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Bull."},{"key":"10.1016\/j.arr.2022.101734_bib86","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1191\/1352458504ms1016oa","article-title":"Interferon-beta inhibits the expression of metalloproteinases in rat glial cell cultures: implications for multiple sclerosis pathogenesis and treatment","volume":"10","author":"Liuzzi","year":"2004","journal-title":"Mult. Scler."},{"key":"10.1016\/j.arr.2022.101734_bib87","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1742-2094-10-75","article-title":"The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion","volume":"10","author":"Lively","year":"2013","journal-title":"J. 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Res."},{"key":"10.1016\/j.arr.2022.101734_bib97","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2014.06.052","article-title":"Tumor necrosis factor-alpha-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation","volume":"578","author":"Matsumoto","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101734_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146779","article-title":"Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome","volume":"1736","author":"Matsuyama","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2022.101734_bib99","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.15252\/embr.201743922","article-title":"TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury","volume":"18","author":"Mazaheri","year":"2017","journal-title":"EMBO Rep."},{"issue":"1099\u20131108","key":"10.1016\/j.arr.2022.101734_bib100","article-title":"Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's Disease model","volume":"101","author":"Merlini","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2022.101734_bib101","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2013.02.001","article-title":"The alterations of Ca2+\/calmodulin\/CaMKII\/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia","volume":"538","author":"Min","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101734_bib102","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1161\/hs1201.100216","article-title":"Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion","volume":"32","author":"Miyamoto","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2022.101734_bib103","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nm.4482","article-title":"Pericyte degeneration causes white matter dysfunction in the mouse central nervous system","volume":"24","author":"Montagne","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2022.101734_bib104","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41467-017-00037-1","article-title":"Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway","volume":"8","author":"Morizawa","year":"2017","journal-title":"Nat. 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