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Neurosci."},{"key":"10.1016\/j.arr.2025.102669_bib70","first-page":"14","article-title":"The influence of size, shape and vessel geometry on nanoparticle distribution","author":"J","year":"2013","journal-title":"Microfluid. nanofluidics"},{"key":"10.1016\/j.arr.2025.102669_bib71","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-019-0903-2","article-title":"Altered human oligodendrocyte heterogeneity in multiple sclerosis","volume":"566","author":"J\u00e4kel","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102669_bib72","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/00001756-200308060-00005","article-title":"Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo","volume":"14","author":"Jantaratnotai","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.arr.2025.102669_bib73","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s11481-013-9480-6","article-title":"Immune players in the CNS: the astrocyte","volume":"8","author":"Jensen","year":"2013","journal-title":"J. Neuroimmune Pharm."},{"key":"10.1016\/j.arr.2025.102669_bib74","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/ja808033w","article-title":"Potential oxidative stress of gold nanoparticles by induced-NO releasing in serum","volume":"131","author":"Jia","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.arr.2025.102669_bib75","article-title":"Lipid nanoparticles optimized for targeting and release of nucleic acid","volume":"36","author":"Jia","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.arr.2025.102669_bib76","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12951-022-01434-5","article-title":"Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications","volume":"20","author":"Jiang","year":"2022","journal-title":"J. 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Lett."},{"key":"10.1016\/j.arr.2025.102669_bib79","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/10717544.2018.1428243","article-title":"Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer\u2019s disease","volume":"25","author":"Karthivashan","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.arr.2025.102669_bib80","first-page":"1003","article-title":"Neuroinflammation induces neurodegeneration","volume":"1","author":"Kempuraj","year":"2016","journal-title":"J. Neurol. Neurosurg. Spine"},{"key":"10.1016\/j.arr.2025.102669_bib81","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/s41593-022-01104-7","article-title":"A shared disease-associated oligodendrocyte signature among multiple CNS pathologies","volume":"25","author":"Kenigsbuch","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102669_bib82","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2369-14-96","article-title":"An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity","volume":"14","author":"Kermanizadeh","year":"2013","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.arr.2025.102669_bib83","doi-asserted-by":"crossref","unstructured":"Kettenmann, H., Verkhratsky, A., Noda, M., Hanisch, U.-K., n.d. 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Observation of tunable band gap and anisotropic Dirac semimetal state in black phosphorus","volume":"349","author":"Kim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102669_bib86","doi-asserted-by":"crossref","first-page":"18232","DOI":"10.3390\/molecules191118232","article-title":"Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-\u03baB inactivation","volume":"19","author":"Kim","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102669_bib87","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(02)00066-6","article-title":"Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta","volume":"321","author":"Kim","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2025.102669_bib88","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1038\/s41467-021-22479-4","article-title":"Therapeutic B-cell depletion reverses progression of Alzheimer\u2019s disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102669_bib89","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N. Y)"},{"key":"10.1016\/j.arr.2025.102669_bib90","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer\u2019s disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2025.102669_bib91","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ultrasmedbio.2015.10.009","article-title":"Safety Validation of repeated blood\u2013brain barrier disruption using focused ultrasound","volume":"42","author":"Kobus","year":"2016","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.arr.2025.102669_bib92","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/brain\/awr014","article-title":"Enhancing remyelination in disease--can we wrap it up?","volume":"134","author":"Kotter","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102669_bib93","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2013.08.008","article-title":"Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?","volume":"71","author":"Kreuter","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2025.102669_bib94","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.3390\/ijms222010952","article-title":"Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations","volume":"22","author":"Kus-Li\u015bkiewicz","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102669_bib95","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2025.102669_bib96","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abe5fa","article-title":"Biocompatibility of nanomaterials and their immunological properties","volume":"16","author":"Kyriakides","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.arr.2025.102669_bib97","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/jat.3477","article-title":"Graphene and carbon nanotubes activate different cell surface receptors on macrophages before and after deactivation of endotoxins","volume":"37","author":"Lahiani","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.arr.2025.102669_bib98","doi-asserted-by":"crossref","DOI":"10.1166\/jbn.2016.2315","article-title":"Gold nanoparticles compromise TNF-\u03b1-induced endothelial cell adhesion molecule expression through nf-\u03bab and protein degradation pathways and reduce neointima formation in a rat carotid balloon injury model","volume":"12","author":"Lai","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.arr.2025.102669_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202106682","article-title":"Light-triggered efficient sequential drug delivery of biomimetic nanosystem for multimodal chemo-, antiangiogenic, and anti-MDSC therapy in melanoma","volume":"34","author":"Lai","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.arr.2025.102669_bib100","doi-asserted-by":"crossref","first-page":"25800","DOI":"10.1073\/pnas.2008762117","article-title":"Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer\u2019s disease","volume":"117","author":"Lau","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102669_bib101","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1742-2094-7-56","article-title":"LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice","volume":"7","author":"Lee","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2025.102669_bib102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200307017","article-title":"Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway","volume":"164","author":"Lee","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2025.102669_bib103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2025.102669_bib104","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41593-020-00764-7","article-title":"Molecular characterization of selectively vulnerable neurons in Alzheimer\u2019s disease","volume":"24","author":"Leng","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102669_bib105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/17435390.2018.1550226","article-title":"Silver nanoparticles induce protective autophagy via Ca2+\u2009\/CaMKK\u03b2\/AMPK\/mTOR pathway in SH-SY5Y cells and rat brains","volume":"13","author":"Li","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.arr.2025.102669_bib106","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.actbio.2021.05.019","article-title":"The protein corona and its effects on nanoparticle-based drug delivery systems","volume":"129","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2025.102669_bib107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NF\u03baB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102669_bib108","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jnc.13424","article-title":"Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer\u2019s disease","volume":"136","author":"Lian","year":"2016","journal-title":"J. Neurochem"},{"key":"10.1016\/j.arr.2025.102669_bib109","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2025.102669_bib110","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102669_bib111","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte Crosstalk in CNS Inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102669_bib112","doi-asserted-by":"crossref","DOI":"10.34133\/2022\/9847612","article-title":"Glymphatic system and subsidiary pathways drive nanoparticles away from the brain","volume":"2022","author":"Liu","year":"2022","journal-title":"Research"},{"key":"10.1016\/j.arr.2025.102669_bib113","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.2147\/IJN.S199781","article-title":"Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-\u03baB and JAK\/STAT pathways in RAW 264.7 macrophages","volume":"14","author":"Liu","year":"2019","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.arr.2025.102669_bib114","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2012.10.039","article-title":"Investigation of the performance of PEG-PEI\/ROCK-II-siRNA complexes for Alzheimer\u2019s disease in vitro","volume":"1490","author":"Liu","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2025.102669_bib115","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1093\/brain\/awh531","article-title":"LPS receptor (CD14): a receptor for phagocytosis of Alzheimer\u2019s amyloid peptide","volume":"128","author":"Liu","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102669_bib116","doi-asserted-by":"crossref","first-page":"19060","DOI":"10.1039\/C5NR06282A","article-title":"Graphene quantum dots for the inhibition of \u03b2 amyloid aggregation","volume":"7","author":"Liu","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.arr.2025.102669_bib117","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.1016\/j.biomaterials.2013.05.021","article-title":"The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2025.102669_bib118","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/WNR.0000000000001752","article-title":"PEG-PEI\/siROCK2 inhibits A\u03b242-induced microglial inflammation via NLRP3\/caspase 1 pathway","volume":"33","author":"Liu","year":"2022","journal-title":"NeuroReport"},{"key":"10.1016\/j.arr.2025.102669_bib119","first-page":"10","article-title":"Gold nanozymes: from concept to biomedical applications","volume":"13","author":"Lou-Franco","year":"2020","journal-title":"Nanomicro Lett."},{"key":"10.1016\/j.arr.2025.102669_bib120","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5762431","article-title":"Recent progress on nanostructures for drug delivery applications","volume":"2016","author":"Lu","year":"2016","journal-title":"J. Nanomater."},{"key":"10.1016\/j.arr.2025.102669_bib121","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.arr.2012.06.002","article-title":"Viewpoint: crosstalks between neurofibrillary tangles and amyloid plaque formation","volume":"12","author":"Luan","year":"2013","journal-title":"Ageing Res. Rev., Spec. Issue.: Invertebr. Models Aging"},{"key":"10.1016\/j.arr.2025.102669_bib122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2047-9158-1-9","article-title":"The changing phenotype of microglia from homeostasis to disease","volume":"1","author":"Luo","year":"2012","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2025.102669_bib123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2013.10.004","article-title":"Neuroinflammation: the role and consequences","volume":"79","author":"Lyman","year":"2014","journal-title":"Neurosci. Res"},{"key":"10.1016\/j.arr.2025.102669_bib124","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800320","article-title":"Redox-activated near-infrared-responsive polyoxometalates used for photothermal treatment of Alzheimer\u2019s Disease","volume":"7","author":"Ma","year":"2018","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.arr.2025.102669_bib125","doi-asserted-by":"crossref","DOI":"10.1007\/s12264-024-01261-8","article-title":"A new acquaintance of oligodendrocyte precursor cells in the central nervous system","author":"Ma","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.arr.2025.102669_bib126","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly Lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.arr.2025.102669_bib127","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4155\/tde-2018-0033","article-title":"Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration","volume":"9","author":"Mamo","year":"2018","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.arr.2025.102669_bib128","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.aaf6463","article-title":"Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system","volume":"352","author":"Marques","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102669_bib129","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.addr.2007.11.010","article-title":"Poly (amino acid) micelle nanocarriers in preclinical and clinical studies","volume":"60","author":"Matsumura","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.arr.2025.102669_bib130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. 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Drug Discov."},{"key":"10.1016\/j.arr.2025.102669_bib134","doi-asserted-by":"crossref","first-page":"56535","DOI":"10.1021\/acsami.2c16336","article-title":"Multifunctional architectures of cyclic dipeptide copolymers and composites, and modulation of multifaceted amyloid-\u03b2 toxicity","volume":"14","author":"Moorthy","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.arr.2025.102669_bib135","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/nen.0b013e31812503e1","article-title":"Common inflammatory mechanisms in Lewy body disease and Alzheimer disease","volume":"66","author":"Mrak","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102669_bib136","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jsps.2011.04.001","article-title":"Nanoparticles: Emerging carriers for drug delivery","volume":"19","author":"Mudshinge","year":"2011","journal-title":"Saudi Pharm. 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