{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:11:31Z","timestamp":1789567891529,"version":"build-2803163510"},"reference-count":266,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.arr.2023.101967","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T22:31:59Z","timestamp":1685658719000},"page":"101967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases"],"prefix":"10.1016","volume":"89","author":[{"given":"Caterina","family":"Miceli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Leri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bucciantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.arr.2023.101967_bib1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/CIRCRESAHA.118.312208","article-title":"Autophagy in cardiovascular aging","volume":"123","author":"Abdellatif","year":"2018","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.arr.2023.101967_bib2","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/brain\/awx187","article-title":"Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases","volume":"140","author":"Adriaenssens","year":"2017","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11427-023-2305-0","volume":"66","author":"Aging Biomarker Consortium","year":"2023","journal-title":"Biomark. Aging Sci. China Life Sci."},{"key":"10.1016\/j.arr.2023.101967_bib4","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1016\/j.wneu.2022.08.063","article-title":"Diagnostic potential of autophagy-5 protein, apolipoprotein B-48, and oxidative stress markers in serum of patients with early-stage ischemic stroke","volume":"167","author":"Ajoolabady","year":"2022","journal-title":"World Neurosurg."},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/jnc.12326","article-title":"Optineurin suppression causes neuronal cell death via NF-\u03baB pathway","volume":"126","author":"Akizuki","year":"2013","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2023.101967_bib6","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains","volume":"67","author":"Alvarez-Erviti","year":"2010","journal-title":"Arch. Neurol."},{"issue":"8","key":"10.1016\/j.arr.2023.101967_bib7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2023.101967_bib8","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1101\/gad.287524.116","article-title":"Recent insights into the function of autophagy in cancer","volume":"30","author":"Amaravadi","year":"2016","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib9","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.3390\/cells9112413","article-title":"Amyotrophic lateral sclerosis and autophagy: dysfunction and therapeutic targeting","volume":"9","author":"Amin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2023.101967_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tibs.2016.09.008","article-title":"Emerging mechanisms in initiating and terminating autophagy","volume":"42","author":"Antonioli","year":"2017","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.arr.2023.101967_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ceb.2010.10.009","article-title":"Chaperone-mediated autophagy in protein quality control","volume":"23","author":"Arias","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib12","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.arr.2023.101967_bib13","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.4161\/auto.29165","article-title":"Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma","volume":"10","author":"Barnard","year":"2014","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.arr.2023.101967_bib14","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1080\/15548627.2020.1846302","article-title":"Measurement of autophagic flux in humans: an optimized method for blood samples","volume":"17","author":"Bensalem","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cell.2007.10.048","article-title":"Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila","volume":"131","author":"Berry","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4161\/auto.19227","article-title":"A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress","volume":"8","author":"Betin","year":"2012","journal-title":"Autophagy"},{"issue":"23","key":"10.1016\/j.arr.2023.101967_bib17","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1073\/pnas.1106291108","article-title":"PTEN-inducible kinase 1 (PINK1)\/Park6 is indispensable for normal heart function","volume":"108","author":"Billia","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2023.101967_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4161\/auto.22783","article-title":"Hypoxia, MTOR and autophagy: converging on senescence or quiescence","volume":"9","author":"Blagosklonny","year":"2013","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-013-1125-6","article-title":"Protein aggregation in amyotrophic lateral sclerosis","volume":"125","author":"Blokhuis","year":"2013","journal-title":"Acta Neuropathol. SOD1 Aggreg. ALS: Cause, Correl. Or. Cons\u00e9q. ?"},{"key":"10.1016\/j.arr.2023.101967_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.mad.2004.07.009","article-title":"The role of oxidative damage and stress in aging","volume":"125","author":"Bokov","year":"2004","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14336\/AD.2014.0305","article-title":"Metabolic syndrome, aging and involvement of oxidative stress","volume":"6","author":"Bonomini","year":"2015","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00401-017-1756-0","article-title":"A knock-in\/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8","volume":"135","author":"Bouhy","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/MCB.25.3.1025-1040.2005","article-title":"Inhibition of macroautophagy triggers apoptosis","volume":"25","author":"Boya","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2105\/AJPH.2009.166082","article-title":"Socioeconomic disparities in health in the United States: what the patterns tell us","volume":"100","author":"Braveman","year":"2010","journal-title":"Am. J. Public Health"},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib25","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and mitophagy in cardiovascular disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.20180729","article-title":"Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice","volume":"216","author":"Brenner","year":"2019","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.arr.2023.101967_bib27","doi-asserted-by":"crossref","DOI":"10.3171\/foc.2003.14.2.4","article-title":"Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine","volume":"14","author":"Briceno","year":"2003","journal-title":"Neurosurg. FOCUS"},{"issue":"16","key":"10.1016\/j.arr.2023.101967_bib28","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1056\/NEJMc1710379","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"24","key":"10.1016\/j.arr.2023.101967_bib29","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1021\/jm4011884","article-title":"Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease","volume":"56","author":"B\u00fcrli","year":"2013","journal-title":"J. Med Chem."},{"key":"10.1016\/j.arr.2023.101967_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17047","article-title":"Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling","volume":"5","author":"Calcagn\u00ec","year":"2016","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib31","doi-asserted-by":"crossref","first-page":"G469","DOI":"10.1152\/ajpgi.00049.2020","article-title":"An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase","volume":"319","author":"Carotti","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/dc15-1588","article-title":"Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia","volume":"39","author":"Chatterjee","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arr.2023.101967_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.578418","article-title":"The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity","volume":"10","author":"Chavez-Dominguez","year":"2020","journal-title":"Front Oncol."},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib34","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1476-5381.2008.00102.x","article-title":"Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels","volume":"156","author":"Chen","year":"2009","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.arr.2023.101967_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174495","article-title":"Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K\/AKT\/mTOR pathways","volume":"911","author":"Chen","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib36","first-page":"1574","article-title":"The altered autophagy mediated by TFEB in animal and cell models of amyotrophic lateral sclerosis","volume":"7","author":"Chen","year":"2015","journal-title":"Am. J. Transl. Res"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/07853890.2017.1417631","article-title":"The role of mitochondrial dysfunction in cardiovascular disease: a brief review","volume":"50","author":"Chistiakov","year":"2018","journal-title":"Ann. Med"},{"key":"10.1016\/j.arr.2023.101967_bib38","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/jcb.25171","article-title":"The RUNX2 transcription factor negatively regulates SIRT6 expression to alter glucose metabolism in breast cancer Cells","volume":"116","author":"Choe","year":"2015","journal-title":"J. Cell Biochem"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/15548627.2021.1926656","article-title":"Autophagy and ALS: mechanistic insights and therapeutic implications","volume":"18","author":"Chua","year":"2022","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009313","article-title":"Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy","volume":"5","author":"Crews","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2023.101967_bib41","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4158\/EP13217.RA","article-title":"Andropause or male menopause? Rationale for testosterone replacement therapy in older men with low testosterone levels","volume":"19","author":"Cunningham","year":"2013","journal-title":"Endocr. Pract."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib42","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1093\/hmg\/ddq050","article-title":"Transgenic mice expressing mutant forms VCP\/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone","volume":"19","author":"Custer","year":"2010","journal-title":"Hum. Mol. Genet"},{"issue":"19","key":"10.1016\/j.arr.2023.101967_bib43","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-dependent cell death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2023.101967_bib45","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1016\/j.bbamcr.2013.06.014","article-title":"Developmentally programmed cell death in Drosophila","volume":"833","author":"Denton","year":"2013","journal-title":"Biochim Biophys. Acta"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib47","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2023.101967_bib48","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1136\/annrheumdis-2020-eular.5897","article-title":"AB1237 Diagnostic value of proteasomal and autophagic markers in muscular diseases","volume":"79","author":"Drott","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.arr.2023.101967_bib49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2010.12.016","article-title":"The cell-non-autonomous nature of electron transport chain-mediated longevity","volume":"144","author":"Durieux","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib50","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4161\/auto.5.5.8157","article-title":"Autophagy genes mediate the effect of calcineurin on life span in C. elegans","volume":"5","author":"Dwivedi","year":"2009","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.arr.2023.101967_bib51","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.4049\/jimmunol.1901484","article-title":"T Cell-expressed microRNA-155 reduces lifespan in a mouse model of age-related chronic inflammation","volume":"204","author":"Ekiz","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2023.101967_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144454","article-title":"Disturbed expression of autophagy genes in blood of Parkinson's disease patients","volume":"738","author":"El Haddad","year":"2020","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib53","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1186\/s12885-022-09981-8","article-title":"Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients","volume":"22","author":"El Mashed","year":"2022","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib54","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1089\/rej.2014.1607","article-title":"Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians","volume":"17","author":"Emanuele","year":"2014","journal-title":"Rejuvenation Res"},{"issue":"7708","key":"10.1016\/j.arr.2023.101967_bib55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-018-0162-7","article-title":"Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice","volume":"558","author":"Fern\u00e1ndez","year":"2018","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2023.101967_bib57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047357","article-title":"Chloroquine or chloroquine-PI3K\/Akt pathway inhibitor combinations strongly promote \u03b3-irradiation-induced cell death in primary stem-like glioma cells","volume":"7","author":"Firat","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib59","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/acel.12109","article-title":"Late-life rapamycin treatment reverses age-related heart dysfunction","volume":"12","author":"Flynn","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2023.101967_bib60","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1073\/pnas.0708022105","article-title":"Lithium delays progression of amyotrophic lateral sclerosis","volume":"105","author":"Fornai","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"44","key":"10.1016\/j.arr.2023.101967_bib61","doi-asserted-by":"crossref","first-page":"16172","DOI":"10.1074\/jbc.RA119.009110","article-title":"Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9\/KLHL13\/CUL3-mediated IRS1 degradation","volume":"294","author":"Frendo-Cumbo","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.arr.2023.101967_bib62","doi-asserted-by":"crossref","first-page":"856","DOI":"10.15252\/embj.201490784","article-title":"Autophagy in malignant transformation and cancer progression","volume":"34","author":"Galluzzi","year":"2015","journal-title":"EMBO J."},{"issue":"7584","key":"10.1016\/j.arr.2023.101967_bib63","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib64","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4161\/auto.28264","article-title":"Involvement of autophagy in hypoxic-excitotoxic neuronal death","volume":"10","author":"Ginet","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib65","article-title":"Implication of autophagy in Parkinson's disease","volume":"2013","author":"Gonzalez-Polo","year":"2013","journal-title":"Park. Dis."},{"key":"10.1016\/j.arr.2023.101967_bib66","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib67","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijms20061509","article-title":"Telomerase impinges on the cellular response to oxidative stress through mitochondrial ROS-mediated regulation of autophagy","volume":"20","author":"Green","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101967_bib68","article-title":"- Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans","volume":"383\u20137","author":"Greer","year":"2010","journal-title":"Nature 15;466(7304)"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00726-007-0606-0","article-title":"Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases","volume":"35","author":"Grillo","year":"2008","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib70","first-page":"773","article-title":"Inhibition of autophagy in hepatocarcinoma cells promotes chemotherapeutic agent-induced apoptosis during nutrient deprivation","volume":"39","author":"Guo","year":"2018","journal-title":"Oncol. Rep."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib71","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.celrep.2017.05.024","article-title":"Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS","volume":"19","author":"Hall","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2023.101967_bib72","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1074\/jbc.M113.536854","article-title":"A Complex between Atg7 and Caspase-9","volume":"289","author":"Han","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib73","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41580-018-0033-y","article-title":"Autophagy as a promoter of longevity: insights from model organisms","volume":"19","author":"Hansen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib74","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1080\/15548627.2019.1586255","article-title":"Targetome analysis of chaperone-mediated autophagy in cancer cells","volume":"15","author":"Hao","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib75","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib76","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/152308603770310202","article-title":"The free radical theory of aging","volume":"5","author":"Harman","year":"2003","journal-title":"Antioxid. Redox Signal"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib77","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/auto.3636","article-title":"Autophagy regulates ageing in C. elegans","volume":"3","author":"Hars","year":"2007","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.arr.2023.101967_bib78","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4161\/auto.21327","article-title":"Exercise induces autophagy in peripheral tissues and in the brain","volume":"8","author":"He","year":"2012","journal-title":"Autophagy"},{"issue":"7382","key":"10.1016\/j.arr.2023.101967_bib79","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature10758","article-title":"Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis","volume":"481","author":"He","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib80","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/aps.2012.188","article-title":"Autophagy in ageing and ageing-associated diseases","volume":"34","author":"He","year":"2013","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.arr.2023.101967_bib81","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2020.01.018","article-title":"The journey of the synaptic autophagosome: a cell biological perspective","volume":"105","author":"Hill","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2023.101967_bib82","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature21388","article-title":"Autophagy maintains the metabolism and function of young and old stem cells","volume":"543","author":"Ho","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib83","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/ncomms3308","article-title":"Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart","volume":"4","author":"Hoshino","year":"2013","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.arr.2023.101967_bib84","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.jmb.2020.01.037","article-title":"Autophagy in Parkinson's Disease","volume":"432","author":"Hou","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2023.101967_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.743560","article-title":"A novel autophagy-related marker for improved differential diagnosis of rheumatoid arthritis and osteoarthritis","volume":"12","author":"Huang","year":"2021","journal-title":"Front Genet"},{"issue":"12","key":"10.1016\/j.arr.2023.101967_bib86","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1210\/en.2012-1625","article-title":"Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression","volume":"153","author":"Jansen","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.arr.2023.101967_bib87","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fpubh.2017.00335","article-title":"Age-related diseases and clinical and public health implications for the 85\u2009years old and over population","volume":"5","author":"Jaul","year":"2017","journal-title":"Front Public Health"},{"key":"10.1016\/j.arr.2023.101967_bib88","doi-asserted-by":"crossref","first-page":"26","DOI":"10.21037\/aoj.2020.02.07","article-title":"Autophagy markers and RNA-dependent protein kinase (PKR) activity in osteosarcoma diagnosis and treatment","volume":"5","author":"Ji","year":"2020","journal-title":"Ann. Jt."},{"key":"10.1016\/j.arr.2023.101967_bib89","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2174\/15672050113109990155","article-title":"Epidemiology and etiology of Alzheimer\u2019s disease: from genetic to non-genetic factors","volume":"10","author":"Jiang","year":"2013","journal-title":"Curr. Alzheimer Res"},{"key":"10.1016\/j.arr.2023.101967_bib90","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI73942","article-title":"Autophagy in cellular metabolism and cancer","volume":"125","author":"Jiang","year":"2015","journal-title":"J. Clin. Invest"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41419-019-1393-8","article-title":"Obesity-associated inflammation triggers an autophagy-lysosomal response in adipocytes and causes degradation of perilipin 1","volume":"10","author":"Ju","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2023.101967_bib92","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The gh\/igf-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2023.101967_bib93","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.disamonth.2015.09.005","article-title":"Biological theories of aging","volume":"61","author":"Kamel","year":"2015","journal-title":"Dis. -a-Mon."},{"key":"10.1016\/j.arr.2023.101967_bib94","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30543","article-title":"Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak","volume":"6","author":"Karch","year":"2017","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.arr.2023.101967_bib95","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrurol.2014.162","article-title":"Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers","volume":"11","author":"Kauffman","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.arr.2023.101967_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101468","article-title":"Autophagy and the hallmarks of aging","volume":"72","author":"Kaushik","year":"2021","journal-title":"Ageing Res Rev."},{"issue":"Pt 4","key":"10.1016\/j.arr.2023.101967_bib97","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/jcs.073874","article-title":"Chaperone-mediated autophagy at a glance","volume":"124","author":"Kaushik","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2023.101967_bib98","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib99","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/s12276-022-00873-2","article-title":"NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib100","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/STROKEAHA.117.017287","article-title":"Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke","volume":"49","author":"Kim","year":"2018","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib101","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrendo.2014.35","article-title":"Autophagy--a key player in cellular and body metabolism","volume":"10","author":"Kim","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib102","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.3014","article-title":"Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine","volume":"19","author":"Kim","year":"2013","journal-title":"Nat. Med"},{"issue":"10","key":"10.1016\/j.arr.2023.101967_bib103","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1080\/15548627.2017.1356977","article-title":"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition","volume":"13","author":"Kim","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib104","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.18632\/aging.101068","article-title":"The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis","volume":"8","author":"Kitada","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"19","key":"10.1016\/j.arr.2023.101967_bib105","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"issue":"19","key":"10.1016\/j.arr.2023.101967_bib106","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"issue":"50","key":"10.1016\/j.arr.2023.101967_bib107","doi-asserted-by":"crossref","first-page":"18492","DOI":"10.1523\/JNEUROSCI.3219-11.2011","article-title":"Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease","volume":"31","author":"Koga","year":"2011","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib108","doi-asserted-by":"crossref","first-page":"E268","DOI":"10.1210\/jc.2010-1681","article-title":"Altered autophagy in human adipose tissues in obesity","volume":"6","author":"Kovsan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2023.101967_bib109","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2023.101967_bib110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuron.2020.10.005","article-title":"Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum","volume":"109","author":"Kuijpers","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2023.101967_bib111","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.101967_bib112","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/ncomms1611","article-title":"Muscle-derived stem\/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model","volume":"3","author":"Lavasani","year":"2012","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib113","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10522-022-09951-4","article-title":"Geroscience: the need to address some issues","volume":"23","author":"Le Bourg","year":"2022","journal-title":"Biogerontology"},{"issue":"12","key":"10.1016\/j.arr.2023.101967_bib114","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/s41556-018-0235-8","article-title":"Autophagy and the cell biology of age-related disease","volume":"20","author":"Leidal","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib115","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3390\/ijms21041250","article-title":"Healthy Effects of Plant Polyphenols: Molecular Mechanisms","volume":"21","author":"Leri","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101967_bib116","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/446745a","article-title":"Cell biology: autophagy and cancer","volume":"446","author":"Levine","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib117","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib118","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pharmthera.2011.03.009","article-title":"Targeting autophagy during cancer therapy to improve clinical outcomes","volume":"131","author":"Levy","year":"2011","journal-title":"Pharmcol Ther."},{"key":"10.1016\/j.arr.2023.101967_bib119","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s12967-015-0726-3","article-title":"Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients","volume":"13","author":"Li","year":"2015","journal-title":"J. Transl. Med"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/abbs\/gmw025","article-title":"The role of autophagy in cardiac hypertrophy","volume":"48","author":"Li","year":"2016","journal-title":"Acta Biochim Biophys. Sin. (Shanghai)"},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib121","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/hep.29229","article-title":"Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.arr.2023.101967_bib122","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00018-011-0865-5","article-title":"Microautophagy: lesser-known self-eating","volume":"69","author":"Li","year":"2012","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib123","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41420-022-00991-w","article-title":"Modulation of energy metabolism to overcome drug resistance in chronic myeloid leukemia cells through induction of autophagy","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib124","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1016\/j.apsb.2021.07.012","article-title":"Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10522-021-09910-5","article-title":"Aging and age-related diseases: from mechanisms to therapeutic strategies","volume":"22","author":"Li","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2023.101967_bib126","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12264-013-1418-8","article-title":"Dysfunctional autophagy in Alzheimer\u2019s disease: pathogenic roles and therapeutic implications","volume":"30","author":"Liang","year":"2014","journal-title":"Neurosci. Bull."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib127","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12964-020-00576-z","article-title":"Neddylation inhibition activates the protective autophagy through NF-\u03baB-catalase-ATF3 Axis in human esophageal cancer cells","volume":"18","author":"Liang","year":"2020","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib128","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41467-018-03939-w","article-title":"A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes","volume":"9","author":"Lim","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2023.101967_bib129","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1038\/ncomms5934","article-title":"Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes","volume":"5","author":"Lim","year":"2014","journal-title":"Nat. Commun."},{"issue":"45","key":"10.1016\/j.arr.2023.101967_bib130","doi-asserted-by":"crossref","first-page":"31484","DOI":"10.1074\/jbc.M109.033936","article-title":"Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2023.101967_bib131","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/cdd.2014.143","article-title":"Autosis and autophagic cell death: the dark side of autophagy","volume":"22","author":"Liu","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2023.101967_bib132","first-page":"1","article-title":"Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2023.101967_bib133","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1210\/jc.2012-4070","article-title":"Where are we 10 years after the women\u2019s health initiative?","volume":"98","author":"Lobo","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2023.101967_bib134","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103207","article-title":"Transcription factor EB regulates cardiovascular homeostasis","volume":"63","author":"Lu","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2023.101967_bib136","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/FJC.0000000000000342","article-title":"Autophagy: an exposing therapeutic target in atherosclerosis","volume":"67","author":"Luo","year":"2016","journal-title":"J. Cardiovasc. Pharm."},{"issue":"13","key":"10.1016\/j.arr.2023.101967_bib137","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1158\/0008-5472.CAN-12-0388","article-title":"The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth","volume":"72","author":"Luo","year":"2012","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib138","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1021\/acschemneuro.8b00516","article-title":"SQSTM1\/p62: A Potential Target for Neurodegenerative Disease","volume":"10","author":"Ma","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2023.101967_bib139","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib140","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1523\/JNEUROSCI.3944-09.2010","article-title":"Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease","volume":"30","author":"Malagelada","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib141","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cmet.2016.11.003","article-title":"Transcription Factor EB Controls Metabolic Flexibility during Exercise","volume":"25","author":"Mansueto","year":"2017","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.arr.2023.101967_bib142","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/RES.0b013e3182194c29","article-title":"AMPK activates autophagy by phosphorylating ULK1","volume":"108","author":"Mao","year":"2011","journal-title":"Circ. Res"},{"key":"10.1016\/j.arr.2023.101967_bib143","doi-asserted-by":"crossref","first-page":"8023821","DOI":"10.1155\/2018\/8023821","article-title":"Autophagy modulation in cancer: current knowledge on action and therapy","volume":"2018","author":"Marinkovic","year":"2018","journal-title":"Oxid. Med Cell Longev."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib144","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"Mari\u00f1o","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-Consumption: The Interplay of Autophagy and Apoptosis","volume":"15","author":"Mari\u00f1o","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib146","first-page":"123","article-title":"The role of autophagy in aging: molecular mechanisms. Autoph Cancer Other Pathol Inflamm Immunity Infect","author":"Markaki","year":"2017","journal-title":"Aging"},{"key":"10.1016\/j.arr.2023.101967_bib147","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cell.2019.02.009","article-title":"ATG8-binding UIM proteins define a new class of autophagy adaptors and receptors","volume":"177","author":"Marshall","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib148","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-2404-2_3","article-title":"Autophagy and aging","volume":"847","author":"Martinez-Lopez","year":"2015","journal-title":"Adv. Exp. Med Biol."},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib149","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease","volume":"13","author":"Martinez-Vicente","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib150","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tins.2016.02.002","article-title":"The autophagy-lysosomal pathway in neurodegeneration: a TFEB perspective","volume":"39","author":"Martini-Stoica","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2023.101967_bib151","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.mad.2011.08.001","article-title":"Assessment of a large panel of candidate biomarkers of ageing in the newcastle 85+ study","volume":"132","author":"Martin-Ruiz","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2023.101967_bib152","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acel.12427","article-title":"Long live FOXO: unraveling the role of FOXO proteins in aging and longevity","volume":"15","author":"Martins","year":"2016","journal-title":"Aging Cell"},{"issue":"5\u20136","key":"10.1016\/j.arr.2023.101967_bib153","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.mam.2006.08.002","article-title":"Signalling and autophagy regulation in health, aging and disease","volume":"27","author":"Meijer","year":"2006","journal-title":"Mol. Asp. Med."},{"issue":"5638","key":"10.1016\/j.arr.2023.101967_bib154","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans","volume":"301","author":"Mel\u00e9ndez","year":"2003","journal-title":"Science"},{"issue":"37","key":"10.1016\/j.arr.2023.101967_bib155","doi-asserted-by":"crossref","first-page":"32324","DOI":"10.1074\/jbc.M111.254417","article-title":"Defective hypothalamic autophagy directs the central pathogenesis of obesity via IKK-beta\/NF-kappaB pathway","volume":"286","author":"Meng","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib156","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41419-020-2275-9","article-title":"Autophagy in metabolic syndrome: breaking the wheel by targeting the renin-angiotensin system","volume":"11","author":"Menikdiwela","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib157","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib158","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/EBC20170022","article-title":"Autophagy in health and disease: focus on the cardiovascular system","volume":"61","author":"Mialet-Perez","year":"2017","journal-title":"Essays Biochem"},{"key":"10.1016\/j.arr.2023.101967_bib159","doi-asserted-by":"crossref","first-page":"8067592","DOI":"10.1155\/2018\/8067592","article-title":"Oleuropein aglycone protects against MAO-A-induced autophagy impairment and cardiomyocyte death through activation of TFEB","volume":"2018","author":"Miceli","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.arr.2023.101967_bib160","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib161","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in Mammalian Autophagy Research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib162","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib163","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/jcm9030892","article-title":"Mitophagy in Cardiovascular Diseases","volume":"9","author":"Morciano","year":"2020","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.arr.2023.101967_bib164","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.18632\/aging.102181","article-title":"Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy","volume":"11","author":"Moreno-Blas","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"19","key":"10.1016\/j.arr.2023.101967_bib165","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.4161\/cc.7.19.6751","article-title":"Mutant p53 protein localized in the cytoplasm inhibits autophagy","volume":"7","author":"Morselli","year":"2008","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2009.8","article-title":"Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy","volume":"1","author":"Morselli","year":"2010","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib167","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/cn500056q","article-title":"Lithium and autophagy","volume":"5","author":"Motoi","year":"2014","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib168","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI64209","article-title":"p62 links \u03b2-adrenergic input to mitochondrial function and thermogenesis","volume":"123","author":"M\u00fcller","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.101967_bib169","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00401-004-0821-7","article-title":"Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum","volume":"107","author":"Nakano","year":"2004","journal-title":"Acta Neuropathol."},{"issue":"7826","key":"10.1016\/j.arr.2023.101967_bib170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-020-2444-0","article-title":"A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dub\u00e9 syndrome","volume":"585","author":"Napolitano","year":"2020","journal-title":"Nature"},{"issue":"7741","key":"10.1016\/j.arr.2023.101967_bib171","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41586-019-0885-0","article-title":"Autophagic cell death restricts chromosomal instability during replicative crisis","volume":"565","author":"Nassour","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib172","first-page":"1004","article-title":"Intersection of apoptosis and autophagy cell death pathways","volume":"2","author":"Noguchi","year":"2015","journal-title":"Austin J. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2023.101967_bib173","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCRESAHA.116.303805","article-title":"The role of autophagy in vascular biology","volume":"116","author":"Nussenzweig","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2023.101967_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101374","article-title":"miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases","volume":"70","author":"Olivieri","year":"2021","journal-title":"Ageing Res Rev."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib175","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2016.02.107","article-title":"Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2","volume":"472","author":"Osaka","year":"2016","journal-title":"Biochem Biophys. Res Commun."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib176","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents","volume":"21","author":"Pajak","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.101967_bib177","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2019.04.003","article-title":"Autophagy dysfunction in peripheral blood mononuclear cells of Parkinson's disease patients","volume":"704","author":"Papagiannakis","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2023.101967_bib178","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1038\/ncomms7823","article-title":"Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage","volume":"6","author":"Park","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2023.101967_bib179","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-cancerbio-030518-055835","article-title":"MiT\/TFE family of transcription factors, lysosomes, and cancer","volume":"3","author":"Perera","year":"2019","journal-title":"Annu Rev. Cancer Biol."},{"issue":"7565","key":"10.1016\/j.arr.2023.101967_bib180","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature14587","article-title":"Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism","volume":"524","author":"Perera","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib181","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/cancers11101599","article-title":"Targeting autophagy for cancer treatment and tumor chemosensitization","volume":"11","author":"P\u00e9rez-Hern\u00e1ndez","year":"2019","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib182","first-page":"2190","article-title":"The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice","volume":"118","author":"Pickford","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.101967_bib183","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2010.04.022","article-title":"Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease","volume":"477","author":"Prigione","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib184","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798804","article-title":"The complex relationship between TFEB transcription factor phosphorylation and subcellular localization","volume":"37","author":"Puertollano","year":"2018","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib185","first-page":"515","article-title":"A therapeutic target for inhibition of neurodegeneration: autophagy","volume":"66","author":"Pupyshev","year":"2016","journal-title":"Zh. . Vyss. Nerv. Deiat Im. I P Pavlov."},{"key":"10.1016\/j.arr.2023.101967_bib186","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/ncomms3300","article-title":"Overexpression of Atg5 in mice activates autophagy and extends lifespan","volume":"4","author":"Pyo","year":"2013","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib187","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2010.07.018","article-title":"ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death","volume":"142","author":"Radoshevich","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib188","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/ncomms4056","article-title":"A dual role for autophagy in a murine model of lung cancer","volume":"5","author":"Rao","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib189","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1038\/s41598-019-46749-w","article-title":"Discrete Changes in Glucose Metabolism Define Aging","volume":"9","author":"Ravera","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib190","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.celrep.2016.02.006","article-title":"Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency","volume":"14","author":"Reddy","year":"2016","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.arr.2023.101967_bib191","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.tips.2018.10.005","article-title":"Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases","volume":"39","author":"Ren","year":"2018","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.arr.2023.101967_bib192","series-title":"Aging, From Fundamental Biology to Societal Impact","first-page":"257","article-title":"Chapter 9-Intercellular communication and aging","author":"Ribeiro-Rodrigues","year":"2023"},{"key":"10.1016\/j.arr.2023.101967_bib193","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.biocel.2016.07.020","article-title":"Defending the mitochondria: the pathways of mitophagy and mitochondrial-derived vesicles","volume":"79","author":"Roberts","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib194","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbd.2010.11.003","article-title":"Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer\u2019s disease brain","volume":"43","author":"Rohn","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib195","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1093\/hmg\/ddq093","article-title":"Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease","volume":"19","author":"Rose","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.arr.2023.101967_bib196","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3390\/brainsci12101414","article-title":"Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?","volume":"12","author":"Rubino","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.arr.2023.101967_bib197","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2011.10.014","article-title":"The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis","volume":"44","author":"Rubinstein","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2023.101967_bib198","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.101967_bib199","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2012.12.008","article-title":"Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease","volume":"52","author":"Ru\u00e9","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2023.101967_bib200","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fnmol.2017.00176","article-title":"The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases","volume":"10","author":"Rusmini","year":"2017","journal-title":"Front Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib201","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/ars.2015.6522","article-title":"Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure","volume":"25","author":"Santin","year":"2016","journal-title":"Antioxid. Redox Signal"},{"issue":"23","key":"10.1016\/j.arr.2023.101967_bib202","doi-asserted-by":"crossref","first-page":"14632","DOI":"10.3390\/ijms232314632","article-title":"Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases","volume":"23","author":"Sanz-Ros","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"5939","key":"10.1016\/j.arr.2023.101967_bib203","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib204","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3233\/JAD-150980","article-title":"Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease","volume":"51","author":"Schilling","year":"2016","journal-title":"J. Alzheimers Dis."},{"issue":"15","key":"10.1016\/j.arr.2023.101967_bib205","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/eurheartj\/ehr077","article-title":"Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study","volume":"32","author":"Schramm","year":"2011","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.arr.2023.101967_bib206","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.20407","article-title":"Mutant valosin-containing protein causes a novel type of frontotemporal dementia","volume":"57","author":"Schr\u00f6der","year":"2005","journal-title":"Ann. Neurol."},{"issue":"6036","key":"10.1016\/j.arr.2023.101967_bib207","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib208","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib209","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1755-5949.2012.00295.x","article-title":"Excessive autophagy contributes to neuron death in cerebral ischemia","volume":"18","author":"Shi","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2023.101967_bib210","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ncb1192","article-title":"A role of Bcl-2 family of proteins in non-apoptotic programmed cell death dependent on autophagy genes","volume":"6","author":"Shimizu","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.arr.2023.101967_bib211","first-page":"3329","article-title":"Autophagy regulates adipose mass and differentiation in mice","volume":"119","author":"Singh","year":"2009","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.101967_bib212","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib213","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1750-1326-8-31","article-title":"Rapamycin increases survival in ALS mice lacking mature lymphocytes","volume":"8","author":"Staats","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2023.101967_bib214","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3389\/fnins.2018.01022","article-title":"Crosstalk Between Autophagy and Cerebral Ischemia","volume":"12","author":"Sun","year":"2019","journal-title":"Front Neurosci."},{"key":"10.1016\/j.arr.2023.101967_bib215","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/15548627.2016.1247143","article-title":"Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence","volume":"13","author":"Tai","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib216","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mad.2016.12.011","article-title":"Autophagy induction reduces telomerase activity in HeLa cells","volume":"163","author":"Taji","year":"2017","journal-title":"Mech. Ageing Dev."},{"issue":"8","key":"10.1016\/j.arr.2023.101967_bib217","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/s41418-022-01028-6","article-title":"Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease","volume":"29","author":"Tan","year":"2022","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib218","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm985","article-title":"Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease","volume":"10","author":"Tanaka","year":"2004","journal-title":"Nat. Med"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib219","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hep.28820","article-title":"Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice","volume":"64","author":"Tanaka","year":"2016","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib220","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4161\/auto.6.5.11947","article-title":"Inhibition of autophagy in the heart induces age-related cardiomyopathy","volume":"6","author":"Taneike","year":"2010","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib221","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/21691401.2019.1699822","article-title":"Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease","volume":"48","author":"Tang","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.arr.2023.101967_bib222","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fmolb.2016.00079","article-title":"Mutations in the human AAA (+) chaperone p97 and related diseases","volume":"3","author":"Tang","year":"2016","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.arr.2023.101967_bib223","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ebiom.2016.10.034","article-title":"Therapeutic targeting of autophagy","volume":"14","author":"Towers","year":"2016","journal-title":"EBioMedicine"},{"issue":"6990","key":"10.1016\/j.arr.2023.101967_bib224","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.arr.2023.101967_bib225","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/cdd.2017.43","article-title":"Caspase involvement in autophagy","volume":"24","author":"Tsapras","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2023.101967_bib226","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1\u03b1 rescues Huntington\u2019s disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.arr.2023.101967_bib227","doi-asserted-by":"crossref","first-page":"b4731","DOI":"10.1136\/bmj.b4731","article-title":"Risk of cardiovascular disease and all-cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database","volume":"339","author":"Tzoulaki","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.arr.2023.101967_bib228","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2014.08.006","article-title":"AMPK modulates tissue and organismal aging in a non-cell-autonomous manner","volume":"8","author":"Ulgherait","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2023.101967_bib229","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.tcb.2009.07.007","article-title":"The regulation of aging: does autophagy underlie longevity?","volume":"19","author":"Vellai","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib230","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng.95","article-title":"DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice","volume":"40","author":"Vermulst","year":"2008","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib231","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3390\/antiox11040698","article-title":"Aging-Related Decline of Autophagy in Patients with Atrial Fibrillation-A Post Hoc Analysis of the ATHERO-AF Study","volume":"11","author":"Versaci","year":"2022","journal-title":"Antioxid. (Basel)"},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib232","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/nu8060338","article-title":"Biomarkers of aging: from function to molecular biology","volume":"8","author":"Wagner","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2023.101967_bib233","doi-asserted-by":"crossref","first-page":"15","DOI":"10.25215\/0403.142","article-title":"Theories of aging","volume":"4","author":"Wahab Pathath","year":"2017","journal-title":"Artic. Int J. Indian Psychol."},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib234","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41467-017-02332-3","article-title":"Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2023.101967_bib235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0042-16.2016","article-title":"TFEB overexpression in the P301S model of tauopathy mitigates increased PHF1 levels and lipofuscin puncta and rescues memory deficits","volume":"3","author":"Wang","year":"2016","journal-title":"Eneuro"},{"issue":"2","key":"10.1016\/j.arr.2023.101967_bib236","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nchembio.1406","article-title":"Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway","volume":"10","author":"Wang","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2023.101967_bib237","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.2147\/DMSO.S366907","article-title":"Clinical significance of glomerular autophagy in evaluation of diabetic kidney disease progression","volume":"15","author":"Wang","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"issue":"9","key":"10.1016\/j.arr.2023.101967_bib238","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41419-019-1931-4","article-title":"Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet","volume":"10","author":"Wang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2023.101967_bib239","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.arr.2023.101967_bib240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1172\/JCI73941","article-title":"The role for autophagy in cancer (White, 2015)","volume":"125","author":"White","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2023.101967_bib241","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tins.2008.07.004","article-title":"Polyglutamine neurodegeneration: protein misfolding revisited","volume":"31","author":"Williams","year":"2008","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.arr.2023.101967_bib242","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1158\/0008-5472.CAN-08-2872","article-title":"Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy","volume":"69","author":"Wu","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.arr.2023.101967_bib243","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.1038\/srep12291","article-title":"Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2023.101967_bib244","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/cells9010070","article-title":"Autophagy and macrophage functions: inflammatory response and phagocytosis","volume":"9","author":"Wu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2023.101967_bib245","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41556-020-00579-5","article-title":"SIRT1 is downregulated by autophagy in senescence and ageing","volume":"22","author":"Xu","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2023.101967_bib246","doi-asserted-by":"crossref","first-page":"8920926","DOI":"10.1155\/2022\/8920926","article-title":"Diagnostic value and prognostic evaluation of autophagy-related protein expression level in sepsis complicated with acute respiratory distress syndrome","volume":"2022","author":"Xu","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.arr.2023.101967_bib247","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/cdd.2015.28","article-title":"Distinct requirements of autophagy-related genes in programmed cell death","volume":"22","author":"Xu","year":"2015","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib248","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00018-020-03667-9","article-title":"Selective autophagy as a therapeutic target for neurological diseases","volume":"78","author":"Xu","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2023.101967_bib249","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3892\/ijmm.2016.2615","article-title":"Epigallocatechin gallate exerts protective effects against myocardial ischemia\/reperfusion injury through the PI3K\/Akt pathway-mediated inhibition of apoptosis and the restoration of the autophagic flux","volume":"38","author":"Xuan","year":"2016","journal-title":"Int. J. Mol. Med"},{"key":"10.1016\/j.arr.2023.101967_bib250","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","article-title":"Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2023.101967_bib251","first-page":"248","article-title":"How to live long and prosper: autophagy, mitochondria, and aging","volume":"23","author":"Yen","year":"2008","journal-title":"Physiol. (Bethesda)"},{"key":"10.1016\/j.arr.2023.101967_bib252","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib253","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1096645","article-title":"Regulation of an ATG7-Beclin 1 program of autophagic cell death by caspase-8","volume":"304","author":"Yu","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.101967_bib254","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.4161\/auto.26058","article-title":"Regulation of PIK3C3\/VPS34 complexes by MTOR in nutrient stress-induced autophagy","volume":"9","author":"Yuan","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2023.101967_bib255","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm.1851","article-title":"Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function","volume":"14","author":"Zhang","year":"2008","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.arr.2023.101967_bib256","doi-asserted-by":"crossref","first-page":"E530","DOI":"10.1152\/ajpendo.00640.2012","article-title":"Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPAR\u03b32 degradation","volume":"305","author":"Zhang","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2023.101967_bib257","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12035-014-8787-5","article-title":"Defective Autophagy in Parkinson\u2019s Disease: Lessons from Genetics","volume":"51","author":"Zhang","year":"2015","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.arr.2023.101967_bib258","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","article-title":"Epigenetic modifications in cardiovascular aging and diseases","volume":"123","author":"Zhang","year":"2018","journal-title":"Circ. Res"},{"key":"10.1016\/j.arr.2023.101967_bib259","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41420-020-0265-4","article-title":"Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases","volume":"6","author":"Zhang","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.arr.2023.101967_bib260","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.753039","article-title":"Ketogenic Diets and Cardio-Metabolic Diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.arr.2023.101967_bib261","doi-asserted-by":"crossref","first-page":"588","DOI":"10.4161\/auto.27710","article-title":"MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis","volume":"10","author":"Zhang","year":"2014","journal-title":"Autophagy"},{"issue":"47","key":"10.1016\/j.arr.2023.101967_bib262","doi-asserted-by":"crossref","first-page":"19860","DOI":"10.1073\/pnas.0906048106","article-title":"Adipose-specific deletion of autophagy-related gene 7 (Atg7) in mice reveals a role in adipogenesis","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2023.101967_bib263","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41420-022-01074-6","article-title":"The combination of hydroxychloroquine and 2-deoxyglucose enhances apoptosis in breast cancer cells by blocking protective autophagy and sustaining endoplasmic reticulum stress","volume":"8","author":"Zhou","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.arr.2023.101967_bib264","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/cbin.11015","article-title":"Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy","volume":"42","author":"Zhou","year":"2018","journal-title":"Cell Biol. Int"},{"issue":"5","key":"10.1016\/j.arr.2023.101967_bib265","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.3892\/mmr.2017.6403","article-title":"Role of autophagy in advanced atherosclerosis (Review)","volume":"15","author":"Zhu","year":"2017","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.arr.2023.101967_bib266","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4054\/DemRes.2016.34.10","article-title":"Childhood socioeconomic status, adult socioeconomic status, and old-age health trajectories: connecting early, middle, and late life","volume":"34","author":"Zimmer","year":"2016","journal-title":"Demogr. Res."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723001265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723001265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:09:59Z","timestamp":1761592199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163723001265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":266,"alternative-id":["S1568163723001265"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2023.101967","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2023.101967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101967"}}