{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:58:30Z","timestamp":1793066310671,"version":"4.5.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31571195"],"award-info":[{"award-number":["NSFC31571195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82003702"],"award-info":[{"award-number":["NSFC82003702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.arr.2023.101961","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T12:01:09Z","timestamp":1684929669000},"page":"101961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Ferroportin1 in the brain"],"prefix":"10.1016","volume":"88","author":[{"given":"Zhong-Ming","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2023.101961_bib1","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","article-title":"A novel mammalian iron-regulated protein involved in intracellular iron metabolism","volume":"275","author":"Abboud","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2023.101961_bib2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1182\/blood-2017-05-786590","article-title":"Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin","volume":"131","author":"Aschemeyer","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.arr.2023.101961_bib3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3945\/jn.108.094052","article-title":"Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages","volume":"139","author":"Aydemir","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.arr.2023.101961_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2012.10.558","article-title":"Metallostasis in Alzheimer's disease","volume":"62","author":"Ayton","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2023.101961_bib5","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.chembiol.2017.10.002","article-title":"Nanoscale imaging reveals big role for iron in Alzheimer's disease","volume":"24","author":"Ayton","year":"2017","journal-title":"Cell. Chem. Biol."},{"key":"10.1016\/j.arr.2023.101961_bib6","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2023.101961_bib7","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1126\/science.1107224","article-title":"Cell biology. \"Pumping\" iron: the proteins","volume":"306","author":"Beutler","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.101961_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-020-2668-z","article-title":"Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms","volume":"586","author":"Billesb\u00f8lle","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101961_bib9","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0140-6736(96)91094-6","article-title":"Pumping iron in Parkinson's disease","volume":"347","author":"Bonn","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2023.101961_bib10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4103\/1673-5374.324847","article-title":"Iron, the endolysosomal system and neuroinflammation: a matter of balance","volume":"17","author":"Borquez","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2023.101961_bib11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10534-010-9405-2","article-title":"Heterogenous distribution of ferroportin-containing neurons in mouse brain","volume":"24","author":"Boserup","year":"2011","journal-title":"Biometals"},{"key":"10.1016\/j.arr.2023.101961_bib12","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jnr.1256","article-title":"Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat","volume":"66","author":"Burdo","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2023.101961_bib13","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1007\/s12035-015-9582-7","article-title":"Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier","volume":"53","author":"Burkhart","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2023.101961_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81332","article-title":"A crosstalk between hepcidin and IRE\/IRP pathways controls ferroportin expression and determines serum iron levels in mice","volume":"11","author":"Charlebois","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.arr.2023.101961_bib15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/19336896.2021.1946377","article-title":"Upregulation of brain hepcidin in prion diseases","volume":"15","author":"Chaudhary","year":"2021","journal-title":"Prion"},{"key":"10.1016\/j.arr.2023.101961_bib16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3233\/JAD-210221","article-title":"Upregulation of local hepcidin contributes to iron accumulation in Alzheimer's disease brains","volume":"82","author":"Chaudhary","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2023.101961_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharep.2016.09.011","article-title":"Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells","volume":"69","author":"Chen","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.arr.2023.101961_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neuint.2005.06.004","article-title":"Iron loading inhibits ferroportin1 expression in PC12 cells","volume":"47","author":"Chen","year":"2005","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2023.101961_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134684","article-title":"Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor","volume":"716","author":"Chen","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2023.101961_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jns.2006.04.008","article-title":"Is ferroportin-hepcidin signaling altered in restless legs syndrome?","volume":"247","author":"Clardy","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2023.101961_bib21","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.WNL.0000123251.60485.AC","article-title":"Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome","volume":"62","author":"Connor","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2023.101961_bib22","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/brain\/awr012","article-title":"Profile of altered brain iron acquisition in restless legs syndrome","volume":"134","author":"Connor","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.arr.2023.101961_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng571","article-title":"Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease","volume":"28","author":"Curtis","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2023.101961_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/BJ20071474","article-title":"Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression","volume":"411","author":"Delaby","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2023.101961_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.freeradbiomed.2015.05.025","article-title":"Role of extracellular Hydrogen peroxide in regulation of iron homeostasis genes in neuronal cells: Implication in iron accumulation","volume":"86","author":"Dev","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2023.101961_bib26","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3892\/etm.2015.2234","article-title":"Neuroprotective effect of the active components of three Chinese herbs on brain iron load in a mouse model of Alzheimer's disease","volume":"9","author":"Dong","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.arr.2023.101961_bib27","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101961_bib28","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jnutbio.2011.12.002","article-title":"The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells","volume":"23","author":"Du","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.arr.2023.101961_bib29","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cell.2010.08.014","article-title":"Iron-export ferroxidase activity of \u03b2-amyloid precursor protein is inhibited by zinc in Alzheimer's disease","volume":"142","author":"Duce","year":"2010","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.arr.2023.101961_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2017.10.083","article-title":"Regulatory mechanisms for iron transport across the blood-brain barrier","volume":"494","author":"Duck","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2023.101961_bib31","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1073\/pnas.92.21.9603","article-title":"Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease","volume":"92","author":"Faucheux","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2023.101961_bib32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI13739","article-title":"Ferroportin mutation in autosomal dominant hemochromatosis: loss of function, gain in understanding","volume":"108","author":"Fleming","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2023.101961_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cmet.2007.10.006","article-title":"Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum","volume":"7","author":"Galy","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2023.101961_bib34","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2023.101961_bib35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.expneurol.2013.10.013","article-title":"Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells","volume":"250","author":"Garrido-Gil","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2023.101961_bib36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jnutbio.2008.07.014","article-title":"The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes","volume":"20","author":"Ge","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.arr.2023.101961_bib37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.kint.2021.10.036","article-title":"Enteral ferric citrate absorption is dependent on theirontransportproteinferroportin","volume":"101","author":"Hanudel","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.arr.2023.101961_bib38","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/aww022","article-title":"Iron and dopamine: a toxic couple","volume":"139","author":"Hare","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.arr.2023.101961_bib39","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1073\/pnas.92.7.2539","article-title":"Aceruloplasminemia: molecular characterization of this disorder of iron metabolism","volume":"92","author":"Harris","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.arr.2023.101961_bib40","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1073\/pnas.93.16.8175","article-title":"Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress","volume":"93","author":"Hentze","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2023.101961_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of Mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101961_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2017.10.001","article-title":"Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK\/STAT3 pathway in interleukin 6-treated PC-12 cells","volume":"662","author":"Huang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2023.101961_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0962-8924(96)10019-2","article-title":"Pumping iron in the '90s","volume":"6","author":"Jefferies","year":"1996","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2023.101961_bib44","doi-asserted-by":"crossref","first-page":"27144","DOI":"10.1074\/jbc.M301988200","article-title":"Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system","volume":"278","author":"Jeong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2023.101961_bib45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000065687","article-title":"Distribution of ferroportin1 protein in different regions of developing rat brain","volume":"24","author":"Jiang","year":"2002","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib46","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(03)00353-3","article-title":"Iron misregulation in the brain: a primary cause of neurodegenerative disorders","volume":"2","author":"Ke","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2023.101961_bib47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2007.07.009","article-title":"Brain iron metabolism: neurobiology and neurochemistry","volume":"83","author":"Ke","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2023.101961_bib48","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/j.1460-2075.1995.tb00091.x","article-title":"A novel iron uptake mechanism mediated by GPI-anchored human p97","volume":"14","author":"Kennard","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2023.101961_bib49","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/nm1196-1230","article-title":"Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease","volume":"2","author":"Kennard","year":"1996","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.arr.2023.101961_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(93)90046-S","article-title":"Regulating the fate of mRNA: the control of cellular iron metabolism","volume":"72","author":"Klausner","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101961_bib51","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1182\/blood-2003-04-1250","article-title":"Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages","volume":"102","author":"Knutson","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.arr.2023.101961_bib52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00401-007-0220-y","article-title":"The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins","volume":"114","author":"Koeppen","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2023.101961_bib53","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41419-019-1854-0","article-title":"Ferroportin downregulation promotes cell proliferation by modulating the Nrf2-miR-17-5p axis in multiple myeloma","volume":"10","author":"Kong","year":"2019","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2023.101961_bib54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.2613","article-title":"Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export","volume":"18","author":"Lei","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2023.101961_bib55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s004010050468","article-title":"Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases","volume":"91","author":"Leveugle","year":"1996","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2023.101961_bib56","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mds.27381","article-title":"Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes","volume":"33","author":"Lewis","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2023.101961_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/med.10008","article-title":"Transferrin\/transferrin receptor-mediated drug delivery","volume":"22","author":"Li","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2023.101961_bib58","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jocn.2009.01.020","article-title":"Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia","volume":"16","author":"Li","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib59","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s12011-011-8967-3","article-title":"Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus","volume":"143","author":"Li","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.arr.2023.101961_bib60","article-title":"Hepatocyte growth factor protects PC12 cells against OGD\/R-induced injury by reducing iron","volume":"40","author":"Li","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.arr.2023.101961_bib61","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.3390\/ijms17121921","article-title":"Aspirin down regulates hepcidin by inhibiting NF-\u03baB and IL6\/JAK2\/STAT3 pathways in BV-2 microglial cells treated with lipopolysaccharide","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101961_bib62","doi-asserted-by":"crossref","first-page":"16334","DOI":"10.1523\/JNEUROSCI.0708-13.2013","article-title":"Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron","volume":"33","author":"Lieblein-Boff","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib63","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1007\/s12035-016-0067-0","article-title":"Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats","volume":"54","author":"Lu","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2023.101961_bib64","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00408-2","article-title":"The role of the iron responsive element in the control of ferroportin1\/IREG1\/MTP1 gene expression","volume":"39","author":"Lymboussaki","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.arr.2023.101961_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101865","article-title":"Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice","volume":"40","author":"Ma","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2023.101961_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101896","article-title":"Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies","volume":"41","author":"Ma","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2023.101961_bib67","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3324\/haematol.2009.020123","article-title":"Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE\/ARE sequence motif at position -7007 of the FPN1 promoter","volume":"95","author":"Marro","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.arr.2023.101961_bib68","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1073\/pnas.1519473113","article-title":"Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice","volume":"113","author":"Matak","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2023.101961_bib69","doi-asserted-by":"crossref","first-page":"809","DOI":"10.15252\/embr.201338064","article-title":"sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin","volume":"15","author":"McCarthy","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2023.101961_bib70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2023.101961_bib71","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-genom-090314-025011","article-title":"Neurodegeneration with brain iron accumulation: genetic diversity and pathophysiological mechanisms","volume":"16","author":"Meyer","year":"2015","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.arr.2023.101961_bib72","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1523\/JNEUROSCI.0900-21.2021","article-title":"Schwann cells provide iron to axonal mitochondria and its role in nerve regeneration","volume":"41","author":"Mietto","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib73","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200113468","article-title":"Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene","volume":"108","author":"Montosi","year":"2001","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.101961_bib74","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.spen.2006.08.003","article-title":"Ferroportin in the postnatal rat brain: implications for axonal transport and neuronal export of iron","volume":"13","author":"Moos","year":"2006","journal-title":"Semin. Pediatr. Neurol."},{"key":"10.1016\/j.arr.2023.101961_bib75","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.101961_bib76","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/90038","article-title":"A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis","volume":"28","author":"Njajou","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2023.101961_bib77","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/biof.84","article-title":"Regulatory mechanisms of intestinal iron absorption-uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis","volume":"36","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.arr.2023.101961_bib78","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10571-019-00694-4","article-title":"Fractalkine induces hepcidin expression of BV-2 microglia and causes iron accumulation in SH-SY5Y cells","volume":"39","author":"Pandur","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.arr.2023.101961_bib79","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neulet.2004.04.005","article-title":"Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis","volume":"363","author":"di Patti","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2023.101961_bib80","doi-asserted-by":"crossref","first-page":"12442","DOI":"10.3390\/ijms222212442","article-title":"Iron homeostasis disorder and Alzheimer's disease","volume":"22","author":"Peng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101961_bib81","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.nbd.2015.08.007","article-title":"The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin","volume":"81","author":"Peters","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2023.101961_bib82","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.nbd.2010.04.009","article-title":"Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation","volume":"39","author":"Poli","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2023.101961_bib83","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fphar.2014.00086","article-title":"Hepcidin antagonists for potential treatments of disorders with hepcidin excess","volume":"5","author":"Poli","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2023.101961_bib84","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/glia.23335","article-title":"Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease","volume":"66","author":"Puy","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.arr.2023.101961_bib85","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0165-0173(01)00056-X","article-title":"Rethinking the role of ceruloplasmin in brain iron metabolism","volume":"35","author":"Qian","year":"2001","journal-title":"Brain Res. Rev."},{"issue":"5","key":"10.1016\/j.arr.2023.101961_bib86","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/brv.12521","article-title":"Brain iron transport","volume":"94","author":"Qian","year":"2019","journal-title":"Biol. Rev."},{"issue":"2","key":"10.1016\/j.arr.2023.101961_bib87","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/med.21631","article-title":"Hepcidin and its therapeutic potential in neurodegenerative disorders","volume":"40","author":"Qian","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2023.101961_bib88","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1471-4914(00)01910-9","article-title":"Brain iron transport and neurodegeneration","volume":"7","author":"Qian","year":"2001","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.arr.2023.101961_bib89","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-0173(98)00012-5","article-title":"Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders","volume":"27","author":"Qian","year":"1998","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.arr.2023.101961_bib90","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1124\/pr.54.4.561","article-title":"Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway","volume":"54","author":"Qian","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.arr.2023.101961_bib91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/2051-5960-1-55","article-title":"The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease","volume":"1","author":"Raha","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2023.101961_bib92","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3390\/ijms23031060","article-title":"Interplay of ferritin accumulation and ferroportin loss in ageing brain: implication for protein aggregation in down syndrome dementia. Alzheimer's, and Parkinson's diseases","volume":"23","author":"Raha","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101961_bib93","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: implications for neurodegenerative diseases","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2023.101961_bib94","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12011-018-1442-7","article-title":"Iron deficiency reduces synapse formation in the drosophila clock circuit","volume":"189","author":"Rudisill","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.arr.2023.101961_bib95","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.freeradbiomed.2009.11.004","article-title":"Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease","volume":"48","author":"Song","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2023.101961_bib96","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nm.2668","article-title":"Ironing out tau's role in parkinsonism","volume":"18","author":"Stankowski","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2023.101961_bib97","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrneurol.2014.118","article-title":"Iron in multiple sclerosis: roles in neurodegeneration and repair","volume":"10","author":"Stephenson","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2023.101961_bib98","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1096\/fj.15-276758","article-title":"Mice with hepcidin-resistant ferroportin accumulate iron in the retina","volume":"30","author":"Theurl","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2023.101961_bib99","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.2741\/ujiie","article-title":"p97 as a biomarker for Alzheimer disease","volume":"7","author":"Ujiie","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.arr.2023.101961_bib100","doi-asserted-by":"crossref","first-page":"2850341","DOI":"10.1155\/2018\/2850341","article-title":"Unraveling the burden of iron in neurodegeneration: intersections with amyloid beta peptide pathology","volume":"2018","author":"Uranga","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2023.101961_bib101","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jnc.12244","article-title":"Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells","volume":"126","author":"Urrutia","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2023.101961_bib102","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/antiox10010061","article-title":"Inflaming the brain with iron","volume":"10","author":"Urrutia","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2023.101961_bib103","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1111\/j.1460-9568.2007.05515.x","article-title":"Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats","volume":"25","author":"Wang","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib104","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2023.101961_bib105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2003.10.066","article-title":"Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier","volume":"1001","author":"Wu","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2023.101961_bib106","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jtemb.2014.11.009","article-title":"Age-related changes of brain iron load changes in the frontal cortex in APPswe\/PS1\u0394E9 transgenic mouse model of Alzheimer's disease","volume":"30","author":"Xian-hui","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.arr.2023.101961_bib107","first-page":"8684130","article-title":"Hepcidin plays a key role in 6-OHDA induced iron overload and apoptotic cell death in a cell culture model of Parkinson's disease","volume":"2016","author":"Xu","year":"2016","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.arr.2023.101961_bib108","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuint.2015.10.014","article-title":"Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells","volume":"91","author":"Xu","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2023.101961_bib109","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/neup.12611","article-title":"Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains","volume":"40","author":"Yanase","year":"2020","journal-title":"Neuropathology"},{"key":"10.1016\/j.arr.2023.101961_bib110","doi-asserted-by":"crossref","first-page":"L932","DOI":"10.1152\/ajplung.00114.2002","article-title":"Iron increases expression of iron-export protein MTP1 in lung cells","volume":"283","author":"Yang","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.arr.2023.101961_bib111","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/j.1471-4159.2009.06534.x","article-title":"Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation","volume":"112","author":"Yin","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2023.101961_bib112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng0395-267","article-title":"A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans","volume":"9","author":"Yoshida","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2023.101961_bib113","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41419-022-05043-w","article-title":"Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells","volume":"13","author":"You","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2023.101961_bib114","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2009.03.006","article-title":"A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2023.101961_bib115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fnmol.2017.00367","article-title":"Impairment of hepcidin upregulation by lipopolysaccharide in the interleukin-6 knockout mouse brain","volume":"10","author":"Zhang","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2023.101961_bib116","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1002\/jcp.27431","article-title":"Regulating ferroportin-1 and transferrin receptor-1 expression: a novel function of hydrogen sulfide","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.arr.2023.101961_bib117","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2016.10.029","article-title":"(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells","volume":"792","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.arr.2023.101961_bib118","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuroscience.2013.09.037","article-title":"Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models","volume":"257","author":"Zhang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2023.101961_bib119","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/hep.29499","article-title":"Cystathionine \u03b2-synthase is required for body iron homeostasis","volume":"67","author":"Zhou","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.arr.2023.101961_bib120","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bcmd.2002.0587","article-title":"Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1","volume":"29","author":"Zoller","year":"2002","journal-title":"Blood Cells Mol. Dis."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723001204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723001204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:09:34Z","timestamp":1761592174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163723001204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":120,"alternative-id":["S1568163723001204"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2023.101961","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroportin1 in the brain","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2023.101961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101961"}}