{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:27:38Z","timestamp":1793312858401,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2018FE001(-085)"],"award-info":[{"award-number":["2018FE001(-085)"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2018FE001"],"award-info":[{"award-number":["2018FE001"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.arr.2024.102223","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T11:48:19Z","timestamp":1707133699000},"page":"102223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Unveiling the role of astrocytes in postoperative cognitive dysfunction"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-4072","authenticated-orcid":false,"given":"Liang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102223_bib1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s11064-022-03771-1","article-title":"Glial glutamine homeostasis in health and disease","volume":"48","author":"Andersen","year":"2023","journal-title":"Neurochem Res"},{"key":"10.1016\/j.arr.2024.102223_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.15811","article-title":"Milestone review: metabolic dynamics of glutamate and gaba mediated neurotransmission - the essential roles of astrocytes","author":"Andersen","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2024.102223_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102199","article-title":"Reactive astrocytes prevent maladaptive plasticity after ischemic stroke","volume":"209","author":"Aswendt","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2024.102223_bib4","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1523\/JNEUROSCI.1376-23.2023","article-title":"Astrocytes as drivers and disruptors of behavior: new advances in basic mechanisms and therapeutic targeting","volume":"43","author":"Barnett","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib5","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1007\/s12035-021-02530-7","article-title":"Lipocalin 2 as a putative modulator of local inflammatory processes in the spinal cord and component of organ cross talk after spinal cord injury","volume":"58","author":"Behrens","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102223_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/acn3.51499","article-title":"Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers","volume":"9","author":"Berger","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.arr.2024.102223_bib7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/glia.20618","article-title":"The ANP-cGMP-protein kinase G pathway induces a phagocytic phenotype but decreases inflammatory gene expression in microglial cells","volume":"56","author":"Bor\u00e1n","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.arr.2024.102223_bib8","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1038\/s41380-021-01193-z","article-title":"Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using (11)C-BU99008 PET and its relationship with amyloid load","volume":"26","author":"Calsolaro","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2024.102223_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2017.09.004","article-title":"Hypoxia-inducible factor-1\u03b1 is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD","volume":"339","author":"Cao","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2024.102223_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215372","article-title":"Structure and junctional complexes of endothelial, epithelial and glial brain barriers","volume":"20","author":"Castro Dias","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102223_bib11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2024.102223_bib12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbi.2019.01.020","article-title":"MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice","volume":"78","author":"Chen","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ymthe.2019.09.003","article-title":"A neuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.arr.2024.102223_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12974-021-02150-x","article-title":"Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1\/R1 signaling","volume":"18","author":"Cho","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.5607\/en.2018.27.6.564","article-title":"Siegesbeckia orientalis L. extract attenuates postoperative cognitive dysfunction, systemic inflammation, and neuroinflammation","volume":"27","author":"Chu","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.arr.2024.102223_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbr.2016.08.027","article-title":"Neuroinflammatory challenges compromise neuronal function in the aging brain: postoperative cognitive delirium and Alzheimer's disease","volume":"322","author":"Cortese","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2024.102223_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ALN.0000000000002729","article-title":"Postoperative delirium and postoperative cognitive dysfunction: overlap and divergence","volume":"131","author":"Daiello","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arr.2024.102223_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbi.2016.07.157","article-title":"Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria","volume":"58","author":"Dalko","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"ATP mediates rapid microglial response to local brain injury in vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/glia.24294","article-title":"The multitaskers of the brain: Glial responses to viral infections and associated post-infectious neurologic sequelae","volume":"71","author":"Dave","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.arr.2024.102223_bib21","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2023.0907","article-title":"Microglia and astrocytes in Alzheimer's disease: significance and summary of recent advances","author":"Deng","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2024.102223_bib22","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.0500989102","article-title":"Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury","volume":"102","author":"Di Giovanni","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2024.102223_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-022-02424-y","article-title":"Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice","volume":"19","author":"Dong","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.adc9020","article-title":"Molecular basis of astrocyte diversity and morphology across the CNS in health and disease","volume":"378","author":"Endo","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.arr.2024.102223_bib25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bja.2017.11.087","article-title":"Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018","volume":"121","author":"Evered","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.arr.2024.102223_bib26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","article-title":"Postoperative cognitive dysfunction and noncardiac surgery","volume":"127","author":"Evered","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.arr.2024.102223_bib27","first-page":"1541","article-title":"Neurotropin reduces memory impairment and neuroinflammation via BDNF\/NF-kappaB in a transgenic mouse model of Alzheimer's disease","volume":"11","author":"Fang","year":"2019","journal-title":"Am. J. Transl. Res"},{"key":"10.1016\/j.arr.2024.102223_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fphys.2020.00871","article-title":"Sodium fluctuations in astroglia and their potential impact on astrocyte function","volume":"11","author":"Felix","year":"2020","journal-title":"Front Physiol."},{"key":"10.1016\/j.arr.2024.102223_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2023.04.006","article-title":"Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration","author":"Festa","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2024.102223_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.682460","article-title":"A computational study of astrocytic GABA release at the glutamatergic synapse: EAAT-2 and GAT-3 coupled dynamics","volume":"15","author":"Flanagan","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib31","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2044.2010.06244.x","article-title":"Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease","volume":"65","author":"Fodale","year":"2010","journal-title":"Anaesthesia"},{"key":"10.1016\/j.arr.2024.102223_bib32","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1523\/JNEUROSCI.4267-13.2014","article-title":"Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination","volume":"34","author":"Fulmer","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib33","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/acschemneuro.2c00791","article-title":"Synthesis and pharmacological characterization of a difluorinated analogue of reduced haloperidol as a sigma-1 receptor ligand","volume":"14","author":"Gao","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib34","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12035-013-8460-4","article-title":"Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury","volume":"48","author":"Gao","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102223_bib35","article-title":"Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: a meta-analysis and trial sequential analysis of prospective clinical trials","author":"Geng","year":"2023","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.arr.2024.102223_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101039","article-title":"Astrocyte mitochondria: central players and potential therapeutic targets for neurodegenerative diseases and injury","volume":"59","author":"Gollihue","year":"2020","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2024.102223_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.960657","article-title":"A crosstalk between circular RNA, microRNA, and messenger RNA in the development of various brain cognitive disorders","volume":"15","author":"He","year":"2022","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166992","article-title":"The role of astrocyte in neuroinflammation in traumatic brain injury","volume":"1870","author":"He","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2024.102223_bib39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbi.2014.06.203","article-title":"Toll-like receptors in central nervous system injury and disease: a focus on the spinal cord","volume":"42","author":"Heiman","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44667","article-title":"Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1","volume":"8","author":"Holt","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.arr.2024.102223_bib41","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2016.02.003","article-title":"Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same","volume":"54","author":"Hovens","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/jnc.13569","article-title":"The role of the Wnt\/\u03b2-catenin-Annexin A1 pathway in the process of sevoflurane-induced cognitive dysfunction","volume":"137","author":"Hu","year":"2016","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2024.102223_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbi.2022.09.002","article-title":"Transfer of neuron-derived \u03b1-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1","volume":"106","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2018.09.002","article-title":"Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis","volume":"133","author":"Ishii","year":"2019","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.arr.2024.102223_bib45","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s13238-017-0449-8","article-title":"Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity","volume":"9","author":"Jing","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.arr.2024.102223_bib46","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1523\/JNEUROSCI.2534-16.2017","article-title":"Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation","volume":"37","author":"Jo","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bbi.2020.03.011","article-title":"AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice","volume":"87","author":"Kim","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2022.11.014","article-title":"Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38\/MAPK signaling after TBI and prevent chronic brain dysfunction","volume":"108","author":"Kodali","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001747","article-title":"Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex","volume":"12","author":"Lalo","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2024.102223_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/7272456","article-title":"Downregulation of Nrf2 in the hippocampus contributes to postoperative cognitive dysfunction in aged rats by sensitizing oxidative stress and neuroinflammation","volume":"2023","author":"Li","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102223_bib51","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41380-021-01394-6","article-title":"Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism","volume":"27","author":"Lindholm","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2024.102223_bib52","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/s41380-021-01332-6","article-title":"Distinct roles of astroglia and neurons in synaptic plasticity and memory","volume":"27","author":"Liu","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2024.102223_bib53","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fimmu.2020.01024","article-title":"Interaction of Microglia and Astrocytes in the Neurovascular Unit","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2024.102223_bib54","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1177\/0300060519860026","article-title":"Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction","volume":"47","author":"Liu","year":"2019","journal-title":"J. Int Med Res"},{"key":"10.1016\/j.arr.2024.102223_bib55","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-220698","article-title":"The dual role of astrocyte-derived exosomes and their contents in the process of Alzheimer's disease","volume":"91","author":"Liu","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102223_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbi.2014.10.011","article-title":"S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4\/MyD88 pathway","volume":"44","author":"Lu","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib57","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12974-022-02519-6","article-title":"Perivascular macrophages in high-fat diet-induced hypothalamic inflammation","volume":"19","author":"Mendes","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejphar.2003.08.078","article-title":"Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations","volume":"479","author":"Mennini","year":"2003","journal-title":"Eur. J. Pharm.acol"},{"key":"10.1016\/j.arr.2024.102223_bib59","first-page":"686","article-title":"Postoperative delirium and neurocognitive disorders","volume":"27","author":"Migirov","year":"2021","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.arr.2024.102223_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12101856","article-title":"Optogenetics in Alzheimer's disease: focus on astrocytes","volume":"12","author":"Mitroshina","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102223_bib61","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(97)07382-0","article-title":"Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction","volume":"351","author":"Moller","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2024.102223_bib62","doi-asserted-by":"crossref","first-page":"i115","DOI":"10.1093\/bja\/aex354","article-title":"Postoperative cognitive dysfunction and dementia: what we need to know and do","volume":"119","author":"Needham","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.arr.2024.102223_bib63","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bbi.2018.07.016","article-title":"Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats","volume":"73","author":"Netto","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102223_bib64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2017.76","article-title":"Single-cell RNA sequencing to explore immune cell heterogeneity","volume":"18","author":"Papalexi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2024.102223_bib65","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2024.102223_bib66","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade","volume":"145","author":"Paumier","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.arr.2024.102223_bib67","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2174\/1566524023666221118140523","article-title":"Current progress on neuroinflammation-mediated postoperative cognitive dysfunction: an update","volume":"23","author":"Peng","year":"2023","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.arr.2024.102223_bib68","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1144640","article-title":"Astrocytes potentiate transmitter release at single hippocampal synapses","volume":"317","author":"Perea","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.arr.2024.102223_bib69","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13334","article-title":"Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity","volume":"20","author":"Popov","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102223_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101335","article-title":"Reactive astrocytes: the nexus of pathological and clinical hallmarks of Alzheimer's disease","volume":"68","author":"Price","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2024.102223_bib71","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","article-title":"Exploring tissue architecture using spatial transcriptomics","volume":"596","author":"Rao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102223_bib72","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/glia.23573","article-title":"Astrocyte-targeted IL-10 production decreases proliferation and induces a downregulation of activated microglia\/macrophages after PPT","volume":"67","author":"Recasens","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.arr.2024.102223_bib73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12640-022-00625-0","article-title":"L-2-hydroxyglutaric acid administration to neonatal rats elicits marked neurochemical alterations and long-term neurobehavioral disabilities mediated by oxidative stress","volume":"41","author":"Ribeiro","year":"2023","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2024.102223_bib74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41593-018-0325-8","article-title":"Astrocyte function from information processing to cognition and cognitive impairment","volume":"22","author":"Santello","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111474","article-title":"Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process","volume":"41","author":"Sapkota","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2024.102223_bib76","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.tins.2022.06.009","article-title":"Foundations and implications of astrocyte heterogeneity during brain development and disease","volume":"45","author":"Schober","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib77","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0079-6123(08)61751-3","article-title":"Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA","author":"Schousboe","year":"1992","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.arr.2024.102223_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2022.577951","article-title":"The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation","volume":"371","author":"Serna-Rodr\u00edguez","year":"2022","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2024.102223_bib79","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib80","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","article-title":"Long-term consequences of postoperative cognitive dysfunction","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arr.2024.102223_bib81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/neu.2012.2488","article-title":"Purinergic 2Y1 receptor stimulation decreases cerebral edema and reactive gliosis in a traumatic brain injury model","volume":"30","author":"Talley Watts","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.arr.2024.102223_bib82","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exger.2016.11.004","article-title":"Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline","volume":"94","author":"Tarantini","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2024.102223_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer's disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.arr.2024.102223_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/402959","article-title":"Biomarkers of brain damage and postoperative cognitive disorders in orthopedic patients: An update","volume":"2015","author":"Tomaszewski","year":"2015","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.arr.2024.102223_bib85","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0165-5728(99)00187-3","article-title":"Interleukin-6 expression and regulation in astrocytes","volume":"100","author":"Van Wagoner","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2024.102223_bib86","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2010-101089","article-title":"Astrocytes in Alzheimer's disease: emerging roles in calcium dysregulation and synaptic plasticity","volume":"22","author":"Vincent","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102223_bib87","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.2174\/138161212803832344","article-title":"Neurotoxicity of general anesthetics: an update","volume":"18","author":"Vlisides","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2024.102223_bib88","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/jcbfm.2010.115","article-title":"Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine","volume":"31","author":"Walls","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.arr.2024.102223_bib89","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12974-020-01976-1","article-title":"Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Abeta-exposed U251 cells and APP\/PS1 mice","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejphar.2018.12.034","article-title":"Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus","volume":"846","author":"Wang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.arr.2024.102223_bib91","article-title":"Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2024.102223_bib92","article-title":"Postoperative cognitive dysfunction and Alzheimer's disease: a transcriptome-based comparison of animal models","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib93","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1523\/JNEUROSCI.1377-22.2022","article-title":"Amplified gliosis and interferon-associated inflammation in the aging brain following diffuse traumatic brain injury","volume":"42","author":"Wangler","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2024.102223_bib94","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13287-022-03232-0","article-title":"Neuroblasts migration under control of reactive astrocyte-derived BDNF: a promising therapy in late neurogenesis after traumatic brain injury","volume":"14","author":"Wu","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.arr.2024.102223_bib95","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3233\/JAD-230199","article-title":"Microglia-astrocyte communication in Alzheimer's disease","volume":"95","author":"Wu","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102223_bib96","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.exger.2006.01.014","article-title":"Alzheimer's disease and post-operative cognitive dysfunction","volume":"41","author":"Xie","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2024.102223_bib97","article-title":"Peripheral surgical wounding and age-dependent neuroinflammation in mice","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2024.102223_bib98","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s12035-022-02739-0","article-title":"N6-methyladenosine and Neurological Diseases","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102223_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12974-016-0782-5","article-title":"Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period","volume":"14","author":"Zhu","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102223_bib100","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s13311-023-01360-w","article-title":"Memantine\/Aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal CREB\/BDNF signaling and glutamate homeostasis","volume":"20","author":"Zohny","year":"2023","journal-title":"Neurotherapeutics"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724000412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724000412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:58:15Z","timestamp":1762552695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724000412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":100,"alternative-id":["S1568163724000412"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102223","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the role of astrocytes in postoperative cognitive dysfunction","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102223"}}