{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:22:21Z","timestamp":1791588141925,"version":"4.3.4"},"reference-count":308,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.arr.2025.102930","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:24:42Z","timestamp":1762331082000},"page":"102930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Exploring the causal relationship between telomere regulation, aging and neurological disorders"],"prefix":"10.1016","volume":"113","author":[{"given":"Gaurav","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.arr.2025.102930_bib1","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.3390\/nu15153456","article-title":"Underlying mechanisms of brain aging and neurodegenerative diseases as potential targets for preventive or therapeutic strategies using phytochemicals","volume":"15","author":"Abdolmaleky","year":"2023","journal-title":"Nutrients"},{"issue":"25","key":"10.1016\/j.arr.2025.102930_bib2","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib3","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.3390\/ijms21072477","article-title":"Extrachromosomal circular DNA: current knowledge and implications for CNS aging and neurodegeneration","volume":"21","author":"Ain","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.arr.2025.102930_bib4","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.2174\/092986712802002590","article-title":"DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets","volume":"19","author":"Alagoz","year":"2012","journal-title":"Curr. Med Chem."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10238-025-01564-8","article-title":"Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?","volume":"25","author":"Alavimanesh","year":"2025","journal-title":"Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib6","first-page":"3822","article-title":"A significance correlation between malignant tumors and telomerase","volume":"25","author":"Al-Khafaf","year":"2021","journal-title":"Ann. Rom. Soc. Cell Biol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020359","article-title":"Structural Features of Nucleoprotein CST\/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations","volume":"9","author":"Amir","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.arr.2025.102930_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.799380","article-title":"Immunosenescence and autoimmunity: exploiting the T-cell receptor repertoire to investigate the impact of aging on multiple sclerosis","volume":"12","author":"Amoriello","year":"2021","journal-title":"Front. Immunol."},{"issue":"7-9","key":"10.1016\/j.arr.2025.102930_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/ars.2023.0285","article-title":"Expanding the frontiers of guardian antioxidant selenoproteins in cardiovascular pathophysiology","volume":"40","author":"Angelone","year":"2024","journal-title":"Antioxid. Redox Signal."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib10","first-page":"2004","article-title":"Telomerase as a therapeutic target in glioblastoma","volume":"23","author":"Aquilanti","year":"2021","journal-title":"NeuroOncol."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0268689","article-title":"Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study","volume":"17","author":"Armstrong","year":"2022","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib12","doi-asserted-by":"crossref","first-page":"17578","DOI":"10.1038\/s41598-022-22400-z","article-title":"Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson\u2019s disease and Lewy body dementia","volume":"12","author":"Asghar","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib13","doi-asserted-by":"crossref","first-page":"17578","DOI":"10.1038\/s41598-022-22400-z","article-title":"Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson's disease and Lewy body dementia","volume":"12","author":"Asghar","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102930_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.683459","article-title":"The ageing brain: molecular and cellular basis of neurodegeneration","volume":"9","author":"Azam","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1872214808666140608145810","volume":"8","author":"Babizhayev","year":"2014","journal-title":"Endocr. Metab. Immune Drug Discov."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib16","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1097\/MJT.0b013e3181cf8ebb","article-title":"Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior","volume":"18","author":"Babizhayev","year":"2011","journal-title":"Am. J. Ther."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s42764-023-00110-8","article-title":"Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain","volume":"4","author":"Babu","year":"2023","journal-title":"Genome Instab. Dis."},{"key":"10.1016\/j.arr.2025.102930_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102236","article-title":"Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation","volume":"95","author":"Bashir","year":"2024","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102930_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102689","article-title":"Bridging gap in the treatment of Alzheimer's disease via postbiotics: Current practices and future prospects","volume":"105","author":"Bashir","year":"2025","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102930_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awaf018","article-title":"Mendelian randomization identifies proteins involved in neurodegenerative diseases","author":"Belbasis","year":"2025","journal-title":"Brain"},{"issue":"2 Pt 2","key":"10.1016\/j.arr.2025.102930_bib21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/01.HYP.37.2.381","article-title":"Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity","volume":"37","author":"Benetos","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.arr.2025.102930_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-017-0895-4","article-title":"Biological embedding of childhood adversity: from physiological mechanisms to clinical implications","volume":"15","author":"Berens","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.arr.2025.102930_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2022.103342","article-title":"New twists to the ALTernative endings at telomeres","volume":"115","author":"Bhargava","year":"2022","journal-title":"DNA Repair"},{"issue":"6265","key":"10.1016\/j.arr.2025.102930_bib24","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.aab3389","article-title":"Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection","volume":"350","author":"Blackburn","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102930_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2015.04.003","article-title":"From cellular senescence to Alzheimer\u2019s disease: The role of telomere shortening","volume":"22","author":"Boccardi","year":"2015","journal-title":"Ageing Res. Rev."},{"issue":"15","key":"10.1016\/j.arr.2025.102930_bib26","doi-asserted-by":"crossref","first-page":"8542","DOI":"10.3390\/ijms25158542","article-title":"Aging, cancer, and inflammation: the telomerase connection","volume":"25","author":"Boccardi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41582-022-00733-7","article-title":"Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials","volume":"18","author":"Brenowitz","year":"2022","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib28","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.14336\/AD.2021.0106","article-title":"Systematic review of studies on telomere length in patients with multiple sclerosis","volume":"12","author":"B\u00fchring","year":"2021","journal-title":"Aging Dis."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020159","article-title":"No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study","volume":"8","author":"Cao","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12967-020-02551-1","article-title":"Association between telomere length in peripheral blood leukocytes and risk of ischemic stroke in a Han Chinese population: a linear and non-linear Mendelian randomization analysis","volume":"18","author":"Cao","year":"2020","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.arr.2025.102930_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2023.578137","article-title":"Leukocyte telomere length in women with multiple sclerosis: Comparison with healthy women during pregnancy and puerperium","volume":"381","author":"Caria","year":"2023","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib32","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.1038\/s41598-023-34922-1","article-title":"DNA methylation variations and epigenetic aging in telomere biology disorders","volume":"13","author":"Carlund","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13238-016-0322-1","article-title":"TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence","volume":"8","author":"Cassar","year":"2017","journal-title":"Protein Cell"},{"issue":"22","key":"10.1016\/j.arr.2025.102930_bib34","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.3390\/cancers13225791","article-title":"Oxidative stress and autophagy as key targets in melanoma cell fate","volume":"13","author":"Catalani","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib35","first-page":"2105607","article-title":"Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view","volume":"2019","author":"Cenini","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1441","key":"10.1016\/j.arr.2025.102930_bib36","first-page":"109","article-title":"Telomeres and telomerase","volume":"359","author":"Chan","year":"2004","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"24","key":"10.1016\/j.arr.2025.102930_bib37","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1073\/pnas.92.24.11190","article-title":"Telomere length and replicative aging in human vascular tissues","volume":"92","author":"Chang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12916-021-02217-9","article-title":"Variability in newborn telomere length is explained by inheritance and intrauterine environment","volume":"20","author":"Chen","year":"2022","journal-title":"BMC Med."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.36","article-title":"Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction","volume":"3","author":"Cheng","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/neuonc\/noy123","article-title":"Distinct genomic profile and specific targeted drug responses in adult cerebellar glioblastoma","volume":"21","author":"Cho","year":"2019","journal-title":"Neuro Oncol."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/genes14040790","article-title":"ATRX\/DAXX: guarding the genome against the hazards of ALT","volume":"14","author":"Clatterbuck Soper","year":"2023","journal-title":"Genes"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib42","article-title":"The Shortening of Leukocyte Telomere Length Contributes to Alzheimer's Disease: Further Evidence from Late-Onset Familial and Sporadic Cases","volume":"12","author":"Crocco","year":"2023","journal-title":"Biol. (Basel)"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib43","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s11033-024-10077-8","article-title":"Telomere length as a biomarker for cerebrovascular diseases: current evidence","volume":"51","author":"da Cunha Agostini","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib44","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3390\/antiox12122086","article-title":"Diet and aging: the role of polyphenol-rich diets in slow down the shortening of telomeres: a review","volume":"12","author":"D\u2019Angelo","year":"2023","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib45","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.4049\/jimmunol.179.6.4249","article-title":"Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients","volume":"179","author":"Damjanovic","year":"2007","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.arr.2025.102930_bib46","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: the protein complex that shapes and safeguards human telomeres","volume":"19","author":"De Lange","year":"2005","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","article-title":"Shelterin-mediated telomere protection","volume":"52","author":"De Lange","year":"2018","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.arr.2025.102930_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.758402","article-title":"Roles for the 8-oxoguanine DNA repair system in protecting telomeres from oxidative stress","volume":"9","author":"De Rosa","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib49","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/ijms19020606","article-title":"Telomere length maintenance in cancer: at the crossroad between telomerase and alternative lengthening of telomeres (ALT)","volume":"19","author":"De Vitis","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102930_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150021","article-title":"Extracellular vesicles deviced from hypoxia-3D-GMSCs rescue the mitochondrial dysfunction of aging-GMSCs","volume":"717","author":"Deng","year":"2024","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.arr.2025.102930_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108977","article-title":"The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases","volume":"710","author":"D'Errico","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.arr.2025.102930_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105559","article-title":"Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatment","volume":"112","author":"Desu","year":"2025","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/ijms19020333","article-title":"Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites","volume":"19","author":"Dey","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/cells13010044","article-title":"The Biological and Clinical Role of the Telomerase Reverse Transcriptase Gene in Glioblastoma: A Potential Therapeutic Target?","volume":"13","author":"Di Nunno","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib56","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1089\/rej.2018.2115","article-title":"Role of senescence and neuroprotective effects of telomerase in neurodegenerative diseases","volume":"23","author":"Ding","year":"2020","journal-title":"Rejuvenation Res."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib57","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/nucl.2.2.15135","article-title":"Shelterin complex and associated factors at human telomeres","volume":"2","author":"Diotti","year":"2011","journal-title":"Nucleus"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib58","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3390\/cancers13061213","article-title":"Telomerase regulation: a role for epigenetics","volume":"13","author":"Dogan","year":"2021","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib59","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tins.2014.02.010","article-title":"Telomere shortening in neurological disorders: an abundance of unanswered questions","volume":"37","author":"Eitan","year":"2014","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib60","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrc1142","article-title":"Telomere dysfunction and the initiation of genome instability","volume":"3","author":"Feldser","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib61","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2025.102930_bib62","series-title":"AARP The Immortality Edge: Realize the Secrets of Your Telomeres for a Longer, Healthier Life","author":"Fossel","year":"2012"},{"key":"10.1016\/j.arr.2025.102930_bib63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mrrev.2015.08.001","article-title":"Super DNAging\u2014new insights into DNA integrity, genome stability and telomeres in the oldest old","volume":"766","author":"Franzke","year":"2015","journal-title":"Mutat. Res. \/Rev. Mutat. Res."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib64","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrcardio.2013.30","article-title":"The roles of senescence and telomere shortening in cardiovascular disease","volume":"10","author":"Fyhrquist","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib66","doi-asserted-by":"crossref","first-page":"867","DOI":"10.18632\/aging.100235","article-title":"Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes","volume":"2","author":"Gadalla","year":"2010","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib67","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1161\/STROKEAHA.121.037419","article-title":"Biological Age Acceleration Is Lower in Women With Ischemic Stroke Compared to Men","volume":"53","author":"Gallego-Fabrega","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.arr.2025.102930_bib68","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fpsyt.2020.00100","article-title":"Leukocyte Telomere Length Is Related to Brain Parenchymal Fraction and Attention\/Speed in the Elderly: Results of the Austrian Stroke Prevention Study","volume":"11","author":"Gampawar","year":"2020","journal-title":"Front Psychiatry"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib69","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/biof.2009","article-title":"Exploring the therapeutic potential of naturally occurring piceatannol in non-communicable diseases","volume":"50","author":"Gandhi","year":"2024","journal-title":"Biofactors"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib70","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12031-018-1160-9","article-title":"Relative Telomere Length and Stroke Risk in a Chinese Han Population","volume":"66","author":"Gao","year":"2018","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib71","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12031-018-1160-9","article-title":"Relative Telomere Length and Stroke Risk in a Chinese Han Population","volume":"66","author":"Gao","year":"2018","journal-title":"J. Mol. Neurosci."},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib72","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41568-022-00490-1","article-title":"Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies","volume":"22","author":"Gao","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.arr.2025.102930_bib73","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3389\/fpsyt.2019.00843","article-title":"Exploring the Causal Pathway From Telomere Length to Alzheimer's Disease: An Update Mendelian Randomization Study","volume":"10","author":"Gao","year":"2019","journal-title":"Front Psychiatry"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib74","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/biology10040253","article-title":"Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging","volume":"10","author":"Gavia-Garc\u00eda","year":"2021","journal-title":"Biology"},{"issue":"22","key":"10.1016\/j.arr.2025.102930_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900629","article-title":"Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53\/p21 and p16\/Rb Pathways, and ABC Transporters","volume":"63","author":"Gim\u00e9nez-Bastida","year":"2019","journal-title":"Mol. Nutr. Food Res"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib76","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/1097-0142(20001115)89:10<2068::AID-CNCR6>3.0.CO;2-Z","article-title":"Ovarian carcinoma diagnosis","volume":"89","author":"Goff","year":"2000","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib77","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1515\/cclm-2019-0235","article-title":"Telomere length determinants in childhood","volume":"58","author":"Gorenjak","year":"2020","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"issue":"18","key":"10.1016\/j.arr.2025.102930_bib78","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/10.18.1953","article-title":"Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway","volume":"10","author":"Grobelny","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101335","article-title":"Telomeres and Age-Related Diseases","volume":"9","author":"Gruber","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib80","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40520-013-0006-0","article-title":"Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer's disease","volume":"25","author":"Guan","year":"2013","journal-title":"Aging Clin. Exp. Res"},{"issue":"1-2","key":"10.1016\/j.arr.2025.102930_bib81","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11010-014-2274-1","article-title":"Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening","volume":"400","author":"Guan","year":"2015","journal-title":"Mol. Cell Biochem"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib82","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40520-013-0006-0","article-title":"Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer\u2019s disease","volume":"25","author":"Guan","year":"2013","journal-title":"Aging Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11010-014-2274-1","article-title":"Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening","volume":"400","author":"Guan","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib84","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.3390\/ijms23094508","article-title":"Pathophysiological features of nigral dopaminergic neurons in animal models of Parkinson\u2019s disease","volume":"23","author":"Guatteo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.arr.2025.102930_bib85","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1038\/sj.emboj.7601893","article-title":"Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis","volume":"26","author":"Guo","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2025.102930_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-13-232","article-title":"Targeting DNA-PKcs and telomerase in brain tumour cells","volume":"13","author":"Gurung","year":"2014","journal-title":"Mol. Cancer"},{"issue":"36","key":"10.1016\/j.arr.2025.102930_bib87","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1038\/s41388-020-01405-w","article-title":"Targeting telomerase for cancer therapy","volume":"39","author":"Guterres","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2025.102930_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577187","article-title":"Association between shorter leukocyte telomeres and multiple sclerosis","volume":"341","author":"Habib","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.arr.2025.102930_bib89","first-page":"349","article-title":"Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis","author":"Haycock","year":"2014","journal-title":"Bmj"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib90","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3390\/biom11101510","article-title":"Genetic, environmental and lifestyle determinants of accelerated telomere attrition as contributors to risk and severity of multiple sclerosis","volume":"11","author":"Hecker","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102930_bib91","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1007\/s12035-021-02315-y","article-title":"Leukocyte telomere length in patients with multiple sclerosis and its association with clinical phenotypes","volume":"58","author":"Hecker","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib92","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1007\/s12035-021-02315-y","article-title":"Leukocyte Telomere Length in Patients with Multiple Sclerosis and Its Association with Clinical Phenotypes","volume":"58","author":"Hecker","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102930_bib93","unstructured":"Heininger, K., n.d. Aging is selected for, adaptive, and programmed. 31. Is there a fountain of youth?"},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib94","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3390\/biom13071085","article-title":"Counteracting Immunosenescence\u2014Which Therapeutic Strategies Are Promising?","volume":"13","author":"Hieber","year":"2023","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib95","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.20894","article-title":"Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia","volume":"60","author":"Honig","year":"2006","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib96","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.20894","article-title":"Shorter telomeres are associated with mortality in those with APOE \u03f54 and dementia","volume":"60","author":"Honig","year":"2006","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib97","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/carcin\/bgg085","article-title":"Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms","volume":"24","author":"Horikawa","year":"2003","journal-title":"Carcinogenesis"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib98","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.18632\/aging.100859","article-title":"Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients","volume":"7","author":"Horvath","year":"2015","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib99","article-title":"Highly Sensitive Room-Temperature Sensor Based on Nanostructured K\u2082W\u2087O(22) for Application in the Non-Invasive Diagnosis of Diabetes","volume":"18","author":"Hossain","year":"2018","journal-title":"Sens. (Basel)"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ebiom.2015.04.008","article-title":"Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort","volume":"2","author":"Hou","year":"2015","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib101","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2025.102930_bib102","author":"Hub\u00e1\u010dkov\u00e1","year":"2014","journal-title":"DNA Damage Signal. Pathw. Cell. senescence"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib103","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1080\/10286020.2024.2371040","article-title":"Mechanisms and therapeutic potential of chinonin in nervous system diseases","volume":"26","author":"Hui","year":"2024","journal-title":"J. Asian Nat. Prod. Res"},{"key":"10.1016\/j.arr.2025.102930_bib104","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000059794","article-title":"Predisposing genes, high-risk environments and coronary artery disease: LPL and fibrinogen as examples","volume":"89","author":"Humphries","year":"2001","journal-title":"World Rev. Nutr. Diet."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib105","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3390\/nu12061562","article-title":"Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis","volume":"12","author":"Iddir","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12041028","article-title":"Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors","volume":"12","author":"Idilli","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2025.102930_bib107","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-024-01334-6","article-title":"Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization","author":"Imahori","year":"2024","journal-title":"Geroscience"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib108","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3233\/JAD-180164","article-title":"Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial","volume":"66","author":"Innes","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib109","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/antiox6010015","article-title":"Treating cancer by targeting telomeres and telomerase","volume":"6","author":"Ivancich","year":"2017","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2025.102930_bib110","article-title":"Worse Physical Disability Is Associated With the Expression of PD-1 on Inflammatory T-Cells in Multiple Sclerosis Patients With Older Appearing Brains","volume":"12","author":"Jacobs","year":"2021","journal-title":"Front Neurol."},{"issue":"32","key":"10.1016\/j.arr.2025.102930_bib111","doi-asserted-by":"crossref","first-page":"11299","DOI":"10.1073\/pnas.0801457105","article-title":"Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease","volume":"105","author":"Jiang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/npr2.70009","article-title":"Epigenetic Clock Analysis for National Institutes of Health Stroke Scale in Patients With Ischemic Stroke","volume":"45","author":"Jiang","year":"2025","journal-title":"Neuropsychopharmacol. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib113","doi-asserted-by":"crossref","DOI":"10.1002\/npr2.70009","article-title":"Epigenetic Clock Analysis for National Institutes of Health Stroke Scale in Patients With Ischemic Stroke","volume":"45","author":"Jiang","year":"2025","journal-title":"Neuropsychopharmacol. Rep."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068254","article-title":"Decreased leukocyte telomere length (LTL) is associated with stroke but unlikely to be causative","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib115","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI84547","article-title":"The shelterin complex and hematopoiesis","volume":"126","author":"Jones","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2025.102930_bib116","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","article-title":"Biological age predictors","volume":"21","author":"Jylh\u00e4v\u00e4","year":"2017","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib117","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1753-4887.2012.00504.x","article-title":"From clock genes to telomeres in the regulation of the healthspan","volume":"70","author":"Kagawa","year":"2012","journal-title":"Nutr. Rev."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib118","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00432-024-05867-3","article-title":"TRF1 and TRF2: pioneering targets in telomere-based cancer therapy","volume":"150","author":"Kallingal","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.arr.2025.102930_bib119","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer\u2019s disease: understanding the therapeutics strategies","volume":"53","author":"Kamat","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102930_bib120","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00018-004-4174-0","article-title":"DNA damage repair and transcription: Double-strand breaks: signaling pathways and repair mechanisms","volume":"61","author":"Karagiannis","year":"2004","journal-title":"Cell. Mol. Life Sci. CMLS"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib121","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/0118715273321002240919102841","article-title":"Exploring Therapeutic Strategies: The Relationship between Metabolic Disorders and FOXO Signalling in Alzheimer's Disease","volume":"24","author":"Kaur","year":"2025","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib122","article-title":"Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease","volume":"14","author":"Kim","year":"2022","journal-title":"Alzheimers Dement (Amst. )"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib123","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13073-022-01095-x","article-title":"The telomere maintenance mechanism spectrum and its dynamics in gliomas","volume":"14","author":"Kim","year":"2022","journal-title":"Genome Med."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2000016","article-title":"Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer","volume":"14","author":"Kim","year":"2016","journal-title":"PLoS Biol."},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/genes7090060","article-title":"The telomere\/telomerase system in chronic inflammatory diseases. Cause or effect?","volume":"7","author":"Kordinas","year":"2016","journal-title":"Genes"},{"key":"10.1016\/j.arr.2025.102930_bib126","series-title":"Synoptic Mapping of Dna Damage in the Replicative Senescence of Human Fibroblasts","author":"K\u00f6se","year":"2023"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102937","article-title":"Ageing, Cellular Senescence and Neurodegenerative Disease","volume":"19","author":"Kritsilis","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib128","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1007\/s12035-023-03337-4","article-title":"Exploring the causal relationship between telomere biology and Alzheimer\u2019s disease","volume":"60","author":"Kuan","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102930_bib129","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.926468","article-title":"Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients","volume":"14","author":"Kular","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib130","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1038\/s41598-023-32974-x","article-title":"The associations of socioeconomic status with incident dementia and Alzheimer\u2019s disease are modified by leucocyte telomere length: a population-based cohort study","volume":"13","author":"Lai","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib131","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1038\/s41598-023-32974-x","article-title":"The associations of socioeconomic status with incident dementia and Alzheimer's disease are modified by leucocyte telomere length: a population-based cohort study","volume":"13","author":"Lai","year":"2023","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib132","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nrm.2016.43","article-title":"Stop pulling my strings\u2014what telomeres taught us about the DNA damage response","volume":"17","author":"Lazzerini-Denchi","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib133","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.18632\/aging.202206","article-title":"Relationship between telomere shortening and age in Korean individuals with mild cognitive impairment and Alzheimer's disease compared to that in healthy controls","volume":"13","author":"Lee","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib134","article-title":"Analysis of the Association between Telomere Length and Neurological Disability in Stroke Types","volume":"60","author":"Lee","year":"2024","journal-title":"Med. (Kaunas. )"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13195-024-01635-0","article-title":"Association of critically short telomeres with brain and blood markers of ageing and Alzheimer's disease in older adults","volume":"16","author":"Lehodey","year":"2024","journal-title":"Alzheimers Res Ther."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib136","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/antiox10010137","article-title":"Assessment of the telomere length and its effect on the symptomatology of Parkinson\u2019s disease","volume":"10","author":"Levstek","year":"2021","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib137","article-title":"Assessment of the Telomere Length and Its Effect on the Symptomatology of Parkinson's Disease","volume":"10","author":"Levstek","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib138","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.18632\/oncotarget.7864","article-title":"Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib139","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1007\/s12035-016-0086-x","article-title":"Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population","volume":"54","author":"Liang","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib140","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1007\/s12035-016-0086-x","article-title":"Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population","volume":"54","author":"Liang","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib141","first-page":"2595","article-title":"Telomeres: dysfunction, maintenance, aging and cancer","volume":"15","author":"Liao","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2025.102930_bib142","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.922922","article-title":"A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study","volume":"13","author":"Liao","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib143","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1186\/s12889-024-18588-6","article-title":"Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants","volume":"24","author":"Lin","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.arr.2025.102930_bib144","article-title":"Duke University","author":"Liu","year":"2022","journal-title":"Telomere Replica Stress Cancer Stem Cell"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13072-025-00567-9","article-title":"Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study","volume":"18","author":"Liu","year":"2025","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib146","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13072-025-00567-9","article-title":"Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study","volume":"18","author":"Liu","year":"2025","journal-title":"Epigenetics Chromatin"},{"issue":"34","key":"10.1016\/j.arr.2025.102930_bib147","doi-asserted-by":"crossref","first-page":"31998","DOI":"10.1074\/jbc.M303553200","article-title":"Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib148","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13808","article-title":"Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants","volume":"22","author":"Liu","year":"2023","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib149","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3390\/ijms23041989","article-title":"Aging, cellular senescence, and Alzheimer\u2019s disease","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib150","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.21037\/tcr-23-2294","article-title":"Development and validation of a glioma prognostic model based on telomere-related genes and immune infiltration analysis","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Cancer Res"},{"issue":"6943","key":"10.1016\/j.arr.2025.102930_bib151","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nature01688","article-title":"POT1 as a terminal transducer of TRF1 telomere length control","volume":"423","author":"Loayza","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24020916","article-title":"Leukocyte Telomere Length Predicts Severe Disability in Relapsing-Remitting Multiple Sclerosis and Correlates with Mitochondrial DNA Copy Number","volume":"24","author":"L\u00f3pez-Armas","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib153","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/neuonc\/nos329","article-title":"Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age","volume":"15","author":"L\u00f6tsch","year":"2013","journal-title":"Neuro Oncol."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib154","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jalz.2009.05.666","article-title":"Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease","volume":"5","author":"Lukens","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2025.102930_bib155","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3389\/fimmu.2017.01027","article-title":"Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans","volume":"8","author":"Lustig","year":"2017","journal-title":"Front Immunol."},{"issue":"1-2","key":"10.1016\/j.arr.2025.102930_bib156","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000501958","article-title":"Association of leukocyte telomere length with mild cognitive impairment and Alzheimer\u2019s disease: role of folate and homocysteine","volume":"48","author":"Ma","year":"2019","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib157","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2016.171","article-title":"Telomeres in cancer: tumour suppression and genome instability","volume":"18","author":"Maciejowski","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib158","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1136\/ard.2007.086652","article-title":"Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion","volume":"67","author":"MacIntyre","year":"2008","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib159","first-page":"1571","article-title":"Relation between telomerase activity, hTERT and telomere length for intracranial tumours","volume":"18","author":"Maes","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.arr.2025.102930_bib160","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.trci.2019.11.003","article-title":"Telomere length associations with cognition depend on Alzheimer's disease biomarkers","volume":"5","author":"Mahoney","year":"2019","journal-title":"Alzheimers Dement (N. Y)"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib161","first-page":"481","article-title":"Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank","volume":"95","author":"Mak","year":"2024","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib162","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13148-015-0152-7","article-title":"Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients","volume":"7","author":"Maltby","year":"2015","journal-title":"Clin. Epigenetics"},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib163","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ncb2081","article-title":"Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites","volume":"12","author":"Martinez","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib164","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.201610111","article-title":"Telomere-driven diseases and telomere-targeting therapies","volume":"216","author":"Mart\u00ednez","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.arr.2025.102930_bib165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fncel.2020.00016","article-title":"Cellular senescence in neurodegenerative diseases","volume":"14","author":"Mart\u00ednez-Cu\u00e9","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib166","first-page":"193","article-title":"Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson's Disease: The ICICLE-PD Study","volume":"10","author":"Martin-Ruiz","year":"2020","journal-title":"J. Park. Dis."},{"issue":"1 Pt B","key":"10.1016\/j.arr.2025.102930_bib167","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.imlet.2014.06.003","article-title":"Double negative (CD19+IgG+IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients","volume":"162","author":"Martorana","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.arr.2025.102930_bib168","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbi.2016.02.002","article-title":"Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field","volume":"54","author":"Mathur","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib169","doi-asserted-by":"crossref","first-page":"C565","DOI":"10.1152\/ajpcell.00124.2023","article-title":"The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype","volume":"325","author":"Mebratu","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.arr.2025.102930_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108639","article-title":"Telomere length is associated with HIV infection, methamphetamine use, inflammation, and comorbid disease risk","volume":"221","author":"Mehta","year":"2021","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.arr.2025.102930_bib171","series-title":"Health impact of airborne particulate matter in Northern Lebanon: from a pilot epidemiological study to physico-chemical characterization and toxicological effects assessment","author":"Melki","year":"2017"},{"key":"10.1016\/j.arr.2025.102930_bib172","author":"Meloni","year":"2024","journal-title":"Invest. Markers Accel. Aging Patients Treat. Resist. Depress"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib173","first-page":"242","article-title":"The effects of an intensive lifestyle modification program on sleep and stress disorders","volume":"11","author":"Merrill","year":"2007","journal-title":"J. Nutr. Health Aging"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib174","article-title":"2235\u00e2 Disability and pregnancy in multiple sclerosis: relationships with leukocyte telomere length","volume":"4","author":"Michael","year":"2024","journal-title":"BMJ Neurol. Open"},{"issue":"1-2","key":"10.1016\/j.arr.2025.102930_bib175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mrgentox.2008.09.013","article-title":"Environmental-induced oxidative stress in neurodegenerative disorders and aging","volume":"674","author":"Migliore","year":"2009","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib176","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/glioma.glioma_20_20","article-title":"Mechanisms of telomere maintenance in pediatric brain tumors: Promising targets for therapy\u2013A narrative review","volume":"3","author":"Minasi","year":"2020","journal-title":"Glioma"},{"key":"10.1016\/j.arr.2025.102930_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103084","article-title":"What telomeres teach us about MS","volume":"54","author":"Miner","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib178","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12032-025-02627-2","article-title":"Locking the gates of immortality: targeting alternative lengthening of telomeres (ALT) pathways","volume":"42","author":"Mishra","year":"2025","journal-title":"Med. Oncol."},{"key":"10.1016\/j.arr.2025.102930_bib179","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial dysfunction and oxidative stress in Alzheimer\u2019s disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib180","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1158\/1078-0432.CCR-11-1795","article-title":"Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb","volume":"18","author":"Miyazaki","year":"2012","journal-title":"Clin. Cancer Res"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib181","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.exger.2011.12.005","article-title":"Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study","volume":"47","author":"Mov\u00e9rare-Skrtic","year":"2012","journal-title":"Exp. Gerontol."},{"issue":"_2","key":"10.1016\/j.arr.2025.102930_bib182","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1093\/hmg\/ddi266","article-title":"The first molecular details of ALT in human tumor cells","volume":"14","author":"Muntoni","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"18","key":"10.1016\/j.arr.2025.102930_bib183","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.3390\/ijms21186521","article-title":"Updated understanding of cancer as a metabolic and telomere-driven disease, and proposal for complex personalized treatment, a hypothesis","volume":"21","author":"Muresanu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib184","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jb\/mvq119","article-title":"Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells","volume":"149","author":"Nabetani","year":"2011","journal-title":"J. Biochem."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/genes8050145","article-title":"Epigenetic regulation of telomere maintenance for therapeutic interventions in gliomas","volume":"8","author":"Naderlinger","year":"2017","journal-title":"Genes"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib186","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/stem.3270","article-title":"Telomerase RNA processing: Implications for human health and disease","volume":"38","author":"Nagpal","year":"2020","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib187","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3390\/biomedicines12081890","article-title":"Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment","volume":"12","author":"Nea\u021bu","year":"2024","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib188","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/mutage\/17.6.539","article-title":"The significance of telomerase activation and cellular immortalization in human cancer","volume":"17","author":"Newbold","year":"2002","journal-title":"Mutagenesis"},{"key":"10.1016\/j.arr.2025.102930_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2024.102460","article-title":"Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer","volume":"76","author":"Ng","year":"2024","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-190010","article-title":"Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort","volume":"71","author":"Nudelman","year":"2019","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib191","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019687","article-title":"Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study","volume":"6","author":"O'Donovan","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib192","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.biopsych.2011.01.035","article-title":"Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder","volume":"70","author":"O'Donovan","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib193","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3390\/cancers13051147","article-title":"TERT promoter alterations in glioblastoma: a systematic review","volume":"13","author":"Olympios","year":"2021","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib194","doi-asserted-by":"crossref","DOI":"10.3390\/genes14101913","article-title":"Longitudinal Changes in Mitochondrial DNA Copy Number and Telomere Length in Patients with Parkinson's Disease","volume":"14","author":"Ortega-V\u00e1zquez","year":"2023","journal-title":"Genes (Basel)"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib195","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrm2848","article-title":"Telomeres: protecting chromosomes against genome instability","volume":"11","author":"O'sullivan","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib196","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu. Rev. Genet."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib197","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1007\/s12035-024-03947-6","article-title":"The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases","volume":"61","author":"Papageorgakopoulou","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102930_bib198","first-page":"2024","article-title":"Integrative single-cell analysis of neural stem\/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis","author":"Park","year":"2024","journal-title":"bioRxiv"},{"issue":"22","key":"10.1016\/j.arr.2025.102930_bib199","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1093\/nar\/gkm893","article-title":"and T. Von Zglinicki, DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?","volume":"35","author":"Passos","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib200","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/138920021601150702161250","article-title":"Systemic redox biomarkers in neurodegenerative diseases","volume":"16","author":"Pastore","year":"2015","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib201","first-page":"25","article-title":"The Role of Diazepam in Epigenetics: From the Molecular Level to Clinical Implications","volume":"35","author":"Pathak","year":"2021","journal-title":"Adv. Mind Body Med"},{"issue":"16","key":"10.1016\/j.arr.2025.102930_bib202","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.3390\/ijms25168700","article-title":"Advancements in Telomerase-Targeted Therapies for Glioblastoma: A Systematic Review","volume":"25","author":"Pennisi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102930_bib203","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.811518","article-title":"Molecular mechanisms of immunosenescene and inflammaging: relevance to the immunopathogenesis and treatment of multiple sclerosis","volume":"12","author":"Perdaens","year":"2022","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib204","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pili\u00e9","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"24","key":"10.1016\/j.arr.2025.102930_bib205","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1113\/JP275072","article-title":"The role of declining adaptive homeostasis in ageing","volume":"595","author":"Pomatto","year":"2017","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib206","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13492","article-title":"Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging","volume":"20","author":"Porter","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102930_bib207","series-title":"in Aging","first-page":"119","article-title":"Age-related disease: immune system","author":"de Punder","year":"2024"},{"issue":"15","key":"10.1016\/j.arr.2025.102930_bib208","first-page":"11656","article-title":"Microglia specific alternative splicing alterations in multiple sclerosis","volume":"16","author":"Qi","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2025.102930_bib209","article-title":"Decline of hippocampal TRF2 during aging triggers ATM-dependent memory impairment","author":"Raffaelli","year":"2024","journal-title":"Univ. \u00e9 C. \u00f4te D. 'Azur"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib210","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/sctm.18-0045","article-title":"Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis","volume":"7","author":"Redondo","year":"2018","journal-title":"Stem Cells Transl. Med"},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib211","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/1352458517711276","article-title":"Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro","volume":"24","author":"Redondo","year":"2018","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib212","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/ajcn\/86.5.1420","article-title":"Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women","volume":"86","author":"Richards","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib213","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41580-020-0234-z","article-title":"Regulation of human telomerase in homeostasis and disease","volume":"21","author":"Roake","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2025.102930_bib214","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1016\/j.csbj.2022.08.006","article-title":"Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy","volume":"20","author":"Rodr\u00edguez-Fern\u00e1ndez","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib215","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13195-022-01101-9","article-title":"Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study","volume":"14","author":"Rodr\u00edguez-Fern\u00e1ndez","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2025.102930_bib216","article-title":"PERSISTENT DNA DAMAGE AT TELOMERES, CAUSED BY TRF2-MEDIATED DNA REPAIR INHIBITION","author":"Rossiello","year":"2014","journal-title":"TRIGGERS Cell. SENESCENCE IS ASSOCIATED PRIMATES AGEING"},{"key":"10.1016\/j.arr.2025.102930_bib217","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106922","article-title":"Identification of telomere-related genes associated with aging-related molecular clusters and the construction of a diagnostic model in Alzheimer's disease based on a bioinformatic analysis","volume":"159","author":"Ruan","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.arr.2025.102930_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106922","article-title":"Identification of telomere-related genes associated with aging-related molecular clusters and the construction of a diagnostic model in Alzheimer's disease based on a bioinformatic analysis","volume":"159","author":"Ruan","year":"2023","journal-title":"Comput. Biol. Med"},{"issue":"669","key":"10.1016\/j.arr.2025.102930_bib219","doi-asserted-by":"crossref","first-page":"eabq1693","DOI":"10.1126\/scitranslmed.abq1693","article-title":"Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis","volume":"14","author":"Ruder","year":"2022","journal-title":"Sci. Transl. Med"},{"issue":"18","key":"10.1016\/j.arr.2025.102930_bib220","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12185863","article-title":"The Influence of TEP1 and TERC Genetic Variants on the Susceptibility to Multiple Sclerosis","volume":"12","author":"Rum\u0161ait\u0117","year":"2023","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.arr.2025.102930_bib221","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2025.106277","article-title":"Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression: A Mendelian randomization study","volume":"94","author":"Sabaie","year":"2025","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.arr.2025.102930_bib222","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2025.106277","article-title":"Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression: A Mendelian randomization study","volume":"94","author":"Sabaie","year":"2025","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.arr.2025.102930_bib223","article-title":"The association between sleep quality and telomere length: A systematic literature review","volume":"28","author":"Sabot","year":"2023","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.arr.2025.102930_bib224","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111675","article-title":"Cellular senescence in the aging brain: a promising target for neurodegenerative diseases","volume":"204","author":"Sahu","year":"2022","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s40478-016-0364-x","article-title":"Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model","volume":"4","author":"Scheffold","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib226","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s40478-016-0364-x","article-title":"Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model","volume":"4","author":"Scheffold","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib227","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10654-019-00563-w","article-title":"Observational and genetic studies of short telomeres and Alzheimer's disease in 67,000 and 152,000 individuals: a Mendelian randomization study","volume":"35","author":"Scheller Madrid","year":"2020","journal-title":"Eur. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib228","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/ene.12135","article-title":"Telomere length and ischaemic stroke in women: a nested case-control study","volume":"20","author":"Sch\u00fcrks","year":"2013","journal-title":"Eur. J. Neurol."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib229","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/ene.12135","article-title":"Telomere length and ischaemic stroke in women: a nested case\u2013control study","volume":"20","author":"Sch\u00fcrks","year":"2013","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib230","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/10715762.2019.1620939","article-title":"The role of endothelial dysfunction and oxidative stress in cerebrovascular diseases","volume":"53","author":"Scicchitano","year":"2019","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.arr.2025.102930_bib231","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.652497","article-title":"Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a lifetime","volume":"12","author":"Sellami","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.arr.2025.102930_bib232","author":"Selvarajah","year":"2008","journal-title":"Role Break. FusionBridge Mech. osteosarcoma karyotype Evol."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib233","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/jgs.12644","article-title":"Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study","volume":"62","author":"Sen","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib234","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0377-4929.71995","article-title":"Biology of aging brain","volume":"53","author":"Shankar","year":"2010","journal-title":"Indian J. Pathol. Microbiol."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib235","article-title":"Potential roles of telomeres and telomerase in neurodegenerative diseases","volume":"4","author":"Shao","year":"2024","journal-title":"Ageing Neurodegener. Dis."},{"key":"10.1016\/j.arr.2025.102930_bib236","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110631","article-title":"Research progress of small-molecule drugs in targeting telomerase in human cancer and aging","volume":"382","author":"Shen","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib237","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/s43587-021-00146-z","article-title":"Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models","volume":"1","author":"Shim","year":"2021","journal-title":"Nat. Aging"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib238","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/s43587-021-00146-z","article-title":"Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer\u2019s disease models","volume":"1","author":"Shim","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102930_bib239","doi-asserted-by":"crossref","first-page":"1292053","DOI":"10.3389\/fragi.2023.1292053","article-title":"Senescence: A DNA damage response and its role in aging and Neurodegenerative Diseases","volume":"4","author":"Shreeya","year":"2024","journal-title":"Front. Aging"},{"key":"10.1016\/j.arr.2025.102930_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103731","article-title":"Genetically predicted telomere length and multiple sclerosis","volume":"60","author":"Shu","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib241","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.dnarep.2006.05.038","article-title":"The role of DNA damage response proteins at telomeres\u2014an \u201cintegrative\u201d model","volume":"5","author":"Slijepcevic","year":"2006","journal-title":"DNA Repair"},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib242","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuint.2013.02.013","article-title":"Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration","volume":"62","author":"Smith","year":"2013","journal-title":"Neurochem. Int."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib243","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3390\/cancers15071945","article-title":"The molecular mechanisms and therapeutic prospects of alternative lengthening of telomeres (ALT)","volume":"15","author":"Sohn","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.arr.2025.102930_bib244","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fnagi.2017.00194","article-title":"Aging microglia\u2014phenotypes, functions and implications for age-related neurodegenerative diseases","volume":"9","author":"Spittau","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib245","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/cancers12030558","article-title":"Telomeres and telomere length: a general overview","volume":"12","author":"Srinivas","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib246","doi-asserted-by":"crossref","first-page":"16627","DOI":"10.1038\/s41598-018-35122-y","article-title":"Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort","volume":"8","author":"Stefler","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib247","doi-asserted-by":"crossref","first-page":"16627","DOI":"10.1038\/s41598-018-35122-y","article-title":"Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort","volume":"8","author":"Stefler","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib248","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/gerona\/glr185","article-title":"Association Between ApoE Phenotypes and Telomere Erosion in Alzheimer\u2019s Disease","volume":"67A","author":"Takata","year":"2011","journal-title":"J. Gerontol. Ser. A"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib249","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/gerona\/glr185","article-title":"Association between ApoE phenotypes and telomere erosion in Alzheimer's disease","volume":"67","author":"Takata","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib250","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4161\/cc.6.3.3835","article-title":"Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase","volume":"6","author":"Tanaka","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.arr.2025.102930_bib251","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149202","article-title":"Proteostasis disruption and senescence in Alzheimer's disease pathways to neurodegeneration","volume":"1845","author":"Thapa","year":"2024","journal-title":"Brain Res"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib252","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.2217\/epi-2019-0102","article-title":"Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis","volume":"11","author":"Theodoropoulou","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.arr.2025.102930_bib253","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3389\/fneur.2019.00624","article-title":"Telomere length: a potential biomarker for the risk and prognosis of stroke","volume":"10","author":"Tian","year":"2019","journal-title":"Front. Neurol."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib254","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41591-023-02296-6","article-title":"Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality","volume":"29","author":"Tian","year":"2023","journal-title":"Nat. Med"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282363","article-title":"Telomere length and brain imaging phenotypes in UK Biobank","volume":"18","author":"Topiwala","year":"2023","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib256","doi-asserted-by":"crossref","DOI":"10.3390\/nu9060601","article-title":"Alpha- and Gamma-Tocopherol and Telomere Length in 5768 US Men and Women: A NHANES Study","volume":"9","author":"Tucker","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib257","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/1352458512451510","article-title":"Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis","volume":"19","author":"Tutuncu","year":"2013","journal-title":"Mult. Scler."},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib258","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopsych.2009.08.014","article-title":"Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging","volume":"67","author":"Tyrka","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2025.102930_bib259","first-page":"e146","article-title":"Heart disease and stroke statistics\u20132017 update","volume":"135","author":"Update","year":"2017","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib260","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/ijnp\/pyx001","article-title":"Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging","volume":"20","author":"Vasconcelos-Moreno","year":"2017","journal-title":"Int J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib261","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.celrep.2016.09.062","article-title":"Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation","volume":"17","author":"Vera","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2025.102930_bib262","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ebiom.2017.03.027","article-title":"Telomeres and cell senescence-size matters not","volume":"21","author":"Victorelli","year":"2017","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.arr.2025.102930_bib263","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/cancers13030479","article-title":"The interactions of DNA repair, telomere homeostasis, and p53 mutational status in solid cancers: risk, prognosis, and prediction","volume":"13","author":"Vodicka","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.arr.2025.102930_bib264","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.thromres.2023.01.031","article-title":"Association of telomere length and mitochondrial DNA copy number, two biomarkers of biological aging, with the risk of venous thromboembolism","volume":"223","author":"Vostatek","year":"2023","journal-title":"Thromb. Res"},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib265","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1021\/acs.est.8b07141","article-title":"Exposure to environmental pollutants and their association with biomarkers of aging: a multipollutant approach","volume":"53","author":"Vriens","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"40","key":"10.1016\/j.arr.2025.102930_bib266","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.2174\/1381612825666190115121018","article-title":"Oxidative stress and accelerated aging in neurodegenerative and neuropsychiatric disorder","volume":"24","author":"Wadhwa","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib267","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2005.08.021","article-title":"Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis","volume":"122","author":"Wagers","year":"2005","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.arr.2025.102930_bib268","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.mad.2012.05.002","article-title":"Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance","volume":"133","author":"Walker","year":"2012","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib269","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41392-022-01211-8","article-title":"Epigenetic regulation of aging: implications for interventions of aging and diseases","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2025.102930_bib270","article-title":"Accelerated biological aging increases the risk of short- and long-term stroke prognosis in patients with ischemic stroke or","volume":"111","author":"Wang","year":"2025","journal-title":"Tia. EBioMedicine"},{"key":"10.1016\/j.arr.2025.102930_bib271","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.719538","article-title":"Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke","volume":"13","author":"Wang","year":"2021","journal-title":"Front Aging Neurosci."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib272","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1007\/s00204-024-03768-5","article-title":"The role of cellular senescence in neurodegenerative diseases","volume":"98","author":"Wang","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib273","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1089\/neu.2019.6890","article-title":"Damage mechanisms to oligodendrocytes and white matter in central nervous system injury: the Australian context","volume":"37","author":"Warnock","year":"2020","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.arr.2025.102930_bib274","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12603-010-0275-7","article-title":"Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease","volume":"15","author":"Watfa","year":"2011","journal-title":"J. Nutr. Health Aging"},{"issue":"23","key":"10.1016\/j.arr.2025.102930_bib275","doi-asserted-by":"crossref","first-page":"e2355","DOI":"10.1212\/WNL.0000000000207909","article-title":"Measures of Aging Biology in Saliva and Blood as Novel Biomarkers for Stroke and Heart Disease in Older Adults","volume":"101","author":"Waziry","year":"2023","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib276","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/ATVBAHA.110.205492","article-title":"Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk","volume":"30","author":"Willeit","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"s1","key":"10.1016\/j.arr.2025.102930_bib277","doi-asserted-by":"crossref","first-page":"S429","DOI":"10.3233\/JAD-220203","article-title":"DNA damage response-associated cell cycle re-entry and neuronal senescence in brain aging and Alzheimer\u2019s disease","volume":"94","author":"Wong","year":"2023","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib278","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-biochem-061516-045019","article-title":"Telomerase mechanism of telomere synthesis","volume":"86","author":"Wu","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"20","key":"10.1016\/j.arr.2025.102930_bib279","doi-asserted-by":"crossref","first-page":"20483","DOI":"10.18632\/aging.103878","article-title":"Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease","volume":"12","author":"Wu","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.arr.2025.102930_bib280","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41580-024-00775-3","article-title":"Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases","volume":"25","author":"Wu","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.arr.2025.102930_bib281","article-title":"The telomere length of peripheral blood cells is associated with the risk of ischemic stroke in Han population of northern China","volume":"98","author":"Xiao","year":"2019","journal-title":"Med. (Baltim. )"},{"issue":"11","key":"10.1016\/j.arr.2025.102930_bib282","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.3390\/ijms23115877","article-title":"Current and future biomarkers in multiple sclerosis","volume":"23","author":"Yang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102930_bib283","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105498","article-title":"Senescence marker p16INK4a expression in patients with multiple sclerosis","volume":"84","author":"Yang","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"10","key":"10.1016\/j.arr.2025.102930_bib284","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1080\/15548627.2025.2493455","article-title":"METTL3-dependent m(6)A modification of SNAP29 induces \"autophagy-mitochondrial crisis\" in the ischemic microenvironment after soft tissue transplantation","volume":"21","author":"Yang","year":"2025","journal-title":"Autophagy"},{"issue":"_1","key":"10.1016\/j.arr.2025.102930_bib285","article-title":"Abstract TMP57: The Influence of Telomere Length on Ischemic Stroke Risk and Phenotype","volume":"51","author":"Yetim","year":"2020","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib286","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1038\/s41598-021-90435-9","article-title":"The association between telomere length and ischemic stroke risk and phenotype","volume":"11","author":"Yetim","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib287","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s11033-024-10063-0","article-title":"The expression of shelterin genes and telomere repeat analysis and their effect on Alzheimer's disease","volume":"51","author":"Y\u0131lmaz","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib288","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s11033-024-10063-0","article-title":"The expression of shelterin genes and telomere repeat analysis and their effect on Alzheimer\u2019s disease","volume":"51","author":"Y\u0131lmaz","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.arr.2025.102930_bib289","article-title":"Plasma circulating cell-free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson's disease and multiple system atrophy: a cross-sectional study","author":"Ying","year":"2024","journal-title":"Neural Regen. Res"},{"issue":"22","key":"10.1016\/j.arr.2025.102930_bib290","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.3390\/nu16223830","article-title":"Immune Alterations with Aging: Mechanisms and Intervention Strategies","volume":"16","author":"Yu","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102930_bib291","doi-asserted-by":"crossref","first-page":"1165632","DOI":"10.3389\/fimmu.2023.1165632","article-title":"Telomerase reverse transcriptase and neurodegenerative diseases","volume":"14","author":"Yu","year":"2023","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.arr.2025.102930_bib292","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1200\/JCO.2009.25.5463","article-title":"Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets","volume":"28","author":"Zarghooni","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.arr.2025.102930_bib293","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.810572","article-title":"A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma","volume":"13","author":"Zeng","year":"2022","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.arr.2025.102930_bib294","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1161\/STROKEAHA.122.041126","article-title":"Independent and Joint Association of Leukocyte Telomere Length and Lifestyle Score With Incident Stroke","volume":"54","author":"Zhang","year":"2023","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib295","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13578-020-00391-6","article-title":"Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks","volume":"10","author":"Zhang","year":"2020","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib296","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/CS20120691","article-title":"Short telomere length in blood leucocytes contributes to the presence of atherothrombotic stroke and haemorrhagic stroke and risk of post-stroke death","volume":"125","author":"Zhang","year":"2013","journal-title":"Clin. Sci. (Lond. )"},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib297","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/17474930221096552","article-title":"Telomere length and stroke recurrence after ischemic stroke and TIA","volume":"18","author":"Zhang","year":"2023","journal-title":"Int J. Stroke"},{"key":"10.1016\/j.arr.2025.102930_bib298","doi-asserted-by":"crossref","first-page":"1321246","DOI":"10.3389\/fnins.2023.1321246","article-title":"Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study","volume":"17","author":"Zhang","year":"2023","journal-title":"Front Neurosci."},{"issue":"2","key":"10.1016\/j.arr.2025.102930_bib299","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24751","article-title":"The molecular mechanism of aging and the role in neurodegenerative diseases","volume":"10","author":"Zhao","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.arr.2025.102930_bib300","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2022.867950","article-title":"T-cell aging-associated phenotypes in autoimmune disease","volume":"3","author":"Zhao","year":"2022","journal-title":"Front. Aging"},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib301","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nrm1443","article-title":"Apoptosis and genomic instability","volume":"5","author":"Zhivotovsky","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2025.102930_bib302","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105607","article-title":"Leukocyte telomere length in multiple sclerosis: relationship between disability severity and pregnancy history","volume":"86","author":"Zhong","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"9","key":"10.1016\/j.arr.2025.102930_bib303","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.stem.2024.06.007","article-title":"Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening","volume":"31","author":"Zhou","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2025.102930_bib304","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10522-018-9769-1","article-title":"Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction","volume":"20","author":"Zhu","year":"2019","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib305","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12993-021-00179-9","article-title":"Molecular and cellular pathways contributing to brain aging","volume":"17","author":"Zia","year":"2021","journal-title":"Behav. Brain Funct."},{"issue":"1","key":"10.1016\/j.arr.2025.102930_bib306","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1566524021666210218112616","article-title":"The roles of mitochondrial dysfunction and reactive oxygen species in aging and senescence","volume":"22","author":"Zia","year":"2022","journal-title":"Curr. Mol. Med."},{"issue":"18","key":"10.1016\/j.arr.2025.102930_bib307","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.3390\/ijms20184472","article-title":"Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments","volume":"20","author":"Zuo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102930_bib308","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104179","article-title":"Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age","volume":"82","author":"Zuroff","year":"2022","journal-title":"EBioMedicine"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:48:43Z","timestamp":1765385323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725002764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":308,"alternative-id":["S1568163725002764"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102930","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the causal relationship between telomere regulation, aging and neurological disorders","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102930"}}