{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:55:03Z","timestamp":1779148503281,"version":"3.51.4"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018255","name":"GLA University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.arr.2022.101783","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T12:27:40Z","timestamp":1667996860000},"page":"101783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism"],"prefix":"10.1016","volume":"83","author":[{"given":"Siva Prasad","family":"Panda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DSNBK","family":"Prasanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma Sankar","family":"Gorla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saikat","family":"Dewanjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101783_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-010-0678-x","article-title":"TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2","volume":"120","author":"Aizawa","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2022.101783_bib2","doi-asserted-by":"crossref","unstructured":"Amarya, S., Singh, K., Sabharwal, M., 2018. Ageing process and physiological changes, Gerontology. IntechOpen.","DOI":"10.5772\/intechopen.76249"},{"key":"10.1016\/j.arr.2022.101783_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874205X01206010001","article-title":"Genetic screening of the mitochondrial Rho GTPases MIRO1 and MIRO2 in Parkinson\u2019s disease","volume":"6","author":"Anvret","year":"2012","journal-title":"Open Neurol. J."},{"key":"10.1016\/j.arr.2022.101783_bib4","article-title":"Juvenile Parkinson disease","volume":"11","author":"Anwar","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.arr.2022.101783_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2022.101783_bib6","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1242\/jcs.038950","article-title":"Structural determinants of the cellular localization and shuttling of TDP-43","volume":"121","author":"Ayala","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2022.101783_bib7","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.1035-14.2015","article-title":"Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites","volume":"35","author":"Babic","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib8","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.1035-14.2015","article-title":"Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites","volume":"35","author":"Babic","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib9","first-page":"1","article-title":"TDP-43 and PINK1 mediate CHCHD10S59L mutation\u2013induced defects in Drosophila and in vitro","volume":"12","author":"Baek","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2022.101783_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.freeradbiomed.2021.11.015","article-title":"Mitochondrial chaperones in human health and disease","volume":"179","author":"Bahr","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2022.101783_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1513\/pats.200909-102JS","article-title":"Chaperone-mediated autophagy","volume":"7","author":"Bejarano","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.arr.2022.101783_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1177\/0891988710383572","article-title":"The genetics of Parkinson disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib13","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201744617","article-title":"Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation","volume":"19","author":"Betzer","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2022.101783_bib14","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/mds.28194","article-title":"Precision neurology for Parkinson\u2019s disease: coupling miro1\u2013based diagnosis with drug discovery","volume":"35","author":"Bharat","year":"2020","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.arr.2022.101783_bib15","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/S1353-8020(11)70004-9","article-title":"Autosomal recessive parkinsonism","volume":"18 Suppl","author":"Bonifati","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib16","doi-asserted-by":"crossref","first-page":"11611","DOI":"10.1074\/jbc.M115.642017","article-title":"Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes","volume":"290","author":"B\u00f6ttinger","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101783_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40263-014-0221-z","article-title":"Role of apomorphine in the treatment of Parkinson\u2019s disease","volume":"29","author":"Boyle","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.arr.2022.101783_bib18","first-page":"589","article-title":"c-Abl and Parkinson\u2019s disease: mechanisms and therapeutic potential","volume":"7","author":"Brahmachari","year":"2017","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2015.05.029","article-title":"Transcriptional regulation of the alpha-synuclein gene in human brain tissue","volume":"599","author":"Brenner","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101783_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105734","article-title":"Downregulation of lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson's disease through the inhibition of the PI3K\/Akt signaling pathway","volume":"75","author":"Cai","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2022.101783_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/cells9010150","article-title":"Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative diseases","volume":"9","author":"Cai","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101783_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.freeradbiomed.2013.03.021","article-title":"Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease","volume":"61","author":"Casani","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2022.101783_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000329999","article-title":"Role of p53 in neurodegenerative diseases","volume":"9","author":"Chang","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib24","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1038\/emboj.2011.204","article-title":"Autoregulation of Parkin activity through its ubiquitin\u2010like domain. The","volume":"30","author":"Chaugule","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2022.101783_bib25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/acschemneuro.8b00447","article-title":"Exploring the roles of post-translational modifications in the pathogenesis of Parkinson\u2019s disease using synthetic and semisynthetic modified \u03b1-synuclein","volume":"10","author":"Chen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2018.04.018","article-title":"Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NF\u03baB pathway signaling targets in LPS\/IFN\u03b3-activated BV-2 microglia cells","volume":"320","author":"Cobourne-Duval","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2022.101783_bib27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.molmed.2011.06.004","article-title":"TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies","volume":"17","author":"Cohen","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2022.101783_bib28","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2022.101783_bib29","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: a review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2022.101783_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbabio.2010.05.005","article-title":"Mitochondria: the calcium connection","volume":"1797","author":"Contreras","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101783_bib31","first-page":"3172","article-title":"Potential of PINK1 and PARKIN proteins as biomarkers for active multiple sclerosis: a Japanese cohort study","author":"Cossu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2022.101783_bib32","first-page":"162","article-title":"Amantadine and apomorphine: interactions on striatal dopamine receptors","author":"Cox","year":"1975","journal-title":"Proc. West. Pharmacol. Soc."},{"key":"10.1016\/j.arr.2022.101783_bib33","first-page":"3878","article-title":"Tetramethylpyrazine ameliorates isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation via miR-150 in rats","volume":"20","author":"Cui","year":"2020","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.arr.2022.101783_bib34","doi-asserted-by":"crossref","first-page":"eaba1659","DOI":"10.1126\/scitranslmed.aba1659","article-title":"Promising disease-modifying therapies for Parkinson\u2019s disease","volume":"11","author":"Dawson","year":"2019","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.arr.2022.101783_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/jpm11020069","article-title":"Proteotoxicity: a fatal consequence of environmental pollutants-induced impairments in protein clearance machinery","volume":"11","author":"Devi","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.arr.2022.101783_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2015.12.008","article-title":"Miro sculpts mitochondrial dynamics in neuronal health and disease","volume":"90","author":"Devine","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2012.02.032","article-title":"TDP-43 aggregation in neurodegeneration: are stress granules the key","volume":"1462","author":"Dewey","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2022.101783_bib38","doi-asserted-by":"crossref","first-page":"a009258","DOI":"10.1101\/cshperspect.a009258","article-title":"Parkinson\u2019s disease and parkinsonism: neuropathology","volume":"2","author":"Dickson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101783_bib39","series-title":"Laser Capture Microdissection","first-page":"319","article-title":"Isolation of amyloid plaques and neurofibrillary tangles from archived Alzheimer\u2019s disease tissue using laser-capture microdissection for downstream proteomics","author":"Drummond","year":"2018"},{"key":"10.1016\/j.arr.2022.101783_bib40","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/mds.25098","article-title":"Donepezil in Parkinson's disease dementia: a randomized, double-blind efficacy and safety study","volume":"27","author":"Dubois","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib41","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/pro.3839","article-title":"Miro: a molecular switch at the center of mitochondrial regulation","volume":"29","author":"Eberhardt","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.arr.2022.101783_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceb.2015.01.002","article-title":"PINK1\/Parkin-mediated mitophagy in mammalian cells","volume":"33","author":"Eiyama","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib43","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3389\/fnins.2018.00612","article-title":"Parkinson\u2019s disease: biomarkers, treatment, and risk factors","volume":"12","author":"Emamzadeh","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib44","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/mds.27475","article-title":"Opicapone for the treatment of Parkinson's disease: a review of a new licensed medicine","volume":"33","author":"Fabbri","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib45","doi-asserted-by":"crossref","first-page":"4246350","DOI":"10.1155\/2019\/4246350","article-title":"Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells","volume":"2019","author":"Faustini","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2022.101783_bib46","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/cbin.11523","article-title":"Effective inhibition of miR\u2010330\/SHIP1\/NF\u2010\u03baB signaling pathway via miR\u2010330 sponge repolarizes microglia differentiation","volume":"45","author":"Feng","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.arr.2022.101783_bib47","unstructured":"Foundation, P.D., 2013. Mannitol - A natural food supplement shown toarrest Parkinson's progression and reverse symptoms."},{"key":"10.1016\/j.arr.2022.101783_bib48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fncel.2014.00182","article-title":"miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway","volume":"8","author":"Fragkouli","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib49","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1021\/acschembio.9b00481","article-title":"Small molecule targeting TDP-43\u2019s RNA recognition motifs reduces locomotor defects in a Drosophila model of amyotrophic lateral sclerosis (ALS)","volume":"14","author":"Fran\u00e7ois-Moutal","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.wco.0000170951.08924.3d","article-title":"Genetics of Parkinson's disease","volume":"18","author":"Gasser","year":"2005","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib51","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.3390\/cells10123389","article-title":"Parkin beyond Parkinson\u2019s disease\u2014a functional meaning of parkin downregulation in TDP-43 proteinopathies","volume":"10","author":"Gaweda-Walerych","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101783_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101529","article-title":"Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria","volume":"73","author":"Gowda","year":"2022","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2022.101783_bib53","first-page":"627","article-title":"[Amyloidosis: a model of misfolded protein disorder]","volume":"21","author":"Grateau","year":"2005","journal-title":"Med. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib54","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3389\/fneur.2020.00587","article-title":"The Emerging Role of RHOT1\/Miro1 in the Pathogenesis of Parkinson's Disease","volume":"11","author":"Grossmann","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2017.04.004","article-title":"Deregulation of \u03b1-synuclein in Parkinson\u2019s disease: insight from epigenetic structure and transcriptional regulation of SNCA","volume":"154","author":"Guhathakurta","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101783_bib56","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.arr.2022.101783_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101336","article-title":"Post-translational modifications: regulators of neurodegenerative proteinopathies","volume":"68","author":"Gupta","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2022.101783_bib58","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tibtech.2013.05.004","article-title":"Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation","volume":"31","author":"Hamrang","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.arr.2022.101783_bib59","first-page":"241","article-title":"[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease]","volume":"44","author":"Hattori","year":"2004","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.arr.2022.101783_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.07.007","article-title":"The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent alpha-synuclein in experimental multiple system atrophy","volume":"1865","author":"Herrera-Vaquero","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1131\u20131140","key":"10.1016\/j.arr.2022.101783_bib61","article-title":"Miro1 marks Parkinson\u2019s disease subset and Miro1 reducer rescues neuron loss in Parkinson\u2019s models","volume":"30","author":"Hsieh","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.arr.2022.101783_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.161","article-title":"Heat shock proteins: biological functions, pathological roles, and therapeutic opportunities","volume":"2020","author":"Hu","year":"2022","journal-title":"MedComm"},{"key":"10.1016\/j.arr.2022.101783_bib63","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s10495-010-0466-z","article-title":"Ubiquitin\/proteasome pathway impairment in neurodegeneration: therapeutic implications","volume":"15","author":"Huang","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.arr.2022.101783_bib64","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/mds.10467","article-title":"Mutation analysis of the parkin gene in Russian families with autosomal recessive juvenile parkinsonism","volume":"18","author":"Illarioshkin","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/ijms19020489","article-title":"Physicochemical properties of the mammalian molecular chaperone HSP60","volume":"19","author":"Ishida","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib66","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.5692\/clinicalneurol.50.1022","article-title":"FTLD\/ALS as TDP-43 proteinopathies","volume":"50","author":"Ishihara","year":"2010","journal-title":"Rinsho Shinkeigaku Clin. Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib67","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0706932","article-title":"Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post\u2010ischaemic functional recovery in rats in vivo","volume":"149","author":"de J Garc\u00eda\u2010Rivas","year":"2006","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.arr.2022.101783_bib68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0955-2863(01)00215-7","article-title":"Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies","volume":"13","author":"Kanski","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.arr.2022.101783_bib69","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.1007\/s12035-018-0927-x","article-title":"Understanding Miro GTPases: implications in the treatment of neurodegenerative disorders","volume":"55","author":"Kay","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101783_bib70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12013-011-9176-6","article-title":"PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications","volume":"60","author":"Kessler","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.arr.2022.101783_bib71","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuro.2013.08.005","article-title":"Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease","volume":"39","author":"Khurana","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.arr.2022.101783_bib72","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4162\/nrp.2017.11.2.114","article-title":"Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson's disease","volume":"11","author":"Kim","year":"2017","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.arr.2022.101783_bib73","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bbrc.2008.10.104","article-title":"PINK1 controls mitochondrial localization of Parkin through direct phosphorylation","volume":"377","author":"Kim","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101783_bib74","doi-asserted-by":"crossref","first-page":"a008888","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson\u2019s disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101783_bib75","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-012-0100-8","article-title":"PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity","volume":"34","author":"Koh","year":"2012","journal-title":"Mol. Cells"},{"key":"10.1016\/j.arr.2022.101783_bib76","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1074\/jbc.M110.180034","article-title":"Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance","volume":"286","author":"Koshiba","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101783_bib77","series-title":"Pharm. Biotechnol","first-page":"33","article-title":"Protein stability and characterization","author":"Koulov","year":"2019"},{"key":"10.1016\/j.arr.2022.101783_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004140","article-title":"A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability","volume":"10","author":"Kriegenburg","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.arr.2022.101783_bib79","doi-asserted-by":"crossref","first-page":"jcs226084","DOI":"10.1242\/jcs.226084","article-title":"Motor proteins at the mitochondria\u2013cytoskeleton interface","volume":"134","author":"Kruppa","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2022.101783_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101078","article-title":"Ubiquitin biology in neurodegenerative disorders: from impairment to therapeutic strategies","volume":"61","author":"Kumar","year":"2020","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2022.101783_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41525-022-00319-8","article-title":"Synaptosome microRNAs regulate synapse functions in Alzheimer\u2019s disease","volume":"7","author":"Kumar","year":"2022","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.arr.2022.101783_bib82","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1534\/genetics.112.146704","article-title":"Long noncoding RNAs: past, present, and future","volume":"193","author":"Kung","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.arr.2022.101783_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-021-00775-x","article-title":"The role of noncoding RNAs in Parkinson\u2019s disease: biomarkers and associations with pathogenic pathways","volume":"28","author":"Kuo","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib84","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1093\/nar\/gkt1407","article-title":"The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG-and TG-rich nucleic acids","volume":"42","author":"Kuo","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arr.2022.101783_bib85","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2022.101783_bib86","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.devcel.2016.03.023","article-title":"Polo kinase phosphorylates miro to control ER-mitochondria contact sites and mitochondrial Ca2+ homeostasis in neural stem cell development","volume":"37","author":"Lee","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.arr.2022.101783_bib87","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/1073858415588265","article-title":"Ca2+ dependence of synaptic vesicle endocytosis","volume":"22","author":"Leitz","year":"2016","journal-title":"Neuroscientist"},{"key":"10.1016\/j.arr.2022.101783_bib88","first-page":"26","article-title":"Transplantation of neural precursor cells in the treatment of Parkinson disease: an efficacy and safety analysis","author":"Leng","year":"2016","journal-title":"Turk. Neurosurg."},{"key":"10.1016\/j.arr.2022.101783_bib89","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s13577-017-0187-5","article-title":"MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson\u2019s disease by targeting Nlrp3","volume":"31","author":"Li","year":"2018","journal-title":"Hum. Cell"},{"key":"10.1016\/j.arr.2022.101783_bib90","first-page":"14","article-title":"MicroRNAs play a role in parkinson\u2019s disease by regulating microglia function: from pathogenetic involvement to therapeutic potential","author":"Li","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.633727","article-title":"The membrane interaction of alpha-synuclein","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2051-5960-1-49","article-title":"Reducing TDP-43 aggregation does not prevent its cytotoxicity","volume":"1","author":"Liu","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2022.101783_bib93","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s11064-020-03157-1","article-title":"LncRNA NEAT1 regulates the development of Parkinson\u2019s disease by targeting AXIN1 via sponging miR-212-3p","volume":"46","author":"Liu","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2022.101783_bib94","first-page":"5","article-title":"Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1","author":"Liu","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.arr.2022.101783_bib95","doi-asserted-by":"crossref","first-page":"321","DOI":"10.15252\/embj.201696380","article-title":"Miro proteins coordinate microtubule\u2010and actin\u2010dependent mitochondrial transport and distribution","volume":"37","author":"L\u00f3pez\u2010Dom\u00e9nech","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2022.101783_bib96","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1517\/14656566.2016.1149163","article-title":"New and emerging medical therapies in Parkinson\u2019s disease","volume":"17","author":"Lotia","year":"2016","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.arr.2022.101783_bib97","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/nsmb.2698","article-title":"Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43","volume":"20","author":"Lukavsky","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib98","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/jps.21566","article-title":"Protein aggregation: pathways, induction factors and analysis","volume":"98","author":"Mahler","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib99","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.biocel.2004.02.013","article-title":"Mechanisms of chaperone-mediated autophagy","volume":"36","author":"Majeski","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib100","doi-asserted-by":"crossref","first-page":"jcs255844","DOI":"10.1242\/jcs.255844","article-title":"Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19","volume":"134","author":"Majstrowicz","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2022.101783_bib101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnmol.2020.00098","article-title":"Therapeutic approaches targeting protein aggregation in amyotrophic lateral sclerosis","volume":"13","author":"Malik","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib102","unstructured":"Marisa Wexler, M., 2022. Trial Failure of Antibody Targeting Alpha-synuclein Detailed."},{"key":"10.1016\/j.arr.2022.101783_bib103","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0070-2153(05)73007-6","article-title":"Chaperone-mediated autophagy in aging and disease","volume":"73","author":"Massey","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib104","first-page":"757","article-title":"Parkinson\u2019s disease drug therapies in the clinical trial pipeline: 2020","volume":"10","author":"McFarthing","year":"2020","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib105","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/mds.28218","article-title":"A phase 1 randomized trial of specific active alpha-synuclein immunotherapies PD01A and PD03A in multiple system atrophy","volume":"35","author":"Meissner","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib106","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/NRL.0000000000000188","article-title":"Therapy with mesenchymal stem cells in Parkinson disease: history and perspectives","volume":"23","author":"Mendes Filho","year":"2018","journal-title":"Neurologist"},{"key":"10.1016\/j.arr.2022.101783_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-021-00503-x","article-title":"TDP-43 pathology in Alzheimer\u2019s disease","volume":"16","author":"Meneses","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2022.101783_bib108","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fnins.2018.00821","article-title":"Heat shock proteins regulatory role in neurodevelopment","volume":"12","author":"Miller","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2019.04.029","article-title":"Therapeutic approaches to enhance PINK1\/Parkin mediated mitophagy for the treatment of Parkinson\u2019s disease","volume":"705","author":"Miller","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101783_bib110","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1021\/acschembio.0c00494","article-title":"An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties","volume":"15","author":"Mollasalehi","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib111","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1128\/MCB.01177-13","article-title":"Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity","volume":"34","author":"Morlino","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib112","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/sj.cdd.4400741","article-title":"The role of p53 in neuronal cell death","volume":"7","author":"Morrison","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101783_bib113","first-page":"CD012990","article-title":"GLP-1 receptor agonists for Parkinson's disease","volume":"7","author":"Mulvaney","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.arr.2022.101783_bib114","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13311-013-0182-9","article-title":"alpha-Synuclein and mitochondria: partners in crime?","volume":"10","author":"Nakamura","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2022.101783_bib115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/1028415X.2015.1135559","article-title":"Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells","volume":"20","author":"Nataraj","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib116","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jns.2017.11.039","article-title":"Scan without evidence of dopaminergic deficit (SWEDD) in degenerative parkinsonism and dementia with Lewy bodies: a prospective study","volume":"385","author":"Nicastro","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105543","article-title":"ABBV-0805, a novel antibody selective for soluble aggregated \u03b1-synuclein, prolongs lifespan and prevents buildup of \u03b1-synuclein pathology in mouse models of Parkinson's disease","volume":"161","author":"Nordstr\u00f6m","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib118","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.21277","article-title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update","volume":"31","author":"Nuytemans","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.arr.2022.101783_bib119","doi-asserted-by":"crossref","first-page":"jcs219469","DOI":"10.1242\/jcs.219469","article-title":"Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX","volume":"131","author":"Oeding","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2022.101783_bib120","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.201708122","article-title":"New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes","volume":"217","author":"Okumoto","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib121","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0079-6123(10)83007-9","article-title":"Role of post-translational modifications in modulating the structure, function and toxicity of \u03b1-synuclein: implications for Parkinson\u2019s disease pathogenesis and therapies","volume":"183","author":"Oueslati","year":"2010","journal-title":"Prog. Brain Res"},{"key":"10.1016\/j.arr.2022.101783_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101560","article-title":"A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities","volume":"75","author":"Panda","year":"2022","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2022.101783_bib123","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mito.2022.07.002","article-title":"The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches","volume":"66","author":"Panda","year":"2022","journal-title":"Mitochondrion"},{"key":"10.1016\/j.arr.2022.101783_bib124","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1007\/s11064-016-2034-6","article-title":"Curcumin monoglucoside shows improved bioavailability and mitigates rotenone induced neurotoxicity in cell and Drosophila models of Parkinson\u2019s disease","volume":"41","author":"Pandareesh","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2022.101783_bib125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1472-8206.2008.00609.x","article-title":"Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats","volume":"22","author":"Pari","year":"2008","journal-title":"Fundam. Clin. Pharm."},{"key":"10.1016\/j.arr.2022.101783_bib126","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000068505","article-title":"Mutation screening and association analysis of the parkin gene in Parkinson\u2019s disease patients from South-West China","volume":"49","author":"Peng","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib127","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1080\/21691401.2019.1636805","article-title":"Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson\u2019s disease via regulating miR-100\/ATG10 axis and PI3K\/Akt\/mTOR pathway activation","volume":"47","author":"Peng","year":"2019","journal-title":"Artif. Cells, Nanomed., Biotechnol."},{"key":"10.1016\/j.arr.2022.101783_bib128","first-page":"5","article-title":"Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons","author":"Pozzi","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.arr.2022.101783_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep39490","article-title":"An acridine derivative,[4, 5-bis {(N-carboxy methyl imidazolium) methyl} acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models","volume":"6","author":"Prasad","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101783_bib130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnmol.2019.00025","article-title":"Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis","volume":"12","author":"Prasad","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib131","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40478-020-01062-w","article-title":"PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation","volume":"8","author":"Quinn","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2022.101783_bib132","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/ptr.2708","article-title":"Thymoquinone protects dopaminergic neurons against MPP+ and rotenone","volume":"23","author":"Radad","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2022.101783_bib133","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fnins.2016.00570","article-title":"Calcium: alpha-synuclein interactions in alpha-synucleinopathies","volume":"10","author":"Rcom-H'cheo-Gauthier","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib134","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2174\/156802612805220020","article-title":"Parkinson's disease management. Part II-discovery of MAO-B inhibitors based on nitrogen heterocycles and analogues","volume":"12","author":"Reis","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.arr.2022.101783_bib135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamaneurol.2013.5489","article-title":"Lower motor neuron involvement in tar dna-binding protein of 43 kda\u2013related frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"71","author":"Riku","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2022.101783_bib136","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/biom11050718","article-title":"Alpha-synuclein and mitochondrial dysfunction in parkinson\u2019s disease: the emerging role of VDAC","volume":"11","author":"Risiglione","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2022.101783_bib137","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/emboj.2012.38","article-title":"Mitochondrial quality control: a matter of life and death for neurons","volume":"31","author":"Rugarli","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2022.101783_bib138","first-page":"3","article-title":"USP30 sets a trigger threshold for PINK1\u2013PARKIN amplification of mitochondrial ubiquitylation","author":"Rusilowicz-Jones","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.arr.2022.101783_bib139","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1523\/JNEUROSCI.5417-08.2009","article-title":"Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport","volume":"29","author":"Russo","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib140","unstructured":"Sabri, M.A., Saber-Ayad, M.M., 2020. Mao Inhibitors."},{"key":"10.1016\/j.arr.2022.101783_bib141","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnmol.2017.00082","article-title":"Post-translational modifications and protein quality control in motor neuron and polyglutamine diseases","volume":"10","author":"Sambataro","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib142","doi-asserted-by":"crossref","first-page":"20728","DOI":"10.1073\/pnas.0808953105","article-title":"Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase","volume":"105","author":"Saotome","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.arr.2022.101783_bib143","series-title":"Mitophagy","first-page":"9","article-title":"Induction of PINK1\/Parkin-mediated mitophagy","author":"Sato","year":"2017"},{"key":"10.1016\/j.arr.2022.101783_bib144","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijpharm.2010.09.035","article-title":"In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid","volume":"403","author":"Sato","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.arr.2022.101783_bib145","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/brainsci10040232","article-title":"Do post-translational modifications influence protein aggregation in neurodegenerative diseases: a systematic review","volume":"10","author":"Schaffert","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.arr.2022.101783_bib146","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41418-020-00706-7","article-title":"Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities","volume":"28","author":"Schmidt","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101783_bib147","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00441-018-2856-4","article-title":"The enteric nervous system in PD: gateway, bystander victim, or source of solutions","volume":"373","author":"Shannon","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.arr.2022.101783_bib148","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1083\/jcb.201312123","article-title":"Mitochondrial trafficking and anchoring in neurons: New insight and implications","volume":"204","author":"Sheng","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib149","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-7091-6284-2_2","article-title":"PARKIN as a pathogenic gene for autosomal recessive juvenile parkinsonism","author":"Shimizu","year":"2000","journal-title":"Adv. Res. Neurodegener."},{"key":"10.1016\/j.arr.2022.101783_bib150","first-page":"159","article-title":"Disease-modifying therapy for Parkinson's disease","volume":"69","author":"Shimura","year":"2017","journal-title":"Brain Nerve"},{"key":"10.1016\/j.arr.2022.101783_bib151","series-title":"Understanding PTMs in Neurodegenerative Diseases","first-page":"129","article-title":"Post-translational modifications in brain diseases: a future for biomarkers","author":"Silva-Costa","year":"2022"},{"key":"10.1016\/j.arr.2022.101783_bib152","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mds.25249","article-title":"The genetics of P arkinson's disease: progress and therapeutic implications","volume":"28","author":"Singleton","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2020.107656","article-title":"Insight into human Miro1\/2 domain organization based on the structure of its N-terminal GTPase","volume":"212","author":"Smith","year":"2020","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.arr.2022.101783_bib154","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/cells11081261","article-title":"GBA variants and parkinson disease: mechanisms and treatments","volume":"11","author":"Smith","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101783_bib155","doi-asserted-by":"crossref","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","article-title":"alpha-Synuclein in Parkinson's disease","volume":"2","author":"Stefanis","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101783_bib156","doi-asserted-by":"crossref","first-page":"15996","DOI":"10.1523\/JNEUROSCI.2068-15.2015","article-title":"Miro1 regulates activity-driven positioning of mitochondria within astrocytic processes apposed to synapses to regulate intracellular calcium signaling","volume":"35","author":"Stephen","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101783_bib157","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pneurobio.2010.05.002","article-title":"Heat shock proteins: cellular and molecular mechanisms in the central nervous system","volume":"92","author":"Stetler","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101783_bib158","first-page":"161","article-title":"Stem cell treatments for Parkinson\u2019s disease","author":"Stoker","year":"2018","journal-title":"Exon Publ."},{"key":"10.1016\/j.arr.2022.101783_bib159","series-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","author":"Stoker","year":"2018"},{"key":"10.1016\/j.arr.2022.101783_bib160","doi-asserted-by":"crossref","first-page":"23379","DOI":"10.1002\/jcp.28907","article-title":"MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model","volume":"234","author":"Sun","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.arr.2022.101783_bib161","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41419-018-1022-y","article-title":"Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2022.101783_bib162","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1111\/febs.14607","article-title":"Determinants of dopaminergic neuron loss in Parkinson's disease","volume":"285","author":"Surmeier","year":"2018","journal-title":"FEBS J."},{"issue":"797\u2013810","key":"10.1016\/j.arr.2022.101783_bib163","article-title":"AUTACs: cargo-specific degraders using selective autophagy","volume":"76","author":"Takahashi","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2022.101783_bib164","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1038\/s41598-018-24463-3","article-title":"Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals","volume":"8","author":"Tamaki","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101783_bib165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/antiox9010049","article-title":"Neuroprotective mechanisms of three natural antioxidants on a rat model of parkinson\u2019s disease: a comparative study","volume":"9","author":"Tancheva","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2022.101783_bib166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells5010001","article-title":"MIRO GTPases in mitochondrial transport, homeostasis and pathology","volume":"5","author":"Tang","year":"2015","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101783_bib167","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/jb\/mvp122","article-title":"Protein quality control in mitochondria","volume":"146","author":"Tatsuta","year":"2009","journal-title":"J. Biochem"},{"key":"10.1016\/j.arr.2022.101783_bib168","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1242\/dev.118.2.463","article-title":"trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues","volume":"118","author":"Tessarollo","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.arr.2022.101783_bib169","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12199-007-0019-4","article-title":"Selenium: its role as antioxidant in human health","volume":"13","author":"Tinggi","year":"2008","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.arr.2022.101783_bib170","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1139\/O09-167","article-title":"Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation","volume":"88","author":"Truscott","year":"2010","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib171","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00401-014-1259-1","article-title":"Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice","volume":"127","author":"Umeda","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2022.101783_bib172","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nbd.2012.05.015","article-title":"The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's disease","volume":"51","author":"Van Laar","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib173","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2022.101783_bib174","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/jnc.13655","article-title":"The mitochondrial kinase PINK 1: functions beyond mitophagy","volume":"139","author":"Voigt","year":"2016","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2022.101783_bib175","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.18632\/oncotarget.15511","article-title":"The long noncoding RNA HOTAIR promotes Parkinson\u2019s disease by upregulating LRRK2 expression","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.arr.2022.101783_bib176","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ijpharm.2018.08.043","article-title":"Protein aggregation\u2013mechanisms, detection, and control","volume":"550","author":"Wang","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.arr.2022.101783_bib177","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.biocel.2010.06.016","article-title":"TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases","volume":"42","author":"Warraich","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2022.101783_bib178","first-page":"267","article-title":"[Glutamate signaling and neural plasticity]","volume":"45","author":"Watanabe","year":"2013","journal-title":"No Hattatsu"},{"key":"10.1016\/j.arr.2022.101783_bib179","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.nbd.2018.10.016","article-title":"Development of an aggregate-selective, human-derived \u03b1-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models","volume":"124","author":"Weihofen","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101783_bib180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/mds.28858","article-title":"Parkinson's disease modification through Abl kinase inhibition: an opportunity","volume":"37","author":"Werner","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101783_bib181","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-170560","article-title":"Potential of low dose leuco-methylthioninium bis (hydromethanesulphonate)(LMTM) monotherapy for treatment of mild Alzheimer\u2019s disease: cohort analysis as modified primary outcome in a phase III clinical trial","volume":"61","author":"Wilcock","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2022.101783_bib182","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12035-018-1082-0","article-title":"Extracellular alpha-synuclein oligomers induce parkin s-nitrosylation: relevance to sporadic Parkinson\u2019s disease etiopathology","volume":"56","author":"Wilkaniec","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2022.101783_bib183","first-page":"147","article-title":"TDP-43 in aging and Alzheimer's disease - a review","volume":"4","author":"Wilson","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.arr.2022.101783_bib184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"\u03b1-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2022.101783_bib185","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1093\/brain\/aww238","article-title":"A de novo compound targeting \u03b1-synuclein improves deficits in models of Parkinson\u2019s disease","volume":"139","author":"Wrasidlo","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.arr.2022.101783_bib186","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12929-020-00636-z","article-title":"Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases","volume":"27","author":"Wu","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.arr.2022.101783_bib187","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2147\/NDT.S286778","article-title":"Long noncoding RNA SNHG1 knockdown ameliorates apoptosis, oxidative stress and inflammation in models of Parkinson\u2019s disease by inhibiting the miR-125b-5p\/MAPK1 Axis","volume":"17","author":"Xiao","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.arr.2022.101783_bib188","first-page":"2018","article-title":"LincRNA-p21 inhibits cell viability and promotes cell apoptosis in Parkinson\u2019s disease through activating-synuclein expression","author":"Xu","year":"2018","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.arr.2022.101783_bib189","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/iji.12549","article-title":"LncRNA MALAT1 potentiates inflammation disorder in Parkinson's disease","volume":"48","author":"Yang","year":"2021","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.arr.2022.101783_bib190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1053-4","article-title":"MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson\u2019s disease","volume":"15","author":"Yao","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2022.101783_bib191","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1177\/0963689717735411","article-title":"Cell therapy for Parkinson\u2019s disease","volume":"26","author":"Yasuhara","year":"2017","journal-title":"Cell Transpl."},{"key":"10.1016\/j.arr.2022.101783_bib192","first-page":"297","article-title":"The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation","author":"Yoast","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101783_bib193","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5483\/BMBRep.2022.55.7.073","article-title":"Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson\u2019s disease","volume":"55","author":"Yoo","year":"2022","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2022.101783_bib194","first-page":"66","article-title":"[Clinical and genetic analysis of juvenile parkinsonism in Russia]","volume":"104","author":"Zagorovskaia","year":"2004","journal-title":"Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova"},{"key":"10.1016\/j.arr.2022.101783_bib195","article-title":"Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2022.101783_bib196","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.4049\/jimmunol.1400653","article-title":"Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury","volume":"192","author":"Zhang","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2022.101783_bib197","doi-asserted-by":"crossref","first-page":"21138","DOI":"10.3390\/molecules201219753","article-title":"Antioxidant phytochemicals for the prevention and treatment of chronic diseases","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2022.101783_bib198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-016-0218-2","article-title":"Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson\u2019s disease (PD)","volume":"9","author":"Zhou","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.arr.2022.101783_bib199","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142296","article-title":"TDP-43 Inhibits NF-\u03baB Activity by blocking p65 nuclear translocation","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722002252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722002252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:03:05Z","timestamp":1761591785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163722002252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":199,"alternative-id":["S1568163722002252"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101783","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101783"}}