{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:56:24Z","timestamp":1784598984358,"version":"3.55.0"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["NSFC82003702"],"award-info":[{"award-number":["NSFC82003702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["NSFC31571195"],"award-info":[{"award-number":["NSFC31571195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.arr.2024.102474","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T03:04:42Z","timestamp":1724727882000},"page":"102474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Lactoferrin\/lactoferrin receptor: Neurodegenerative or neuroprotective in Parkinson\u2019s disease?"],"prefix":"10.1016","volume":"101","author":[{"given":"Zhong-Ming","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102474_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102340","article-title":"Understanding role of pesticides in development of Parkinson's disease: insights from Drosophila and rodent models","volume":"98","author":"Afsheen","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0005-2795(72)90283-8","article-title":"Lactoferrin and transferrin: a comparative study","volume":"257","author":"Aisen","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.arr.2024.102474_bib3","article-title":"Advancing the frontier: neuroimaging techniques in the early detection and management of neurodegenerative diseases","volume":"16","author":"Akram","year":"2024","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neulet.2009.01.071","article-title":"Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease","volume":"452","author":"An","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib5","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0022-2836(89)90602-5","article-title":"Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution","volume":"209","author":"Anderson","year":"1989","journal-title":"J. Mol. Biol."},{"issue":"6268","key":"10.1016\/j.arr.2024.102474_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/344784a0","article-title":"Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins","volume":"344","author":"Anderson","year":"1990","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.arr.2024.102474_bib7","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1007\/s00018-005-5368-9","article-title":"Molecular structure, binding properties and dynamics of lactoferrin.","volume":"62","author":"Baker","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2008.05.006","article-title":"A structural framework for understanding the multifunctional character oflactoferrin","volume":"91","author":"Baker","year":"2009","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/CCLM.1999.049","article-title":"Lactoferrin: a multifunctional glycoprotein involvedin the modulation of the inflammatory process.","volume":"37","author":"Baveye","year":"1999","journal-title":"Clin. Chem. Lab. Med."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib10","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1016\/j.foodchem.2013.05.139","article-title":"Physico-chemical properties of different forms of bovine lactoferrin","volume":"141","author":"Bokkhim","year":"2013","journal-title":"Food Chem."},{"issue":"9015","key":"10.1016\/j.arr.2024.102474_bib11","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0140-6736(96)91094-6","article-title":"Pumping iron in Parkinson\u2019s disease","volume":"347","author":"Bonn","year":"1996","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"StagingofbrainpathologyrelatedtosporadicParkinson'sdisease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102474_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.taap.2017.01.019","article-title":"Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K\/Akt and ERK signaling pathways","volume":"319","author":"Cao","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.arr.2024.102474_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109461","article-title":"Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6\/STAT3 axis","volume":"65","author":"Cutone","year":"2020","journal-title":"Cell Signal."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"6 Pt 1","key":"10.1016\/j.arr.2024.102474_bib16","first-page":"G930","article-title":"Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn","volume":"257","author":"Davidson","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2024.102474_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.med.47.1.219","article-title":"Nitric oxide synthase: role as a transmitter\/mediator in the brain and endocrine system","volume":"47","author":"Dawson","year":"1996","journal-title":"Annu. Rev. Med."},{"issue":"9","key":"10.1016\/j.arr.2024.102474_bib18","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3168\/jds.S0022-0302(93)77594-3","article-title":"Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli","volume":"76","author":"Dionysius","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.arr.2024.102474_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1204149","article-title":"Lactoferrin: neuroprotection against Parkinson's disease and secondary molecule for potential treatment","volume":"15","author":"Eker","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102474_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120355","article-title":"Lactoferrin, a multi-functional glycoprotein: active therapeutic, drug nanocarrier & targeting ligand","volume":"263","author":"Elzoghby","year":"2020","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.siny.2013.02.001","article-title":"Lactoferrin: antimicrobial activity and therapeutic potential","volume":"18","author":"Embleton","year":"2013","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib22","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1111\/j.1471-4159.1993.tb03527.x","article-title":"Distribution of 125I-ferrotransferrin binding sites in the mesencephalon of control subjects and patients with Parkinson's disease","volume":"60","author":"Faucheux","year":"1993","journal-title":"J. Neurochem."},{"issue":"21","key":"10.1016\/j.arr.2024.102474_bib23","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1073\/pnas.92.21.9603","article-title":"Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease","volume":"92","author":"Faucheux","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1-2","key":"10.1016\/j.arr.2024.102474_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-8993(95)00629-5","article-title":"Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys","volume":"691","author":"Faucheux","year":"1995","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0006-8993(96)01412-6","article-title":"The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease","volume":"749","author":"Faucheux","year":"1997","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1471-4159.2002.01118.x","article-title":"Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease","volume":"83","author":"Faucheux","year":"2002","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.arr.2024.102474_bib27","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1046\/j.1471-4159.2003.01923.x","article-title":"Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease","volume":"86","author":"Faucheux","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2024.102474_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-4757-9068-9_36","article-title":"Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment","volume":"443","author":"Fillebeen","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib29","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1046\/j.1471-4159.1999.0732491.x","article-title":"Tumor necrosis factor-alpha increases lactoferrin transcytosis through the blood-brain barrier","volume":"73","author":"Fillebeen","year":"1999","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0169-328X(99)00221-1","article-title":"Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment","volume":"72","author":"Fillebeen","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"11","key":"10.1016\/j.arr.2024.102474_bib31","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1074\/jbc.274.11.7011","article-title":"Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier","volume":"274","author":"Fillebeen","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1-2","key":"10.1016\/j.arr.2024.102474_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0169-328X(01)00216-9","article-title":"Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment","volume":"96","author":"Fillebeen","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.170.2.415","article-title":"Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity","volume":"170","author":"Furmanski","year":"1989","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib34","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbagen.2011.06.018","article-title":"Lactoferrin a multiple bioactive protein: an overview","volume":"1820","author":"Garc\u00eda-Montoya","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jcp.1041530306","article-title":"Lactoferrin binding sites and nuclear localization in K562(S) cells","volume":"153","author":"Garr\u00e9","year":"1992","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1046\/j.1471-4159.1994.63030793.x","article-title":"Altered brain metabolism of iron as acauseofneurodegenerativediseases?","volume":"63","author":"Gerlach","year":"1994","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib37","first-page":"L933","article-title":"Respiratory epithelial cells demonstratelactoferrinreceptorsthat increase after metal exposure","volume":"276","author":"Ghio","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2024.102474_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102834","article-title":"Decreased salivary lactoferrin levels are specific to Alzheimer's disease","volume":"57","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2020","journal-title":"eBioMedicine"},{"issue":"13","key":"10.1016\/j.arr.2024.102474_bib39","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1021\/ja01498a029","article-title":"The isolation of a red protein from Milk2","volume":"82","author":"Groves","year":"1960","journal-title":"J. Am. Chem. Soc."},{"issue":"6516","key":"10.1016\/j.arr.2024.102474_bib40","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/373721a0","article-title":"Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA","volume":"373","author":"He","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102474_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/978-3-211-45295-0_39","article-title":"How to judge animal models of Parkinson's disease in terms of neuroprotection","volume":"70","author":"Hirsch","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"issue":"Suppl 3","key":"10.1016\/j.arr.2024.102474_bib42","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1016\/S1353-8020(09)70816-8","article-title":"Iron transport in Parkinson's disease","volume":"15","author":"Hirsch","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.arr.2024.102474_bib43","first-page":"69","article-title":"Commentary: is Alzheimer\u2019s disease iron overload of the brain?","volume":"3","author":"Hodgkins","year":"1997","journal-title":"Alzheimer\u2019s\u00a0Res."},{"issue":"10","key":"10.1016\/j.arr.2024.102474_bib44","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.4049\/jimmunol.179.10.6504","article-title":"Requirement for both JAK-mediated PI3K signaling and ACT1\/TRAF6\/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells","volume":"179","author":"Huang","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib45","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.4238\/2011.December.21.1","article-title":"Two splice variants of the bovine lactoferrin gene identified in Staphylococcus aureus isolated from mastitis in dairy cattle","volume":"10","author":"Huang","year":"2011","journal-title":"Genet. Mol. Res."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib46","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10534-022-00453-x","article-title":"Lactoferrin: from the structure to the functional orchestration of iron homeostasis","volume":"36","author":"Ianiro","year":"2023","journal-title":"Biometals"},{"key":"10.1016\/j.arr.2024.102474_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141378","article-title":"Role of LRP1 and ERK and cAMP signaling pathways in lactoferrin-induced lipolysis in mature rat adipocytes","volume":"10","author":"Ikoma-Seki","year":"2015","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib48","first-page":"232","article-title":"Lactoferrin, lactoferrin receptors and iron metabolism","volume":"47","author":"Iyer","year":"1993","journal-title":"Eur. J. Clin. Nutr."},{"issue":"Pt 6 Pt 2","key":"10.1016\/j.arr.2024.102474_bib49","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1107\/S0907444998004417","article-title":"Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change","volume":"54","author":"Jameson","year":"1998","journal-title":"Acta Crystallogr. D\u00a0Biol. Crystallogr."},{"issue":"11","key":"10.1016\/j.arr.2024.102474_bib50","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1007\/s12035-021-02516-5","article-title":"Toxic feedback loop involvingiron, reactive oxygen species, \u03b1-synuclein and neuromelanin inParkinson'sdiseaseand intervention with turmeric","volume":"58","author":"Jansen van Rensburg","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10534-018-0080-z","article-title":"Cloning and characterization of the human lactoferrin receptor gene promoter","volume":"31","author":"Jiang","year":"2018","journal-title":"Biometals"},{"issue":"11","key":"10.1016\/j.arr.2024.102474_bib52","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1002\/jcp.22650","article-title":"Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells","volume":"226","author":"Jiang","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1292\/jvms.70.313","article-title":"Trans-endothelial and trans-epithelial transfer of lactoferrin into the brain through BBB and BCSFB in adult rats","volume":"70","author":"Kamemori","year":"2008","journal-title":"J. Vet. Med. Sci."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib54","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1572-0241.2003.07458.x","article-title":"Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation","volume":"98","author":"Kane","year":"2003","journal-title":"Am. J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib55","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/ijms18040870","article-title":"Studying Lactoferrin N-Glycosylation","volume":"18","author":"Karav","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5 Pt 1","key":"10.1016\/j.arr.2024.102474_bib56","first-page":"G841","article-title":"Isolation and function of a receptor for human lactoferrin in human fetal intestinal brush-border membranes","volume":"261","author":"Kawakami","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.arr.2024.102474_bib57","first-page":"1574","article-title":"Lactotransferrin immunocytochemistry in Alzheimer and normal human brain","volume":"142","author":"Kawamata","year":"1993","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2007.07.009","article-title":"Brain iron metabolism: neurobiology and neurochemistry","volume":"83","author":"Ke","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib59","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(03)00353-3","article-title":"Iron misregulation in the brain: a primary cause of neurodegenerative disorders","volume":"2","author":"Ke","year":"2003","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.129459","article-title":"Bayesian inference for parameter estimation in lactoferrin-mediated iron transport across blood-brain barrier","volume":"1864","author":"Khan","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/biology10010024","article-title":"Pretreatment with human lactoferrin had a positive effect on the dynamics of mouse nigrostriatal system recovery after acute MPTP exposure","volume":"10","author":"Kopaeva","year":"2021","journal-title":"Biology"},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib62","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10517-019-04572-3","article-title":"Transport of human lactoferrin into mouse brain: administration routes and distribution","volume":"167","author":"Kopaeva","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib63","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbagen.2011.06.002","article-title":"Molecular evolution of the transferrin family and associated receptors","volume":"1820","author":"Lambert","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbpb.2005.07.007","article-title":"Evolution of the transferrin family: conservation of residues associated with iron and anion binding","volume":"142","author":"Lambert","year":"2005","journal-title":"Comp. Biochem. Physiol. B\u00a0Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib65","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/toxins2010054","article-title":"Reciprocal interactions between lactoferrin and bacterial endotoxins and their role in the regulation of the immune response","volume":"2","author":"Latorre","year":"2010","journal-title":"Toxins"},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib66","first-page":"118","article-title":"Lactoferrin - a glycoprotein of great therapeutic potentials","volume":"20","author":"Lauterbach","year":"2016","journal-title":"Dev. Period. Med."},{"key":"10.1016\/j.arr.2024.102474_bib67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biopha.2017.10.121","article-title":"In vitro and in vivo toxicity assessment of alginate\/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs)","volume":"97","author":"Leng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib68","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0006-8993(94)90202-X","article-title":"The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis","volume":"650","author":"Leveugle","year":"1994","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib69","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s004010050468","article-title":"Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases","volume":"91","author":"Leveugle","year":"1996","journal-title":"Acta Neuropathol."},{"issue":"7","key":"10.1016\/j.arr.2024.102474_bib70","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3390\/cells10071810","article-title":"A review on lactoferrin and central nervous system diseases","volume":"10","author":"Li","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jnc.14857","article-title":"Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice","volume":"152","author":"Liu","year":"2020","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/BJ20070393","article-title":"Lactoferrinreceptormediates apo- but not holo-lactoferrininternalization via clathrin-mediated endocytosis in trophoblasts","volume":"411","author":"Lopez","year":"2008","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1432-1033.1989.tb14578.x","article-title":"Expression of human lactotransferrin receptors in phytohemagglutinin-stimulated human peripheral blood lymphocytes. Isolation of the receptors by antiligand-affinity chromatography.","volume":"179","author":"Mazurier","year":"1989","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib74","first-page":"19","article-title":"MPTP mouse models of Parkinson's disease: an update","volume":"1","author":"Meredith","year":"2011","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.arr.2024.102474_bib75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neulet.2018.01.052","article-title":"Feeding the developing brain: juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits","volume":"677","author":"Mika","year":"2018","journal-title":"Neurosci. Lett."},{"issue":"Pt 2","key":"10.1016\/j.arr.2024.102474_bib76","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/bj3080391","article-title":"Effect of intracellular iron depletion by picolinic acid on expression of the lactoferrin receptor in the human colon carcinoma cell subclone HT29-18-C1","volume":"308","author":"Mikogami","year":"1995","journal-title":"Biochem. J."},{"issue":"12","key":"10.1016\/j.arr.2024.102474_bib77","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jnutbio.2010.09.015","article-title":"Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes","volume":"22","author":"Moreno-Navarrete","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"5","key":"10.1016\/j.arr.2024.102474_bib78","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2990.1994.tb00997.x","article-title":"Transferrin receptors in the Parkinsonian midbrain","volume":"20","author":"Morris","year":"1994","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00702-018-1903-3","article-title":"Human tyrosine hydroxylase in Parkinson's disease and in related disorders","volume":"126","author":"Nagatsu","year":"2019","journal-title":"J. Neural Transm."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jtos.2012.12.002","article-title":"Dry eye disease and microbial keratitis: is there a connection?","volume":"11","author":"Narayanan","year":"2013","journal-title":"Ocul. Surf."},{"issue":"21","key":"10.1016\/j.arr.2024.102474_bib81","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1212\/01.wnl.0000262033.01945.9a","article-title":"Individual dopaminergic neurons show raised iron levels in Parkinson disease","volume":"68","author":"Oakley","year":"2007","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib82","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.3390\/pharmaceutics15041056","article-title":"Time to kill and time to heal: the multifaceted role of lactoferrin and lactoferricin in host defense","volume":"15","author":"Ohradanova-Repic","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.arr.2024.102474_bib83","first-page":"460","article-title":"The central theme of Parkinson\u2019s disease: \u03b1-synuclein","volume":"42","author":"Ozansoy","year":"2012","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.arr.2024.102474_bib84","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.3390\/molecules29112614","article-title":"Zeolite and neurodegenerative diseases","volume":"29","author":"Panaiotov","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2024.102474_bib85","article-title":"Prevalence of radicular neuropathic pain in idiopathic Parkinson's disease: a systematic review and meta-analysis","volume":"25","author":"Pereira","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2024.102474_bib86","first-page":"1","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"12","key":"10.1016\/j.arr.2024.102474_bib87","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"issue":"14","key":"10.1016\/j.arr.2024.102474_bib88","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/JB.181.14.4417-4419.1999","article-title":"Structuralcharacterizationof thelactoferrinreceptorfromNeisseriameningitidis","volume":"181","author":"Prinz","year":"1999","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib89","first-page":"455","article-title":"Brain iron and neurological disorders","volume":"110","author":"Qian","year":"1997","journal-title":"Chin. Med. J."},{"issue":"5","key":"10.1016\/j.arr.2024.102474_bib90","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/brv.12521","article-title":"Brain iron transport","volume":"94","author":"Qian","year":"2019","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib91","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/med.21631","article-title":"Hepcidin and its therapeutic potential in neurodegenerative disorders","volume":"40","author":"Qian","year":"2020","journal-title":"Med. Res. Rev."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib92","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1471-4914(00)01910-9","article-title":"Brain iron transport and neurodegeneration","volume":"7","author":"Qian","year":"2001","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib93","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0167-4889(95)00098-X","article-title":"Mechanisms of iron uptake by mammalian cells","volume":"1269","author":"Qian","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib94","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-0173(98)00012-5","article-title":"Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders","volume":"27","author":"Qian","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6107(97)00009-6","article-title":"Iron crosses the endosomal membrane by a carrier-mediated process","volume":"67","author":"Qian","year":"1997","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.arr.2024.102474_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101961","article-title":"Ferroportin1 in the brain","volume":"88","author":"Qian","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib97","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/molecules26010205","article-title":"Lactoferrin: a glycoprotein involved in immunomodulation, anticancer, and antimicrobial processes","volume":"26","author":"Rasc\u00f3n-Cruz","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib98","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/pharmaceutics15030865","article-title":"Biomedical applications of lactoferrin on the ocular surface","volume":"15","author":"Regueiro","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib99","first-page":"295","article-title":"Pathogenesis of Parkinson's disease","volume":"5","author":"Riederer","year":"1992","journal-title":"Curr. Opin. Neurol. Neurosurg."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1471-4159.1989.tb09150.x","article-title":"Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains","volume":"52","author":"Riederer","year":"1989","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib101","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1124\/mol.113.087965","article-title":"The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis","volume":"84","author":"Rousseau","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"1-3","key":"10.1016\/j.arr.2024.102474_bib102","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbaexp.2005.11.005","article-title":"Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue","volume":"1732","author":"Sch\u00e4ffler","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"1-2","key":"10.1016\/j.arr.2024.102474_bib103","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-4328(01)00309-6","article-title":"Behavioral phenotyping of the MPTP mouse model of Parkinson's disease","volume":"125","author":"Sedelis","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib104","first-page":"153","article-title":"Lactoferrin-like immunoreactivity in distinct neuronal populations in the mouse central nervous system","volume":"75","author":"Shimaoka","year":"2021","journal-title":"Acta Med. Okayama"},{"issue":"6","key":"10.1016\/j.arr.2024.102474_bib105","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1073\/pnas.94.6.2198","article-title":"Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines","volume":"94","author":"Siebert","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib106","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1139\/o01-228","article-title":"Characterization of mammalian receptors for lactoferrin","volume":"80","author":"Suzuki","year":"2002","journal-title":"Biochem. Cell. Biol."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib107","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1023\/B:BIOM.0000027709.42733.e4","article-title":"Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse","volume":"17","author":"Suzuki","year":"2004","journal-title":"Biometals"},{"issue":"51","key":"10.1016\/j.arr.2024.102474_bib108","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1021\/bi0155899","article-title":"Molecular cloning and functional expression of a human intestinal lactoferrin receptor","volume":"40","author":"Suzuki","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2024.102474_bib109","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-005-5371-1","article-title":"Mammalian lactoferrin receptors: structure and function","volume":"62","author":"Suzuki","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"22","key":"10.1016\/j.arr.2024.102474_bib110","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-005-5371-1","article-title":"Mammalian lactoferrin receptors: structure and function","volume":"62","author":"Suzuki","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"10","key":"10.1016\/j.arr.2024.102474_bib111","first-page":"783","article-title":"Binding characteristics and distribution of lactoferrin receptors in the gut and choroid plexus in newborn calves","volume":"44","author":"Talukder","year":"2006","journal-title":"Indian J. Exp. Biol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib112","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1001\/jamaneurol.2013.6233","article-title":"Parkinson disease subtypes","volume":"71","author":"Thenganatt","year":"2014","journal-title":"JAMA Neurol."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib113","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/jnnp-2019-322042","article-title":"Brain iron deposition is linked with cognitive severity in Parkinson's disease","volume":"91","author":"Thomas","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"26","key":"10.1016\/j.arr.2024.102474_bib114","doi-asserted-by":"crossref","first-page":"23456","DOI":"10.1074\/jbc.M103162200","article-title":"Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall","volume":"276","author":"Tsuji","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.arr.2024.102474_bib115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/o2012-016","article-title":"Lactoferrin, a bird's eye view","volume":"90","author":"Vogel","year":"2012","journal-title":"Biochem. Cell. Biol."},{"issue":"3-4","key":"10.1016\/j.arr.2024.102474_bib116","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10534-006-9062-7","article-title":"A structural comparison of human serum transferrin and human lactoferrin","volume":"20","author":"Wally","year":"2007","journal-title":"Biometals"},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib117","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/10408398.2017.1381583","article-title":"Lactoferrin: structure, function, denaturation and digestion","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.arr.2024.102474_bib118","article-title":"The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.arr.2024.102474_bib119","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.rbmo.2010.10.003","article-title":"Characterization oflactoferrinreceptoron human spermatozoa","volume":"22","author":"Wang","year":"2011","journal-title":"Reprod. Biomed. Online"},{"issue":"36","key":"10.1016\/j.arr.2024.102474_bib120","doi-asserted-by":"crossref","first-page":"26172","DOI":"10.1016\/S0021-9258(18)35732-6","article-title":"Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance","volume":"267","author":"Willnow","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.arr.2024.102474_bib121","first-page":"184","article-title":"Brain iron correlates with cognitive change in Parkinson disease","volume":"16","author":"Wood","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2024.102474_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101090","article-title":"Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice","volume":"21","author":"Xu","year":"2019","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.arr.2024.102474_bib123","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/glia.24259","article-title":"Astrocyte-specific loss of lactoferrin influences neuronal structure and function by interfering with cholesterol synthesis","volume":"70","author":"Xu","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.arr.2024.102474_bib124","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.2c00679","article-title":"Neuroprotective effects of lactoferrin in Alzheimer's and Parkinson's diseases: a narrative review","author":"Yong","year":"2023","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2024.102474_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mds.870080102","article-title":"The possible role of iron in the etiopathology of Parkinson's disease","volume":"8","author":"Youdim","year":"1993","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2024.102474_bib126","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1749-6632.1994.tb21790.x","article-title":"Oxygen free radicals and neurodegeneration in Parkinson's disease: a role for nitric oxide","volume":"738","author":"Youdim","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"8","key":"10.1016\/j.arr.2024.102474_bib127","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.7150\/thno.95953","article-title":"Stem cell-derived extracellular vesicles in the therapeutic intervention of Alzheimer's Disease, Parkinson's Disease, and stroke","volume":"14","author":"Zhou","year":"2024","journal-title":"Theranostics"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724002927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724002927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T02:54:14Z","timestamp":1730516054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724002927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":127,"alternative-id":["S1568163724002927"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102474","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactoferrin\/lactoferrin receptor: Neurodegenerative or neuroprotective in Parkinson\u2019s disease?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102474"}}