{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:52:57Z","timestamp":1761709977626,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.arr.2022.101657","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T09:33:50Z","timestamp":1653816830000},"page":"101657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Is COVID-19 really a geriatric syndrome?"],"prefix":"10.1016","volume":"79","author":[{"given":"Mohammad Amin","family":"Akbarzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Salar","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101657_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2020.06.029","article-title":"The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management","volume":"194","author":"Abou-Ismail","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.arr.2022.101657_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.14283\/jfa.2020.17","article-title":"Geriatric syndromes and SARS-Cov-2: more than just being old","volume":"9","author":"Aprahamian","year":"2020","journal-title":"J. Frailty Aging"},{"key":"10.1016\/j.arr.2022.101657_bib3","article-title":"Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections","volume":"11","author":"Bajaj","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.arr.2022.101657_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s43587-021-00114-7","article-title":"SARS-CoV-2, COVID-19 and the ageing immune system","volume":"1","author":"Bartleson","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2022.101657_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/infdis\/jiab039","article-title":"Evidence of severe acute respiratory syndrome coronavirus 2 replication and tropism in the lungs, airways, and vascular endothelium of patients with fatal coronavirus disease 2019: an autopsy case series","volume":"223","author":"Bhatnagar","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.arr.2022.101657_bib6","first-page":"374","article-title":"Activation of mucosal immunity and novel prophylactic and therapeutic strategy in combating COVID-19","volume":"1","author":"Chatterjee","year":"2021","journal-title":"Explor. Immunol."},{"key":"10.1016\/j.arr.2022.101657_bib7","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.3390\/ijerph17197234","article-title":"Analysis of fall risk factors in an aging population living in long-term care institutions in Spain: a retrospective cohort study","volume":"17","author":"D\u00edaz","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.arr.2022.101657_bib8","article-title":"Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: prospective observational cohort study","volume":"369","author":"Docherty","year":"2020","journal-title":"bmj"},{"key":"10.1016\/j.arr.2022.101657_bib9","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/bjh.16749","article-title":"COVID19 coagulopathy in Caucasian patients","volume":"189","author":"Fogarty","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.arr.2022.101657_bib10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2022.101657_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1532-5415.2007.01156.x","article-title":"Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept","volume":"55","author":"Inouye","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2022.101657_bib12","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1016\/S2468-2667(21)00077-3","article-title":"Are older people with disabilities neglected in the COVID-19 pandemic?","volume":"6","author":"Kuper","year":"2021","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.arr.2022.101657_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123158","article-title":"Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.arr.2022.101657_bib14","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.18632\/aging.103344","article-title":"Why does COVID-19 disproportionately affect older people?","volume":"12","author":"Mueller","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.arr.2022.101657_bib15","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e37","article-title":"Aging and the immune system: the impact of immunosenescence on viral infection, immunity and vaccine immunogenicity","volume":"19","author":"Oh","year":"2019","journal-title":"Immune Netw."},{"key":"10.1016\/j.arr.2022.101657_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-4933-7-7","article-title":"Factors that may impact on immunosenescence: an appraisal","volume":"7","author":"Ongr\u00e1di","year":"2010","journal-title":"Immun. Ageing. I A"},{"key":"10.1016\/j.arr.2022.101657_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12603-021-1720-5","article-title":"Interplay between inflammaging, frailty and nutrition in covid-19: preventive and adjuvant treatment perspectives","volume":"26","author":"Padilha de Lima","year":"2022","journal-title":"J. Nutr., Health Aging"},{"key":"10.1016\/j.arr.2022.101657_bib18","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.arr.2022.101657_bib19","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.arr.2022.101657_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233857","article-title":"High prevalence of geriatric syndromes in older adults","volume":"15","author":"Sanford","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101657_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101489","article-title":"Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: a systematic review and meta-analysis","volume":"72","author":"Veronese","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101657_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101513","article-title":"Biomarkers of ageing and frailty may predict COVID-19 severity","volume":"73","author":"Wanhella","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101657_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jtxs.12356","article-title":"Aging-related changes in quantity and quality of saliva: where do we stand in our understanding?","volume":"50","author":"Xu","year":"2019","journal-title":"J. Texture Stud."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372200099X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372200099X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:04:36Z","timestamp":1761591876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156816372200099X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":23,"alternative-id":["S156816372200099X"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101657","relation":{},"ISSN":["1568-1637"],"issn-type":[{"type":"print","value":"1568-1637"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is COVID-19 really a geriatric syndrome?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101657"}}