{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:53:36Z","timestamp":1792310016423,"version":"4.4.0"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MC072"],"award-info":[{"award-number":["ZR2020MC072"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH125"],"award-info":[{"award-number":["ZR2020QH125"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019ZD31"],"award-info":[{"award-number":["ZR2019ZD31"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2021ZDSYS11"],"award-info":[{"award-number":["2021ZDSYS11"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171131"],"award-info":[{"award-number":["32171131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071429"],"award-info":[{"award-number":["82071429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.arr.2022.101676","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T22:14:53Z","timestamp":1655504093000},"page":"101676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases"],"prefix":"10.1016","volume":"80","author":[{"given":"Jirong","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meining","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101676_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118070","article-title":"The role of K(ATP) channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson\u2019s disease","volume":"257","author":"Abdelkader","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1152\/physrev.1998.78.1.227","article-title":"Toward understanding the assembly and structure of KATP channels","volume":"78","author":"Aguilar-Bryan","year":"1998","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00441-017-2736-3","article-title":"Connexin 43 and ATP-sensitive potassium channels crosstalk: a missing link in hypoxia\/ischemia stress","volume":"371","author":"Ahmad Waza","year":"2018","journal-title":"Cell Tissue Res."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib4","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0008-6363(02)00836-2","article-title":"Role of the cardiac Na+\/H+ exchanger during ischemia and reperfusion","volume":"57","author":"Allen","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"Pt 2","key":"10.1016\/j.arr.2022.101676_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.2003.055889","article-title":"Modulation of the excitability of cholinergic basal forebrain neurones by KATP channels","volume":"554","author":"Allen","year":"2004","journal-title":"J. Physiol."},{"issue":"4944","key":"10.1016\/j.arr.2022.101676_bib6","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1126\/science.2305257","article-title":"Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels","volume":"247","author":"Amoroso","year":"1990","journal-title":"Science"},{"issue":"Pt 9","key":"10.1016\/j.arr.2022.101676_bib7","first-page":"2106","article-title":"Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes","volume":"127","author":"Arakel","year":"2014","journal-title":"J. Cell Sci."},{"issue":"5993","key":"10.1016\/j.arr.2022.101676_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/312446a0","article-title":"Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells","volume":"312","author":"Ashcroft","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.arr.2022.101676_bib9","first-page":"5","article-title":"Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease","author":"Atherton","year":"2016","journal-title":"Elife"},{"issue":"Suppl 4","key":"10.1016\/j.arr.2022.101676_bib10","article-title":"Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers","volume":"24","author":"Atwal","year":"1994","journal-title":"J. Cardiovasc Pharmacol."},{"issue":"36","key":"10.1016\/j.arr.2022.101676_bib11","doi-asserted-by":"crossref","first-page":"33369","DOI":"10.1074\/jbc.M103320200","article-title":"Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain","volume":"276","author":"Bajgar","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/ALN.0b013e31819dadc7","article-title":"Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels","volume":"110","author":"Bantel","year":"2009","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1021\/acsptsci.0c00168","article-title":"Sulfonylurea class of antidiabetic drugs inhibit acetylcholinesterase activity: unexplored auxiliary pharmacological benefit toward Alzheimer\u2019s disease","volume":"4","author":"Baruah","year":"2021","journal-title":"ACS Pharm. Transl. Sci."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1684\/epd.2015.0751","article-title":"The natural history and prognosis of epilepsy","volume":"17","author":"Beghi","year":"2015","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.arr.2022.101676_bib15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2741\/S415","article-title":"Parkinson\u2019s disease: a review","volume":"6","author":"Beitz","year":"2014","journal-title":"Front Biosci. Sch. Ed."},{"key":"10.1016\/j.arr.2022.101676_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105986","article-title":"The cardioprotective actions of statins in targeting mitochondrial dysfunction associated with myocardial ischaemia-reperfusion injury","volume":"175","author":"Bland","year":"2022","journal-title":"Pharm. Res."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1528-1167.2007.00915.x","article-title":"Anticonvulsant mechanisms of the ketogenic diet","volume":"48","author":"Bough","year":"2007","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCRESAHA.107.165324","article-title":"The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel","volume":"102","author":"Burke","year":"2008","journal-title":"Circ. Res."},{"issue":"Suppl 3","key":"10.1016\/j.arr.2022.101676_bib20","article-title":"Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains","volume":"53","author":"Campbell","year":"2004","journal-title":"Diabetes"},{"issue":"11\u201312","key":"10.1016\/j.arr.2022.101676_bib21","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.freeradbiomed.2012.03.008","article-title":"Mitochondrial compartmentalization of redox processes","volume":"52","author":"Cardoso","year":"2012","journal-title":"Free Radic. Biol. Med"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbrc.2006.09.045","article-title":"Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel","volume":"350","author":"Chai","year":"2006","journal-title":"Biochem Biophys. Res. Commun."},{"issue":"15","key":"10.1016\/j.arr.2022.101676_bib23","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1093\/emboj\/cdg376","article-title":"N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits","volume":"22","author":"Chan","year":"2003","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(00)01293-3","article-title":"Potassium channel openers prevent beta-amyloid toxicity in bovine vascular endothelial cells","volume":"290","author":"Chi","year":"2000","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.arr.2022.101676_bib25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/neu.480230915","article-title":"Excitotoxic cell death","volume":"23","author":"Choi","year":"1992","journal-title":"J. Neurobiol."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbabio.2004.01.003","article-title":"The human mitochondrial KATP channel is modulated by calcium and nitric oxide: a patch-clamp approach","volume":"1656","author":"Dahlem","year":"2004","journal-title":"Biochim Biophys. Acta"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/jnr.23777","article-title":"Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer\u2019s disease","volume":"95","author":"Daulatzai","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101676_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev-biochem-060614-034216","article-title":"Enjoy the trip: calcium in mitochondria back and forth","volume":"85","author":"De Stefani","year":"2016","journal-title":"Annu Rev. Biochem"},{"issue":"2\u20133","key":"10.1016\/j.arr.2022.101676_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0005-2728(02)00340-7","article-title":"Opening of potassium channels modulates mitochondrial function in rat skeletal muscle","volume":"1556","author":"Debska","year":"2002","journal-title":"Biochim Biophys. Acta"},{"issue":"23","key":"10.1016\/j.arr.2022.101676_bib30","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1007\/s00018-007-7332-3","article-title":"The regulation of ion channels and transporters by glycolytically derived ATP","volume":"64","author":"Dhar-Chowdhury","year":"2007","journal-title":"Cell Mol. Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.arr.2022.101676_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2004.05.088","article-title":"Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs","volume":"1019","author":"Domoki","year":"2004","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib32","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41419-018-0437-9","article-title":"Kir6.1\/K-ATP channel modulates microglia phenotypes: implication in Parkinson\u2019s disease","volume":"9","author":"Du","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresbull.2005.03.012","article-title":"The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia","volume":"66","author":"Erdo","year":"2005","journal-title":"Brain Res. Bull."},{"issue":"10107","key":"10.1016\/j.arr.2022.101676_bib34","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"van Es","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2022.101676_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.brainresbull.2018.01.001","article-title":"ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer\u2019s disease","volume":"137","author":"Esmaeili","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010906","article-title":"Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination","volume":"5","author":"Fogal","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physrev.00003.2015","article-title":"KATP channels in the cardiovascular system","volume":"96","author":"Foster","year":"2016","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1567205014666170417111859","article-title":"Tau in Alzheimer\u2019s disease: mechanisms and therapeutic strategies","volume":"15","author":"Gao","year":"2018","journal-title":"Curr. Alzheimer Res"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s003950070046","article-title":"Opening mitochondrial K(ATP) in the heart--what happens, and what does not happen","volume":"95","author":"Garlid","year":"2000","journal-title":"Basic Res Cardiol."},{"key":"10.1016\/j.arr.2022.101676_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.lfs.2016.11.006","article-title":"Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS\/NO pathway: Role for K(ATP) channel","volume":"168","author":"Gooshe","year":"2017","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1124\/jpet.102.034538","article-title":"(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization","volume":"303","author":"Gopalakrishnan","year":"2002","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.arr.2022.101676_bib42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2016.08.034","article-title":"Aberrant expression of the pore-forming K(ATP) channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer's disease","volume":"336","author":"Griffith","year":"2016","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib43","doi-asserted-by":"crossref","first-page":"H921","DOI":"10.1152\/ajpheart.00421.2003","article-title":"KATP channels and myocardial preconditioning: an update","volume":"285","author":"Gross","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1124\/jpet.102.036988","volume":"303","author":"Grover","year":"2002","journal-title":"J. Pharm. Exp. Ther."},{"issue":"18","key":"10.1016\/j.arr.2022.101676_bib45","first-page":"6133","article-title":"Diazoxide induces endoplasmic reticulum stress-related neuroprotection mediated by p38 MAPK against A\u03b225-35 insults","volume":"22","author":"Guan","year":"2018","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"10.1016\/j.arr.2022.101676_bib46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2014.03.032","article-title":"Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington\u05f3s disease","volume":"732","author":"Gupta","year":"2014","journal-title":"Eur. J. Pharm."},{"issue":"7","key":"10.1016\/j.arr.2022.101676_bib47","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/pedi.12447","article-title":"Molecular and clinical features of K(ATP) -channel neonatal diabetes mellitus in Japan","volume":"18","author":"Hashimoto","year":"2017","journal-title":"Pedia Diabetes"},{"key":"10.1016\/j.arr.2022.101676_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2022.110733","article-title":"Review: a history and perspective of mitochondria in the context of anoxia tolerance","volume":"260","author":"Hawrysh","year":"2022","journal-title":"Comp. Biochem Physiol. B Biochem Mol. Biol."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00021.2009","article-title":"Inwardly rectifying potassium channels: their structure, function, and physiological roles","volume":"90","author":"Hibino","year":"2010","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib50","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0330-20.2020","article-title":"\u03b1-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide","volume":"8","author":"Hill","year":"2021","journal-title":"eNeuro"},{"issue":"9046","key":"10.1016\/j.arr.2022.101676_bib51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer\u2019s disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"issue":"Pt 2","key":"10.1016\/j.arr.2022.101676_bib52","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1469-7793.1999.0347m.x","article-title":"ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria","volume":"519","author":"Holmuhamedov","year":"1999","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib53","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/01.STR.0000063404.27912.5B","article-title":"Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats","volume":"34","author":"Horiguchi","year":"2003","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.arr.2022.101676_bib54","doi-asserted-by":"crossref","first-page":"10301","DOI":"10.1002\/jcb.27372","article-title":"Preconditioned neurons with NaB and nicorandil, a favorable source for stroke cell therapy","volume":"119","author":"Hosseini","year":"2018","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.arr.2022.101676_bib55","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbi.2019.07.009","article-title":"Kir6.1\/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson\u2019s disease via promoting mitophagy","volume":"81","author":"Hu","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065154","article-title":"Pregabalin attenuates excitotoxicity in diabetes","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib57","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"issue":"6332","key":"10.1016\/j.arr.2022.101676_bib58","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/352244a0","article-title":"ATP-sensitive K+ channel in the mitochondrial inner membrane","volume":"352","author":"Inoue","year":"1991","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib59","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/cvr\/cvp109","article-title":"Orphan targets for reperfusion injury","volume":"83","author":"Inserte","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib60","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00210-003-0851-z","article-title":"Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart","volume":"369","author":"Ishida","year":"2004","journal-title":"Naunyn Schmiede Arch. Pharm."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib61","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1089\/ars.2013.5681","article-title":"Mitochondrial ion channels\/transporters as sensors and regulators of cellular redox signaling","volume":"21","author":"J","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib62","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1440-1789.2007.00823.x","article-title":"The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats","volume":"27","author":"Jiang","year":"2007","journal-title":"Neuropathology"},{"issue":"7","key":"10.1016\/j.arr.2022.101676_bib63","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024240","article-title":"Huntington\u2019s disease: mechanisms of pathogenesis and therapeutic strategies","volume":"7","author":"Jimenez-Sanchez","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101676_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173416","article-title":"Glibenclamide modulates microglial function and attenuates A\u03b2 deposition in 5XFAD mice","volume":"884","author":"Ju","year":"2020","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2022.101676_bib65","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2021.0241","article-title":"Tau pathology, metal dyshomeostasis and repetitive mild traumatic brain injury: an unexplored link paving the way for neurodegeneration","author":"Juan","year":"2022","journal-title":"J. Neurotrauma"},{"issue":"7835","key":"10.1016\/j.arr.2022.101676_bib66","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","article-title":"Discoveries in structure and physiology of mechanically activated ion channels","volume":"587","author":"Kefauver","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib67","first-page":"91","article-title":"[Longitudinal evaluation of early dementia of Alzheimer type using brain perfusion SPECT]","volume":"36","author":"Kogure","year":"1999","journal-title":"Kaku Igaku"},{"issue":"3\u20134","key":"10.1016\/j.arr.2022.101676_bib68","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000351247","article-title":"Effects of nicorandil in neuroprotective activation of PI3K\/AKT pathways in a cellular model of Alzheimer\u2019s disease","volume":"70","author":"Kong","year":"2013","journal-title":"Eur. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib69","first-page":"1966","article-title":"Nicorandil inhibits oxidative stress and amyloid-\u03b2 precursor protein processing in SH-SY5Y cells overexpressing APPsw","volume":"8","author":"Kong","year":"2015","journal-title":"Int. J. Clin. Exp. Med"},{"issue":"8","key":"10.1016\/j.arr.2022.101676_bib70","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/WNR.0b013e3283537615","article-title":"Protective effects of diazoxide against A\u03b2\u2082\u2085\u208b\u2083\u2085-induced PC12 cell apoptosis due to prevention of endoplasmic reticulum stress","volume":"23","author":"Kong","year":"2012","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2009.05.004","article-title":"Mitochondria and reactive oxygen species","volume":"47","author":"Kowaltowski","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"524","key":"10.1016\/j.arr.2022.101676_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5732","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La Joie","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib73","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbagen.2009.11.012","article-title":"5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches","volume":"1800","author":"Li","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(94)90647-5","article-title":"Glibenclamide selectively blocks ATP-sensitive K+ channels reconstituted from skeletal muscle","volume":"259","author":"Light","year":"1994","journal-title":"Eur. J. Pharm."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib75","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","article-title":"Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation","volume":"56","author":"Lima Giacobbo","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib76","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/emboj\/18.4.833","article-title":"Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons","volume":"18","author":"Liss","year":"1999","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.arr.2022.101676_bib77","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/nn1570","article-title":"K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons","volume":"8","author":"Liss","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib78","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3233\/JAD-2010-101017","article-title":"The KATP channel activator diazoxide ameliorates amyloid-\u03b2 and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer\u2019s disease","volume":"22","author":"Liu","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2005.10.018","article-title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells","volume":"394","author":"Liu","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101676_bib80","article-title":"cGMP and mitochondrial K(+) channels-Compartmentalized but closely connected in cardioprotection","author":"Lukowski","year":"2021","journal-title":"Br. J. Pharm."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib81","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer's disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/exnr.1996.0075","article-title":"Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson\u2019s disease","volume":"139","author":"Maneuf","year":"1996","journal-title":"Exp. Neurol."},{"issue":"8","key":"10.1016\/j.arr.2022.101676_bib83","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00415-017-8394-2","article-title":"Recent advances in epilepsy","volume":"264","author":"Manford","year":"2017","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/med.10060","article-title":"KATP channel openers: structure-activity relationships and therapeutic potential","volume":"24","author":"Mannhold","year":"2004","journal-title":"Med Res Rev."},{"issue":"11","key":"10.1016\/j.arr.2022.101676_bib85","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2174\/138955705774575282","article-title":"Second-generation K(ATP) channel openers","volume":"5","author":"Mannhold","year":"2005","journal-title":"Mini Rev. Med. Chem."},{"issue":"44","key":"10.1016\/j.arr.2022.101676_bib86","doi-asserted-by":"crossref","first-page":"30322","DOI":"10.1074\/jbc.M804318200","article-title":"Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor","volume":"283","author":"Masia","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib87","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2337\/db06-1275","article-title":"An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal","volume":"56","author":"Masia","year":"2007","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib88","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0006-291X(03)00627-2","article-title":"Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death","volume":"304","author":"Mattson","year":"2003","journal-title":"Biochem Biophys. Res Commun."},{"issue":"s1","key":"10.1016\/j.arr.2022.101676_bib89","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.3233\/JAD-201074","article-title":"Hypoxia, oxidative stress, and inflammation: three faces of neurodegenerative diseases","volume":"82","author":"Merelli","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib90","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/87455","article-title":"ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis","volume":"4","author":"Miki","year":"2001","journal-title":"Nat. Neurosci."},{"issue":"Suppl 3","key":"10.1016\/j.arr.2022.101676_bib91","article-title":"Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice","volume":"53","author":"Minami","year":"2004","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib92","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/mp.2016.187","article-title":"Blockade of the K(ATP) channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer\u2019s disease therapy","volume":"23","author":"Moriguchi","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib93","doi-asserted-by":"crossref","DOI":"10.1192\/j.eurpsy.2019.13","article-title":"Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders","volume":"63","author":"Morris","year":"2020","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.arr.2022.101676_bib94","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-10-4","article-title":"A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion","volume":"10","author":"Morrison","year":"2013","journal-title":"J. Neuroinflamm."},{"issue":"4\u20136","key":"10.1016\/j.arr.2022.101676_bib95","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/cac.10.4-6.413.417","article-title":"Neuroprotective role of astrocytic gap junctions in ischemic stroke","volume":"10","author":"Nakase","year":"2003","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.arr.2022.101676_bib96","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuroscience.2015.07.018","article-title":"Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats","volume":"303","author":"Negr\u00f3n","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101676_bib97","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0074-7742(07)82021-6","article-title":"The blockade of K(+)-ATP channels has neuroprotective effects in an in vitro model of brain ischemia","volume":"82","author":"Nistic\u00f2","year":"2007","journal-title":"Int Rev. Neurobiol."},{"issue":"5930","key":"10.1016\/j.arr.2022.101676_bib98","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/305147a0","article-title":"ATP-regulated K+ channels in cardiac muscle","volume":"305","author":"Noma","year":"1983","journal-title":"Nature"},{"issue":"10004","key":"10.1016\/j.arr.2022.101676_bib99","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O\u2019Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2022.101676_bib100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jns.2016.04.004","article-title":"Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum","volume":"366","author":"Obata","year":"2016","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib101","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21073","article-title":"Atherosclerosis and risk for dementia","volume":"61","author":"van Oijen","year":"2007","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib102","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00424-009-0771-y","article-title":"Human K(ATP) channelopathies: diseases of metabolic homeostasis","volume":"460","author":"Olson","year":"2010","journal-title":"Pflug. Arch."},{"issue":"7","key":"10.1016\/j.arr.2022.101676_bib103","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium-apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib104","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/jcbfm.2012.166","article-title":"Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia","volume":"33","author":"Ortega","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib105","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.expneurol.2012.02.010","article-title":"ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats","volume":"235","author":"Ortega","year":"2012","journal-title":"Exp. Neurol."},{"issue":"7771","key":"10.1016\/j.arr.2022.101676_bib106","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","article-title":"Identification of an ATP-sensitive potassium channel in mitochondria","volume":"572","author":"Paggio","year":"2019","journal-title":"Nature"},{"issue":"50","key":"10.1016\/j.arr.2022.101676_bib107","doi-asserted-by":"crossref","first-page":"32084","DOI":"10.1074\/jbc.271.50.32084","article-title":"Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides","volume":"271","author":"Paucek","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101676_bib108","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.bbadis.2018.01.013","article-title":"Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson\u2019s disease","author":"Peng","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib109","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/glia.22473","article-title":"Radixin expression in microglia after cortical stroke lesion","volume":"61","author":"Persson","year":"2013","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib110","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/01.shk.0000142250.85264.10","article-title":"Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm","volume":"22","author":"Pickkers","year":"2004","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib111","doi-asserted-by":"crossref","first-page":"183","DOI":"10.18869\/nirp.bcn.8.3.183","article-title":"The anti-parkinsonism effects of K(ATP) channel blockade in the 6-hydroxydopamine-induced animal model: the role of oxidative stress","volume":"8","author":"Piri","year":"2017","journal-title":"Basic Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pbiomolbio.2008.10.002","article-title":"Modeling K(ATP) channel gating and its regulation","volume":"99","author":"Proks","year":"2009","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib113","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cvr\/28.6.805","article-title":"Cellular pharmacology of potassium channel openers in vascular smooth muscle","volume":"28","author":"Quast","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arr.2022.101676_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2021.673177","article-title":"BACHD mice recapitulate the striatal parvalbuminergic interneuron loss found in Huntington\u2019s disease","volume":"15","author":"Rallapalle","year":"2021","journal-title":"Front. Neuroanat."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jcbfm.2015.164","article-title":"The neuropathology and cerebrovascular mechanisms of dementia","volume":"36","author":"Raz","year":"2016","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.arr.2022.101676_bib116","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.12659\/MSM.898400","article-title":"CD200 inhibits inflammatory response by promoting KATP channel opening in microglia cells in Parkinson\u2019s disease","volume":"22","author":"Ren","year":"2016","journal-title":"Med Sci. Monit."},{"issue":"15","key":"10.1016\/j.arr.2022.101676_bib117","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2174\/1381612054021015","article-title":"ATP-sensitive potassium channels","volume":"11","author":"Rodrigo","year":"2005","journal-title":"Curr. Pharm. Des."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib118","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study","volume":"57","author":"Ruitenberg","year":"2005","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib119","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JAD-160543","article-title":"Subclinical doses of ATP-sensitive potassium channel modulators prevent alterations in memory and synaptic plasticity induced by amyloid-\u03b2","volume":"57","author":"Salgado-Puga","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"9423","key":"10.1016\/j.arr.2022.101676_bib120","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(04)16305-8","article-title":"Parkinson\u2019s disease","volume":"363","author":"Samii","year":"2004","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.arr.2022.101676_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002718","article-title":"Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs","volume":"3","author":"Sanz-Blasco","year":"2008","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.arr.2022.101676_bib122","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nn.3185","article-title":"K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration","volume":"15","author":"Schiemann","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"18","key":"10.1016\/j.arr.2022.101676_bib123","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2169\/internalmedicine.8454-16","article-title":"K(ATP) channel mutations and neonatal diabetes","volume":"56","author":"Shimomura","year":"2017","journal-title":"Intern Med"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib124","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/07853890510007287","article-title":"Mutations in the Kir6.2 subunit of the KATP channel and permanent neonatal diabetes: new insights and new treatment","volume":"37","author":"Slingerland","year":"2005","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib125","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.bbrc.2018.04.128","article-title":"Sildenafil protects neuronal cells from mitochondrial toxicity induced by \u03b2-amyloid peptide via ATP-sensitive K(+) channels","volume":"500","author":"Son","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101676_bib126","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","article-title":"Alzheimer\u2019s disease","volume":"167","author":"Soria Lopez","year":"2019","journal-title":"Handb. Clin. Neurol."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib127","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1471-4159.2007.04963.x","article-title":"Role of K(ATP) channels in protection against neuronal excitatory insults","volume":"103","author":"Soundarapandian","year":"2007","journal-title":"J. Neurochem."},{"issue":"6030","key":"10.1016\/j.arr.2022.101676_bib128","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/316736a0","article-title":"Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane","volume":"316","author":"Spruce","year":"1985","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib129","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1440-1681.2009.05190.x","article-title":"ATP-sensitive potassium channels: a promising target for protecting neurovascular unit function in stroke","volume":"37","author":"Sun","year":"2010","journal-title":"Clin. Exp. Pharm. Physiol."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib130","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/sj.npp.1301501","article-title":"KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes","volume":"33","author":"Sun","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.arr.2022.101676_bib131","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.toxlet.2020.07.008","article-title":"Manganese induced nervous injury by \u03b1-synuclein accumulation via ATP-sensitive K(+) channels and GABA receptors","volume":"332","author":"Sun","year":"2020","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib132","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/bbrc.1997.7891","article-title":"Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria","volume":"241","author":"Suzuki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3 Pt 1","key":"10.1016\/j.arr.2022.101676_bib133","article-title":"Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs","volume":"269","author":"Terzic","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib134","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/mcne.2001.1048","article-title":"Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels","volume":"18","author":"Thomzig","year":"2001","journal-title":"Mol. Cell Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib135","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/j.2040-4603.2018.tb00049.x","article-title":"ATP-sensitive potassium channels and their physiological and pathophysiological roles","volume":"8","author":"Tinker","year":"2018","journal-title":"Compr. Physiol."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib136","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0197-4580(00)00111-1","article-title":"Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer\u2019s pathogenesis","volume":"21","author":"de la Torre","year":"2000","journal-title":"Neurobiol. Aging"},{"issue":"9557","key":"10.1016\/j.arr.2022.101676_bib137","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib138","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1124\/mol.104.003178","article-title":"Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain","volume":"66","author":"Wang","year":"2004","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib139","first-page":"237","article-title":"Role of Ca2+ and ion channels in the regulation of apoptosis under hypoxia","volume":"33","author":"Wang","year":"2018","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.arr.2022.101676_bib140","article-title":"Mitochondrial dynamics, mitophagy, and mitochondria-endoplasmic reticulum contact sites crosstalk under hypoxia","volume":"10","author":"Wang","year":"2022","journal-title":"Front Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib141","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.mehy.2008.05.021","article-title":"Potassium channels: possible new therapeutic targets in Parkinson's disease","volume":"71","author":"Wang","year":"2008","journal-title":"Med Hypotheses"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib142","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s004240050144","article-title":"Evidence against the association of the sulphonylurea receptor with endogenous Kir family members other than KATP in coronary vascular smooth muscle","volume":"432","author":"Wellman","year":"1996","journal-title":"Pflug. Arch."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib143","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer\u2019s disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib144","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jnr.22213","article-title":"K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production","volume":"88","author":"Xie","year":"2010","journal-title":"J. Neurosci. Res"},{"issue":"3","key":"10.1016\/j.arr.2022.101676_bib145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pbiomolbio.2006.04.001","article-title":"Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands","volume":"94","author":"Xie","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.arr.2022.101676_bib146","first-page":"127","article-title":"ATP-sensitive K(+) channels in the brain: sensors of hypoxic conditions","volume":"17","author":"Yamada","year":"2002","journal-title":"N. Physiol. Sci."},{"issue":"6","key":"10.1016\/j.arr.2022.101676_bib147","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.yjmcc.2004.11.020","article-title":"Neuroprotection by KATP channels","volume":"38","author":"Yamada","year":"2005","journal-title":"J. Mol. Cell Cardiol."},{"issue":"5521","key":"10.1016\/j.arr.2022.101676_bib148","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1126\/science.1059829","article-title":"Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure","volume":"292","author":"Yamada","year":"2001","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.arr.2022.101676_bib149","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1248\/yakushi.127.1173","article-title":"[Molecular mechanism of learning and memory based on the research for Ca2+\/calmodulin-dependent protein kinase II]","volume":"127","author":"Yamauchi","year":"2007","journal-title":"Yakugaku Zasshi"},{"issue":"9","key":"10.1016\/j.arr.2022.101676_bib150","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1755-5949.2012.00359.x","article-title":"Iptakalim enhances adult mouse hippocampal neurogenesis via opening Kir6.1-composed K-ATP channels expressed in neural stem cells","volume":"18","author":"Yang","year":"2012","journal-title":"CNS Neurosci. Ther."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib151","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0005-2728(97)00051-0","article-title":"The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol","volume":"1321","author":"Yarov-Yarovoy","year":"1997","journal-title":"Biochim Biophys. Acta"},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(96)01473-4","article-title":"Pre-synaptic effect of the ATP-sensitive potassium channel opener diazoxide on rat substantia nigra pars reticulata neurons","volume":"753","author":"Ye","year":"1997","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.arr.2022.101676_bib153","doi-asserted-by":"crossref","first-page":"C194","DOI":"10.1152\/ajpcell.00409.2019","article-title":"Functional modulation of sarcolemmal K(ATP) channels by atrial natriuretic peptide-elicited intracellular signaling in adult rabbit ventricular cardiomyocytes","volume":"319","author":"Zhang","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib154","first-page":"702","article-title":"\u03b2 amyloid hypothesis in Alzheimer\u2019s disease:pathogenesis,prevention,and management","volume":"41","author":"Zhang","year":"2019","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"10.1016\/j.arr.2022.101676_bib155","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.mcn.2018.08.006","article-title":"Deletion of Kir6.2\/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD","volume":"92","author":"Zhang","year":"2018","journal-title":"Mol. Cell Neurosci."},{"issue":"5","key":"10.1016\/j.arr.2022.101676_bib156","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jnr.21931","article-title":"Iptakalim ameliorates MPP+-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoK(ATP) channels","volume":"87","author":"Zhang","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"20","key":"10.1016\/j.arr.2022.101676_bib157","doi-asserted-by":"crossref","first-page":"8861","DOI":"10.1523\/JNEUROSCI.5686-12.2013","article-title":"EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability","volume":"33","author":"Zhao","year":"2013","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.arr.2022.101676_bib158","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1038\/sj.npp.1301381","article-title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation","volume":"32","author":"Zhou","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.arr.2022.101676_bib159","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0169-328X(02)00137-7","article-title":"Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells","volume":"101","author":"Zhou","year":"2002","journal-title":"Brain Res Mol. Brain Res."},{"issue":"2","key":"10.1016\/j.arr.2022.101676_bib160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5493\/wjem.v9.i2.14","article-title":"Localization of ATP-sensitive K(+) channel subunits in rat liver","volume":"9","author":"Zhou","year":"2019","journal-title":"World J. Exp. Med"},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib161","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.biocel.2004.10.008","article-title":"KATP channel: relation with cell metabolism and role in the cardiovascular system","volume":"37","author":"Zhuo","year":"2005","journal-title":"Int. J. Biochem Cell Biol."},{"issue":"4","key":"10.1016\/j.arr.2022.101676_bib162","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.neuron.2012.05.003","article-title":"In epilepsy, BAD is not really bad","volume":"74","author":"Ziviani","year":"2012","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.arr.2022.101676_bib163","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986","article-title":"Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus","volume":"6","author":"Zola-Morgan","year":"1986","journal-title":"J. Neurosci."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722001180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722001180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:01:39Z","timestamp":1778619699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163722001180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":163,"alternative-id":["S1568163722001180"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101676","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101676"}}