{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:44:30Z","timestamp":1793508270234,"version":"4.5.0"},"reference-count":183,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.arr.2025.102838","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T05:53:17Z","timestamp":1753077197000},"page":"102838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["The evolution of Alzheimer\u2019s disease: From mitochondria to microglia"],"prefix":"10.1016","volume":"111","author":[{"given":"Feng-ge","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-lin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-yan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2025.102838_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2022.06.229","article-title":"Redox biology in neurodegenerative disorders","volume":"188","author":"Abramov","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.arr.2025.102838_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnagi.2020.00252","article-title":"Mitochondrial dysfunction and Alzheimer's disease: role of microglia","volume":"12","author":"Agrawal","year":"2020","journal-title":"Front. Aging Neurosci."},{"issue":"19","key":"10.1016\/j.arr.2025.102838_bib3","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.3390\/ijms221910519","article-title":"ROS\/TNF-\u03b1 crosstalk triggers the expression of IL-8 and MCP-1 in human monocytic THP-1 Cells via the NF-\u03baB and ERK1\/2 mediated signaling","volume":"22","author":"Akhter","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.arr.2025.102838_bib4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/membranes12090893","article-title":"Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders","volume":"12","author":"Al Ojaimi","year":"2022","journal-title":"Membranes (Basel)"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jalz.2016.12.006","article-title":"Calcium hypothesis of Alzheimer's disease and brain aging: a framework for integrating new evidence into a comprehensive theory of pathogenesis","volume":"13","author":"Alzheimer's Association Calcium Hypothesis Workgroup","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib6","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer\u2019s disease facts and figures","volume":"18","author":"Alzheimer\u2019s Association, 2022.","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib7","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer\u2019s disease facts and figures","volume":"20","author":"Alzheimer's Association, 2024.","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/15548627.2018.1532259","article-title":"PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis","volume":"15","author":"Araya","year":"2019","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib9","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.3390\/ijms23073785","article-title":"Brain metabolic alterations in Alzheimer's disease","volume":"23","author":"Ardanaz","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1096\/fj.201601309","article-title":"On the pathogenesis of Alzheimer's disease: the MAM hypothesis","volume":"201731","author":"Area-Gomez","year":"2017","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bj.2022.05.002","article-title":"Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases","volume":"45","author":"Bhatti","year":"2022","journal-title":"Biomed. J."},{"issue":"13","key":"10.1016\/j.arr.2025.102838_bib12","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.3390\/ijms23136954","article-title":"Role of impaired mitochondrial dynamics processes in the pathogenesis of Alzheimer's disease","volume":"23","author":"Blagov","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.arr.2025.102838_bib13","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1080\/15548627.2016.1239003","article-title":"Autophagy flux in CA1 neurons of Alzheimer hippocampus: increased induction overburdens failing lysosomes to propel neuritic dystrophy","volume":"12","author":"Bordi","year":"2016","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molmed.2019.10.007","article-title":"Regulation of mitochondrial ATP production: Ca2+ signaling and quality control","volume":"26","author":"Boyman","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib15","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","article-title":"Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease","volume":"11","author":"Calvo-Rodriguez","year":"2020","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.arr.2025.102838_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70285","article-title":"Melatonin reduces mito-inflammation in ischaemic hippocampal HT22 Cells and modulates the cGAS-STING cytosolic DNA sensing pathway and FGF21 release","volume":"28","author":"Carloni","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.arr.2025.102838_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2024.102693","article-title":"Purinergic-associated immune responses in neurodegenerative diseases","volume":"243","author":"Carracedo","year":"2024","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s40520-019-01209-3","article-title":"Vitamin E and Alzheimer's disease: the mediating role of cellular aging","volume":"32","author":"Casati","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56614-5","article-title":"Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer's disease and mild cognitive impairment","volume":"9","author":"Castellazzi","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib20","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/antiox10050774","article-title":"Melatonin successfully rescues the hippocampal molecular machinery and enhances anti-oxidative activity following early-life sleep deprivation injury","volume":"10","author":"Chang","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1124\/jpet.118.253310","article-title":"Icariin delays brain aging in senescence-accelerated mouse prone 8 (SAMP8) model via inhibiting autophagy","volume":"369","author":"Chen","year":"2019","journal-title":"J. Pharm. Exp. Ther."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","article-title":"Early glycolytic reprogramming controls microglial inflammatory activation","volume":"18","author":"Cheng","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2025.102838_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fphys.2020.00598","article-title":"Involvement of Lipids in Alzheimer's disease pathology and potential therapies","volume":"11","author":"Chew","year":"2020","journal-title":"Front. Physiol."},{"issue":"14","key":"10.1016\/j.arr.2025.102838_bib24","doi-asserted-by":"crossref","first-page":"7952","DOI":"10.3390\/ijms25147952","article-title":"Targeting mitochondrial dysfunction and reactive oxygen species for neurodegenerative disease treatment","volume":"25","author":"Choi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102838_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2050435","article-title":"Green tea polyphenols attenuated glutamate excitotoxicity via antioxidative and antiapoptotic pathway in the primary cultured cortical neurons","author":"Cong","year":"2016","journal-title":"Oxid. Med Cell Longev."},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib26","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3233\/JAD-161256","article-title":"Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial","volume":"57","author":"Craft","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2025.102838_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3389\/fnhum.2018.00416","article-title":"Can transcranial direct-current stimulation alone or combined with cognitive training be used as a clinical intervention to improve cognitive functioning in persons with mild cognitive impairment and dementia? A systematic review and meta-analysis","volume":"12","author":"Cruz Gonzalez","year":"2018","journal-title":"Front Hum. Neurosci."},{"issue":"02","key":"10.1016\/j.arr.2025.102838_bib28","first-page":"29","article-title":"Effect of Yishen Tiaodu acupuncture on mitochondrial COX\u2163 in hippocampus of AD","volume":"37","author":"Cui","year":"2014","journal-title":"Model Rats. J. Chengdu Univ. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib29","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899360","article-title":"Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria","volume":"38","author":"Cummins","year":"2019","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.arr.2025.102838_bib30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9-10","key":"10.1016\/j.arr.2025.102838_bib31","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s10495-024-01977-y","article-title":"Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications","volume":"29","author":"D'Arcy","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.arr.2025.102838_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101910","article-title":"Kaempferol as a therapeutic agent in Alzheimer's disease: evidence from preclinical studies","volume":"87","author":"Dong","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"18","key":"10.1016\/j.arr.2025.102838_bib33","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.3390\/ijms251810220","article-title":"NMDARs in Alzheimer's disease: between synaptic and extrasynaptic membranes","volume":"25","author":"Escamilla","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.arr.2025.102838_bib34","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.3390\/ijms21249521","article-title":"Molecular dysfunctions of mitochondria-associated membranes (MAMs) in Alzheimer's Disease","volume":"21","author":"Eysert","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102838_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624538","article-title":"Mitochondrial regulation of microglial immunometabolism in Alzheimer\u2019s disease","volume":"12","author":"Fairley","year":"2021","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209177120","article-title":"Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease","volume":"120","author":"Fairley","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7810","key":"10.1016\/j.arr.2025.102838_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41586-020-2309-6","article-title":"Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex","volume":"582","author":"Fan","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer's disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2024.2410968","article-title":"Single domain antibody-scFv conjugate targeting amyloid \u03b2 and TfR penetrates the blood-brain barrier and interacts with amyloid \u03b2","volume":"16","author":"Faresj\u00f6","year":"2024","journal-title":"MAbs"},{"key":"10.1016\/j.arr.2025.102838_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-7-45","article-title":"Effects of mitochondrial dysfunction on the immunological properties of microglia","volume":"7","author":"Ferger","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2025.102838_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2054783","article-title":"Cend1, a story with many tales: from regulation of cell cycle progression\/exit of neural stem cells to brain structure and function","author":"Gaitanou","year":"2019","journal-title":"Stem Cells Int"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib42","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/life12030401","article-title":"From the structural and (Dys) function of ATP synthase to deficiency in age-related diseases","volume":"12","author":"Garone","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.arr.2025.102838_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejphar.2015.07.001","article-title":"Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms","volume":"764","author":"Ghofrani","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102838_bib44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(18)30028-0","article-title":"Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study","volume":"17","author":"Gordon","year":"2018","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.arr.2025.102838_bib46","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1177\/0271678X15610584","article-title":"Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity","volume":"36","author":"Greco","year":"2016","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib47","doi-asserted-by":"crossref","first-page":"a041046","DOI":"10.1101\/cshperspect.a041046","article-title":"The mitochondrial pathway of apoptosis part II: the BCL-2 protein family","volume":"14","author":"Green","year":"2022","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib48","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.3390\/ijms22115900","article-title":"Elevating the levels of calcium ions exacerbate Alzheimer's disease via inducing the production and aggregation of \u03b2-amyloid protein and phosphorylated tau","volume":"22","author":"Guan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102838_bib49","article-title":"Clinical observation of Jiawei Kaixin powder in the treatment of Alzheimer's disease with spleen deficiency and phlegm obstruction","volume":"1","author":"Guan","year":"2022","journal-title":"Sdutcm. MA Thesis"},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib50","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/antiox10040595","article-title":"Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) gene variants analysis in an obese population: a preliminary case-control study","volume":"10","author":"Gusti","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"immuni"},{"key":"10.1016\/j.arr.2025.102838_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110215","article-title":"Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction","volume":"762","author":"Han","year":"2024","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.arr.2025.102838_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.873929","article-title":"Dihuang-Yinzi alleviates cognition deficits via targeting energy-related metabolism in an alzheimer mouse model as demonstrated by integration of metabolomics and network pharmacology","volume":"14","author":"Han","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib54","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s11011-020-00587-2","article-title":"\u03b2-Asarone improves learning and memory in A\u03b21-42-induced Alzheimer's disease rats by regulating PINK1-Parkin-mediated mitophagy","volume":"35","author":"Han","year":"2020","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib55","first-page":"217","article-title":"Effects of acupuncture on mitochondrial calcium ion concentration and reactive oxygen species in rapidly aging rats","volume":"32","author":"Hao","year":"2013","journal-title":"J. Tianjin Med. Univ."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.immuni.2021.12.001","article-title":"Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function","volume":"55","author":"He","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2025.102838_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115807","article-title":"The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges","volume":"168","author":"He","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.arr.2025.102838_bib58","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.conb.2015.12.004","article-title":"New insights on the role of microglia in synaptic pruning in health and disease","volume":"36","author":"Hong","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization\u2014new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib60","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1002\/alz.13058","article-title":"Low glucose induced Alzheimer's disease-like biochemical changes in human induced pluripotent stem cell-derived neurons is due to dysregulated O-GlcNAcylation","volume":"19","author":"Huang","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2025.102838_bib61","article-title":"Clinical observation of Yishen Tiaodu acupuncture in the treatment of mild cognitive impairment","volume":"2","author":"Huang","year":"2017","journal-title":"Hbucm. MA Thesis"},{"issue":"12","key":"10.1016\/j.arr.2025.102838_bib62","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/metabo14120723","article-title":"Circadian influences on brain lipid metabolism and neurodegenerative diseases","volume":"14","author":"Hussain","year":"2024","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib63","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib64","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3390\/biom13111577","article-title":"Mechanisms of the beneficial effects of exercise on brain-derived neurotrophic factor expression in Alzheimer's Disease","volume":"13","author":"Jaberi","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib65","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1038\/s41467-019-11813-6","article-title":"Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease","volume":"10","author":"Jadiya","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102838_bib66","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s disease: Etiopathogenesis and treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib67","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41593-020-00774-5","article-title":"Author correction: fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration","volume":"24","author":"Joshi","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102838_bib68","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and herapeutic strategies for Alzheimer's disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2025.102838_bib69","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.expneurol.2012.06.003","article-title":"Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system","volume":"246","author":"Kanaan","year":"2013","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib70","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/hmg\/ddab360","article-title":"A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease","volume":"31","author":"Kandimalla","year":"2022","journal-title":"Hum. Mol. Genet"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib71","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1038\/s41598-017-05232-0","article-title":"Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation","volume":"7","author":"Katoh","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102838_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101904","article-title":"Multifaceted role of dynamin-related protein 1 in cardiovascular disease: from mitochondrial fission to therapeutic interventions","volume":"78","author":"Kaur","year":"2024","journal-title":"Mitochondrion"},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib73","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1586\/ern.09.28","article-title":"Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein","volume":"9","author":"Kawahara","year":"2009","journal-title":"Expert Rev. Neurother."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib74","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.arr.2025.102838_bib75","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/1389450118666170816124203","article-title":"Mitochondrial aconitase in neurodegenerative disorders: role of a metabolism- related molecule in neurodegeneration","volume":"19","author":"Khodagholi","year":"2018","journal-title":"Curr. Drug Targets"},{"issue":"15","key":"10.1016\/j.arr.2025.102838_bib76","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.molcel.2022.06.004","article-title":"Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1","volume":"82","author":"Killackey","year":"2022","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib77","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.bbamcr.2016.09.003","article-title":"A\u03b2-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis","volume":"1863","author":"Kim","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib78","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10571-016-0434-4","article-title":"Relationship between \u03b2-amyloid and mitochondrial dynamics","volume":"37","author":"Kim","year":"2017","journal-title":"Cell Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib79","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.3390\/ijms23074004","article-title":"Epigallocatechin gallate protects against hypoxia-induced inflammation in microglia via NF-\u03baB suppression and Nrf-2\/HO-1 activation","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.arr.2025.102838_bib80","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","article-title":"Glucose transporters in brain in health and disease","volume":"472","author":"Koepsell","year":"2020","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.arr.2025.102838_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2025.102038","article-title":"Beneficial effects of mitophagy enhancers on amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer's disease","volume":"83","author":"Kshirsagar","year":"2025","journal-title":"Mitochondrion"},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib82","first-page":"499","article-title":"Innate immune recognition, integrated stress response, infection, and tumorigenesis","volume":"12","author":"Kubelkova","year":"2023","journal-title":"Biol. (Basel)"},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib83","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib84","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40035-022-00280-7","article-title":"Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson's disease patients","volume":"11","author":"Li","year":"2022","journal-title":"Transl. Neurodegener."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib85","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1186\/s12967-024-05571-3","article-title":"Gene therapy in A\u03b2-induced cell and mouse models of Alzheimer's disease through compensating defective mitochondrial complex I function","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"issue":"22","key":"10.1016\/j.arr.2025.102838_bib86","first-page":"18","article-title":"Curative effect of Dihuangyinzi on senile dementia","volume":"31","author":"Li","year":"2012","journal-title":"Inn. Mong. Med. J."},{"issue":"18","key":"10.1016\/j.arr.2025.102838_bib87","first-page":"2736","article-title":"Effect of acupuncture combined with Baduanjin on behavioral ability and cognitive function in patients with Alzheimer's disease","volume":"18","author":"Li","year":"2021","journal-title":"Lab Med Clin."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib88","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/thno.49860","article-title":"Se, lective autophagy of intracellular organelles: recent research advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib89","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3390\/antiox11071350","article-title":"Ebselen interferes with Alzheimer's disease by regulating mitochondrial function","volume":"11","author":"Li","year":"2022","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib90","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12974-022-02613-9","article-title":"Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflamm."},{"issue":"17","key":"10.1016\/j.arr.2025.102838_bib91","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5716","article-title":"Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function","volume":"8","author":"Lie","year":"2022","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib92","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1136\/jnnp-2014-308577","article-title":"CSF lactate levels, \u03c4 proteins, cognitive decline: a dynamic relationship in Alzheimer's disease","volume":"86","author":"Liguori","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib93","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib94","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet"},{"issue":"13","key":"10.1016\/j.arr.2025.102838_bib95","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib96","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102838_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103417","article-title":"Glial mitochondrial function and dysfunction in health and neurodegeneration","volume":"101","author":"McAvoy","year":"2019","journal-title":"Mol. Cell Neurosci."},{"issue":"23","key":"10.1016\/j.arr.2025.102838_bib98","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1021\/acs.jpcb.0c01712","article-title":"Identification of structural calcium binding sites in membrane-bound Presenilin 1 and 2","volume":"124","author":"Mehra","year":"2020","journal-title":"J. Phys. Chem. B"},{"issue":"1-3","key":"10.1016\/j.arr.2025.102838_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.10.032","article-title":"Excitotoxicity: bridge to various triggers in neurodegenerative disorders","volume":"698","author":"Mehta","year":"2013","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/cells10020347","article-title":"The role of DJ-1 in cellular metabolism and pathophysiological implications for Parkinson's disease","volume":"10","author":"Mencke","year":"2021","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib101","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.3168\/jds.2022-22907","article-title":"A high-concentrate diet induces mitochondrial dysfunction by activating the MAPK signaling pathway in the mammary gland of dairy cows","volume":"106","author":"Meng","year":"2023","journal-title":"J. Dairy Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib102","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/biomedicines11061752","article-title":"Nanomedicine in the management of Alzheimer's disease: state-of-the-art","volume":"11","author":"Mir Najib Ullah","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib103","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/biof.2013","article-title":"Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium\/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation","volume":"50","author":"Mohanad","year":"2024","journal-title":"Biofactors"},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib104","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/nu9070670","article-title":"Vitamin C, aging and Alzheimer's Disease","volume":"9","author":"Monacelli","year":"2017","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib105","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s12035-020-01926-1","article-title":"The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease","volume":"57","author":"Monzio Compagnoni","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102838_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2020.107230","article-title":"The role of L-type calcium channels in neuronal excitability and aging","volume":"173","author":"Moore","year":"2020","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.arr.2025.102838_bib107","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.freeradbiomed.2021.07.013","article-title":"Defective mitophagy and synaptic degeneration in Alzheimer's disease: focus on aging, mitochondria and synapse","volume":"172","author":"Morton","year":"2021","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.arr.2025.102838_bib108","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fnins.2018.00470","article-title":"Mitochondria and calcium regulation as basis of neurodegeneration associated with aging","volume":"12","author":"M\u00fcller","year":"2018","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib109","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3233\/JAD-171124","article-title":"Diet supplementation with hydroxytyrosol ameliorates brain pathology and restores cognitive functions in a mouse model of amyloid-\u03b2 deposition","volume":"63","author":"Nardiello","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"10","key":"10.1016\/j.arr.2025.102838_bib110","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib111","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10787-023-01391-x","article-title":"Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-\u03b1 and COX-2","volume":"32","author":"Nazar","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030782","article-title":"Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK","volume":"7","author":"Niu","year":"2012","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib113","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/jb\/mvx038","article-title":"Ca2+\/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262\/356 in a transgenic Drosophila model of tauopathy","volume":"162","author":"Oka","year":"2017","journal-title":"J. Biochem."},{"key":"10.1016\/j.arr.2025.102838_bib114","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2024.03.017","article-title":"Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging","volume":"217","author":"Olesen","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.arr.2025.102838_bib115","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/cells8090961","article-title":"Dynamics of dynamin-related protein 1 in Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"8","author":"Oliver","year":"2019","journal-title":"Cells"},{"issue":"s1","key":"10.1016\/j.arr.2025.102838_bib116","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.3233\/JAD-190048","article-title":"Molecular basis of Alzheimer's disease: focus on mitochondria","volume":"72","author":"Oliver","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2025.102838_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123142","article-title":"Brain microenvironment-remodeling nanomedicine improves cerebral glucose metabolism, mitochondrial activity and synaptic function in a mouse model of Alzheimer's disease","volume":"318","author":"Park","year":"2025","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib118","first-page":"364","article-title":"Effects of electroacupuncture on hippocampal mitochondria in SAMP8 mice","volume":"32","author":"Peng","year":"2007","journal-title":"Acupunct. Res."},{"key":"10.1016\/j.arr.2025.102838_bib119","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.arr.2025.102838_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer\u2019s disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib121","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202408581","article-title":"The mitochondria-targeted micelle inhibits Alzheimer's disease progression by alleviating neuronal mitochondrial dysfunction and neuroinflammation","volume":"21","author":"Qian","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib122","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12974-023-02866-y","article-title":"Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration","volume":"20","author":"Quick","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib123","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2174\/1570159X18666200525020259","article-title":"The role of mitochondrial impairment in Alzheimer\u2019s disease neurodegeneration:the Tau connection","volume":"18","author":"Quntanilla","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.arr.2025.102838_bib124","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.nbd.2015.03.018","article-title":"Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics","volume":"78","author":"Rao","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib125","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/jim-2016-000240","article-title":"Protective effects of a natural product, curcumin, against amyloid \u03b2 induced mitochondrial and synaptic toxicities in Alzheimer's disease","volume":"64","author":"Reddy","year":"2016","journal-title":"J. Invest. Med."},{"issue":"47","key":"10.1016\/j.arr.2025.102838_bib126","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.arr.2025.102838_bib127","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","article-title":"Oxidative stress occurs prior to amyloid A\u03b2 plaque formation and tau phosphorylation in Alzheimer's disease: role of glutathione and metal ions","volume":"14","author":"Roy","year":"2023","journal-title":"Acs. Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib128","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41420-021-00748-x","article-title":"BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-\u03b2","volume":"7","author":"Saha","year":"2021","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib129","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tcb.2016.09.005","article-title":"Hitchhiking: a non-canonical mode of microtubule-based transport","volume":"27","author":"Salogiannis","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib130","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/brain\/awad432","article-title":"New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease","volume":"147","author":"Samanta","year":"2024","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib131","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3233\/JAD-215108","article-title":"Mitochondrial targeting of Amyloid-\u03b2 protein precursor intracellular domain induces hippocampal cell death via a mechanism distinct from amyloid-\u03b2","volume":"86","author":"Sandberg","year":"2022","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib132","doi-asserted-by":"crossref","first-page":"401","DOI":"10.18632\/aging.101748","article-title":"3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice","volume":"11","author":"Sasaki","year":"2019","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib133","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-132543","article-title":"Amyloid-\u03b2 peptides are generated in mitochondria-associated endoplasmic reticulum membranes","volume":"43","author":"Schreiner","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2025.102838_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2022.577951","article-title":"The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation","volume":"371","author":"Serna-Rodr\u00edguez","year":"2022","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s100480050002","article-title":"Oxidative phosphorylation defects and Alzheimer's disease","volume":"1","author":"Shoffner","year":"1997","journal-title":"Neurogenetics"},{"key":"10.1016\/j.arr.2025.102838_bib136","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/antiox9080743","article-title":"ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease","volume":"9","author":"Simpson","year":"2020","journal-title":"Antioxid. Basel Switz."},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib137","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: a key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102838_bib138","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflamm."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib139","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/HYPERTENSIONAHA.120.15491","article-title":"Endothelial nitric oxide suppresses action-potential-like transient spikes and vasospasm in small resistance arteries","volume":"76","author":"Smith","year":"2020","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/cells14030229","article-title":"Mitochondrial alterations, oxidative stress, and therapeutic implications in Alzheimer's disease: a narrative review","volume":"14","author":"Spina","year":"2025","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.arr.2025.102838_bib141","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3390\/biom11121876","article-title":"Physiological and pathophysiological roles of mitochondrial Na+-Ca2+ exchanger, NCLX, in hearts","volume":"11","author":"Takeuchi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102838_bib142","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.921794","article-title":"Research progress in traditional Chinese medicine in the treatment of Alzheimer's disease and related dementias","volume":"13","author":"Tan","year":"2022","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib143","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.3390\/antiox12061282","article-title":"Therapeutic potential of heterocyclic compounds targeting mitochondrial calcium homeostasis and signaling in Alzheimer's disease and Parkinson's disease","volume":"12","author":"Tapias","year":"2023","journal-title":"Antioxid. (Basel)"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib144","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem"},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neurobiolaging.2013.08.003","article-title":"miR128 up-regulation correlates with impaired amyloid \u03b2(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease","volume":"35","author":"Tiribuzi","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"23","key":"10.1016\/j.arr.2025.102838_bib146","doi-asserted-by":"crossref","first-page":"12613","DOI":"10.3390\/ijms252312613","article-title":"Decoding neurodegeneration: a review of molecular mechanisms and therapeutic advances in Alzheimer's, Parkinson's, and ALS","volume":"25","author":"Toader","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.arr.2025.102838_bib147","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1007\/s12035-020-02065-3","article-title":"Emerging therapeutic promise of ketogenic diet to attenuate neuropathological alterations in Alzheimer's disease","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"15","key":"10.1016\/j.arr.2025.102838_bib148","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.3390\/ijms23158561","article-title":"Reduced VDAC1, maintained mitochondrial dynamics and enhanced mitochondrial biogenesis in a transgenic tau mouse model of Alzheimer's disease","volume":"23","author":"Vijayan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.arr.2025.102838_bib149","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/j.celrep.2018.10.103","article-title":"The mitochondrial apoptotic effectors BAX\/BAK activate caspase-3 and -7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1\u03b2 activation","volume":"25","author":"Vince","year":"2018","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.arr.2025.102838_bib150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib151","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12974-020-01976-1","article-title":"Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in A\u03b2-exposed U251 cells and APP\/PS1 mice","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib152","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s11064-014-1343-x","article-title":"Effects of long-term treatment with quercetin on cognition and mitochondrial function in a mouse model of Alzheimer's disease","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib153","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.stem.2019.09.009","article-title":"Brain endothelial cells maintain lactate homeostasis and control adult hippocampal neurogenesis","volume":"25","author":"Wang","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2025.102838_bib154","article-title":"Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2025.102838_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113412","article-title":"The role of microglia immunometabolism in neurodegeneration: focus on molecular determinants and metabolic intermediates of metabolic reprogramming","volume":"153","author":"Wang","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib156","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.3390\/ijms26052213","article-title":"Progress in AAV-mediated in vivo gene therapy and its applications in central nervous system diseases","volume":"26","author":"Wang","year":"2025","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib157","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102838_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156158","article-title":"An endophenotype network strategy uncovers YangXue QingNao Wan suppresses A\u03b2 deposition, improves mitochondrial dysfunction and glucose metabolism","volume":"135","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib159","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2013.07.007","article-title":"L-type Ca2+ currents at CA1 synapses\uff0c but not CA3 or dentate granule neuron synapses\uff0care increased in 3xtgad mice in an age-dependent manner","volume":"35","author":"Wang","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/metabo13010014","article-title":"HIIT ameliorates inflammation and lipid metabolism by regulating macrophage polarization and mitochondrial dynamics in the liver of type 2 diabetes mellitus mice","volume":"13","author":"Wang","year":"2022","journal-title":"Metabolites"},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib161","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1039\/C7FO01815K","article-title":"A comparative study of eicosapentaenoic acid enriched phosphatidylcholine and ethyl ester in improving cognitive deficiency in Alzheimer's disease model rats","volume":"9","author":"Wen","year":"2018","journal-title":"Food Funct."},{"issue":"13","key":"10.1016\/j.arr.2025.102838_bib162","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3390\/cells11132091","article-title":"Microglia phenotypes in aging and neurodegenerative diseases","volume":"11","author":"Wendimu","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.arr.2025.102838_bib163","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s42255-019-0126-8","article-title":"Voltage-energized calcium-sensitive ATP production by mitochondria","volume":"1","author":"Wescott","year":"2019","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib164","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519893859","article-title":"Protective effects of Huang-Lian-Jie-Du-Tang against A\u03b225-35-induced memory deficits and oxidative stress in rats","volume":"48","author":"Wu","year":"2020","journal-title":"J. Int. Med. Res."},{"issue":"8","key":"10.1016\/j.arr.2025.102838_bib165","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"issue":"39","key":"10.1016\/j.arr.2025.102838_bib166","doi-asserted-by":"crossref","first-page":"11554","DOI":"10.1021\/acs.jafc.1c04049","article-title":"Neuroprotective potential of mung bean (Vigna radiata L.) polyphenols in Alzheimer's disease: a review","volume":"69","author":"Xu","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib167","first-page":"309","article-title":"Effect of electroacupuncture on the ultrastructure of hippocampal CA1 region in transgenic Alzheimer's disease mice","volume":"34","author":"Xue","year":"2009","journal-title":"Acupunct. Res."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib168","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101204R","article-title":"Larger improvements in fatigue resistance and mitochondrial function with high-than with low-intensity contractions during interval training of mouse skeletal muscle","volume":"35","author":"Yamada","year":"2021","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2220\/biomedres.36.1","article-title":"Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic glutamate receptors in the hippocampus","volume":"36","author":"Yamazaki","year":"2015","journal-title":"Biomed. Res."},{"issue":"5","key":"10.1016\/j.arr.2025.102838_bib170","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.7150\/thno.70756","article-title":"Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model","volume":"12","author":"Yang","year":"2022","journal-title":"Theranostics"},{"issue":"Pt2","key":"10.1016\/j.arr.2025.102838_bib171","article-title":"A\u03b2-binding with alcohol dehydrogenase drives Alzheimer's disease pathogenesis: a review","volume":"264","author":"Ye","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102838_bib172","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1430599","article-title":"Melatonin modulates TLR4\/MyD88\/NF-\u03baB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats","volume":"15","author":"Yin","year":"2024","journal-title":"Front. Pharm."},{"issue":"4","key":"10.1016\/j.arr.2025.102838_bib173","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12264-015-1544-6","article-title":"Regulation of mitophagy in ischemic brain injury","volume":"31","author":"Yuan","year":"2015","journal-title":"Neurosci. Bull."},{"issue":"6","key":"10.1016\/j.arr.2025.102838_bib174","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.3390\/ijms24065785","article-title":"The Drp1-mediated mitochondrial fission protein interactome as an emerging core player in mitochondrial dynamics and cardiovascular disease therapy","volume":"24","author":"Zerihun","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.arr.2025.102838_bib175","article-title":"Nano-brake halts mitochondrial dysfunction cascade to alleviate neuropathology and rescue Alzheimer's cognitive deficits","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib176","doi-asserted-by":"crossref","DOI":"10.1063\/5.0013178","article-title":"Microglia-targeting nanotherapeutics for neurodegenerative diseases","volume":"4","author":"Zhao","year":"2020","journal-title":"APL Bioeng."},{"issue":"11","key":"10.1016\/j.arr.2025.102838_bib177","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.tibs.2020.06.004","article-title":"Molecular mechanisms of lysosome and nucleus communication","volume":"45","author":"Zhao","year":"2020","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib178","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-021-02101-6","article-title":"Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination","volume":"18","author":"Zheng","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"31","key":"10.1016\/j.arr.2025.102838_bib179","article-title":"Cordycepin modulates microglial M2 polarization coupled with mitochondrial metabolic reprogramming by targeting HKII and PDK2","volume":"11","author":"Zhong","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.arr.2025.102838_bib180","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jnutbio.2018.05.009","article-title":"Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet","volume":"59","author":"Zhou","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"04","key":"10.1016\/j.arr.2025.102838_bib181","first-page":"235","article-title":"Effects of moxibustion on the level of autophagy and learning and memory ability in Alzheimer's disease transgenic mice","volume":"44","author":"Zhu","year":"2019","journal-title":"Acupunct. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102838_bib182","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41401-021-00635-2","article-title":"Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP\/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis","volume":"43","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sin."},{"issue":"3","key":"10.1016\/j.arr.2025.102838_bib183","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12020-018-1575-7","article-title":"Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from high glucose-induced apoptosis","volume":"60","author":"Zou","year":"2018","journal-title":"Endocrine"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725001849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T21:12:54Z","timestamp":1759612374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725001849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":183,"alternative-id":["S1568163725001849"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102838","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The evolution of Alzheimer\u2019s disease: From mitochondria to microglia","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102838"}}