{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:10:01Z","timestamp":1792091401468,"version":"4.4.0"},"reference-count":255,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.04442"],"award-info":[{"award-number":["2020.04442"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-029369"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029369"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.arr.2022.101612","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T17:45:04Z","timestamp":1648316704000},"page":"101612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"special_numbering":"C","title":["Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer\u2019s disease: Past, present and future"],"prefix":"10.1016","volume":"77","author":[{"given":"Filipa","family":"Gouveia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Camins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Ettcheto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Bicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00edlcar","family":"Falc\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Teresa","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fortuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101612_bib1","first-page":"329","article-title":"A comparative study on the memory-enhancing actions of oral renin-angiotensin system altering drugs in scopolamine-treated mice","volume":"34","author":"Ababei","year":"2019","journal-title":"Curr. Top. Res."},{"key":"10.1016\/j.arr.2022.101612_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.15171\/apb.2016.067","article-title":"Captopril and valsartan may improve cognitive function through potentiation of the brain antioxidant defense system and attenuation of oxidative \/ nitrosative damage in STZ-induced dementia in rat","volume":"6","author":"Abbassi","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.arr.2022.101612_bib3","first-page":"1","article-title":"Inhibition of ACE retards tau hyperphosphorylation and signs of neuronal degeneration in aged rats subjected to chronic mild stress","volume":"2015","author":"Abdalla","year":"2015","journal-title":"Hindawi Publ. Corp."},{"key":"10.1016\/j.arr.2022.101612_bib4","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer \u2019 s disease","volume":"14","author":"Abdalla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101612_bib5","doi-asserted-by":"crossref","first-page":"39721","DOI":"10.1074\/jbc.M105253200","article-title":"The Angiotensin II AT 2 receptor is an AT 1 receptor antagonist","volume":"276","author":"Abdalla","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: an update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.arr.2022.101612_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1248\/bpb.27.765","article-title":"Angiotensin IV and an aminopeptidase","volume":"27","author":"Albiston","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.arr.2022.101612_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1043-2760(02)00037-1","article-title":"AT 4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement","volume":"14","author":"Albiston","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.arr.2022.101612_bib9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/jpet.112.197483","article-title":"AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator","volume":"344","author":"Alhusban","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00210-016-1234-6","article-title":"Tempol and perindopril protect against lipopolysaccharide- induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress","volume":"389","author":"Ali","year":"2016","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jalz.2016.03.001","article-title":"2016 Alzheimer \u2019 s disease facts and figures","volume":"12","author":"Alzheimer\u2019s Association Report","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"10.1016\/j.arr.2022.101612_bib12","unstructured":"Alzheimer\u2019s Society, n.d. Alzheimer\u2019s disease [WWW Document]. https:\/\/www.alzheimers.org.uk\/about-dementia\/types-dementia\/alzheimers-disease."},{"key":"10.1016\/j.arr.2022.101612_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(10)70250-7","article-title":"Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies","volume":"10","author":"Anderson","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2022.101612_bib14","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1111\/j.1471-4159.1982.tb07930.x","article-title":"Angiotensin converting enzyme in Alzheimer \u2019 s disease: increased activity in caudate nucleus and cortical areas","volume":"38","author":"Arregui","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2018.00116","article-title":"Microglial activation is modulated by captopril: in vitro and in vivo studies","volume":"12","author":"Asraf","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib16","doi-asserted-by":"crossref","unstructured":"Association, A., 2019. 2019 Alzheimer\u2019s Disease Facts and Figures 15, 321\u2013387.","DOI":"10.1016\/j.jalz.2019.01.010"},{"key":"10.1016\/j.arr.2022.101612_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pbb.2015.08.007","article-title":"Pharmacology, biochemistry and behavior telmisartan mediates anti-in fl ammatory and not cognitive function through PPAR- \u03b3 agonism via SARM and MyD88 signaling","volume":"137","author":"Balaji","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.arr.2022.101612_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0006-8993(90)90294-L","article-title":"Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition","volume":"507","author":"Barnes","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0006-8993(89)90095-4","article-title":"Angiotensin II inhibits the release of [ 3H] acetylcholine from rat entorhinal cortex in vitro","volume":"491","author":"Barnes","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0206705","article-title":"The association of multiple anti-hypertensive medication classes with Alzheimer \u2019 s disease incidence across sex, race, and ethnicity","volume":"13","author":"Barthold","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101612_bib21","first-page":"408","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"JSTOR"},{"key":"10.1016\/j.arr.2022.101612_bib22","first-page":"1","article-title":"Neuroprotective mechanisms of the ACE2-Angiotensin-(1-7)-mas axis in stroke","volume":"17","author":"Bennion","year":"2016","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.arr.2022.101612_bib23","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1007\/s12035-015-9584-5","article-title":"Angiotensin receptor blockade modulates NF \u03ba B and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition","volume":"53","author":"Bhat","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib24","article-title":"Angiotensin receptor blockade modulates NF \u03ba B and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition","author":"Bhat","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib25","article-title":"Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt \/ \u03b2 -Catenin signaling in hypertension","author":"Bhat","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/ajpheart.00247.2015","article-title":"Cross talk between AT 1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus","volume":"310","author":"Biancardi","year":"2016","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"10.1016\/j.arr.2022.101612_bib27","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.25049","article-title":"Dendritic spines provide cognitive resilience against Alzheimer\u2019s disease","volume":"82","author":"Boros","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2022.101612_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2017.01.006","article-title":"Indispensable role of the voltage-gated calcium channels in the procognitive effects of angiotensin IV","author":"Braszko","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.arr.2022.101612_bib29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3317\/jraas.2006.027","article-title":"Cognitive effects attributed to Angiotensin II may result from its conversion to Angiotensin IV","volume":"7","author":"Braszko","year":"2006","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.arr.2022.101612_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-012-2829-3","article-title":"Candesartan prevents impairment of recall caused by repeated stress in rats","volume":"225","author":"Braszko","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.arr.2022.101612_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3233\/JAD-2008-13310","article-title":"Haplotypes across ACE and the risk of Alzheimer \u2019 s disease: the three-city study","volume":"13","author":"Braundet","year":"2008","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1755-5949.2008.00057.x","article-title":"Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy","volume":"14","author":"Bundel","year":"2008","journal-title":"Neurosci. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nlm.2009.02.004","article-title":"Neurobiology of learning and memory Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: effects on hippocampal glucose levels and blood flow","volume":"92","author":"Bundel","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2022.101612_bib34","first-page":"1","article-title":"Neuroinflammation in Alzheimer \u2019 s disease: current evidence and future directions","author":"Calsolaro","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"10.1016\/j.arr.2022.101612_bib35","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41374-019-0231-z","article-title":"The amyloid cascade and Alzheimer \u2019 s disease therapeutics: theory versus observation","volume":"99","author":"Castellani","year":"2019","journal-title":"Lab. Investig."},{"key":"10.1016\/j.arr.2022.101612_bib36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41374-019-0231-z","article-title":"The amyloid cascade and Alzheimer \u2019 s disease therapeutics: theory versus observation","volume":"99","author":"Castellani","year":"2019","journal-title":"Lab. Investig."},{"key":"10.1016\/j.arr.2022.101612_bib37","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s00018-004-4246-1","article-title":"The angiotensin IV \/ AT 4 receptor","volume":"61","author":"Chai","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2022.101612_bib38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1161\/01.HYP.31.1.362","article-title":"Metabolism of Angiotensin-(1\u22127) by Angiotensin-converting enzyme","volume":"31","author":"Chappell","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2017.01.027","article-title":"Angiotensin- ( 1-7) administration attenuates Alzheimer \u2019 s disease-like receptor activation","author":"Chen","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101612_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.12779\/dnd.2017.16.3.64","article-title":"Candesartan restores the amyloid beta-inhibited proliferation of neural stem cells by activating the phosphatidylinositol 3-kinase pathway","volume":"16","author":"Choi","year":"2017","journal-title":"Dement. Neurocogn. Disord."},{"key":"10.1016\/j.arr.2022.101612_bib41","first-page":"1","article-title":"Angiotensin-converting enzyme insertion \/ deletion polymorphism and the longitudinal progression of Alzheimer \u2019 s disease","author":"Chou","year":"2016","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.arr.2022.101612_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2015.09.004","article-title":"Angiotensin IV possibly acts through PKMzeta in the hippocampus to regulate cognitive memory in rats","author":"Chow","year":"2015","journal-title":"Neuropeptides"},{"key":"10.1016\/j.arr.2022.101612_bib43","first-page":"228","article-title":"Alzheimer \u2019 s disease: early diagnosis and treatment","volume":"18","author":"Chu","year":"2012","journal-title":"Hong Kong Med. J."},{"key":"10.1016\/j.arr.2022.101612_bib44","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2019.10.062","article-title":"Alzheimer \u2019 s disease and vascular aging","volume":"75","author":"Cortes-canteli","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2022.101612_bib45","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1007\/s12035-017-0805-y","article-title":"Paracrine and intracrine Angiotensin 1-7 \/ Mas receptor axis in the substantia nigra of rodents, monkeys, and humans","volume":"55","author":"Costa-besada","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib46","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4149\/BLL_2018_039","article-title":"Alternative hypotheses related to Alzheimer \u2019 s disease","volume":"119","author":"Cubinkova","year":"2018","journal-title":"Bratisl. Med. J."},{"key":"10.1016\/j.arr.2022.101612_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.684874","article-title":"The altered anatomical distribution of ACE 2 in the brain with Alzheimer\u2019s disease pathology","volume":"9","author":"Cui","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2022.101612_bib48","first-page":"1","article-title":"Alzheimer \u2019 s disease drug development pipeline: 2020","author":"Cummings","year":"2020","journal-title":"Transl. Res. Clin. Interv."},{"key":"10.1016\/j.arr.2022.101612_bib49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/rej.2009.0944","article-title":"Protective effects of intranasal losartan in the APP \/ PS1 transgenic mouse model of Alzheimer disease","volume":"13","author":"Danielyan","year":"2010","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.arr.2022.101612_bib50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer \u2019 s disease, vascular dementia, and other dementias","volume":"26","author":"Davies","year":"2014","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer \u2019 s disease, vascular dementia, and other dementias","volume":"26","author":"Davies","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib52","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.neuroscience.2005.10.051","article-title":"At 4 receptor activation increases intracellular calcium influx and induces a non- n -methyl- D -aspartate dependent form of long-term potentiation","volume":"137","author":"Davis","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101612_bib53","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1097\/00029330-200811020-00019","article-title":"Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease","volume":"121","author":"De-ren","year":"2008","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.arr.2022.101612_bib54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0006-8993(91)90812-A","article-title":"Angiotensin II blocks hippocampal long-term potentiation","volume":"567","author":"Denny","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib55","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s12035-020-02236-2","article-title":"Pathophysiological clues to how the emergent SARS-CoV-2 can potentially increase the susceptibility to neurodegeneration","volume":"58","author":"Dolatshahi","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/NEN.0b013e31816a0dc8","article-title":"Apolipoprotein E, amyloid-\u03b2, and blood-brain barrier permeability in Alzheimer disease","volume":"67","author":"Donahue","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101612_bib57","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1096\/fj.11-182873","article-title":"Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer \u2019 s disease","volume":"25","author":"Dong","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101612_bib58","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s13311-019-00723-6","article-title":"Intranasal losartan decreases perivascular beta amyloid, inflammation, and the decline of neurogenesis in hypertensive rats","volume":"16","author":"Drews","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2022.101612_bib59","unstructured":"Drug Bank [WWW Document], n.d. \u3008https:\/\/go.drugbank.com\/\u3009. (Accessed 1.11.21)."},{"key":"10.1016\/j.arr.2022.101612_bib60","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.gene.2019.05.030","article-title":"Genetic factors associated with the predisposition to late onset Alzheimer \u2019 s disease","volume":"707","author":"Durmaz","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.arr.2022.101612_bib61","unstructured":"Duthey, B., 2013. Background Paper 6. 11 Alzheimer disease and other dementias."},{"key":"10.1016\/j.arr.2022.101612_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-015-0167-5","article-title":"An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer \u2019 s disease","volume":"8","author":"Elkahloun","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib63","article-title":"ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer \u2019 s disease","author":"Evans","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2022.101612_bib64","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2174\/1570159X15666170720095240","article-title":"Microglia and astrocytes in Alzheimer \u2019 s disease: implications for therapy","volume":"16","author":"Fakhoury","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib65","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1471-4159.2007.04659.x","article-title":"Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neuronse","volume":"102","author":"Fernando","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib66","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00228-003-0717-9","article-title":"Effects of valsartan compared with enalapril on blood pressure and cognitive function in elderly patients with essential hypertension","volume":"59","author":"Fogari","year":"2004","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib67","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.jhh.1001613","article-title":"Influence of losartan and atenolol on memory function in very elderly hypertensive patients","volume":"17","author":"Fogari","year":"2003","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib68","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal tranduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2022.101612_bib69","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","article-title":"The cholinergic hypothesis of Alzheimer \u2019 s disease: a review of progress","volume":"66","author":"Francis","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2022.101612_bib70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12031-010-9371-8","article-title":"Expression of astrocytic type 2 angiotensin receptor in central nervous system inflammation correlates with blood \u2013 brain barrier breakdown","volume":"42","author":"F\u00fcchtbauer","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2011.00017","article-title":"Angiotensin II, a neuropeptide at the frontier between endocrinology and neuroscience: is there a link between the angiotensin II type 2 receptor and Alzheimer \u2019 s disease\u00a0?","volume":"2","author":"Gallo-Payet","year":"2011","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2022.101612_bib72","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1517\/14728222.8.1.7","article-title":"Angiotensin as a target for the treatment of Alzheimer \u2019 s disease, anxiety and depression","volume":"8","author":"Gard","year":"2004","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.arr.2022.101612_bib73","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mce.2008.11.003","article-title":"NADPH oxidase and Angiotensin II receptor signaling","volume":"302","author":"Garrido","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.arr.2022.101612_bib74","series-title":"The Pharmacological Basis of Therapeutics","author":"Gilman\u2019s","year":"1995"},{"key":"10.1016\/j.arr.2022.101612_bib75","first-page":"1","article-title":"Renin \u2013 angiotensin system gene expression and neurodegenerative diseases","author":"Goldstein","year":"2016","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.arr.2022.101612_bib76","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/physiol.00002.2008","article-title":"An intracellular Renin-Angiotensin system in neurons: fact, hypothesis, or fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology"},{"key":"10.1016\/j.arr.2022.101612_bib77","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neurobiolaging.2004.12.005","article-title":"Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis","volume":"27","author":"Gron","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101612_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2012.00164","article-title":"How does angiotensin AT 2 receptor activation help neuronal differentiation and improve neuronal pathological situations\u00a0?","volume":"3","author":"Guimond","year":"2012","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2022.101612_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/351758","article-title":"The Angiotensin II type 2 receptor in brain functions: an update","author":"Guimond","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib80","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520975743","article-title":"The intersection between COVID-19, the Gene Family of ACE2 and Alzheimer\u2019s disease","volume":"15","author":"Haghighi","year":"2020","journal-title":"Neurosci. Insights"},{"key":"10.1016\/j.arr.2022.101612_bib81","first-page":"E1","article-title":"Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series","author":"Hajjar","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2022.101612_bib82","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/gerona\/60.1.67","article-title":"Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population","volume":"60A","author":"Hajjar","year":"2005","journal-title":"J. Gerontol."},{"key":"10.1016\/j.arr.2022.101612_bib83","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archinternmed.2011.1391","article-title":"Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a Double-Blind Randomized Clinical Trial","volume":"172","author":"Hajjar","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.arr.2022.101612_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2318-9-48","article-title":"The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: role of the renin angiotensin system inhibition","volume":"9","author":"Hajjar","year":"2009","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.arr.2022.101612_bib85","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1007\/s11064-007-9305-1","article-title":"AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion","volume":"32","author":"Haktan","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2022.101612_bib86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.brainres.2010.07.017","article-title":"Telmisartan, a partial agonist of peroxisome proliferator-activated receptor \u03b3, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia","volume":"1353","author":"Haraguchi","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib87","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1471-4159.1988.tb02946.x","article-title":"Inability of [1251] Sar \u2019, Ile * -Angiotensin I1 to move between the blood and cerebrospinal fluid compartments","volume":"50","author":"Harding","year":"1988","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib88","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer \u2019 s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101612_bib89","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.lfs.2014.07.032","article-title":"Improvement in spatial memory dysfunction by telmisartan through reduction of brain angiotensin II and oxidative stress in experimental uremic mice","volume":"113","author":"Haruyama","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101612_bib90","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1212\/01.wnl.0000238102.04582.ec","article-title":"ACE activity in CSF of patients with mild cognitive impaiment and Alzheimer disease","volume":"67","author":"He","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101612_bib91","first-page":"1","article-title":"Alzheimer \u2019 s disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis","author":"Health","year":"2018","journal-title":"Aust. Psychiatry"},{"key":"10.1016\/j.arr.2022.101612_bib92","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/pds.3449","article-title":"Time until incident dementia among Medicare bene fi ciaries using centrally acting or non-centrally acting ACE inhibitors","volume":"22","author":"Hebert","year":"2013","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.arr.2022.101612_bib93","first-page":"181","article-title":"Neuroscience Letters An age effect on the association of common variants of ACE with Alzheimer \u2019 s disease","volume":"461","author":"Helbecque","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101612_bib94","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mcn.2005.03.012","article-title":"Angiotensin- ( 1 \u2013 7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas","volume":"29","author":"Hellner","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib95","doi-asserted-by":"crossref","first-page":"37644","DOI":"10.1074\/jbc.M508460200","article-title":"Amyloid \u03b2-protein is degraded by cellular Angiotensin- converting enzyme (ACE) and elevated by an ACE inhibitor","volume":"280","author":"Hemming","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib96","doi-asserted-by":"crossref","first-page":"37644","DOI":"10.1074\/jbc.M508460200","article-title":"Amyloid \u03b2-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor","volume":"280","author":"Hemming","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib97","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.nbd.2007.01.004","article-title":"Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid \u03b2 -protein metabolism in mouse models of Alzheimer disease","volume":"26","author":"Hemming","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101612_bib98","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(87)91637-4","article-title":"Presence of renin in primary neuronal and glial cells from rat brain","volume":"437","author":"Hermann","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib99","article-title":"Amyloid hypothesis: the emperor\u2019s new clothes?","volume":"78","author":"H\u00f8ilund-Carlsen","year":"2020","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00210-007-0192-4","article-title":"The effect of angiotensin II and IV on ERK1 \/ 2 and CREB signalling in cultured rat astroglial cells","volume":"376","author":"Holownia","year":"2007","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib101","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1253\/circj.CJ-12-0658","article-title":"Angiotensin-receptor blockers and risk of Alzheimer\u2019s disease in hypertension population","volume":"77","author":"Hsu","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.arr.2022.101612_bib102","doi-asserted-by":"crossref","first-page":"47863","DOI":"10.1074\/jbc.M104068200","article-title":"Angiotensin-converting enzyme degrades alzheimer amyloid\u03b2 -peptide (A\u03b2); retards A\u03b2 aggregation, deposition, fibril formation; and inhibits cytotoxicity","volume":"276","author":"Hu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib103","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/156720510793611592","article-title":"Tau in Alzheimer disease and related tauopathies","volume":"7","author":"Iqbal","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101612_bib104","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1007\/s12035-014-8830-6","article-title":"Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats tauheed","volume":"51","author":"Ishrat","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib105","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1038\/sj.jhh.1000991","article-title":"Clinical pharmacokinetics of angiotensin II ( AT 1) receptor blockers in hypertension","volume":"14","author":"Israili","year":"2000","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19030876","article-title":"Within the brain: the renin angiotensin system","volume":"19","author":"Jackson","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101612_bib107","doi-asserted-by":"crossref","DOI":"10.2174\/1567202613666160224124739","article-title":"Plasma Angiotensin-(1-7) is a potential biomarker for Alzheimer\u2019s disease","volume":"13","author":"Jiang","year":"2016","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.arr.2022.101612_bib108","article-title":"Angiotensin- ( 1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer \u2019 s disease","author":"Jiang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib109","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","article-title":"Direct stimulation of angiotensin II type 2 receptor enhances spatial memory","volume":"32","author":"Jing","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2022.101612_bib110","first-page":"1","article-title":"Stimulation of ACE2 \/ ANG ( 1 \u2013 7)\/ Mas axis by diminazene ameliorates Alzheimer \u2019 s disease in the D-galactose-ovariectomized rat model: role of PI3K \/ Akt pathway","author":"Kamel","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib111","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/cvr\/cvp073","article-title":"Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension","volume":"82","author":"Kang","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.arr.2022.101612_bib112","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3233\/JAD-170101","article-title":"The rationale and design of the reducing pathology in Alzheimer\u2019s disease through Angiotensin TaRgeting (RADAR) Trial","volume":"61","author":"Kehoe","year":"2017","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib113","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/hmg\/ddg094","article-title":"Haplotypes extending across ACE are associated with Alzheimer \u2019 s disease","volume":"12","author":"Kehoe","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.arr.2022.101612_bib114","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tins.2009.07.006","article-title":"Angiotensins in Alzheimer \u2019 s disease \u2013 friend or foe\u00a0?","volume":"32","author":"Kehoe","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-016-0217-7","article-title":"Angiotensin-converting enzyme 2 is reduced in Alzheimer \u2019 s disease in association with increasing amyloid- \u03b2 and tau pathology","volume":"8","author":"Kehoe","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib116","first-page":"197","article-title":"Evidence of endothelial dysfunction in the development of Alzheimer \u2019 s disease: is Alzheimer \u2019 s a vascular disorder\u00a0?","volume":"3","author":"Kelleher","year":"2013","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"10.1016\/j.arr.2022.101612_bib117","article-title":"Telmisartan Protects Against Aluminum-induced Alzheimer-like Pathological Changes In Rats","author":"Khalifa","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2022.101612_bib118","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jjcc.2012.08.004","article-title":"Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor \/ tropomyosin-related kinase B in hippocampus of hypertensive rats","volume":"60","author":"Kishi","year":"2012","journal-title":"J. Cardiol."},{"key":"10.1016\/j.arr.2022.101612_bib119","unstructured":"Kochanek, K.D., Murphy, S.L., Xu, J., Arias, E., Ph, D., 2019. National Vital Statistics Reports Deaths: Final Data for 2017 68."},{"key":"10.1016\/j.arr.2022.101612_bib120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2004.11.062","article-title":"ACE I \/ D polymorphism is a risk factor of Alzheimer \u2019 s disease but not of vascular dementia","volume":"377","author":"Kolsch","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101612_bib121","first-page":"590","article-title":"Enalaprilat inhibits zinc-dependent oligomerization of metal-binding domain of amyloid-beta isoforms and protects human neuroblastoma cells from toxic action of these isoforms","volume":"52","author":"Kozin","year":"2018","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.arr.2022.101612_bib122","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0006-8993(01)02100-X","article-title":"The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro","volume":"897","author":"Kramar","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib123","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-0115(96)02116-7","article-title":"Angiotensin II- and IV-induced changes in cerebral blood flow roles of AT 1 AT 2, and AT 4 receptor subtypes","volume":"68","author":"Kramar","year":"1997","journal-title":"Regul. Pept."},{"key":"10.1016\/j.arr.2022.101612_bib124","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.neuroscience.2008.06.023","article-title":"Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats","volume":"155","author":"Kumaran","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101612_bib125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1447-0594.2011.00746.x","article-title":"Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer \u2019 s disease","volume":"12","author":"Kume","year":"2012","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.arr.2022.101612_bib126","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.023","article-title":"Telmisartan reduces progressive accumulation of cellular amyloid beta and phosphorylated tau with inflammatory responses in aged spontaneously hypertensive stroke resistant rat","volume":"23","author":"Kurata","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.arr.2022.101612_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2017.00129","article-title":"Brain Renin-Angiotensin system and microglial polarization: implications for aging and neurodegeneration","volume":"9","author":"Labandeira-garcia","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib128","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006320","article-title":"Animal models of Alzheimer disease","volume":"2","author":"LaFerla","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101612_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2017.07.026","article-title":"Antihypertensive drugs","author":"Laurent","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2022.101612_bib130","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/01.HYP.0000125143.73301.94","article-title":"Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model","volume":"43","author":"Lavoie","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib131","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nlm.2011.10.003","article-title":"Neurobiology of learning and memory Angiotensin- ( 1 \u2013 7)\/ Mas axis integrity is required for the expression of object recognition memory","volume":"97","author":"Lazaroni","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.arr.2022.101612_bib132","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0028-3908(00)00188-X","article-title":"Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7","volume":"40","author":"Lee","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2022.101612_bib133","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1667\/RR2731.1","article-title":"Chronic administration of the Angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment","volume":"178","author":"Lee","year":"2012","journal-title":"Radiat. Res."},{"key":"10.1016\/j.arr.2022.101612_bib134","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/aje\/kwi202","article-title":"Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer \u2019 s disease","volume":"162","author":"Lehmann","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.arr.2022.101612_bib135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1471-4159.2003.01852.x","article-title":"Angiotensin AT 4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase ( IRAP)","volume":"86","author":"Lew","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.04-2960fje","article-title":"Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101612_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.arr.2022.101612_bib138","first-page":"1","article-title":"Angiotensin type 1a receptor deficiency decreases amyloid \u03b2 -protein generation and ameliorates brain amyloid pathology","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101612_bib139","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jnc.13386","article-title":"Direct anti-inflammatory effects of angiotensin-(1\u20137) on microglia","volume":"136","author":"Liu","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib140","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1074\/jbc.RA118.006420","article-title":"A clinical dose of angiotensin-converting enzyme ( ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer \u2019 s disease pathology in mice","volume":"294","author":"Liu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib141","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1471-4159.1998.70010424.x","article-title":"AT1 receptor-mediated nuclear translocation of Raf- 1 in brain neurons","volume":"70","author":"Lu","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2016.03.013","article-title":"Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia","author":"Mateos","year":"2016","journal-title":"BBA Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101612_bib143","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00109-008-0316-4","article-title":"Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice","volume":"86","author":"Maul","year":"2008","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.arr.2022.101612_bib144","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/jpet.112.199497","article-title":"Evaluation of metabolically stabilized Angiotensin IV analogs as procognitive \/ antidementia agents s","author":"Mccoy","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib145","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/547153a","article-title":"Stop Alzheimer\u2019s before it starts","volume":"547","author":"McDade","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.arr.2022.101612_bib146","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2022.101612_bib147","first-page":"1","article-title":"Perindopril ameliorates experimental Alzheimer \u2019 s disease progression: role of amyloid \u03b2 degradation, central estrogen receptor and hyperlipidemic \u2011 lipid raft signaling","author":"Messiha","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.arr.2022.101612_bib148","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/HYPERTENSIONAHA.112.192401","article-title":"Peroxisome proliferator-activated receptor-\u2425 activation with Angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice","volume":"59","author":"Min","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib149","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2990.2007.00885.x","article-title":"Angiotensin-converting enzyme ( ACE) levels and activity in Alzheimer \u2019 s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy","volume":"34","author":"Miners","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jnc.13411","article-title":"The contribution of neuroinflammation to amyloid toxicity in Alzheimer\u2019s disease","volume":"136","author":"Minter","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib151","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/169649","article-title":"Roles of brain Angiotensin II in cognitive function and dementia","volume":"2012","author":"Mogi","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib152","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2008.08.032","article-title":"Biochemical and biophysical research communications telmisartan prevented cognitive decline partly due to PPAR- c activation","volume":"375","author":"Mogi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101612_bib153","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3940(02)01182-5","article-title":"Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer \u2019 s disease","volume":"335","author":"Monastero","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101612_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113945","article-title":"Alzheimer\u2019s disease beyond amyloid: can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?","volume":"177","author":"Mullane","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib155","article-title":"FDA approval for Biogen\u2019s aducanumab sparks Alzheimer disease firestorm","volume":"20","author":"Mullard","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2022.101612_bib156","first-page":"1","article-title":"Transient mild cerebral ischemia significantly deteriorated cognitive impairment in a mouse model of Alzheimer \u2019 s disease via Angiotensin AT1 receptor","author":"Nakagawa","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib157","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nbd.2012.11.008","article-title":"AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression","volume":"51","author":"Namsolleck","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101612_bib158","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/jmg.37.9.695","article-title":"The ACE gene and Alzheimer \u2019 s disease susceptibility","volume":"37","author":"Narain","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.arr.2022.101612_bib159","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer\u2019s disease","volume":"34","author":"O\u2019Brien","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib160","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3233\/JAD-131694","article-title":"Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer \u2019 s disease","volume":"40","author":"O\u2019Caoimh","year":"2014","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib161","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101612_bib162","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3233\/JAD-150868","article-title":"Enalapril alone or co-administered with losartan rescues cerebrovascular dysfunction, but not mnemonic deficits or amyloidosis in a mouse model of Alzheimer \u2019 s disease","volume":"51","author":"Ongali","year":"2016","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib163","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nbd.2014.04.018","article-title":"Neurobiology of Disease Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive de fi cits in an Alzheimer \u2019 s disease model","volume":"68","author":"Ongali","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101612_bib164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2020.582345","article-title":"How does SARS-CoV-2 affect the central nervous system? A working hypothesis","volume":"11","author":"Panariello","year":"2020","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.arr.2022.101612_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-9-102","article-title":"Telmisartan directly ameliorates the neuronal inflammatory response to IL-1 \u03b2 partly through the JNK \/ c-Jun and NADPH oxidase pathways","volume":"9","author":"Pang","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2022.101612_bib166","first-page":"1","article-title":"Losartan improves cerebrovascular function in a mouse model of Alzheimer \u2019 s disease with combined overproduction of amyloid- b and transforming growth factor- b 1","volume":"0","author":"Papadopoulos","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2022.101612_bib167","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/CS20120461","article-title":"Angiotensin-(1\u20137): beyond the cardio-renal actions","volume":"124","author":"Passos-silva","year":"2013","journal-title":"Clin. Sci."},{"key":"10.1016\/j.arr.2022.101612_bib168","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-0115(98)00028-7","article-title":"Attenuation of scopolamine-induced spatial learning impairments by an angiotensin IV analog","volume":"74","author":"Pederson","year":"1998","journal-title":"Regul. Pept."},{"key":"10.1016\/j.arr.2022.101612_bib169","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ajhp\/57.suppl_1.S3","article-title":"Overview of the angiotensin-converting-enzyme inhibitors","volume":"57","author":"Piepho","year":"2000","journal-title":"Am. J. Health Pharm."},{"key":"10.1016\/j.arr.2022.101612_bib170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-130716","article-title":"Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer\u2019s Disease In The Absence Of Apolipoprotein E4 allele","volume":"37","author":"Qiu","year":"2013","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib171","first-page":"1","article-title":"Improvements of symptoms of Alzheimer ` s disease by inhibition of the angiotensin system","author":"Quitterer","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2022.101612_bib172","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1054\/npep.2000.0845","article-title":"Comparative studies on the memory- enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm","volume":"35","author":"Raghavendra","year":"2001","journal-title":"Neuropeptides"},{"key":"10.1016\/j.arr.2022.101612_bib173","doi-asserted-by":"crossref","first-page":"712","DOI":"10.2174\/1567205012666150701103107","article-title":"Neurobiology of Alzheimer \u2019 s disease: integrated molecular, physiological, anatomical, biomarker, and cognitive dimensions","volume":"12","author":"Raskin","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2022.101612_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells8050488","article-title":"Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer\u2019s disease","volume":"8","author":"Reddy","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101612_bib175","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropharm.2013.03.025","article-title":"Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke","volume":"0","author":"Regenhardt","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2022.101612_bib176","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.636754","article-title":"Circulating Angiotensin-(1\u20137) is reduced in Alzheimer\u2019s disease patients and correlates with white matter abnormalities: results from a pilot study","volume":"15","author":"Ribeiro","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib177","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/0929866527666191230103739","article-title":"Renin-Angiotensin system and Alzheimer\u2019s disease pathophysiology: from the potential interactions to therapeutic perspectives","volume":"27","author":"Ribeiro","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.arr.2022.101612_bib178","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2174\/1570159X15666170116143743","article-title":"The amyloid cascade hypothesis in Alzheimer \u2019 s disease: it \u2019 s time to change our mind","volume":"15","author":"Ricciarelli","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib179","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(95)00289-3","article-title":"Autoradiographic identification of brain angiotensin IV binding sites and differential c-Fos expression following intracerebroventricular injection of angiotensin II and IV in rats a","volume":"682","author":"Roberts","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib180","first-page":"18","article-title":"AT2 receptor-interacting proteins ATIPs in the brain","author":"Rodrigues-ferreira","year":"2013","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib181","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/glia.22765","article-title":"Interaction between NADPH-oxidase and rho-kinase in Angiotensin II-induced microglial activation","volume":"63","author":"Rodriguez-perez","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.arr.2022.101612_bib182","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.109.147843","article-title":"Direct Angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor \u03baB","volume":"55","author":"Rompe","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib183","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1523\/JNEUROSCI.0329-17.2017","article-title":"Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer \u2019 s disease","volume":"37","author":"Royea","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib184","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10571-006-9009-0","article-title":"Mechanisms of the anti-ischemic effect of Angiotensin II AT 1 receptor antagonists in the brain","volume":"26","author":"Saavedra","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib185","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0197-4580(00)00259-1","article-title":"Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer \u2019 s dementia","volume":"22","author":"Savaskan","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101612_bib186","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.hjh.0000220417.01397.6a","article-title":"Angiotensin II type 1 receptors in cerebral ischaemia- reperfusion: initiation of inflammation","volume":"24","author":"Schulz","year":"2006","journal-title":"J. Hypertens."},{"key":"10.1016\/j.arr.2022.101612_bib187","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.CIR.0000127955.36250.65","article-title":"Angiotensin type 1 receptor blockers induce peroxisome proliferator \u2013 activated receptor- \u2425 activity","volume":"109","author":"Schupp","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2022.101612_bib188","first-page":"163","article-title":"Angiotensin-converting enzyme levels and activity in Alzheimer \u2019 s disease: differences in brain and CSF ACE and association with ACE1 genotypes","volume":"1","author":"Scott","year":"2009","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.arr.2022.101612_bib189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/fn.2013.34190","article-title":"Molecular mechanisms of neuropathological changes in Alzheimer \u2019 s disease: a review","volume":"51","author":"Sery","year":"2013","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.arr.2022.101612_bib190","doi-asserted-by":"crossref","first-page":"17721","DOI":"10.1074\/jbc.M800013200","article-title":"Hydrogen peroxide promotes A\u03b2 production through JNK-dependent activation of -\u03b3-secretase","volume":"283","author":"Shen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib191","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1248\/bpb.b12-00387","article-title":"Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer \u2019 s disease incorporating additional cerebrovascular disease factors","volume":"35","author":"Shindo","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.arr.2022.101612_bib192","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.117.09167","article-title":"No brain Renin-Angiotensin system D\u00e9j\u00e0 vu all over again","volume":"69","author":"Sigmund","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib193","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1470320312459977","article-title":"Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer\u2019s disease type: possible involvement of PPAR-\u03b3 agonistic property","volume":"14","author":"Singh","year":"2012","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.arr.2022.101612_bib194","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health sudy","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.arr.2022.101612_bib195","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.neurobiolaging.2004.09.011","article-title":"ACE gene is associated with Alzheimer \u2019 s disease and atrophy of hippocampus and amygdala","volume":"26","author":"Sleegers","year":"2005","journal-title":"Neurol. Aging"},{"key":"10.1016\/j.arr.2022.101612_bib196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2013.08.091","article-title":"Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking","volume":"439","author":"Sohn","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101612_bib197","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11357-011-9360-z","article-title":"Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging","volume":"35","author":"Solfrizzi","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.arr.2022.101612_bib198","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/jgs.12415","article-title":"Angiotensin-converting enzyme inhibitors and Alzheimer\u2019s disease progression in older adults: results from the R\u00e9seau sur la Maladie d\u2019Alzheimer Franc\u00e7ais Cohort","volume":"61","author":"Soto","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101612_bib199","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/Angiotensin-(1\u20137)\/MAS axis of the renin-angiotensin system: focus on Angiotensin-(1\u20137) X","volume":"98","author":"Souza Santos","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2022.101612_bib200","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jacc.2019.12.033","article-title":"The Alzheimer \u2019 s disease amyloid-beta hypothesis in cardiovascular aging and disease","volume":"75","author":"Stakos","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2022.101612_bib201","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-cellbio-100818-125242","article-title":"Autophagy in neurons","volume":"35","author":"Stavoe","year":"2019","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2022.101612_bib202","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.3201232","article-title":"Astrocytes synthesize Angiotensinogen in brain","volume":"242","author":"Stornetta","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101612_bib203","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.tips.2019.07.008","article-title":"Neuro-regeneration therapeutic for Alzheimer \u2019 s dementia: perspectives on neurotrophic activity","volume":"40","author":"Sun","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.arr.2022.101612_bib204","first-page":"305","article-title":"Recent progress in signal transduction research of the Angiotensin II Type-1 receptor: protein kinases, vascular dysfunction and structural requirement","volume":"3","author":"Suzuki","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib205","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.109.138586","article-title":"Angiotensin receptor blocker prevented \u2424 -amyloid \u2013 induced cognitive impairment associated with recovery of neurovascular coupling","volume":"54","author":"Takeda","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib206","article-title":"Brain Renin-Angiotensin does it exist","volume":"69","author":"Thiel","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib207","doi-asserted-by":"crossref","first-page":"29615","DOI":"10.1074\/jbc.R800019200","article-title":"Amyloid precursor protein trafficking, processing, and function","volume":"283","author":"Thinakaran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101612_bib208","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1016\/j.febslet.2012.09.004","article-title":"Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains","volume":"586","author":"Tian","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2022.101612_bib209","first-page":"1","article-title":"Candesartan ameliorates brain inflammation associated with Alzheimer \u2019 s disease","author":"Torika","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2017.04.001","article-title":"Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer\u2019s disease mice","author":"Torika","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2022.101612_bib211","first-page":"1","article-title":"Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer\u2019s Disease Mice","author":"Torika","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2022.101612_bib212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0155823","article-title":"Telmisartan modulates glial activation: in vitro and in vivo studies","volume":"11","author":"Torika","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101612_bib213","doi-asserted-by":"crossref","DOI":"10.1007\/s11481-016-9703-8","article-title":"Angiotensin converting enzyme inhibitors ameliorate brain inflammation associated with microglial activation: possible implications for Alzheimer \u2019 s disease","author":"Torika","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib214","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s11481-016-9703-8","article-title":"Angiotensin converting enzyme inhibitors ameliorate brain inflammation associated with microglial activation: possible implications for Alzheimer \u2019 s disease","volume":"11","author":"Torika","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib215","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/HYPERTENSIONAHA.118.11775","article-title":"Pleiotropic benefits of the angiotensin receptor blocker candesartan in a mouse model of Alzheimer disease","volume":"72","author":"Trigiani","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib216","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/HYPERTENSIONAHA.109.136879","article-title":"Cognitive deficit in amyloid- \u2424 \u2013 injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated","volume":"54","author":"Tsukuda","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2022.101612_bib217","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biocel.2004.07.009","article-title":"The role of inflammation in Alzheimer \u2019 s disease","volume":"37","author":"Tuppo","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2022.101612_bib218","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s13311-014-0286-x","article-title":"Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury","volume":"11","author":"Umschweif","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2022.101612_bib219","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awv172","article-title":"Neurorestoration after traumatic brain injury through angiotensin II receptor blockage","volume":"138","author":"Villapol","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.arr.2022.101612_bib220","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.3233\/JAD-179941","article-title":"The amyloid-\u03b2 oligomer hypothesis: beginning of the third decade","volume":"64","author":"Viola","year":"2018","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib221","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuropharm.2013.11.022","article-title":"Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT1 receptor blockade and PPAR\u03b3 activation","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2022.101612_bib222","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1172\/JCI31547","article-title":"Valsartan lowers brain \u03b2-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2022.101612_bib223","first-page":"1","article-title":"Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion","author":"Wang","year":"2018","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.arr.2022.101612_bib224","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of glutamate and NMDA receptors in Alzheimer\u2019s disease","volume":"57","author":"Wang","year":"2017","journal-title":"J. Alzheimer Dis."},{"key":"10.1016\/j.arr.2022.101612_bib225","article-title":"Angiotensin-converting enzyme gene polymorphisms and risk for sporadic Alzheimer \u2019 s disease: a meta-analysis","author":"Wang","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2022.101612_bib226","first-page":"1","article-title":"Telmisartan ameliorates A\u03b2 oligomer-induced inflammation via PPAR\u03b3\/PTEN pathway in BV2 microglial cells","author":"Wang","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2022.101612_bib227","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/STROKEAHA.110.583948","article-title":"Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-\u2425 activation in mice with","author":"Washida","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2022.101612_bib228","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0196-9781(01)00475-2","article-title":"Angiotensin IV enhances LTP in rat dentate gyrus in vivo","volume":"22","author":"Wayner","year":"2001","journal-title":"Peptides"},{"key":"10.1016\/j.arr.2022.101612_bib229","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12688\/f1000research.14506.1","article-title":"Current understanding of Alzheimer\u2019s disease diagnosis and treatment [version 1; referees: 2 approved]","volume":"7","author":"Weller","year":"2018","journal-title":"F1000Research"},{"key":"10.1016\/j.arr.2022.101612_bib230","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3233\/JAD-161198","article-title":"Rationale and design of the mechanistic potential of antihypertensives in preclinical Alzheimer \u2019 s ( HEART) Trial","volume":"61","author":"Wharton","year":"2018","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib231","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/jgs.13627","article-title":"Renin-Angiotensin-System modulation may slow the conversion from mild cognitive impairment to Alzheimer \u2019 s disease","volume":"63","author":"Wharton","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101612_bib232","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2012-120763","article-title":"The effects of ramipril in individuals at risk for Alzheimer \u2019 s disease: results of a pilot clinical trial","volume":"32","author":"Wharton","year":"2012","journal-title":"J. Alzheimar\u2019s Dis."},{"key":"10.1016\/j.arr.2022.101612_bib233","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/1470320314526269","article-title":"Angiotensin II AT1 receptor blockade by telmisartan reduces impairment of spatial maze performance induced by both acute and chronic stress","volume":"16","author":"Wincewicz","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.arr.2022.101612_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2016.06.010","article-title":"Angiotensin II type 1 receptor blockade by telmisartan prevents stress-induced impairment of memory via HPA axis deactivation and up-regulation of brain-derived neurotrophic factor gene expression","author":"Wincewicz","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.arr.2022.101612_bib235","unstructured":"World Health Organization, 2017. Global action plan on the public health response to dementia 2017 - 2025 [WWW Document]. URL \u3008https:\/\/www.who.int\/health-topics\/dementia#tab=tab_3\u3009. (Accessed 12.4.20)."},{"key":"10.1016\/j.arr.2022.101612_bib236","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ddr.20328","article-title":"The brain Angiotensin IV\/AT4 receptor system as a new target for the treatment of Alzheimer\u2019s disease","volume":"70","author":"Wright","year":"2009","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.arr.2022.101612_bib237","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2013.00158","article-title":"A role for the brain RAS in Alzheimer \u2019s and Parkinson \u2019s diseases","volume":"4","author":"Wright","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2022.101612_bib238","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1523\/JNEUROSCI.19-10-03952.1999","article-title":"Contributions of the brain Angiotensin IV \u2013 AT 4 receptor subtype system to spatial learning","volume":"19","author":"Wright","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101612_bib239","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2007.10.009","article-title":"Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets","volume":"84","author":"Wright","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101612_bib240","first-page":"65","article-title":"Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases","author":"Wu","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101612_bib241","first-page":"1","article-title":"Angiotensin- ( 1-7) improves cognitive function in rats with chronic cerebral hypoperfusion","author":"Xie","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib242","article-title":"ACE2 \/ ANG- ( 1 \u2212 7)\/ Mas pathway in the brain: the axis of good ACE2 \/","volume":"300","author":"Xu","year":"2011","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2022.101612_bib243","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2010.07.006","article-title":"Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer \u2019 s disease","volume":"1352","author":"Yamada","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101612_bib244","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/ajpcell.00369.2010","article-title":"Angiotensin- ( 1 \u2013 7) increases neuronal potassium current via a nitric oxide-dependent mechanism","volume":"300","author":"Yang","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.arr.2022.101612_bib245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pbb.2013.10.027","article-title":"The effects of perindopril on cognitive impairment induced by D -galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress","volume":"114\u2013115","author":"Yang","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.arr.2022.101612_bib246","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1179\/1743132813Y.0000000295","article-title":"The effects of valsartan on cognitive deficits induced by aluminum trichloride and D -galactose in mice","volume":"36","author":"Yang","year":"2014","journal-title":"Neurol. Res."},{"key":"10.1016\/j.arr.2022.101612_bib247","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresbull.2014.09.010","article-title":"Protective effects of perindopril on d -galactose and aluminum trichloride induced neurotoxicity via the apoptosis of mitochondria-mediated intrinsic pathway in the hippocampus of mice","volume":"109","author":"Yang","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.arr.2022.101612_bib248","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/ageing\/afq179","article-title":"Angiotensin-converting enzyme gene and plasma protein level in Alzheimer \u2019 s disease in Taiwanese","author":"Yang","year":"2011","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2022.101612_bib249","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1620\/tjem.215.295","article-title":"Angiotensin-converting enzyme gene in Alzheimer \u2019 s disease","volume":"215","author":"Yang","year":"2008","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.arr.2022.101612_bib250","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1212\/WNL.0b013e3182a35228","article-title":"Antihypertensive drugs decrease risk of Alzheimer disease","volume":"81","author":"Yasar","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101612_bib251","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/cns.12015","article-title":"The neuroprotective effect of losartan through inhibiting AT1 \/ ASK1 \/ MKK4 \/ JNK3 pathway following cerebral I \/ R in rat hippocampal CA1 region","volume":"18","author":"Zhang","year":"2012","journal-title":"Neurosci. Ther."},{"key":"10.1016\/j.arr.2022.101612_bib252","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/j.1471-4159.2005.03275.x","article-title":"Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation","volume":"94","author":"Zhao","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101612_bib253","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2014.04.060","article-title":"Activation of the ACE2\/Ang-(1-7)\/Mas pathway reduces oxygen- glucose deprivation induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction","volume":"273","author":"Zheng","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101612_bib254","first-page":"1","article-title":"Central Angiotensin II stimulation promotes b amyloid production in Sprague Dawley rats","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101612_bib255","first-page":"8628","article-title":"Angiotensin-converting enzyme converts amyloid \u03b2 -protein 1 \u2013 42 ( A\u03b2 1 \u2013 42) to A\u03b2 1 \u2013 40, and its inhibition enhances brain a\u03b2 deposition","volume":"27","author":"Zou","year":"2007","journal-title":"Neurobiol. Dis."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372200054X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372200054X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:00:17Z","timestamp":1761591617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156816372200054X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":255,"alternative-id":["S156816372200054X"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101612","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer\u2019s disease: Past, present and future","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101612"}}