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Drug Delivery of Memantine with Carbon Dots for Alzheimer\u2019s Disease: Blood-1 Brain Barrier Penetration and Inhibition of Tau Aggregation 2 3. \u3008https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/\u3009."},{"issue":"1","key":"10.1016\/j.arr.2025.102851_bib164","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1038\/s41467-023-42505-x","article-title":"Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating Transgelin-2 in Alzheimer\u2019s disease","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102851_bib165","article-title":"Effects and mechanisms of polygonati rhizoma polysaccharide on potassium oxonate and Hypoxanthine-Induced hyperuricemia in mice","volume":"280","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. 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