{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:27:18Z","timestamp":1779377238299,"version":"3.53.1"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.arr.2025.102690","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T22:09:24Z","timestamp":1739311764000},"page":"102690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["News from the old: Aging features in the intracardiac, musculoskeletal, and enteric nervous systems"],"prefix":"10.1016","volume":"105","author":[{"given":"Severin","family":"Haider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Sassu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Stefanovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew R.","family":"Stoyek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Preissl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hortells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2025.102690_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13395-016-0101-y","article-title":"Failed reinnervation in aging skeletal muscle","volume":"6","author":"Aare","year":"2016","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.arr.2025.102690_bib2","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s43587-023-00519-6","article-title":"Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology","volume":"3","author":"Aguado","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102690_bib3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/cne.21431","article-title":"Degeneration of vagal efferent axons and terminals in cardiac ganglia of aged rats","volume":"504","author":"Ai","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.arr.2025.102690_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016955","article-title":"Behaviour of telomere and telomerase during aging and regeneration in zebrafish","volume":"6","author":"Anchelin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2025.102690_bib5","first-page":"1635","article-title":"Neurocardiology: structure-based function","author":"Ardell","year":"2016","journal-title":"Compr. Physiol. 6"},{"key":"10.1016\/j.arr.2025.102690_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2016.07.033","article-title":"Short-term dietary restriction in old zebrafish changes cell senescence mechanisms","volume":"334","author":"Arslan-Ergul","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2025.102690_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14038","article-title":"Calorie restriction reduces biomarkers of cellular senescence in humans","volume":"23","author":"Aversa","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00441-011-1130-9","article-title":"Evidence for neural progenitor cells in the human adult enteric nervous system","volume":"344","author":"Azan","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.arr.2025.102690_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/glia.24272","article-title":"Effect of old age on the subpopulations of enteric glial cells in human descending colon","volume":"71","author":"Baidoo","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.arr.2025.102690_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102690_bib11","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1002\/(SICI)1097-4598(1997)5+<83::AID-MUS20>3.0.CO;2-Z","article-title":"Age-related changes in neuromuscular innervation","volume":"5","author":"Balice-Gordon","year":"1997","journal-title":"Muscle Nerve Suppl."},{"key":"10.1016\/j.arr.2025.102690_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-009-0852-4","article-title":"ChAT and NOS in human myenteric neurons: co-existence and co-absence","volume":"338","author":"Beck","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.arr.2025.102690_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/gutjnl-2016-312940","article-title":"Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system","volume":"67","author":"Becker","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.arr.2025.102690_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0736-5748(95)00005-2","article-title":"Innervation of the rat gastrointestinal sphincters: changes during development and aging","volume":"13","author":"Belai","year":"1995","journal-title":"Int J. Dev. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2008.01245.x","article-title":"Effect of age on the enteric nervous system of the human colon","volume":"21","author":"Bernard","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.arr.2025.102690_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00418-013-1078-9","article-title":"Substance P- and choline acetyltransferase immunoreactivities in somatostatin-containing, human submucosal neurons","volume":"140","author":"Beyer","year":"2013","journal-title":"Histochem Cell Biol."},{"key":"10.1016\/j.arr.2025.102690_bib17","first-page":"158","article-title":"Aging and cardiac fibrosis","volume":"2","author":"Biernacka","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2025.102690_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0006-8993(72)90398-8","article-title":"Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence","volume":"43","author":"Bignami","year":"1972","journal-title":"Brain Res"},{"key":"10.1016\/j.arr.2025.102690_bib19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0896-6273(02)00825-5","article-title":"Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity","volume":"35","author":"Bixby","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102690_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1113\/EP090765","article-title":"Proprioceptors in extraocular muscles","volume":"109","author":"Blumer","year":"2024","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib21","article-title":"Development, diversity, and neurogenic capacity of enteric glia","volume":"9","author":"Boesmans","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2025.102690_bib22","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1113\/jphysiol.2009.169417","article-title":"Direct evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation","volume":"587","author":"Brack","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/cvr\/cvr105","article-title":"Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation","volume":"91","author":"Brack","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arr.2025.102690_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00418-021-02002-y","article-title":"Classification of human enteric neurons","volume":"156","author":"Brehmer","year":"2021","journal-title":"Histochem Cell Biol."},{"key":"10.1016\/j.arr.2025.102690_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1172\/JCI1113","article-title":"Cardiac muscarinic receptors decrease with age. In vitro and in vivo studies","volume":"101","author":"Brodde","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2025.102690_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102690_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12833","article-title":"Inflammaging impairs peripheral nerve maintenance and regeneration","volume":"17","author":"Buttner","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib28","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41467-023-36454-8","article-title":"Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals","volume":"14","author":"Cao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102690_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.168448","article-title":"Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans","volume":"8","author":"Castro","year":"2023","journal-title":"JCI Insight"},{"issue":"Pt 4","key":"10.1016\/j.arr.2025.102690_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1046\/j.1469-7580.1999.19540563.x","article-title":"Morphometric and ultrastructural changes with ageing in mouse peripheral nerve","volume":"195","author":"Ceballos","year":"1999","journal-title":"J. Anat."},{"key":"10.1016\/j.arr.2025.102690_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11210-3","article-title":"The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3","volume":"7","author":"Chadda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102690_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.arr.2018.09.005","article-title":"Ageing, the autonomic nervous system and arrhythmia: from brain to heart","volume":"48","author":"Chadda","year":"2018","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102690_bib33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0165-1838(98)00173-8","article-title":"Nitric oxide inhibits the positive chronotropic and inotropic responses to sympathetic nerve stimulation in the isolated guinea-pig atria","volume":"75","author":"Choate","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.arr.2025.102690_bib34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.mad.2010.09.001","article-title":"Life-long caloric restriction: Effect on age-related changes in motoneuron numbers, sizes and apoptotic markers","volume":"131","author":"Chopek","year":"2010","journal-title":"Mech. Ageing Dev."},{"issue":"1985","key":"10.1016\/j.arr.2025.102690_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1152\/japplphysiol.90401.2008","article-title":"Decreased maximal heart rate with aging is related to reduced beta-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate","volume":"105","author":"Christou","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/glia.22795","article-title":"The enteric glia: identity and functions","volume":"63","author":"Coelho-Aguiar Jde","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.arr.2025.102690_bib37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/gut.47.5.653","article-title":"Restricted diet rescues rat enteric motor neurones from age related cell death","volume":"47","author":"Cowen","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.arr.2025.102690_bib38","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.immuni.2022.08.005","article-title":"Macrophages in the gut: masters in multitasking","volume":"55","author":"Delfini","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2025.102690_bib39","article-title":"Aging and injury drive neuronal senescence in the dorsal root ganglia","author":"Donovan","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.arr.2025.102690_bib40","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cell.2020.08.003","article-title":"The human and mouse enteric nervous system at single-cell resolution","volume":"182","author":"Drokhlyansky","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102690_bib41","first-page":"549","article-title":"Aging is associated with cardiac autonomic nerve fiber depletion and reduced cardiac and circulating BDNF levels","volume":"18","author":"Elia","year":"2021","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.arr.2025.102690_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0047-6374(98)00142-0","article-title":"Age-induced changes in the enteric nervous system in the mouse","volume":"107","author":"El-Salhy","year":"1999","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2025.102690_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13415","article-title":"Exercise reduces circulating biomarkers of cellular senescence in humans","volume":"20","author":"Englund","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib44","first-page":"R278","article-title":"Aging effects on human sympathetic neuronal function","volume":"268","author":"Esler","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib45","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvq029","article-title":"Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3","volume":"87","author":"Fabritz","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arr.2025.102690_bib46","article-title":"The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction","volume":"7","author":"Fedele","year":"2020","journal-title":"J. Cardiovasc Dev. Dis."},{"key":"10.1016\/j.arr.2025.102690_bib47","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15587","article-title":"Aging affects the number and morphological heterogeneity of rat phrenic motor neurons and phrenic motor axons","volume":"11","author":"Fogarty","year":"2023","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.arr.2025.102690_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/jn.00061.2019","article-title":"Diaphragm neuromuscular transmission failure in aged rats","volume":"122","author":"Fogarty","year":"2019","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.arr.2025.102690_bib49","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1113\/JP276396","article-title":"Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation","volume":"596","author":"Francis Stuart","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib50","first-page":"126","article-title":"Age-related attenuation of parasympathetic control of the heart in mice","volume":"7","author":"Freeling","year":"2015","journal-title":"Int J. Physiol. Pathophysiol. Pharm."},{"key":"10.1016\/j.arr.2025.102690_bib51","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202317907","article-title":"Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury","volume":"15","author":"Fuentes-Flores","year":"2023","journal-title":"EMBO Mol. Med"},{"key":"10.1016\/j.arr.2025.102690_bib52","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cell.2015.12.023","article-title":"Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages","volume":"164","author":"Gabanyi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102690_bib53","first-page":"69","article-title":"Fine structure of the myenteric plexus in the guinea-pig ileum","volume":"111","author":"Gabella","year":"1972","journal-title":"J. Anat."},{"key":"10.1016\/j.arr.2025.102690_bib54","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/0016-5085(89)90516-7","article-title":"Fall in the number of myenteric neurons in aging guinea pigs","volume":"96","author":"Gabella","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arr.2025.102690_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/0165-1838(90)90103-P","article-title":"On the plasticity of form and structure of enteric ganglia","volume":"30","author":"Gabella","year":"1990","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.arr.2025.102690_bib56","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1111\/nmo.12114","article-title":"Myenteric neuron numbers are maintained in aging mouse distal colon","volume":"25","author":"Gamage","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.arr.2025.102690_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58591","article-title":"Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)","volume":"10","author":"Gerber","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102690_bib58","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.18632\/aging.204204","article-title":"Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis","volume":"14","author":"Gil","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2025.102690_bib59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11357-018-0020-4","article-title":"Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health","volume":"40","author":"Gillon","year":"2018","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2025.102690_bib60","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/mus.25982","article-title":"Effect of very old age on anconeus motor unit loss and compensatory remodelling","volume":"57","author":"Gilmore","year":"2018","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.arr.2025.102690_bib61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000213852","article-title":"A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon","volume":"43","author":"Gomes","year":"1997","journal-title":"Gerontology"},{"key":"10.1016\/j.arr.2025.102690_bib62","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mcn.2004.06.010","article-title":"The role of proteoglycans in Schwann cell\/astrocyte interactions and in regeneration failure at PNS\/CNS interfaces","volume":"28","author":"Grimpe","year":"2005","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib63","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrgastro.2012.138","article-title":"Novel functional roles for enteric glia in the gastrointestinal tract","volume":"9","author":"Gulbransen","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.arr.2025.102690_bib64","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.arr.2025.102690_bib65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jns.2016.09.021","article-title":"Oxidative damage to myelin proteins accompanies peripheral nerve motor dysfunction in aging C57BL\/6 male mice","volume":"370","author":"Hamilton","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.autneu.2004.05.007","article-title":"Age-related changes in the morphology of the myenteric plexus of the human colon","volume":"113","author":"Hanani","year":"2004","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032677","article-title":"Age-related changes in neurons and satellite glial cells in mouse dorsal root ganglia","volume":"24","author":"Hanani","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib68","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cne.902690309","article-title":"Medial gastrocnemius motor nucleus in the rat: age-related changes in the number and size of motoneurons","volume":"269","author":"Hashizume","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.arr.2025.102690_bib69","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1586\/erc.11.112","article-title":"Aging is a primary risk factor for cardiac arrhythmias: disruption of intracellular Ca2+\u2009regulation as a key suspect","volume":"9","author":"Hatch","year":"2011","journal-title":"Expert Rev. Cardiovasc Ther."},{"key":"10.1016\/j.arr.2025.102690_bib70","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/eurheartj\/ehi825","article-title":"Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study","volume":"27","author":"Heeringa","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.arr.2025.102690_bib71","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fnagi.2014.00276","article-title":"Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection","volume":"6","author":"Hetz","year":"2014","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib72","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.1073\/pnas.2009119117","article-title":"A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation","volume":"117","author":"Hortells","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102690_bib73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fcvm.2018.00027","article-title":"Cell phenotype transitions in cardiovascular calcification","volume":"5","author":"Hortells","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.arr.2025.102690_bib74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yjmcc.2021.02.001","article-title":"Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth","volume":"154","author":"Hortells","year":"2021","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.arr.2025.102690_bib75","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/joim.13728","article-title":"Diet strategies for promoting healthy aging and longevity: An epidemiological perspective","volume":"295","author":"Hu","year":"2024","journal-title":"J. Intern Med"},{"key":"10.1016\/j.arr.2025.102690_bib76","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1007\/s10571-023-01431-8","article-title":"Genetic features of young and aged animals after peripheral nerve injury: implications for diminished regeneration capacity","volume":"43","author":"Huang","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102690_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13536","article-title":"Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation","volume":"21","author":"Ikemoto-Uezumi","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib78","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/dvdy.24611","article-title":"Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord","volume":"247","author":"Imai","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.arr.2025.102690_bib79","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.clinph.2005.08.003","article-title":"Aging of phrenic nerve conduction in the elderly","volume":"116","author":"Imai","year":"2005","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.arr.2025.102690_bib80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00418-010-0774-y","article-title":"Partial, selective survival of nitrergic neurons in chagasic megacolon","volume":"135","author":"Jabari","year":"2011","journal-title":"Histochem Cell Biol."},{"key":"10.1016\/j.arr.2025.102690_bib81","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/286736a0","article-title":"Glial cells in the enteric nervous system contain glial fibrillary acidic protein","volume":"286","author":"Jessen","year":"1980","journal-title":"Nature"},{"issue":"Pt 4","key":"10.1016\/j.arr.2025.102690_bib82","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1469-7580.1998.19240479.x","article-title":"The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine","volume":"192","author":"Johnson","year":"1998","journal-title":"J. Anat."},{"key":"10.1016\/j.arr.2025.102690_bib83","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1172\/JCI58186","article-title":"Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut","volume":"121","author":"Joseph","year":"2011","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2025.102690_bib84","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response","volume":"11","author":"Jurk","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib85","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0168-0102(86)90006-4","article-title":"The effects of aging on physiological properties of fast and slow twitch motor units in the rat gastrocnemius","volume":"3","author":"Kanda","year":"1986","journal-title":"Neurosci. Res"},{"key":"10.1016\/j.arr.2025.102690_bib86","doi-asserted-by":"crossref","first-page":"19480","DOI":"10.1523\/JNEUROSCI.4067-13.2013","article-title":"Motor axon regeneration and muscle reinnervation in young adult and aged animals","volume":"33","author":"Kang","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib87","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/00005072-197709000-00009","article-title":"Lumbar motoneurons of man: I) number and diameter histogram of alpha and gamma axons of ventral root","volume":"36","author":"Kawamura","year":"1977","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102690_bib88","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1469-8986.2009.00859.x","article-title":"Interoceptive awareness declines with age","volume":"46","author":"Khalsa","year":"2009","journal-title":"Psychophysiology"},{"key":"10.1016\/j.arr.2025.102690_bib89","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1113\/jphysiol.2007.130120","article-title":"Age-related physiological and morphological changes of muscle spindles in rats","volume":"582","author":"Kim","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib90","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1196\/annals.1297.097","article-title":"Functional aging and gradual senescence in zebrafish","volume":"1019","author":"Kishi","year":"2004","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib91","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1038\/s41598-021-85863-6","article-title":"The effects of myelin on macrophage activation are phenotypic specific via cPLA(2) in the context of spinal cord injury inflammation","volume":"11","author":"Kopper","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102690_bib92","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/CIRCULATIONAHA.123.066989","article-title":"Antiarrhythmic drug therapy: where do we go from here?","volume":"149","author":"Kowey","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2025.102690_bib93","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0896-6273(02)00827-9","article-title":"Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness","volume":"35","author":"Kruger","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102690_bib94","doi-asserted-by":"crossref","first-page":"E3709","DOI":"10.1073\/pnas.1619406114","article-title":"Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis","volume":"114","author":"Kulkarni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102690_bib95","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1172\/JCI58200","article-title":"Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury","volume":"121","author":"Laranjeira","year":"2011","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2025.102690_bib96","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2017.01.039","article-title":"Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds","volume":"75","author":"Lautenbacher","year":"2017","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.arr.2025.102690_bib97","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.conb.2017.10.010","article-title":"Schwann cells participate in synapse elimination at the developing neuromuscular junction","volume":"47","author":"Lee","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.arr.2025.102690_bib98","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0735-1097(02)02168-X","article-title":"Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart","volume":"40","author":"Leineweber","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2025.102690_bib99","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10522-021-09910-5","article-title":"Aging and age-related diseases: from mechanisms to therapeutic strategies","volume":"22","author":"Li","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2025.102690_bib100","article-title":"Prevalence and incidence of atrial fibrillation and other arrhythmias in the general older population: findings from the swedish national study on aging and care","volume":"5","author":"Lindberg","year":"2019","journal-title":"Gerontol. Geriatr. Med"},{"key":"10.1016\/j.arr.2025.102690_bib101","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1145-09.2009","article-title":"5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice","volume":"29","author":"Liu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib102","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1749-6632.2001.tb03668.x","article-title":"Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes","volume":"940","author":"Longhurst","year":"2001","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib103","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"Lopez-Otin","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102690_bib104","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-023-06680-7","article-title":"Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope","volume":"623","author":"Lovelace","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102690_bib105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2147\/CIA.S88441","article-title":"Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress","author":"Machi","year":"2016","journal-title":"Clin. Inter. Aging 11"},{"key":"10.1016\/j.arr.2025.102690_bib106","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1007\/BF01296501","article-title":"Effects of gender, age, and body mass index on gastrointestinal transit times","volume":"37","author":"Madsen","year":"1992","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib107","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/ageing\/afh040","article-title":"Effects of ageing on gastrointestinal motor function","volume":"33","author":"Madsen","year":"2004","journal-title":"Age Ageing"},{"key":"10.1016\/j.arr.2025.102690_bib108","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tcm.2020.04.011","article-title":"The role of the autonomic nervous system in cardiac arrhythmias: The neuro-cardiac axis, more foe than friend?","volume":"31","author":"Manolis","year":"2021","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.arr.2025.102690_bib109","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autneu.2007.05.003","article-title":"Alterations of the number and the profile of myenteric neurons of Wistar rats promoted by age","volume":"137","author":"Marese","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib110","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12726","article-title":". alpha-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice","volume":"17","author":"Maxwell","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102690_bib111","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.gastro.2013.10.061","article-title":"Ca2+\u2009responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice","volume":"146","author":"McClain","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arr.2025.102690_bib112","unstructured":"McCuller, C., Jessu, R. & Callahan, A.L. in StatPearls (2024)."},{"key":"10.1016\/j.arr.2025.102690_bib113","first-page":"G542","article-title":"Age-related changes in colonic function in rats","volume":"247","author":"McDougal","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib114","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neurobiolaging.2015.12.005","article-title":"Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice","volume":"39","author":"Moldovan","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2025.102690_bib115","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.cell.2014.08.002","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102690_bib116","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2982.2006.00843.x","article-title":"Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase","volume":"19","author":"Murphy","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.arr.2025.102690_bib117","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10522-023-10068-5","article-title":"Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease","volume":"25","author":"Nieto","year":"2024","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2025.102690_bib118","doi-asserted-by":"crossref","first-page":"188","DOI":"10.12968\/bjon.2006.15.4.20542","article-title":"Constipation in older patients: effects on quality of life","volume":"15","author":"Norton","year":"2006","journal-title":"Br. J. Nurs."},{"key":"10.1016\/j.arr.2025.102690_bib119","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s11357-021-00478-z","article-title":"Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults","volume":"43","author":"Orssatto","year":"2021","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2025.102690_bib120","first-page":"1306","article-title":"AAV1.NT-3 gene therapy prevents age-related sarcopenia","volume":"15","author":"Ozes","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2025.102690_bib121","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuron.2014.06.016","article-title":"Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration","volume":"83","author":"Painter","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102690_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.747067","article-title":"Expression of p16 within myenteric neurons of the aged colon: a potential marker of declining function","volume":"15","author":"Palmer","year":"2021","journal-title":"Front Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib123","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/jnrp.jnrp_323_17","article-title":"Impact of aging on nerve conduction velocities and late responses in healthy individuals","volume":"9","author":"Palve","year":"2018","journal-title":"J. Neurosci. Rural Pr."},{"key":"10.1016\/j.arr.2025.102690_bib124","doi-asserted-by":"crossref","first-page":"712","DOI":"10.18632\/aging.100926","article-title":"A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia","volume":"8","author":"Pannerec","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2025.102690_bib125","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s00018-019-03431-8","article-title":"Behind the pathology of macrophage-associated demyelination in inflammatory neuropathies: demyelinating Schwann cells","volume":"77","author":"Park","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102690_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2007.04.005","article-title":"Innervation of the gastrointestinal tract: patterns of aging","volume":"136","author":"Phillips","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib127","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1566-0702(03)00072-9","article-title":"Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons","volume":"106","author":"Phillips","year":"2003","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00429-004-0426-x","article-title":"Loss of glia and neurons in the myenteric plexus of the aged Fischer 344 rat","volume":"209","author":"Phillips","year":"2004","journal-title":"Anat. Embryol. (Berl. )"},{"key":"10.1016\/j.arr.2025.102690_bib129","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1113\/JP276200","article-title":"Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery","volume":"597","author":"Pianca","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11357-021-00506-y","article-title":"Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice","volume":"44","author":"Piekarz","year":"2022","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2025.102690_bib131","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gut.51.1.70","article-title":"Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon","volume":"51","author":"Porter","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.arr.2025.102690_bib132","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/cne.902520406","article-title":"Colonization of the bowel by the precursors of enteric glia: studies of normal and congenitally aganglionic mutant mice","volume":"252","author":"Rothman","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.arr.2025.102690_bib133","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ydbio.2013.03.015","article-title":"Cellular changes in the enteric nervous system during ageing","volume":"382","author":"Saffrey","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.arr.2025.102690_bib134","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12868-016-0277-4","article-title":"Age-related morphological regression of myelinated fibers and capillary architecture of distal peripheral nerves in rats","volume":"17","author":"Sakita","year":"2016","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1838(94)90131-7","article-title":"Survival of the population of NADPH-diaphorase stained myenteric neurons in the small intestine of aged rats","volume":"49","author":"Santer","year":"1994","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.arr.2025.102690_bib136","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0165-1838(88)90008-2","article-title":"Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats","volume":"25","author":"Santer","year":"1988","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.arr.2025.102690_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1408744","article-title":"From diversity to disease: unravelling the role of enteric glial cells","volume":"15","author":"Santhosh","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102690_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2023.12.002","article-title":"Age-related structural and functional changes of the intracardiac nervous system","volume":"187","author":"Sassu","year":"2024","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.arr.2025.102690_bib139","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0304-3940(85)90090-4","article-title":"Aging effects on conduction velocities of myelinated and unmyelinated fibers of peripheral nerves","volume":"53","author":"Sato","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2025.102690_bib140","article-title":"Enteric glial hub cells coordinate intestinal motility","author":"Scavuzzo","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.arr.2025.102690_bib141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.05.004","article-title":"An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats","volume":"45","author":"Scheib","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2025.102690_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101393","article-title":"Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology","volume":"70","author":"Selman","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102690_bib143","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0531-5565(96)00029-0","article-title":"Influence of aging on gastric emptying of liquids, small intestine transit, and fecal output in rats","volume":"31","author":"Smits","year":"1996","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102690_bib144","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000213532","article-title":"Age-induced nerve cell loss in the myenteric plexus of the small intestine in man","volume":"39","author":"de Souza","year":"1993","journal-title":"Gerontology"},{"key":"10.1016\/j.arr.2025.102690_bib145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pbiomolbio.2018.07.014","article-title":"Age-associated changes in electrical function of the zebrafish heart","volume":"138","author":"Stoyek","year":"2018","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102690_bib146","article-title":"From mice to mainframes: experimental models for investigation of the intracardiac nervous system","volume":"8","author":"Stoyek","year":"2021","journal-title":"J. Cardiovasc Dev. Dis."},{"key":"10.1016\/j.arr.2025.102690_bib147","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnagi.2020.00174","article-title":"Macrophages and associated ligands in the aged injured nerve: a defective dynamic that contributes to reduced axonal regrowth","volume":"12","author":"Stratton","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib148","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.18632\/aging.101677","article-title":"Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract","volume":"10","author":"Sun","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2025.102690_bib149","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0022-510X(72)90048-2","article-title":"The effect of age on human skeletal muscle. Studies of the morphology and innervation of muscle spindles","volume":"16","author":"Swash","year":"1972","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2025.102690_bib150","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/physrev.00033.2014","article-title":"Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting","volume":"95","author":"Tintignac","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2025.102690_bib151","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/nmo.12290","article-title":"In a non-human primate model, aging disrupts the neural control of intestinal smooth muscle contractility in a region-specific manner","volume":"26","author":"Tran","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.arr.2025.102690_bib152","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jnr.1087","article-title":"Neurofilaments of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging","volume":"64","author":"Uchida","year":"2001","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.arr.2025.102690_bib153","doi-asserted-by":"crossref","first-page":"58","DOI":"10.14797\/mdcvj.1185","article-title":"The future of antiarrhythmic drug therapy: will drugs be entirely replaced by procedures?","volume":"18","author":"Valderrabano","year":"2022","journal-title":"Methodist Debakey Cardiovasc J."},{"key":"10.1016\/j.arr.2025.102690_bib154","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.619197","article-title":"Modeling neuroregeneration and neurorepair in an aging context: the power of a teleost model","volume":"9","author":"Van Houcke","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2025.102690_bib155","first-page":"771","article-title":"Impact of aging on proprioceptive sensory neurons and intrafusal muscle fibers in Mice","volume":"72","author":"Vaughan","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"key":"10.1016\/j.arr.2025.102690_bib156","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/glia.22305","article-title":"Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways","volume":"60","author":"Verdier","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.arr.2025.102690_bib157","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1529-8027.2000.00026.x","article-title":"Influence of aging on peripheral nerve function and regeneration","volume":"5","author":"Verdu","year":"2000","journal-title":"J. Peripher Nerv. Syst."},{"key":"10.1016\/j.arr.2025.102690_bib158","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1124","article-title":"Age-related molecular changes in the lumbar dorsal root ganglia of mice: signs of sensitization, and inflammatory response","volume":"3","author":"Vincent","year":"2020","journal-title":"JOR Spine"},{"key":"10.1016\/j.arr.2025.102690_bib159","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41586-023-06200-7","article-title":"Dedicated macrophages organize and maintain the enteric nervous system","volume":"618","author":"Viola","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102690_bib160","doi-asserted-by":"crossref","first-page":"G489","DOI":"10.1152\/ajpgi.00091.2002","article-title":"Aging and neural control of the GI tract. I. Age-related changes in the enteric nervous system","volume":"283","author":"Wade","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.arr.2025.102690_bib161","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.ade4961","article-title":"Aging impairs the neurovascular interface in the heart","volume":"381","author":"Wagner","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102690_bib162","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62232","article-title":"Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun","volume":"10","author":"Wagstaff","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102690_bib163","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0166-2236(98)01339-3","article-title":"Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms","volume":"22","author":"Walro","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib164","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/s41467-020-16355-w","article-title":"Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102690_bib165","article-title":"Sympathetic nervous system mediates cardiac remodeling after myocardial infarction in a circadian disruption model","volume":"8","author":"Wang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.arr.2025.102690_bib166","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11894-010-0139-7","article-title":"The aging colon: the role of enteric neurodegeneration in constipation","volume":"12","author":"Wiskur","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.arr.2025.102690_bib167","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20200026","article-title":"Macrophage immunometabolism and inflammaging: roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD","volume":"2","author":"Yarbro","year":"2020","journal-title":"Immunometabolism"},{"key":"10.1016\/j.arr.2025.102690_bib168","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41593-020-0618-6","article-title":"Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury","volume":"23","author":"Ydens","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib169","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41593-021-01005-1","article-title":"Disentangling glial diversity in peripheral nerves at single-nuclei resolution","volume":"25","author":"Yim","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib170","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1523\/JNEUROSCI.3030-17.2018","article-title":"Macrophage depletion ameliorates peripheral neuropathy in aging mice","volume":"38","author":"Yuan","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2025.102690_bib171","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd5926","article-title":"Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline","volume":"376","author":"Zhou","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102690_bib172","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13104-017-2593-x","article-title":"Simple and fast quantification of DNA damage by real-time PCR, and its application to nuclear and mitochondrial DNA from multiple tissues of aging zebrafish","volume":"10","author":"Zhu","year":"2017","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.arr.2025.102690_bib173","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725000364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725000364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:11:40Z","timestamp":1750209100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725000364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":173,"alternative-id":["S1568163725000364"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102690","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"News from the old: Aging features in the intracardiac, musculoskeletal, and enteric nervous systems","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102690","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102690"}}