{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:51:58Z","timestamp":1792414318172,"version":"4.4.0"},"reference-count":335,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005685","name":"The University of Alabama at Birmingham Department of Genetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005685","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011531","name":"University of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019921","name":"National Scleroderma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.arr.2025.102812","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T12:01:52Z","timestamp":1750680112000},"page":"102812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Crosstalk between oxidative stress, mitochondrial dysfunction, chromosome instability, and the activation of the cGAS-STING\/IFN pathway in systemic sclerosis"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-0137","authenticated-orcid":false,"given":"Mohammad","family":"Waseem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azait","family":"Imtiaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-3359","authenticated-orcid":false,"given":"Rafael","family":"Contreras-Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/1381612826666200107144810","article-title":"Emerging role of mitophagy in inflammatory diseases: cellular and molecular episodes","volume":"26","author":"A A MA","year":"2020","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2019.02.038","article-title":"Interleukin-1\u03b2 Induces mtDNA Release to activate innate immune signaling via cGAS-STING","volume":"74","author":"Aarreberg","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102812_bib3","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3389\/fphys.2018.01177","article-title":"The role of oxidative stress in the development of systemic sclerosis related vasculopathy","volume":"9","author":"Abdulle","year":"2018","journal-title":"Front Physiol."},{"issue":"6431","key":"10.1016\/j.arr.2025.102812_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8657","article-title":"cGAS in action: expanding roles in immunity and inflammation","volume":"363","author":"Ablasser","year":"2019","journal-title":"Science"},{"issue":"7454","key":"10.1016\/j.arr.2025.102812_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2\u2032-5\u2032-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib6","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.4049\/jimmunol.1400737","article-title":"TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner","volume":"192","author":"Ablasser","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101252","article-title":"Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis","volume":"96","author":"Abraham","year":"2024","journal-title":"Mol. Asp. Med"},{"issue":"423","key":"10.1016\/j.arr.2025.102812_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam8458","article-title":"Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8","volume":"10","author":"Ah Kioon","year":"2018","journal-title":"Sci. Transl. Med"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/rheumatology\/keac410","article-title":"Macrophages as determinants and regulators of fibrosis in systemic sclerosis","volume":"62","author":"Al-Adwi","year":"2023","journal-title":"Rheumatol. (Oxf. )"},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib10","first-page":"1787","article-title":"Immune-mediated skin diseases: future therapeutic perspectives","volume":"59","author":"Alaibac","year":"2023","journal-title":"Med. (Kaunas. )"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cellimm.2007.06.007","article-title":"Immunogenicity of mitochondrial DNA modified by hydroxyl radical","volume":"247","author":"Alam","year":"2007","journal-title":"Cell Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/genes5010033","article-title":"The past, present, and future of human centromere genomics","volume":"5","author":"Aldrup-Macdonald","year":"2014","journal-title":"Genes"},{"key":"10.1016\/j.arr.2025.102812_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14392","article-title":"IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes","volume":"8","author":"Almine","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102812_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.767219","article-title":"Mitochondrial extracellular vesicles - origins and roles","volume":"14","author":"Amari","year":"2021","journal-title":"Front Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/art.40002","article-title":"Expression of cyclic GMP-AMP synthase in patients with systemic lupus erythematosus","volume":"69","author":"An","year":"2017","journal-title":"Arthritis Rheuma"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib16","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","article-title":"Oxidative cell death in cancer: mechanisms and therapeutic opportunities","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"issue":"23","key":"10.1016\/j.arr.2025.102812_bib17","doi-asserted-by":"crossref","first-page":"15182","DOI":"10.3390\/ijms232315182","article-title":"The relationship between reactive oxygen species and the cGAS\/STING signaling pathway in the inflammaging process","volume":"23","author":"Andrade","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.arr.2025.102812_bib18","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.arr.2025.102812_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/OARRR.S50009","article-title":"Animal models of systemic sclerosis: their utility and limitations","volume":"6","author":"Artlett","year":"2014","journal-title":"Open Access Rheuma"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13075-017-1331-z","article-title":"Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis","volume":"19","author":"Artlett","year":"2017","journal-title":"Arthritis Res Ther."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib21","article-title":"Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway","volume":"2","author":"Au-Yeung","year":"2013","journal-title":"JAKSTAT"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/BOR.0b013e32834ff2e8","article-title":"Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers","volume":"24","author":"Barnes","year":"2012","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/721608","article-title":"The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis","volume":"2011","author":"Barnes","year":"2011","journal-title":"Int J. Rheuma"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/BOR.0000000000000659","article-title":"Role of type I interferons and innate immunity in systemic sclerosis: unbalanced activities on distinct cell types?","volume":"31","author":"Barrat","year":"2019","journal-title":"Curr. Opin. Rheuma"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102867","article-title":"Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sj\u00f6gren's syndrome","volume":"20","author":"Barrera","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib26","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1038\/s41598-019-40900-3","article-title":"Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations","volume":"9","author":"Becker","year":"2019","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib27","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41584-022-00834-z","article-title":"The role of mitochondria in rheumatic diseases","volume":"18","author":"Becker","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109723","article-title":"Effects of Ruxolitinib on fibrosis in preclinical models of systemic sclerosis","volume":"116","author":"Bellamri","year":"2023","journal-title":"Int Immunopharmacol."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib29","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/nm.2861","article-title":"Ultraviolet radiation damages self noncoding RNA and is detected by TLR3","volume":"18","author":"Bernard","year":"2012","journal-title":"Nat. Med"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/mutage\/14.2.227","article-title":"R. Cytogenetic study and FISH analysis in lymphocytes of systemic lupus erythematosus (SLE) and systemic sclerosis (SS) patients","volume":"14","author":"Bevilacqua","year":"1999","journal-title":"Mutagenesis"},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib31","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/art.41243","article-title":"Profibrotic activation of human macrophages in systemic sclerosis","volume":"72","author":"Bhandari","year":"2020","journal-title":"Arthritis Rheuma"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/BOR.0000000000000967","article-title":"Animal models in systemic sclerosis: an update","volume":"35","author":"Bi","year":"2023","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1313426","article-title":"Mitochondrial DNA copy number in patients with systemic sclerosis","volume":"10","author":"Bogatyreva","year":"2023","journal-title":"Front Mol. Biosci."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/BOR.0b013e32834b0dac","article-title":"An update on an immune system that goes awry in systemic sclerosis","volume":"23","author":"van Bon","year":"2011","journal-title":"Curr. Opin. Rheuma"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJMoa1114576","article-title":"Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis","volume":"370","author":"van Bon","year":"2014","journal-title":"N. Engl. J. Med"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib36","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/annrheumdis-2015-207392","article-title":"The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis","volume":"75","author":"Brkic","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/cei.13238","article-title":"The immunopathogenesis of fibrosis in systemic sclerosis","volume":"195","author":"Brown","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.372","article-title":"Assessing mitochondrial DNA release into the cytosol and subsequent activation of innate immune-related pathways in mammalian cells","volume":"2","author":"Bryant","year":"2022","journal-title":"Curr. Protoc."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib39","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/art.43029","article-title":"Systemic sclerosis dermal fibroblast exosomes trigger type 1 interferon responses in keratinocytes via a TBK\/JAK\/STAT signaling axis","volume":"77","author":"Bryon","year":"2025","journal-title":"Arthritis Rheuma"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11926-020-00920-9","article-title":"Mitochondria, aging, and cellular senescence: implications for scleroderma","volume":"22","author":"Bueno","year":"2020","journal-title":"Curr. Rheuma Rep."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/cei\/uxac055","article-title":"Increased TNF-\u03b1 production in response to IL-6 in patients with systemic inflammation without infection","volume":"209","author":"Cabrera-Rivera","year":"2022","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/annrheumdis-2011-200275","article-title":"Spanish scleroderma group. novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis","volume":"71","author":"Carmona","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aag3358","article-title":"Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis","volume":"2","author":"Carmona-Rivera","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fimmu.2017.00345","article-title":"Dysregulated IL-1\u03b2 secretion in autoinflammatory diseases: a matter of stress?","volume":"8","author":"Carta","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114316","article-title":"Detection of viral infections by innate immunity","volume":"183","author":"Carty","year":"2021","journal-title":"Biochem Pharm."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/cei.13417","article-title":"Novel insights into dendritic cells in the pathogenesis of systemic sclerosis","volume":"201","author":"Carvalheiro","year":"2020","journal-title":"Clin. Exp. Immunol."},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib47","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3899\/jrheum.110167","article-title":"Primary biliary cirrhosis-related autoantibodies in a large cohort of italian patients with systemic sclerosis","volume":"38","author":"Cavazzana","year":"2011","journal-title":"J. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2017.10.001","article-title":"Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis","volume":"452","author":"Ceribelli","year":"2018","journal-title":"J. Immunol. Methods"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib49","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbabio.2008.10.007","article-title":"DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations","volume":"1787","author":"Chan","year":"2009","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.arr.2025.102812_bib50","article-title":"Research and progress of cGAS\/STING\/NLRP3 signaling pathway: a mini review","volume":"16","author":"Chen","year":"2025","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib51","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib52","article-title":"Mitochondrial control of innate immune responses","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.arr.2025.102812_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1149869","article-title":"Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis","volume":"14","author":"Ch\u00eane","year":"2023","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib55","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/BOR.0000000000000218","article-title":"Update on macrophages and innate immunity in scleroderma","volume":"27","author":"Chia","year":"2015","journal-title":"Curr. Opin. Rheuma"},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib56","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/jcph.2054","article-title":"Relationship between anifrolumab pharmacokinetics, pharmacodynamics, and efficacy in patients with moderate to severe systemic lupus erythematosus","volume":"62","author":"Chia","year":"2022","journal-title":"J. Clin. Pharm."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0961203318815768","article-title":"Sexual dimorphism in SLE: above and beyond sex hormones","volume":"28","author":"Christou","year":"2019","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib58","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","article-title":"Neutrophil extracellular traps promote differentiation and function of fibroblasts","volume":"233","author":"Chrysanthopoulou","year":"2014","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib59","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1164\/rccm.201708-1593ED","article-title":"Circulating mitochondrial DNA as a mechanism-based, prognostic biomarker for idiopathic pulmonary fibrosis","volume":"196","author":"Cloonan","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.arr.2025.102812_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104047","article-title":"Monocytes are the main source of STING-mediated IFN-\u03b1 production","volume":"80","author":"Congy-Jolivet","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2025.102812_bib61","article-title":"Systemic lupus erythematosus with and without Anti-dsDNA antibodies: analysis from a large monocentric cohort","volume":"2015","author":"Conti","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.arr.2025.102812_bib62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.semcancer.2013.12.007","article-title":"The role of reactive oxygen species and metabolism on cancer cells and their microenvironment","volume":"25","author":"Costa","year":"2014","journal-title":"Semin Cancer Biol."},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib63","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1248\/bpb.b19-00083","article-title":"Amelioration of CIA by asarinin is associated to a downregulation of TLR9\/NF-\u03baB and regulation of Th1\/Th2\/treg expression","volume":"42","author":"Dai","year":"2019","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib64","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00018-015-2110-0","article-title":"The myofibroblast, a key cell in normal and pathological tissue repair","volume":"73","author":"Darby","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib65","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.3390\/cells10112898","article-title":"Molecular mechanisms of mtDNA-mediated inflammation","volume":"10","author":"De Gaetano","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/23971983231181727","article-title":"Alveolar epithelial-to-mesenchymal transition in scleroderma interstitial lung disease: technical challenges, available evidence and therapeutic perspectives","volume":"9","author":"De Lorenzis","year":"2024","journal-title":"J. Scleroderma Relat. Disord."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib67","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.str.2022.05.012","article-title":"Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential","volume":"30","author":"Dejmek","year":"2022","journal-title":"Structure"},{"key":"10.1016\/j.arr.2025.102812_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/art.43120","article-title":"Serum type I interferon score for prediction of clinically meaningful disease progression in limited cutaneous systemic sclerosis","author":"Di Donato","year":"2025","journal-title":"Arthritis Rheuma"},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib69","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.3390\/jcm9072136","article-title":"Neutrophil extracellular traps generation relates with early stage and vascular complications in systemic sclerosis","volume":"9","author":"Didier","year":"2020","journal-title":"J. Clin. Med"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib70","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/art.24183","article-title":"Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis","volume":"60","author":"Dieud\u00e9","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"7899","key":"10.1016\/j.arr.2025.102812_bib71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"Domizio","year":"2022","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib72","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41416-022-01876-6","article-title":"Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity","volume":"127","author":"Dongye","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.arr.2025.102812_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101122","article-title":"Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis","volume":"25","author":"Doridot","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2025.102812_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-like receptor signaling and its role in cell-mediated immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib75","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2018.07.034","article-title":"Non-canonical activation of the DNA sensing adaptor sting by ATM and IFI16 mediates NF-\u03baB signaling after nuclear DNA damage","volume":"71","author":"Dunphy","year":"2018","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib76","first-page":"81","article-title":"Chromosomal breakage and scleroderma: studies in family members","volume":"88","author":"Emerit","year":"1976","journal-title":"J. Lab Clin. Med"},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165845","article-title":"Mitochondrial function in immune cells in health and disease","volume":"1866","author":"Faas","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib78","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1038\/s41423-020-0456-1","article-title":"Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine","volume":"18","author":"Fang","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.651013","article-title":"Innate immune modulation induced by ebv lytic infection promotes endothelial cell inflammation and vascular injury in scleroderma","volume":"12","author":"Farina","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib80","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2147\/DDDT.S170969","article-title":"Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date","volume":"13","author":"Felten","year":"2019","journal-title":"Drug Des. Devel Ther."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib81","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/1873-3468.14021","article-title":"Mitochondrial DNA copy number in human disease: the more the better?","volume":"595","author":"Filograna","year":"2021","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib82","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2023.02.021","article-title":"Mitochondrial pores at the crossroad between cell death and inflammatory signaling","volume":"83","author":"Flores-Romero","year":"2023","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib83","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/cells9040915","article-title":"Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses","volume":"9","author":"Fousert","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2025.102812_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.621501","article-title":"The complexity of the cGAS-STING pathway in cns pathologies","volume":"15","author":"Fryer","year":"2021","journal-title":"Front Neurosci."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib85","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jaad.2023.02.061","article-title":"Interleukin-17 pathway inhibition with brodalumab in early systemic sclerosis: analysis of a single-arm, open-label, phase 1 trial","volume":"89","author":"Fukasawa","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.arr.2025.102812_bib86","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/ITT.S82037","article-title":"Current perspectives on the immunopathogenesis of systemic sclerosis","volume":"5","author":"Fuschiotti","year":"2016","journal-title":"Immunotargets Ther."},{"issue":"19","key":"10.1016\/j.arr.2025.102812_bib87","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N. Engl. J. Med"},{"issue":"42","key":"10.1016\/j.arr.2025.102812_bib88","doi-asserted-by":"crossref","first-page":"E5699","DOI":"10.1073\/pnas.1516465112","article-title":"Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases","volume":"112","author":"Gao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib89","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.cell.2013.04.046","article-title":"Cyclic [G(2\u2032,5\u2032)pA(3\u2032,5\u2032)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase","volume":"153","author":"Gao","year":"2013","journal-title":"Cell"},{"issue":"73","key":"10.1016\/j.arr.2025.102812_bib90","doi-asserted-by":"crossref","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci. Transl. Med"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib91","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.immuni.2013.08.004","article-title":"Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing","volume":"39","author":"Gehrke","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib92","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s40674-023-00211-1","article-title":"Mitochondrial DNA Sensing pathogen recognition receptors in systemic sclerosis associated interstitial lung disease: a review","volume":"9","author":"Ghincea","year":"2023","journal-title":"Curr. Treatm Opt. Rheuma"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib93","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s40674-023-00211-1","article-title":"Mitochondrial DNA Sensing pathogen recognition receptors in systemic sclerosis associated interstitial lung disease: a review","volume":"9","author":"Ghincea","year":"2023","journal-title":"Curr. Treatm Opt. Rheuma"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib94","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002010","article-title":"Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus","volume":"7","author":"Giaglis","year":"2021","journal-title":"RMD Open"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib95","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCRESAHA.120.316958","article-title":"Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation","volume":"127","author":"Gibb","year":"2020","journal-title":"Circ. Res"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib96","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41584-021-00606-1","article-title":"Interferon lambda in inflammation and autoimmune rheumatic diseases","volume":"17","author":"Goel","year":"2021","journal-title":"Nat. Rev. Rheuma"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib97","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1183\/09031936.00010910","article-title":"Increased epithelial permeability in pulmonary fibrosis in relation to disease progression","volume":"38","author":"Goh","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/ar4492","article-title":"Dose-escalation of human anti-interferon-\u03b1 receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study","volume":"16","author":"Goldberg","year":"2014","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.arr.2025.102812_bib99","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","article-title":"Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases","volume":"9","author":"Grazioli","year":"2018","journal-title":"Front Immunol."},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib100","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41419-022-05047-6","article-title":"A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol \u03b2 deficiency","volume":"13","author":"Gu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2025.102812_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112114","article-title":"Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway","volume":"133","author":"Gu","year":"2024","journal-title":"Int Immunopharmacol."},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib102","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrneph.2016.71","article-title":"The role of neutrophils and NETosis in autoimmune and renal diseases","volume":"12","author":"Gupta","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.arr.2025.102812_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107941","article-title":"The role of osteoprotegerin (OPG) in fibrosis: its potential as a biomarker and\/or biological target for the treatment of fibrotic diseases","volume":"228","author":"Habibie","year":"2021","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.arr.2025.102812_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112768","article-title":"The crosstalk between DNA-damage responses and innate immunity","volume":"140","author":"He","year":"2024","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib105","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41423-021-00673-0","article-title":"VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release","volume":"18","author":"He","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib106","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41423-021-00673-0","article-title":"VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release","volume":"18","author":"He","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib107","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib108","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BST20221525","article-title":"Mitochondrial DNA in cell death and inflammation","volume":"51","author":"Heilig","year":"2023","journal-title":"Biochem Soc. Trans."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib109","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BST20221525","article-title":"Mitochondrial DNA in cell death and inflammation","volume":"51","author":"Heilig","year":"2023","journal-title":"Biochem Soc. Trans."},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib110","doi-asserted-by":"crossref","first-page":"729","DOI":"10.15252\/emmm.201505925","article-title":"Endoplasmic reticulum stress enhances fibrosis through IRE1\u03b1-mediated degradation of miR-150 and XBP-1 splicing","volume":"8","author":"Heindryckx","year":"2016","journal-title":"EMBO Mol. Med"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib111","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1016\/S2665-9913(24)00403-X","article-title":"Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study","volume":"7","author":"Hinchcliff","year":"2025","journal-title":"Lancet Rheuma"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib112","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jbiomech.2009.09.020","article-title":"The myofibroblast: paradigm for a mechanically active cell","volume":"43","author":"Hinz","year":"2010","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib113","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/ar628","article-title":"The clinical relevance of autoantibodies in scleroderma","volume":"5","author":"Ho","year":"2003","journal-title":"Arthritis Res Ther."},{"issue":"24","key":"10.1016\/j.arr.2025.102812_bib114","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105465118","article-title":"STING inhibitors target the cyclic dinucleotide binding pocket","volume":"118","author":"Hong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41392-024-01767-7","article-title":"The two sides of chromosomal instability: drivers and brakes in cancer","volume":"9","author":"Hosea","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.arr.2025.102812_bib116","article-title":"JAK1\/2 Inhibitor baricitinib improves skin fibrosis and digital ulcers in systemic sclerosis","volume":"9","author":"Hou","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"19","key":"10.1016\/j.arr.2025.102812_bib117","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.3390\/cells11193174","article-title":"Mitochondrial VDAC1: a potential therapeutic target of inflammation-related diseases and clinical opportunities","volume":"11","author":"Hu","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib118","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell Mol. Immunol."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib119","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1515\/cclm-2013-0926","article-title":"The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis","volume":"52","author":"Hu","year":"2014","journal-title":"Clin. Chem. Lab Med"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103155","article-title":"Emerging role of the cGAS-STING signaling pathway in autoimmune diseases: biologic function, mechanisms and clinical prospection","volume":"21","author":"Hu","year":"2022","journal-title":"Autoimmun. Rev."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib122","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1517\/14728222.2010.501333","article-title":"Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses","volume":"14","author":"Huang","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib123","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/03009742.2016.1195872","article-title":"A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia","volume":"46","author":"Hughes","year":"2017","journal-title":"Scand. J. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib124","unstructured":"Inokuchi S., Mitoma H., Kawano S., Ayano M., Kimoto Y., Akahoshi M., Arinobu Y., Akashi K., Horiuchi T., Niiro H. Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus. (2025)."},{"issue":"7213","key":"10.1016\/j.arr.2025.102812_bib125","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41467-023-44541-z","article-title":"GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fc\u03b3 receptor region","volume":"15","author":"Ishikawa","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib127","first-page":"169","article-title":"Cytogenetic survey in systemic sclerosis: correlation of aneuploidy with the presence of anticentromere antibodies","volume":"63","author":"Jabs","year":"1993","journal-title":"Cytogenet Cell Genet"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib128","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41598-019-41933-4","article-title":"Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis","volume":"9","author":"Jaeger","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib129","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1074\/jbc.M112.431973","article-title":"Mitochondrial reactive oxygen species regulate transforming growth factor-\u03b2 signaling","volume":"288","author":"Jain","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102812_bib130","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-3-031-06573-6_7","article-title":"CENP-A: A Histone H3 variant with key roles in centromere architecture in healthy and diseased states","volume":"70","author":"Jeffery","year":"2022","journal-title":"Results Probl. Cell Differ."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib131","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13578-023-01188-z","article-title":"The crucial regulatory role of type I interferon in inflammatory diseases","volume":"13","author":"Ji","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.arr.2025.102812_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1160035","article-title":"Mitochondria in innate immunity signaling and its therapeutic implications in autoimmune diseases","volume":"14","author":"Jiao","year":"2023","journal-title":"Front Immunol."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib133","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98380","article-title":"pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis","volume":"3","author":"Kafaja","year":"2018","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib134","first-page":"517","article-title":"EMT and interstitial lung disease: a mysterious relationship","volume":"18","author":"Kage","year":"2012","journal-title":"Curr. Opin. Pulm. Med"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib135","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/BOR.0000000000000907","article-title":"Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit","volume":"34","author":"Kakkar","year":"2022","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib136","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev-pathol-011110-130312","article-title":"The pathogenesis of systemic sclerosis","volume":"6","author":"Katsumoto","year":"2011","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.arr.2025.102812_bib137","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3389\/fimmu.2018.01896","article-title":"The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma","volume":"9","author":"Kavian","year":"2018","journal-title":"Front Immunol."},{"issue":"10038","key":"10.1016\/j.arr.2025.102812_bib138","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/S0140-6736(16)00232-4","article-title":"Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial","volume":"387","author":"Khanna","year":"2016","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.arr.2025.102812_bib139","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159566","article-title":"Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial","volume":"7","author":"Khanna","year":"2022","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib140","first-page":"1635","article-title":"A randomised, parallel-group, double-blind, placebo-controlled phase 3 study to Determine the effectiveness of the type I interferon receptor antibody, Anifrolumab, In SYstemic sclerosis: DAISY study design and rationale","volume":"42","author":"Khanna","year":"2024","journal-title":"Clin. Exp. Rheuma"},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib141","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/art.23486","article-title":"Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis","volume":"58","author":"Kim","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"6472","key":"10.1016\/j.arr.2025.102812_bib142","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"issue":"6472","key":"10.1016\/j.arr.2025.102812_bib143","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib144","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.arr.2025.102812_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2020.108335","article-title":"Micronuclei, inflammation and auto-immune disease","volume":"786","author":"Kirsch-Volders","year":"2020","journal-title":"Mutat. Res Rev. Mutat. Res"},{"issue":"18","key":"10.1016\/j.arr.2025.102812_bib146","doi-asserted-by":"crossref","first-page":"14287","DOI":"10.3390\/ijms241814287","article-title":"The pathogenesis of systemic sclerosis: the origin of fibrosis and interlink with vasculopathy and autoimmunity","volume":"24","author":"Ko","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib147","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2013.09.049","article-title":"Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling","volume":"155","author":"Konno","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102812_bib148","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3389\/fimmu.2017.00873","article-title":"The role of interferons in inflammation and inflammasome activation","volume":"8","author":"Kopitar-Jerala","year":"2017","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib149","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13075-024-03379-6","article-title":"Elevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog","volume":"26","author":"Kortam","year":"2024","journal-title":"Arthritis Res Ther."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib150","article-title":"Franggiannis N. Transforming growth factor-\u03b2 in tissue fibrosis","volume":"217","year":"2020","journal-title":"J. Exp. Med"},{"issue":"5-6","key":"10.1016\/j.arr.2025.102812_bib151","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbabio.2006.02.007","article-title":"Properties of the permeability transition in VDAC1(-\/-) mitochondria","volume":"1757","author":"Krauskopf","year":"2006","journal-title":"Biochim Biophys. Acta"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib152","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/imr.12903","article-title":"AIM2 in health and disease: Inflammasome and beyond","volume":"297","author":"Kumari","year":"2020","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib153","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1038\/s41467-019-08620-4","article-title":"Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression","volume":"10","author":"Lama","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib154","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/s41467-019-09683-z","article-title":"CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-\u03b1 production in systemic sclerosis","volume":"10","author":"Lande","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib155","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/antib10020012","article-title":"New autoantibody specificities in systemic sclerosis and very early systemic sclerosis","volume":"10","author":"Lande","year":"2021","journal-title":"Antibodies"},{"key":"10.1016\/j.arr.2025.102812_bib156","first-page":"224","article-title":"\"Mitochondrial DNA is inherited in a maternal manner in humans","volume":"395","author":"Larsson","year":"1998","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib157","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ni1028","article-title":"TLR9 signals after translocating from the ER to CpG DNA in the lysosome","volume":"5","author":"Latz","year":"2004","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib158","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/art.23035","article-title":"Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus","volume":"56","author":"Lee","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib159","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13075-024-03329-2","article-title":"Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis","volume":"26","author":"Lehmann","year":"2024","journal-title":"Arthritis Res Ther."},{"issue":"14","key":"10.1016\/j.arr.2025.102812_bib160","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.cell.2023.05.039","article-title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","volume":"186","author":"Lei","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102812_bib161","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.molimm.2020.12.037","article-title":"DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells","volume":"131","author":"Li","year":"2021","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib162","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib163","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1615\/CritRevImmunol.2023050273","article-title":"TLR9 knockdown alleviates sepsis via disruption of MyD88\/NF-\u03baB pathway activation","volume":"44","author":"Li","year":"2024","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib164","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41420-020-00316-9","article-title":"Mitochondrial dysfunction in fibrotic diseases","volume":"6","author":"Li","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.arr.2025.102812_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113876","article-title":"The STING antagonist SN-011 ameliorates cisplatin induced acute kidney injury via suppression of STING\/NF-\u03baB-mediated inflammation","volume":"146","author":"Li","year":"2025","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib166","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41584-023-01044-x","article-title":"Systemic sclerosis interstitial lung disease: unmet needs and potential solutions","volume":"20","author":"Liakouli","year":"2024","journal-title":"Nat. Rev. Rheuma"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib167","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ni.3643","article-title":"A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases","volume":"18","author":"Liang","year":"2017","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119233","article-title":"The fate of damaged mitochondrial DNA in the cell","volume":"1869","author":"Liao","year":"2022","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib169","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s13238-015-0144-6","article-title":"Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death","volume":"6","author":"Liao","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.arr.2025.102812_bib170","article-title":"CpG methylation patterns of human mitochondrial DNA","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.arr.2025.102812_bib171","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111173","article-title":"Prohibitin 1 regulates mtDNA release and downstream inflammatory responses","volume":"41","author":"Liu","year":"2022","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib172","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12964-023-01466-w","article-title":"cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102812_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110945","article-title":"Development of small molecule inhibitors\/agonists targeting STING for disease","volume":"132","author":"Liu","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.arr.2025.102812_bib174","article-title":"Updated roles of cGAS-STING signaling in autoimmune diseases","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib175","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/kjm2.12769","article-title":"TLR9 regulates the autophagy-lysosome pathway to promote dendritic cell maturation and activation by activating the TRAF6-cGAS-STING pathway","volume":"39","author":"Liu","year":"2023","journal-title":"Kaohsiung J. Med Sci."},{"key":"10.1016\/j.arr.2025.102812_bib176","article-title":"The role of mitochondrial DNA copy number in autoimmune disease: a bidirectional two sample mendelian randomization study","volume":"15","author":"Liu","year":"2024","journal-title":"Front Immunol."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib177","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3899\/jrheum.2022-0827","article-title":"Type I interferons in autoimmunity: implications in clinical phenotypes and treatment response","volume":"50","author":"Londe","year":"2023","journal-title":"J. Rheuma"},{"key":"10.1016\/j.arr.2025.102812_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.973089","article-title":"Role of released mitochondrial DNA in acute lung injury","volume":"13","author":"Long","year":"2022","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib179","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib180","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib181","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med"},{"issue":"1 Pt 1","key":"10.1016\/j.arr.2025.102812_bib182","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2015.09.058","article-title":"The type I interferons: basic concepts and clinical relevance in immune-mediated inflammatory diseases","volume":"576","author":"L\u00f3pez de Padilla","year":"2016","journal-title":"Gene"},{"issue":"7906","key":"10.1016\/j.arr.2025.102812_bib183","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-022-04559-7","article-title":"Activation of STING by targeting a pocket in the transmembrane domain","volume":"604","author":"Lu","year":"2022","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib184","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011186","article-title":"Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1","volume":"19","author":"Lui","year":"2023","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib185","doi-asserted-by":"crossref","first-page":"13156","DOI":"10.1096\/fj.202001607R","article-title":"The cGAS-STING pathway: the role of self-DNA sensing in inflammatory lung disease","volume":"34","author":"Ma","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2025.102812_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112516","article-title":"Nets in fibrosis: bridging innate immunity and tissue remodeling","volume":"137","author":"Ma","year":"2024","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib187","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING Signaling In Acute Kidney Injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib188","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.mito.2012.10.011","article-title":"Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?","volume":"13","author":"Malik","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.arr.2025.102812_bib189","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fcimb.2013.00077","article-title":"Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection","volume":"3","author":"Malireddi","year":"2013","journal-title":"Front Cell Infect. Microbiol"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib190","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3109\/03009741003685640","article-title":"Increased chromosome damage in systemic sclerosis skin fibroblasts","volume":"39","author":"Martins","year":"2010","journal-title":"Scand. J. Rheuma"},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib191","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.3390\/ijms24097898","article-title":"Mechanisms of oxidative stress in metabolic syndrome","volume":"24","author":"Masenga","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib192","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.3390\/ijms24097898","article-title":"Mechanisms of oxidative stress in metabolic syndrome","volume":"24","author":"Masenga","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib193","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1517\/14728222.2015.1069275","article-title":"Therapeutic targeting of Toll-like receptors in cutaneous disorders","volume":"19","author":"Matin","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"issue":"6378","key":"10.1016\/j.arr.2025.102812_bib194","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102812_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00525","article-title":"Mitochondrial dysfunction in Alzheimer's disease: guiding the path to targeted therapies","author":"McGill Percy","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2025.102812_bib196","article-title":"Anti-mitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility","volume":"2024","author":"McMahan","year":"2024","journal-title":"medRxiv [Prepr. ]"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib197","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib198","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI23025","article-title":"Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9","volume":"115","author":"Means","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2025.102812_bib199","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.dnarep.2017.06.020","article-title":"DNA repair and systemic lupus erythematosus","volume":"56","author":"Meas","year":"2017","journal-title":"DNA Repair (Amst. )"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib200","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol Rev."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib201","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-47083-y","article-title":"Superiority of systemic bleomycin to intradermal HOCl for the study of interstitial lung disease","volume":"13","author":"Morozan","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib202","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.abd.2019.11.003","article-title":"Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay","volume":"95","author":"Movassaghi","year":"2020","journal-title":"Bras. Dermatol."},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib203","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/d41573-023-00185-8","article-title":"Biotechs step on cGAS for autoimmune diseases","volume":"22","author":"Mullard","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"17","key":"10.1016\/j.arr.2025.102812_bib204","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/ars.2015.6407","article-title":"The roles of mitochondrial damage-associated molecular patterns in diseases","volume":"23","author":"Nakahira","year":"2015","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.arr.2025.102812_bib205","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1433961","article-title":"Role of mitochondria in inflammatory lung diseases","volume":"15","author":"Narala","year":"2024","journal-title":"Front Pharm."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib206","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcad019","article-title":"Molecular mechanisms protecting centromeres from self-sabotage and implications for cancer therapy","volume":"5","author":"Nassar","year":"2023","journal-title":"NAR Cancer"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib207","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/ijms25063303","article-title":"Dermatologic manifestations of mitochondrial dysfunction: a review of the literature","volume":"25","author":"Natarelli","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102812_bib208","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-biochem-032620-104401","article-title":"Mitochondrial DNA release in innate immune signaling","volume":"92","author":"Newman","year":"2023","journal-title":"Annu Rev. Biochem"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib209","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.173.2.807","article-title":"B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells","volume":"173","author":"Ng","year":"2004","journal-title":"J. Immunol."},{"issue":"24","key":"10.1016\/j.arr.2025.102812_bib210","doi-asserted-by":"crossref","first-page":"17635","DOI":"10.3390\/ijms242417635","article-title":"ISGF3 and STAT2\/IRF9 control basal and IFN-induced transcription through genome-wide binding of phosphorylated and unphosphorylated complexes to common ISRE-containing ISGs","volume":"24","author":"Nowicka","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib211","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41232-021-00167-6","article-title":"Updates on genetics in systemic sclerosis","volume":"41","author":"Ota","year":"2021","journal-title":"Inflamm. Regen."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib212","first-page":"300","article-title":"Chromosomal abnormalities in progressive systemic sclerosis (scleroderma) with consideration of radiation effects","volume":"86","author":"Pan","year":"1975","journal-title":"J. Lab Clin. Med"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib213","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/cei.13566","article-title":"Variety of endosomal TLRs and Interferons (IFN-\u03b1, IFN-\u03b2, IFN-\u03b3) expression profiles in patients with SLE, SSc and MCTD","volume":"204","author":"Paradowska-Gorycka","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib214","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of Systemic Sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib215","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1038\/s41467-022-34775-8","article-title":"Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis","volume":"13","author":"Paul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102812_bib216","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.freeradbiomed.2014.09.028","article-title":"Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells","volume":"77","author":"Pazmandi","year":"2014","journal-title":"Free Radic. Biol. Med"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib217","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-022-01569-x","article-title":"Targeting TGF-\u03b2 signal transduction for fibrosis and cancer therapy","volume":"21","author":"Peng","year":"2022","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165761","article-title":"Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases","volume":"1866","author":"P\u00e9rez-Trevi\u00f1o","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"44","key":"10.1016\/j.arr.2025.102812_bib219","doi-asserted-by":"crossref","first-page":"E6823","DOI":"10.1073\/pnas.1612047113","article-title":"Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors","volume":"113","author":"Perkins","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib220","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib221","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41467-019-10970-y","article-title":"A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription","volume":"10","author":"Platanitis","year":"2019","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.arr.2025.102812_bib222","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib223","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tim.2016.01.005","article-title":"Harnessing the prokaryotic adaptive immune system as a eukaryotic antiviral defense","volume":"24","author":"Price","year":"2016","journal-title":"Trends Microbiol"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib224","first-page":"33","article-title":"Serological and clinical profile of systemic sclerosis: analysis in a cohort of patients from a single center in Northern Italy","volume":"153","author":"Priora","year":"2018","journal-title":"G Ital. Dermatol. Venereol."},{"issue":"51","key":"10.1016\/j.arr.2025.102812_bib225","doi-asserted-by":"crossref","first-page":"17588","DOI":"10.1074\/jbc.REV120.015101","article-title":"Visualizing, quantifying, and manipulating mitochondrial DNA in vivo","volume":"295","author":"Prole","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib226","first-page":"292","article-title":"Relationship between inflammation and oxidative stress and its effect on multiple sclerosis","volume":"39","author":"Ramos-Gonz\u00e1lez","year":"2024","journal-title":"Neurol. (Engl. Ed."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101815","article-title":"Phosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction","volume":"298","author":"Reardon","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"3-6","key":"10.1016\/j.arr.2025.102812_bib228","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0921-8734(92)90029-O","article-title":"Reactive oxygen and DNA damage in mitochondria","volume":"275","author":"Richter","year":"1992","journal-title":"Mutat. Res"},{"key":"10.1016\/j.arr.2025.102812_bib229","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/976427","article-title":"Primary biliary cirrhosis associated with systemic sclerosis: diagnostic and clinical challenges","volume":"2011","author":"Rigamonti","year":"2011","journal-title":"Int J. Rheuma"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib230","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949799","article-title":"Mitochondrial DNA in inflammation and immunity","volume":"21","author":"Riley","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2025.102812_bib231","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1066375","article-title":"Dysregulation of the immune response in TGF-\u03b2 signalopathies","volume":"13","author":"Rodari","year":"2022","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib232","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/kjm2.12505","article-title":"Pathophysiology of systemic sclerosis (scleroderma)","volume":"38","author":"Rosendahl","year":"2022","journal-title":"Kaohsiung J. Med Sci."},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib233","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/annrheumdis-2020-218439","article-title":"Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma","volume":"80","author":"Ross","year":"2021","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib234","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/art.41418","article-title":"Bioactive Plasma Mitochondrial DNA Is associated with disease progression in scleroderma-associated interstitial lung disease","volume":"72","author":"Ryu","year":"2020","journal-title":"Arthritis Rheuma"},{"issue":"49","key":"10.1016\/j.arr.2025.102812_bib235","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1073\/pnas.1520997112","article-title":"Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis","volume":"112","author":"Saigusa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib236","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10843-8","article-title":"Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells","volume":"7","author":"Sasaki","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib237","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41418-024-01260-2","article-title":"Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy","volume":"31","author":"Saunders","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.arr.2025.102812_bib238","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1132653","article-title":"cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging","volume":"14","author":"Schmitz","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib239","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev. Immunol."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib240","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/jcm9061995","article-title":"Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets","volume":"9","author":"Scioli","year":"2020","journal-title":"J. Clin. Med"},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib241","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/ard.2006.067504","article-title":"Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis","volume":"66","author":"Servettaz","year":"2007","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib242","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.4049\/jimmunol.0803705","article-title":"Selective oxidation of DNA topoisomerase 1 induces systemic sclerosis in the mouse","volume":"182","author":"Servettaz","year":"2009","journal-title":"J. Immunol."},{"issue":"5(5)","key":"10.1016\/j.arr.2025.102812_bib243","doi-asserted-by":"crossref","first-page":"v5","DOI":"10.1093\/rheumatology\/ken275","article-title":"Pro- and anti-fibrotic effects of TGF-beta in scleroderma","volume":"47","author":"Sgonc","year":"2008","journal-title":"Rheumatol. (Oxf. )"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib244","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2353\/ajpath.2008.071163","article-title":"Expression and maintenance of mitochondrial DNA: new insights into human disease pathology","volume":"172","author":"Shadel","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib245","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12964-023-01274-2","article-title":"RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS\/STING\/NF-\u03baB pathway","volume":"21","author":"Shao","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"710","key":"10.1016\/j.arr.2025.102812_bib246","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abe4627","article-title":"IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs","volume":"14","author":"Shemesh","year":"2021","journal-title":"Sci. Signal"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib247","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib248","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/biology12020285","article-title":"Molecular mechanisms behind the role of plasmacytoid dendritic cells in systemic sclerosis","volume":"12","author":"Silva","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.arr.2025.102812_bib249","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12688\/f1000research.6665.1","article-title":"Mitochondrial DNA Damage and Diseases","volume":"4","author":"Singh","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.arr.2025.102812_bib250","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2018.12.018","article-title":"Type I interferon dysregulation in systemic sclerosis","volume":"132","author":"Skaug","year":"2020","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib251","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/annrheumdis-2019-215894","article-title":"Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile","volume":"79","author":"Skaug","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib252","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1038\/s41598-020-64865-w","article-title":"The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent","volume":"10","author":"Skopelja-Gardner","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib253","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-022-00589-6","article-title":"Role of the cGAS-STING pathway in systemic and organ-specific diseases","volume":"18","author":"Skopelja-Gardner","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib254","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102515","article-title":"Diagnostic profiles for precision medicine in systemic sclerosis; stepping forward from single biomarkers towards pathophysiological panels","volume":"19","author":"Smeets","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib255","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense","volume":"25","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2025.102812_bib256","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2024.102395","article-title":"New advances in innate immune endosomal trafficking","volume":"89","author":"Stocks","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib257","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-10-43","article-title":"Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice","volume":"10","author":"Stowell","year":"2009","journal-title":"Respir. Res"},{"key":"10.1016\/j.arr.2025.102812_bib258","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1127704","article-title":"Immunomodulation-a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system","volume":"14","author":"Strzelec","year":"2023","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib259","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00018-010-0530-4","article-title":"Mitochondrial DNA replication and disease: insights from DNA polymerase \u03b3 mutations","volume":"68","author":"Stumpf","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102812_bib260","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102812_bib261","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.04.554","article-title":"NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis","volume":"125","author":"Svegliati","year":"2018","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.arr.2025.102812_bib262","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jaut.2018.09.008","article-title":"White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study","volume":"96","author":"Svendsen","year":"2019","journal-title":"J. Autoimmun."},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib263","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0005-2728(98)00161-3","article-title":"The mitochondrial genome: structure, transcription, translation and replication","volume":"1410","author":"Taanman","year":"1999","journal-title":"Biochim Biophys. Acta"},{"issue":"Pt 4","key":"10.1016\/j.arr.2025.102812_bib264","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1242\/jcs.099234","article-title":"Mitochondria and cell signalling","volume":"125","author":"Tait","year":"2012","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib265","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib266","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102812_bib267","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0065-2776(08)60641-0","article-title":"Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology","volume":"44","author":"Tan","year":"1989","journal-title":"Adv. Immunol."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib268","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.65.8.16","article-title":"H-151, a Selective STING inhibitor, has potential as a treatment for neovascular age-related macular degeneration","volume":"65","author":"Tanaka","year":"2024","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"214","key":"10.1016\/j.arr.2025.102812_bib269","doi-asserted-by":"crossref","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib270","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24029","article-title":"Advances in crosstalk among innate immune pathways activated by mitochondrial DNA","volume":"10","author":"Tao","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib271","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10577-010-9179-y","article-title":"Chromosomes and cancer cells","volume":"19","author":"Thompson","year":"2011","journal-title":"Chromosome Res"},{"key":"10.1016\/j.arr.2025.102812_bib272","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3389\/fimmu.2018.01985","article-title":"A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis","volume":"9","author":"Thuan","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib273","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3389\/fimmu.2018.01985","article-title":"A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis","volume":"9","author":"Thuan","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102812_bib274","article-title":"The role of the cGAS-STING pathway in chronic pulmonary inflammatory diseases","volume":"11","author":"Tian","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib275","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1755-1536-5-11","article-title":"Molecular and cellular mechanisms of pulmonary fibrosis","volume":"5","author":"Todd","year":"2012","journal-title":"Fibrogenes. Tissue Repair"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib276","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00018-024-05214-2","article-title":"When DNA-damage responses meet innate and adaptive immunity","volume":"81","author":"Tong","year":"2024","journal-title":"Cell Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib277","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10577-023-09732-w","article-title":"Consequences of gaining an extra chromosome","volume":"31","author":"Torres","year":"2023","journal-title":"Chromosome Res"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib278","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2217\/thy.09.2","article-title":"Endosomal Toll-like receptors in autoimmunity: mechanisms for clinical diversity","volume":"6","author":"Trivedi","year":"2009","journal-title":"Therapy"},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib279","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12016-021-08889-8","article-title":"Current concepts on the pathogenesis of systemic sclerosis","volume":"64","author":"Truchetet","year":"2023","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib280","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.4049\/jimmunol.2000596","article-title":"The role of cutaneous type I IFNs in autoimmune and autoinflammatory diseases","volume":"205","author":"Turnir","year":"2020","journal-title":"J. Immunol."},{"issue":"21","key":"10.1016\/j.arr.2025.102812_bib281","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and type I interferons","volume":"282","author":"Uematsu","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib282","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1586\/eci.11.39","article-title":"Fibroblast abnormalities in the pathogenesis of systemic sclerosis","volume":"7","author":"Usategui","year":"2011","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib283","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nrrheum.2009.26","article-title":"Transforming growth factor beta as a therapeutic target in systemic sclerosis","volume":"5","author":"Varga","year":"2009","journal-title":"Nat. Rev. Rheuma"},{"issue":"22","key":"10.1016\/j.arr.2025.102812_bib284","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"Verrecchia","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.arr.2025.102812_bib285","unstructured":"Vincent J., Adura C., Gao P., Luz A., Lama L., Asano Y., Okamoto R., Imaeda T., Aida J., Rothamel K., Gogakos T., Steinberg J., Reasoner S., Aso K., Tuschl T., Patel D.J., Glickman J.F., Ascano M. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. (2025)."},{"issue":"10373","key":"10.1016\/j.arr.2025.102812_bib286","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0140-6736(22)01692-0","article-title":"Systemic sclerosis","volume":"401","author":"Volkmann","year":"2023","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib287","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1111\/jcmm.13630","article-title":"Oxidative stress in the pathogenesis of systemic scleroderma: an overview","volume":"22","author":"Vona","year":"2018","journal-title":"J. Cell Mol. Med"},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib288","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1134\/S0006297920100065","article-title":"NETosis: molecular mechanisms, role in physiology and pathology","volume":"85","author":"Vorobjeva","year":"2020","journal-title":"Biochemistry (Mosc"},{"issue":"10143","key":"10.1016\/j.arr.2025.102812_bib289","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(18)31363-1","article-title":"Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"392","author":"Wallace","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2025.102812_bib290","article-title":"The effect of TLR9, MyD88, and NF-\u03baB p65 in systemic lupus erythematosus","volume":"2022","author":"Wang","year":"2022","journal-title":"Evid. Based Complement Altern. Med"},{"issue":"12","key":"10.1016\/j.arr.2025.102812_bib291","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/art.40576","article-title":"Association of abnormal elevations in IFIT3 with overactive cyclic GMP-AMP synthase\/stimulator of interferon genes signaling in human systemic lupus erythematosus monocytes","volume":"70","author":"Wang","year":"2018","journal-title":"Arthritis Rheuma"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib292","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.3390\/ijms24043896","article-title":"Oxidized mitochondrial DNA engages TLR9 to activate the NLRP3 inflammasome in myelodysplastic syndromes","volume":"24","author":"Ward","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib293","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.3390\/ijms24065564","article-title":"Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight","volume":"24","author":"Waseem","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102812_bib294","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2016.08.005","article-title":"Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria","volume":"31","author":"Waseem","year":"2016","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib295","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arcmed.2017.01.010","article-title":"Mitochondria as the target for the modulatory effect of curcumin in oxaliplatin-induced toxicity in isolated rat liver mitochondria","volume":"48","author":"Waseem","year":"2017","journal-title":"Arch. Med Res"},{"issue":"7","key":"10.1016\/j.arr.2025.102812_bib296","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180953","article-title":"Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death","volume":"12","author":"Waseem","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib297","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"7548","key":"10.1016\/j.arr.2025.102812_bib298","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib299","doi-asserted-by":"crossref","first-page":"a015818","DOI":"10.1101\/cshperspect.a015818","article-title":"The centromere: epigenetic control of chromosome segregation during mitosis","volume":"7","author":"Westhorpe","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.arr.2025.102812_bib300","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41577-022-00787-0","article-title":"Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases","volume":"23","author":"Wigerblad","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib301","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/genes11060642","article-title":"DNA replication stress and chromosomal instability: dangerous liaisons","volume":"11","author":"Wilhelm","year":"2020","journal-title":"Genes"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib302","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109977","article-title":"TNF leads to mtDNA release and cGAS\/STING-dependent interferon responses that support inflammatory arthritis","volume":"37","author":"Willemsen","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2025.102812_bib303","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.905109","article-title":"Dysregulation of the cGAS-STING pathway in monogenic autoinflammation and lupus","volume":"13","author":"Wobma","year":"2022","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib304","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119317","article-title":"Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane","volume":"1869","author":"Wolf","year":"2022","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib305","first-page":"837","article-title":"Spontaneous and clastogen induced chromosomal breakage in scleroderma","volume":"18","author":"Wolff","year":"1991","journal-title":"J. Rheuma"},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib306","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s40674-021-00188-9","article-title":"Dysregulation of Type 1 interferon signaling in systemic sclerosis: a promising therapeutic target?","volume":"7","author":"Wu","year":"2021","journal-title":"Curr. Treatm Opt. Rheuma"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib307","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2025.102812_bib308","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1267091","article-title":"The role of inflammation in autoimmune disease: a therapeutic target","volume":"14","author":"Xiang","year":"2023","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib309","doi-asserted-by":"crossref","first-page":"C550","DOI":"10.1152\/ajpcell.00123.2010","article-title":"Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis","volume":"300","author":"Xu","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib310","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.exer.2007.06.013","article-title":"Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells","volume":"85","author":"Yang","year":"2007","journal-title":"Exp. Eye Res"},{"issue":"23","key":"10.1016\/j.arr.2025.102812_bib311","doi-asserted-by":"crossref","first-page":"E4612","DOI":"10.1073\/pnas.1705499114","article-title":"cGAS is essential for cellular senescence","volume":"114","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102812_bib312","article-title":"Advances in cGAS-STING signaling pathway and diseases","volume":"10","author":"Yang","year":"2022","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.arr.2025.102812_bib313","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.2147\/IJGM.S356877","article-title":"Epigenetic modifications in the pathogenesis of systemic sclerosis","volume":"15","author":"Yu","year":"2022","journal-title":"Int J. Gen. Med"},{"key":"10.1016\/j.arr.2025.102812_bib314","doi-asserted-by":"crossref","unstructured":"Yu S., Hu B., Sun Y., Peng X.Y., Lee C.J., Woo S., McGovern J., Zielonka J., Saber T., Ghincea A., Gandhi S., Walia A., Pivarnik T., Ishikawa G., Shuai S., Sun H., Gunes B.I., Kujawski S., Perez S., Odell W., Hinchcliff M., Varga J., Bostwick C.F., Sauler M., Gomez J.L., Ryu C., Herzog E.L. cGAS Expression is Enhanced in Systemic Sclerosis Associated Interstitial Lung Disease and Stimulates Inflammatory Myofibroblast Activation. medRxiv [Preprint]. 2024 Aug 8:2024.08.07.24311631.","DOI":"10.1101\/2024.08.07.24311631"},{"issue":"2","key":"10.1016\/j.arr.2025.102812_bib315","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1042\/BST20221010","article-title":"Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?","volume":"51","author":"Zanini","year":"2023","journal-title":"Biochem Soc. Trans."},{"key":"10.1016\/j.arr.2025.102812_bib316","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.21490.1","article-title":"Recent advances in understanding mitochondrial genome diversity","volume":"9","author":"Zardoya","year":"2020","journal-title":"F1000Res"},{"issue":"7748","key":"10.1016\/j.arr.2025.102812_bib317","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-019-1000-2","article-title":"Structural basis of STING binding with and phosphorylation by TBK1","volume":"567","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.arr.2025.102812_bib318","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1111\/1756-185X.14876","article-title":"Mitochondrial displacement loop region single nucleotide polymorphisms and mitochondrial DNA copy number associated with risk of ankylosing spondylitis","volume":"26","author":"Zhang","year":"2023","journal-title":"Int J. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.arr.2025.102812_bib319","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.2300758","article-title":"Mitochondrial DNA programs lactylation of cGAS to induce IFN responses in patients with systemic lupus erythematosus","volume":"213","author":"Zhang","year":"2024","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib320","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155761","article-title":"Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex","volume":"7","author":"Zhang","year":"2022","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.arr.2025.102812_bib321","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29013","article-title":"NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1","volume":"95","author":"Zhang","year":"2023","journal-title":"J. Med Virol."},{"key":"10.1016\/j.arr.2025.102812_bib322","article-title":"Inflammasomes and Fibrosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol."},{"issue":"7758","key":"10.1016\/j.arr.2025.102812_bib323","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41586-019-1228-x","article-title":"A conserved PLPLRT\/SD motif of STING mediates the recruitment and activation of TBK1","volume":"569","author":"Zhao","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.arr.2025.102812_bib324","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1021\/acs.chemrestox.0c00083","article-title":"Mitochondrial DNA damage: prevalence, biological consequence, and emerging pathways","volume":"33","author":"Zhao","year":"2020","journal-title":"Chem. Res Toxicol."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib325","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.arr.2025.102812_bib326","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1007\/s00415-022-11146-3","article-title":"Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases","volume":"269","author":"Zhao","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.arr.2025.102812_bib327","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijbiomac.2020.12.127","article-title":"The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways","volume":"169","author":"Zheng","year":"2021","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102812_bib328","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-0716-4108-8_13","article-title":"DNA PAMPs as molecular tools for the cGAS-STING signaling pathways","volume":"2854","author":"Zheng","year":"2025","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.arr.2025.102812_bib329","first-page":"1145","article-title":"The role of cGAS-STING in age-related diseases from mechanisms to therapies","volume":"14","author":"Zheng","year":"2023","journal-title":"Aging Dis."},{"issue":"7717","key":"10.1016\/j.arr.2025.102812_bib330","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.arr.2025.102812_bib331","doi-asserted-by":"crossref","first-page":"13316","DOI":"10.3390\/ijms241713316","article-title":"Significance of the cGAS-STING pathway in health and disease","volume":"24","author":"Zhou","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102812_bib332","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12964-021-00738-7","article-title":"Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway","volume":"19","author":"Zhou","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102812_bib333","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2019.104094","article-title":"The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseases","volume":"77","author":"Zhou","year":"2020","journal-title":"Infect. Genet Evol."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib334","doi-asserted-by":"crossref","first-page":"609","DOI":"10.21037\/cdt-23-123","article-title":"Apoptosis-inducing factor: a mitochondrial protein associated with metabolic diseases-a narrative review","volume":"13","author":"Zong","year":"2023","journal-title":"Cardiovasc Diagn. Ther."},{"issue":"3","key":"10.1016\/j.arr.2025.102812_bib335","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:31:30Z","timestamp":1788949890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725001588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":335,"alternative-id":["S1568163725001588"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102812","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between oxidative stress, mitochondrial dysfunction, chromosome instability, and the activation of the cGAS-STING\/IFN pathway in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102812"}}