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USA, 83, 4913\u20134917. https:\/\/doi.org\/10.1073\/PNAS.83.13.4913.","DOI":"10.1073\/pnas.83.13.4913"},{"key":"10.1016\/j.arr.2023.102002_bib73","doi-asserted-by":"crossref","first-page":"13812","DOI":"10.1074\/jbc.RA120.012587","article-title":"Truncation of Tau selectively facilitates its pathological activities","volume":"295","author":"Gu","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2023.102002_bib74","doi-asserted-by":"crossref","unstructured":"Gu\u00e9vremont, D., Tsui, H., Knight, R., Fowler, C.J., Masters, C.L., Martins, R.N., Abraham, W.C., Tate, W.P., Cutfield, N.J., Williams, J.M., 2022. Plasma microRNA vary in association with the progression of Alzheimer\u2019s disease. Alzheimer\u2019s Dement., Amsterdam, Netherlands, 14. https:\/\/doi.org\/10.1002\/DAD2.12251.","DOI":"10.1002\/dad2.12251"},{"key":"10.1016\/j.arr.2023.102002_bib75","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2011.03.022","article-title":"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain","volume":"145","author":"Guo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.102002_bib76","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1096\/fasebj.11.14.9409544","article-title":"Pathways of ubiquitin conjugation","volume":"11","author":"Haas","year":"1997","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2023.102002_bib77","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3233\/JAD-160907","article-title":"Recent progress in Alzheimer\u2019s disease research, part 3: Diagnosis and treatment","volume":"57","author":"Hane","year":"2017","journal-title":"J. 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Commun."},{"key":"10.1016\/j.arr.2023.102002_bib92","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.nbd.2007.11.001","article-title":"A microRNA-based gene dysregulation pathway in Huntington\u2019s disease","volume":"29","author":"Johnson","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2023.102002_bib93","doi-asserted-by":"crossref","first-page":"42867","DOI":"10.1074\/jbc.M112.407072","article-title":"BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus","volume":"287","author":"Kang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2023.102002_bib94","first-page":"8","article-title":"MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system","author":"Kapsimali","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.arr.2023.102002_bib95","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1002\/1873-3468.12472","article-title":"Carbamylation of the amino-terminal residue (Gly1) of mouse serum amyloid A promotes amyloid formation in a cell culture model","volume":"590","author":"Kluve-Beckerman","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2023.102002_bib96","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.1975411","article-title":"miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis","volume":"25","author":"Kole","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.arr.2023.102002_bib97","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2017.00056","article-title":"Lysine-directed post-translational modifications of tau protein in Alzheimer\u2019s disease and related tauopathies","author":"Kontaxi","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.arr.2023.102002_bib98","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0896-6273(89)90077-9","article-title":"Developmentally regulated expression of specific tau sequences","volume":"2","author":"Kosik","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2023.102002_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.00288","article-title":"The regulation of microRNAs in Alzheimer\u2019s disease","author":"Kou","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2023.102002_bib100","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/j.bbagen.2018.07.030","article-title":"Carbamylation promotes amyloidogenesis and induces structural changes in Tau-core hexapeptide fibrils","volume":"1862","author":"KrishnaKumar","year":"2018","journal-title":"Biochim. Biophys. Acta Gen. 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Ther."},{"key":"10.1016\/j.arr.2023.102002_bib103","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2011.07.001","article-title":"Nitration of tyrosine 10 critically enhances amyloid \u03b2 aggregation and plaque formation","volume":"71","author":"Kummer","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2023.102002_bib104","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1093\/nar\/gks218","article-title":"The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes","volume":"40","author":"Kuzuo\u01e7lu-\u00d6zt\u00fcrk","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.arr.2023.102002_bib105","doi-asserted-by":"crossref","unstructured":"Lam, Y.A., Pickart, C.M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R.J., Layfield, R., 2000. Inhibition of the ubiquitin-proteasome system in Alzheimer\u2019s disease. Proc. Natl. Acad. Sci. USA, 97, 9902\u20139906. https:\/\/doi.org\/10.1073\/PNAS.170173897.","DOI":"10.1073\/pnas.170173897"},{"key":"10.1016\/j.arr.2023.102002_bib106","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.279.5348.242","article-title":"Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer\u2019s and Down patients","volume":"279","author":"Leeuwen","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.102002_bib107","doi-asserted-by":"crossref","first-page":"33435","DOI":"10.1074\/jbc.M110.149419","article-title":"Spectroscopic studies of GSK3\\{beta\\} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E","volume":"285","author":"Leroy","year":"2010","journal-title":"J. Biol. 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Rep."},{"key":"10.1016\/j.arr.2023.102002_bib111","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00221-014-4100-0","article-title":"Epigenetic modulation of Cdk5 contributes to memory deficiency induced by amyloid fibrils","volume":"233","author":"Li","year":"2015","journal-title":"Exp. Brain Res"},{"key":"10.1016\/j.arr.2023.102002_bib112","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1038\/emboj.2011.376","article-title":"Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration","volume":"30","author":"Li","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2023.102002_bib113","doi-asserted-by":"crossref","unstructured":"Li, Y., Wang, H., Wang, S., Quon, D., Liu, Y.W., Cordell, B., 2003. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc. Natl. Acad. Sci. 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USA, 93, 11047\u201311052. https:\/\/doi.org\/10.1073\/PNAS.93.20.11047.","DOI":"10.1073\/pnas.93.20.11047"},{"key":"10.1016\/j.arr.2023.102002_bib115","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1016\/j.febslet.2006.10.033","article-title":"PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners","volume":"580","author":"Liu","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2023.102002_bib116","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neurobiolaging.2010.04.034","article-title":"MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer\u2019s-associated pathogenesis in SAMP8 mice","volume":"33","author":"Liu","year":"2012","journal-title":"Neurobiol. 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Lett."},{"key":"10.1016\/j.arr.2023.102002_bib120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ymthe.2020.09.003","article-title":"Melatonin induction of APP intracellular domain 50 SUMOylation alleviates AD through enhanced transcriptional activation and A\u03b2 degradation","volume":"29","author":"Liu","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.arr.2023.102002_bib121","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41380-018-0266-3","article-title":"Novel upregulation of amyloid-\u03b2 precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5\u2019-untranslated region: implications in Alzheimer\u2019s disease","volume":"24","author":"Long","year":"2019","journal-title":"Mol. 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USA, 111, 16586\u201316591. https:\/\/doi.org\/10.1073\/PNAS.1417548111.","DOI":"10.1073\/pnas.1417548111"},{"key":"10.1016\/j.arr.2023.102002_bib125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-319-53889-1_18","article-title":"Alzheimer\u2019s disease and ncRNAs","volume":"978","author":"Maoz","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.arr.2023.102002_bib126","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejmech.2015.10.018","article-title":"Pivotal role of glycogen synthase kinase-3: a therapeutic target for Alzheimer\u2019s disease","volume":"107","author":"Maqbool","year":"2016","journal-title":"Eur. J. Med. 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