{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:48:03Z","timestamp":1768520883266,"version":"3.49.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.arr.2024.102510","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T16:38:34Z","timestamp":1727195914000},"page":"102510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-9542","authenticated-orcid":false,"given":"Ludmila","family":"Kucikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Reinecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Madden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Tappin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Eleni","family":"Dounavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-3986","authenticated-orcid":false,"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"May","key":"10.1016\/j.arr.2024.102510_bib1","first-page":"1","article-title":"Lipid metabolism crosstalk in the brain: Glia and neurons","volume":"13","author":"Barber","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2024.102510_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: Anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn3475","article-title":"Power failure: Why small sample size undermines the reliability of neuroscience","volume":"14","author":"Button","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-36820-3","article-title":"Polygenic impact of common genetic risk loci for Alzheimer\u2019s disease on cerebral blood flow in young individuals","volume":"9","author":"Chandler","year":"2019","journal-title":"Sci. Rep."},{"issue":"19 PART 2","key":"10.1016\/j.arr.2024.102510_bib5","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1212\/01.wnl.0000304038.37421.cc","article-title":"APOE \u03b54 allele predicts faster cognitive decline in mild Alzheimer disease","volume":"70","author":"Cosentino","year":"2008","journal-title":"Neurology"},{"issue":"April","key":"10.1016\/j.arr.2024.102510_bib6","article-title":"Medial temporal lobe atrophy and posterior atrophy scales normative values","volume":"24","author":"Cotta Ramusino","year":"2019","journal-title":"NeuroImage: Clin."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-59327-2","article-title":"Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer\u2019s Disease","volume":"10","author":"Dalboni da Rocha","year":"2020","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.arr.2024.102510_bib8","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \u201cdefault network\u201d in normal aging","volume":"18","author":"Damoiseaux","year":"2008","journal-title":"Cereb. Cortex"},{"issue":"24","key":"10.1016\/j.arr.2024.102510_bib9","doi-asserted-by":"crossref","first-page":"8254","DOI":"10.1523\/JNEUROSCI.0305-12.2012","article-title":"Gender modulates the APOE \u03b54 effect in healthy older adults: Convergent evidence from functional brain connectivity and spinal fluid tau levels","volume":"32","author":"Damoiseaux","year":"2012","journal-title":"J. Neurosci."},{"issue":"OCT","key":"10.1016\/j.arr.2024.102510_bib10","first-page":"1","article-title":"Two Alzheimer\u2019s disease risk genes increase entorhinal cortex volume in young adults","volume":"8","author":"DiBattista","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib11","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/nbm.2912","article-title":"MRI of carriers of the apolipoprotein E e4 allele-evidence for structural differences in normal-appearing brain tissue in e4+ relative to e4- young adults.","volume":"26","author":"Dowell","year":"2013","journal-title":"NMR Biomed."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/nbm.3502","article-title":"Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers","volume":"29","author":"Dowell","year":"2016","journal-title":"NMR Biomed."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/nbm.3502","article-title":"Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers","volume":"29","author":"Dowell","year":"2016","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.arr.2024.102510_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.612","article-title":"Disrupted neural activity patterns to novelty and effort in young adult APOE-e4 carriers performing a subsequent memory task","volume":"7","author":"Evans","year":"2017","journal-title":"Brain Behav."},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0198312","article-title":"Using event-related fMRI to examine sustained attention processes and effects of APOE \u03b54 in young adults","volume":"13","author":"Evans","year":"2018","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-022-00566-4","article-title":"APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer\u2019s disease pathology and brain diseases","volume":"17","author":"Fern\u00e1ndez-Calle","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"January","key":"10.1016\/j.arr.2024.102510_bib17","first-page":"1","article-title":"Potential Pitfalls of Using Fractional Anisotropy, Axial Diffusivity, and Radial Diffusivity as Biomarkers of Cerebral White Matter Microstructure","volume":"15","author":"Figley","year":"2022","journal-title":"Front. Neurosci."},{"issue":"17","key":"10.1016\/j.arr.2024.102510_bib18","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-\u03b54 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib19","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archneur.62.6.953","article-title":"Sex, apolipoprotein E \u03b54 status, and hippocampal volume in mild cognitive impairment","volume":"62","author":"Fleisher","year":"2005","journal-title":"Arch. Neurol."},{"issue":"July","key":"10.1016\/j.arr.2024.102510_bib20","article-title":"Inclusion of Neuropsychological Scores in Atrophy Models Improves Diagnostic Classification of Alzheimer\u2019s Disease and Mild Cognitive Impairment","volume":"2015","author":"Goryawala","year":"2015","journal-title":"Comput. Intell. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropsychologia.2013.12.020","article-title":"A combined effect of two Alzheimer\u2019s risk genes on medial temporal activity during executive attention in young adults","volume":"56","author":"Green","year":"2014","journal-title":"Neuropsychologia"},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1037\/a0031891","article-title":"Age and apolipoprotein E \u03b54 effects on neural correlates of odor memory","volume":"127","author":"Green","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.arr.2024.102510_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.arr.2017.03.004","article-title":"Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer\u2019s disease","volume":"36","author":"Habib","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2024.102510_bib24","article-title":"The apolipoprotein e antagonistic pleiotropy hypothesis: Review and recommendations","volume":"2011","author":"Han","year":"2011","journal-title":"Int. J. Alzheimer\u2019S. Dis."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2010.09.001","article-title":"Apolipoprotein E: From lipid transport to neurobiology","volume":"50","author":"Hauser","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.arr.2024.102510_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2018.08.026","article-title":"Increased posterior default mode network activity and structural connectivity in young adult APOE-\u03b54 carriers: a multimodal imaging investigation","volume":"73","author":"Hodgetts","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/braincomms\/fcad234","article-title":"Genetic risks of Alzheimer\u2019s by APOE and MAPT on cortical morphology in young healthy adults","volume":"5","author":"Huang","year":"2023","journal-title":"Brain Commun."},{"key":"10.1016\/j.arr.2024.102510_bib28","first-page":"450","article-title":"Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography","volume":"11","author":"Hughes","year":"2019","journal-title":"Alzheimer\u2019S. Dement.: Diagn., Assess. Dis. Monit."},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1037\/a0026769","article-title":"APOE \u03b54 and cognitive function in early life: a meta-analysis","volume":"26","author":"Ihle","year":"2012","journal-title":"Neuropsychology"},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/jamaneurol.2014.4821","article-title":"Age, sex, and APOE \u03f54 effects on memory, brain structure, and \u03b2-Amyloid across the adult life Span","volume":"72","author":"Jack","year":"2015","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuropsychologia.2012.11.018","article-title":"Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for neuropsychological investigations","volume":"51","author":"Jones","year":"2013","journal-title":"Neuropsychologia"},{"issue":"July)","key":"10.1016\/j.arr.2024.102510_bib32","article-title":"Apolipoprotein E Genotype e2: Neuroprotection and Its Limits","volume":"14","author":"Kim","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"11","key":"10.1016\/j.arr.2024.102510_bib33","doi-asserted-by":"crossref","first-page":"833","DOI":"10.14348\/molcells.2014.0224","article-title":"Apolipoprotein E in synaptic plasticity and alzheimer\u2019s disease: Potential cellular and molecular mechanisms","volume":"37","author":"Kim","year":"2014","journal-title":"Mol. Cells"},{"issue":"21","key":"10.1016\/j.arr.2024.102510_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells12212512","article-title":"Detrimental Effects of ApoE \u03b54 on Blood\u2013Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer\u2019s Disease","volume":"12","author":"Kirchner","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.arr.2024.102510_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.36011","article-title":"Oscillatory hyperactivity and hyperconnectivity in young APOE-\u03b54 carriers and hypoconnectivity in alzheimer\u2019s disease","volume":"8","author":"Koelewijn","year":"2019","journal-title":"ELife"},{"issue":"July","key":"10.1016\/j.arr.2024.102510_bib36","first-page":"1","article-title":"APOE2 is associated with spatial navigational strategies and increased gray matter in the hippocampus","volume":"10","author":"Konishi","year":"2016","journal-title":"Front. Hum. Neurosci."},{"issue":"May","key":"10.1016\/j.arr.2024.102510_bib37","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neubiorev.2021.07.024","article-title":"Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer\u2019s disease","volume":"129","author":"Kucikova","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"10","key":"10.1016\/j.arr.2024.102510_bib38","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1007\/s00415-023-11809-9","article-title":"Genetic risk factors of Alzheimer\u2019s Disease disrupt resting-state functional connectivity in cognitively intact young individuals","volume":"270","author":"Kucikova","year":"2023","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib39","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3233\/JAD-160854","article-title":"Conscientiousness is Negatively Associated with Grey Matter Volume in Young APOE \u03f54-Carriers","volume":"56","author":"Kunz","year":"2017","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"847","key":"10.1016\/j.arr.2024.102510_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1749-6632.2000.tb06365.x","article-title":"Lipoproteins in the central nervous system","volume":"903","author":"Ladu","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"21","key":"10.1016\/j.arr.2024.102510_bib41","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/j.cub.2020.08.042","article-title":"Genetic Alzheimer\u2019s Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields","volume":"30","author":"Lee","year":"2020","journal-title":"Curr. Biol."},{"issue":"11","key":"10.1016\/j.arr.2024.102510_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0206803","article-title":"Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0003-066X.41.1.3","article-title":"A Conception of Adult Development","volume":"41","author":"Levinson","year":"1986","journal-title":"Am. Psychol."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib44","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/ejn.15915","article-title":"Resting-state brain signal complexity discriminates young healthy APOE e4 carriers from non-e4 carriers","volume":"57","author":"Li","year":"2023","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2024.102510_bib45","article-title":"Tract-specific differences in white matter microstructure between young adult APOE \u03b54 carriers and non-carriers: A replication and extension study","volume":"2","author":"Lissaman","year":"2022","journal-title":"Neuroimage: Rep."},{"key":"10.1016\/j.arr.2024.102510_bib46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2015.12.023","article-title":"The effect of increased genetic risk for Alzheimer\u2019s disease on hippocampal and amygdala volume","volume":"40","author":"Lupton","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2024.102510_bib47","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.arr.2016.10.001","article-title":"Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes","volume":"35","author":"Mak","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"September","key":"10.1016\/j.arr.2024.102510_bib48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","article-title":"Accurate automatic estimation of total intracranial volume: A nuisance variable with less nuisance","volume":"104","author":"Malone","year":"2015","journal-title":"NeuroImage"},{"issue":"7902","key":"10.1016\/j.arr.2024.102510_bib49","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-022-04492-9","article-title":"Reproducible brain-wide association studies require thousands of individuals","volume":"603","author":"Marek","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102510_bib50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroimage.2013.11.042","article-title":"Differential effects of the ApoE4 genotype on brain structure and function","volume":"89","author":"Matura","year":"2014","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3233\/JAD-150990","article-title":"Age-Related Effects of the Apolipoprotein e Gene on Brain Function","volume":"52","author":"Matura","year":"2016","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"June","key":"10.1016\/j.arr.2024.102510_bib52","article-title":"Functional co-activation of the default mode network in APOE \u03b54-carriers: A replication study","volume":"240","author":"Mentink","year":"2021","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.arr.2024.102510_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.arr.2024.102510_bib54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neurobiolaging.2020.06.014","article-title":"Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults","volume":"94","author":"Mole","year":"2020","journal-title":"Neurobiol. Aging"},{"issue":"sue 7806","key":"10.1016\/j.arr.2024.102510_bib55","article-title":"APOE4 leads to early blood-brain barrier dysfunction predicting human cognitive decline","volume":"Vol. 581","author":"Montagne","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102510_bib56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cortex.2018.03.025","article-title":"APOE genotype and cognition in healthy individuals at risk of Alzheimer\u2019s disease: A review","volume":"104","author":"O\u2019Donoghue","year":"2018","journal-title":"Cortex"},{"issue":"Issue January","key":"10.1016\/j.arr.2024.102510_bib57","article-title":"Apolipoprotein E Genotype Moderation of the Association Between Physical Activity and Brain Health. A Systematic Review and Meta-Analysis","volume":"Vol. 13","author":"Pearce","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib58","first-page":"2212","article-title":"APOE \u03b54 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD. Alzheimer\u2019s","volume":"19","author":"Polsinelli","year":"2023","journal-title":"Dementia"},{"issue":"October","key":"10.1016\/j.arr.2024.102510_bib59","first-page":"1","article-title":"The Relationship of APOE \u03b54, Race, and Sex on the Age of Onset and Risk of Dementia","volume":"12","author":"Powell","year":"2021","journal-title":"Front. Neurol."},{"issue":"7","key":"10.1016\/j.arr.2024.102510_bib60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.braindev.2009.08.006","article-title":"Voxel-based analysis of white matter during adolescence and young adulthood","volume":"32","author":"Qiu","year":"2010","journal-title":"Brain Dev."},{"issue":"2","key":"10.1016\/j.arr.2024.102510_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-022-03123-4","article-title":"Hippocampus and its involvement in Alzheimer\u2019s disease: a review","volume":"12","author":"Rao","year":"2022","journal-title":"3 Biotech"},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer\u2019s disease: pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jamapsychiatry.2016.3356","article-title":"Effect size estimation in neuroimaging","volume":"74","author":"Reddan","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib64","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3109\/09540261.2013.869195","article-title":"The PREVENT research programme-A novel research programme to identify and manage midlife risk for dementia: The conceptual framework","volume":"25","author":"Ritchie","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.arr.2024.102510_bib65","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuroimage.2012.10.010","article-title":"APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures","volume":"65","author":"Rusted","year":"2013","journal-title":"NeuroImage"},{"issue":"8","key":"10.1016\/j.arr.2024.102510_bib66","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1212\/WNL.58.8.1182","article-title":"Association between the APOE genotype and psychopathologic symptoms in Alzheimer\u2019s disease","volume":"58","author":"Scarmeas","year":"2002","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib67","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s00429-017-1377-3","article-title":"Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults","volume":"222","author":"Shen","year":"2017","journal-title":"Brain Struct. Funct."},{"issue":"2","key":"10.1016\/j.arr.2024.102510_bib68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12264-016-0011-3","article-title":"An Overview of Genome-Wide Association Studies in Alzheimer\u2019s Disease","volume":"32","author":"Shen","year":"2016","journal-title":"Neurosci. Bull."},{"issue":"November","key":"10.1016\/j.arr.2024.102510_bib69","first-page":"1","article-title":"APOE-\u03b54 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults","volume":"5","author":"Shine","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/03014460600594513","article-title":"APOE distribution in world populations with new data from India and the UK","volume":"33","author":"Singh","year":"2006","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.arr.2024.102510_bib71","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2015.11.006","article-title":"Apolipoprotein E \u03b54 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults","volume":"299","author":"Stening","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2024.102510_bib72","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbr.2017.03.013","article-title":"Specific patterns of whole-brain structural covariance of the anterior and posterior hippocampus in young APOE \u03b54 carriers","volume":"326","author":"Stening","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib73","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s11682-022-00724-8","article-title":"Demographic reporting across a decade of neuroimaging: a systematic review","volume":"16","author":"Sterling","year":"2022","journal-title":"Brain Imaging Behav."},{"issue":"5","key":"10.1016\/j.arr.2024.102510_bib74","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-avidity binding to \u03b2-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"52","key":"10.1016\/j.arr.2024.102510_bib75","first-page":"1","article-title":"APOE polymorphism affects brain default mode network in healthy young adults: A STROBE article","volume":"94","author":"Su","year":"2015","journal-title":"Med. (U. S. )"},{"issue":"52","key":"10.1016\/j.arr.2024.102510_bib76","article-title":"APOE polymorphism affects brain default mode network in healthy young adults: A STROBE article","volume":"94","author":"Su","year":"2015","journal-title":"Med. (U. S. )"},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib77","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s11682-016-9556-z","article-title":"Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE \u03b54","volume":"11","author":"Su","year":"2017","journal-title":"Brain Imaging Behav."},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib78","first-page":"648","article-title":"Reduced cerebrovascular reactivity in young adults carrying the APOE \u03b54 allele. Alzheimer\u2019s","volume":"11","author":"Suri","year":"2015","journal-title":"Dementia"},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib79","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/cercor\/bhaa251","article-title":"Sex-Dependent Effects of the APOE \u03f54 Allele on Behavioral Traits and White Matter Structures in Young Adults","volume":"31","author":"Takeuchi","year":"2021","journal-title":"Cereb. Cortex"},{"issue":"7","key":"10.1016\/j.arr.2024.102510_bib80","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00429-021-02334-4","article-title":"The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students","volume":"226","author":"Tsuchida","year":"2021","journal-title":"Brain Struct. Funct."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib81","first-page":"1","article-title":"APOE \u03b54 and resting-state functional connectivity in racially\/ethnically diverse older adults","volume":"12","author":"Turney","year":"2020","journal-title":"Alzheimer\u2019S. Dement.: Diagn., Assess. Dis. Monit."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib82","first-page":"1","article-title":"APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia","volume":"15","author":"Vipin","year":"2023","journal-title":"Alzheimer\u2019S. Res. Ther."},{"issue":"January","key":"10.1016\/j.arr.2024.102510_bib83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neubiorev.2018.08.009","article-title":"Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans","volume":"94","author":"Weissberger","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"December 2019","key":"10.1016\/j.arr.2024.102510_bib84","article-title":"APOE-amyloid interaction: Therapeutic targets","volume":"138","author":"Wisniewski","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.arr.2024.102510_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49028-z","article-title":"Co-aggregation with Apolipoprotein E modulates the function of Amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"15","author":"Xia","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.arr.2024.102510_bib86","first-page":"673","article-title":"Late-Onset Alzheimer\u2019s Disease Polygenic Risk Profile Score Predicts Hippocampal Function","volume":"2","author":"Xiao","year":"2017","journal-title":"Biol. Psychiatry.: Cogn. Neurosci. Neuroimaging"},{"issue":"7","key":"10.1016\/j.arr.2024.102510_bib87","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1002\/hbm.22398","article-title":"The APOE \u025b4 allele affects complexity and functional connectivity of resting brain activity in healthy adults","volume":"35","author":"Yang","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"10","key":"10.1016\/j.arr.2024.102510_bib88","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.arr.2024.102510_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0118338","article-title":"Apolipoprotein \u03b54 is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults","volume":"10","author":"Yokoyama","year":"2015","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.arr.2024.102510_bib90","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.arr.2024.102510_bib91","doi-asserted-by":"crossref","unstructured":"Zhang, N., Liu, H., Qin, W., Liu, B., Jiang, T., & Yu, C. (2017). APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults. September 2016, 4797\u20134805. https:\/\/doi.org\/10.1093\/cercor\/bhw276.","DOI":"10.1093\/cercor\/bhw276"},{"issue":"June","key":"10.1016\/j.arr.2024.102510_bib92","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejrad.2017.07.006","article-title":"Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1\/2 and APOE \u03b54","volume":"95","author":"Zheng","year":"2017","journal-title":"Eur. J. Radiol."},{"issue":"4","key":"10.1016\/j.arr.2024.102510_bib93","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1007\/s12035-017-0540-4","article-title":"Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP\/Presenilin-1\/2 and APOE\u03b54","volume":"55","author":"Zheng","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.arr.2024.102510_bib94","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s12035-021-02292-2","article-title":"Different posterior hippocampus and default mode network modulation in young APOE \u03b54 carriers: a functional connectome-informed phenotype longitudinal study","volume":"58","author":"Zheng","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"July 2018","key":"10.1016\/j.arr.2024.102510_bib95","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neuroimage.2018.10.046","article-title":"Apolipoprotein \u03b54 is associated with better cognitive control allocation in healthy young adults","volume":"185","author":"Zink","year":"2019","journal-title":"NeuroImage"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724003283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724003283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T02:56:49Z","timestamp":1730516209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724003283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":95,"alternative-id":["S1568163724003283"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102510","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102510"}}