{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:51:29Z","timestamp":1788501089144,"version":"build-2803163510"},"reference-count":217,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-MS-322"],"award-info":[{"award-number":["2022-MS-322"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017683","name":"Dalian Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["2022JJ12SN045"],"award-info":[{"award-number":["2022JJ12SN045"]}],"id":[{"id":"10.13039\/501100017683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.arr.2023.102094","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:48:17Z","timestamp":1697629697000},"page":"102094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?"],"prefix":"10.1016","volume":"92","author":[{"given":"Shengxu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-1193","authenticated-orcid":false,"given":"Zhonghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2023.102094_bib1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1097\/01.brs.0000231761.73859.2c","article-title":"What is intervertebral disc degeneration, and what causes it?","volume":"31","author":"Adams","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.arr.2023.102094_bib2","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-015-0183-1","article-title":"Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGF\u03b2 receptors in a rabbit model of disc degeneration","volume":"6","author":"Ahn","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI118884","article-title":"The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration","volume":"98","author":"Antoniou","year":"1996","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.102094_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.22203\/eCM.v032a11","article-title":"Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration","volume":"32","author":"Bach","year":"2016","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.arr.2023.102094_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-023-01010-7","article-title":"Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells","author":"Bertolino","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.arr.2023.102094_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41584-020-00568-w","article-title":"Cell-based strategies for IVD repair: clinical progress and translational obstacles","volume":"17","author":"Binch","year":"2021","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.arr.2023.102094_bib7","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1194\/jlr.R084640","article-title":"Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA","volume":"59","author":"Boilard","year":"2018","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.arr.2023.102094_bib8","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192708","article-title":"ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc","volume":"39","author":"Cai","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.arr.2023.102094_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103601","article-title":"MicroRNAs in intervertebral disc degeneration, apoptosis, inflammation, and mechanobiology","volume":"21","author":"Cazzanelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/0269215517719952","article-title":"Surgical versus non-operative treatment for lumbar disc herniation: a systematic review and meta-analysis","volume":"32","author":"Chen","year":"2018","journal-title":"Clin. Rehabil."},{"key":"10.1016\/j.arr.2023.102094_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/os.12886","article-title":"Inhibition of the P53\/P21 pathway attenuates the effects of senescent nucleus pulposus cell-derived exosomes on the senescence of nucleus pulposus cells","volume":"13","author":"Chen","year":"2021","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.arr.2023.102094_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113066","article-title":"Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1","volume":"414","author":"Chen","year":"2022","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.arr.2023.102094_bib13","first-page":"163","article-title":"hASCs-derived exosomal miR-155-5p targeting TGF\u03b2R2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration","volume":"39","author":"Chen","year":"2023","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.arr.2023.102094_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jcp.20765","article-title":"Tissue-engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF-beta1 in platelet-rich plasma.","volume":"209","author":"Chen","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.arr.2023.102094_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/jcmm.13316","article-title":"Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration","volume":"22","author":"Cheng","year":"2018","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.arr.2023.102094_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8040433","article-title":"Curcumin and o-vanillin exhibit evidence of senolytic activity in human IVD Cells In Vitro","volume":"8","author":"Cherif","year":"2019","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.arr.2023.102094_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122822","article-title":"Extracellular vesicles as drug targets and delivery vehicles for cancer therapy","volume":"14","author":"Chitti","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.arr.2023.102094_bib18","first-page":"2290","article-title":"Clinical adjacent-segment pathology after anterior cervical discectomy and fusion: results after a minimum of 10-year follow-up. The spine journal: official journal of the North American Spine","volume":"14","author":"Chung","year":"2014","journal-title":"Society"},{"key":"10.1016\/j.arr.2023.102094_bib19","article-title":"A brief history of nearly EV-erything - the rise and rise of extracellular vesicles","volume":"10","author":"Couch","year":"2021","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.arr.2023.102094_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2141.1971.tb03416.x","article-title":"The presence of contractile proteins in platelet microparticles isolated from human and animal platelet-free plasma","volume":"21","author":"Crawford","year":"1971","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.arr.2023.102094_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/20417314211021679","article-title":"microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation","volume":"12","author":"Cui","year":"2021","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.arr.2023.102094_bib22","article-title":"Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction","volume":"18","author":"Dai","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.arr.2023.102094_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713247","article-title":"Strategies for engineering of extracellular vesicles","volume":"24","author":"Danilushkina","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib24","first-page":"154","article-title":"Angiogenesis in the degeneration of the lumbar intervertebral disc","volume":"3","author":"David","year":"2010","journal-title":"J. Med. Life"},{"key":"10.1016\/j.arr.2023.102094_bib25","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1056\/NEJMcp1512658","article-title":"Clinical practice. Herniated lumbar intervertebral disk","volume":"374","author":"Deyo","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.arr.2023.102094_bib26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jama.2020.0734","article-title":"US health care spending by payer and health condition","volume":"323","author":"Dieleman","year":"2020","journal-title":"Jama"},{"key":"10.1016\/j.arr.2023.102094_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100596","article-title":"Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations","volume":"11","author":"DiStefano","year":"2022","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.arr.2023.102094_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/19476035221113959","article-title":"Hydrogel-embedded poly(lactic-co-glycolic acid) microspheres for the delivery of hMSC-derived exosomes to promote bioactive annulus fibrosus repair","volume":"13","author":"DiStefano","year":"2022","journal-title":"Cartilage"},{"key":"10.1016\/j.arr.2023.102094_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.592118","article-title":"Intervertebral disk degeneration: the microenvironment and tissue engineering strategies","volume":"9","author":"Dou","year":"2021","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib30","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1093\/neuros\/nyw078","article-title":"Intervertebral disk degeneration and repair","volume":"80","author":"Dowdell","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.arr.2023.102094_bib31","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.nano.2011.04.003","article-title":"Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis","volume":"7","author":"Dragovic","year":"2011","journal-title":"Nanomedicine"},{"key":"10.1016\/j.arr.2023.102094_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gene.2008.04.019","article-title":"Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis","volume":"420","author":"Ellman","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.arr.2023.102094_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1533-2500.2006.00059.x","article-title":"Drug delivery systems","volume":"6","author":"Erdine","year":"2006","journal-title":"Pain. Pr."},{"key":"10.1016\/j.arr.2023.102094_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106107","article-title":"Risk of intervertebral disc joint puncture during lumbar puncture","volume":"200","author":"Ertas","year":"2021","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.arr.2023.102094_bib35","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1089\/hum.2019.005","article-title":"Lentiviral CRISPR epigenome editing of inflammatory receptors as a gene therapy strategy for disc degeneration","volume":"30","author":"Farhang","year":"2019","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.arr.2023.102094_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.835976","article-title":"Degenerative nucleus pulposus cells derived exosomes promoted cartilage endplate cells apoptosis and aggravated intervertebral disc degeneration","volume":"9","author":"Feng","year":"2022","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.arr.2023.102094_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073576","article-title":"Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine","volume":"22","author":"Fern\u00e1ndez-Francos","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/abio.1994.1350","article-title":"Iodixanol: a nonionic iso-osmotic centrifugation medium for the formation of self-generated gradients","volume":"220","author":"Ford","year":"1994","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.arr.2023.102094_bib39","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: from mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2023.102094_bib40","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1242\/dev.126.6.1305","article-title":"Mechanisms of GDF-5 action during skeletal development","volume":"126","author":"Francis-West","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.arr.2023.102094_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ng1092-93","article-title":"A brief history of gene therapy","volume":"2","author":"Friedmann","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2023.102094_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.650664","article-title":"The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy","volume":"9","author":"Garc\u00eda-Bernal","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2023.102094_bib43","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.arr.2023.102094_bib44","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.2147\/JIR.S382069","article-title":"Pyroptosis and intervertebral disc degeneration: mechanistic insights and therapeutic implications","volume":"15","author":"Ge","year":"2022","journal-title":"J. Inflamm. Res"},{"key":"10.1016\/j.arr.2023.102094_bib45","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.spinee.2022.01.012","article-title":"Extracellular vesicle and soluble fractions of adipose tissue-derived mesenchymal stem cells secretome induce inflammatory cytokines modulation in an in vitro model of discogenic pain","volume":"22","author":"Gonz\u00e1lez-Cubero","year":"2022","journal-title":"Spine J."},{"key":"10.1016\/j.arr.2023.102094_bib46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrm2755","article-title":"Pathways and mechanisms of endocytic recycling","volume":"10","author":"Grant","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.102094_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yexmp.2014.02.005","article-title":"Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1\u00df and TNF-\u03b1 in vitro","volume":"96","author":"Gruber","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.arr.2023.102094_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123479","article-title":"Exosome-laden injectable self-healing hydrogel based on quaternized chitosan and oxidized starch attenuates disc degeneration by suppressing nucleus pulposus senescence","volume":"232","author":"Guan","year":"2023","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2023.102094_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5542241","article-title":"Exosomal MATN3 of urine-derived stem cells ameliorates intervertebral disc degeneration by antisenescence effects and promotes NPC proliferation and ECM synthesis by activating TGF-\u03b2","volume":"2021","author":"Guo","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113961","article-title":"Dosing extracellular vesicles","volume":"178","author":"Gupta","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2023.102094_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1168","article-title":"The cellular response to extracellular vesicles is dependent on their cell source and dose","volume":"9","author":"Hagey","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2023.102094_bib52","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2174\/1574888X17666220628123912","article-title":"Overview of stem cell therapy in intervertebral disc disease: clinical perspective","volume":"18","author":"Hajiesmailpoor","year":"2023","journal-title":"Curr. Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2023.102094_bib53","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.3727\/096368915X688650","article-title":"Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies","volume":"24","author":"Han","year":"2015","journal-title":"Cell Transpl."},{"key":"10.1016\/j.arr.2023.102094_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.824771","article-title":"Single-Cell RNA sequencing of the nucleus pulposus reveals chondrocyte differentiation and regulation in intervertebral disc degeneration","volume":"10","author":"Han","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2023.102094_bib55","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.joca.2022.08.009","article-title":"Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism","volume":"30","author":"Hao","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.arr.2023.102094_bib56","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2023.102094_bib57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13287-021-02378-7","article-title":"Mesenchymal stem\/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities","volume":"12","author":"Hassanzadeh","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib58","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biotechadv.2017.11.009","article-title":"Innovative strategies for intervertebral disc regenerative medicine: From cell therapies to multiscale delivery systems","volume":"36","author":"Henry","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.arr.2023.102094_bib59","article-title":"Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures","volume":"11","author":"Hingert","year":"2020","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2023.102094_bib60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/SHK.0000000000001947","article-title":"Mechanism of MIR-25\u20133\u2009P Carried by extracellular vesicles derived from platelet-rich plasma in il-1\u03b2-induced nucleus pulposus cell degeneration via the sox4\/cxcr7 axis","volume":"58","author":"Hu","year":"2022","journal-title":"Shock"},{"key":"10.1016\/j.arr.2023.102094_bib61","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7538025","article-title":"Mesenchymal stem cell-derived extracellular vesicles: immunomodulatory effects and potential applications in intervertebral disc degeneration","volume":"2022","author":"Hu","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arr.2023.102094_bib62","article-title":"Mid- to long-term outcomes of cervical disc arthroplasty versus anterior cervical discectomy and fusion for treatment of symptomatic cervical disc disease: a systematic review and meta-analysis of eight prospective randomized controlled trials","volume":"11","author":"Hu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2023.102094_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2310025","article-title":"Exosomes derived from bone mesenchymal stem cells alleviate compression-induced nucleus pulposus cell apoptosis by inhibiting oxidative stress","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib64","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.actbio.2022.12.019","article-title":"Muscle-derived extracellular vesicles improve disuse-induced osteoporosis by rebalancing bone formation and bone resorption","volume":"157","author":"Huang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2023.102094_bib65","article-title":"Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration","volume":"13","author":"Huang","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.arr.2023.102094_bib66","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.spinee.2012.12.005","article-title":"The effects of microenvironment in mesenchymal stem cell-based regeneration of intervertebral disc","volume":"13","author":"Huang","year":"2013","journal-title":"Spine J."},{"key":"10.1016\/j.arr.2023.102094_bib67","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/00007632-199605150-00009","article-title":"Is the nucleus pulposus a solid or a fluid? mechanical behaviors of the nucleus pulposus of the human intervertebral disc","volume":"21","author":"Iatridis","year":"1996","journal-title":"Spine (Philos. Pa 1976)"},{"key":"10.1016\/j.arr.2023.102094_bib68","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1021\/acsnano.9b10033","article-title":"Endocytosis of extracellular vesicles and release of their cargo from endosomes","volume":"14","author":"Joshi","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2023.102094_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.arr.2023.102094_bib70","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2217\/17460751.3.5.717","article-title":"Strategies for regeneration of the intervertebral disc","volume":"3","author":"Kalson","year":"2008","journal-title":"Regen. Med"},{"issue":"Suppl 2","key":"10.1016\/j.arr.2023.102094_bib71","first-page":"21","article-title":"Lumbar disc disorders and low-back pain: socioeconomic factors and consequences","volume":"88","author":"Katz","year":"2006","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.arr.2023.102094_bib72","volume":"21","author":"Kim","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib73","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00701-008-1617-7","article-title":"The AdLMP-1 transfection in two different cells; AF cells, chondrocytes as potential cell therapy candidates for disc degeneration","volume":"150","author":"Kuh","year":"2008","journal-title":"Acta Neurochir. (Wien. )"},{"key":"10.1016\/j.arr.2023.102094_bib74","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13287-017-0710-3","article-title":"Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study","volume":"8","author":"Kumar","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8404168","article-title":"Inhibition of the notch1 pathway promotes the effects of nucleus pulposus cell-derived exosomes on the differentiation of mesenchymal stem cells into nucleus pulposus-like cells in rats","volume":"2019","author":"Lan","year":"2019","journal-title":"Stem Cells Int"},{"issue":"Suppl 2","key":"10.1016\/j.arr.2023.102094_bib76","first-page":"83","article-title":"Biologic modification of animal models of intervertebral disc degeneration","volume":"88","author":"Larson","year":"2006","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.arr.2023.102094_bib77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.spinee.2011.09.011","article-title":"Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model","volume":"12","author":"Leckie","year":"2012","journal-title":"Spine J."},{"key":"10.1016\/j.arr.2023.102094_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223589","article-title":"o-vanillin modulates cell phenotype and extracellular vesicles of human mesenchymal stem cells and intervertebral disc cells","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.arr.2023.102094_bib79","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.922928","article-title":"Exosomes derived from bone marrow mesenchymal stem cells prevent acidic pH-induced damage in human nucleus pulposus cells","volume":"26","author":"Li","year":"2020","journal-title":"Med Sci. Monit."},{"key":"10.1016\/j.arr.2023.102094_bib80","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1517\/14712598.2015.1051528","article-title":"Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy","volume":"15","author":"Li","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113408","article-title":"Bone mesenchymal stem cells deliver exogenous lncRNA CAHM via exosomes to regulate macrophage polarization and ameliorate intervertebral disc degeneration","volume":"421","author":"Li","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.arr.2023.102094_bib82","article-title":"Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2023.102094_bib83","article-title":"Exosomes and exosomal miRNAs: a new therapy for intervertebral disc degeneration","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.arr.2023.102094_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-023-00375-9","article-title":"Research progress on the role of extracellular vesicles in neurodegenerative diseases","volume":"12","author":"Li","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2023.102094_bib85","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.amjms.2020.07.025","article-title":"Human bone marrow mesenchymal stem cell-derived exosomes attenuate IL-1\u03b2-induced annulus fibrosus cell damage","volume":"360","author":"Li","year":"2020","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib86","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.7150\/thno.33638","article-title":"Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo","volume":"9","author":"Liao","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2023.102094_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120850","article-title":"Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration","volume":"274","author":"Liao","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2023.102094_bib88","doi-asserted-by":"crossref","first-page":"14709","DOI":"10.1021\/acsnano.1c04514","article-title":"Engineering extracellular vesicles restore the impaired cellular uptake and attenuate intervertebral disc degeneration","volume":"15","author":"Liao","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2023.102094_bib89","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01624-1","article-title":"Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system","volume":"20","author":"Liao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.956058","article-title":"Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: a bibliometric and visualized study","volume":"10","author":"Lin","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib91","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201903916","article-title":"Progress in microfluidics-based exosome separation and detection technologies for diagnostic applications","volume":"16","author":"Lin","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.arr.2023.102094_bib92","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41422-018-0070-2","article-title":"Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res"},{"key":"10.1016\/j.arr.2023.102094_bib93","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.biomaterials.2018.11.007","article-title":"Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis","volume":"192","author":"Liu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2023.102094_bib94","doi-asserted-by":"crossref","first-page":"16432","DOI":"10.1021\/acsnano.2c12857","article-title":"Engineered extracellular vesicle-delivered CRISPR\/Cas9 for radiotherapy sensitization of glioblastoma","volume":"17","author":"Liu","year":"2023","journal-title":"ACS nano"},{"key":"10.1016\/j.arr.2023.102094_bib95","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0563-9","article-title":"Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells","volume":"8","author":"Lu","year":"2017","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2023.102094_bib96","article-title":"Mesenchymal stem cell-derived exosomes as a novel strategy for the treatment of intervertebral disc degeneration","volume":"9","author":"Lu","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2023.102094_bib97","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.648201","article-title":"Cartilage endplate stem cells transdifferentiate into nucleus pulposus cells via autocrine exosomes","volume":"9","author":"Luo","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2023.102094_bib98","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/stem.3322","article-title":"Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt\/autophagy","volume":"39","author":"Luo","year":"2021","journal-title":"Stem Cells"},{"key":"10.1016\/j.arr.2023.102094_bib99","first-page":"29","article-title":"Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration","volume":"15","author":"Luo","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2023.102094_bib100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1631\/jzus.B1500182","article-title":"Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells","volume":"17","author":"Luo","year":"2016","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.arr.2023.102094_bib101","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3892\/ijmm.2015.2225","article-title":"Effect of lentivirus-mediated survivin transfection on the morphology and apoptosis of nucleus pulposus cells derived from degenerative human disc in vitro","volume":"36","author":"Ma","year":"2015","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.arr.2023.102094_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118002","article-title":"Adult mesenchymal stem cells and their exosomes: sources, characteristics, and application in regenerative medicine","volume":"256","author":"Maqsood","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2023.102094_bib103","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"Mari\u00f1o","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2023.102094_bib104","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s12079-021-00616-4","article-title":"Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans","volume":"15","author":"Matsushima","year":"2021","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.arr.2023.102094_bib105","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00264-018-4221-3","article-title":"Cervical disc herniation: which surgery?","volume":"43","author":"Mazas","year":"2019","journal-title":"Int Orthop."},{"key":"10.1016\/j.arr.2023.102094_bib106","article-title":"Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: a new therapeutic approach for intervertebral disc disorders","volume":"12","author":"Mern","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.arr.2023.102094_bib107","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.spinee.2006.04.014","article-title":"Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs","volume":"6","author":"Miyamoto","year":"2006","journal-title":"Spine J.: Off. J. North Am. Spine Soc."},{"key":"10.1016\/j.arr.2023.102094_bib108","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.joca.2013.12.008","article-title":"Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration","volume":"22","author":"Moon","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.arr.2023.102094_bib109","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-0036-1571955","article-title":"Biological treatment approaches for degenerative disk disease: a literature review of in vivo animal and clinical data","volume":"6","author":"Moriguchi","year":"2016","journal-title":"Glob. Spine J."},{"key":"10.1016\/j.arr.2023.102094_bib110","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s43440-020-00099-x","article-title":"Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats","volume":"72","author":"Nasr","year":"2020","journal-title":"Pharm. Rep."},{"key":"10.1016\/j.arr.2023.102094_bib111","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/946031","article-title":"Cell-based therapies used to treat lumbar degenerative disc disease: a systematic review of animal studies and human clinical trials","volume":"2015","author":"Oehme","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.arr.2023.102094_bib112","doi-asserted-by":"crossref","first-page":"E449","DOI":"10.1097\/BRS.0000000000001336","article-title":"PDGF-BB delays degeneration of the intervertebral discs in a rabbit preclinical model","volume":"41","author":"Paglia","year":"2016","journal-title":"Spine"},{"key":"10.1016\/j.arr.2023.102094_bib113","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.arr.2023.102094_bib114","doi-asserted-by":"crossref","first-page":"E525","DOI":"10.36076\/ppj.2014\/17\/E525","article-title":"Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain","author":"Pang","year":"2014","journal-title":"Pain. Physician 17"},{"key":"10.1016\/j.arr.2023.102094_bib115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s40610-018-0108-8","article-title":"Cellular senescence in intervertebral disc aging and degeneration","volume":"4","author":"Patil","year":"2018","journal-title":"Curr. Mol. Biol. Rep."},{"key":"10.1016\/j.arr.2023.102094_bib116","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/1947603519841675","article-title":"Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment","volume":"12","author":"Peck","year":"2021","journal-title":"Cartilage"},{"key":"10.1016\/j.arr.2023.102094_bib117","first-page":"4829","article-title":"Treatment with toll-like receptor 2 inhibitor ortho-vanillin alleviates lipopolysaccharide-induced acute kidney injury in mice","volume":"18","author":"Peng","year":"2019","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.arr.2023.102094_bib118","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206888","article-title":"Extracellular vesicle-conjugated functional matrix hydrogels prevent senescence by exosomal miR-3594-5p-targeted HIPK2\/p53 pathway for disc regeneration","author":"Peng","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.arr.2023.102094_bib119","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/ten.teb.2020.0196","article-title":"Putting the pieces in place: mobilizing cellular players to improve annulus fibrosus repair","volume":"27","author":"Peredo","year":"2021","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.arr.2023.102094_bib120","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/neuros\/nyy012","article-title":"Potential of human nucleus pulposus-like cells derived from umbilical cord to treat degenerative disc disease","volume":"84","author":"Perez-Cruet","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.arr.2023.102094_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00311","article-title":"Therapeutic potential of extracellular vesicles in degenerative diseases of the intervertebral disc","volume":"8","author":"Piazza","year":"2020","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib122","article-title":"Decellularized matrix for repairing intervertebral disc degeneration: fabrication methods, applications and animal models","volume":"18","author":"Qian","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.arr.2023.102094_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108962","article-title":"Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages","volume":"110","author":"Qian","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.arr.2023.102094_bib124","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/tra.12705","article-title":"Energetic adaptations: metabolic control of endocytic membrane traffic","volume":"20","author":"Rahmani","year":"2019","journal-title":"Traffic"},{"key":"10.1016\/j.arr.2023.102094_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091955","article-title":"Methods for separation and characterization of extracellular vesicles: results of a worldwide survey performed by the ISEV rigor and standardization subcommittee","volume":"9","author":"Royo","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2023.102094_bib126","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(07)60496-6","article-title":"Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study","volume":"369","author":"Ruan","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2023.102094_bib127","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.spinee.2023.03.008","article-title":"Obesity in children with low back pain: implications with imaging phenotypes and opioid use","volume":"23","author":"Rudisill","year":"2023","journal-title":"Spine J."},{"key":"10.1016\/j.arr.2023.102094_bib128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"S","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2023.102094_bib129","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nbt.2614","article-title":"Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling","volume":"31","author":"Sahay","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib130","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091974","article-title":"Nano-vesicle (mis)communication in senescence-related pathologies","volume":"9","author":"Saheera","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2023.102094_bib131","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","article-title":"Stem cell therapy for intervertebral disc regeneration: obstacles and solutions","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.arr.2023.102094_bib132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.addr.2014.06.009","article-title":"Advancing the cellular and molecular therapy for intervertebral disc disease","volume":"84","author":"Sakai","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2023.102094_bib133","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41434-018-0004-0","article-title":"Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review","volume":"25","author":"Sampara","year":"2018","journal-title":"Gene Ther."},{"key":"10.1016\/j.arr.2023.102094_bib134","doi-asserted-by":"crossref","DOI":"10.1177\/20417314231186918","article-title":"Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanism","volume":"14","author":"Shen","year":"2023","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.arr.2023.102094_bib135","article-title":"High-tech methods of cytokine imbalance correction in intervertebral disc degeneration","volume":"24","author":"Shnayder","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib136","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.biotechadv.2013.07.010","article-title":"Tissue engineering strategies applied in the regeneration of the human intervertebral disk","volume":"31","author":"Silva-Correia","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.arr.2023.102094_bib137","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-0830-4","article-title":"Influence of cholesterol\/caveolin-1\/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells","volume":"9","author":"Sohn","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib138","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.omtn.2020.07.039","article-title":"Exosome-transported circRNA_0000253 Competitively Adsorbs MicroRNA-141-5p and Increases IDD","volume":"21","author":"Song","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.arr.2023.102094_bib139","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.redox.2018.09.006","article-title":"Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration","volume":"19","author":"Song","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2023.102094_bib140","first-page":"2450","article-title":"Bone marrow mesenchymal stem cells-derived exosomal MiR-29b-3p regulates aging-associated insulin resistance","volume":"13","author":"Su","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2023.102094_bib141","first-page":"179","article-title":"A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction","volume":"6","author":"Sun","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2023.102094_bib142","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9955448","article-title":"Small extracellular vesicles derived from adipocytes attenuate intervertebral disc degeneration in rats by rejuvenating senescent nucleus pulposus cells and endplate cells by delivering exogenous NAMPT","volume":"2021","author":"Sun","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib143","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02362-1","article-title":"Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration","volume":"12","author":"Sun","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2023.102094_bib144","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.omtn.2020.10.021","article-title":"Notochordal-cell-derived exosomes induced by compressive load inhibit angiogenesis via the miR-140-5p\/Wnt\/\u03b2-catenin axis","volume":"22","author":"Sun","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.arr.2023.102094_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118778","article-title":"AF cell derived exosomes regulate endothelial cell migration and inflammation: Implications for vascularization in intervertebral disc degeneration","volume":"265","author":"Sun","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.arr.2023.102094_bib146","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.reth.2021.12.001","article-title":"Mesenchymal stem cell extracellular vesicles-derived microRNA-194-5p delays the development of intervertebral disc degeneration by targeting TRAF6","volume":"19","author":"Sun","year":"2022","journal-title":"Regen. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib147","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14245\/ns.2040042.021","article-title":"Gene therapy approach for intervertebral disc degeneration: an update","volume":"17","author":"Takeoka","year":"2020","journal-title":"Neurospine"},{"key":"10.1016\/j.arr.2023.102094_bib148","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-0797-1","article-title":"Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells","volume":"9","author":"Tang","year":"2018","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2023.102094_bib149","doi-asserted-by":"crossref","first-page":"90","DOI":"10.22203\/eCM.v041a07","article-title":"Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study","volume":"41","author":"Tang","year":"2021","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.arr.2023.102094_bib150","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/biof.1266","article-title":"Proportion of collagen type II in the extracellular matrix promotes the differentiation of human adipose-derived mesenchymal stem cells into nucleus pulposus cells","volume":"42","author":"Tao","year":"2016","journal-title":"Biofactors"},{"key":"10.1016\/j.arr.2023.102094_bib151","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1227\/NEU.0b013e318235d65f","article-title":"Bone morphogenetic proteins and degenerative disk disease","volume":"70","author":"Than","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.arr.2023.102094_bib152","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.arr.2023.102094_bib153","article-title":"Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry","volume":"9","author":"Tian","year":"2020","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.arr.2023.102094_bib154","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1152207","article-title":"Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro","volume":"11","author":"Tilotta","year":"2023","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib155","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1021\/acsnano.2c10351","article-title":"Augmenting intracellular cargo delivery of extracellular vesicles in hypoxic tissues through inhibiting hypoxia-induced endocytic recycling","volume":"17","author":"Tong","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2023.102094_bib156","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/nyas.13964","article-title":"Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies","volume":"1442","author":"Torre","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib157","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73991-4","article-title":"Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E\/\u03b2-thalassemia patient","volume":"10","author":"Trakarnsanga","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2023.102094_bib158","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.addr.2020.10.012","article-title":"Old drugs, new tricks\" - local controlled drug release systems for treatment of degenerative joint disease","volume":"160","author":"Tryfonidou","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2023.102094_bib159","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/term.1719","article-title":"Intervertebral disc regeneration: from the degenerative cascade to molecular therapy and tissue engineering","volume":"9","author":"Vadal\u00e0","year":"2015","journal-title":"J. Tissue Eng. Regen. Med"},{"key":"10.1016\/j.arr.2023.102094_bib160","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2023.102094_bib161","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2023.102094_bib162","article-title":"Low back pain","volume":"4","author":"Vlaeyen","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2023.102094_bib163","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/01.BRS.0000107231.67854.9F","article-title":"In vivo growth factor treatment of degenerated intervertebral discs","volume":"29","author":"Walsh","year":"2004","journal-title":"Spine (Philos. Pa 1976)"},{"key":"10.1016\/j.arr.2023.102094_bib164","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2164057","article-title":"miR-31 from mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration by inhibiting NFAT5 and Upregulating the Wnt\/\u03b2-Catenin Pathway","volume":"2022","author":"Wang","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arr.2023.102094_bib165","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.723220","article-title":"Human bone marrow mesenchymal stromal cell-derived extracellular vesicles promote proliferation of degenerated nucleus pulposus cells and the synthesis of extracellular matrix through the SOX4\/Wnt\/\u03b2-Catenin Axis","volume":"12","author":"Wang","year":"2021","journal-title":"Front Physiol."},{"key":"10.1016\/j.arr.2023.102094_bib166","article-title":"Global research status and hot trends in stem cells therapy for Intervertebral disc degeneration: a bibliometric and clinical study analysis","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.arr.2023.102094_bib167","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/cpr.12121","article-title":"Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies","volume":"47","author":"Wang","year":"2014","journal-title":"Cell Prolif."},{"key":"10.1016\/j.arr.2023.102094_bib168","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2022.08.018","article-title":"Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes","volume":"190","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2023.102094_bib169","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.789087","article-title":"AMPK as a potential therapeutic target for intervertebral disc degeneration","volume":"8","author":"Wang","year":"2021","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.arr.2023.102094_bib170","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/00007632-199705150-00008","article-title":"Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy","volume":"22","author":"Wehling","year":"1997","journal-title":"Spine"},{"key":"10.1016\/j.arr.2023.102094_bib171","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/15384101.2020.1863682","article-title":"Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a","volume":"20","author":"Wen","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2023.102094_bib172","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/j.pain.0000000000001396","article-title":"The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016","volume":"160","author":"Wu","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.arr.2023.102094_bib173","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1039\/C5AN00688K","article-title":"Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers","volume":"140","author":"Wu","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.arr.2023.102094_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.07.026","article-title":"Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects","volume":"143","author":"Xia","year":"2019","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.arr.2023.102094_bib175","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1019437","article-title":"Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration","volume":"10","author":"Xia","year":"2022","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib176","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6697577","article-title":"Exosomes derived from human urine-derived stem cells inhibit intervertebral disc degeneration by ameliorating endoplasmic reticulum stress","volume":"2020","author":"Xiang","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib177","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1089796","article-title":"Identification and validation of ferroptosis-related gene signature in intervertebral disc degeneration","volume":"14","author":"Xiang","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.arr.2023.102094_bib178","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9896444","article-title":"BMSC-derived exosomes alleviate intervertebral disc degeneration by modulating AKT\/mTOR-mediated autophagy of nucleus pulposus cells","volume":"2022","author":"Xiao","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arr.2023.102094_bib179","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.omtn.2020.09.026","article-title":"MSC-derived exosomes protect vertebral endplate chondrocytes against apoptosis and calcification via the miR-31-5p\/ATF6 Axis","volume":"22","author":"Xie","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.arr.2023.102094_bib180","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/os.13254","article-title":"Treatment of intervertebral disc degeneration","volume":"14","author":"Xin","year":"2022","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.arr.2023.102094_bib181","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-00991-5","article-title":"Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration","volume":"19","author":"Xing","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.arr.2023.102094_bib182","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/febs.13695","article-title":"BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration","volume":"283","author":"Xu","year":"2016","journal-title":"Febs J."},{"key":"10.1016\/j.arr.2023.102094_bib183","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1080\/15384101.2021.1949839","article-title":"Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes","volume":"20","author":"Xu","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2023.102094_bib184","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1172\/JCI81129","article-title":"Extracellular vesicle isolation and characterization: toward clinical application","volume":"126","author":"Xu","year":"2016","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2023.102094_bib185","article-title":"Mesenchymal stem cell-derived exosomes are beneficial to suppressing inflammation and promoting autophagy in intervertebral disc degeneration","author":"Yang","year":"2023","journal-title":"Folia Morphol. (Warsz. )"},{"key":"10.1016\/j.arr.2023.102094_bib186","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181708","article-title":"Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K\/Akt\/mTOR pathway in a hyperosmotic culture","volume":"38","author":"Yang","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.arr.2023.102094_bib187","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1530\/EOR-22-0083","article-title":"Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis","volume":"8","author":"Yao","year":"2023","journal-title":"EFORT Open Rev."},{"key":"10.1016\/j.arr.2023.102094_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109099","article-title":"Ascorbic acid promotes nucleus pulposus cell regeneration by regulating proliferation during intervertebral disc degeneration","volume":"108","author":"Yi","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.arr.2023.102094_bib189","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5483\/BMBRep.2014.47.10.164","article-title":"Extracellular vesicles as emerging intercellular communicasomes","volume":"47","author":"Yoon","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2023.102094_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101864","article-title":"MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis","volume":"85","author":"You","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2023.102094_bib191","article-title":"circ_0072464 shuttled by bone mesenchymal stem cell-secreted extracellular vesicles inhibits nucleus pulposus cell ferroptosis to relieve intervertebral disc degeneration","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib192","article-title":"Bone marrow mesenchymal stem cell-derived extracellular vesicles carrying circ_0050205 attenuate intervertebral disc degeneration","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2023.102094_bib193","article-title":"Human embryonic stem-cell-derived exosomes repress nlrp3 inflammasome to alleviate pyroptosis in nucleus pulposus cells by transmitting miR-302c","volume":"24","author":"Yu","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2023.102094_bib194","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1111\/jcmm.14268","article-title":"Apoptotic bodies from endplate chondrocytes enhance the oxidative stress-induced mineralization by regulating PPi metabolism","volume":"23","author":"Yuan","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.arr.2023.102094_bib195","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1089\/scd.2020.0083","article-title":"Exosomes derived from human placental mesenchymal stromal cells carrying antagomiR-4450 alleviate intervertebral disc degeneration through upregulation of ZNF121","volume":"29","author":"Yuan","year":"2020","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.arr.2023.102094_bib196","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-021-00355-7","article-title":"Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14\/NLRP3","volume":"27","author":"Yuan","year":"2021","journal-title":"Mol. Med"},{"key":"10.1016\/j.arr.2023.102094_bib197","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.blre.2012.12.002","article-title":"Extracellular vesicles in physiological and pathological conditions","volume":"27","author":"Yuana","year":"2013","journal-title":"Blood Rev."},{"key":"10.1016\/j.arr.2023.102094_bib198","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41584-022-00783-7","article-title":"Mechanisms and clinical implications of intervertebral disc calcification","volume":"18","author":"Zehra","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.arr.2023.102094_bib199","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gendis.2014.07.001","article-title":"Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine","volume":"1","author":"Zhang","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.arr.2023.102094_bib200","doi-asserted-by":"crossref","first-page":"11742","DOI":"10.1111\/jcmm.15784","article-title":"Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.arr.2023.102094_bib201","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9563693","article-title":"Intradiscal autologous platelet-rich plasma injection for discogenic low back pain: a clinical trial","volume":"2022","author":"Zhang","year":"2022","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.arr.2023.102094_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110083","article-title":"Exosomes miR-15a promotes nucleus pulposus-mesenchymal stem cells chondrogenic differentiation by targeting MMP-3","volume":"86","author":"Zhang","year":"2021","journal-title":"Cell Signal"},{"key":"10.1016\/j.arr.2023.102094_bib203","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/jor.24880","article-title":"Autophagy-activated nucleus pulposus cells deliver exosomal miR-27a to prevent extracellular matrix degradation by targeting MMP-13","volume":"39","author":"Zhang","year":"2021","journal-title":"J. Orthop. Res"},{"key":"10.1016\/j.arr.2023.102094_bib204","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.21037\/atm-21-227","article-title":"TNF-\u03b1-stimulated nucleus pulposus cells induce cell apoptosis through the release of exosomal miR-16 targeting IGF-1 and IGF-1R in rats","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.arr.2023.102094_bib205","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s11095-009-9897-z","article-title":"Nanoparticulate systems for growth factor delivery","volume":"26","author":"Zhang","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.arr.2023.102094_bib206","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13287-022-02745-y","article-title":"Application of stem cells in the repair of intervertebral disc degeneration","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2023.102094_bib207","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.freeradbiomed.2020.08.029","article-title":"Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4","volume":"160","author":"Zhang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2023.102094_bib208","first-page":"8031","article-title":"New strategies for the treatment of intervertebral disc degeneration: cell, exosome, gene, and tissue engineering","volume":"14","author":"Zhang","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.arr.2023.102094_bib209","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.arr.2023.102094_bib210","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2021.10866","article-title":"Influence of extracellular nanovesicles derived from adipose-derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration","volume":"22","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.arr.2023.102094_bib211","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.mehy.2008.11.002","article-title":"The possible process of neovascularization in degeneration intervertebral disc","volume":"72","author":"Zhao","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.arr.2023.102094_bib212","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.7150\/thno.45359","article-title":"Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2023.102094_bib213","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.actbio.2018.03.019","article-title":"Genipin cross-linked type II collagen\/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus","volume":"71","author":"Zhou","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2023.102094_bib214","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.actbio.2021.11.044","article-title":"Small extracellular vesicles from hypoxic mesenchymal stem cells alleviate intervertebral disc degeneration by delivering miR-17-5p","volume":"140","author":"Zhou","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2023.102094_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112109","article-title":"Exosomal miR-532-5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5","volume":"393","author":"Zhu","year":"2020","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.arr.2023.102094_bib216","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/15384101.2020.1769301","article-title":"Mesenchymal stem cells-derived exosomes ameliorate nucleus pulposus cells apoptosis via delivering miR-142-3p: therapeutic potential for intervertebral disc degenerative diseases","volume":"19","author":"Zhu","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2023.102094_bib217","article-title":"Exosomes secreted by nucleus pulposus stem cells derived from degenerative intervertebral disc exacerbate annulus fibrosus cell degradation via Let-7b-5p","volume":"8","author":"Zhuang","year":"2021","journal-title":"Front Mol. Biosci."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723002532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163723002532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:12:43Z","timestamp":1761592363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163723002532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":217,"alternative-id":["S1568163723002532"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2023.102094","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2023.102094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102094"}}