{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:45:47Z","timestamp":1786632347188,"version":"build-2736575974"},"reference-count":227,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.arr.2022.101841","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:55:49Z","timestamp":1672746949000},"page":"101841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Kinases control of regulated cell death revealing druggable targets for Parkinson\u2019s disease"],"prefix":"10.1016","volume":"85","author":[{"given":"Heba M.","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed F.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman S.","family":"El-Khatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud.M.","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2022.101841_bib1","article-title":"Inhibiting the DNA damage response pathway promotes functional recovery after spinal cord injury","volume":"2","author":"Ahmed","year":"2022","journal-title":"Clin. Transl. Discov."},{"key":"10.1016\/j.arr.2022.101841_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(02)00332-4","article-title":"An anti-Parkinson\u2019s disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells","volume":"326","author":"Akao","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101841_bib3","first-page":"1581","article-title":"Cell Death and Survival Pathways Involving ATM Protein Kinase","volume":"12","author":"Aki","year":"2021","journal-title":"Genes 2021"},{"key":"10.1016\/j.arr.2022.101841_bib4","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1093\/hmg\/ddp346","article-title":"LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model","volume":"18","author":"Alegre-Abarrategui","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.arr.2022.101841_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-079X.2005.00308.x","article-title":"Inhibition of the cdk5\/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson\u2019s disease","volume":"40","author":"Alvira","year":"2006","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.arr.2022.101841_bib6","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/jnr.21427","article-title":"Neuroprotective effects of caffeine against complex I inhibition\u2013induced apoptosis are mediated by inhibition of the Atm\/p53\/E2F-1 path in cerebellar granule neurons","volume":"85","author":"Alvira","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101841_bib7","doi-asserted-by":"crossref","first-page":"E5944","DOI":"10.1073\/pnas.1806973115","article-title":"Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF\u03b1-mediated apoptosis","volume":"115","author":"Amin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib8","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/humu.21582","article-title":"Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death","volume":"32","author":"Angeles","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.arr.2022.101841_bib9","first-page":"1","article-title":"A motif within the armadillo repeat of Parkinson\u2019s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway","author":"Antoniou","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2022.101841_bib10","doi-asserted-by":"crossref","first-page":"12842","DOI":"10.1074\/jbc.M608243200","article-title":"Phosphorylation of Parkin by the Cyclin-dependent Kinase 5 at the Linker Region Modulates Its Ubiquitin-Ligase Activity and Aggregation","volume":"282","author":"Avraham","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101841_bib11","first-page":"5","article-title":"The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis","author":"Bellizzi","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.arr.2022.101841_bib12","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1091\/mbc.E15-06-0415","article-title":"Peptide TFP5\/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson\u2019s disease","volume":"26","author":"Binukumar","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.arr.2022.101841_bib13","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1002\/elps.201200196","article-title":"Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury","volume":"33","author":"Boutt\u00e9","year":"2012","journal-title":"Electrophoresis"},{"key":"10.1016\/j.arr.2022.101841_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00018-012-1061-y","article-title":"The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK\/ERK pathway","volume":"70","author":"Bravo-San Pedro","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2022.101841_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pharmthera.2007.02.002","article-title":"Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease","volume":"114","author":"Burke","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ana.24410","article-title":"Syndromic parkinsonism and dementia associated with OPA1 missense mutations","volume":"78","author":"Carelli","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12665","article-title":"Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer\u2019s disease","volume":"69","author":"Chen","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.arr.2022.101841_bib18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41418-019-0393-7","article-title":"Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101841_bib19","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/bph.14653","article-title":"Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3","volume":"176","author":"Chen","year":"2019","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.arr.2022.101841_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1083\/jcb.201108059","article-title":"Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential","volume":"195","author":"Chen","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib21","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/sj.cdd.4402165","article-title":"Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells","volume":"14","author":"Chen","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101841_bib22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib23","first-page":"3","article-title":"A novel role for RIP1 kinase in mediating TNF\u03b1 production","author":"Christofferson","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2022.101841_bib24","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1093\/hmg\/ddu281","article-title":"Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival","volume":"23","author":"Chuang","year":"2014","journal-title":"Hum. Mol. Genet"},{"issue":"15","key":"10.1016\/j.arr.2022.101841_bib25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrd.2015.6","article-title":"Regulated necrosis: disease relevance and therapeutic opportunities","volume":"155","author":"Conrad","year":"2016","journal-title":"Nat. Rev. Drug Discov. 2016"},{"key":"10.1016\/j.arr.2022.101841_bib26","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bbadis.2016.05.022","article-title":"Mixed \u2013 Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states","volume":"1862","author":"Craige","year":"2016","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.arr.2022.101841_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/1673-5374.226394","article-title":"Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury","volume":"13","author":"Cruz","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2022.101841_bib28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.brainres.2010.11.095","article-title":"The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKC\u03b1\/PKC\u03b4 signaling","volume":"1398","author":"Cui","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2022.101841_bib29","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.2174\/138161209789649330","article-title":"Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions","volume":"15","author":"Cuny","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2022.101841_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib32","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1073\/pnas.1901179116","article-title":"Targeting RIPK1 for the treatment of human diseases","volume":"116","author":"Degterev","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.arr.2017.12.007","article-title":"The genetics of Parkinson disease","volume":"42","author":"Deng","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101841_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nchembio.538","article-title":"Characterization of a selective inhibitor of the Parkinson\u2019s disease kinase LRRK2","volume":"7","author":"Deng","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.14336\/AD.2018.0728","article-title":"Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3\/MLKL Signaling","volume":"10","author":"Deng","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2022.101841_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2013.5593","article-title":"Targeting Chelatable Iron as a Therapeutic Modality in Parkinson\u2019s Disease","volume":"21","author":"Devos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"10","key":"10.1016\/j.arr.2022.101841_bib37","first-page":"1","article-title":"Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson\u2019s disease","volume":"1011","author":"Dion\u00edsio","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2022.101841_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101263","article-title":"Oxidative stress and regulated cell death in Parkinson\u2019s disease","volume":"67","author":"Dion\u00edsio","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2022.101841_bib39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101841_bib40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib41","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","article-title":"MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates","volume":"7","author":"Dondelinger","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2022.101841_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0646-z","article-title":"The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-\u03b2 degradation","volume":"13","author":"Dong","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2022.101841_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","article-title":"The Parkinson Pandemic\u2014A Call to Action","volume":"75","author":"Dorsey","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib44","first-page":"7","article-title":"Parkinson\u2019s disease-implicated kinases in the brain; insights into disease pathogenesis","author":"Dzamko","year":"2014","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.arr.2022.101841_bib45","article-title":"A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis","volume":"65","author":"Fauster","year":"2015","journal-title":"Cell Death Dis. 2015"},{"key":"10.1016\/j.arr.2022.101841_bib46","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tcb.2015.03.003","article-title":"Surviving apoptosis: life-death signaling in single cells","volume":"25","author":"Flusberg","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib47","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2022.101841_bib48","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12033-007-0053-x","article-title":"ASK family proteins in stress response and disease","volume":"37","author":"Fujisawa","year":"2007","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.arr.2022.101841_bib50","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/15384101.2018.1442626","article-title":"Repurposing anticancer drugs for targeting necroptosis","volume":"17","author":"Fulda","year":"2018","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.arr.2022.101841_bib51","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrm906","article-title":"Mixed-lineage kinase control of JNK and p38 MAPK pathways","volume":"39","author":"Gallo","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol. 2002"},{"key":"10.1016\/j.arr.2022.101841_bib52","first-page":"207","article-title":"Therapeutic potential of targeting mixed lineage kinases in cancer and inflammation","author":"Gallo","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"25","key":"10.1016\/j.arr.2022.101841_bib53","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"253","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ. 2018"},{"key":"10.1016\/j.arr.2022.101841_bib54","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.arr.2022.101841_bib55","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2174\/15701611113116660153","article-title":"Endogenous events modulating myogenic regulation of cerebrovascular function","volume":"12","author":"Gebremedhin","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.arr.2022.101841_bib56","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jneumeth.2012.12.015","article-title":"ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?","volume":"214","author":"Gillardon","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.arr.2022.101841_bib57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/hmg\/ddi439","article-title":"The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity","volume":"15","author":"Gloeckner","year":"2006","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.arr.2022.101841_bib58","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.1471-4159.2007.05115.x","article-title":"6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA","volume":"104","author":"Gomez-Lazaro","year":"2008","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2022.101841_bib59","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1080\/15384101.2017.1371889","article-title":"Biological events and molecular signaling following MLKL activation during necroptosis","volume":"16","author":"Gong","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2022.101841_bib60","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/febs.13658","article-title":"The cell\u2019s dilemma, or the story of cell death: an entertainment in three acts","volume":"283","author":"Green","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.arr.2022.101841_bib61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2017.01.004","article-title":"Ferroptosis and cell death mechanisms in Parkinson\u2019s disease","volume":"104","author":"Guiney","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2022.101841_bib62","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1002\/elps.201200326","article-title":"In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system","volume":"33","author":"Guingab-Cagmat","year":"2012","journal-title":"Electrophoresis"},{"key":"10.1016\/j.arr.2022.101841_bib63","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/acs.jmedchem.6b01751","article-title":"Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment","volume":"60","author":"Harris","year":"2017","journal-title":"Inflamm. Dis. J. Med. Chem."},{"key":"10.1016\/j.arr.2022.101841_bib64","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1523\/JNEUROSCI.21-07-02247.2001","article-title":"Caspase-8 Is an Effector in Apoptotic Death of Dopaminergic Neurons in Parkinson\u2019s Disease, But Pathway Inhibition Results in Neuronal Necrosis","volume":"21","author":"Hartmann","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101841_bib65","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fnagi.2018.00162","article-title":"Cdk5 inhibitory peptide prevents loss of dopaminergic neurons and alleviates behavioral changes in an MPTP induced Parkinson\u2019s disease mouse model","volume":"10","author":"He","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2022.101841_bib66","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-\u03b1","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib67","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1474-4422(08)70117-0","article-title":"Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson\u2019s disease: a case-control study","volume":"7","author":"Healy","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib68","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.1408987111","article-title":"Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death","volume":"111","author":"Hildebrand","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib69","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","article-title":"DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2","volume":"287","author":"Hirao","year":"2000","journal-title":"Sci. (80-. )"},{"issue":"1","key":"10.1016\/j.arr.2022.101841_bib70","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd892","article-title":"The druggable genome","volume":"19","author":"Hopkins","year":"2002","journal-title":"Nat. Rev. Drug Discov. 2002"},{"issue":"3","key":"10.1016\/j.arr.2022.101841_bib71","first-page":"1","article-title":"ATM-associated signalling triggers the unfolded protein response and cell death in response to stress","volume":"31","author":"Hotokezaka","year":"2020","journal-title":"Commun. Biol. 2020"},{"key":"10.1016\/j.arr.2022.101841_bib72","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1523\/JNEUROSCI.4589-10.2011","article-title":"Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade","volume":"31","author":"Hu","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2022.101841_bib73","first-page":"10","article-title":"miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson\u2019s disease","author":"Hu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2022.101841_bib74","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ncb2058","article-title":"The role of Cdk5-mediated apurinic\/apyrimidinic endonuclease 1 phosphorylation in neuronal death","volume":"12","author":"Huang","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib75","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.molcel.2016.02.023","article-title":"Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate","volume":"61","author":"Hughes","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2022.101841_bib76","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1073\/pnas.0307453101","article-title":"JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson\u2019s disease","volume":"101","author":"Hunot","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib77","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.201303066","article-title":"JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis","volume":"202","author":"Huntwork-Rodriguez","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib78","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/j.celrep.2018.01.089","article-title":"Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson\u2019s Disease Models","volume":"22","author":"Iannielli","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2022.101841_bib79","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/antiox9100943","article-title":"Traumatic brain injury: oxidative stress and novel anti-oxidants such as mitoquinone and edaravone","volume":"9","author":"Ismail","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2022.101841_bib80","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1021\/bi061960m","article-title":"GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson\u2019s disease","volume":"46","author":"Ito","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2022.101841_bib81","first-page":"14","article-title":"Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson\u2019s disease","author":"Jennings","year":"2022","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.arr.2022.101841_bib82","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08229","article-title":"XIAP discriminates between type I and type II FAS-induced apoptosis","volume":"460","author":"Jost","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.arr.2022.101841_bib83","first-page":"2012","article-title":"At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology","author":"KA","year":"2012","journal-title":"Brain Disord. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib84","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2013.02.003","article-title":"Necroptosis: the release of damage-associated molecular patterns and its physiological relevance","volume":"38","author":"Kaczmarek","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2022.101841_bib85","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib86","first-page":"14","article-title":"LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia","author":"Kim","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101841_bib87","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.3390\/ijms20133131","article-title":"Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci. 2019"},{"key":"10.1016\/j.arr.2022.101841_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102072","article-title":"Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury","volume":"203","author":"Kim","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101841_bib89","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbamcr.2010.09.013","article-title":"Is mPTP the gatekeeper for necrosis, apoptosis, or both?","volume":"1813","author":"Kinnally","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2022.101841_bib90","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.expneurol.2019.05.002","article-title":"The second generation mixed lineage kinase-3 (MLK3) inhibitor CLFB-1134 protects against neurotoxin-induced nigral dopaminergic neuron loss","volume":"318","author":"Kline","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib91","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fneur.2016.00198","article-title":"Neuroproteomics and systems biology approach to identify temporal biomarker changes post experimental traumatic brain injury in rats","volume":"7","author":"Kobeissy","year":"2016","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib92","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.arr.2022.101841_bib93","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2022.101841_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102232","article-title":"Inactivation of RIP3 kinase sensitizes to 15LOX\/PEBP1-mediated ferroptotic death","volume":"50","author":"Lamade","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2022.101841_bib95","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1073\/pnas.1505244112","article-title":"A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis","volume":"112","author":"Li","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib96","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.arr.2022.101841_bib97","first-page":"1","article-title":"Ferroptosis: past, present and future","volume":"112","author":"Li","year":"2020","journal-title":"Cell Death Dis. 2020"},{"issue":"5","key":"10.1016\/j.arr.2022.101841_bib98","article-title":"The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury","volume":"56","author":"Li","year":"2014","journal-title":"Cell Death Dis. 2014"},{"key":"10.1016\/j.arr.2022.101841_bib99","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101841_bib100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107979","article-title":"Novel insights into RIPK1 as a promising target for future Alzheimer\u2019s disease treatment","volume":"231","author":"Li","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib102","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2018.07.044","article-title":"Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke","volume":"390","author":"Li","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101841_bib103","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2022.01.001","article-title":"Cannabinol inhibits oxytosis\/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors","volume":"180","author":"Liang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2022.101841_bib104","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41374-019-0319-5","article-title":"RIP1\/RIP3\/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease","volume":"100","author":"Lin","year":"2020","journal-title":"Lab. Invest."},{"key":"10.1016\/j.arr.2022.101841_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147310","article-title":"RIPK1 inhibitor ameliorates the MPP+\/MPTP-induced Parkinson\u2019s disease through the ASK1\/JNK signalling pathway","volume":"1757","author":"Liu","year":"2021","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2022.101841_bib106","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/cdd.2017.78","article-title":"RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice","volume":"24","author":"Liu","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2022.101841_bib107","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/jcbfm.2010.29","article-title":"Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation","volume":"30","author":"Lochhead","year":"2010","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.arr.2022.101841_bib108","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/WNF.0000000000000016","article-title":"Cannabis (Medical Marijuana) treatment for motor and non-motor symptoms of parkinson disease: An open-label observational study","volume":"37","author":"Lotan","year":"2014","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.arr.2022.101841_bib109","doi-asserted-by":"crossref","first-page":"268ra178","DOI":"10.1126\/scitranslmed.3010523","article-title":"Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington\u2019s disease","volume":"6","author":"Lu","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.arr.2022.101841_bib110","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12174","article-title":"RIP1-driven autoinflammation targets IL-1\u03b1 independently of inflammasomes and RIP3","author":"Lukens","year":"2013","journal-title":"Nat"},{"key":"10.1016\/j.arr.2022.101841_bib111","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.tcb.2016.07.002","article-title":"Physiological and Pharmacological Control of BAK, BAX, and Beyond","volume":"26","author":"Luna-Vargas","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib112","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/j.1471-4159.2005.03014.x","article-title":"Inhibition of microglial inflammation by the MLK inhibitor CEP-1347","volume":"92","author":"Lund","year":"2005","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2022.101841_bib113","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2022.101841_bib114","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101841_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113697","article-title":"Lapatinib ditosylate rescues memory impairment in D-galactose\/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer\u2019s disease","volume":"341","author":"Mansour","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105178","article-title":"Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer\u2019s-like disease in D-galactose\/ovariectomized rats","volume":"150","author":"Mansour","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2022.101841_bib117","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2021.06.013","article-title":"Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer\u2019s Disease: Current Perspectives and Challenging Prospects","volume":"469","author":"Mansour","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2022.101841_bib118","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4103\/1673-5374.332132","article-title":"Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer\u2019s disease","volume":"17","author":"Mansour","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2022.101841_bib119","doi-asserted-by":"crossref","first-page":"9998","DOI":"10.1523\/JNEUROSCI.0598-13.2013","article-title":"The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders","volume":"33","author":"Marker","year":"2013","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.arr.2022.101841_bib120","first-page":"1","article-title":"RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)","volume":"92","author":"Martens","year":"2018","journal-title":"Cell Death Dis. 2018"},{"issue":"73","key":"10.1016\/j.arr.2022.101841_bib121","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00018-016-2130-4","article-title":"The DNA damage-induced cell death response: a roadmap to kill cancer cells","volume":"7315","author":"Matt","year":"2016","journal-title":"Cell. Mol. Life Sci. 2016"},{"key":"10.1016\/j.arr.2022.101841_bib122","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1007\/s11064-016-1982-1","article-title":"Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson\u2019s Disease","volume":"41","author":"Mendivil-Perez","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.arr.2022.101841_bib123","doi-asserted-by":"crossref","first-page":"E2001","DOI":"10.1073\/pnas.1722013115","article-title":"Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis","volume":"115","author":"Meng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib124","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1523\/JNEUROSCI.4368-13.2014","article-title":"Ischemic stroke injury is mediated by aberrant Cdk5","volume":"34","author":"Meyer","year":"2014","journal-title":"J. Neurosci."},{"issue":"19","key":"10.1016\/j.arr.2022.101841_bib125","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41573-020-0071-y","article-title":"Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target","volume":"198","author":"Mifflin","year":"2020","journal-title":"Nat. Rev. Drug Discov. 2020"},{"key":"10.1016\/j.arr.2022.101841_bib126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10072-013-1477-7","article-title":"Functional recovery and alterations in the expression and localization of protein kinase C following voluntary exercise in rat with cerebral infarction","volume":"35","author":"Mizutani","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib127","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(94)90746-3","article-title":"Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients","volume":"165","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.arr.2022.101841_bib128","first-page":"1","article-title":"Current translational potential and underlying molecular mechanisms of necroptosis","volume":"1011","author":"Moln\u00e1r","year":"2019","journal-title":"Cell Death Dis. 2019"},{"key":"10.1016\/j.arr.2022.101841_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076841","article-title":"CYLD Deubiquitinates RIP1 in the TNF\u03b1-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis","volume":"8","author":"Moquin","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.arr.2022.101841_bib130","first-page":"1","article-title":"Necroptosis mediates myofibre death in dystrophin-deficient mice","volume":"91","author":"Morgan","year":"2018","journal-title":"Nat. Commun. 2018"},{"key":"10.1016\/j.arr.2022.101841_bib131","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/B978-0-12-397918-6.00003-3","article-title":"Fragment-based approaches to the discovery of kinase inhibitors","volume":"548","author":"Mortenson","year":"2014","journal-title":"Methods Enzym."},{"key":"10.1016\/j.arr.2022.101841_bib132","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0960-894X(01)00690-4","article-title":"Mixed lineage kinase activity of indolocarbazole analogues","volume":"12","author":"Murakata","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.arr.2022.101841_bib133","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2022.101841_bib134","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2174\/1381612822666151124235028","article-title":"Neuroprotective Mechanisms Mediated by CDK5 Inhibition","volume":"22","author":"Mushtaq","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2022.101841_bib135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jns.2009.02.375","article-title":"Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson\u2019s disease","volume":"281","author":"Nagao","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib136","doi-asserted-by":"crossref","first-page":"13858","DOI":"10.3390\/ijms140713858","article-title":"Death Associated Protein Kinases: Molecular Structure and Brain Injury","volume":"14","author":"Nair","year":"2013","journal-title":"Int. J. Mol. Sci. 2013"},{"issue":"11","key":"10.1016\/j.arr.2022.101841_bib137","first-page":"955","article-title":"Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson\u2019s disease","volume":"116","author":"Nair","year":"2006","journal-title":"Apoptosis 2006"},{"key":"10.1016\/j.arr.2022.101841_bib138","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.celrep.2015.02.052","article-title":"Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1","volume":"10","author":"Najjar","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2022.101841_bib139","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1249361","article-title":"Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis","volume":"343","author":"Newton","year":"2014","journal-title":"Sci. (80-. )"},{"key":"10.1016\/j.arr.2022.101841_bib140","doi-asserted-by":"crossref","first-page":"37033","DOI":"10.1074\/jbc.M506771200","article-title":"Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death","volume":"280","author":"Noguchi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2022.101841_bib141","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pneurobio.2018.01.003","article-title":"Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms","volume":"165\u2013167","author":"Nokkari","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2022.101841_bib142","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cub.2007.01.027","article-title":"Ubiquitination of RIP1 regulates an NF-\u03baB-independent cell death switch in TNF signaling","volume":"17","author":"O\u2019Donnell","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib143","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1101\/gad.276725.115","article-title":"Inactivation of prosurvival Bcl-2 proteins activates Bax\/Bak through the outer mitochondrial membrane","volume":"30","author":"O\u2019neill","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.arr.2022.101841_bib144","doi-asserted-by":"crossref","first-page":"13395","DOI":"10.3390\/ijms222413395","article-title":"Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions","volume":"22","author":"Obsilova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib145","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)00073-8","article-title":"p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53","volume":"102","author":"Oda","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib146","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jnc.13750","article-title":"Current and experimental treatments of Parkinson disease: A guide for neuroscientists","volume":"139","author":"Oertel","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2022.101841_bib147","first-page":"22","article-title":"Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice","author":"Oliveira","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"27","key":"10.1016\/j.arr.2022.101841_bib148","first-page":"1169","article-title":"The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease","volume":"274","author":"O\u00f1ate","year":"2019","journal-title":"Cell Death Differ. 2019"},{"issue":"21","key":"10.1016\/j.arr.2022.101841_bib149","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/cdd.2014.76","article-title":"RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis","volume":"2110","author":"Orozco","year":"2014","journal-title":"Cell Death Differ. 2014"},{"key":"10.1016\/j.arr.2022.101841_bib150","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbrc.2007.08.006","article-title":"Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling","volume":"362","author":"Ortner","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2022.101841_bib151","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pscychresns.2018.03.004","article-title":"Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms","volume":"275","author":"Owens-Walton","year":"2018","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.arr.2022.101841_bib152","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1124\/mol.107.038463","article-title":"K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3\/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1\/JNK3 signaling pathways","volume":"72","author":"Pan","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"50","key":"10.1016\/j.arr.2022.101841_bib153","first-page":"1","article-title":"HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis","volume":"509","author":"Park","year":"2018","journal-title":"Exp. Mol. Med. 2018"},{"key":"10.1016\/j.arr.2022.101841_bib154","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1001\/archneur.1969.00480100117017","article-title":"An essay on the shaking palsy","volume":"20","author":"Parkinson","year":"1969","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib155","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1021\/acs.jmedchem.7b00843","article-title":"Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer\u2019s Disease","volume":"60","author":"Patel","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.arr.2022.101841_bib156","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/45159","article-title":"Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration","volume":"402","author":"Patrick","year":"1999","journal-title":"Nat"},{"key":"10.1016\/j.arr.2022.101841_bib157","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1097\/00004872-200207000-00022","article-title":"Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats","volume":"20","author":"Payne","year":"2002","journal-title":"J. Hypertens."},{"key":"10.1016\/j.arr.2022.101841_bib158","doi-asserted-by":"crossref","unstructured":"Perier, C., Bov\u00e9, J., Vila, M., 2012b, Mitochondria and Programmed Cell Death in Parkinson\u2019s Disease: Apoptosis and Beyond. https:\/\/home.liebertpub.com\/ars 16, 883\u2013895. https:\/\/doi.org\/10.1089\/ARS.2011.4074.","DOI":"10.1089\/ars.2011.4074"},{"key":"10.1016\/j.arr.2022.101841_bib159","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1089\/ars.2011.4074","article-title":"Mitochondria and programmed cell death in Parkinson\u2019s disease: apoptosis and beyond","volume":"16","author":"Perier","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2022.101841_bib160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2007.05.033","article-title":"Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson\u2019s disease","volume":"55","author":"Qu","year":"2007","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.arr.2022.101841_bib161","first-page":"1","article-title":"Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients","volume":"61","author":"Ren","year":"2016","journal-title":"Sci. Rep. 2016"},{"key":"10.1016\/j.arr.2022.101841_bib162","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/mol.110.063727","article-title":"Identification of RanBP 9\/10 as interacting partners for protein kinase C (PKC) gamma\/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation","volume":"78","author":"Rex","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.arr.2022.101841_bib163","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3389\/fnins.2020.00865","article-title":"The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson\u2019s Disease","volume":"14","author":"Rideout","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2022.101841_bib164","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.physiol.70.021507.105852","article-title":"Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis","volume":"70","author":"Rong","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.arr.2022.101841_bib165","first-page":"175","article-title":"Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update","author":"Roskoski","year":"2022","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.arr.2022.101841_bib166","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/2319-4170.104408","article-title":"Alarmins, inflammasomes and immunity","volume":"35","author":"Sa\u00efd-Sadier","year":"2012","journal-title":"Biomed. J."},{"key":"10.1016\/j.arr.2022.101841_bib167","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","article-title":"Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2022.101841_bib168","first-page":"35","article-title":"ATM mediated DNA double-strand breaks accumulate in LRRK2 G2019S Parkinson\u2019s disease","author":"Sanders","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101841_bib169","first-page":"288","article-title":"CEP-1347\/KT-7515, an Inhibitor of c-jun N-Terminal Kinase Activation, Attenuates the 1-Methyl-4-Phenyl Tetrahydropyridine-Mediated Loss of Nigrostriatal Dopaminergic Neurons In Vivo","author":"Saporito","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib170","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1046\/j.1471-4159.2000.0751200.x","article-title":"MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo","volume":"75","author":"Saporito","year":"2000","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2022.101841_bib171","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101841_bib172","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/156652406775574541","article-title":"The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases","volume":"6","author":"Sekine","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.arr.2022.101841_bib173","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.bmcl.2018.05.007","article-title":"Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery","volume":"28","author":"Shi","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.arr.2022.101841_bib174","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1212\/01.wnl.0000277648.63931.c0","article-title":"Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease","volume":"69","author":"Shoulson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2022.101841_bib175","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1212\/01.wnl.0000324506.93877.5e","article-title":"Mixed lineage kinase inhibitor CEP- 1347 fails to delay disability in early Parkinson disease","volume":"71","author":"Shoulson","year":"2008","journal-title":"Neurology"},{"issue":"23","key":"10.1016\/j.arr.2022.101841_bib176","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/cdd.2016.51","article-title":"K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo","volume":"2310","author":"Shutinoski","year":"2016","journal-title":"Cell Death Differ. 2016"},{"key":"10.1016\/j.arr.2022.101841_bib177","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.3206","article-title":"The diverse role of RIP kinases in necroptosis and inflammation","volume":"16","author":"Silke","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2022.101841_bib178","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/mds.20390","article-title":"Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson\u2019s disease","volume":"20","author":"Silva","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2022.101841_bib179","doi-asserted-by":"crossref","first-page":"13650","DOI":"10.1073\/pnas.2232515100","article-title":"Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson\u2019s disease","volume":"100","author":"Smith","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib180","doi-asserted-by":"crossref","first-page":"18676","DOI":"10.1073\/pnas.0508052102","article-title":"Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration","volume":"102","author":"Smith","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib181","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0304-3940(92)90355-B","article-title":"Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson\u2019s disease","volume":"142","author":"Sofic","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2022.101841_bib182","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1096\/fj.02-0216fje","article-title":"Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson\u2019s disease","volume":"16","author":"Sriram","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2022.101841_bib183","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1038\/jcbfm.2013.151","article-title":"PKC-\u03b2 exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA\/Rho-kinase\/MLC2 pathway","volume":"33","author":"Srivastava","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.arr.2022.101841_bib184","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.biopsych.2018.12.008","article-title":"MicroRNA-26a\/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson\u2019s Disease","volume":"85","author":"Su","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2022.101841_bib185","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.arr.2022.101841_bib186","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"119","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol. 2010"},{"key":"10.1016\/j.arr.2022.101841_bib187","first-page":"3","article-title":"Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models","author":"Takahashi","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2022.101841_bib188","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncb1829","article-title":"Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death","volume":"11","author":"Tian","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2022.101841_bib189","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.it.2016.06.002","article-title":"More to Life than NF-\u03baB in TNFR1 Signaling","volume":"37","author":"Ting","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.arr.2022.101841_bib190","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.expneurol.2019.04.013","article-title":"Roscovitine, an experimental CDK5 inhibitor, causes delayed suppression of microglial, but not astroglial recruitment around intracerebral dopaminergic grafts","volume":"318","author":"Tomov","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2022.101841_bib191","doi-asserted-by":"crossref","unstructured":"Tripathi, A., Kumar, P., 2021, Identification of Putative LRRK2 Inhibitors in the Pathogensis of Parkinson\u2019s Disease: A Drug-Repurposing Approach. 2021 5th Int. Conf. Inf. Syst. Comput. Networks, ISCON 2021. \u3008https:\/\/doi.org\/10.1109\/ISCON52037.2021.9702406\u3009.","DOI":"10.1109\/ISCON52037.2021.9702406"},{"key":"10.1016\/j.arr.2022.101841_bib192","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/mp.2017.171","article-title":"Tau-mediated iron export prevents ferroptotic damage after ischemic stroke","volume":"22","author":"Tuo","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2022.101841_bib193","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2022.101841_bib194","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1476-5381.2012.01859.x","article-title":"A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets","volume":"166","author":"Uitdehaag","year":"2012","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.arr.2022.101841_bib195","doi-asserted-by":"crossref","first-page":"a009365","DOI":"10.1101\/cshperspect.a009365","article-title":"Programmed Cell Death in Parkinson\u2019s Disease","volume":"2","author":"Venderova","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.arr.2022.101841_bib196","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","article-title":"Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease","volume":"98","author":"Vila","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib197","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1111\/cts.13317","article-title":"Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I\/Ib studies in healthy subjects and patients","volume":"15","author":"Vissers","year":"2022","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib198","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/glia.20732","article-title":"Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression via a p42\/p44 and JNK-dependent AP-1 pathway in brain astrocytes","volume":"57","author":"Wang","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.arr.2022.101841_bib199","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.622","article-title":"Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury","volume":"8","author":"Wang","year":"2021","journal-title":"Acute Med. Surg."},{"key":"10.1016\/j.arr.2022.101841_bib200","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","article-title":"The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib201","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066226","article-title":"Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction","volume":"8","author":"Watterson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101841_bib202","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tips.2016.12.005","article-title":"Complex pathologic roles of RIPK1 and RIPK3: moving beyond necroptosis","volume":"38","author":"Wegner","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.arr.2022.101841_bib203","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neures.2022.04.003","article-title":"cPKC\u03b3 ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation\/reoxygenation by inhibiting ferroptosis","volume":"181","author":"Wei","year":"2022","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101841_bib204","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/cpt.1852","article-title":"Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study","volume":"108","author":"Weisel","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib205","first-page":"23","article-title":"A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis","author":"Weisel","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.arr.2022.101841_bib206","first-page":"8","article-title":"A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis","author":"Weisel","year":"2021","journal-title":"BMJ Open Gastroenterol."},{"key":"10.1016\/j.arr.2022.101841_bib207","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.1403477111","article-title":"Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death","volume":"111","author":"Weng","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2022.101841_bib208","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/jnr.21240","article-title":"MAPK-pathway activity, Lrrk2 G2019S, and Parkinson\u2019s disease","volume":"85","author":"White","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2022.101841_bib209","first-page":"9","article-title":"PC12 cell line: cell types, coating of culture vessels, differentiation and other culture conditions","author":"Wiatrak","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2022.101841_bib210","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.200708086","article-title":"Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons","volume":"179","author":"Wright","year":"2007","journal-title":"J. Cell Biol."},{"issue":"23","key":"10.1016\/j.arr.2022.101841_bib211","first-page":"994","article-title":"Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis","volume":"238","author":"Wu","year":"2013","journal-title":"Cell Res. 2013"},{"key":"10.1016\/j.arr.2022.101841_bib212","article-title":"Targeting LRRK2 in Parkinson\u2019s disease","volume":"3","author":"Xiao","year":"2022","journal-title":"Cell Rep. Med"},{"key":"10.1016\/j.arr.2022.101841_bib213","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib214","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/MCB.21.14.4713-4724.2001","article-title":"The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis","volume":"21","author":"Xu","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2022.101841_bib215","article-title":"Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson\u2019s disease. npj Park. Dis. 2022 81 8","author":"Yan","year":"2022","journal-title":"1\u201312"},{"issue":"11","key":"10.1016\/j.arr.2022.101841_bib216","first-page":"1","article-title":"Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP+-induced apoptosis via suppression of ASK1-P38-NF-\u03baB pathway in SH-SY5Y cells","volume":"111","author":"Yang","year":"2021","journal-title":"Sci. Rep. 2021"},{"key":"10.1016\/j.arr.2022.101841_bib217","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.arr.2022.101841_bib218","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41556-017-0022-y","article-title":"RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis","volume":"202","author":"Yang","year":"2018","journal-title":"Nat. Cell Biol. 2018"},{"key":"10.1016\/j.arr.2022.101841_bib219","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.bbamcr.2017.09.001","article-title":"LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death","volume":"1864","author":"Yoon","year":"2017","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res"},{"key":"10.1016\/j.arr.2022.101841_bib220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41583-018-0093-1","article-title":"Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases","volume":"20","author":"Yuan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2022.101841_bib221","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.arr.2022.101841_bib222","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neurobiolaging.2019.09.012","article-title":"Apoptosis signal regulating kinase 1 deletion mitigates \u03b1-synuclein pre-formed fibril propagation in mice","volume":"85","author":"Zhang","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2022.101841_bib223","article-title":"Human Traumatic Brain Injury Induces Autoantibody Response against Glial Fibrillary Acidic Protein and Its Breakdown Products","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2022.101841_bib224","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105049","article-title":"LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation","volume":"144","author":"Zhao","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2022.101841_bib225","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cell.2014.06.041","article-title":"SnapShot: Necroptosis","volume":"158","author":"Zhou","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2022.101841_bib226","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146493","article-title":"Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson\u2019s disease model mice","volume":"1726","author":"Zhu","year":"2020","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2022.101841_bib227","first-page":"2","article-title":"Necrostatin-1 ameliorates symptoms in R6\/2 transgenic mouse model of Huntington\u2019s disease","author":"Zhu","year":"2011","journal-title":"Cell Death Dis."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722002835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163722002835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:05:54Z","timestamp":1761591954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163722002835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":227,"alternative-id":["S1568163722002835"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2022.101841","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinases control of regulated cell death revealing druggable targets for Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2022.101841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101841"}}