitney","year":"2004","journal-title":"Sports Med."},{"key":"10.1016\/j.arr.2022.101592_bib368","first-page":"E397","article-title":"Acute exercise attenuates age-associated resistance to insulin-like growth factor I.","volume":"272","author":"Willis","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2022.101592_bib369","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1212\/WNL.35.7.957","article-title":"Alzheimer's disease in Down's syndrome: clinicopathologic studies","volume":"35","author":"Wisniewski","year":"1985","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101592_bib370","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1227\/NEU.0b013e31820c06b9","article-title":"Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury","volume":"68","author":"Wu","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.arr.2022.101592_bib371","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2018.12.019","article-title":"Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis","volume":"121","author":"Wu","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib372","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.12659\/MSM.894347","article-title":"Advanced oxidation protein products as a novel marker of oxidative stress in postmenopausal osteoporosis","volume":"21","author":"Wu","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.arr.2022.101592_bib373","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/jbmr.1954","article-title":"Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine","volume":"28","author":"Xia","year":"2013","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.arr.2022.101592_bib374","first-page":"7789","article-title":"MicroRNA 148a inhibition protects against ovariectomy induced osteoporosis through PI3K\/AKT signaling by estrogen receptor \u03b1","volume":"17","author":"Xiao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.arr.2022.101592_bib375","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.3390\/molecules19045119","article-title":"Catechins and procyanidins of Ginkgo biloba show potent activities towards the inhibition of \u03b2-amyloid peptide aggregation and destabilization of preformed fibrils","volume":"19","author":"Xie","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2022.101592_bib376","doi-asserted-by":"crossref","first-page":"20270","DOI":"10.1074\/jbc.M117.796367","article-title":"1\u03b1,25-Dihydroxyvitamin D3 promotes bone formation by promoting nuclear exclusion of the FoxO1 transcription factor in diabetic mice","volume":"292","author":"Xiong","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib377","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/ijerph14070787","article-title":"Airborne PM2.5-induced hepatic insulin resistance by Nrf2\/JNK-mediated signaling pathway","volume":"14","author":"Xu","year":"2017","journal-title":"Int. J. Environ. Res Public Health"},{"key":"10.1016\/j.arr.2022.101592_bib378","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10654-017-0225-3","article-title":"Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies","volume":"32","author":"Xu","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.arr.2022.101592_bib379","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1532-5415.1999.tb05196.x","article-title":"Association between bone mineral density and cognitive decline in older women","volume":"47","author":"Yaffe","year":"1999","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101592_bib380","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00109-004-0578-4","article-title":"Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women","volume":"83","author":"Yamada","year":"2005","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.arr.2022.101592_bib381","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/glia.22974","article-title":"Simvastatin and atorvastatin facilitates amyloid \u03b2-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK\/Erk1\/2 pathways","volume":"64","author":"Yamamoto","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.arr.2022.101592_bib382","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.201901550R","article-title":"Amyloid \u03b2 peptide promotes bone formation by regulating Wnt\/ \u03b2-catenin signaling and the OPG\/RANKL\/RANK system","volume":"34","author":"Yang","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101592_bib383","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroscience.2018.09.024","article-title":"HIF-1 alpha repression of PTEN transcription mediates protective effects of BMSCs on neurons during hypoxia","volume":"392","author":"Yang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101592_bib384","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1074\/jbc.M411871200","article-title":"S-nitrosylation-dependent inactivation of Akt\/protein kinase B in insulin resistance","volume":"280","author":"Yasukawa","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101592_bib385","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnagi.2012.00024","article-title":"Local amplification of glucocorticoids in the aging brain and impaired spatial memory","volume":"4","author":"Yau","year":"2012","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101592_bib386","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.bbagen.2006.12.009","article-title":"Inhibition of PTEN and activation of Akt by menadione","volume":"1770","author":"Yoshikawa","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101592_bib387","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2020.101803","article-title":"The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study","volume":"108","author":"Youssef","year":"2020","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.arr.2022.101592_bib388","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-181249","article-title":"The potential influence of bone-derived modulators on the progression of Alzheimer\u2019s disease","volume":"69","author":"Yuan","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101592_bib389","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1326-9-42","article-title":"Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau\/APP mutant mice","volume":"9","author":"Yuzwa","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2022.101592_bib390","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.3390\/nu11102525","article-title":"Vitamins D and E stimulate the PI3K-AKT signalling pathway in insulin-resistant SK-N-SH neuronal cells","volume":"11","author":"Zaulkffali","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2022.101592_bib391","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neures.2019.04.002","article-title":"Repetitive transcranial magnetic stimulation ameliorates recognition memory impairment induced by hindlimb unloading in mice associated with BDNF\/TrkB signaling","volume":"153","author":"Zhai","year":"2019","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101592_bib392","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuint.2010.11.010","article-title":"Hydrogen sulfide reduces mRNA and protein levels of beta-site amyloid precursor protein cleaving enzyme 1 in PC12 cells","volume":"58","author":"Zhang","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2022.101592_bib393","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuint.2015.12.005","article-title":"Tissue-specific insulin signaling in the regulation of metabolism and aging","volume":"92","author":"Zhang","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2022.101592_bib394","first-page":"20200810","article-title":"Effect of metformin on (18)F-fluorodeoxyglucose uptake and positron emission tomographic imaging","volume":"Oct 27","author":"Zhang","year":"2021","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.arr.2022.101592_bib395","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/aje\/154.9.795","article-title":"Bone mineral density and verbal memory impairment: third National Health and Nutrition Examination Survey","volume":"154","author":"Zhang","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.arr.2022.101592_bib396","doi-asserted-by":"crossref","first-page":"647","DOI":"10.21037\/atm-20-3768","article-title":"Beta carotene protects H9c2 cardiomyocytes from advanced glycation end product-induced endoplasmic reticulum stress, apoptosis, and autophagy via the PI3K\/Akt\/mTOR signaling pathway","volume":"8","author":"Zhao","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.arr.2022.101592_bib397","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1016\/j.bbadis.2018.07.014","article-title":"Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis","volume":"1864","author":"Zheng","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101592_bib398","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13205-021-02738-3","article-title":"Role of insulin receptor substance-1 modulating PI3K\/Akt insulin signaling pathway in Alzheimer\u2019s disease","volume":"11","author":"Zheng","year":"2021","journal-title":"3 Biotech."},{"key":"10.1016\/j.arr.2022.101592_bib399","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2174\/1567205011666140812115818","article-title":"Bone loss and osteoporosis are associated with conversion from mild cognitive impairment to Alzheimer\u2019s disease","volume":"11","author":"Zhou","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101592_bib400","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcb.1096","article-title":"Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice","volume":"36","author":"Zhou","year":"2001","journal-title":"J. Cell Biochem Suppl."},{"key":"10.1016\/j.arr.2022.101592_bib401","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11011-018-0328-x","article-title":"Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress","volume":"34","author":"Zhu","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2022.101592_bib402","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2015.05.046","article-title":"New insights into the biology of osteocalcin","volume":"82","author":"Zoch","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.arr.2022.101592_bib403","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-010-0634-z","article-title":"Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I","volume":"348","author":"Zoidis","year":"2011","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.arr.2022.101592_bib404","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1515\/cclm-2011-0589","article-title":"Interleukin-1\u03b1 gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people","volume":"50","author":"Zupan","year":"2012","journal-title":"Clin. Chem. Lab Med."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722000344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722000344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:00:55Z","timestamp":1761591655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163722000344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":404,"alternative-id":["S1568163722000344"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101592","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comorbidity of osteoporosis and Alzheimer\u2019s disease: Is `AKT `-ing on cellular glucose uptake the missing link?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101592"}}