{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:36Z","timestamp":1788386076746,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.arr.2024.102645","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T17:16:42Z","timestamp":1734542202000},"page":"102645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Association of chronic exercise with markers of cardiometabolic health: a\u00a0systematic review and\u00a0meta-analysis"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-289X","authenticated-orcid":false,"given":"Nicola","family":"Veronese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna Ilarj","family":"Burgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mandal\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Saguto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia J.","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Barbagallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2024.102645_bib1","first-page":"60","article-title":"Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease","volume":"1","author":"Badimon","year":"2012","journal-title":"Eur. Heart J.: Acute Cardiovasc. Care"},{"key":"10.1016\/j.arr.2024.102645_bib2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.arr.2024.102645_bib3","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep."},{"key":"10.1016\/j.arr.2024.102645_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.ED000142","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for systematic reviews of interventions","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev. 10"},{"key":"10.1016\/j.arr.2024.102645_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot\u2013based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.arr.2024.102645_bib6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj"},{"key":"10.1016\/j.arr.2024.102645_bib7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/jappl.1997.83.1.160","article-title":"Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: A meta-analysis","volume":"83","author":"Fitzgerald","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.arr.2024.102645_bib8","article-title":"Interventions to promote cardiometabolic health and slow cardiovascular ageing","volume":"1","author":"Fontana","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2024.102645_bib9","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1152\/ajpendo.00102.2007","article-title":"Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial","volume":"293","author":"Fontana","year":"2007","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"10.1016\/j.arr.2024.102645_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11357-009-9118-z","article-title":"Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production","volume":"32","author":"Fontana","year":"2010","journal-title":"Age"},{"key":"10.1016\/j.arr.2024.102645_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.arr.2024.102645_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Bmj"},{"key":"10.1016\/j.arr.2024.102645_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/cphy.c100052","article-title":"Regulation of mitochondrial biogenesis and GLUT4 expression by exercise","author":"Holloszy","year":"2011","journal-title":"Compr. Physiol. 1"},{"key":"10.1016\/j.arr.2024.102645_bib14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00125-020-05335-w","article-title":"Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity","volume":"64","author":"Houzelle","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2024.102645_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.arr.2024.102645_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1538-7836.2007.02483.x","article-title":"Plaque progression and regression in atherothrombosis","volume":"5","author":"Ibanez","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.arr.2024.102645_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/1941126X.2018.1444339","article-title":"Rayyan for systematic reviews","volume":"30","author":"Johnson","year":"2018","journal-title":"J. Electron. Resour. Librariansh."},{"key":"10.1016\/j.arr.2024.102645_bib18","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/S0140-6736(17)30752-3","article-title":"Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study","volume":"389","author":"Kaplan","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2024.102645_bib19","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1249\/MSS.0000000000001935","article-title":"Sedentary behavior and health: update from the 2018 physical activity guidelines advisory committee","volume":"51","author":"Katzmarzyk","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.arr.2024.102645_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1249\/JES.0000000000000151","article-title":"The Microvasculature and Skeletal Muscle Health in Aging","volume":"46","author":"Landers-Ramos","year":"2018","journal-title":"Exerc Sport Sci. Rev."},{"key":"10.1016\/j.arr.2024.102645_bib21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2024.102645_bib22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCULATIONAHA.121.058162","article-title":"Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults","volume":"146","author":"Lee","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2024.102645_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0140-6736(98)10279-9","article-title":"Lifetime risk of developing coronary heart disease","volume":"353","author":"Lloyd-Jones","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2024.102645_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/CIRCULATIONAHA.105.548206","article-title":"Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age","volume":"113","author":"Lloyd-Jones","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2024.102645_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","article-title":"Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale","volume":"5","author":"Luchini","year":"2017","journal-title":"World J. Meta-Anal."},{"key":"10.1016\/j.arr.2024.102645_bib26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1056\/NEJMoa021067","article-title":"Walking compared with vigorous exercise for the prevention of cardiovascular events in women","volume":"347","author":"Manson","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2024.102645_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.arr.2018.04.007","article-title":"Muscle morphology and performance in master athletes: A systematic review and meta-analyses","volume":"45","author":"McKendry","year":"2018","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2024.102645_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40292-018-0252-5","article-title":"The Role of Renin-Angiotensin-Aldosterone System and Its New Components in Arterial Stiffness and Vascular Aging","volume":"25","author":"Neves","year":"2018","journal-title":"High. Blood Press Cardiovasc Prev."},{"key":"10.1016\/j.arr.2024.102645_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jamainternmed.2016.8014","article-title":"Association of \u201cweekend warrior\u201d and other leisure time physical activity patterns with risks for all-cause, cardiovascular disease, and cancer mortality","volume":"177","author":"O\u2019Donovan","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.arr.2024.102645_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.arr.2024.102645_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/gerona\/61.9.943","article-title":"One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue","volume":"61","author":"Racette","year":"2006","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.arr.2024.102645_bib32","doi-asserted-by":"crossref","first-page":"H1174","DOI":"10.1152\/ajpheart.01236.2007","article-title":"The effects of caloric restriction-and exercise-induced weight loss on left ventricular diastolic function","volume":"294","author":"Riordan","year":"2008","journal-title":"Am. J. Physiol. -Heart Circ. Physiol."},{"key":"10.1016\/j.arr.2024.102645_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7326\/0003-4819-133-2-200007180-00008","article-title":"Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial","volume":"133","author":"Ross","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.arr.2024.102645_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/oby.2004.95","article-title":"Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial","volume":"12","author":"Ross","year":"2004","journal-title":"Obes. Res."},{"key":"10.1016\/j.arr.2024.102645_bib35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.7326\/M14-1189","article-title":"Effects of exercise amount and intensity on abdominal obesity and glucose tolerance in obese adults: a randomized trial","volume":"162","author":"Ross","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.arr.2024.102645_bib36","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2024.102645_bib37","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1474-9726.2012.00825.x","article-title":"Caloric restriction may reverse age-related autonomic decline in humans","volume":"11","author":"Stein","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2024.102645_bib38","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1152\/ajpendo.00475.2001","article-title":"Exercise training increases lipid metabolism gene expression in human skeletal muscle","volume":"283","author":"Tunstall","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2024.102645_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s40279-019-01252-0","article-title":"Lifelong Endurance Exercise as a Countermeasure Against Age-Related [Formula: see text] Decline: Physiological Overview and Insights from Masters Athletes","volume":"50","author":"Valenzuela","year":"2020","journal-title":"Sports Med"},{"key":"10.1016\/j.arr.2024.102645_bib40","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1093\/eurheartj\/ehad170","article-title":"Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation","volume":"44","author":"Valenzuela","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.arr.2024.102645_bib41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.ade4961","article-title":"Aging impairs the neurovascular interface in the heart","volume":"381","author":"Wagner","year":"2023","journal-title":"Sci. (N. Y., N. Y. )"},{"key":"10.1016\/j.arr.2024.102645_bib42","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/84.5.1033","article-title":"Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial","volume":"84","author":"Weiss","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.arr.2024.102645_bib43","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P., 2000. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Oxford."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372400463X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156816372400463X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T16:58:20Z","timestamp":1738861100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156816372400463X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S156816372400463X"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2024.102645","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of chronic exercise with markers of cardiometabolic health: a\u00a0systematic review and\u00a0meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2024.102645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102645"}}