{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:15:32Z","timestamp":1791303332688,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.arr.2024.102313","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T23:13:20Z","timestamp":1714086800000},"page":"102313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-289X","authenticated-orcid":false,"given":"Nicola","family":"Veronese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Solimando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bolzetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess G.","family":"Fiedorowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fabiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Dragioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia J.","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Barbagallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bellelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102313_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0957154X07076467","article-title":"A brief review of the history of delirium as a mental disorder","volume":"18","author":"Adamis","year":"2007","journal-title":"Hist. Psychiatry"},{"key":"10.1016\/j.arr.2024.102313_bib2","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1056\/NEJMoa2211868","article-title":"Haloperidol for the treatment of delirium in ICU patients","volume":"387","author":"Andersen-Ranberg","year":"2022","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.arr.2024.102313_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnagi.2021.626127","article-title":"Delirium: a marker of vulnerability in older people","volume":"13","author":"Bellelli","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102313_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-016-0649-8","article-title":"Delirium Day\u201d: a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool","volume":"14","author":"Bellelli","year":"2016","journal-title":"BMC Med."},{"key":"10.1016\/j.arr.2024.102313_bib5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00134-021-06490-3","article-title":"Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis","volume":"47","author":"Burry","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.arr.2024.102313_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.accpm.2015.06.012","article-title":"Efficacy and safety of sedation with dexmedetomidine in critical care patients: a meta-analysis of randomized controlled trials","volume":"35","author":"Constantin","year":"2016","journal-title":"Anaesth. Crit. Care Pain\u00a0Med."},{"key":"10.1016\/j.arr.2024.102313_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13054-022-03931-3","article-title":"Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review","volume":"26","author":"la Cour","year":"2022","journal-title":"Crit. Care"},{"key":"10.1016\/j.arr.2024.102313_bib8","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/j.1532-5415.2006.00893.x","article-title":"Preoperative risk assessment for delirium after noncardiac surgery: a systematic review","volume":"54","author":"Dasgupta","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2024.102313_bib9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/ageing\/afz036","article-title":"The Scottish Intercollegiate Guidelines Network: risk reduction and management of delirium","volume":"48","author":"Davis","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2024.102313_bib10","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.arr.2024.102313_bib11","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","article-title":"Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit","volume":"291","author":"Ely","year":"2004","journal-title":"Jama"},{"key":"10.1016\/j.arr.2024.102313_bib12","article-title":"Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement","volume":"378","author":"Gates","year":"2022","journal-title":"bmj"},{"key":"10.1016\/j.arr.2024.102313_bib13","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/ageing\/afaa040","article-title":"The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study","volume":"49","author":"Gibb","year":"2020","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2024.102313_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction\u2014GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.arr.2024.102313_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/ALN.0000000000001660","article-title":"A systematic review and meta-analysis examining the impact of incident postoperative delirium on mortality","volume":"127","author":"Hamilton","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arr.2024.102313_bib16","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jagp.2018.06.007","article-title":"Hospital elder life program: systematic review and meta-analysis of effectiveness","volume":"26","author":"Hshieh","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2024.102313_bib17","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1213\/ANE.0000000000004641","article-title":"American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention","volume":"130","author":"Hughes","year":"2020","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.arr.2024.102313_bib18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199903043400901","article-title":"A multicomponent intervention to prevent delirium in hospitalized older patients","volume":"340","author":"Inouye","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2024.102313_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/B:NERV.0000028080.39602.17","article-title":"The association between delirium and cognitive decline: a review of the empirical literature","volume":"14","author":"Jackson","year":"2004","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.arr.2024.102313_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-3-030-94960-0_26","article-title":"Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis","author":"Joshi","year":"2022","journal-title":"Essent. Rev. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2024.102313_bib21","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1097\/CCM.0000000000003402","article-title":"Incidence and prevalence of delirium subtypes in an adult ICU: a systematic review and meta-analysis","volume":"46","author":"Krewulak","year":"2018","journal-title":"Crit. care Med."},{"key":"10.1016\/j.arr.2024.102313_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archinternmed.2007.4","article-title":"One-year health care costs associated with delirium in the elderly population","volume":"168","author":"Leslie","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.arr.2024.102313_bib23","series-title":"Neurokognitive lidelser, Diagnostic and Statistical Manual of Mental Disorders","author":"Lolk","year":"2013"},{"key":"10.1016\/j.arr.2024.102313_bib24","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1046\/j.1532-5415.2003.51509.x","article-title":"Does delirium increase hospital stay?","volume":"51","author":"McCusker","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.arr.2024.102313_bib25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/gerona\/gly154","article-title":"Delirium, dementia, and in-hospital mortality: the results from the Italian Delirium Day 2016, a national multicenter study","volume":"74","author":"Morandi","year":"2019","journal-title":"J. Gerontol.: Ser. A"},{"key":"10.1016\/j.arr.2024.102313_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000490722","article-title":"A point prevalence study of delirium in Italian nursing homes","volume":"46","author":"Morichi","year":"2018","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.arr.2024.102313_bib27","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1001\/jama.298.22.2644","article-title":"Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial","volume":"298","author":"Pandharipande","year":"2007","journal-title":"Jama"},{"key":"10.1016\/j.arr.2024.102313_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/acps.13066","article-title":"Antipsychotic use and risk of life-threatening medical events: umbrella review of observational studies","volume":"140","author":"Papola","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.arr.2024.102313_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7861\/clinmedicine.6-3-303","article-title":"The prevention, diagnosis and management of delirium in older people: concise guidelines","volume":"6","author":"Potter","year":"2006","journal-title":"Clin. Med."},{"key":"10.1016\/j.arr.2024.102313_bib30","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1001\/jama.2016.2707","article-title":"Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial","volume":"315","author":"Reade","year":"2016","journal-title":"Jama"},{"key":"10.1016\/j.arr.2024.102313_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-7-10","article-title":"Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews","volume":"7","author":"Shea","year":"2007","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.arr.2024.102313_bib32","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/CCM.0000000000003071","article-title":"Sedation intensity in the first 48\u2009h of mechanical ventilation and 180-day mortality: a multinational prospective longitudinal cohort study","volume":"46","author":"Shehabi","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.arr.2024.102313_bib33","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1056\/NEJMoa1904710","article-title":"Early sedation with dexmedetomidine in critically ill patients","volume":"380","author":"Shehabi","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2024.102313_bib34","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1001\/jamasurg.2018.2602","article-title":"Effect of depth of sedation in older patients undergoing hip fracture repair on postoperative delirium: the STRIDE randomized clinical trial","volume":"153","author":"Sieber","year":"2018","journal-title":"JAMA Surg."},{"key":"10.1016\/j.arr.2024.102313_bib35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/psyg.12792","article-title":"Suvorexant with or without ramelteon to prevent delirium: a systematic review and meta-analysis","volume":"22","author":"Tian","year":"2022","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.arr.2024.102313_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac104","article-title":"Comprehensive geriatric assessment in older people: an umbrella review of health outcomes","volume":"51","author":"Veronese","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2024.102313_bib37","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.16780.1","article-title":"Recent advances in preventing and managing postoperative delirium","volume":"8","author":"Vlisides","year":"2019","journal-title":"F1000Research"},{"key":"10.1016\/j.arr.2024.102313_bib38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2024.102313_bib39","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/jamapsychiatry.2018.4365","article-title":"Association of delirium response and safety of pharmacological interventions for the management and prevention of delirium: a network meta-analysis","volume":"76","author":"Wu","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.arr.2024.102313_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2019.101235","article-title":"Melatonergic agents in the prevention of delirium: a network meta-analysis of randomized controlled trials","volume":"50","author":"Yang","year":"2020","journal-title":"Sleep. Med. Rev."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724001314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724001314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T17:16:27Z","timestamp":1715620587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724001314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"alternative-id":["S1568163724001314"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102313","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102313"}}