{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:41:17Z","timestamp":1788194477814,"version":"build-2803163510"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005758","name":"Universit\u00e0 Politecnica delle Marche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.arr.2024.102257","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T07:17:36Z","timestamp":1709363856000},"page":"102257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Circulating biomarkers of inflammaging and Alzheimer\u2019s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?"],"prefix":"10.1016","volume":"96","author":[{"given":"Angela Marie","family":"Abbatecola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-8519","authenticated-orcid":false,"given":"Angelica","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Biscetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Scisciola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronilla","family":"Battista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangela","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Sabbatinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102257_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41591-019-0381-y","article-title":"A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring","volume":"25","author":"Alpert","year":"2019","journal-title":"Nat. Med"},{"key":"10.1016\/j.arr.2024.102257_bib2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neurobiolaging.2006.02.012","article-title":"Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease","volume":"28","author":"Alvarez","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3233\/JAD-160573","article-title":"Cerebrospinal fluid biomarkers for alzheimer's disease: a view of the regulatory science qualification landscape from the coalition against major diseases CSF biomarker team","volume":"55","author":"Arneric","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib4","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/acn3.51670","article-title":"Comparison of plasma and CSF biomarkers in predicting cognitive decline","volume":"9","author":"Aschenbrenner","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib5","article-title":"The relation between inflammation and neuropsychological test performance","volume":"2012","author":"Balldin","year":"2012","journal-title":"Int J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib6","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/acn3.51234","article-title":"Blood neurofilament light: a critical review of its application to neurologic disease","volume":"7","author":"Barro","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease","volume":"26","author":"Barthelemy","year":"2020","journal-title":"Nat. Med"},{"key":"10.1016\/j.arr.2024.102257_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2024.102257_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13195-022-01094-5","article-title":"Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer's disease and frontotemporal lobar degeneration","volume":"14","author":"Benussi","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2024.102257_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.dadm.2016.05.004","article-title":"MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes","volume":"3","author":"Bettcher","year":"2016","journal-title":"Alzheimers Dement (Amst."},{"key":"10.1016\/j.arr.2024.102257_bib11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbi.2022.12.015","article-title":"GDF15 and its association with cognitive performance over time in a longitudinal study of middle-aged urban adults","volume":"108","author":"Beydoun","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102257_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/bs.pmbts.2019.07.006","article-title":"Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings","volume":"168","author":"Blennow","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.arr.2024.102257_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-220318","article-title":"A Combination of neurofilament light, glial fibrillary acidic protein, and neuronal pentraxin-2 discriminates between frontotemporal dementia and other dementias","volume":"90","author":"Bolsewig","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2017.11.009","article-title":"Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance","volume":"63","author":"Bradburn","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13195-022-01117-1","article-title":"The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease: a literature review","volume":"14","author":"Brand","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2024.102257_bib16","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/alz.12301","article-title":"Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study","volume":"17","author":"Brickman","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s43587-023-00471-5","article-title":"A two-step workflow based on plasma p-tau217 to screen for amyloid beta positivity with further confirmatory testing only in uncertain cases","volume":"3","author":"Brum","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib18","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.neurobiolaging.2008.10.012","article-title":"Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment.","volume":"31","author":"Buchhave","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41398-020-01137-1","article-title":"Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease","volume":"11","author":"Chatterjee","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.arr.2024.102257_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.566922","article-title":"Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases","volume":"12","author":"Chen","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102257_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13955","article-title":"Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort","volume":"22","author":"Chen","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102257_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101569","article-title":"GDF15, an emerging key player in human aging","volume":"75","author":"Conte","year":"2022","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2024.102257_bib23","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1111\/bph.14586","article-title":"Neutralization of IL-17 rescues amyloid-beta-induced neuroinflammation and memory impairment.","volume":"176","author":"Cristiano","year":"2019","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.arr.2024.102257_bib24","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41467-021-23746-0","article-title":"Plasma biomarkers of Alzheimer's disease improve prediction of cognitive decline in cognitively unimpaired elderly populations","volume":"12","author":"Cullen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2024.102257_bib25","article-title":"Longitudinal associations of serum biomarkers with early cognitive, amyloid and grey matter changes","author":"De Meyer","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.arr.2024.102257_bib26","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/alz.12545","article-title":"Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview","volume":"18","author":"Delaby","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/JAD-200828","article-title":"Plasma biomarkers of Alzheimer's disease in African Americans","volume":"79","author":"Deniz","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.neurobiolaging.2006.10.019","article-title":"Enhanced soluble CD40 ligand and Alzheimer's disease: evidence of a possible pathogenetic role","volume":"29","author":"Desideri","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib29","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3233\/JAD-2010-100921","article-title":"Higher serum sTNFR1 level predicts conversion from mild cognitive impairment to Alzheimer's disease","volume":"22","author":"Diniz","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib31","doi-asserted-by":"crossref","unstructured":"Foley, K.E., Winder, Z., Sudduth, T.L., Martin, B.J., Nelson, P.T., Jicha, G.A., Harp, J.P., Weekman, E.M. and Wilcock, D.M., 2023. Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort. Alzheimers Dement.","DOI":"10.1002\/alz.13485"},{"key":"10.1016\/j.arr.2024.102257_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.arr.2024.102257_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12974-022-02446-6","article-title":"The role of Th17 cells\/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A","volume":"19","author":"Fu","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102257_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.smim.2018.09.003","article-title":"The integration of inflammaging in age-related diseases","volume":"40","author":"Fulop","year":"2018","journal-title":"Semin Immunol."},{"key":"10.1016\/j.arr.2024.102257_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12979-017-0106-3","article-title":"The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: the HUNT study, Norway","volume":"15","author":"Gabin","year":"2018","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2024.102257_bib36","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/brain\/awaa098","article-title":"Neurofilaments: neurobiological foundations for biomarker applications","volume":"143","author":"Gafson","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.arr.2024.102257_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102046","article-title":"Novel fluid biomarkers for mild cognitive impairment: a systematic review and meta-analysis","volume":"91","author":"Gaur","year":"2023","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2024.102257_bib38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13195-022-01058-9","article-title":"Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer's disease","volume":"14","author":"Giannisis","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2024.102257_bib39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/1533317515602087","article-title":"A meta-analysis of c-reactive protein in patients with Alzheimer's disease","volume":"31","author":"Gong","year":"2016","journal-title":"Am. J. Alzheimers Dis. Other Demen"},{"key":"10.1016\/j.arr.2024.102257_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111589","article-title":"A geroscience motivated approach to treat Alzheimer's disease: senolytics move to clinical trials","volume":"200","author":"Gonzales","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102257_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158453","article-title":"Biological aging processes underlying cognitive decline and neurodegenerative disease","volume":"132","author":"Gonzales","year":"2022","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2024.102257_bib42","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat. Med"},{"key":"10.1016\/j.arr.2024.102257_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e13972","article-title":"Serum levels of IL-6 are associated with cognitive impairment in the salus in apulia population-based study","volume":"9","author":"Griseta","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.arr.2024.102257_bib44","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2024.102257_bib45","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","article-title":"Cellular senescence at the crossroads of inflammation and Alzheimer's disease","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2024.102257_bib46","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jalz.2018.01.010","article-title":"CSF biomarkers of Alzheimer's disease concord with amyloid-beta PET and predict clinical progression: a study of fully automated immunoassays in BioFINDER and ADNI cohorts.","volume":"14","author":"Hansson","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib47","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12974-018-1376-1","article-title":"Circulating levels of IL-1 family cytokines and receptors in Alzheimer's disease: new markers of disease progression?","volume":"15","author":"Italiani","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102257_bib48","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2024.102257_bib49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib50","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/brain\/awac333","article-title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease","volume":"146","author":"Janelidze","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.arr.2024.102257_bib51","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1056\/NEJMoa2310168","article-title":"Biomarker changes during 20 years preceding Alzheimer's disease","volume":"390","author":"Jia","year":"2024","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.arr.2024.102257_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2023.107773","article-title":"IL-33\/ST2 signaling pathway and Alzheimer's disease: a systematic review and meta-analysis","volume":"230","author":"Jiang","year":"2023","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.arr.2024.102257_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1177611","article-title":"Small immunological clocks identified by deep learning and gradient boosting","volume":"14","author":"Kalyakulina","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2024.102257_bib54","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern Med"},{"key":"10.1016\/j.arr.2024.102257_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3233\/JAD-143189","article-title":"Characterizing aging, mild cognitive impairment, and dementia with blood-based biomarkers and neuropsychology","volume":"50","author":"Kleinschmidt","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1172\/JCI66771","article-title":"CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model","volume":"125","author":"Krauthausen","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2024.102257_bib57","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1016\/S2666-7568(23)00098-3","article-title":"Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort","volume":"4","author":"Krogseth","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.arr.2024.102257_bib58","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s43587-023-00491-1","article-title":"The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology","volume":"3","author":"Lau","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111585","article-title":"A guide to senolytic intervention in neurodegenerative disease","volume":"200","author":"Lee","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102257_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13256","article-title":"Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging","volume":"19","author":"Lehallier","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102257_bib61","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1038\/s41467-023-39873-9","article-title":"Platelet-derived exerkine CXCL4\/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice","volume":"14","author":"Leiter","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2024.102257_bib62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13195-020-00652-z","article-title":"The role of interleukin-33 in patients with mild cognitive impairment and Alzheimer's disease","volume":"12","author":"Liang","year":"2020","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2024.102257_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.670115","article-title":"Better identification of cognitive decline with interleukin-2 than with amyloid and tau protein biomarkers in amnestic mild cognitive impairment","volume":"13","author":"Liang","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102257_bib64","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0197-4580(95)00056-K","article-title":"Serum alpha 1-antichymotrypsin level as a marker for Alzheimer-type dementia","volume":"16","author":"Lieberman","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib65","unstructured":"Long, S., Benoist, C. and Weidner, W., 2023. World Alzheimer Report 2023: Reducing dementia risk: never too early, never too late. London, England: Alzheimer\u2019s Disease International."},{"key":"10.1016\/j.arr.2024.102257_bib66","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102257_bib67","doi-asserted-by":"crossref","unstructured":"Lu, W.H., Guyonnet, S., Martinez, L.O., Lucas, A., Parini, A., Vellas, B. and de Souto Barreto, P., 2023. Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults. Geroscience.","DOI":"10.1007\/s11357-023-00906-2"},{"key":"10.1016\/j.arr.2024.102257_bib68","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-021-01349-z","article-title":"Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease","volume":"11","author":"Lyra","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.arr.2024.102257_bib69","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-023-12148-5","article-title":"Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort","author":"Mendes","year":"2024","journal-title":"J. Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib70","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3233\/JAD-221287","article-title":"Associations of midlife lifestyle and health factors with long-term changes in blood-based biomarkers of Alzheimer's disease and neurodegeneration","volume":"94","author":"Merten","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib71","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jalz.2018.02.013","article-title":"Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography","volume":"14","author":"Mielke","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110521","article-title":"Immunosenescence as a convergence pathway in neurodegeneration","volume":"121","author":"Mohapatra","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.arr.2024.102257_bib73","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1016\/j.cell.2023.08.003","article-title":"Biomarkers of aging for the identification and evaluation of longevity interventions","volume":"186","author":"Moqri","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102257_bib74","doi-asserted-by":"crossref","unstructured":"Morgan, A.R., Touchard, S., Leckey, C., O\u2019Hagan, C., Nevado-Holgado, A.J., Consortium, N., Barkhof, F., Bertram, L., Blin, O., Bos, I., Dobricic, V., Engelborghs, S., Frisoni, G., Frolich, L., Gabel, S., Johannsen, P., Kettunen, P., Kloszewska, I., Legido-Quigley, C., Lleo, A., Martinez-Lage, P., Mecocci, P., Meersmans, K., Molinuevo, J.L., Peyratout, G., Popp, J., Richardson, J., Sala, I., Scheltens, P., Streffer, J., Soininen, H., Tainta-Cuezva, M., Teunissen, C., Tsolaki, M., Vandenberghe, R., Visser, P.J., Vos, S.,Wahlund, L.O., Wallin, A., Westwood, S., Zetterberg, H., Lovestone, S., Morgan, B.P., 2019. Inflammatory biomarkers in Alzheimer\u2019s disease plasma. Alzheimers Dement. 15, 776\u2013787.","DOI":"10.1016\/j.jalz.2019.03.007"},{"key":"10.1016\/j.arr.2024.102257_bib75","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/d41573-023-00083-z","article-title":"NfL makes regulatory debut as neurodegenerative disease biomarker","volume":"22","author":"Mullard","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2024.102257_bib76","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/gerona\/glx144","article-title":"Measures of biologic age in a community sample predict mortality and age-related disease: the framingham offspring study","volume":"73","author":"Murabito","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"key":"10.1016\/j.arr.2024.102257_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102257_bib78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High performance plasma amyloid-beta biomarkers for Alzheimer's disease.","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102257_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30487-6","article-title":"IL-1beta, IL-6, TNF- alpha and CRP in elderly patients with depression or Alzheimer's disease: systematic review and meta-analysis","volume":"8","author":"Ng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2024.102257_bib80","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/s41591-022-02049-x","article-title":"Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline","volume":"28","author":"Ossenkoppele","year":"2022","journal-title":"Nat. Med"},{"key":"10.1016\/j.arr.2024.102257_bib81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2022.05.006","article-title":"Causal effects of circulating cytokine concentrations on risk of Alzheimer's disease and cognitive function","volume":"104","author":"Pagoni","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2024.102257_bib82","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3233\/ADR-230029","article-title":"Plasma Biomarkers of Alzheimer's Disease: A Review of Available Assays, Recent Developments, and Implications for Clinical Practice","volume":"7","author":"Pais","year":"2023","journal-title":"J. Alzheimers Dis. Rep."},{"key":"10.1016\/j.arr.2024.102257_bib83","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2024.102257_bib84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5483\/BMBRep.2020.53.1.309","article-title":"Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review","volume":"53","author":"Park","year":"2020","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2024.102257_bib85","doi-asserted-by":"crossref","first-page":"11","DOI":"10.30773\/pi.2020.0205","article-title":"The association of blood-based inflammatory factors IL-1beta, TGF-beta and CRP with cognitive function in Alzheimer's Disease and mild cognitive impairment","volume":"18","author":"Park","year":"2021","journal-title":"Psychiatry Invest."},{"key":"10.1016\/j.arr.2024.102257_bib86","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41584-022-00905-1","article-title":"Inflammation and DNA damage: cause, effect or both","volume":"19","author":"Pezone","year":"2023","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.arr.2024.102257_bib87","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200095","article-title":"Levels of soluble interleukin 6 receptor and Asp358Ala are associated with cognitive performance and Alzheimer disease biomarkers","volume":"10","author":"Quillen","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102257_bib88","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1038\/s41467-023-39786-7","article-title":"Challenges in developing geroscience trials","volume":"14","author":"Rolland","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2024.102257_bib89","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12979-023-00352-w","article-title":"Aging and chronic inflammation: highlights from a multidisciplinary workshop","volume":"20","author":"Saavedra","year":"2023","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2024.102257_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111444","article-title":"Connecting vascular aging and frailty in Alzheimer's disease","volume":"195","author":"Sabbatinelli","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102257_bib91","doi-asserted-by":"crossref","first-page":"e860","DOI":"10.1212\/WNL.0000000000201597","article-title":"Diagnostic performance and clinical applicability of blood-based biomarkers in a prospective memory clinic cohort","volume":"100","author":"Sarto","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2024.102257_bib92","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s43587-021-00082-y","article-title":"An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging","volume":"1","author":"Sayed","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2024.102257_bib93","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1212\/WNL.0000000000008081","article-title":"High-precision plasma beta-amyloid 42\/40 predicts current and future brain amyloidosis","volume":"93","author":"Schindler","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2024.102257_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310523","article-title":"Central and peripheral inflammation in mild cognitive impairment in the context of Alzheimer's disease","volume":"24","author":"Schmidt-Morgenroth","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102257_bib95","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41586-023-06436-3","article-title":"Platelet factors attenuate inflammation and rescue cognition in ageing","volume":"620","author":"Schroer","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102257_bib96","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1779","article-title":"Association between serum NPTX2 and cognitive function in patients with vascular dementia","volume":"10","author":"Shao","year":"2020","journal-title":"Brain Behav."},{"key":"10.1016\/j.arr.2024.102257_bib97","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jalz.2018.07.220","article-title":"Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease","volume":"14","author":"Shaw","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib98","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/jnnp-2018-319148","article-title":"Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies","volume":"90","author":"Shen","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2024.102257_bib99","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mam.2018.01.006","article-title":"PDGF\/PDGFR axis in the neural systems","volume":"62","author":"Sil","year":"2018","journal-title":"Mol. Asp. Med"},{"key":"10.1016\/j.arr.2024.102257_bib100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1212\/WNL.0000000000000665","article-title":"Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife","volume":"83","author":"Singh-Manoux","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2024.102257_bib101","unstructured":"Soraci, L., Corsonello, A., Paparazzo, E., Montesanto, A., Piacenza, F., Olivieri, F., Gambuzza, M.E., Savedra, E.V, Marino, S., Lattanzio, F. and Biscetti, L., 2024. Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders. Aging Dis."},{"key":"10.1016\/j.arr.2024.102257_bib102","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13195-019-0477-0","article-title":"Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease","volume":"11","author":"Startin","year":"2019","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2024.102257_bib103","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/imm.12922","article-title":"Inflammation in CNS neurodegenerative diseases","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.arr.2024.102257_bib104","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.3597","article-title":"Association of chronic low-grade inflammation with risk of Alzheimer disease in ApoE4 carriers","volume":"1","author":"Tao","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.arr.2024.102257_bib105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-220971","article-title":"Association of interleukin-6 and interleukin-8 with cognitive decline in an asian memory clinic population","volume":"92","author":"Teoh","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2024.102257_bib106","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(22)00296-4","article-title":"CSF factors in memory function","volume":"21","author":"Teunissen","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib107","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","article-title":"Blood-based biomarkers for Alzheimer's disease: towards clinical implementation","volume":"21","author":"Teunissen","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2024.102257_bib108","doi-asserted-by":"crossref","DOI":"10.1093\/intbio\/zyad012","article-title":"Preliminary study to identify CXCR4 inhibitors as potential therapeutic agents for Alzheimer's and Parkinson's diseases","volume":"15","author":"Tripathi","year":"2023","journal-title":"Integr. Biol. (Camb. )"},{"key":"10.1016\/j.arr.2024.102257_bib109","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1534\/genetics.117.300673","article-title":"A bayesian framework for generalized linear mixed modeling identifies new candidate loci for late-onset Alzheimer's disease","volume":"209","author":"Wang","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.arr.2024.102257_bib110","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1002\/alz.13413","article-title":"Associations of the A\/T\/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy","volume":"19","author":"Wang","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2024.102257_bib111","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann. Intern Med"},{"key":"10.1016\/j.arr.2024.102257_bib112","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2024.102257_bib113","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s11357-022-00540-4","article-title":"Accelerated epigenetic aging and inflammatory\/immunological profile (ipAGE) in patients with chronic kidney disease","volume":"44","author":"Yusipov","year":"2022","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2024.102257_bib114","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13195-023-01254-1","article-title":"Blood and CSF chemokines in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis","volume":"15","author":"Zhou","year":"2023","journal-title":"Alzheimers Res Ther."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724000758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724000758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T21:52:20Z","timestamp":1718488340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724000758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":114,"alternative-id":["S1568163724000758"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102257","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating biomarkers of inflammaging and Alzheimer\u2019s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102257"}}