{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:54:47Z","timestamp":1793858087251,"version":"4.6.1"},"reference-count":254,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007470","name":"Shaqra University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/10\/45"],"award-info":[{"award-number":["RGP2\/10\/45"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019286","name":"Ajman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.arr.2024.102575","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T01:58:18Z","timestamp":1730944698000},"page":"102575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways"],"prefix":"10.1016","volume":"102","author":[{"given":"Mohammed","family":"Alrouji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyad","family":"Shahwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Imtaiyaz","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Shamsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102575_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00466","article-title":"Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration","volume":"12","author":"Abdalkader","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","article-title":"The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death","volume":"84","author":"Ai","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2024.102575_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/jnnp-2020-323271","article-title":"Clinical staging in amyotrophic lateral sclerosis: analysis of Edaravone Study 19","volume":"92","author":"Al-Chalabi","year":"2021","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"key":"10.1016\/j.arr.2024.102575_bib4","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/gerona\/glt079","article-title":"Basic biology of skeletal aging: role of stress response pathways","volume":"68","author":"Almeida","year":"2013","journal-title":"J. Gerontol. Ser. A: Biomed. Sci. Med. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib5","doi-asserted-by":"crossref","unstructured":"Amarya, S., Singh, K., Sabharwal, M., 2018. Ageing process and physiological changes, Gerontology. IntechOpen.","DOI":"10.5772\/intechopen.76249"},{"key":"10.1016\/j.arr.2024.102575_bib6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.neuron.2007.10.038","article-title":"Disruption of large-scale brain systems in advanced aging","volume":"56","author":"Andrews-Hanna","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2024.102575_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jnc.13024","article-title":"Lipid peroxidation is essential for \u03b1-synuclein-induced cell death","volume":"133","author":"Angelova","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2024.102575_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fnagi.2018.00065","article-title":"The aging of iron man","volume":"10","author":"Ashraf","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib9","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1038\/s41598-018-37431-8","article-title":"Pattern of altered plasma elemental phosphorus, calcium, zinc, and iron in Alzheimer\u2019s disease","volume":"9","author":"Ashraf","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2024.102575_bib10","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2024.102575_bib11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"cell"},{"key":"10.1016\/j.arr.2024.102575_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/antiox12040901","article-title":"Oxidative Stress, Inflammation and Colorectal Cancer: An Overview","volume":"12","author":"Bardel\u010d\u00edkov\u00e1","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102575_bib13","unstructured":"Barks, A.K., 2020. The effect of developmental iron deficiency on gene expression, TET proteins, and DNA hydroxymethylation in the rodent brain. University of Minnesota.."},{"key":"10.1016\/j.arr.2024.102575_bib14","article-title":"Oxidative stress and lipid peroxidation products in cancer progression and therapy","volume":"2012","author":"Barrera","year":"2012","journal-title":"ISRN Oncol."},{"key":"10.1016\/j.arr.2024.102575_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.706650","article-title":"Lipid metabolism regulates oxidative stress and ferroptosis in RAS-driven cancers: a perspective on cancer progression and therapy","volume":"8","author":"Bartolacci","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.arr.2024.102575_bib16","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1039\/D3SC02350H","article-title":"A natural polyphenol activates and enhances GPX4 to mitigate amyloid-\u03b2 induced ferroptosis in Alzheimer's disease","volume":"14","author":"Baruah","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cmet.2016.05.011","article-title":"Metformin as a tool to target aging","volume":"23","author":"Barzilai","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2024.102575_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1060028016673072","article-title":"Use of vitamin E and C supplements for the prevention of cognitive decline","volume":"51","author":"Basambombo","year":"2017","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.arr.2024.102575_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.brain.2023.100063","article-title":"Iron level changes in the brain with neurodegenerative disease","volume":"4","author":"Bazala","year":"2023","journal-title":"Brain Multiphys."},{"key":"10.1016\/j.arr.2024.102575_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-6-8","article-title":"Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinson's brain","volume":"6","author":"Bellinger","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2024.102575_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000213789","article-title":"Synaptic structural dynamics and aging","volume":"42","author":"Bertoni-Freddari","year":"1996","journal-title":"Gerontology"},{"key":"10.1016\/j.arr.2024.102575_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117080","article-title":"The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain","volume":"220","author":"Birkl","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.arr.2024.102575_bib23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3390\/metabo10110450","article-title":"Energy metabolism decline in the aging brain\u2014pathogenesis of neurodegenerative disorders","volume":"10","author":"B\u0142aszczyk","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.arr.2024.102575_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/BST20220434","article-title":"The interactions of amyloid \u03b2 aggregates with phospholipid membranes and the implications for neurodegeneration","volume":"51","author":"Budvytyte","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.arr.2024.102575_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrn1809","article-title":"Neural plasticity in the ageing brain","volume":"7","author":"Burke","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/ijms20030609","article-title":"\u03b1-Lipoic acid reduces iron-induced toxicity and oxidative stress in a model of iron overload","volume":"20","author":"Camiolo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib27","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell. Mol. life Sci."},{"key":"10.1016\/j.arr.2024.102575_bib28","article-title":"Inhibition of acyl-CoA synthetase long-chain family member 4 facilitates neurological recovery after stroke by regulation ferroptosis","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s12951-023-02129-1","article-title":"Bone-targeting exosome nanoparticles activate Keap1 \/ Nrf2 \/ GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.arr.2024.102575_bib30","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2024.102575_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed","volume":"11","author":"Cherry","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2024.102575_bib32","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2024.102575_bib33","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.arr.2024.102575_bib34","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1093\/cvr\/cvab184","article-title":"SGLT2 inhibitors and the cardiac Na+\/H+ exchanger-1: the plot thickens","volume":"117","author":"Chung","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.arr.2024.102575_bib35","series-title":"Selenium: Its Molecular Biology and Role in Human Health","first-page":"547","article-title":"Mouse Models for Glutathione Peroxidase 4 (GPx4)","author":"Conrad","year":"2012"},{"key":"10.1016\/j.arr.2024.102575_bib36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system xc\u2212: cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.arr.2024.102575_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.soc.2019.08.009","article-title":"Diffuse large B-cell lymphoma and high-grade B-cell lymphoma: genetic classification and its implications for prognosis and treatment","volume":"29","author":"Crombie","year":"2020","journal-title":"Surg. Oncol. Clin."},{"key":"10.1016\/j.arr.2024.102575_bib38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12979-019-0164-9","article-title":"Immunosenescence and human vaccine immune responses","volume":"16","author":"Crooke","year":"2019","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2024.102575_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.901565","article-title":"Post-translational modification of GPX4 is a promising target for treating ferroptosis-related diseases","volume":"9","author":"Cui","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.arr.2024.102575_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bcp.2018.10.030","article-title":"Brain ageing and neurodegenerative disease: the role of cellular waste management","volume":"158","author":"Daniele","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib41","article-title":"Oxytosis\/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)","author":"Dar","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib42","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/sj.emboj.7601735","article-title":"Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin","volume":"26","author":"De Domenico","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2024.102575_bib43","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s10571-023-01411-y","article-title":"Nrf2 and ferroptosis: a new research direction for ischemic stroke","volume":"43","author":"Deng","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4933-5-11","article-title":"Immunity, ageing and cancer","volume":"5","author":"Derhovanessian","year":"2008","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2024.102575_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101716","article-title":"Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer\u2019s disease from a ferroptosis perspective","volume":"184","author":"Derry","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib46","article-title":"Limitations of serum ferritin in diagnosing iron deficiency in inflammatory conditions","volume":"2018","author":"Dignass","year":"2018","journal-title":"Int. J. Chronic Dis."},{"key":"10.1016\/j.arr.2024.102575_bib47","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1111\/febs.14379","article-title":"The role of Nrf2 signaling in counteracting neurodegenerative diseases","volume":"285","author":"Dinkova-Kostova","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.arr.2024.102575_bib48","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Lamprecht MRet al. Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib49","first-page":"1","article-title":"The cell biology of ferroptosis","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2024.102575_bib50","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/iub.1616","article-title":"Iron and ferroptosis: a still ill-defined liaison","volume":"69","author":"Doll","year":"2017","journal-title":"IUBMB life"},{"key":"10.1016\/j.arr.2024.102575_bib52","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1167\/iovs.06-0568","article-title":"Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture","volume":"47","author":"Dunaief","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/ejh.13345","article-title":"The role of iron repletion in adult iron deficiency anemia and other diseases","volume":"104","author":"Elstrott","year":"2020","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.arr.2024.102575_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006203","article-title":"Unsolved mysteries: how does lipid peroxidation cause ferroptosis?","volume":"16","author":"Feng","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2024.102575_bib56","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41401-020-0439-x","article-title":"ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma","volume":"42","author":"Feng","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.arr.2024.102575_bib57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.arr.2024.102575_bib58","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.3390\/ijms231710018","article-title":"Iron deposition in brain: does aging matter?","volume":"23","author":"Ficiar\u00e0","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib59","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMra1004967","article-title":"Iron overload in human disease","volume":"366","author":"Fleming","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2024.102575_bib60","series-title":"Selenium","first-page":"177","article-title":"Selenium and Neurodevelopment","author":"Fradejas-Villar","year":"2018"},{"key":"10.1016\/j.arr.2024.102575_bib61","article-title":"The ubiquity of iron","author":"Frey","year":"2012","journal-title":"ACS Publ."},{"key":"10.1016\/j.arr.2024.102575_bib62","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2024.102575_bib63","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.3390\/molecules28073157","article-title":"Targeting mTOR for anti-aging and anti-cancer therapy","volume":"28","author":"Fu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2024.102575_bib64","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","article-title":"Programmed cell death in animal development and disease","volume":"147","author":"Fuchs","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib65","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.canlet.2013.12.028","article-title":"New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinoma","volume":"346","author":"Galmiche","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.arr.2024.102575_bib66","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2024.102575_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4246255","article-title":"Emerging Pathological Engagement of Ferroptosis in Gut Diseases","volume":"2021","author":"Gao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102575_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(24)00035-4","article-title":"National prevalence of vision impairment and blindness and associated risk factors in adults aged 40 years and older with known or undiagnosed diabetes: results from the SMART-India cross-sectional study","author":"Gurudas","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.arr.2024.102575_bib69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/ars.2017.7299","article-title":"Epigenetics and immunometabolism in diabetes and aging","volume":"29","author":"Guzik","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2024.102575_bib70","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neulet.2009.12.035","article-title":"Selenium attenuates A\u03b2 production and A\u03b2-induced neuronal death","volume":"469","author":"Gwon","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2024.102575_bib71","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1021\/acs.biochem.0c00030","article-title":"Ferroptosis suppressor protein 1 (FSP1) and coenzyme Q10 cooperatively suppress ferroptosis","volume":"59","author":"Hadian","year":"2020","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2024.102575_bib72","first-page":"1","article-title":"The therapeutic potential of targeting regulated non-apoptotic cell death","author":"Hadian","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2024.102575_bib73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1167\/iovs.10-6113","article-title":"Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice","volume":"52","author":"Hadziahmetovic","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib74","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archopht.121.8.1099","article-title":"Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane","volume":"121","author":"Hahn","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.arr.2024.102575_bib75","unstructured":"Harraan, D., 1955. Aging: a theory based on free radical and radiation chemistry.."},{"key":"10.1016\/j.arr.2024.102575_bib76","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"Harrison","year":"1996","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Bioenerg."},{"key":"10.1016\/j.arr.2024.102575_bib77","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of Mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.arr.2024.102575_bib79","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2024.102575_bib80","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3390\/cells11132040","article-title":"Ferroptosis and its role in chronic diseases","volume":"11","author":"Hu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.arr.2024.102575_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.827900","article-title":"A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic interventions","volume":"14","author":"Iakovou","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib82","series-title":"Methods and Protocols","first-page":"291","article-title":"Determination and Detection of Reactive Oxygen Species (ROS), Lipid Peroxidation, and Electrolyte Leakage in Plants","author":"Jambunathan","year":"2010"},{"key":"10.1016\/j.arr.2024.102575_bib83","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56580","article-title":"Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans","volume":"9","author":"Jenkins","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.arr.2024.102575_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1005182","article-title":"Insight into the potential role of ferroptosis in neurodegenerative diseases","volume":"16","author":"Ji","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib85","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1073\/pnas.98.4.1930","article-title":"The effects of aging on gene expression in the hypothalamus and cortex of mice","volume":"98","author":"Jiang","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib86","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/med.21939","article-title":"Novel druggable mechanism of Parkinson's disease: potential therapeutics and underlying pathogenesis based on ferroptosis","volume":"43","author":"Jiang","year":"2023","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib87","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102575_bib88","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11243-012-9583-6","article-title":"Redox active metal-induced oxidative stress in biological systems","volume":"37","author":"Jomova","year":"2012","journal-title":"Transit. Met. Chem."},{"key":"10.1016\/j.arr.2024.102575_bib89","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa7161","article-title":"Personalized genomic analyses for cancer mutation discovery and interpretation","volume":"7","author":"Jones","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.arr.2024.102575_bib90","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ana.25356","article-title":"N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","volume":"84","author":"Karuppagounder","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2024.102575_bib91","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"Kaushik","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2024.102575_bib92","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.molcel.2017.02.024","article-title":"An inflammatory perspective on necroptosis","volume":"65","author":"Kearney","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2024.102575_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101924","article-title":"Nature's toolbox against tau aggregation: an updated review of current research","author":"Khan","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib94","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/acel.12601","article-title":"Molecular and physiological manifestations and measurement of aging in humans","volume":"16","author":"Khan","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102575_bib95","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.3390\/pharmaceutics14122657","article-title":"Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches","volume":"14","author":"Khan","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.arr.2024.102575_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102113","article-title":"Recent advancement in therapeutic strategies for Alzheimer\u2019s disease: Insights from clinical trials","author":"Khan","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib97","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mib.2015.11.003","article-title":"Infection in an aging population","volume":"29","author":"Kline","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.arr.2024.102575_bib98","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.arr.2024.102575_bib99","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2024.102575_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib101","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1242\/jcs.01097","article-title":"Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells","volume":"117","author":"Kurz","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2024.102575_bib102","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib103","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.3390\/ijms21197152","article-title":"Neuroprotective effect of antioxidants in the brain","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib104","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0005-2728(98)00120-0","article-title":"Role of mitochondria in oxidative stress and ageing","volume":"1366","author":"Lenaz","year":"1998","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Bioenerg."},{"key":"10.1016\/j.arr.2024.102575_bib105","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.18632\/aging.100864","article-title":"Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer\u2019s disease related cognitive functioning","volume":"7","author":"Levine","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2024.102575_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01120","article-title":"Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib107","article-title":"System Xc\u2212\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib108","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2024.102575_bib109","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-019-0165-8","article-title":"Age related human T cell subset evolution and senescence","volume":"16","author":"Li","year":"2019","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2024.102575_bib110","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cophys.2020.10.004","article-title":"Chemokines in cardiac fibrosis","volume":"19","author":"Li","year":"2021","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.arr.2024.102575_bib111","article-title":"Mechanisms of Ferritinophagy and Ferroptosis in Diseases","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2024.102575_bib113","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12964-023-01267-1","article-title":"Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.arr.2024.102575_bib114","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.arr.2024.102575_bib115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41422-019-0258-0","article-title":"A new checkpoint against ferroptosis","volume":"30","author":"Liang","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.arr.2024.102575_bib116","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.arr.2024.102575_bib117","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101610R","article-title":"Activation of osteoblast ferroptosis via the METTL3\/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss","volume":"36","author":"Lin","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2024.102575_bib118","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10637-021-01070-0","article-title":"System Xc\u2212: a key regulatory target of ferroptosis in cancer","volume":"39","author":"Liu","year":"2021","journal-title":"Investig. N. Drugs"},{"key":"10.1016\/j.arr.2024.102575_bib119","article-title":"The critical role of ferritinophagy in human disease","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib120","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1021\/acsnano.8b05860","article-title":"Ferrous-supply-regeneration nanoengineering for cancer-cell-specific ferroptosis in combination with imaging-guided photodynamic therapy","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2024.102575_bib121","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1248\/bpb.b15-00048","article-title":"The 5-lipoxygenase inhibitor zileuton confers neuroprotection against glutamate oxidative damage by inhibiting ferroptosis","volume":"38","author":"Liu","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.arr.2024.102575_bib122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003329","article-title":"Evolution of the aging brain transcriptome and synaptic regulation","volume":"3","author":"Loerch","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.arr.2024.102575_bib123","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2024.102575_bib124","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","article-title":"The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells","volume":"356","author":"Louandre","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.arr.2024.102575_bib126","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1038\/s41467-023-41626-7","article-title":"Structural insights into FSP1 catalysis and ferroptosis inhibition","volume":"14","author":"Lv","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2024.102575_bib127","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10565-022-09778-2","article-title":"Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases","volume":"39","author":"Lv","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.arr.2024.102575_bib128","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s12551-023-01126-w","article-title":"The critical role of mitochondrial lipid peroxidation in ferroptosis: insights from recent studies","volume":"15","author":"Lyamzaev","year":"2023","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib129","first-page":"21","article-title":"The biology of ageing: a primer","volume":"1","author":"de Magalh\u00e3es","year":"2011","journal-title":"Introd. Gerontol."},{"key":"10.1016\/j.arr.2024.102575_bib130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13059-023-02888-y","article-title":"Ageing as a software design flaw","volume":"24","author":"de Magalh\u00e3es","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.arr.2024.102575_bib131","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.chembiol.2020.10.010","article-title":"Using the oxytosis\/ferroptosis pathway to understand and treat age-associated neurodegenerative diseases","volume":"27","author":"Maher","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib132","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2024.102575_bib133","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/antiox12030651","article-title":"Aging hallmarks and the role of oxidative stress","volume":"12","author":"Maldonado","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102575_bib134","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1750-1326-4-24","article-title":"Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle","volume":"4","author":"Malkus","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2024.102575_bib135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00702-020-02271-2","article-title":"Iron and inflammation: in vivo and post-mortem studies in Parkinson\u2019s disease","volume":"128","author":"Martin-Bastida","year":"2021","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2024.102575_bib136","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41420-021-00553-6","article-title":"Implication of ferroptosis in aging","volume":"7","author":"Mazhar","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.arr.2024.102575_bib137","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ceb.2017.02.004","article-title":"The emerging role of retromer in neuroprotection","volume":"47","author":"McMillan","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.arr.2024.102575_bib138","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2024.102575_bib139","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.3390\/nu5125161","article-title":"Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research","volume":"5","author":"Michels","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2024.102575_bib140","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0047-6374(01)00269-X","article-title":"Replicative mosaicism might explain the seeming contradictions in the telomere theory of aging","volume":"122","author":"Mikhelson","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102575_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2024.102575_bib142","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1196\/annals.1297.069","article-title":"Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila","volume":"1019","author":"Miwa","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib143","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4161\/cc.28433","article-title":"Genetics and epigenetics of aging and longevity","volume":"13","author":"Moskalev","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2024.102575_bib144","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2024.102575_bib145","doi-asserted-by":"crossref","unstructured":"Moura, J., 2023. Editorial: Immune aging and its consequences. Frontiers in Endocrinology 14.","DOI":"10.3389\/fendo.2023.1250141"},{"key":"10.1016\/j.arr.2024.102575_bib146","doi-asserted-by":"crossref","first-page":"B202","DOI":"10.1093\/gerona\/57.5.B202","article-title":"Fertility and life span: late children enhance female longevity","volume":"57","author":"M\u00fcller","year":"2002","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib147","doi-asserted-by":"crossref","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a risk factor for disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib148","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12935-021-02366-0","article-title":"Induction and application of ferroptosis in cancer therapy","volume":"22","author":"Nie","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.arr.2024.102575_bib149","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1111\/bph.14567","article-title":"Treating Alzheimer's disease by targeting iron","volume":"176","author":"Nikseresht","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib150","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3390\/antiox12061250","article-title":"Oxidative stress-induced cellular senescence: is labile iron the connecting link?","volume":"12","author":"Nousis","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102575_bib151","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nm.3651","article-title":"Stem cell aging: mechanisms, regulators and therapeutic opportunities","volume":"20","author":"Oh","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2024.102575_bib152","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuint.2011.11.009","article-title":"Reactive oxygen species and ischemic cerebrovascular disease","volume":"60","author":"Olmez","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2024.102575_bib153","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2024.102575_bib154","doi-asserted-by":"crossref","unstructured":"Pamp, O., 2015. Aging and its Consequences.","DOI":"10.1007\/978-3-658-08615-2_2"},{"key":"10.1016\/j.arr.2024.102575_bib155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102575_bib156","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11938-018-0174-2","article-title":"Management of anemia in patients with inflammatory bowel disease (IBD)","volume":"16","author":"Patel","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.arr.2024.102575_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583019","article-title":"Targeting inflammation and immunosenescence to improve vaccine responses in the elderly","volume":"11","author":"Pereira","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2024.102575_bib158","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6236309","article-title":"Ageing-associated oxidative stress and inflammation are alleviated by products from grapes","volume":"2016","author":"Petersen","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102575_bib159","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1053\/j.gastro.2015.06.045","article-title":"Genetics, genetic testing, and management of hemochromatosis: 15 years since hepcidin","volume":"149","author":"Pietrangelo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arr.2024.102575_bib160","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.freeradbiomed.2018.06.016","article-title":"Adaptive homeostasis and the free radical theory of ageing","volume":"124","author":"Pomatto","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2024.102575_bib161","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2009.11.2\/cqiu","article-title":"Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention","volume":"11","author":"Qiu","year":"2009","journal-title":"Dialog-. Clin. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib162","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000371708","article-title":"Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review","volume":"61","author":"Quan","year":"2015","journal-title":"Gerontology"},{"key":"10.1016\/j.arr.2024.102575_bib163","series-title":"Ferroptosis in Health and Disease","first-page":"99","article-title":"Gpx4 and Ferroptosis","author":"Ran","year":"2019"},{"key":"10.1016\/j.arr.2024.102575_bib164","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/gerona\/62.9.932","article-title":"Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis","volume":"62","author":"Ran","year":"2007","journal-title":"J. Gerontol.: Ser. A"},{"key":"10.1016\/j.arr.2024.102575_bib165","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-24152-2","article-title":"Ferroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve","volume":"12","author":"Rayatpour","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2024.102575_bib166","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib167","first-page":"193","article-title":"Molecular aspects of bone resorption in \u03b2-thalassemia major","volume":"17","author":"Saki","year":"2015","journal-title":"Cell J."},{"key":"10.1016\/j.arr.2024.102575_bib168","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3390\/antiox12040782","article-title":"The Key Role of Mitochondrial Function in Health and Disease","volume":"12","author":"San-Mill\u00e1n","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102575_bib169","doi-asserted-by":"crossref","first-page":"37423","DOI":"10.1074\/jbc.M506439200","article-title":"Redox imbalance in cystine\/glutamate transporter-deficient mice","volume":"280","author":"Sato","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2024.102575_bib170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mad.2017.11.012","article-title":"Ferrosenescence: the iron age of neurodegeneration?","volume":"174","author":"Sfera","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102575_bib171","doi-asserted-by":"crossref","first-page":"165","DOI":"10.14348\/molcells.2023.0005","article-title":"Anti-ferroptotic effects of Nrf2: beyond the antioxidant response","volume":"46","author":"Shakya","year":"2023","journal-title":"Mol. Cells"},{"key":"10.1016\/j.arr.2024.102575_bib172","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9074206","article-title":"Positive and negative regulation of ferroptosis and its role in maintaining metabolic and redox homeostasis","volume":"2021","author":"Sharma","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102575_bib173","article-title":"Ferroptosis: biochemistry and biology in cancers","volume":"11","author":"Shi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.arr.2024.102575_bib174","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.stem.2013.01.001","article-title":"Mechanisms that regulate stem cell aging and life span","volume":"12","author":"Signer","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2024.102575_bib175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2010.10.002","article-title":"Impact of cellular senescence signature on ageing research","volume":"10","author":"Sikora","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2024.102575_bib176","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/BST20200672","article-title":"Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms","volume":"49","author":"Sim\u00e3o","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.arr.2024.102575_bib177","series-title":"Molecular Basis and Emerging Strategies for Anti-aging Interventions","first-page":"161","article-title":"Autophagy Induction: A Promising Antiaging Strategy","author":"Singh","year":"2018"},{"key":"10.1016\/j.arr.2024.102575_bib178","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2021.62.9.843","article-title":"Temozolomide drives ferroptosis via a DMT1-dependent pathway in glioblastoma cells","volume":"62","author":"Song","year":"2021","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.arr.2024.102575_bib179","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00267","article-title":"Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases","volume":"14","author":"Song","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib180","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/bph.14881","article-title":"CuII (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease","volume":"177","author":"Southon","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib181","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib182","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib183","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.hfc.2011.08.011","article-title":"Aging-associated cardiovascular changes and their relationship to heart failure","volume":"8","author":"Strait","year":"2012","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.arr.2024.102575_bib184","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102575_bib185","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1043344","article-title":"Ferritinophagy, a form of autophagic ferroptosis: new insights into cancer treatment","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib186","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1089\/dna.2020.5730","article-title":"Lipid peroxidation, GSH depletion, and SLC7A11 inhibition are common causes of EMT and ferroptosis in A549 cells, but different in specific mechanisms","volume":"40","author":"Sun","year":"2021","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.arr.2024.102575_bib187","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The mitochondrial basis of aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2024.102575_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110108","article-title":"The emerging role of ferroptosis in inflammation","volume":"127","author":"Sun","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2024.102575_bib189","first-page":"9","article-title":"Antioxidant and oxidative stress: a mutual interplay in age-related diseases","author":"Tan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib190","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib191","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.3390\/molecules23123305","article-title":"Overview on the effects of N-acetylcysteine in neurodegenerative diseases","volume":"23","author":"Tardiolo","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2024.102575_bib192","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","article-title":"Apoptosis in the pathogenesis and treatment of disease","volume":"267","author":"Thompson","year":"1995","journal-title":"science"},{"key":"10.1016\/j.arr.2024.102575_bib193","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.627837","article-title":"Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress","volume":"12","author":"Tirichen","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.arr.2024.102575_bib194","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10863-007-9090-1","article-title":"Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate\u2014DIDS","volume":"39","author":"Tomaskova","year":"2007","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.arr.2024.102575_bib195","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1111\/cas.14496","article-title":"Ferroptosis at the crossroads of infection, aging and cancer","volume":"111","author":"Toyokuni","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.arr.2024.102575_bib196","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2007.01905.x","article-title":"Mitochondrial dysfunction as a cause of ageing","volume":"263","author":"Trifunovic","year":"2008","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.arr.2024.102575_bib197","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.3390\/ijms24043380","article-title":"Aggregation of disordered proteins associated with neurodegeneration","volume":"24","author":"Tsoi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib198","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2024.102575_bib199","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1741-7015-11-94","article-title":"Age-related autoimmunity","volume":"11","author":"Vadasz","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.arr.2024.102575_bib200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox- and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.arr.2024.102575_bib201","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/ars.2021.0136","article-title":"Tetrahydrobiopterin in cell function and death mechanisms","volume":"37","author":"Vasquez-Vivar","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.arr.2024.102575_bib202","series-title":"Ferroptosis: Mechanism and Diseases","first-page":"25","article-title":"IronIronsHomeostasis and Metabolism: Two Sides of a Coin","author":"Venkataramani","year":"2021"},{"key":"10.1016\/j.arr.2024.102575_bib203","series-title":"Plant Epigenetics","first-page":"281","article-title":"Dynamic DNA Methylation Patterns in Stress Response","author":"Viggiano","year":"2017"},{"key":"10.1016\/j.arr.2024.102575_bib204","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/15216540601178067","article-title":"Theories of ageing","volume":"59","author":"Vi\u00f1a","year":"2007","journal-title":"IUBMB life"},{"key":"10.1016\/j.arr.2024.102575_bib205","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.hoc.2017.11.006","article-title":"Clinical classification, screening and diagnosis for thalassemia","volume":"32","author":"Viprakasit","year":"2018","journal-title":"Hematol. \/Oncol. Clin."},{"key":"10.1016\/j.arr.2024.102575_bib206","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"Von Zglinicki","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib207","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri3561","article-title":"Concepts of tissue injury and cell death in inflammation: a historical perspective","volume":"14","author":"Wallach","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2024.102575_bib208","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.arr.2024.102575_bib209","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(21)02796-3","article-title":"Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020\u201321","volume":"399","author":"Wang","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2024.102575_bib210","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20101825","article-title":"Regulation of cellular iron metabolism","volume":"434","author":"Wang","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2024.102575_bib211","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13020-023-00838-1","article-title":"A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis","volume":"18","author":"Wang","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.arr.2024.102575_bib212","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10495-023-01902-9","article-title":"Ferroptosis: Underlying mechanisms and involvement in neurodegenerative diseases","volume":"29","author":"Wang","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.arr.2024.102575_bib213","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.bbamcr.2012.03.004","article-title":"Ferroportin-mediated iron transport: expression and regulation","volume":"1823","author":"Ward","year":"2012","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"10.1016\/j.arr.2024.102575_bib214","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10534-011-9415-8","article-title":"The many faces of the octahedral ferritin protein","volume":"24","author":"Watt","year":"2011","journal-title":"BioMetals"},{"key":"10.1016\/j.arr.2024.102575_bib215","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2021.02.010","article-title":"Aging lens epithelium is susceptible to ferroptosis","volume":"167","author":"Wei","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2024.102575_bib216","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.bmcl.2011.09.047","article-title":"Development of small-molecule probes that selectively kill cells induced to express mutant RAS","volume":"22","author":"We\u00efwer","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.arr.2024.102575_bib217","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0034-5687(01)00313-9","article-title":"Ageing and the free radical theory","volume":"128","author":"Wickens","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.arr.2024.102575_bib218","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1471-4159.2011.07536.x","article-title":"Pathogenic implications of iron accumulation in multiple sclerosis","volume":"120","author":"Williams","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2024.102575_bib219","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41598-017-18935-1","article-title":"Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells","volume":"8","author":"Wu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2024.102575_bib220","article-title":"Global research trends of ferroptosis: a rapidly evolving field with enormous potential","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib221","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1007\/s12035-023-03245-7","article-title":"The role of iron metabolism, lipid metabolism, and redox homeostasis in Alzheimer\u2019s disease: from the perspective of ferroptosis","volume":"60","author":"Wu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib222","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-020-01157-x","article-title":"The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.arr.2024.102575_bib223","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/JXX.0000000000000579","article-title":"Genomics of aging: decreased immune defenses","volume":"33","author":"Wysocki","year":"2021","journal-title":"J. Am. Assoc. Nurse Pract."},{"key":"10.1016\/j.arr.2024.102575_bib224","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/hmg\/11.9.1137","article-title":"Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin","volume":"11","author":"Wyttenbach","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.arr.2024.102575_bib225","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2024.102575_bib226","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.arr.2024.102575_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2024.102575_bib228","first-page":"780","article-title":"Transplanted senescent cells induce an osteoarthritis-like condition in mice","volume":"72","author":"Xu","year":"2017","journal-title":"J. Gerontol. Ser. A: Biomed. Sci. Med. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib229","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2024.102575_bib230","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature05859","article-title":"RAS\u2013RAF\u2013MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.arr.2024.102575_bib231","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/antiox12091739","article-title":"NRF2, a Superstar of Ferroptosis","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2024.102575_bib232","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.697621","article-title":"Functional aging in male C57BL\/6J mice across the life-span: a systematic behavioral analysis of motor, emotional, and memory function to define an aging phenotype","volume":"13","author":"Yanai","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2024.102575_bib233","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102799","article-title":"Metabolic intervention nanoparticles for triple-negative breast cancer therapy via overcoming FSP1-mediated ferroptosis resistance","volume":"11","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.arr.2024.102575_bib234","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13024-023-00634-3","article-title":"Axonal energy metabolism, and the effects in aging and neurodegenerative diseases","volume":"18","author":"Yang","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2024.102575_bib235","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib236","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.arr.2024.102575_bib237","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102575_bib238","first-page":"537","article-title":"Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats","volume":"43","author":"Yefimova","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib239","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/acschembio.2c00028","article-title":"Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1)","volume":"17","author":"Yoshioka","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2024.102575_bib240","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mad.2015.02.002","article-title":"Reconfiguration of DNA methylation in aging","volume":"151","author":"Zampieri","year":"2015","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2024.102575_bib241","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10571-024-01459-4","article-title":"Iron deposition in Parkinson\u2019s disease: a mini-review","volume":"44","author":"Zeng","year":"2024","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.arr.2024.102575_bib242","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41416-022-01800-y","article-title":"Targeting NQO1\/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth","volume":"127","author":"Zhan","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.arr.2024.102575_bib243","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.arr.2024.102575_bib244","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11427-020-1795-4","article-title":"Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses","volume":"64","author":"Zhang","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.arr.2024.102575_bib245","article-title":"Mechanisms and regulations of ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2024.102575_bib246","doi-asserted-by":"crossref","first-page":"9395","DOI":"10.3390\/ijms23169395","article-title":"Iron metabolism and ferroptosis in physiological and pathological pregnancy","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2024.102575_bib247","article-title":"Iron dyshomeostasis and ferroptosis in Alzheimer\u2019s disease: molecular mechanisms of cell death and novel therapeutic drugs and targets for AD","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2024.102575_bib248","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2017.11.001","article-title":"\u03b1-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice","volume":"14","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2024.102575_bib249","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.3390\/foods11152189","article-title":"Polyphenols as plant-based nutraceuticals: health effects, encapsulation, nano-delivery, and application","volume":"11","author":"Zhang","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.arr.2024.102575_bib250","doi-asserted-by":"crossref","first-page":"529","DOI":"10.14336\/AD.2020.0912","article-title":"Iron accumulation and lipid peroxidation in the aging retina: implication of ferroptosis in age-related macular degeneration","volume":"12","author":"Zhao","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2024.102575_bib251","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s40164-023-00427-w","article-title":"Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy","volume":"12","author":"Zheng","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.arr.2024.102575_bib252","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s11357-021-00387-1","article-title":"Interactive effects of aging and aerobic capacity on energy metabolism\u2013related metabolites of serum, skeletal muscle, and white adipose tissue","volume":"43","author":"Zhuang","year":"2021","journal-title":"GeroScience"},{"key":"10.1016\/j.arr.2024.102575_bib253","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/604658","article-title":"The role of oxidative stress-induced epigenetic alterations in amyloid-\u03b2 production in Alzheimer\u2019s disease","volume":"2015","author":"Zuo","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2024.102575_bib254","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9961628","article-title":"Ferritinophagy-mediated ferroptosis involved in paraquat-induced neurotoxicity of dopaminergic neurons: implication for neurotoxicity in PD","volume":"2021","author":"Zuo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724003933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163724003933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T22:20:53Z","timestamp":1733005253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163724003933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":254,"alternative-id":["S1568163724003933"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102575","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102575"}}