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Neurosci."},{"key":"10.1016\/j.arr.2025.102866_bib90","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/jcbfm.2012.88","article-title":"Inflammatory cytokines in experimental and human stroke","volume":"32","author":"Lambertsen","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.arr.2025.102866_bib91","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161703","article-title":"Revisiting regulatory t cells for stroke therapy","volume":"132","author":"Lee","year":"2022","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2025.102866_bib92","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/s41598-017-01769-2","article-title":"Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102866_bib93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12974-020-02057-z","article-title":"The immune response of t cells and therapeutic targets related to regulating the levels of t helper cells after ischaemic stroke","volume":"18","author":"Lei","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2025.102866_bib94","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41593-024-01695-3","article-title":"Central nervous system-associated macrophages modulate the immune response following stroke in aged mice","volume":"27","author":"Levard","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102866_bib95","article-title":"Macrophage-Disguised manganese dioxide nanoparticles for neuroprotection by reducing oxidative stress and modulating inflammatory microenvironment in acute ischemic stroke","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.arr.2025.102866_bib96","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s12035-021-02635-z","article-title":"Neutrophil extracellular traps exacerbate ischemic brain damage","volume":"59","author":"Li","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102866_bib97","article-title":"Comparison of traditional Chinese Medicine in the Long-Term secondary prevention for patients with ischemic stroke: a systematical analysis","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.arr.2025.102866_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116611","article-title":"Protective effects and mechanisms of yi qi huo xue fang in cerebral ischemic stroke based on network pharmacology and experimental verification","volume":"314","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2025.102866_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107335","article-title":"Astragaloside IV promotes microglia\/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPAR\u03b3 pathway after cerebral ischemia\/reperfusion injury in rats","volume":"92","author":"Li","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.arr.2025.102866_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115653","article-title":"Quercetin improves cerebral ischemia\/reperfusion injury by promoting microglia\/macrophages M2 polarization via regulating PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. 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Ethnopharmacol."},{"key":"10.1016\/j.arr.2025.102866_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119440","article-title":"Buyang huanwu decoction promotes gray and White matter remyelination by inhibiting notch signaling activation in the astrocyte and microglia after ischemic stroke","volume":"343","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2025.102866_bib106","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ana.23815","article-title":"Adoptive regulatory T-cell therapy protects against cerebral ischemia","volume":"74","author":"Li","year":"2013","journal-title":"Ann. 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Immunol. Res."},{"key":"10.1016\/j.arr.2025.102866_bib113","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.7150\/thno.68895","article-title":"M2 microglia-derived extracellular vesicles promote White matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2025.102866_bib114","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhizaburge (Danshen): a golden herbal Medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharm. 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Pharm."},{"key":"10.1016\/j.arr.2025.102866_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101644","article-title":"A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: role of Akt(Ser473)\/GSK3\u03b2(Ser9)-mediated Nrf2 activation","volume":"36","author":"Liao","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2025.102866_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115968","article-title":"Acteoside alleviates blood-brain barrier damage induced by ischemic stroke through inhibiting microglia HMGB1\/TLR4\/NLRP3 signaling","volume":"220","author":"Liao","year":"2024","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.arr.2025.102866_bib122","doi-asserted-by":"crossref","first-page":"17350","DOI":"10.1523\/JNEUROSCI.4901-12.2013","article-title":"Boosting regulatory t cells limits neuroinflammation in permanent cortical stroke","volume":"33","author":"Liesz","year":"2013","journal-title":"J. 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Pharm. Sci."},{"key":"10.1016\/j.arr.2025.102866_bib264","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11596-025-00003-9","article-title":"The role of casr Inhibition-Mediated M2 microglial transformation in ischemic preconditioning against stroke","volume":"45","author":"Zhai","year":"2025","journal-title":"Curr. Med Sci."},{"key":"10.1016\/j.arr.2025.102866_bib265","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.phymed.2018.04.004","article-title":"Identifying quality-markers from shengmai san protects against transgenic mouse model of alzheimer's disease using chinmedomics approach","volume":"45","author":"Zhang","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arr.2025.102866_bib266","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1248\/bpb.b19-00847","article-title":"Protective effect of Tong-Qiao-Huo-Xue decoction on inflammatory injury caused by intestinal microbial disorders in stroke rats","volume":"43","author":"Zhang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.arr.2025.102866_bib267","article-title":"OIP5-AS1 inhibits oxidative stress and inflammation in ischemic stroke through miR-155-5p\/IRF2BP2 axis","volume":"48","author":"Zhang","year":"2023","journal-title":"Neurochem. 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