{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:55:22Z","timestamp":1789498522068,"version":"build-2803163510"},"reference-count":275,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018607","name":"Henan Province Science and Technology Innovation Talent Program","doi-asserted-by":"publisher","award":["SYLYC2023092"],"award-info":[{"award-number":["SYLYC2023092"]}],"id":[{"id":"10.13039\/501100018607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271410"],"award-info":[{"award-number":["81271410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Henan Province Natural Science Foundation","doi-asserted-by":"publisher","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.arr.2025.102804","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:43:44Z","timestamp":1749843824000},"page":"102804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Synergistic pathways in Parkinson's disease: The promise of FGF21 and ACE2"],"prefix":"10.1016","volume":"110","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat. Med"},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib2","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1080\/15548627.2021.1985257","article-title":"Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice","volume":"18","author":"Ahuja","year":"2022","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib3","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.3390\/biomedicines11102735","article-title":"Effects of tiliroside and lisuride Co-treatment on the PI3K\/Akt signal pathway: modulating neuroinflammation and apoptosis in Parkinson's disease","volume":"11","author":"Alkholifi","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/life13020536","article-title":"Exploring the role of ACE2 as a connecting link between COVID-19 and Parkinson's disease","volume":"13","author":"Angelopoulou","year":"2023","journal-title":"Life"},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib5","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acschemneuro.0c00076","article-title":"GLUT-1: an effective target to deliver brain-derived neurotrophic factor gene across the blood brain barrier","volume":"11","author":"Arora","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102804_bib6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2016.01.012","article-title":"PI3K\/Akt\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives","volume":"109","author":"Asati","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.arr.2025.102804_bib7","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.3390\/ijms22094676","article-title":"The contribution of microglia to neuroinflammation in Parkinson's disease","volume":"22","author":"Badanjak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib8","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1002\/jsfa.13256","article-title":"Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPK\u03b1 pathway","volume":"104","author":"Bai","year":"2024","journal-title":"J. Sci. Food Agric."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib9","article-title":"The penetration of therapeutics across the blood-brain barrier: classic case studies and clinical implications","volume":"5","author":"Banks","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000108758","article-title":"Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats","volume":"28","author":"Benter","year":"2008","journal-title":"Am. J. Nephrol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib12","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1080\/15548627.2020.1713640","article-title":"Autophagy drives fibroblast senescence through MTORC2 regulation","volume":"16","author":"Bernard","year":"2020","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib13","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1038\/s41440-019-0321-8","article-title":"Stimulation of the ACE2\/Ang-(1-7)\/mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring","volume":"42","author":"Bessa","year":"2019","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apsb.2020.10.006","article-title":"Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator","volume":"11","author":"Bian","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004863","article-title":"Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra","volume":"10","author":"Bifsha","year":"2014","journal-title":"PLoS Genet"},{"issue":"10291","key":"10.1016\/j.arr.2025.102804_bib16","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2025.102804_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102698","article-title":"NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease","volume":"62","author":"Boonpraman","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41467-020-14384-z","article-title":"Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase","volume":"11","author":"Byun","year":"2020","journal-title":"Nat. Commun."},{"issue":"8010","key":"10.1016\/j.arr.2025.102804_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-024-07311-5","article-title":"Network-level encoding of local neurotransmitters in cortical astrocytes","volume":"629","author":"Cahill","year":"2024","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.arr.2025.102804_bib20","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1042\/CS20200477","article-title":"ACE2 and gut amino acid transport","volume":"134","author":"Camargo","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.arr.2025.102804_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111254","article-title":"Renin-angiotensin system and inflammation update","volume":"529","author":"Cantero-Navarro","year":"2021","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12944-019-1145-x","article-title":"Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism","volume":"18","author":"Cao","year":"2019","journal-title":"Lipids Health Dis."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.phrs.2008.02.001","article-title":"TGF-beta1 targets the GSK-3beta\/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts","volume":"57","author":"Caraci","year":"2008","journal-title":"Pharmacol. Res"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41531-025-00925-0","article-title":"Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection","volume":"11","author":"Chatterjee","year":"2025","journal-title":"bioRxiv [Prepr.]. NPJ Park. Dis."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib25","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1007\/s11427-021-2067-7","article-title":"CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway","volume":"65","author":"Chen","year":"2022","journal-title":"Sci. China Life Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib26","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2017.45","article-title":"Fasting-induced hormonal regulation of lysosomal function","volume":"27","author":"Chen","year":"2017","journal-title":"Cell Res."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.17219\/acem\/133494","article-title":"FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-\u03b1-mediated VEGFA and ERK1\/2 signaling pathway","volume":"30","author":"Chen","year":"2021","journal-title":"Adv. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12967-023-04369-z","article-title":"Mitochondrial dysfunction: roles in skeletal muscle atrophy","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41392-021-00740-y","article-title":"ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jmv.25785","article-title":"Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19","volume":"92","author":"Cheng","year":"2020","journal-title":"J. Med. Virol."},{"issue":"7960","key":"10.1016\/j.arr.2025.102804_bib31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41586-023-06010-x","article-title":"Inhibitory input directs astrocyte morphogenesis through glial GABABR","volume":"617","author":"Cheng","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib32","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.arr.2025.102804_bib33","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1021\/acs.jafc.2c07606","article-title":"A low-protein, high-carbohydrate diet exerts a neuroprotective effect on mice with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease by regulating the microbiota-metabolite-brain axis and fibroblast growth factor 21","volume":"71","author":"Chu","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71569-8","article-title":"Genome-wide association study for circulating fibroblast growth factor 21 and 23","volume":"10","author":"Chuang","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tem.2024.02.001","article-title":"Current status and future perspectives of FGF21 analogues in clinical trials","volume":"35","author":"Chui","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13480","article-title":"Activation of angiotensin-converting enzyme 2\/angiotensin (1-7)\/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling","volume":"20","author":"Dang","year":"2021","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","article-title":"Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications","volume":"15","author":"Dash","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.arr.2025.102804_bib39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbrc.2023.01.012","article-title":"FOXO1 represses PPAR\u03b1-Mediated induction of FGF21 gene expression","volume":"644","author":"De Sousa-Coelho","year":"2023","journal-title":"Biochem. Biophys. Res Commun."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib40","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3390\/medicina59101756","article-title":"Cognitive impairment in Parkinson's disease: an updated overview focusing on emerging pharmaceutical treatment approaches","volume":"59","author":"Degirmenci","year":"2023","journal-title":"Medicina"},{"issue":"23","key":"10.1016\/j.arr.2025.102804_bib41","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1038\/onc.2013.266","article-title":"PDK1 controls upstream PI3K expression and PIP3 generation","volume":"33","author":"Dieterle","year":"2014","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.conb.2007.04.010","article-title":"Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease","volume":"17","author":"Dodson","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib43","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.7150\/ijbs.81498","article-title":"ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1\u03b1 activity","volume":"19","author":"Dong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41392-023-01353-3","article-title":"Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions","volume":"8","author":"Dong-Chen","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib45","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1038\/s41467-021-25331-x","article-title":"A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants","volume":"12","author":"Du","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib46","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1152\/ajpendo.00791.2007","article-title":"Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K\/Akt, Bcl-2, and phospho-Bad signaling","volume":"294","author":"Dufour","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib47","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1007\/s12035-024-04549-y","article-title":"FGF21 alleviates hypoxic-ischemic white matter injury in neonatal mice by mediating inflammation and oxidative stress through PPAR-\u03b3 signaling pathway","volume":"62","author":"Fang","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib48","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s12640-019-00151-6","article-title":"FGF21 protects dopaminergic neurons in Parkinson's disease models via repression of neuroinflammation","volume":"37","author":"Fang","year":"2020","journal-title":"Neurotox. Res."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib49","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141848","article-title":"Age-related GSK3\u03b2 overexpression drives podocyte senescence and glomerular aging","volume":"132","author":"Fang","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib50","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/antiox11040764","article-title":"An ACE2-Alamandine Axis Modulates the Cardiac Performance of the Goldfish Carassius auratus via the NOS\/NO System","volume":"11","author":"Filice","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2025.102804_bib51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu Rev. Physiol."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib52","doi-asserted-by":"crossref","first-page":"G832","DOI":"10.1152\/ajpgi.00355.2015","article-title":"Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations","volume":"310","author":"Fletcher","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.arr.2025.102804_bib53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fneur.2019.00232","article-title":"Peripheral-central neuroimmune crosstalk in Parkinson's disease: what do patients and animal models tell us?","volume":"10","author":"Fuzzati-Armentero","year":"2019","journal-title":"Front. Neurol."},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib54","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/ueg2.12534","article-title":"Fibroblast growth factor 21 is a hepatokine involved in MASLD progression","volume":"12","author":"Gallego-Dur\u00e1n","year":"2024","journal-title":"U. Eur. Gastroenterol. J."},{"issue":"21","key":"10.1016\/j.arr.2025.102804_bib55","first-page":"13304","article-title":"Angiotensin-(1-7) relieves behavioral defects and \u03b1-synuclein expression through NEAT1\/miR-153-3p axis in Parkinson's disease","volume":"16","author":"Gao","year":"2024","journal-title":"Aging"},{"key":"10.1016\/j.arr.2025.102804_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101635","article-title":"Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy","volume":"36","author":"Gao","year":"2020","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib57","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib58","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib59","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1038\/s41598-021-84850-1","article-title":"Polyunsaturated \u03c9-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry","volume":"11","author":"Goc","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ymthe.2005.03.022","article-title":"Regulatable gene expression systems for gene therapy applications: progress and future challenges","volume":"12","author":"Goverdhana","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.arr.2025.102804_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2022.104846","article-title":"The PI3K-AKT pathway: a plausible therapeutic target in Parkinson's disease","volume":"129","author":"Goyal","year":"2023","journal-title":"Exp. Mol. Pathol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13578-023-00967-y","article-title":"Ang-(1-7)\/MasR axis promotes functional recovery after spinal cord injury by regulating microglia\/macrophage polarization","volume":"13","author":"Gu","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.arr.2025.102804_bib63","first-page":"206","article-title":"Oxidative stress-induced temporal activation of ERK1\/2 phosphorylates coreceptor of Wnt\/\u03b2-catenin for myofibroblast formation in human lens epithelial cells","volume":"29","author":"Guo","year":"2023","journal-title":"Mol. Vis."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib64","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1021\/acschemneuro.1c00797","article-title":"Angiotensin-converting enzyme 2 activation mitigates behavioral deficits and neuroinflammatory burden in 6-OHDA induced experimental models of Parkinson's disease","volume":"13","author":"Gupta","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102804_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122245","article-title":"Lactoferrin ameliorates carfilzomib-induced renal and pulmonary deficits: Insights to the inflammasome NLRP3\/NF-\u03baB and PI3K\/Akt\/GSK-3\u03b2\/MAPK axes","volume":"335","author":"Habib","year":"2023","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.arr.2025.102804_bib66","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/s41401-021-00853-8","article-title":"CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK\/AKT-Nurr1 signal pathways","volume":"43","author":"Han","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.arr.2025.102804_bib67","doi-asserted-by":"crossref","first-page":"628","DOI":"10.52586\/4972","article-title":"The renin-angiotensin system in central nervous system tumors and degenerative diseases","volume":"26","author":"Haron","year":"2021","journal-title":"Front. Biosci."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib68","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.soc.2013.06.008","article-title":"Targeting the PI3-kinase\/Akt\/mTOR signaling pathway","volume":"22","author":"Hassan","year":"2013","journal-title":"Surg. Oncol. Clin. N. Am."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib69","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/08923973.2022.2143371","article-title":"Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1\/PPAR-\u03b3, SIRT1\/FOXO-3, JNK\/AP-1, TLR4\/iNOS, and Ang II\/Ang 1-7 signals","volume":"45","author":"Hassanein","year":"2023","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib70","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib71","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u03baB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.arr.2025.102804_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.110197","article-title":"Exercise as medicine for COVID-19: on PPAR with emerging pharmacotherapy","volume":"143","author":"Heffernan","year":"2020","journal-title":"Med Hypotheses"},{"issue":"22","key":"10.1016\/j.arr.2025.102804_bib73","doi-asserted-by":"crossref","first-page":"12595","DOI":"10.3390\/ijms222212595","article-title":"Pseudophosphatases as regulators of MAPK signaling","author":"Hepworth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102804_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113837","article-title":"ACE2 expression in rat brain: implications for COVID-19 associated neurological manifestations","volume":"345","author":"Hern\u00e1ndez","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102804_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116261","article-title":"A53T \u03b1-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)\/MasR axis","volume":"224","author":"Hong","year":"2024","journal-title":"Biochem Pharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib76","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuro.2024.12.003","article-title":"Smoking, coffee intake, and Parkinson's disease: Potential protective mechanisms and components","volume":"106","author":"Hong","year":"2025","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.arr.2025.102804_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.theriogenology.2022.09.020","article-title":"Fibroblast growth factor 21 (FGF21) promotes porcine granulosa cell estradiol production and proliferation via PI3K\/AKT\/mTOR signaling","volume":"194","author":"Hu","year":"2022","journal-title":"Theriogenology"},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib78","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000045","article-title":"Canagliflozin ameliorates the development of NAFLD by preventing NLRP3-mediated pyroptosis through FGF21-ERK1\/2 pathway","volume":"7","author":"Huang","year":"2023","journal-title":"Hepatol. Commun."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib79","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3892\/mmr.2020.11795","article-title":"Estrogen receptor-associated receptor \u03b1 and peroxisome proliferator-activated receptor \u03b3 in metabolism and disease","volume":"23","author":"Huang","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib80","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11906-017-0730-5","article-title":"The potential role of fibroblast growth factor 21 in lipid metabolism and hypertension","volume":"19","author":"Huang","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib81","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1177\/0271678X19878889","article-title":"Robust RBM3 and \u03b2-klotho expression in developing neurons in the human brain","volume":"39","author":"Jackson","year":"2019","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib82","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/jnr.25232","article-title":"A review of the mechanisms of blood-brain barrier disruption during COVID-19 infection","volume":"101","author":"Jamil Al-Obaidi","year":"2023","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2025.102804_bib83","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.atherosclerosis.2022.02.022","article-title":"Soluble RAGE attenuates Ang II-induced arterial calcification via inhibiting AT1R-HMGB1-RAGE axis","volume":"346","author":"Jeong","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arr.2025.102804_bib84","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cytogfr.2019.03.001","article-title":"Role of the PI3K\/AKT (mTOR and GSK3\u03b2) signalling pathway and photobiomodulation in diabetic wound healing","volume":"50","author":"Jere","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.arr.2025.102804_bib85","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jbior.2019.03.003","article-title":"Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship","volume":"72","author":"Jhanwar-Uniyal","year":"2019","journal-title":"Adv. Biol. Regul."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib86","doi-asserted-by":"crossref","first-page":"645","DOI":"10.18632\/aging.101419","article-title":"AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation","volume":"10","author":"Jiang","year":"2018","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib87","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708791","article-title":"FGF21 gene therapy as treatment for obesity and insulin resistance","volume":"10","author":"Jimenez","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"20","key":"10.1016\/j.arr.2025.102804_bib88","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/CIRCULATIONAHA.122.059631","article-title":"FGF21-sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity","volume":"146","author":"Jin","year":"2022","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib89","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1601-183X.2012.00822.x","article-title":"Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons","volume":"11","author":"Johnson","year":"2012","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.arr.2025.102804_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110145","article-title":"Fibroblast growth factor 21 and autophagy: a complex interplay in Parkinson disease","volume":"127","author":"Kakoty","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102804_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110439","article-title":"FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress","volume":"129","author":"Kang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102804_bib92","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.arr.2025.102804_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105781","article-title":"Global distribution of ACE1 (rs4646994) and ACE2 (rs2285666) polymorphisms associated with COVID-19: a systematic review and meta-analysis","volume":"172","author":"Keikha","year":"2022","journal-title":"Micro Pathog."},{"key":"10.1016\/j.arr.2025.102804_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102068","article-title":"FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling","volume":"91","author":"Khan","year":"2025","journal-title":"Mol. Metab."},{"key":"10.1016\/j.arr.2025.102804_bib95","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/bs.vh.2016.02.008","article-title":"The FGF21 receptor signaling complex: Klotho\u03b2, FGFR1c, and other regulatory interactions","volume":"101","author":"Kilkenny","year":"2016","journal-title":"Vitam. Horm."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib97","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/oby.23041","article-title":"Effects of exercise on ACE2","volume":"28","author":"Kl\u00f6ting","year":"2020","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib98","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-023-00622-7","article-title":"Neuropathology of incidental lewy body & prodromal Parkinson's disease","volume":"18","author":"Koeglsperger","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"7-8","key":"10.1016\/j.arr.2025.102804_bib99","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-023-01848-y","article-title":"Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues","volume":"28","author":"Kumari","year":"2023","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/CS20200480","article-title":"ACE2\/Ang-(1-7)\/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease","volume":"135","author":"Kuriakose","year":"2021","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib101","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib102","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41531-022-00340-9","article-title":"Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson\u00b4s disease","volume":"8","author":"Labandeira","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"10.1016\/j.arr.2025.102804_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109813","article-title":"Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-\u03baB activation through interaction with TAK1 and IKK complex","volume":"76","author":"Lan","year":"2020","journal-title":"Cell Signal."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib104","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib105","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3390\/life11111168","article-title":"PPAR\u03b1 modulation-based therapy in central nervous system diseases","volume":"11","author":"Lee","year":"2021","journal-title":"Life"},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib106","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.taap.2008.01.039","article-title":"Involvement of cyclin D1\/CDK4 and pRb mediated by PI3K\/AKT pathway activation in Pb2+ -induced neuronal death in cultured hippocampal neurons","volume":"229","author":"Li","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib107","article-title":"Research progress on the PEGylation of therapeutic proteins and peptides (TPPs)","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166260","article-title":"SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K\/AKT\/mTOR signaling","volume":"1867","author":"Li","year":"2021","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2025.102804_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115653","article-title":"Quercetin improves cerebral ischemia\/reperfusion injury by promoting microglia\/macrophages M2 polarization via regulating PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib110","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/jnr.24042","article-title":"Mitochondrial biogenesis in neurodegeneration","volume":"95","author":"Li","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"5-6","key":"10.1016\/j.arr.2025.102804_bib111","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/neu.2021.0382","article-title":"Restoration of brain angiotensin-converting enzyme 2 alleviates neurological deficits after severe traumatic brain injury via mitigation of pyroptosis and apoptosis","volume":"39","author":"Li","year":"2022","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.arr.2025.102804_bib112","article-title":"Targeting microglial \u03b1-Synuclein\/TLRs\/NF-kappaB\/NLRP3 inflammasome axis in Parkinson's disease","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2025.102804_bib113","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.731698","article-title":"Maternal high-fat diet alters the characteristics of astrocytes and worsens the outcome of stroke in rat offspring, which improves after FGF21 administration","volume":"9","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib114","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1007\/s12035-024-04063-1","article-title":"ACE2 rescues sepsis-associated encephalopathy by reducing inflammation, oxidative stress, and neuronal apoptosis via the Nrf2\/Sestrin2 signaling pathway","volume":"61","author":"Li","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"Pt A","key":"10.1016\/j.arr.2025.102804_bib115","article-title":"DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K\/AKT and ERK\/MAPK signaling through GRB2","volume":"142","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"15","key":"10.1016\/j.arr.2025.102804_bib116","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1080\/10408398.2020.1781049","article-title":"The ACE2\/Ang (1-7)\/MasR axis as an emerging target for antihypertensive peptides","volume":"61","author":"Liao","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib117","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/21623945.2021.1965315","article-title":"Resveratrol supplementation reduces ACE2 expression in human adipose tissue","volume":"10","author":"de Ligt","year":"2021","journal-title":"Adipocyte"},{"issue":"19","key":"10.1016\/j.arr.2025.102804_bib118","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122531119","article-title":"A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane","volume":"119","author":"Lin","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102804_bib119","article-title":"Research progress and strategy of FGF21 for skin wound healing","volume":"12","author":"Lin","year":"2025","journal-title":"Front. Med."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00501","article-title":"Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease","volume":"22","author":"Lin","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00501","article-title":"Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease","volume":"22","author":"Lin","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib122","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/md20040245","article-title":"Fucoxanthin prevents long-term administration l-DOPA-induced neurotoxicity through the ERK\/JNK-c-jun system in 6-OHDA-lesioned mice and PC12 cells","volume":"20","author":"Liu","year":"2022","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib123","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.arr.2025.102804_bib124","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroscience.2024.06.024","article-title":"The role of ACE2 in RAS axis on microglia activation in Parkinson's disease","volume":"553","author":"Liu","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2025.102804_bib125","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.2147\/JIR.S460161","article-title":"Role of inflammation in the development of COVID-19 to Parkinson's Disease","volume":"17","author":"Liu","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib126","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/pcmedi\/pbab014","article-title":"Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics","volume":"4","author":"Liu","year":"2021","journal-title":"Precis Clin. Med."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114173","article-title":"mTOR in metabolic homeostasis and disease","volume":"441","author":"Liu","year":"2024","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib128","doi-asserted-by":"crossref","first-page":"707","DOI":"10.32604\/biocell.2024.049130","article-title":"Pathogenic genes associated with parkinson\u2019s disease: molecular mechanism overview","volume":"48","author":"Liu","year":"2024","journal-title":"Biocell"},{"key":"10.1016\/j.arr.2025.102804_bib129","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.648636","article-title":"PI3K\/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease","volume":"12","author":"Long","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib130","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00011-022-01676-x","article-title":"Role of \u03b1-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease","volume":"72","author":"Lv","year":"2023","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib131","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11626-020-00493-y","article-title":"MiR-26b-5p regulates the preadipocyte differentiation by targeting FGF21 in goats","volume":"57","author":"Ma","year":"2021","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"key":"10.1016\/j.arr.2025.102804_bib132","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2193-1801-3-2","article-title":"Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1\u03b1 in human dopaminergic neurons via Sirtuin-1","volume":"3","author":"M\u00e4kel\u00e4","year":"2014","journal-title":"Springerplus"},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib133","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling pathway and cancer: an updated review","volume":"46","author":"Martini","year":"2014","journal-title":"Ann. Med."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib134","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/CS20130436","article-title":"Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling","volume":"126","author":"McKinney","year":"2014","journal-title":"Clin. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib135","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","article-title":"Lipid-based nanoparticles for drug\/gene delivery: an overview of the production techniques and difficulties encountered in their industrial development","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"key":"10.1016\/j.arr.2025.102804_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.109063","article-title":"Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy","volume":"713","author":"Meng","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib137","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.cell.2021.03.026","article-title":"BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection","volume":"184","author":"Mills","year":"2021","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib138","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1093\/cvr\/cvad070","article-title":"Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension","volume":"119","author":"Mohammed","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib139","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10787-023-01384-w","article-title":"Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK\/SIRT-1\/PGC-1\u03b1, and wnt\/\u03b2-catenin pathways","volume":"32","author":"Mohammed","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"13","key":"10.1016\/j.arr.2025.102804_bib140","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1080\/15384101.2023.2228089","article-title":"Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases","volume":"22","author":"Molaei","year":"2023","journal-title":"Cell Cycle"},{"issue":"13","key":"10.1016\/j.arr.2025.102804_bib141","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1080\/15384101.2023.2228089","article-title":"Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases","volume":"22","author":"Molaei","year":"2023","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib142","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.16214","article-title":"HSP110 is a modulator of amyloid beta (A\u03b2) aggregation and proteotoxicity","volume":"169","author":"Montresor","year":"2025","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib143","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s11064-023-03904-0","article-title":"Mitochondrial dysfunction and Parkinson's disease: pathogenesis and therapeutic strategies","volume":"48","author":"Moradi Vastegani","year":"2023","journal-title":"Neurochem. Res."},{"issue":"23","key":"10.1016\/j.arr.2025.102804_bib144","doi-asserted-by":"crossref","first-page":"12955","DOI":"10.3390\/ijms222312955","article-title":"Involvement of the ACE2\/Ang-(1-7)\/MasR axis in pulmonary fibrosis: implications for COVID-19","volume":"22","author":"Morganstein","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.17691\/stm2020.12.6.11","article-title":"Molecular Mechanisms of Proteins - Targets for SARS-CoV-2","volume":"12","author":"Morgun","year":"2021","journal-title":"Sovrem. Tekhnologii Med."},{"key":"10.1016\/j.arr.2025.102804_bib146","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog. Lipid Res."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib147","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1159\/000350108","article-title":"Crosstalk between PI3 kinase\/PDK1\/Akt\/Rac1 and Ras\/Raf\/MEK\/ERK pathways downstream PDGF receptor","volume":"31","author":"Niba","year":"2013","journal-title":"Cell Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib148","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/s44319-024-00149-y","article-title":"Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis","volume":"25","author":"Nikolic","year":"2024","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib149","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2024.01.042","article-title":"Past, present, and future of CRISPR genome editing technologies","volume":"187","author":"Pacesa","year":"2024","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib150","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13046-022-02416-z","article-title":"Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary renal cell carcinoma","volume":"41","author":"Pahwa","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104879","article-title":"The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction","volume":"299","author":"Pajarillo","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102804_bib152","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2147\/JIR.S307801","article-title":"The ACE2-Ang-(1-7)-mas axis modulates M1\/M2 macrophage polarization to relieve CLP-induced inflammation via TLR4-mediated NF-\u043ab and MAPK pathways","volume":"14","author":"Pan","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib153","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cmet.2018.04.002","article-title":"FGF21 prevents Angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2\/Angiotensin-(1-7) axis in mice","volume":"27","author":"Pan","year":"2018","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib154","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/biomedicines10030714","article-title":"Periodontal disease augments cardiovascular disease risk biomarkers in rheumatoid arthritis","volume":"10","author":"Panezai","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib155","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11064-021-03469-w","article-title":"ACE2 rescues impaired autophagic flux through the PI3K\/AKT pathway after subarachnoid hemorrhage","volume":"47","author":"Pang","year":"2022","journal-title":"Neurochem. Res"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib156","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12929-023-00961-z","article-title":"Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1\/MAPK\/AMPK\/mTOR signaling pathways","volume":"30","author":"Park","year":"2023","journal-title":"J. Biomed. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib157","article-title":"New targets for NAFLD","volume":"3","author":"Parlati","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.arr.2025.102804_bib158","article-title":"PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway?","volume":"12","author":"Peng","year":"2022","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib159","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/ijms21051769","article-title":"EPA is more effective than DHA to improve depression-like behavior, glia cell dysfunction and hippcampal apoptosis signaling in a chronic stress-induced rat model of depression","volume":"21","author":"Peng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.arr.2025.102804_bib160","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/antiox9080647","article-title":"Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration","volume":"9","author":"Picca","year":"2020","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib161","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/jcm9020504","article-title":"Mitochondrial signatures in circulating extracellular vesicles of older adults with Parkinson's disease: results from the exosomes in parkinson's disease (EXPAND) study","volume":"9","author":"Picca","year":"2020","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib162","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: one century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib163","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12035-019-01708-4","article-title":"11\u03b2-HSD1 inhibition rescues SAMP8 cognitive impairment induced by metabolic stress","volume":"57","author":"Puigoriol-Illamola","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib164","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13041-017-0340-9","article-title":"Oxidative stress and cellular pathologies in Parkinson's disease","volume":"10","author":"Puspita","year":"2017","journal-title":"Mol. Brain"},{"issue":"Pt1","key":"10.1016\/j.arr.2025.102804_bib165","article-title":"Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy","volume":"273","author":"Qi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib166","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jcmgh.2022.07.012","article-title":"Hepatocyte-secreted autotaxin exacerbates nonalcoholic fatty liver disease through autocrine inhibition of the PPAR\u03b1\/FGF21 axis","volume":"14","author":"Qiu","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib167","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1167\/iovs.14-13883","article-title":"Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice","volume":"55","author":"Qiu","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.arr.2025.102804_bib168","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for cancer therapy: challenges and future perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib169","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s13311-020-00986-4","article-title":"Novel interactions involving the mas receptor show potential of the renin-angiotensin system in the regulation of microglia activation: altered expression in parkinsonism and dyskinesia","volume":"18","author":"Rivas-Santisteban","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib170","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.18632\/aging.101086","article-title":"Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK\/mTOR pathway","volume":"8","author":"R\u00fchlmann","year":"2016","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib171","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3233\/JAD-200837","article-title":"Neuroprotective effects of the FGF21 analogue LY2405319","volume":"80","author":"R\u00fchlmann","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib172","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.plipres.2010.05.004","article-title":"Alpha-synuclein, lipids and Parkinson's disease","volume":"49","author":"Ruip\u00e9rez","year":"2010","journal-title":"Prog. Lipid Res."},{"issue":"16","key":"10.1016\/j.arr.2025.102804_bib173","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.3390\/nu15163585","article-title":"The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis","author":"Ruiz-Pozo","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib174","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00109-016-1477-1","article-title":"FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process","volume":"95","author":"Salminen","year":"2017","journal-title":"J. Mol. Med."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib175","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1210\/en.2015-1722","article-title":"Overexpression of \u03b2-Klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity","volume":"157","author":"Samms","year":"2016","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib176","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/Angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib177","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1172\/JCI69608","article-title":"Apelin is a positive regulator of ACE2 in failing hearts","volume":"123","author":"Sato","year":"2013","journal-title":"J. Clin. Invest"},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib178","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3390\/md17070407","article-title":"Ishige okamurae extract ameliorates the hyperglycemia and body weight gain of db\/db mice through regulation of the PI3K\/Akt pathway and thermogenic factors by FGF21","volume":"17","author":"Seo","year":"2019","journal-title":"Mar. Drugs"},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib179","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.3390\/nu15071713","article-title":"Reduction of plasma BCAAs following Roux-en-Y gastric bypass surgery is primarily mediated by FGF21","volume":"15","author":"Shah","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib180","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41531-024-00791-2","article-title":"MicroRNAs regulation in Parkinson's disease, and their potential role as diagnostic and therapeutic targets","volume":"10","author":"Shaheen","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib181","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11154-021-09652-2","article-title":"AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance","volume":"22","author":"Sharma","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"15","key":"10.1016\/j.arr.2025.102804_bib182","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.neuron.2023.05.006","article-title":"An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology","volume":"111","author":"Sheehan","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102804_bib183","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3389\/fphys.2020.01067","article-title":"Role of renin-angiotensin system components in atherosclerosis: focus on Ang-II, ACE2, and Ang-1-7","volume":"11","author":"Silva","year":"2020","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.arr.2025.102804_bib184","doi-asserted-by":"crossref","first-page":"H1697","DOI":"10.1152\/ajpheart.00854.2014","article-title":"ACE2\/Ang-(1-7)\/Mas axis stimulates vascular repair-relevant functions of CD34+ cells","volume":"309","author":"Singh","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.arr.2025.102804_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105743","article-title":"Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1\/2 and NF-kB pathway","volume":"75","author":"Somensi","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib186","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s11684-019-0724-6","article-title":"Biological properties and clinical applications of berberine","volume":"14","author":"Song","year":"2020","journal-title":"Front. Med."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib187","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10735-021-10011-3","article-title":"Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling","volume":"52","author":"Song","year":"2021","journal-title":"J. Mol. Histol."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib188","doi-asserted-by":"crossref","first-page":"16291","DOI":"10.1096\/fj.202001639R","article-title":"Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism","volume":"34","author":"Song","year":"2020","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109128","article-title":"Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms","volume":"35","author":"Sostre-Col\u00f3n","year":"2021","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib190","doi-asserted-by":"crossref","first-page":"H1084","DOI":"10.1152\/ajpheart.00217.2020","article-title":"COVID-19, ACE2, and the cardiovascular consequences","volume":"318","author":"South","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib191","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/bcp.15016","article-title":"Drug tolerability: how much ambiguity can be tolerated? A systematic review of the assessment of tolerability in clinical studies","volume":"88","author":"Stanulovi\u0107","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"s1","key":"10.1016\/j.arr.2025.102804_bib192","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.3233\/JPD-223237","article-title":"Microglia in Parkinson's disease","volume":"12","author":"Stefanova","year":"2022","journal-title":"J. Parkinsons Dis."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib193","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/genes11070741","article-title":"Analysis of ACE2 genetic variability among populations highlights a possible link with COVID-19-related neurological complications","volume":"11","author":"Strafella","year":"2020","journal-title":"Genes"},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib194","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joca.2020.02.027","article-title":"The PI3K\/AKT\/mTOR signaling pathway in osteoarthritis: a narrative review","volume":"28","author":"Sun","year":"2020","journal-title":"Osteoarthr. Cartil."},{"issue":"18","key":"10.1016\/j.arr.2025.102804_bib195","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.7150\/thno.44370","article-title":"Modulation of the astrocyte-neuron lactate shuttle system contributes to neuroprotective action of fibroblast growth factor 21","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2025.102804_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102690","article-title":"Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease","volume":"62","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib197","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cmet.2016.02.001","article-title":"A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and Type 2 diabetic subjects","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.arr.2025.102804_bib198","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/polym14091672","article-title":"PH responsive polyurethane for the advancement of biomedical and drug delivery","volume":"14","author":"Tan","year":"2022","journal-title":"Polymers"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib199","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential roles of M1 and M2 microglia in neurodegenerative Diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib200","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cmet.2020.05.001","article-title":"GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function","volume":"31","author":"Timper","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib201","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tips.2023.11.004","article-title":"PPAR agonists for the treatment of neuroinflammatory diseases","volume":"45","author":"Titus","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib202","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s12640-022-00540-4","article-title":"COVID-19 and Parkinson's disease: possible links in pathology and therapeutics","volume":"40","author":"Tiwari","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2025.102804_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175623","article-title":"ACE2\/ANG-(1-7)\/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes","volume":"946","author":"Tiwari","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib204","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00018-022-04240-2","article-title":"Initiation and progression of \u03b1-synuclein pathology in Parkinson's disease","volume":"79","author":"Tofaris","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102804_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108063","article-title":"Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain","volume":"178","author":"Tong","year":"2023","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib206","first-page":"439","article-title":"Non-invasive strategies for nose-to-brain drug delivery","volume":"10","author":"Trevino","year":"2020","journal-title":"J. Clin. Trials"},{"key":"10.1016\/j.arr.2025.102804_bib207","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/B978-0-12-801364-9.00025-0","article-title":"ACE2 cell biology, regulation, and physiological functions","author":"Turner","year":"2015","journal-title":"Prot. Arm. Renin Angiotensin Syst. (RAS)"},{"key":"10.1016\/j.arr.2025.102804_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104778","article-title":"Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease","volume":"95","author":"Vaikunthanathan","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2025.102804_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102078","article-title":"An ACE2\/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria","volume":"46","author":"Valenzuela","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib210","first-page":"12037","article-title":"Angiotensin-(1-7) improves skeletal muscle regeneration","volume":"33","author":"Valero-Breton","year":"2023","journal-title":"Eur. J. Transl. Myol."},{"issue":"23","key":"10.1016\/j.arr.2025.102804_bib211","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1042\/CS20200478","article-title":"ACE2 in the renin-angiotensin system","volume":"134","author":"Verano-Braga","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.arr.2025.102804_bib212","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcdb.2021.10.012","article-title":"Overview of the regulation of the class IA PI3K\/AKT pathway by SUMO","volume":"132","author":"Vidal","year":"2022","journal-title":"Semin Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib213","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/biof.1300","article-title":"Upregulation of rat liver PPAR\u03b1-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol","volume":"42","author":"Videla","year":"2016","journal-title":"Biofactors"},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib214","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11745-014-3948-x","article-title":"Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids","volume":"49","author":"Villarroya","year":"2014","journal-title":"Lipids"},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib215","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201810248","article-title":"Inflammasomes in neuroinflammatory and neurodegenerative diseases","volume":"11","author":"Voet","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.arr.2025.102804_bib216","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40035-016-0065-1","article-title":"Dysregulation of autophagy and mitochondrial function in Parkinson's disease","volume":"5","author":"Wang","year":"2016","journal-title":"Transl. Neurodegener."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib217","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib218","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12974-020-01921-2","article-title":"FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia\/macrophages","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2025.102804_bib219","article-title":"FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"19","key":"10.1016\/j.arr.2025.102804_bib220","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400125","article-title":"BV2 membrane-coated PEGylated-liposomes delivered hFGF21 to cortical and hippocampal microglia for Alzheimer's disease therapy","volume":"13","author":"Wang","year":"2024","journal-title":"Adv. Health Mater."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib221","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.apsb.2021.07.023","article-title":"Targeting PI3K\/AKT signaling for treatment of idiopathic pulmonary fibrosis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib222","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11064-025-04350-w","article-title":"Improvements in exercise for Alzheimer's disease: highlighting FGF21-induced cerebrovascular protection","volume":"50","author":"Wang","year":"2025","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib223","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","article-title":"Adeno-associated virus as a delivery vector for gene therapy of human diseases","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib224","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/FJC.0000000000001372","article-title":"HDAC inhibitors alleviate uric acid-induced vascular endothelial cell injury by way of the HDAC6\/FGF21\/PI3K\/AKT pathway","volume":"81","author":"Wang","year":"2023","journal-title":"J. Cardiovasc Pharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib225","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.freeradbiomed.2024.02.023","article-title":"Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K\/AKT\/mTOR and MAPK-mediated neuroinflammation","volume":"216","author":"Wang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"11-12","key":"10.1016\/j.arr.2025.102804_bib226","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00424-016-1875-9","article-title":"Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating KCa3.1 channel via ERK1\/2 pathway","volume":"468","author":"Wang","year":"2016","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.arr.2025.102804_bib227","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib228","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.bbrc.2017.06.064","article-title":"FGF21 regulates melanogenesis in alpaca melanocytes via ERK1\/2-mediated MITF downregulation","volume":"490","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res Commun."},{"key":"10.1016\/j.arr.2025.102804_bib229","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.2147\/DDDT.S194787","article-title":"Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K\/AKT\/mTOR, Bcl-2\/Bax and caspase-3\/cleaved caspase-3 signaling pathways","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.arr.2025.102804_bib230","article-title":"Feedback activation of basic fibroblast growth factor signaling via the Wnt\/\u03b2-catenin pathway in skin fibroblasts","author":"Wang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib231","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fphar.2020.00154","article-title":"FGF21 attenuated lps-induced depressive-like behavior via inhibiting the inflammatory pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib232","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s40265-024-02015-6","article-title":"Comparative efficacy of drug interventions on NAFLD over 24 weeks: a traditional and network meta-analysis of randomized controlled trials","volume":"84","author":"Wang","year":"2024","journal-title":"Drugs"},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib233","doi-asserted-by":"crossref","first-page":"351","DOI":"10.31083\/j.fbl2812351","article-title":"FGF21: a sharp weapon in the process of exercise to improve NAFLD","volume":"28","author":"Wang","year":"2023","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib234","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"\u03b1-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2025.102804_bib235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib236","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"16","key":"10.1016\/j.arr.2025.102804_bib237","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1111\/bph.15099","article-title":"Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21\/PGC-1\u03b1 pathway","volume":"177","author":"Wu","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"Pt3","key":"10.1016\/j.arr.2025.102804_bib238","article-title":"Cimicifuga heracleifolia kom. Attenuates ulcerative colitis through the PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"337","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib239","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/s41401-021-00786-2","article-title":"Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21\/FGFR1 signaling pathway","volume":"43","author":"Wu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib240","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s10565-024-09923-z","article-title":"ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-\u03baB\/STAT1 signals","volume":"40","author":"Xiao","year":"2024","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib241","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/eji.201444823","article-title":"Cerebral regulatory T cells restrain microglia\/macrophage-mediated inflammatory responses via IL-10","volume":"45","author":"Xie","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib242","doi-asserted-by":"crossref","first-page":"R804","DOI":"10.1152\/ajpregu.00222.2010","article-title":"ACE2\/ANG-(1-7)\/Mas pathway in the brain: the axis of good","volume":"300","author":"Xu","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib243","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3390\/ijms17122001","article-title":"The role of ERK1\/2 in the development of diabetic cardiomyopathy","volume":"17","author":"Xu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib244","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1007\/s12035-024-04673-9","article-title":"FGF21 exhibits neuroprotective effects by promoting 5-HT1AR-FGFR1 heteroreceptor complexes and triggering MEK1\/2-ERK1\/2 signaling pathway","volume":"62","author":"Yan","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102804_bib245","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.778527","article-title":"Fibroblast growth factor 21 modulates microglial polarization that attenuates neurodegeneration in mice and cellular models of Parkinson's disease","volume":"13","author":"Yang","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib246","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/ars.2016.6950","article-title":"ACE2 and the homolog collectrin in the modulation of nitric oxide and oxidative stress in blood pressure homeostasis and vascular injury","volume":"26","author":"Yang","year":"2017","journal-title":"Antioxid. Redox Signal"},{"issue":"12","key":"10.1016\/j.arr.2025.102804_bib247","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166558","article-title":"FGF21 at physiological concentrations regulates vascular endothelial cell function through multiple pathways","volume":"1868","author":"Yang","year":"2022","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"1-2","key":"10.1016\/j.arr.2025.102804_bib248","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and diseases: role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.arr.2025.102804_bib249","article-title":"Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2\/HO-1\/GPX4 activation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib250","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jcmm.17144","article-title":"FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway","volume":"26","author":"Yang","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib251","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1747-0285.2012.01325.x","article-title":"Understanding the physical interactions in the FGF21\/FGFR\/\u03b2-Klotho complex: structural requirements and implications in FGF21 signaling","volume":"79","author":"Yie","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.arr.2025.102804_bib252","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154798","article-title":"Fenofibrate, a PPAR\u03b1 agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy","volume":"120","author":"Yoo","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.arr.2025.102804_bib253","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117628","article-title":"Piperine promotes PI3K\/AKT\/mTOR-mediated gut-brain autophagy to degrade \u03b1-Synuclein in Parkinson's disease rats","volume":"322","author":"Yu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib254","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118875","article-title":"FGF21 promotes non-small cell lung cancer progression by SIRT1\/PI3K\/AKT signaling","volume":"269","author":"Yu","year":"2021","journal-title":"Life Sci."},{"issue":"1-2","key":"10.1016\/j.arr.2025.102804_bib255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11010-015-2358-6","article-title":"Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K\/Akt pathways","volume":"403","author":"Yu","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.arr.2025.102804_bib256","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.intimp.2016.05.026","article-title":"Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-\u03baB signaling pathway","volume":"38","author":"Yu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2025.102804_bib257","first-page":"353","article-title":"B. Mechanism and applications of CRISPR\/Cas-9-mediated genome editing","volume":"15","author":"Zawdie","year":"2021","journal-title":"Biologics"},{"key":"10.1016\/j.arr.2025.102804_bib258","doi-asserted-by":"crossref","DOI":"10.5603\/fm.103208","article-title":"METTL14 knockdown attenuates neuron injury and improves function recovery after spinal cord injury via regulating FGF21 in a m6A-IGF2BP1 dependent mechanism","author":"Zhang","year":"2025","journal-title":"Folia Morphol."},{"issue":"51","key":"10.1016\/j.arr.2025.102804_bib259","doi-asserted-by":"crossref","first-page":"35375","DOI":"10.1074\/jbc.M806480200","article-title":"S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib260","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/s41467-025-56885-9","article-title":"FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib261","doi-asserted-by":"crossref","first-page":"614","DOI":"10.7150\/thno.47007","article-title":"Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR\/Cas9 genome editing","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib262","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S1665-2681(19)31294-3","article-title":"Pioglitazone upregulates hepatic angiotensin converting enzyme 2 expression in rats with steatohepatitis","volume":"12","author":"Zhang","year":"2013","journal-title":"Ann. Hepatol."},{"issue":"11","key":"10.1016\/j.arr.2025.102804_bib263","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.bbamcr.2011.03.010","article-title":"Akt, FoxO and regulation of apoptosis","volume":"1813","author":"Zhang","year":"2011","journal-title":"Biochim Biophys. Acta"},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib264","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/jcp.29942","article-title":"FGF21 impedes peripheral myelin development by stimulating p38 MAPK\/c-Jun axis","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib265","doi-asserted-by":"crossref","first-page":"769","DOI":"10.31083\/j.rcm2203083","article-title":"Role of the ACE2\/Ang-(1-7)\/Mas axis in glucose metabolism","volume":"22","author":"Zhao","year":"2021","journal-title":"Rev. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.arr.2025.102804_bib266","first-page":"2354","article-title":"Neuroprotective effect of fasudil on inflammation through PI3K\/Akt and Wnt\/\u03b2-catenin dependent pathways in a mice model of Parkinson's disease","volume":"8","author":"Zhao","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.arr.2025.102804_bib267","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s40168-024-01872-3","article-title":"BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21","volume":"12","author":"Zheng","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.arr.2025.102804_bib268","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2014.04.060","article-title":"Activation of the ACE2\/Ang-(1-7)\/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction","volume":"273","author":"Zheng","year":"2014","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.arr.2025.102804_bib269","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/cns.13123","article-title":"Astrocyte morphology: diversity, plasticity, and role in neurological diseases","volume":"25","author":"Zhou","year":"2019","journal-title":"CNS Neurosci. Ther."},{"issue":"2","key":"10.1016\/j.arr.2025.102804_bib270","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.bbrc.2017.12.070","article-title":"Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77","volume":"495","author":"Zhou","year":"2018","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2025.102804_bib271","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102877","article-title":"FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue","volume":"67","author":"Zhou","year":"2023","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.arr.2025.102804_bib272","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1016\/S2666-7568(24)00094-1","article-title":"Temporal trends in the prevalence of Parkinson's disease from 1980 to 2023: a systematic review and meta-analysis","volume":"5","author":"Zhu","year":"2024","journal-title":"Lancet Healthy Longev."},{"issue":"5","key":"10.1016\/j.arr.2025.102804_bib273","doi-asserted-by":"crossref","first-page":"H827","DOI":"10.1152\/ajpheart.00814.2014","article-title":"Activation of angiotensin II type 2 receptor suppresses TNF-\u03b1-induced ICAM-1 via NF-\u043aB: possible role of ACE2","volume":"309","author":"Zhu","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.arr.2025.102804_bib274","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.576745","article-title":"Arga\u00f1araz ER. ACE2\/ADAM17\/TMPRSS2 interplay may be the main risk factor for COVID-19","volume":"11","author":"Zipeto","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.arr.2025.102804_bib275","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s44321-024-00036-y","article-title":"Promoting expression in gene therapy: more is not always better","volume":"16","author":"Zwartkruis","year":"2024","journal-title":"EMBO Mol. Med."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:29:42Z","timestamp":1788949782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725001503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":275,"alternative-id":["S1568163725001503"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102804","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic pathways in Parkinson's disease: The promise of FGF21 and ACE2","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102804"}}