{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:55:55Z","timestamp":1792180555938,"version":"4.4.0"},"reference-count":378,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.arr.2025.102879","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:59:09Z","timestamp":1756137549000},"page":"102879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Biomolecular phase separation of microtubule-associated protein tau and its role in the genesis of brain disorders"],"prefix":"10.1016","volume":"113","author":[{"given":"Aurgha Kamal","family":"Bhandari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9970-0318","authenticated-orcid":false,"given":"Aman Singh","family":"Dhami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi Thanvanthan","family":"Hemanthkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beula","family":"Joslyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhujit","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaisri","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash Prasad","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-6539","authenticated-orcid":false,"given":"Karunakar","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7339-6657","authenticated-orcid":false,"given":"Bibin Gnanadhason","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2025.102879_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-05920-4","article-title":"Phosphorylation regulates tau\u2019s phase separation behavior and interactions with chromatin","volume":"7","author":"Abasi","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2022.08.132","article-title":"Aberrant liquid-liquid phase separation and amyloid aggregation of proteins related to neurodegenerative diseases","author":"Ahmad","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102879_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/alz.12432","article-title":"Dementia in Africa: current evidence, knowledge gaps, and future directions","volume":"18","author":"Akinyemi","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2025.102879_bib4","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.200295","article-title":"The wisdom of crowds: regulating cell function through condensed states of living matter","author":"Alberti","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2025.102879_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-genet-112618-043527","article-title":"Liquid-liquid phase separation in disease","volume":"53","author":"Alberti","year":"2019","journal-title":"Annu. Rev. Genet"},{"key":"10.1016\/j.arr.2025.102879_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2018.06.038","article-title":"A user\u2019s guide for phase separation assays with purified proteins","volume":"430","author":"Alberti","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.988074","article-title":"Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)","volume":"16","author":"Al-Hilaly","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib9","doi-asserted-by":"crossref","first-page":"34873","DOI":"10.1074\/jbc.M405131200","article-title":"Promotion of hyperphosphorylation by frontotemporal dementia tau mutations","volume":"279","author":"Alonso","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib10","first-page":"1","volume":"11","author":"Alquezar","year":"2021","journal-title":"Tau Post-Transl. Modif.: Dyn. Transform. Tau Funct., Degrad., Aggreg."},{"key":"10.1016\/j.arr.2025.102879_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00480-0","article-title":"Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau","volume":"8","author":"Ambadipudi","year":"2017","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.arr.2025.102879_bib12","first-page":"1","article-title":"Liquid\u2013liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau","volume":"81","author":"Ambadipudi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nmat2942","article-title":"A highly parallel method for synthesizing DNA repeats enables the discovery of \u2018smart\u2019 protein polymers","volume":"10","author":"Amiram","year":"2011","journal-title":"Nat. Mater."},{"key":"10.1016\/j.arr.2025.102879_bib14","first-page":"506","article-title":"Significance of native PLGA nanoparticles in the treatment of Alzheimer\u2019s disease pathology","volume":"17","author":"Anand","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2025.102879_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbrc.2018.04.198","article-title":"A\u03b21-40 mediated aggregation of proteins and metabolites unveils the relevance of amyloid cross-seeding in amyloidogenesis","volume":"501","author":"Anand","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib16","first-page":"4491","article-title":"Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress \u03b2-amyloid aggregation and neuronal toxicity","volume":"6","author":"Anand","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2025.102879_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pneurobio.2003.09.007","article-title":"Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the \u2018Dr. Jekyll and Mr. Hyde concept\u2019 of Alzheimer\u2019s disease or the yin and yang of neuroplasticity","volume":"71","author":"Arendt","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2025.102879_bib18","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.54.9.1787","article-title":"Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene","volume":"54","author":"Arima","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2025.102879_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/alz.12192","article-title":"Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer\u2019s disease","volume":"17","author":"Arnsten","year":"2020","journal-title":"Alzheimer\u2019S. Dement"},{"key":"10.1016\/j.arr.2025.102879_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09335-x","article-title":"Lithium deficiency and the onset of Alzheimer\u2019s disease","author":"Aron","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib21","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.tibs.2020.04.006","article-title":"The wide world of coacervates: from the sea to neurodegeneration","volume":"45","author":"Astoricchio","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib22","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.jmb.2020.03.004","article-title":"Liquid-liquid phase separation and its mechanistic role in pathological protein aggregation","volume":"432","author":"Babinchak","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib23","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1074\/jbc.RA118.007222","article-title":"The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain","volume":"294","author":"Babinchak","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2011.06.135","article-title":"Single particle analysis of tau oligomer formation induced by metal ions and organic solvents","volume":"411","author":"Bader","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature13999","article-title":"Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch","volume":"519","author":"Bah","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib26","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3390\/biom10111546","article-title":"Compounds from natural sources as protein kinase inhibitors","volume":"10","author":"Baier","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102879_bib27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00401-013-1188-4","article-title":"LRRK2 phosphorylates novel tau epitopes and promotes tauopathy","volume":"126","author":"Bailey","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.arr.2025.102879_bib28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-021-00732-z","article-title":"Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer\u2019s disease","author":"Balmik","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102879_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.06.010","article-title":"Compositional control of phase-separated cellular bodies","volume":"166","author":"Banani","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/anie.201703191","article-title":"Reentrant phase transition drives dynamic substructure formation in ribonucleoprotein droplets","volume":"56","author":"Banerjee","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.arr.2025.102879_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00204","article-title":"Role of tau as a microtubule-associated protein: structural and functional aspects","author":"Barbier","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib33","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41374-018-0166-9","article-title":"Spectrum of tau pathologies in huntington\u2019s disease","volume":"99","author":"Baskota","year":"2018","journal-title":"Lab. Invest"},{"key":"10.1016\/j.arr.2025.102879_bib34","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6633\/aaa61e","article-title":"Physical principles of intracellular organization via active and passive phase transitions","author":"Berry","year":"2018","journal-title":"Rep. Prog. Phys."},{"key":"10.1016\/j.arr.2025.102879_bib35","doi-asserted-by":"crossref","DOI":"10.1261\/rna.078999.121","article-title":"RNA multimerization as an organizing force for liquid\u2013liquid phase separation","volume":"28","author":"Bevilacqua","year":"2022","journal-title":"RNA"},{"key":"10.1016\/j.arr.2025.102879_bib36","doi-asserted-by":"crossref","DOI":"10.3791\/51997-v","article-title":"In vitro methylation assay to study protein arginine methylation","author":"Bikkavilli","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.arr.2025.102879_bib37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbadis.2004.08.014","article-title":"Tau, tangles, and Alzheimer\u2019s disease","volume":"1739","author":"Binder","year":"2005","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2025.102879_bib38","article-title":"\u201cMissing\u201d tau mutation identified","author":"Binkofski","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/122.4.741","article-title":"A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)","volume":"122","author":"Bird","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102879_bib40","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/jnr.21006","article-title":"Inhibition of proteasome and shaggy\/glycogen synthase kinase-3\u03b2 kinase prevents clearance of phosphorylated tau in Drosophila","volume":"84","author":"Blard","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2025.102879_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/archneur.65.4.460","article-title":"Refining FTDP-17 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)","volume":"65","author":"Boeve","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib42","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1073\/pnas.1821038116","article-title":"Spontaneous driving forces give rise to protein\u2212RNA condensates with coexisting phases and complex material properties","volume":"116","author":"Boeynaems","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.167971","article-title":"Phase separation in biology and disease; current perspectives and open questions","author":"Boeynaems","year":"2023","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.702788","article-title":"Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration","author":"Boyarko","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib45","unstructured":"Boyko, S., 2023. LIQUID-LIQUID PHASE SEPARATIO OF PATHOLOGICAL AGGRE by SOLOMIIA BOY N AS A MODULATOR GATION OF TAU KO."},{"key":"10.1016\/j.arr.2025.102879_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104722","article-title":"Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein","volume":"299","author":"Boyko","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib47","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1074\/jbc.AC119.009198","article-title":"Liquid-liquid phase separation of tau protein: the crucial role of electrostatic interactions","volume":"294","author":"Boyko","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib48","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2012460117","article-title":"Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation","volume":"117","author":"Boyko","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbadis.2004.06.018","article-title":"Tau alteration and neuronal degeneration in tauopathies: mechanisms and models","volume":"1739","author":"Brandt","year":"2005","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2025.102879_bib52","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.1172046","article-title":"Germline P granules are liquid droplets that localize by controlled dissolution\/condensation","volume":"324","author":"Brangwynne","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102879_bib53","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1073\/pnas.1017150108","article-title":"Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes","volume":"108","author":"Brangwynne","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib54","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1289\/ehp.7567","article-title":"Neurodegenerative diseases: an overview of environmental risk factors","volume":"113","author":"Brown","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.arr.2025.102879_bib55","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.phrs.2010.12.002","article-title":"The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer\u2019s disease and related tauopathies","volume":"63","author":"Brunden","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2025.102879_bib56","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-019-03349-1","article-title":"Mechanisms of secretion and spreading of pathological tau protein","author":"Brunello","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102879_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/ene.15603","article-title":"The many faces of globular glial tauopathy: a clinical and imaging study","volume":"30","author":"Buciuc","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.2008.05692.x","article-title":"Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps","volume":"107","author":"Chang","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2025.102879_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100937","article-title":"Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism","volume":"56","author":"Chaudhuri","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41422-020-00408-2","article-title":"Liquid\u2013liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA","author":"Chen","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.arr.2025.102879_bib61","article-title":"Screening membraneless organelle participants with machine-learning models that integrate multimodal features","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib62","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/794089","article-title":"Regulation and function of protein kinases and phosphatases","volume":"2011","author":"Cheng","year":"2011","journal-title":"Enzym. Res."},{"key":"10.1016\/j.arr.2025.102879_bib63","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/pro.2141","article-title":"Influence of temperature on formation of perfect tau fragment fibrils using PRIME20 \/ DMD simulations","volume":"21","author":"Cheon","year":"2012","journal-title":"Protien Sci."},{"key":"10.1016\/j.arr.2025.102879_bib64","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-biophys-121219-081629","article-title":"Physical principles underlying the complex biology of intracellular phase transitions","author":"Choi","year":"2020","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.arr.2025.102879_bib65","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1016\/j.jmb.2018.06.014","article-title":"RGG\/RG Motif Regions in RNA binding and phase separation","volume":"430","author":"Chong","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.95.22.13103","article-title":"Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17","volume":"95","author":"Clark","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","author":"Congdon","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/ana.410410222","article-title":"Genetic evidence for the involvement of \u03c4 in progressive supranuclear palsy","volume":"41","author":"Conrad","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib69","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-018-1911-2","article-title":"Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau","volume":"136","author":"Courade","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib70","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib71","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13195-023-01321-7","article-title":"The therapeutic landscape of tauopathies: challenges and prospects","volume":"15","author":"Cummings","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib72","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.96.10.5598","article-title":"Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements","volume":"96","author":"D\u2019Souza","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2015.03.008","article-title":"Relating sequence encoded information to form and function of intrinsically disordered proteins","author":"Das","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0022-510X(86)90167-X","article-title":"Alzheimer\u2019s disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments","volume":"76","author":"Delacourte","year":"1986","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib75","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0925-4439(93)90023-T","article-title":"Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzhemier\u2019s disease. BBA - Mol","volume":"1181","author":"Demaerschalck","year":"1993","journal-title":"Basis Dis."},{"key":"10.1016\/j.arr.2025.102879_bib76","doi-asserted-by":"crossref","DOI":"10.1007\/s44307-024-00020-0","article-title":"Technologies for studying phase-separated biomolecular condensates","volume":"2","author":"Deng","year":"2024","journal-title":"Adv. Biotechnol."},{"key":"10.1016\/j.arr.2025.102879_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.12621","article-title":"Microtubules in neurons as information carriers","author":"Dent","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2025.102879_bib78","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/s41419-021-04240-3","article-title":"A long way to go: caspase inhibitors in clinical use","volume":"12","author":"Dhani","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2025.102879_bib79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-physchem-071819-113553","article-title":"Biomolecular phase separation: from molecular driving forces to macroscopic properties","volume":"71","author":"Dignon","year":"2020","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib80","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.242720499","article-title":"Chaperones increase association of tau protein with microtubules","volume":"100","author":"Dou","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib81","article-title":"Inhibitory act of selenoprotein P on Cu+\/Cu2+-induced tau aggregation and neurotoxicity","volume":"53","author":"Du","year":"2014","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41422-019-0141-z","article-title":"PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins","volume":"29","author":"Duan","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.arr.2025.102879_bib83","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.1021\/bi501333q","article-title":"Evidence of rapid coaggregation of globular proteins during amyloid formation","volume":"53","author":"Dubey","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00163","article-title":"Recruitment, retainment, and biomarkers of response; a pilot trial of lithium in humans with mild cognitive impairment","volume":"12","author":"Duthie","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abo4459","article-title":"Microtubule-binding core of the tau protein","volume":"8","author":"El Mammeri","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2025.102879_bib86","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.1074\/jbc.REV118.001188","article-title":"Matter over mind: Liquid phase separation and neurodegeneration","volume":"294","author":"Elbaum-Garfinkle","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib87","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1504822112","article-title":"The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics","volume":"112","author":"Elbaum-Garfinkle","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib88","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1073\/pnas.1615395114","article-title":"Independent active and thermodynamic processes govern the nucleolus assembly in vivo","volume":"114","author":"Falahati","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders","author":"Falkenberg","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2025.102879_bib90","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800054","article-title":"Regulation of microtubule dynamic instability by the carboxy-terminal tail of \u03b2-tubulin","volume":"1","author":"Fees","year":"2018","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.arr.2025.102879_bib91","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1242\/jcs.01655","article-title":"Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4\/p38\u03b4 at Thr50 promotes microtubule assembly","volume":"118","author":"Feijoo","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.arr.2025.102879_bib92","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00015.2020","article-title":"The complexity of Alzheimer\u2019s disease: an evolving puzzle","volume":"101","author":"Ferrari","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib93","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3389\/fneur.2019.00713","article-title":"Chronic traumatic encephalopathy: a brief overview","volume":"10","author":"Fesharaki-Zadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib94","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-020-18405-9","article-title":"Pre-symptomatic caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging","volume":"11","author":"Flores","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib95","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1093\/brain\/awad024","article-title":"Tilavonemab in early Alzheimer\u2019s disease: results from a phase 2, randomized, double-blind study","volume":"146","author":"Florian","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102879_bib96","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s00018-015-1839-9","article-title":"Cellular factors modulating the mechanism of tau protein aggregation","volume":"72","author":"Fontaine","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102879_bib97","doi-asserted-by":"crossref","unstructured":"Fontaine, Sarah N., Sabbagh, J.J., Baker, J., 2015. Cellular factors modulating the mechanism of tau protein aggregation 1863\u20131879. https:\/\/doi.org\/10.1007\/s00018-015-1839-9.","DOI":"10.1007\/s00018-015-1839-9"},{"key":"10.1016\/j.arr.2025.102879_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2007.03.003","article-title":"Functional amyloid - from bacteria to humans","author":"Fowler","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib99","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.TM118.001190","article-title":"Prion-like low-complexity sequences: key regulators of protein solubility and phase behavior","author":"Franzmann","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib100","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","article-title":"Propagation of Tau misfolding from the outside to the inside of a cell","volume":"284","author":"Frost","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib101","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00109-023-02407-3","article-title":"Liquid \u2013 liquid phase separation in Alzheimer \u2019 s disease","volume":"1","author":"Fu","year":"2024","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.arr.2025.102879_bib102","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3233\/JAD-2010-100687","article-title":"LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3\u03b2 in vivo and in vitro","volume":"21","author":"Fu","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2025.102879_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2019.06.077","article-title":"P1-052: a single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the anti-phospho-tau antibody JNJ-63733657 in healthy subjects","volume":"15","author":"Galpern","year":"2019","journal-title":"Alzheimer\u2019S. Dement"},{"key":"10.1016\/j.arr.2025.102879_bib104","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-018-0237-7","article-title":"Converging pathways in neurodegeneration, from genetics to mechanisms","author":"Gan","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.599384","article-title":"Tauopathy and movement disorders\u2014unveiling the chameleons and mimics","author":"Ganguly","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib106","doi-asserted-by":"crossref","first-page":"175","DOI":"10.21037\/atm.2018.04.23","article-title":"Tau in neurodegenerative disease","volume":"6","author":"Gao","year":"2018","journal-title":"Ann. Transl. Med."},{"issue":"9","key":"10.1016\/j.arr.2025.102879_bib107","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","article-title":"Alzheimer disease therapy\u2014moving from amyloid-\u03b2 to tau","volume":"912","author":"Giacobini","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib108","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib109","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-32-9358-8_1","article-title":"Ordered assembly of tau protein and neurodegeneration","author":"Goedert","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib110","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.TM118.001192","article-title":"The molecular language of membraneless organelles","author":"Gomes","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib111","first-page":"233","article-title":"Neuropathology of Alzheimer\u2019s Disease","author":"Gomez-isla","year":"2008","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib112","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-023-00605-8","article-title":"Plasma phospho-tau in Alzheimer\u2019s disease: towards diagnostic and therapeutic trial applications","author":"Gonzalez-Ortiz","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib113","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M007489200","article-title":"Structural and functional differences between 3-repeat and 4-repeat tau isoforms: implications for normal tau function and the onset of neurodegenerative disease","volume":"275","author":"Goode","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib114","article-title":"Biomolecular condensates: structure, functions, methods of research","author":"Gorsheneva","year":"2024","journal-title":"Biochem"},{"key":"10.1016\/j.arr.2025.102879_bib115","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153632","article-title":"Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties","volume":"22","author":"Grese","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2025.102879_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-4886(03)00393-5","article-title":"A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy","volume":"184","author":"Grover","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib117","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108443","article-title":"Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation","volume":"41","author":"Gruijs da Silva","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2025.102879_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09902-7","article-title":"Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly","volume":"10","author":"Gui","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib119","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-017-1707-9","article-title":"Roles of tau protein in health and disease","author":"Guo","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2016.05.002","article-title":"A glass menagerie of low complexity sequences","author":"Halfmann","year":"2016","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib121","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2025.102879_bib122","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M901095200","article-title":"Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro","volume":"284","author":"Han","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib123","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2009.01.003","article-title":"Tau phosphorylation: the therapeutic challenge for neurodegenerative disease","volume":"15","author":"Hanger","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2025.102879_bib124","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30294","article-title":"Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins","volume":"6","author":"Harmon","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102879_bib125","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13195-025-01775-x","article-title":"Revisiting the therapeutic landscape of tauopathies: assessing the current pipeline and clinical trials","volume":"17","author":"Harris","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/frbis.2023.1208763","article-title":"Grand challenges in biomolecular condensates: structure, function, and formation","volume":"1","author":"Hatters","year":"2023","journal-title":"Front. Biophys."},{"key":"10.1016\/j.arr.2025.102879_bib127","doi-asserted-by":"crossref","DOI":"10.1002\/ana.10163","article-title":"Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation","volume":"51","author":"Hayashi","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.030","article-title":"RNA-mediated feedback control of transcriptional condensates","volume":"184","author":"Henninger","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2017.08.042","article-title":"Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase","volume":"20","author":"Hern\u00e1ndez-Vega","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2025.102879_bib130","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1021\/jacs.4c00256","article-title":"Maturation and conformational switching of a De novo designed phase-separating polypeptide","volume":"146","author":"Hilditch","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.arr.2025.102879_bib131","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pharmthera.2012.07.001","article-title":"Tau as a therapeutic target in neurodegenerative disease","volume":"136","author":"Himmelstein","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib132","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.3390\/molecules23092335","article-title":"Novel protein kinase inhibitors related to tau pathology modulate tau protein-self interaction using a luciferase complementation assay","volume":"23","author":"Holzer","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102879_bib133","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/13543784.2019.1619694","article-title":"Tau immunotherapies for Alzheimer\u2019s disease","volume":"28","author":"Hoskin","year":"2019","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"15","key":"10.1016\/j.arr.2025.102879_bib134","first-page":"1","article-title":"Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions","volume":"151","author":"Hou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib135","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jamaneurol.2019.3762","article-title":"Minocycline at 2 different dosages vs placebo for patients with mild Alzheimer disease: a randomized clinical trial","volume":"77","author":"Howard","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00311","article-title":"Expression of tau pathology-related proteins in different brain regions: a molecular basis of tau pathogenesis","volume":"9","author":"Hu","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib137","doi-asserted-by":"crossref","DOI":"10.1002\/ana.20969","article-title":"Characteristics of frontotemporal dementia patients with a Progranulin mutation","volume":"60","author":"Huey","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib138","doi-asserted-by":"crossref","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2019-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in Alzheimer disease and other tauopathies","author":"Iqbal","year":"2005","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.arr.2025.102879_bib140","doi-asserted-by":"crossref","DOI":"10.2174\/156720510793611592","article-title":"Tau in Alzheimer disease and related tauopathies","volume":"7","author":"Iqbal","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.arr.2025.102879_bib141","doi-asserted-by":"crossref","DOI":"10.1007\/s004010000333","article-title":"Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells","volume":"102","author":"Iseki","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.11.041","article-title":"Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid","volume":"80","author":"Iserman","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib143","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bpj.2016.10.043","article-title":"Phase transitions in biological systems with many components","volume":"112","author":"Jacobs","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.arr.2025.102879_bib144","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-019-0664-z","article-title":"A walk through tau therapeutic strategies","volume":"7","author":"Jadhav","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib145","doi-asserted-by":"crossref","DOI":"10.1038\/nature22386","article-title":"RNA phase transitions in repeat expansion disorders","volume":"546","author":"Jain","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib146","doi-asserted-by":"crossref","DOI":"10.1097\/NEN.0000000000000013","article-title":"Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease","volume":"72","author":"Jarero-Basulto","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib147","doi-asserted-by":"crossref","DOI":"10.1021\/bi800783d","article-title":"The natively unfolded character of Tau and its aggregation to Alzheimer-like paired helical filaments","volume":"47","author":"Jeganathan","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib148","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00702-009-0240-y","article-title":"Recent advances in our understanding of neurodegeneration","volume":"116","author":"Jellinger","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.arr.2025.102879_bib149","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.arr.2025.102879_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2013.02.007","article-title":"Describing intrinsically disordered proteins at atomic resolution by NMR","author":"Jensen","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib151","article-title":"Zn2+ Interrupts R4-R3 Association Leading to Accelerated Aggregation of Tau Protein. Chem. - A Eur. J","volume":"23","author":"Jiji","year":"2017"},{"key":"10.1016\/j.arr.2025.102879_bib152","doi-asserted-by":"crossref","DOI":"10.1038\/nrneurol.2013.33","article-title":"The clinical spectrum of sport-related traumatic brain injury","author":"Jordan","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib153","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.arr.2025.102879_bib154","first-page":"1","article-title":"Liquid-liquid phase separation induces pathogenic tau conformations in vitro","volume":"111","author":"Kanaan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib155","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16580-3","article-title":"Liquid-liquid phase separation induces pathogenic tau conformations in vitro","volume":"11","author":"Kanaan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib156","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jmb.2013.11.019","article-title":"D-polyglutamine amyloid recruits L-polyglutamine monomers and kills cells","volume":"426","author":"Kar","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib157","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/biom9020071","article-title":"Molecular crowding tunes material states of ribonucleoprotein condensates","volume":"9","author":"Kaur","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102879_bib158","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/pcn.13485","article-title":"Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment","volume":"76","author":"Kawakami","year":"2022","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101924","article-title":"Nature\u2019s toolbox against tau aggregation: an updated review of current research","volume":"87","author":"Khan","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib160","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer\u2019s disease with pittsburgh compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib161","article-title":"The amyloid state and its association with protein misfolding diseases","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2025.102879_bib162","doi-asserted-by":"crossref","DOI":"10.1002\/ana.10447","article-title":"A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology","volume":"53","author":"Kobayashi","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib163","article-title":"First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer\u2019s disease model","volume":"6","author":"Kontsekova","year":"2014","journal-title":"Alzheimer\u2019S. Res. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib164","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molcel.2018.10.009","article-title":"Liquid and hydrogel phases of PrPC linked to conformation shifts and triggered by Alzheimer\u2019s amyloid-\u03b2 oligomers","volume":"72","author":"Kostylev","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib165","doi-asserted-by":"crossref","DOI":"10.3390\/neuroglia1020023","article-title":"Understanding the relevance of aging-related tau astrogliopathy (ARTAG)","volume":"1","author":"Kovacs","year":"2018","journal-title":"Neuroglia"},{"key":"10.1016\/j.arr.2025.102879_bib166","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib167","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06807","article-title":"Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules","volume":"4","author":"Kroschwald","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102879_bib168","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M114.554725","article-title":"Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity","volume":"289","author":"Kumar","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib169","doi-asserted-by":"crossref","unstructured":"Kundel, F., De, S., Flagmeier, P., Horrocks, M.H., Kjaergaard, M., Shammas, S.L., Jackson, S.E., Dobson, C.M., Klenerman, D., 2018. Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity. https:\/\/doi.org\/10.1021\/acschembio.7b01039.","DOI":"10.1021\/acschembio.7b01039"},{"key":"10.1016\/j.arr.2025.102879_bib170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms151223090","article-title":"What macromolecular crowding can do to a protein","author":"Kuznetsova","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/molecules20011377","article-title":"Beyond the excluded volume effects: Mechanistic complexity of the crowded milieu","author":"Kuznetsova","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102879_bib172","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s00415-024-12314-3","article-title":"Genetic forms of tauopathies: inherited causes and implications of Alzheimer\u2019s disease-like TAU pathology in primary and secondary tauopathies","volume":"271","author":"Langerscheidt","year":"2024","journal-title":"J. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib173","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201701010","article-title":"Microstructured elastomer-PEG hydrogels via kinetic capture of aqueous liquid\u2013liquid phase separation","volume":"5","author":"Lau","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib174","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1074\/jbc.AC117.001037","article-title":"TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues","volume":"293","author":"Li","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib175","doi-asserted-by":"crossref","DOI":"10.1038\/nature10879","article-title":"Phase transitions in the assembly of multivalent signalling proteins","volume":"483","author":"Li","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106167","article-title":"Liquid \u2212 liquid phase separation of tau: driving forces, regulation, and biological implications","author":"Li","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2025.102879_bib177","doi-asserted-by":"crossref","first-page":"D320","DOI":"10.1093\/nar\/gkz778","article-title":"LLPSDB: a database of proteins undergoing liquid-liquid phase separation in vitro","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arr.2025.102879_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127841","article-title":"Structural insights into the co-aggregation of A\u03b2 and tau amyloid core peptides: revealing potential pathological heterooligomers by simulations","volume":"254","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102879_bib179","doi-asserted-by":"crossref","first-page":"37061","DOI":"10.1074\/jbc.M403672200","article-title":"Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection","volume":"279","author":"Liao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.molcel.2015.08.018","article-title":"Formation and maturation of phase-separated liquid droplets by RNA-binding proteins","volume":"60","author":"Lin","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib181","doi-asserted-by":"crossref","first-page":"19110","DOI":"10.1074\/jbc.M117.800466","article-title":"Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs","volume":"292","author":"Lin","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib182","doi-asserted-by":"crossref","first-page":"10804","DOI":"10.1073\/pnas.0400348101","article-title":"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer\u2019s disease","volume":"101","author":"Liu","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib183","doi-asserted-by":"crossref","first-page":"10968","DOI":"10.1039\/C9CP06954B","article-title":"The misfolding mechanism of the key fragment R3 of tau protein: a combined molecular dynamics simulation and Markov state model study","volume":"22","author":"Liu","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.arr.2025.102879_bib184","author":"Liu","year":"2021","journal-title":"Crit. Phenom. Liq. -Liq. Phase Sep. Biomol. Condens."},{"issue":"22","key":"10.1016\/j.arr.2025.102879_bib185","first-page":"1","article-title":"Crosstalk between protein post-translational modifications and phase separation","volume":"221","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102879_bib186","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1417548111","article-title":"SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination","volume":"111","author":"Luo","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2013.03.040","article-title":"Structural and hydrodynamic analysis of a novel drug delivery vector: ELP[V5G3A2-150","volume":"104","author":"Lyons","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.arr.2025.102879_bib188","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/acscentsci.9b00087","article-title":"Designing electrostatic interactions via polyelectrolyte monomer sequence","volume":"5","author":"Lytle","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib189","doi-asserted-by":"crossref","DOI":"10.1002\/bip.20335","article-title":"Binding of copper (II) ion to an Alzheimer\u2019s tau peptide as revealed by MALDI-TOF MS, CD, and NMR","volume":"79","author":"Ma","year":"2005","journal-title":"Biopolymers"},{"key":"10.1016\/j.arr.2025.102879_bib190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.npep.2013.10.011","article-title":"Microtubule-stabilizing peptides and small molecules protecting axonal transport and brain function: focus on davunetide (NAP)","volume":"47","author":"Magen","year":"2013","journal-title":"Neuropeptides"},{"key":"10.1016\/j.arr.2025.102879_bib191","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.aar7366","article-title":"RNA buffers the phase separation behavior of prion-like RNA binding proteins","volume":"360","author":"Maharana","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102879_bib192","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4103\/1673-5374.380900","article-title":"Small molecules to target tau amyloid aggregation","volume":"19","author":"Manglano-Artu\u00f1edo","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2025.102879_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.01.048","article-title":"RNA binding antagonizes neurotoxic phase transitions of TDP-43","volume":"102","author":"Mann","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2025.102879_bib194","doi-asserted-by":"crossref","DOI":"10.1038\/nchem.2361","article-title":"O-GlcNAc modification blocks the aggregation and toxicity of the protein \u03b1-synuclein associated with Parkinson\u2019s disease","volume":"7","author":"Marotta","year":"2015","journal-title":"Nat. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib195","doi-asserted-by":"crossref","DOI":"10.1021\/acs.biochem.8b00008","article-title":"Relationship of sequence and phase separation in protein low-complexity regions","author":"Martin","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib196","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","article-title":"Tau protein kinases: Involvement in Alzheimer\u2019s disease","volume":"12","author":"Martin","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib197","doi-asserted-by":"crossref","DOI":"10.1038\/nrd2111","article-title":"Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases","author":"Mazanetz","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2025.102879_bib198","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of alzheimer\u2019s disease: Report of the NINCDS-ADRDA work group\u22c6 under the auspices of department of health and human services task force on alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.arr.2025.102879_bib199","article-title":"Implications of tau dysregulation in huntington\u2019s disease and potential for new therapeutics","volume":"12","author":"Mees","year":"2023","journal-title":"J. Huntingt. Dis."},{"key":"10.1016\/j.arr.2025.102879_bib200","doi-asserted-by":"crossref","DOI":"10.3390\/biom9030105","article-title":"Structure and functions of microtubule associated proteins tau and map2c: similarities and differences","author":"Melkov\u00e1","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102879_bib201","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2025.102879_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2007.01.009","article-title":"Atomic-level characterization of disordered protein ensembles","author":"Mittag","year":"2007","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib203","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National institute on aging-Alzheimer\u2019s association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2025.102879_bib205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003537","article-title":"Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases","volume":"9","author":"Morales","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.arr.2025.102879_bib206","doi-asserted-by":"crossref","DOI":"10.1093\/jnen\/nlad064","article-title":"Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy","volume":"82","author":"Morris","year":"2023","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib207","article-title":"Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy","author":"Morris","year":"2023","journal-title":"medRxiv"},{"key":"10.1016\/j.arr.2025.102879_bib208","doi-asserted-by":"crossref","DOI":"10.1002\/dneu.22774","article-title":"Tubulin post-translational modifications control neuronal development and functions","author":"Moutin","year":"2021","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.arr.2025.102879_bib209","first-page":"447","article-title":"Tau and its interactions with other proteins in neurodegenerative diseases","volume":"2","author":"Mroczek","year":"2020","journal-title":"Genet. Neurol. Behav. Diet. Park. Dis. Neurosci. Park. Dis. Vol."},{"key":"10.1016\/j.arr.2025.102879_bib210","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1039\/D3CS01065A","article-title":"Protein misfolding and amyloid nucleation through liquid-liquid phase separation","volume":"53","author":"Mukherjee","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib211","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1039\/D3CS01065A","article-title":"Protein misfolding and amyloid nucleation through liquid\u2013liquid phase separation","volume":"53","author":"Mukherjee","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib212","doi-asserted-by":"crossref","first-page":"24978","DOI":"10.1074\/jbc.M501565200","article-title":"Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions","volume":"280","author":"Mukrasch","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib213","article-title":"Biomolecular condensates pique drug discovery curiosity","author":"Mullard","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2025.102879_bib214","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-023-02326-3","article-title":"Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer\u2019s disease: a phase 1b, randomized, placebo-controlled trial","volume":"29","author":"Mummery","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2025.102879_bib215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124400","article-title":"Semisynthetic modification of tau protein with di-ubiquitin chains for aggregation studies","volume":"21","author":"Munari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib216","article-title":"VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation","volume":"12","author":"Mun\u00f5z-Braceras","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.arr.2025.102879_bib217","doi-asserted-by":"crossref","first-page":"E9782","DOI":"10.1073\/pnas.1806174115","article-title":"Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers","volume":"115","author":"Murray","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib218","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41594-019-0250-x","article-title":"Molecular interactions underlying liquid\u2212liquid phase separation of the FUS low-complexity domain","volume":"26","author":"Murthy","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib219","first-page":"1","article-title":"ll Review key physicochemical and biological factors of the phase behavior of tau","author":"Nam","year":"2020","journal-title":"Chempr"},{"key":"10.1016\/j.arr.2025.102879_bib220","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.chempr.2020.09.012","article-title":"Key physicochemical and biological factors of the phase behavior of tau","volume":"6","author":"Nam","year":"2020","journal-title":"Chem"},{"key":"10.1016\/j.arr.2025.102879_bib221","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190783","article-title":"Human tau pathology transmits glial tau aggregates in the absence of neuronal tau","volume":"217","author":"Narasimhan","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.arr.2025.102879_bib222","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2990.2005.00629.x","article-title":"A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects","volume":"31","author":"Neumann","year":"2005","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.arr.2025.102879_bib223","doi-asserted-by":"crossref","DOI":"10.1007\/s10048-005-0210-y","article-title":"Novel G335V mutation in the tau gene associated with early onset familial frontotemporal dementia","volume":"6","author":"Neumann","year":"2005","journal-title":"Neurogenetics"},{"key":"10.1016\/j.arr.2025.102879_bib224","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ajpath.2017.01.022","article-title":"Tau antibody targeting pathological species blocks neuronal uptake and interneuron propagation of tau in vitro","volume":"187","author":"Nobuhara","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.arr.2025.102879_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2015.01.013","article-title":"Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles","volume":"57","author":"Nott","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib226","series-title":"Advances in Protein Chemistry and Structural Biology","article-title":"Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases","author":"de Oliveira","year":"2019"},{"key":"10.1016\/j.arr.2025.102879_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2016.05.042","article-title":"Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein","volume":"63","author":"Pak","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib228","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101594","article-title":"APOE mediated neuroinflammation and neurodegeneration in Alzheimer\u2019s disease","volume":"59","author":"Parhizkar","year":"2022","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.arr.2025.102879_bib229","doi-asserted-by":"crossref","first-page":"405","DOI":"10.5483\/BMBRep.2016.49.8.084","article-title":"Tau mis-splicing in the pathogenesis of neurodegenerative disorders","volume":"49","author":"Park","year":"2016","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2025.102879_bib230","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib231","first-page":"233","article-title":"Guidelines for experimental characterization of liquid\u2013liquid phase separation in vitro","author":"Pattanashetty","year":"2023","journal-title":"Droplets Life Membr. Organe Biomol. Condens. Biol. Liq. Phase Sep."},{"key":"10.1016\/j.arr.2025.102879_bib232","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2019.09.007","article-title":"Molecular structure in biomolecular condensates","author":"Peran","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib233","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2016.07.005","article-title":"Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways","author":"Perluigi","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2025.102879_bib234","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1021\/acschemneuro.2c00057","article-title":"O-GlcNAcase inhibitor ASN90 is a multimodal drug candidate for tau and \u03b1-synuclein proteinopathies","volume":"13","author":"Permanne","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib235","first-page":"99","article-title":"Postconcussive syndrome","author":"Permenter","year":"2023","journal-title":"Sport. Concussion Diagn. Manag. Second Ed."},{"key":"10.1016\/j.arr.2025.102879_bib236","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/WNL.45.6.1062","article-title":"Familial progressive subcortical gliosis","volume":"45","author":"Petersen","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2025.102879_bib237","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awf069","article-title":"Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene","volume":"125","author":"Pickering-Brown","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102879_bib238","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1021\/bi0266176","article-title":"Polyproline type II conformation in the C-terminal domain of the nuclear pore complex protein gp210","volume":"42","author":"Pilpel","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib239","doi-asserted-by":"crossref","first-page":"69","DOI":"10.36255\/exonpublications.alzheimersdisease.2020.ch4","article-title":"Tau protein-targeted therapies in Alzheimer\u2019s disease: current state and future perspectives","author":"Pluta","year":"2020","journal-title":"Alzheimer\u2019S. Dis. Drug Discov."},{"key":"10.1016\/j.arr.2025.102879_bib240","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trsl.2022.10.009","article-title":"Targeting caspase-2 interactions with tau in Alzheimer\u2019s disease and related dementias","volume":"254","author":"Pockes","year":"2023","journal-title":"Transl. Res."},{"issue":"3","key":"10.1016\/j.arr.2025.102879_bib241","first-page":"1","article-title":"Parkinson disease","volume":"31","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2025.102879_bib242","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1016\/j.jmb.2020.05.027","article-title":"Paired helical filament-forming region of Tau (297\u2013391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells","volume":"432","author":"Pollack","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib243","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ana.10340","article-title":"An R5L \u03c4 mutation in a subject with a progressive supranuclear palsy phenotype","volume":"52","author":"Poorkaj","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib244","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.str.2019.09.003","article-title":"Insight into the Structure of the \u201cUnstructured\u201d Tau Protein","volume":"27","author":"Popov","year":"2019","journal-title":"Structure"},{"key":"10.1016\/j.arr.2025.102879_bib245","author":"Poschmann","year":"2010","journal-title":"Role Pept. prolyl isomerase Rrd1 Transcr. Stress Response"},{"key":"10.1016\/j.arr.2025.102879_bib246","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41594-019-0193-2","article-title":"A gel phase promotes condensation of liquid P granules in C. elegans embryos","volume":"26","author":"Putnam","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib247","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.cell.2018.03.056","article-title":"FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-\u03c0 interactions","volume":"173","author":"Qamar","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib248","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/pro.4093","article-title":"Liquid\u2013liquid phase separation of tau: from molecular biophysics to physiology and disease","volume":"30","author":"Rai","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.arr.2025.102879_bib249","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer\u2019s disease \u03b2-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib250","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1021\/acschemneuro.9b00455","article-title":"The Acetyl Mimicking Mutation, K274Q in Tau, Enhances the Metal Binding Affinity of Tau and Reduces the Ability of Tau to Protect DNA","volume":"11","author":"Rane","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib251","doi-asserted-by":"crossref","first-page":"E9569","DOI":"10.1073\/pnas.1712396114","article-title":"Numerous interactions act redundantly to assemble a tunable size of P bodies in Saccharomyces cerevisiae","volume":"114","author":"Rao","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib252","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26526","article-title":"The liquid structure of elastin","volume":"6","author":"Rauscher","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102879_bib253","doi-asserted-by":"crossref","first-page":"12841","DOI":"10.3390\/ijms232112841","article-title":"Phosphorylated tau in Alzheimer\u2019s disease and other tauopathies","volume":"23","author":"Rawat","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib254","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112841","article-title":"Phosphorylated tau in Alzheimer\u2019s disease and other tauopathies","author":"Rawat","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib255","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.357.6357.1250-j","article-title":"Phase separation and cellular organization","volume":"357","author":"Ray","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102879_bib256","doi-asserted-by":"crossref","DOI":"10.1038\/s41557-020-0465-9","article-title":"\u03b1-Synuclein aggregation nucleates through liquid\u2013liquid phase separation","volume":"12","author":"Ray","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib257","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202204311","article-title":"Phase separation of heterogeneous nuclear ribonucleoprotein A1 upon specific RNA-binding observed by magnetic resonance**","volume":"61","author":"Ritsch","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.arr.2025.102879_bib258","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00202","article-title":"Frontotemporal dementia-associated N279K tau mutation localizes at the nuclear compartment","volume":"12","author":"Ritter","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib259","doi-asserted-by":"crossref","DOI":"10.1086\/302256","article-title":"High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands","volume":"64","author":"Rizzu","year":"1999","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.arr.2025.102879_bib260","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-020-0884-2","article-title":"Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer\u2019s disease","volume":"8","author":"Roberts","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib261","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-2004-6505","article-title":"The potential role of tau protein O-glycosylation in Alzheimer\u2019s disease","volume":"6","author":"Robertson","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2025.102879_bib262","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-020-0264-6","article-title":"RNA contributions to the form and function of biomolecular condensates","author":"Roden","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2025.102879_bib263","doi-asserted-by":"crossref","DOI":"10.1590\/S1980-57642015DN91000002","article-title":"Argyrophilic grain disease: an underestimated tauopathy","volume":"9","author":"Rodriguez","year":"2015","journal-title":"Dement. Neuropsychol."},{"key":"10.1016\/j.arr.2025.102879_bib264","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2022.140885","article-title":"Modulation of \u03b1-synuclein phase separation by biomolecules","volume":"1871","author":"Rodr\u00edguez","year":"2023","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"10.1016\/j.arr.2025.102879_bib265","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.151053","article-title":"Liquid-liquid phase separation of tau and \u03b1-synuclein: a new pathway of overlapping neuropathologies","volume":"741","author":"Rodr\u00edguez","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib266","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.neurobiolaging.2013.03.015","article-title":"Tau phosphorylation affects its axonal transport and degradation","volume":"34","author":"Rodr\u00edguez-Mart\u00edn","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2025.102879_bib267","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s10495-010-0463-2","article-title":"The role of caspases in Alzheimer\u2019s disease; potential novel therapeutic opportunities","volume":"15","author":"Rohn","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.arr.2025.102879_bib268","doi-asserted-by":"crossref","DOI":"10.1001\/archneur.62.9.1444","article-title":"A new mutation of the \u03c4 gene, G303V, in early-onset familial progressive supranuclear palsy","volume":"62","author":"Ros","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib269","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00192","article-title":"Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutations","volume":"7","author":"Rossi","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib270","article-title":"Progressive supranuclear palsy and Parkinson\u2019s disease in a family with a new mutation in the tau gene","volume":"2","author":"Rossi","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib271","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: a review","volume":"11","author":"Rothblum-Oviatt","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.arr.2025.102879_bib272","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2018.06.031","article-title":"Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers","author":"Ruff","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib273","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.molcel.2017.12.022","article-title":"Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation","volume":"69","author":"Ryan","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib274","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2019053118","article-title":"Learning the molecular grammar of protein condensates from sequence determinants and embeddings","volume":"118","author":"Saar","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.arr.2025.102879_bib275","doi-asserted-by":"crossref","DOI":"10.1016\/j.febslet.2012.05.008","article-title":"The human phosphatase interactome: an intricate family portrait","author":"Sacco","year":"2012","journal-title":"FEBS Lett."},{"issue":"06","key":"10.1016\/j.arr.2025.102879_bib276","article-title":"Liquid-solid coexistence at single fibril resolution during tau condensate ageing","volume":"02","author":"Sahu","year":"2025","journal-title":"bioRxiv 2025"},{"key":"10.1016\/j.arr.2025.102879_bib277","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.725241","article-title":"Tau and membranes: interactions that promote folding and condensation","author":"Sallaberry","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib278","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168553","article-title":"Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues","author":"Samudra","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2025.102879_bib279","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108104","article-title":"Tau immunotherapies: lessons learned, current status and future considerations","volume":"175","author":"Sandusky-Beltran","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2025.102879_bib280","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.21721","article-title":"Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone","volume":"86","author":"Sarkar","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2025.102879_bib281","doi-asserted-by":"crossref","DOI":"10.1021\/cb400080f","article-title":"Untangling amyloid-\u03b2, tau, and metals in Alzheimer\u2019s disease","author":"Savelieff","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib282","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2020.05.011","article-title":"Cryo-EM structures of tau filaments","author":"Scheres","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib283","doi-asserted-by":"crossref","DOI":"10.1021\/bi981874p","article-title":"Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments","volume":"38","author":"Schneider","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib284","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102411","article-title":"Exploring advancements in early detection of Alzheimer\u2019s disease with molecular assays and animal models","volume":"100","author":"Sethi","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2025.102879_bib285","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1021\/acschemneuro.3c00578","article-title":"Identification of aggregation mechanism of acetylated PHF6* and PHF6 tau peptides based on molecular dynamics simulations and markov state modeling","volume":"14","author":"Shah","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib286","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1021\/acsmacrolett.8b00565","article-title":"Non-fickian molecular transport in protein-DNA droplets","volume":"7","author":"Shakya","year":"2018","journal-title":"ACS Macro Lett."},{"key":"10.1016\/j.arr.2025.102879_bib287","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3093(05)80472-7","article-title":"Calculation of kinetics of metastable liquid-liquid phase separation for the model with simultaneous nucleation of particles","volume":"146","author":"Shepilov","year":"1992","journal-title":"J. Non Cryst. Solids"},{"key":"10.1016\/j.arr.2025.102879_bib288","article-title":"Alzheimer\u2019s disease: etiology, neuropathology and pathogenesis","author":"Sheppard","year":"2020","journal-title":"Alzheimer\u2019S. Dis.: Drug Discov."},{"key":"10.1016\/j.arr.2025.102879_bib289","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/BJ20110739","article-title":"Critical roles of RNA helicase DDX3 and its interactions with eIF4E\/PABP1 in stress granule assembly and stress response","volume":"441","author":"Shih","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2025.102879_bib290","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/s41374-019-0202-4","article-title":"Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy","volume":"99","author":"Signaevsky","year":"2019","journal-title":"Lab. Investig."},{"key":"10.1016\/j.arr.2025.102879_bib291","doi-asserted-by":"crossref","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in alzheimer\u2019s disease and other tauopathies, and possible neuroprotective strategies","author":"\u0160imi\u0107","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102879_bib292","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1021\/acschemneuro.2c00100","article-title":"Caspase-2 inhibitor blocks tau truncation and restores excitatory neurotransmission in neurons modeling FTDP-17 tauopathy","volume":"13","author":"Singh","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib293","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.AC120.013166","article-title":"Zinc promotes liquid\u2013liquid phase separation of tau protein","volume":"295","author":"Singh","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib294","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21337","article-title":"Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3","volume":"5","author":"Smith","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.arr.2025.102879_bib295","doi-asserted-by":"crossref","DOI":"10.1001\/archneur.60.5.698","article-title":"Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia","volume":"60","author":"Sobrido","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib296","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69429-6","article-title":"EGCG impedes human tau aggregation and interacts with Tau","volume":"10","author":"Sonawane","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102879_bib297","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-021-00704-3","article-title":"Baicalein inhibits heparin-induced tau aggregation by initializing non-toxic Tau oligomer formation","volume":"19","author":"Sonawane","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102879_bib298","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13024-024-00769-x","article-title":"Comparing anti-tau antibodies under clinical trials and their epitopes on tau pathologies","volume":"19","author":"Song","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib299","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105120","article-title":"Characterization of tau binding by gosuranemab","volume":"146","author":"Sopko","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2025.102879_bib300","doi-asserted-by":"crossref","DOI":"10.1021\/bi8008856","article-title":"Structural characterization of binding of Cu(II) to Tau protein","volume":"47","author":"Soragni","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib301","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1212\/WNL.0000000000003636","article-title":"Frontotemporal dementia with the V337M MAPT mutation","volume":"88","author":"Spina","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2025.102879_bib302","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An english translation of alzheimer\u2019s 1907 paper, \u201c\u00fcber eine eigenartige erkankung der hirnrinde","volume":"8","author":"Stelzmann","year":"1995","journal-title":"Clin. Anat."},{"key":"10.1016\/j.arr.2025.102879_bib303","article-title":"In Alzheimer\u2019s disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic","volume":"148","author":"Stieber","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.arr.2025.102879_bib304","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awad411","article-title":"Amidst an amygdala renaissance in Alzheimer\u2019s disease","author":"Stouffer","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.arr.2025.102879_bib305","doi-asserted-by":"crossref","DOI":"10.1038\/s41374-019-0197-x","article-title":"MAPT mutations, tauopathy, and mechanisms of neurodegeneration","author":"Strang","year":"2019","journal-title":"Lab. Investig."},{"key":"10.1016\/j.arr.2025.102879_bib306","doi-asserted-by":"crossref","DOI":"10.1016\/j.medp.2024.100060","article-title":"Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases","volume":"1","author":"Su","year":"2024","journal-title":"Med. Plus"},{"issue":"15","key":"10.1016\/j.arr.2025.102879_bib307","first-page":"1","article-title":"Precise prediction of phase-separation key residues by machine learning","volume":"151","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102879_bib308","doi-asserted-by":"crossref","DOI":"10.1021\/acs.biochem.6b01088","article-title":"Phase to phase with TDP-43","author":"Sun","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2025.102879_bib309","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000614","article-title":"Molecular determinants and genetic modifiers of aggregation and toxicity for the als disease protein fus\/tls","volume":"9","author":"Sun","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2025.102879_bib310","doi-asserted-by":"crossref","DOI":"10.1248\/cpb.c24-00069","article-title":"Anti-amyloid-\u03b2 antibodies and anti-tau therapies for Alzheimer\u2019s disease: recent advances and perspectives","volume":"72","author":"Suzuki","year":"2024","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.arr.2025.102879_bib311","doi-asserted-by":"crossref","DOI":"10.1002\/alz.076888","article-title":"APNmAb005, an anti-tau antibody targeting synaptic tau oligomers, in Phase 1 for treatment of Alzheimer\u2019s Disease and primary tauopathies","volume":"19","author":"Tai","year":"2023","journal-title":"Alzheimer\u2019S. Dement"},{"key":"10.1016\/j.arr.2025.102879_bib312","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/B978-0-12-802973-2.00013-6","article-title":"The epidemiology of amyotrophic lateral sclerosis","volume":"138","author":"Talbott","year":"2016","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib313","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2018.12.005","article-title":"It\u2019s all about tau","author":"Tapia-Rojas","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2025.102879_bib314","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1126\/science.1067122","article-title":"Toxic proteins in neurodegenerative disease","volume":"296","author":"Taylor","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102879_bib315","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102879_bib316","doi-asserted-by":"crossref","unstructured":"Mondrag\u00f3n-Rodr\u00edguez, S., Perry, G., Zhu, X., Moreira, P.I., Acevedo-Aquino, M.C., Williams, S., 2013. Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer\u2019s Disease. Oxid. Med. Cell. Longev. 2013, 1\u20136. https:\/\/doi.org\/10.1155\/2013\/940603.","DOI":"10.1155\/2013\/940603"},{"key":"10.1016\/j.arr.2025.102879_bib317","unstructured":"The history of Alzheimer\u2019s disease [WWW Document], n.d."},{"key":"10.1016\/j.arr.2025.102879_bib318","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25143130","article-title":"RNA granules: a view from the RNA perspective","author":"Tian","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102879_bib319","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201600224","article-title":"Acetylated tau in Alzheimer\u2019s disease: an instigator of synaptic dysfunction underlying memory loss","volume":"39","author":"Tracy","year":"2017","journal-title":"BioEssays"},{"key":"10.1016\/j.arr.2025.102879_bib320","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13311-021-01146-y","article-title":"Neuropathology of Alzheimer\u2019s disease","volume":"19","author":"Trejo-Lopez","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2025.102879_bib321","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/jamaneurol.2019.3812","article-title":"Reactions to multiple ascending doses of the microtubule stabilizer TPI-287 in patients with Alzheimer disease, progressive supranuclear palsy, and corticobasal syndrome: a randomized clinical trial","volume":"77","author":"Tsai","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib322","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/acn3.171","article-title":"Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice","volume":"2","author":"Umeda","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib323","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sbi.2016.10.015","article-title":"Intrinsically disordered proteins in overcrowded milieu: membrane-less organelles, phase separation, and intrinsic disorder","volume":"44","author":"Uversky","year":"2017","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib324","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2016.05.012","article-title":"Protein intrinsic disorder-based liquid\u2013liquid phase transitions in biological systems: complex coacervates and membrane-less organelles","author":"Uversky","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.arr.2025.102879_bib325","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0531-5565(00)00114-5","article-title":"The molecular genetics of the tauopathies","volume":"35","author":"Van Slegtenhorst","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102879_bib326","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1750-3639.2007.00052.x","article-title":"Hereditary frontotemporal dementia caused by tau gene mutations","volume":"17","author":"Van Swieten","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.arr.2025.102879_bib327","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s13311-020-00888-5","article-title":"Four-repeat tauopathies: current management and future treatments","volume":"17","author":"VandeVrede","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2025.102879_bib328","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.788300","article-title":"Protein science meets artificial intelligence: a systematic review and a biochemical meta-analysis of an inter-field","volume":"10","author":"Villalobos-Alva","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2025.102879_bib329","doi-asserted-by":"crossref","first-page":"S527","DOI":"10.3233\/JAD-2010-100501","article-title":"Why women have more Alzheimer\u2019s disease than men: gender and mitochondrial toxicity of amyloid-\u03b2 peptide","volume":"20","author":"Vi\u00f1a","year":"2010","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.arr.2025.102879_bib330","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-0716-1712-0_4","article-title":"Tau pathology in neurodegenerative diseases","volume":"173","author":"Vogels","year":"2022","journal-title":"Neuromethods"},{"key":"10.1016\/j.arr.2025.102879_bib331","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.11.12.4093","article-title":"Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells","volume":"11","author":"Vogelsberg-Ragaglia","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib332","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M105196200","article-title":"Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local \u03b2-structure","volume":"276","author":"Von Bergen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib333","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adm7435","article-title":"Specific protein-RNA interactions are mostly preserved in biomolecular condensates","volume":"10","author":"de Vries","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2025.102879_bib334","doi-asserted-by":"crossref","DOI":"10.1007\/s12033-009-9193-5","article-title":"On and around microtubules: an overview","author":"Wade","year":"2009","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.arr.2025.102879_bib335","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2025.102879_bib336","article-title":"Liquid\u2013liquid phase separation in human health and diseases","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib337","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.06.019","article-title":"Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies via paraspeckle LncRNA NEAT1-mediated liquid-liquid phase separation","volume":"79","author":"Wang","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib338","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2018.06.006","article-title":"A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins","volume":"174","author":"Wang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib339","first-page":"688","volume":"174","author":"Wang","year":"2019","journal-title":"HHS Public Access"},{"key":"10.1016\/j.arr.2025.102879_bib340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2020.02.013","article-title":"Phase separation and cytotoxicity of tau are modulated by protein disulfide isomerase and s-nitrosylation of this molecular chaperone","volume":"432","author":"Wang","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib341","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-024-01518-9","article-title":"Phase separation-mediated biomolecular condensates and their relationship to tumor","volume":"22","author":"Wang","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.arr.2025.102879_bib342","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12647","article-title":"Significance of cytosolic cathepsin D in Alzheimer\u2019s disease pathology: protective cellular effects of PLGA nanoparticles against \u03b2-amyloid-toxicity","author":"Wang","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.arr.2025.102879_bib343","article-title":"Essence determines phenomenon: assaying the material properties of biological condensates","author":"Wang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib344","doi-asserted-by":"crossref","DOI":"10.1042\/BST20120134","article-title":"Tau oligomers and tau toxicity in neurodegenerative disease","author":"Ward","year":"2012","journal-title":": Biochem. Soc. Trans."},{"key":"10.1016\/j.arr.2025.102879_bib345","doi-asserted-by":"crossref","DOI":"10.1016\/S0079-6700(99)00029-5","article-title":"Viscoelasticity and dynamics of entangled polymers","author":"Watanabe","year":"1999","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib346","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2015.01.012","article-title":"Inverse size scaling of the nucleolus by a concentration-dependent phase transition","volume":"25","author":"Weber","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2025.102879_bib347","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798049","article-title":"Tau protein liquid\u2013liquid phase separation can initiate tau aggregation","volume":"37","author":"Wegmann","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2025.102879_bib348","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neuropharm.2007.12.006","article-title":"Role of calpain and caspase in \u03b2-amyloid-induced cell death in rat primary septal cultured neurons","volume":"54","author":"Wei","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2025.102879_bib349","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00019442-200510000-00003","article-title":"Psychiatric complications in Parkinson disease","volume":"13","author":"Weintraub","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.arr.2025.102879_bib350","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1021\/jacs.1c03078","article-title":"Conformational expansion of tau in condensates promotes irreversible aggregation","volume":"143","author":"Wen","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.arr.2025.102879_bib351","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/ETLS20190176","article-title":"Therapeutics\u2014how to treat phase separation-associated diseases","volume":"4","author":"Wheeler","year":"2020","journal-title":"Emerg. Top. Life Sci."},{"key":"10.1016\/j.arr.2025.102879_bib352","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.83.11.4040","article-title":"Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)","volume":"83","author":"Wood","year":"1986","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib353","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2017.11.005","article-title":"Organization and function of non-dynamic biomolecular condensates","author":"Woodruff","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2025.102879_bib354","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-1-30","article-title":"Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)","author":"Wszolek","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.arr.2025.102879_bib355","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.ijbiomac.2022.08.148","article-title":"Native PLGA nanoparticles regulate APP metabolism and protect neurons against \u03b2-amyloid toxicity: potential significance in Alzheimer\u2019s disease pathology","volume":"219","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102879_bib356","doi-asserted-by":"crossref","first-page":"18488","DOI":"10.1074\/jbc.RA119.010178","article-title":"Impaired tau\u2013microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations","volume":"294","author":"Xia","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib357","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-021-00460-5","article-title":"Don\u2019t Phos Over Tau\u201d: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer\u2019s disease and other tauopathies","volume":"16","author":"Xia","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib358","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13024-025-00854-9","article-title":"Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition","volume":"20","author":"Xiang","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib359","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224952","article-title":"Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization","volume":"15","author":"Yadikar","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2025.102879_bib360","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.03.046","article-title":"G3BP1 is a tunable switch that triggers phase separation to assemble stress granules","volume":"181","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib361","first-page":"17","article-title":"Prediction of cognitive conversion within the Alzheimer\u2019s disease continuum using deep learning","author":"Yang","year":"2025","journal-title":"Alzheimer\u2019S. Res. Ther."},{"key":"10.1016\/j.arr.2025.102879_bib362","first-page":"47","article-title":"A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)","author":"Yasuda","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib363","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s12031-022-02002-0","article-title":"The role of post-translational modifications on the structure and function of tau protein","volume":"72","author":"Ye","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.arr.2025.102879_bib364","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cjche.2022.09.013","article-title":"Proanthocyanidins prevent tau protein aggregation and disintegrate tau filaments","volume":"57","author":"Yin","year":"2023","journal-title":"Chin. J. Chem. Eng."},{"key":"10.1016\/j.arr.2025.102879_bib365","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2018.03.003","article-title":"Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites","volume":"173","author":"Yoshizawa","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102879_bib366","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/1873-3468.13116","article-title":"RNA-protein interactions in an unstructured context","volume":"592","author":"Zagrovic","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2025.102879_bib367","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.devcel.2020.09.014","article-title":"Phase separation and neurodegenerative diseases: a disturbance in the force","volume":"55","author":"Zbinden","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.arr.2025.102879_bib368","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-020-03681-x","article-title":"The structure and phase of tau: from monomer to amyloid filament","author":"Zeng","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102879_bib369","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.2002183","article-title":"RNA stores tau reversibly in complex coacervates","volume":"15","author":"Zhang","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2025.102879_bib370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-023-00388-4","article-title":"Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies","volume":"13","author":"Zhang","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib371","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-022-00533-z","article-title":"Tauopathies: new perspectives and challenges","author":"Zhang","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib372","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6606-4-3","article-title":"APP processing in Alzheimer\u2019s disease","volume":"4","author":"Zhang","year":"2011","journal-title":"Mol. Brain"},{"key":"10.1016\/j.arr.2025.102879_bib373","article-title":"Anti-IgLON5 disease: a novel topic beyond neuroimmunology","author":"Zhang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2025.102879_bib374","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-019-0179-3","article-title":"\u03b4-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities","author":"Zhang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2025.102879_bib375","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2017.01.024","article-title":"Glycan determinants of heparin-tau interaction","volume":"112","author":"Zhao","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.arr.2025.102879_bib376","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M109.002832","article-title":"Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding","volume":"284","author":"Zhou","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2025.102879_bib377","first-page":"51","article-title":"Sporadic pick\u2019s disease: a tauopathy characterized by a spectrum of pathological \u03c4 isoforms in gray and white matter","author":"Zhukareva","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2025.102879_bib378","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/alzrt251","article-title":"Lewy body dementia: the impact on patients and caregivers","volume":"6","author":"Zweig","year":"2014","journal-title":"Alzheimers Res. Ther."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:42:30Z","timestamp":1765384950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725002259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":378,"alternative-id":["S1568163725002259"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102879","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomolecular phase separation of microtubule-associated protein tau and its role in the genesis of brain disorders","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102879"}}