{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:07:22Z","timestamp":1792084042823,"version":"4.4.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/NM\/ NB\/2018\/40"],"award-info":[{"award-number":["DST\/NM\/ NB\/2018\/40"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.arr.2022.101681","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T12:13:19Z","timestamp":1656936799000},"page":"101681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Role of platelet in Parkinson\u2019s disease: Insights into pathophysiology &amp; theranostic solutions"],"prefix":"10.1016","volume":"80","author":[{"given":"Samir Kumar","family":"Beura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Ramachandra","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101681_bib1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fnagi.2019.00210","article-title":"Parkinson\u2019s disease: a systemic inflammatory disease accompanied by bacterial inflammagens","volume":"11","author":"Adams","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101681_bib2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.neurobiolaging.2014.01.009","article-title":"Plasma rich in growth factors (PRGF-Endoret) reduces neuropathologic hallmarks and improves cognitive functions in an Alzheimer\u2019s disease mouse model","volume":"35","author":"Anitua","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101681_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073118","article-title":"Intranasal delivery of plasma and platelet growth factors using PRGF-Endoret system enhances neurogenesis in a mouse model of Alzheimer\u2019s disease","volume":"8","author":"Anitua","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101681_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jconrel.2015.02.030","article-title":"Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-\u03baB-dependent inflammation process in a mouse model of Parkinson\u2019s disease","volume":"203","author":"Anitua","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.arr.2022.101681_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2022.101681_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson\u2019s disease: risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib7","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1182\/blood.2020005496","article-title":"Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI\/ITAM-mediated platelet activation programs","volume":"136","author":"Babur","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fneur.2019.00218","article-title":"Parkinson\u2019s disease and the environment","volume":"10","author":"Ball","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/00207454.2012.751534","article-title":"Role of platelets in neurodegenerative diseases: a universal pathophysiology","volume":"123","author":"Behari","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.arr.2022.101681_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12035-021-02587-4","article-title":"Role of neurons and glia cells in wound healing as a novel perspective considering platelet as a conventional player","volume":"59","author":"Beura","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101681_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.658273","article-title":"Phytochemicals as potential therapeutics for SARS-CoV-2-induced cardiovascular complications: thrombosis and platelet perspective","volume":"12","author":"Beura","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.arr.2022.101681_bib12","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2022.101681_bib13","first-page":"15","article-title":"Historical and cross-cultural perspectives on Parkinson\u2019s disease","author":"Blonder","year":"2018","journal-title":"J. Complement. Integr. Med."},{"key":"10.1016\/j.arr.2022.101681_bib14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0024-3205(91)90457-M","article-title":"Platelet peripheral benzodiazepine receptors are decreased in Parkinson\u2019s disease","volume":"48","author":"Bonuccelli","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101681_bib15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/jnnp.53.10.854","article-title":"Platelet monoamine oxidase B activity in parkinsonian patients","volume":"53","author":"Bonuccelli","year":"1990","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2022.101681_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.04.018","article-title":"The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice","volume":"333","author":"Borhani-Haghighi","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2022.101681_bib17","first-page":"3884","article-title":"DL\u20113\u2013n\u2011butylphthalide reduces microglial activation in lipopolysaccharide\u2011induced Parkinson\u2019s disease model mice","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biomaterials.2017.07.018","article-title":"Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson\u2019s disease","volume":"142","author":"Chou","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2022.101681_bib19","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.REV120.014294","article-title":"Targeting mitophagy in Parkinson\u2019s disease","volume":"296","author":"Clark","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101681_bib20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1600-0447.1988.tb06412.x","article-title":"Platelet MAO-B activity and the psychopathology of Parkinson\u2019s disease, senile dementia and multi-infarct dementia","volume":"78","author":"Danielczyk","year":"1988","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.arr.2022.101681_bib21","first-page":"457","article-title":"Decreasing activity of the platelet glutathione peroxidase in aged patients with Parkinson\u2019s disease","volume":"25","author":"De La Fourniere","year":"2000","journal-title":"Rev. Geriatr."},{"key":"10.1016\/j.arr.2022.101681_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.arr.2017.12.007","article-title":"The genetics of Parkinson disease","volume":"42","author":"Deng","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101681_bib23","first-page":"54","article-title":"[Activity of tyrosine hydroxylase and monoamine oxidase in human platelets during alcoholism]","volume":"36","author":"Drozdov","year":"1990","journal-title":"Vopr. Med. Khim."},{"key":"10.1016\/j.arr.2022.101681_bib24","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3389\/fnins.2018.00612","article-title":"Parkinson\u2019s disease: biomarkers, treatment, and risk factors","volume":"12","author":"Emamzadeh","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101681_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fnagi.2019.00151","article-title":"Decoding the role of platelets and related MicroRNAs in aging and neurodegenerative disorders","volume":"11","author":"Espinosa-Parrilla","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101681_bib26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/physiol.00020.2016","article-title":"New concepts and mechanisms of platelet activation signaling","volume":"32","author":"Estevez","year":"2017","journal-title":"Physiology"},{"key":"10.1016\/j.arr.2022.101681_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0022-510X(94)90056-6","article-title":"Platelet morphology in Parkinson\u2019s disease: an electron microscopic study","volume":"122","author":"Factor","year":"1994","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s007020050189","article-title":"Reduced platelet glutamate uptake in Parkinson\u2019s disease","volume":"106","author":"Ferrarese","year":"1999","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2022.101681_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105512","article-title":"Alternative platelet activation pathways and their role in neurodegenerative diseases","volume":"159","author":"Ferrer-Ravent\u00f3s","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101681_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.sjbs.2014.09.003","article-title":"An overview on the correlation of neurological disorders with cardiovascular disease","volume":"22","author":"Firoz","year":"2015","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib31","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.2174\/1381612825666190925163827","article-title":"A brief review of cardiovascular diseases, associated risk factors and current treatment regimes","volume":"25","author":"Flora","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2022.101681_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2006.01.062","article-title":"Characterization of the neuronal dopamine transporter DAT in human blood platelets","volume":"399","author":"Frankhauser","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101681_bib33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41582-020-0394-7","article-title":"Aspirin and ibuprofen could lower risk of LRRK2 Parkinson disease","volume":"16","author":"Fyfe","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib34","first-page":"9","article-title":"Platelet miRNA biosignature discriminates between dementia with Lewy bodies and Alzheimer\u2019s disease","author":"G\u00e1mez-Valero","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.arr.2022.101681_bib35","doi-asserted-by":"crossref","first-page":"8346","DOI":"10.1038\/s41598-019-44734-x","article-title":"Glutamate induces synthesis of thrombogenic peptides and extracellular vesicle release from human platelets","volume":"9","author":"Gautam","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5606\/phhb.dergisi.2016.07","article-title":"The relationship between Parkinson\u2018s disease and mean platelet volume","volume":"19","author":"Geyik","year":"2016","journal-title":"Park. Hast. Hareket Bozukluklar\u0131 Derg."},{"key":"10.1016\/j.arr.2022.101681_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/781857","article-title":"Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis","volume":"2014","author":"Ghoshal","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.arr.2022.101681_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244848","article-title":"Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8","volume":"16","author":"Goelz","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101681_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115635","article-title":"Prasugrel anti-ischemic effect in rats: modulation of hippocampal SUMO2\/3-I\u043aB\u03b1\/Ubc9 and SIRT-1\/miR-22 trajectories","volume":"426","author":"Gomaa","year":"2021","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.arr.2022.101681_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/term.2222","article-title":"The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways","author":"Gouel","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.arr.2022.101681_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090523","article-title":"Blood platelets in the progression of Alzheimer\u2019s disease","volume":"9","author":"Gowert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101681_bib42","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.410370604","article-title":"Low platelet mitochondrial complex I and complex II\/III activity in early untreated Parkinson\u2019s disease","volume":"37","author":"Haas","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1006\/bbrc.1997.6978","article-title":"NACP, a synaptic protein involved in Alzheimer\u2019s disease, is differentially regulated during megakaryocyte differentiation","volume":"237","author":"Hashimoto","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101681_bib44","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1007\/s12035-018-0923-1","article-title":"Cilostazol mediated nurr1 and autophagy enhancement: neuroprotective activity in rat rotenone PD model","volume":"55","author":"Hedya","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101681_bib45","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1111\/jth.13147","article-title":"Platelet secretory behaviour: as diverse as the granules\u2026 or not?","volume":"13","author":"Heijnen","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.arr.2022.101681_bib46","doi-asserted-by":"crossref","first-page":"11469","DOI":"10.1038\/s41598-017-11664-5","article-title":"Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells","volume":"7","author":"H\u00f6llerhage","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib47","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/FJC.0b013e3181b21472","article-title":"Celastrol, a triterpene extracted from Tripterygium wilfordii Hook F, inhibits platelet activation","volume":"54","author":"Hu","year":"2009","journal-title":"J. Cardiovasc. Pharm."},{"key":"10.1016\/j.arr.2022.101681_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2010.03.053","article-title":"dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson\u2019s disease","volume":"475","author":"Huang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101681_bib49","first-page":"2587","article-title":"On the role of platelet-generated amyloid beta peptides in certain amyloidosis health complications","volume":"0","author":"Inyushin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2022.101681_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1055\/s-0038-1650333","article-title":"The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes","volume":"75","author":"Israels","year":"1996","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.arr.2022.101681_bib51","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1182\/blood-2006-12-027698","article-title":"The growing complexity of platelet aggregation","volume":"109","author":"Jackson","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3892\/ijmm.2016.2822","article-title":"Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms","volume":"39","author":"Jayakumar","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2022.101681_bib53","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1182\/blood-2011-09-336933","article-title":"Transporters in human platelets: physiologic function and impact for pharmacotherapy","volume":"119","author":"Jedlitschky","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib54","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/jmf.2014.3241","article-title":"Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson\u2019s disease","volume":"18","author":"Jeong","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.arr.2022.101681_bib55","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2022.101681_bib56","first-page":"744","article-title":"The effect of endurance exercise and MitoQ intake on pathological characteristics in MPTP-induced animal model of Parkinson\u2019s disease","volume":"37","author":"Kim","year":"2020","journal-title":"J. Korean Appl. Sci. Technol."},{"key":"10.1016\/j.arr.2022.101681_bib57","doi-asserted-by":"crossref","first-page":"s39","DOI":"10.1161\/ATVBAHA.107.160226","article-title":"Translational therapeutics of dipyridamole","volume":"28","author":"Kim","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.arr.2022.101681_bib58","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson\u2019s disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101681_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/986254","article-title":"Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson\u2019s disease","volume":"2013","author":"Ko\u00e7er","year":"2013","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"10.1016\/j.arr.2022.101681_bib60","first-page":"785","article-title":"Thrombosis and platelets: an update","volume":"38","author":"Koupenova","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.arr.2022.101681_bib61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7150\/ijms.39074","article-title":"Parkin coordinates platelet stress response in diabetes mellitus: a big role in a small cell","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3389\/fnins.2019.00457","article-title":"Dysfunction of cellular proteostasis in Parkinson\u2019s disease","volume":"13","author":"Lehtonen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101681_bib63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3389\/fimmu.2020.00747","article-title":"Platelets in neurodegenerative conditions-friend or foe?","volume":"11","author":"Leiter","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2022.101681_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2022.01.060","article-title":"Ticagrelor for prevention of stroke and cognitive impairment in patients with vascular high-risk factors: a meta-analysis of randomized controlled trials","author":"Li","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.arr.2022.101681_bib65","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.arr.2022.101681_bib66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/09537100902721746","article-title":"Inhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP+) through ATP depletion: evidence for the reduced platelet activities in Parkinson\u2019s disease","volume":"20","author":"Lim","year":"2009","journal-title":"Platelets"},{"key":"10.1016\/j.arr.2022.101681_bib67","first-page":"9","article-title":"Celastrol inhibits dopaminergic neuronal death of Parkinson\u2019s disease through activating mitophagy","author":"Lin","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2022.101681_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1096-8652(199907)61:3<216::AID-AJH12>3.0.CO;2-B","article-title":"Parkinson\u2019s syndrome preceding clinical manifestation of Gaucher\u2019s disease","author":"Machaczka","year":"1999","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.arr.2022.101681_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258928","article-title":"Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity","volume":"16","author":"Madiha","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101681_bib70","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1161\/ATVBAHA.118.310955","article-title":"Novel antiplatelet therapies for atherothrombotic diseases","volume":"39","author":"Majithia","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.arr.2022.101681_bib71","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","article-title":"Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: from mechanism to therapy","volume":"46","author":"Malpartida","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(18)30127-3","article-title":"Risk factors for non-motor symptoms in Parkinson\u2019s disease","volume":"17","author":"Marinus","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib73","first-page":"21","article-title":"ROS in platelet biology: functional aspects and methodological insights","author":"Masselli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib74","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.3390\/ijms21176192","article-title":"Mitoquinone (MitoQ) inhibits platelet activation steps by reducing ROS levels","volume":"21","author":"M\u00e9ndez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib75","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrd2957","article-title":"Antiplatelet therapies for the treatment of cardiovascular disease","volume":"9","author":"Michelson","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2022.101681_bib76","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood-2013-11-462432","article-title":"Emerging roles for platelets as immune and inflammatory cells","volume":"123","author":"Morrell","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12929-019-0579-9","article-title":"The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen\/UVA) platelet concentrates","volume":"26","author":"Nebie","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib78","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002889","article-title":"Prasugrel, a platelet P2Y12 receptor antagonist, improves abnormal gait in a novel murine model of thrombotic hindlimb ischemia","volume":"5","author":"Ohno","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.arr.2022.101681_bib79","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1002\/mds.21013","article-title":"Ubiquitin-proteasome system and Parkinson\u2019s disease","volume":"21","author":"Olanow","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101681_bib80","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1515\/cclm-2015-0631","article-title":"Dopamine concentration in blood platelets is elevated in patients with head and neck paragangliomas","volume":"54","author":"Osinga","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.arr.2022.101681_bib81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40035-019-0165-9","article-title":"The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson\u2019s disease","volume":"8","author":"Pang","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2022.101681_bib82","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.119.044948","article-title":"Association of Parkinson disease with risk of cardiovascular disease and all-cause mortality: a nationwide, population-based cohort study","author":"Park","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2022.101681_bib83","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1182\/blood.V100.7.2506","article-title":"Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets","volume":"100","author":"Park","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02590","article-title":"Alpha synuclein in hematopoiesis and immunity","volume":"5","author":"Pei","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.arr.2022.101681_bib85","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2022.101681_bib86","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/trf.12874","article-title":"Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets","volume":"55","author":"Pienimaeki-Roemer","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.arr.2022.101681_bib87","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/ars.2013.5532","article-title":"Redox control of platelet functions in physiology and pathophysiology","volume":"21","author":"Pietraforte","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2022.101681_bib88","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2022.101681_bib89","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fimmu.2018.00406","article-title":"Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation, and deactivation of Th1, Th17, and Tregs during tissue inflammation","volume":"9","author":"Ponomarev","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2022.101681_bib90","doi-asserted-by":"crossref","unstructured":"Pontarollo, G., Acquasaliente, L., Radu, C.M., Peterle, D., Artusi, I., Pagotto, A., Uliana, F., Simioni, P., Negro, A., De Filippis, V., 2021. Human \u03b1-synuclein inhibits platelets aggregation in vitro by interfering with the \u03b1-thrombin\/protease-activated receptor 1 functional axis. bioRxiv.","DOI":"10.1101\/2021.03.28.437436"},{"key":"10.1016\/j.arr.2022.101681_bib91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/mds.27836","article-title":"Understanding the links between cardiovascular disease and Parkinson\u2019s disease","volume":"35","author":"Potashkin","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101681_bib92","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1242\/dmm.026294","article-title":"Mitochondrial dynamics in Parkinson\u2019s disease: a role for \u03b1-synuclein?","volume":"10","author":"Pozo Devoto","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.arr.2022.101681_bib93","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/0024-3205(93)90162-V","article-title":"[3H] dopamine uptake by platelet storage granules in Parkinson\u2019s disease","volume":"53","author":"Rabey","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101681_bib94","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.thromres.2010.01.009","article-title":"Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1","volume":"125","author":"Reheman","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.arr.2022.101681_bib95","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1038\/s41598-017-11643-w","article-title":"Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry","volume":"7","author":"Rijkers","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib96","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","article-title":"Alpha-synuclein: pathology, mitochondrial dysfunction and neuroinflammation in Parkinson\u2019s disease","volume":"109","author":"Rocha","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101681_bib97","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(02)00043-5","article-title":"Dipyridamole-induced increase in production of rat dopaminergic neurons from mesencephalic precursors","volume":"320","author":"Rodr\u00edguez-Pallares","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101681_bib98","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1161\/01.RES.0000267878.97021.ab","article-title":"Adhesion mechanisms in platelet function","volume":"100","author":"Ruggeri","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2022.101681_bib99","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00702-010-0446-z","article-title":"Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson\u2019s disease","volume":"117","author":"Sala","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2022.101681_bib100","doi-asserted-by":"crossref","DOI":"10.1161\/01.STR.22.12.1607","article-title":"Platelet aggregation in patients with Parkinson\u2019s disease","author":"Sharma","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2022.101681_bib101","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2010.06.009","article-title":"Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson\u2019s disease","volume":"480","author":"Shi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101681_bib102","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1182\/blood.V80.6.1470.1470","article-title":"Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein","volume":"80","author":"Silverstein","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.arr.2022.101681_bib103","first-page":"41","article-title":"Comparative analysis of structural changes in thrombocytes during Alzheimer\u2019s and Parkinson\u2019s diseases","author":"Simonidze","year":"2014","journal-title":"Georgian Med. N."},{"key":"10.1016\/j.arr.2022.101681_bib104","first-page":"19","article-title":"Systematic review on Parkinson\u2019s disease medications, emphasizing on three recently approved drugs to control Parkinson\u2019s symptoms","author":"Sivanandy","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.arr.2022.101681_bib105","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archpsyc.1977.01770170019001","article-title":"The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders","volume":"34","author":"Stahl","year":"1977","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.arr.2022.101681_bib106","article-title":"Initial assessment of \u03b1-synuclein structure in platelets","author":"Stefaniuk","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.arr.2022.101681_bib107","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/mds.28639","article-title":"\u03b1-Synuclein in plasma-derived extracellular vesicles is a potential biomarker of Parkinson\u2019s disease","volume":"36","author":"Stuendl","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101681_bib108","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00005344-200210000-00011","article-title":"New mechanism of action for cilostazol: interplay between adenosine and cilostazol in inhibiting platelet activation","volume":"40","author":"Sun","year":"2002","journal-title":"J. Cardiovasc. Pharm."},{"key":"10.1016\/j.arr.2022.101681_bib109","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson\u2019s disease","volume":"139 Suppl.","author":"Sveinbjornsdottir","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101681_bib110","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/1389450120666191112155654","article-title":"The therapeutic potential of quercetin in Parkinson\u2019s disease: insights into its molecular and cellular regulation","volume":"21","author":"Tamtaji","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.arr.2022.101681_bib111","first-page":"19","article-title":"Molecular and clinical issues about the risk of venous thromboembolism in older patients: a focus on Parkinson\u2019s disease and parkinsonism","author":"Tana","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101681_bib112","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bcmd.2018.09.001","article-title":"Ultrastructural changes in peripheral blood leukocytes in \u03b1-synuclein knockout mice","volume":"73","author":"Tashkandi","year":"2018","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.arr.2022.101681_bib113","first-page":"53","article-title":"Circulating extracellular vesicles: their role in tissue repair and regeneration","volume":"55","author":"Teixeira","year":"2016","journal-title":"Transfus. Apher. Sci. Off. J. World Apher. Assoc. Off. J. Eur. Soc. Haemapheresis"},{"key":"10.1016\/j.arr.2022.101681_bib114","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.lfs.2016.02.072","article-title":"Methamphetamine-induced dopaminergic toxicity prevented owing to the neuroprotective effects of salicylic acid","volume":"154","author":"Thrash-Williams","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2022.101681_bib115","series-title":"Homeostasis\u2013An Integrated Vision","article-title":"Platelets: from formation to function","author":"Twomey","year":"2018"},{"key":"10.1016\/j.arr.2022.101681_bib116","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2022.101681_bib117","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/cns.13429","article-title":"Development of early diagnosis of Parkinson\u2019s disease: illusion or reality","volume":"26","author":"Ugrumov","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2022.101681_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","author":"van der Meijden","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2022.101681_bib119","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-neuro-100720-034518","article-title":"Parkinson\u2019s disease genetics and pathophysiology","volume":"44","author":"V\u00e1zquez-V\u00e9lez","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.arr.2022.101681_bib120","first-page":"1","article-title":"Platelets, a reliable source for peripheral Alzheimer\u2019s disease biomarkers?","volume":"21","author":"Veitinger","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2022.101681_bib121","doi-asserted-by":"crossref","first-page":"14377","DOI":"10.1038\/s41598-018-32716-4","article-title":"Loss of the mitochondrial kinase PINK1 does not alter platelet function","volume":"8","author":"Walsh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib122","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.bbadis.2018.05.018","article-title":"MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1\u03b1","volume":"1864","author":"Xi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101681_bib123","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2013.11.051","article-title":"Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice","volume":"259","author":"Yabuki","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101681_bib124","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/09537104.2016.1257786","article-title":"The cellular basis of platelet secretion: emerging structure\/function relationships","volume":"28","author":"Yadav","year":"2017","journal-title":"Platelets"},{"key":"10.1016\/j.arr.2022.101681_bib125","doi-asserted-by":"crossref","first-page":"12088","DOI":"10.1038\/s41598-017-12205-w","article-title":"Effects of ticagrelor in a mouse model of ischemic stroke","volume":"7","author":"Yamauchi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101681_bib126","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/09537104.2014.989826","article-title":"DL-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase","volume":"26","author":"Ye","year":"2015","journal-title":"Platelets"},{"key":"10.1016\/j.arr.2022.101681_bib127","first-page":"1","article-title":"Identification of novel biomarkers in platelets for diagnosing Parkinson\u2019s disease","author":"Zhang","year":"2021","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.arr.2022.101681_bib128","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jnnp.70.2.229","article-title":"Platelet monoamine oxidase B and plasma beta-phenylethylamine in Parkinson\u2019s disease","volume":"70","author":"Zhou","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722001234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722001234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:07:35Z","timestamp":1761592055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163722001234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":128,"alternative-id":["S1568163722001234"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101681","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of platelet in Parkinson\u2019s disease: Insights into pathophysiology & theranostic solutions","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101681"}}