{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:05:08Z","timestamp":1778594708312,"version":"3.51.4"},"reference-count":377,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.arr.2025.102935","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:00:20Z","timestamp":1762362020000},"page":"102935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The potential of marine-derived compounds in geroscience"],"prefix":"10.1016","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-5171","authenticated-orcid":false,"given":"Maria Elisa","family":"Giuliani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmarco","family":"Bertoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Francini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Bigossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Marcozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunday Segun","family":"Alimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Perini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Piccinini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ristori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bientinesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Cardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Indiveri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariafrancesca","family":"Scalise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Malavolta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2025.102935_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101985","article-title":"TFEB is a central regulator of the aging process and age-related diseases","volume":"89","author":"Abokyi","year":"2023","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1164\/rccm.200406-735OC","article-title":"Airway responses to aerosolized brevetoxins in an animal model of asthma","volume":"171","author":"Abraham","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.arr.2025.102935_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102935_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/md21030193","article-title":"Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry","volume":"21","author":"Akram","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13103","article-title":"Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function","volume":"19","author":"Alibhai","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102935_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/fsn3.3133","article-title":"Effect of seaweed (Ecklonia cava extract) on blood glucose and insulin level on prediabetic patients: A double-blind randomized controlled trial","volume":"11","author":"Almutairi","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/md18070364","article-title":"Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells","volume":"18","author":"Alvarin\u00f5","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102935_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2025.102935_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3661866","article-title":"Bioactive Compounds and Therapeutics from Fish: Revisiting Their Suitability in Functional Foods to Enhance Human Wellbeing","volume":"2022","author":"Awuchi","year":"2022","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.arr.2025.102935_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010496","article-title":"Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation","volume":"5","author":"Bachstetter","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2025.102935_bib12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0022-3565(24)34938-9","article-title":"Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage\/chondrocyte cultures by the natural product, hymenialdisine","volume":"290","author":"Badger","year":"1999","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.arr.2025.102935_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.tiv.2012.11.001","article-title":"Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2\/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells","volume":"27","author":"Bae","year":"2013","journal-title":"Tox Vitr."},{"key":"10.1016\/j.arr.2025.102935_bib14","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1158\/1078-0432.CCR-22-0618","article-title":"FDA Approval Summary: Belantamab Mafodotin for Patients with Relapsed or Refractory Multiple Myeloma","volume":"28","author":"Baines","year":"2022","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.arr.2025.102935_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jsfa.7131","article-title":"The effect of astaxanthin on the aging rat brain: Gender-related differences in modulating inflammation","volume":"96","author":"Balietti","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.arr.2025.102935_bib16","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1111\/jcmm.13192","article-title":"Age-dependent alterations in osteoblast and osteoclast activity in human cancellous bone","volume":"21","author":"Becerikli","year":"2017","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.arr.2025.102935_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12860-016-0120-x","article-title":"Gap junctions and hemichannels: Communicating cell death in neurodevelopment and disease","volume":"18","author":"Belousov","year":"2017","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.arr.2025.102935_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13061400","article-title":"Cancer and aging: Two tightly interconnected biological processes","volume":"13","author":"Berben","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2025.102935_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jbmr.5650110504","article-title":"Age-related changes in osteogenic stem cells in mice","volume":"11","author":"Bergman","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2025.102935_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10637-006-7773-9","article-title":"Trabectedin (ET-743, YondelisTM) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype","volume":"25","author":"Beumer","year":"2007","journal-title":"Invest N. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cub.2016.04.016","article-title":"Gut Microbiota and Extreme Longevity","volume":"26","author":"Biagi","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2025.102935_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102616","article-title":"Hallmarks of aging: A user\u2019s guide for comparative biologists","volume":"104","author":"Biga","year":"2025","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2013.12.006","article-title":"Telomerase activation: A potential key modulator for human healthspan and longevity","volume":"15","author":"Boccardi","year":"2014","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.exger.2009.05.001","article-title":"Marine invertebrates as models for aging research","volume":"44","author":"Bodnar","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102935_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/07924259.2014.938195","article-title":"Cellular and molecular mechanisms of negligible senescence: Insight from the sea urchin","volume":"59","author":"Bodnar","year":"2015","journal-title":"Invertebr. Reprod. Dev."},{"key":"10.1016\/j.arr.2025.102935_bib26","article-title":"Marine collagen hydrolysates promote collagen synthesis, viability and proliferation while downregulating the synthesis of pro-catabolic markers in human articular chondrocytes","volume":"22","author":"Bourdon","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib27","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1210\/jc.2011-3020","article-title":"Age-related changes in thyroid function: A longitudinal study of a community-based cohort","volume":"97","author":"Bremner","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2025.102935_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102132","article-title":"Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging","volume":"92","author":"Brochard","year":"2023","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.47853\/FAS.2023.e34","article-title":"Effect of fermented sarco oyster extract on age induced sarcopenia muscle repair by modulating regulatory T cells","volume":"26","author":"Byun","year":"2023","journal-title":"Fish. Aquat. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib30","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1016\/j.bmc.2017.06.029","article-title":"Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase","volume":"25","author":"Cadelis","year":"2017","journal-title":"Bioorg. Med Chem."},{"key":"10.1016\/j.arr.2025.102935_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.arr.2025.102935_bib32","doi-asserted-by":"crossref","unstructured":"Cappello, E., Nieri, P., 2021. From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial 1\u201319.","DOI":"10.3390\/life11121390"},{"key":"10.1016\/j.arr.2025.102935_bib33","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/clinem\/dgad225","article-title":"Hormones and Aging: An Endocrine Society Scientific Statement","volume":"108","author":"Cappola","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2025.102935_bib34","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/acecec","article-title":"Assessing non-synthetic crosslinkers in biomaterial inks based on polymers of marine origin to increase the shape fidelity in 3D extrusion printing","volume":"18","author":"Carvalho","year":"2023","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.arr.2025.102935_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00414","article-title":"Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration","volume":"8","author":"Cattelan","year":"2020","journal-title":"Front Bioeng. Biotechnol."},{"issue":"46","key":"10.1016\/j.arr.2025.102935_bib36","first-page":"938","article-title":"Chronic obstructive pulmonary disease among adults-United States, 2011","volume":"61","author":"Centers for Disease Control and Prevention (CDC)","year":"2012","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.arr.2025.102935_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06654-8","article-title":"TGF-\u03b2-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure","volume":"9","author":"Chakravarthy","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102935_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/jpbs.jpbs_50_23","article-title":"Bixin and fuxoxanthin alone and in combination with cisplatin regulate ABCC1 and ABCC2 Transcription in A549 Lung Cancer Cells","volume":"15","author":"Chandra","year":"2023","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.arr.2025.102935_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2017.11.022","article-title":"Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1\/AMPK signaling pathway","volume":"495","author":"Chang","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.arr.2025.102935_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.103907","article-title":"A novel antioxidant peptide purified from defatted round scad (Decapterus maruadsi) protein hydrolysate extends lifespan in Caenorhabditis elegans","volume":"68","author":"Chen","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s42995-023-00168-z","article-title":"Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis","volume":"5","author":"Chen","year":"2023","journal-title":"Mar. Life Sci. Technol."},{"key":"10.1016\/j.arr.2025.102935_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2023.100836","article-title":"Antioxidant characteristics of hydrolysate from low-value sea cucumber: In vitro and in vivo activities of Caenorhabditis elegans","volume":"19","author":"Chen","year":"2023","journal-title":"Food Chem. X"},{"key":"10.1016\/j.arr.2025.102935_bib43","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1039\/C9FO01414D","article-title":"Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster","volume":"11","author":"Chen","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2025.102935_bib44","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2022.11768","article-title":"Fucoxanthin ameliorates oxidative injury and inflammation of human bronchial epithelial cells induced by cigarette smoke extract via the PPAR\u03b3\/NF \u03baB signaling pathway","volume":"25","author":"Chen","year":"2022","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.arr.2025.102935_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/md19020114","article-title":"Cytoprotective potential of fucoxanthin in oxidative stress-induced age-related macular degeneration and retinal pigment epithelial cell senescence In Vivo and In Vitro","volume":"19","author":"Chen","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib46","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.biopha.2018.04.121","article-title":"Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages","volume":"103","author":"Choi","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.arr.2014.12.003","article-title":"Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases","volume":"23","author":"Chondrogianni","year":"2015","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib48","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/jcb.24792","article-title":"Effect of age on regulation of human osteoclast differentiation","volume":"115","author":"Chung","year":"2014","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.arr.2025.102935_bib49","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.3390\/md13085358","article-title":"Proteins and carbohydrates from red seaweeds: Evidence for beneficial effects on gut function and microbiota","volume":"13","author":"Cian","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib50","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib51","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1182\/blood-2002-07-2236","article-title":"Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia","volume":"101","author":"Colomer","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.arr.2025.102935_bib52","article-title":"Marine-derived secondary metabolites as promising epigenetic bio-compounds for anticancer therapy","volume":"19","author":"Conte","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2025.102935_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103679","article-title":"Molecular basis of bone aging","volume":"21","author":"Corrado","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0960-894X(96)00142-4","article-title":"A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli","volume":"6","author":"Coval","year":"1996","journal-title":"Bioorg. Med Chem. Lett."},{"key":"10.1016\/j.arr.2025.102935_bib56","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2025.102935_bib57","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1159\/000495922","article-title":"Coccomyxa gloeobotrydiformis polysaccharide inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophages","volume":"51","author":"Dai","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.arr.2025.102935_bib58","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/np400633m","article-title":"Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia","volume":"77","author":"Daletos","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.arr.2025.102935_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/md22030114","article-title":"Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies","volume":"22","author":"Dalisay","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12071480","article-title":"Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review","volume":"12","author":"Davan","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2025.102935_bib61","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/acel.12586","article-title":"Disruption of the Cx43\/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging","volume":"16","author":"Davis","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102935_bib62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De Cecco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.909566","article-title":"From seaside to bedside: Current evidence and future perspectives in the treatment of breast cancer using marine compounds","volume":"13","author":"De Sanctis","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/md16090299","article-title":"Antihypertensive effects of two novel angiotensin I-converting enzyme (ace) inhibitory peptides from Gracilariopsis lemaneiformis (Rhodophyta) in spontaneously hypertensive rats (SHRs)","volume":"16","author":"Deng","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib65","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-007-5416-4_14","article-title":"Alzheimer\u2019s disease","author":"De-Paula","year":"2012","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.arr.2025.102935_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4933-5-11","article-title":"Immunity, ageing and cancer","volume":"5","author":"Derhovanessian","year":"2008","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.arr.2025.102935_bib67","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40265-020-01464-z","article-title":"Lonafarnib: First Approval","volume":"81","author":"Dhillon","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12769-7","article-title":"A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model","volume":"7","author":"Dhinaut","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13050966","article-title":"Response and toxicity to cytarabine therapy in leukemia and lymphoma: From dose puzzle to pharmacogenomic biomarkers","volume":"13","author":"Di Francia","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2025.102935_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11112115","article-title":"Astaxanthin Induces Transcriptomic Responses Associated with Lifespan Extension in Caenorhabditis elegans","volume":"11","author":"Ding","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2025.102935_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101038","article-title":"Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment","volume":"64","author":"Dorling","year":"2020","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.arr.2025.102935_bib73","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/cts.12366","article-title":"ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression","volume":"9","author":"Drenberg","year":"2016","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib74","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1158\/0008-5472.CAN-16-2548","article-title":"OCTN1 is a high-affinity carrier of nucleoside analogues","volume":"77","author":"Drenberg","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.arr.2025.102935_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/md18100514","article-title":"Marine Antithrombotics","volume":"18","author":"Dwivedi","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/md18090482","article-title":"Blue-print autophagy in 2020: a critical review","volume":"18","author":"Dyshlovoy","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/md20120759","article-title":"Marine compounds and cancer: updates 2022","volume":"20","author":"Dyshlovoy","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib78","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.clnu.2016.07.004","article-title":"Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clinical trial","volume":"36","author":"Ebrahimi-Mameghani","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib79","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1016\/j.bmc.2013.04.025","article-title":"Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo","volume":"21","author":"Eguchi","year":"2013","journal-title":"Bioorg. Med Chem."},{"key":"10.1016\/j.arr.2025.102935_bib80","doi-asserted-by":"crossref","first-page":"J49","DOI":"10.1093\/eurheartj\/suaa118","article-title":"The journey of omega-3 fatty acids in cardiovascular medicine","volume":"22","author":"Ferrari","year":"2020","journal-title":"Eur. Heart J. Suppl."},{"key":"10.1016\/j.arr.2025.102935_bib81","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2025.102935_bib82","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3247528","article-title":"Antioxidant, immunomodulating, and microbial-modulating activities of the sustainable and ecofriendly spirulina","volume":"2017","author":"Finamore","year":"2017","journal-title":"Oxid. Med Cell Longev."},{"issue":"1979","key":"10.1016\/j.arr.2025.102935_bib83","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span-from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102935_bib84","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12674","article-title":"\u03a4elomerase inhibitors and activators in aging and cancer: a systematic review","volume":"25","author":"Fragkiadaki","year":"2022","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.arr.2025.102935_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib86","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2025.102935_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00061","article-title":"The continuum of aging and age-related diseases: Common mechanisms but different rates","author":"Franceschi","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.arr.2025.102935_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137115","article-title":"Possible Role of Tauroursodeoxycholic Acid (TUDCA) and Antibiotic Administration in Modulating Human Gut Microbiota in Home Enteral Nutrition Therapy for the Elderly: A Case Report","volume":"25","author":"Francini","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26041759","article-title":"Bi-directional relationship between bile acids (bas) and gut microbiota (GM): UDCA\/TUDCA, probiotics, and dietary interventions in elderly people","volume":"26","author":"Francini","year":"2025","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib90","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/rej.2020.2355","article-title":"Autophagy Plays a Role in the Prolongation of the Life Span of Caenorhabditis elegans by Astaxanthin","volume":"24","author":"Fu","year":"2021","journal-title":"Rejuvenation Res"},{"key":"10.1016\/j.arr.2025.102935_bib91","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/1028415X.2022.2055376","article-title":"Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism","volume":"26","author":"Fu","year":"2023","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.arr.2025.102935_bib92","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4020-9063-9","author":"Fulop","year":"2009","journal-title":"Handb. immunosenescence Basic Underst. Clin. Appl. Handb. Immunosenescence Basic Underst. Clin. Appl."},{"key":"10.1016\/j.arr.2025.102935_bib93","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41573-023-00877-1","article-title":"Membrane transporters in drug development and as determinants of precision medicine","volume":"23","author":"Galetin","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.arr.2025.102935_bib94","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s43587-021-00121-8","article-title":"Strategies for targeting senescent cells in human disease","volume":"1","author":"Gasek","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102935_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/md22050210","article-title":"Marine compounds and age-related diseases: the path from pre-clinical research to approved drugs for the treatment of cardiovascular diseases and diabetes","volume":"22","author":"Giuliani","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib96","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/hmg\/ddi326","article-title":"Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition","volume":"14","author":"Glynn","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.arr.2025.102935_bib97","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000488943","article-title":"The Aging Process Alters IL-1\u03b2 and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid","volume":"25","author":"Gomes De Andrade","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.arr.2025.102935_bib98","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2013.12.028","article-title":"Progeria: A paradigm for translational medicine","volume":"156","author":"Gordon","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10091938","article-title":"Osteoarthritis: Novel molecular mechanisms increase our understanding of the disease pathology","volume":"10","author":"Gr\u00e4ssel","year":"2021","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.arr.2025.102935_bib100","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-015-9831-8","article-title":"Age-related cellular changes in the long-lived bivalve A. islandica","volume":"37","author":"Gruber","year":"2015","journal-title":"Age (Omaha)"},{"key":"10.1016\/j.arr.2025.102935_bib101","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1039\/D0FO00560F","article-title":"Antioxidant and anti-aging effects of a sea cucumber protein hydrolyzate and bioinformatic characterization of its composing peptides","volume":"11","author":"Guo","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2025.102935_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/md20060349","article-title":"Natural Marine Products: Anti-Colorectal Cancer In Vitro and In Vivo","volume":"20","author":"Han","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib103","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jff.2019.04.065","article-title":"Thelenota ananas saponin extracts attenuate the atherosclerosis in apoE\u2212\/\u2212 mice by modulating lipid metabolism","volume":"58","author":"Han","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/md22110496","article-title":"Marine-derived bioactive ingredients in functional foods for aging: nutritional and therapeutic perspectives","volume":"22","author":"Han","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2020.09.060","article-title":"Aging, frailty, and the microbiome\u2014how dysbiosis influences human aging and disease","volume":"160","author":"Haran","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arr.2025.102935_bib106","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11357-023-01011-0","article-title":"Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used","volume":"46","author":"Harrison","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2025.102935_bib107","first-page":"1","article-title":"Microorganisms associated with the marine sponge Scopalina hapalia: A reservoir of bioactive molecules to slow down the aging process","volume":"8","author":"Hassane","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.arr.2025.102935_bib108","article-title":"Cardiac ageing: from hallmarks to therapeutic opportunities","author":"Hastings","year":"2024","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arr.2025.102935_bib109","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature08937","article-title":"Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota","volume":"464","author":"Hehemann","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib110","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejphar.2009.05.017","article-title":"Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent \u03b1-glucosidase and \u03b1-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice","volume":"615","author":"Heo","year":"2009","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib111","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1099\/0022-1317-51-5-448","article-title":"Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection","volume":"51","author":"Hopkins","year":"2002","journal-title":"J. Med Microbiol"},{"key":"10.1016\/j.arr.2025.102935_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/md21010043","article-title":"Application of Marine Natural Products against Alzheimer\u2019s Disease: Past, Present and Future","volume":"21","author":"Hu","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112614","article-title":"The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations \u2013 A narrative review","volume":"197","author":"Huang","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102935_bib114","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113210","article-title":"Reversibility of sarcopenia by Ishige okamurae and its active derivative diphloroethohydroxycarmalol in female aging mice","volume":"152","author":"Hyun","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102935_bib116","doi-asserted-by":"crossref","first-page":"12834","DOI":"10.1073\/pnas.1210121109","article-title":"Erratum: Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells (Proceedings of the National Academy of Sciences (2012) 109, (9071-9076) DOI: 10.1073\/pnas. 1120358109)","volume":"109","author":"Ishikawa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102935_bib117","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The GH\/IGF-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1979","key":"10.1016\/j.arr.2025.102935_bib118","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.arr.2025.102935_bib119","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3390\/md13042141","article-title":"Diphlorethohydroxycarmalol inhibits interleukin-6 production by regulating NF-\u03baB, STAT5 and SOCS1 in lipopolysaccharide-stimulated RAW264.7 cells","volume":"13","author":"Kang","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5487\/TR.2017.33.4.325","article-title":"Anti-inflammatory effect of 3-bromo-4,5-dihydroxybenzaldehyde, a component of Polysiphonia morrowii, in vivo and in vitro","volume":"33","author":"Kang","year":"2017","journal-title":"Toxicol. Res"},{"key":"10.1016\/j.arr.2025.102935_bib121","doi-asserted-by":"crossref","DOI":"10.1186\/s43141-021-00290-4","article-title":"Promising bioactive compounds from the marine environment and their potential effects on various diseases","volume":"20","author":"Karthikeyan","year":"2022","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.arr.2025.102935_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101468","article-title":"Autophagy and the hallmarks of aging","volume":"72","author":"Kaushik","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib123","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-\u03baB-Dependent Gene Expression and Organismal Life Span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/md17030184","article-title":"Brevenal, a marine natural product, is anti-inflammatory and an immunomodulator of macrophage and lung epithelial cells","volume":"17","author":"Keeler","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib125","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1248\/bpb.34.1553","article-title":"Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells","volume":"34","author":"Khanal","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.arr.2025.102935_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.95","article-title":"Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1\/5\/8 signaling in human mesenchymal stem cells","volume":"47","author":"Kim","year":"2015","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.arr.2025.102935_bib127","doi-asserted-by":"crossref","first-page":"78570","DOI":"10.1039\/C6RA12724J","article-title":"A marine algal polyphenol, dieckol, attenuates blood glucose levels by Akt pathway in alloxan induced hyperglycemia zebrafish model","volume":"6","author":"Kim","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.arr.2025.102935_bib128","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3390\/md11041087","article-title":"6\u2033-debromohamacanthin A, a bis (indole) alkaloid, inhibits angiogenesis by targeting the VEGFR2-mediated PI3K\/AKT\/mTOR signaling pathways","volume":"11","author":"Kim","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib129","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.16","article-title":"AMPK activators: Mechanisms of action and physiological activities","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.arr.2025.102935_bib130","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.3390\/ijms11125109","article-title":"Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells","volume":"11","author":"Kim","year":"2010","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib131","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.fct.2010.04.002","article-title":"Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells","volume":"48","author":"Kim","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.arr.2025.102935_bib132","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ejphar.2010.09.032","article-title":"Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-\u03baB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages","volume":"649","author":"Kim","year":"2010","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib133","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.taap.2015.03.026","article-title":"Novel anticancer activity of phloroglucinol against breast cancer stem-like cells","volume":"286","author":"Kim","year":"2015","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib134","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1159\/000490615","article-title":"The gut microbiota and healthy aging: a mini-review","volume":"64","author":"Kim","year":"2018","journal-title":"Gerontology"},{"key":"10.1016\/j.arr.2025.102935_bib135","article-title":"Inhibitory effect of astaxanthin on oxidative stress-induced mitochondrial dysfunction-a mini-review","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102935_bib136","doi-asserted-by":"crossref","DOI":"10.3390\/md18110529","article-title":"Diphlorethohydroxycarmalol (DPHC) isolated from the brown alga Ishige okamurae acts on inflammatory myopathy as an inhibitory agent of TNF-\u03b1","volume":"18","author":"Kim","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib137","doi-asserted-by":"crossref","DOI":"10.3390\/md19050266","article-title":"The effects of marine algal polyphenols, phlorotannins, on skeletal muscle growth in C2C12 muscle cells via smad and IGF-1 signaling pathways","volume":"19","author":"Kim","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib138","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.foodchem.2012.02.210","article-title":"Nitric oxide-mediated vasorelaxation effects of anti-angiotensin I-converting enzyme (ACE) peptide from Styela clava flesh tissue and its anti-hypertensive effect in spontaneously hypertensive rats","volume":"134","author":"Ko","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.arr.2025.102935_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112179","article-title":"Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases","volume":"145","author":"Kohandel","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102935_bib140","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/19490976.2018.1494102","article-title":"Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging","volume":"10","author":"Kong","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.arr.2025.102935_bib141","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tiv.2015.12.010","article-title":"Autophagic activity in BC3H1 cells exposed to yessotoxin","volume":"32","author":"Korsnes","year":"2016","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.arr.2025.102935_bib142","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0047-6374(97)00120-6","article-title":"Sponges (Porifera) model systems to study the shift from immortal to senescent somatic cells: The telomerase activity in somatic cells","volume":"100","author":"Koziol","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2025.102935_bib143","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3382\/ps.2014-04200","article-title":"Immunology, health, and disease: Feed supplementation with red seaweeds, Chondrus crispus and Sarcodiotheca gaudichaudii, affects performance, egg quality, and gut microbiota of layer hens","volume":"93","author":"Kulshreshtha","year":"2014","journal-title":"Poult. Sci."},{"issue":"6","key":"10.1016\/j.arr.2025.102935_bib144","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jcb.25053","article-title":"Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K\/AKT\/mTOR signaling cascade in human leukemia HL-60 cells","volume":"116","author":"Kumar","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.arr.2025.102935_bib145","first-page":"161","article-title":"Evaluation of antioxidant, hypolipidemic, and antiatherogenic property of lycopene and astaxanthin in atherosclerosis-induced rats","volume":"9","author":"Kumar","year":"2017","journal-title":"Pharmacogn. Res"},{"key":"10.1016\/j.arr.2025.102935_bib146","doi-asserted-by":"crossref","DOI":"10.3390\/md22030113","article-title":"Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells","volume":"22","author":"Kurera","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111425","article-title":"Deciphering the whale\u2019s secrets to have a long life","volume":"151","author":"Lagunas-Rangel","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102935_bib148","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1016\/j.bmc.2011.09.028","article-title":"9,10-Secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp","volume":"19","author":"Lai","year":"2011","journal-title":"Bioorg. Med Chem."},{"key":"10.1016\/j.arr.2025.102935_bib149","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mrrev.2016.08.002","article-title":"IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome","volume":"772","author":"Laron","year":"2017","journal-title":"Mutat. Res Rev. Mutat. Res"},{"key":"10.1016\/j.arr.2025.102935_bib150","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.phrs.2015.08.009","article-title":"Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans","volume":"100","author":"Lashmanova","year":"2015","journal-title":"Pharm. Res"},{"key":"10.1016\/j.arr.2025.102935_bib151","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1016\/j.bmcl.2017.05.035","article-title":"Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp","volume":"27","author":"Le","year":"2017","journal-title":"Bioorg. Med Chem. Lett."},{"key":"10.1016\/j.arr.2025.102935_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127145","article-title":"Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160","volume":"30","author":"Le","year":"2020","journal-title":"Bioorg. Med Chem. Lett."},{"key":"10.1016\/j.arr.2025.102935_bib153","doi-asserted-by":"crossref","DOI":"10.3390\/md20060365","article-title":"Protein Hydrolysate from Spirulina platensis Prevents Dexamethasone-Induced Muscle Atrophy via Akt\/Foxo3 Signaling in C2C12 Myotubes","volume":"20","author":"Lee","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib154","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yjmcc.2016.05.011","article-title":"Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease","volume":"97","author":"Lee","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.arr.2025.102935_bib155","doi-asserted-by":"crossref","DOI":"10.3390\/md16040121","article-title":"Fucoidan rescues p-cresol-induced cellular senescence in mesenchymal stem cells via FAK-Akt-TWIST axis","volume":"16","author":"Lee","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib156","doi-asserted-by":"crossref","DOI":"10.1186\/s41240-018-0114-z","article-title":"A novel BACE inhibitor isolated from Eisenia bicyclis exhibits neuroprotective activity against \u03b2-amyloid toxicity","volume":"21","author":"Lee","year":"2018","journal-title":"Fish. Aquat. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib157","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12125","article-title":"Pyropia yezoensis protein protects against TNF-\u03b1-induced myotube atrophy in C2C12 myotubes via the NF-\u03baB signaling pathway","volume":"24","author":"Lee","year":"2021","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.arr.2025.102935_bib158","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1039\/C4FO00940A","article-title":"Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: A double-blind, randomized, placebo-controlled clinical trial","volume":"6","author":"Lee","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2025.102935_bib159","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5483\/BMBRep.2013.46.4.033","article-title":"Caloric restriction and its mimetics","volume":"46","author":"Lee","year":"2013","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2025.102935_bib160","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1016\/j.fct.2010.06.032","article-title":"Dieckol isolated from Ecklonia cava inhibits \u03b1-glucosidase and \u03b1-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice","volume":"48","author":"Lee","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.arr.2025.102935_bib161","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fct.2016.02.022","article-title":"Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4","volume":"91","author":"Lee","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.arr.2025.102935_bib162","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3390\/md11051728","article-title":"Extract from the zooxanthellate jellyfish Cotylorhiza tuberculata modulates gap junction intercellular communication in human cell cultures","volume":"11","author":"Leone","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib163","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/jmf.2009.1279","article-title":"Marine collagen peptides prepared from chum salmon (Oncorhynchus keta) skin extend the life span and inhibit spontaneous tumor incidence in Sprague-Dawley rats","volume":"13","author":"Liang","year":"2010","journal-title":"J. Med Food"},{"key":"10.1016\/j.arr.2025.102935_bib164","doi-asserted-by":"crossref","DOI":"10.1038\/srep34564","article-title":"Phycocyanin inhibits tumorigenic potential of pancreatic cancer cells: role of apoptosis and autophagy","volume":"6","author":"Liao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib165","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1404-9","article-title":"Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion","volume":"10","author":"Liao","year":"2019","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2025.102935_bib166","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(03)00889-4","article-title":"Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan","volume":"115","author":"Libina","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib167","doi-asserted-by":"crossref","DOI":"10.3390\/md17080467","article-title":"Marine collagen as a promising biomaterial for biomedical applications","volume":"17","author":"Lim","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib168","article-title":"Potential pharmacological resources: Natural bioactive compounds from marine-derived fungi","volume":"14","author":"Liming","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib169","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jff.2018.05.033","article-title":"Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flies and D-galactose-induced aging mice","volume":"47","author":"Lin","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.103954","article-title":"Preparation of sea cucumber (Stichopus variegates) peptide fraction with desired organoleptic property and its anti-aging activity in fruit flies and D-galactose-induced aging mice","volume":"69","author":"Lin","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/md21100518","article-title":"Antidiabetic effect of collagen peptides from harpadon nehereus bones in streptozotocin-induced diabetes mice by regulating oxidative stress and glucose metabolism","volume":"21","author":"Lin","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib172","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.7150\/thno.78376","article-title":"A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2025.102935_bib173","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cbi.2009.08.017","article-title":"Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication","volume":"182","author":"Liu","year":"2009","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.arr.2025.102935_bib174","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fitote.2013.08.014","article-title":"Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa","volume":"91","author":"Liu","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.arr.2025.102935_bib175","article-title":"C-Phycocyanin Ameliorates the Senescence of Mesenchymal Stem Cells through ZDHHC5-Mediated Autophagy via PI3K\/AKT\/mTOR Pathway","author":"Liu","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2025.102935_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082887","article-title":"Sargassum fusiforme alginate relieves hyperglycemia and modulates intestinal microbiota and metabolites in type 2 diabetic mice","volume":"13","author":"Liu","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102935_bib177","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/acs.jnatprod.2c00990","article-title":"Dihydrotrichodimerol Purified from the Marine Fungus Acremonium citrinum Prevents NAFLD by Targeting PPAR\u03b1","volume":"86","author":"Liu","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.arr.2025.102935_bib178","article-title":"Medical application of Spirulina platensis Derived C-Phycocyanin","volume":"2016","author":"Liu","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.arr.2025.102935_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138415","article-title":"Effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in prediabetes: a randomized controlled trial","volume":"287","author":"Liu","year":"2025","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102935_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155249","article-title":"Astaxanthin alleviates chronic prostatitis\/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine","volume":"123","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arr.2025.102935_bib181","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib182","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib183","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/jmf.2022.0103","article-title":"Effect of fucoxanthin on metabolic syndrome, insulin sensitivity, and insulin secretion","volume":"26","author":"L\u00f3pez-Ramos","year":"2023","journal-title":"J. Med Food"},{"key":"10.1016\/j.arr.2025.102935_bib184","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/cimb44010002","article-title":"Isolation of an extract from the soft coral symbiotic microorganism Salinispora arenicola exerting cytoprotective and anti-aging effects","volume":"44","author":"Louka","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"issue":"9","key":"10.1016\/j.arr.2025.102935_bib185","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/md16090318","article-title":"The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model","volume":"16","author":"Lucena","year":"2018","journal-title":"Marine Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib186","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2009.06.015","article-title":"Fucoidan protects against dopaminergic neuron death in vivo and in vitro","volume":"617","author":"Luo","year":"2009","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib187","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejphar.2017.06.022","article-title":"Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo","volume":"811","author":"Ma","year":"2017","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib188","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ncb0910-842","article-title":"Can autophagy promote longevity?","volume":"12","author":"Madeo","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.arr.2025.102935_bib189","doi-asserted-by":"crossref","DOI":"10.3390\/cells11010100","article-title":"High-content C. elegans screen identifies natural compounds impacting mitochondria-lipid homeostasis and promoting healthspan","volume":"11","author":"Maglioni","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.arr.2025.102935_bib190","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01294-23","article-title":"Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation","volume":"9","author":"Mancabelli","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.arr.2025.102935_bib191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.10.049","article-title":"Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship","volume":"107","author":"Manda","year":"2016","journal-title":"Eur. J. Med Chem."},{"key":"10.1016\/j.arr.2025.102935_bib192","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ejhf.449","article-title":"One-year follow-up results from AUGMENT-HF: a multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure","volume":"18","author":"Mann","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.arr.2025.102935_bib193","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s43587-023-00416-y","article-title":"Targeting the biology of aging with mTOR inhibitors","volume":"3","author":"Mannick","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102935_bib194","doi-asserted-by":"crossref","DOI":"10.3390\/cells12182287","article-title":"Spreading Senescent Cells\u2019 Burden and Emerging Therapeutic Targets for Frailty","volume":"12","author":"Marcozzi","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.arr.2025.102935_bib195","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.arr.2025.102935_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/md16120496","article-title":"Spirulina maxima decreases endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension: Results from exploratory controlled clinical trial","volume":"16","author":"Mart\u00ednez-S\u00e1mano","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib197","doi-asserted-by":"crossref","DOI":"10.3390\/md20070418","article-title":"The marine-derived macrolactone mandelalide a is an indirect activator of AMPK","volume":"20","author":"Mattos","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib198","doi-asserted-by":"crossref","DOI":"10.3390\/md22070309","article-title":"Marine pharmacology in 2019\u20132021: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of A","volume":"22","author":"Mayer","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib199","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.febslet.2008.11.051","article-title":"NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice","volume":"583","author":"Mena","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2025.102935_bib200","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jamda.2013.05.009","article-title":"Proinflammatory cytokines, aging, and age-related diseases","volume":"14","author":"Michaud","year":"2013","journal-title":"J. Am. Med Dir. Assoc."},{"key":"10.1016\/j.arr.2025.102935_bib201","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2015.10.030","article-title":"Role of connexin 43 in cardiovascular diseases","volume":"768","author":"Michela","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib202","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11112929","article-title":"Atheroprotective Effect of Fucoidan in THP-1 Macrophages by Potential Upregulation of ABCA1","volume":"11","author":"Mirza","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.arr.2025.102935_bib203","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02020-z","article-title":"Aging and cancer","volume":"23","author":"Mont\u00e9gut","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.arr.2025.102935_bib204","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021435","article-title":"Marine natural products with activities against prostate cancer: recent discoveries","volume":"24","author":"Montuori","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib205","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1021\/jo071003y","article-title":"Spongolactams, farnesyl transferase inhibitors from a marine sponge: Isolation through an LC\/MS-guided assay, structures, and semisyntheses","volume":"72","author":"Mori","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.arr.2025.102935_bib206","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-018-4471-x","article-title":"Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila","volume":"19","author":"Moskalev","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.arr.2025.102935_bib207","article-title":"Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson\u2019s disease: Possible implications of glial cells","author":"Nagatsu","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.arr.2025.102935_bib208","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-05179-1","article-title":"Inference of long-range cell-cell force transmission from ECM remodeling fluctuations","volume":"6","author":"Nahum","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.arr.2025.102935_bib209","first-page":"1","article-title":"Role of cellular senescence in type II diabetes","volume":"162","author":"Narasimhan","year":"2021","journal-title":"Endocrinol. (U. S. )"},{"key":"10.1016\/j.arr.2025.102935_bib210","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1474-9726.2012.00795.x","article-title":"A senescent cell bystander effect: Senescence-induced senescence","volume":"11","author":"Nelson","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102935_bib211","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12272-017-0890-5","article-title":"Anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungal strain Penicillium sp. SF-5629","volume":"40","author":"Ngan","year":"2017","journal-title":"Arch. Pharm. Res"},{"key":"10.1016\/j.arr.2025.102935_bib212","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a risk factor for disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.arr.2025.102935_bib213","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s40199-019-00273-4","article-title":"Marine anticancer drugs and their relevant targets: a treasure from the ocean","volume":"27","author":"Nigam","year":"2019","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib214","doi-asserted-by":"crossref","DOI":"10.5943\/mycosphere\/8\/1\/10","article-title":"Trypanocidal activity, cytotoxicity and histone modifications induced by malformin A1 isolated from the marine-derived fungus Aspergillus tubingensis IFM 63452","volume":"8","author":"Notarte","year":"2017","journal-title":"Mycosphere"},{"key":"10.1016\/j.arr.2025.102935_bib215","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23010042","article-title":"Fascaplysin sensitizes anti-cancer effects of drugs targeting AKT and AMPK","volume":"23","author":"Oh","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102935_bib216","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/revneuro-2011-0065","article-title":"Glial hemichannels and their involvement in aging and neurodegenerative diseases","volume":"23","author":"Orellana","year":"2012","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.arr.2025.102935_bib217","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045256","article-title":"A Spirulina-Enhanced Diet Provides Neuroprotection in an \u03b1-Synuclein Model of Parkinson\u2019s Disease","volume":"7","author":"Pabon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2025.102935_bib218","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4067162","article-title":"Mitochondrial role in stemness and differentiation of hematopoietic stem cells","volume":"2019","author":"Papa","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arr.2025.102935_bib219","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000100809","article-title":"Induction of apoptosis by (Z)-stellettic acid C, an acetylenic acid from the sponge Stelletta sp., is associated with inhibition of telomerase activity in human leukemic U937 cells","volume":"53","author":"Park","year":"2007","journal-title":"Chemotherapy"},{"key":"10.1016\/j.arr.2025.102935_bib220","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3892\/ijmm.2012.1084","article-title":"Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells","volume":"30","author":"Park","year":"2012","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.arr.2025.102935_bib221","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jphs.2016.03.007","article-title":"Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation","volume":"131","author":"Park","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib222","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/2215083808666220817095619","article-title":"A mini-review on marine bioactive compounds as a source of antiviral drug lead","volume":"9","author":"Parmar","year":"2023","journal-title":"Curr. Tradit. Med."},{"key":"10.1016\/j.arr.2025.102935_bib223","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118763119","article-title":"Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation","volume":"119","author":"Pascual-Torner","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102935_bib224","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2165\/0023210-200923010-00003","article-title":"Getting into the brain: Approaches to enhance brain drug delivery","volume":"23","author":"Patel","year":"2009","journal-title":"CNS Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib225","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1658-3876(09)50005-2","article-title":"Stem cells, DNA damage, ageing and cancer","volume":"2","author":"Pazhanisamy","year":"2009","journal-title":"Hematol. \/ Oncol. Stem Cell Ther."},{"key":"10.1016\/j.arr.2025.102935_bib226","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.01.053","article-title":"Advances in the pathology and treatment of osteoarthritis: The pathology and treatment of osteoarthritis","author":"Peng","year":"2025","journal-title":"J. Adv. Res"},{"key":"10.1016\/j.arr.2025.102935_bib227","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.chembiol.2021.07.017","article-title":"Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1","volume":"29","author":"Persaud","year":"2022","journal-title":"Cell Chem. Biol."},{"issue":"3","key":"10.1016\/j.arr.2025.102935_bib228","first-page":"851","article-title":"The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension","volume":"17","author":"Peto","year":"2025","journal-title":"Aging"},{"key":"10.1016\/j.arr.2025.102935_bib229","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ijc.31664","article-title":"Global cancer incidence in older adults, 2012 and 2035: A population-based study","volume":"144","author":"Pilleron","year":"2019","journal-title":"Int J. Cancer"},{"key":"10.1016\/j.arr.2025.102935_bib230","first-page":"1","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.arr.2025.102935_bib231","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1080\/10408398.2021.2010646","article-title":"Recent advances in industrial applications of seaweeds","volume":"63","author":"Polat","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib232","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66052-3","article-title":"Unique age-related transcriptional signature in the nervous system of the long-lived red sea urchin Mesocentrotus franciscanus","volume":"10","author":"Polinski","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib233","doi-asserted-by":"crossref","DOI":"10.3390\/md20040271","article-title":"Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals","volume":"20","author":"Pradhan","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib234","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11033-019-05102-0","article-title":"Chemical screening identifies an extract from marine Pseudomonas sp.-PTR-08 as an anti-aging agent that promotes fission yeast longevity by modulating the Pap1\u2013ctt1 + pathway and the cell cycle","volume":"47","author":"Prastya","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib235","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.knee.2024.03.002","article-title":"Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis","volume":"48","author":"Qin","year":"2024","journal-title":"Knee"},{"key":"10.1016\/j.arr.2025.102935_bib236","doi-asserted-by":"crossref","DOI":"10.3390\/md22100433","article-title":"Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity","volume":"22","author":"Qiu","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib237","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/ehjqcco\/qcad033","article-title":"Burden of cardiovascular disease among elderly: based on the Global Burden of Disease Study 2019","volume":"10","author":"Qu","year":"2024","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes"},{"key":"10.1016\/j.arr.2025.102935_bib238","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23027","article-title":"Fucoxanthin prevents cell growth and induces apoptosis in endometrial cancer HEC-1A cells by the inhibition of the PI3K\/Akt\/mTOR pathway","volume":"36","author":"Qu","year":"2022","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.arr.2025.102935_bib239","doi-asserted-by":"crossref","DOI":"10.3390\/md15060190","article-title":"The identification of a SIRT6 activator from brown algae Fucus distichus","volume":"15","author":"Rahnasto-Rilla","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib240","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S0007114519002678","article-title":"Laminarin-rich extract improves growth performance, small intestinal morphology, gene expression of nutrient transporters and the large intestinal microbial composition of piglets during the critical post-weaning period","volume":"123","author":"Rattigan","year":"2020","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib241","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and age-related diseases: Role of inflammation triggers and cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.arr.2025.102935_bib242","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cmet.2017.07.019","article-title":"Regulation of stem cell aging by metabolism and epigenetics","volume":"26","author":"Ren","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.arr.2025.102935_bib243","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/14786419.2018.1488699","article-title":"\u03b2-secretase 1 inhibitory activity and AMP-activated protein kinase activation of Callyspongia samarensis extracts","volume":"34","author":"Resuello","year":"2020","journal-title":"Nat. Prod. Res"},{"key":"10.1016\/j.arr.2025.102935_bib244","doi-asserted-by":"crossref","first-page":"8322","DOI":"10.1073\/pnas.0702456104","article-title":"Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential","volume":"104","author":"Retamal","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102935_bib245","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192416450","article-title":"Effect of Fermented Sarco Oyster (Crassostrea gigas) Extract on Muscle Strength Enhancement in Postmenopausal Females: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"19","author":"Rheu","year":"2022","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.arr.2025.102935_bib246","article-title":"Intercellular communication and aging","author":"Ribeiro-Rodrigues","year":"2022","journal-title":"Aging. Fundam. Biol. Soc. Impact"},{"key":"10.1016\/j.arr.2025.102935_bib247","doi-asserted-by":"crossref","DOI":"10.3390\/md20040219","article-title":"Biomaterials and bioactive natural products from marine invertebrates: from basic research to innovative applications","volume":"20","author":"Romano","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib248","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age","volume":"447","author":"Rossi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib249","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cellsig.2013.10.004","article-title":"Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3","volume":"26","author":"Rubiolo","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.arr.2025.102935_bib250","doi-asserted-by":"crossref","DOI":"10.3390\/md16100385","article-title":"New mammalian target of rapamycin (mTOR) modulators derived from natural product databases and marine extracts by using molecular docking techniques","volume":"16","author":"Ruiz-Torres","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib251","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.atherosclerosis.2012.02.002","article-title":"Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels and progression of atherosclerosis in LDLR -\/- and ApoE -\/- mice","volume":"222","author":"Ryu","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arr.2025.102935_bib252","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111091","article-title":"Marine-derived drugs: Recent advances in cancer therapy and immune signaling","volume":"134","author":"Saeed","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102935_bib253","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1080\/07391102.2021.1877822","article-title":"Marine phycocompound screening reveals a potential source of novel senotherapeutics","volume":"40","author":"Salekeen","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.arr.2025.102935_bib254","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib255","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22962-y","article-title":"Taxonomic signatures of cause-specific mortality risk in human gut microbiome","volume":"12","author":"Salosensaari","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102935_bib256","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ijpharm.2016.10.061","article-title":"Hydrogel based approaches for cardiac tissue engineering","volume":"523","author":"Saludas","year":"2017","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.arr.2025.102935_bib257","first-page":"1675","article-title":"Immune system, cell senescence, aging and longevity - inflamm-aging reappraised","volume":"19","author":"Salvioli","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.arr.2025.102935_bib258","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/md6040578","article-title":"Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica","volume":"6","author":"Sangnoi","year":"2008","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib259","doi-asserted-by":"crossref","DOI":"10.3390\/md19120678","article-title":"Anti-inflammatory mechanisms of fucoidans to treat inflammatory diseases: A review","volume":"19","author":"Sanjeewa","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib260","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101422","article-title":"Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?","volume":"71","author":"Santoro","year":"2021","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.arr.2025.102935_bib261","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics9080455","article-title":"From ocean to medicine: Pharmaceutical applications of metabolites from marine bacteria","volume":"9","author":"Santos","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.arr.2025.102935_bib262","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-022-01249-4","article-title":"Effects of caloric restriction on the gut microbiome are linked with immune senescence","volume":"10","author":"Sbierski-Kind","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.arr.2025.102935_bib263","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1470-2045(00)00292-8","article-title":"Marine organisms as a source of new anticancer agents","volume":"2","author":"Schwartsmann","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.arr.2025.102935_bib264","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.3390\/md13117005","article-title":"Phorbaketal A, isolated from the marine sponge Phorbas sp., exerts its anti-inflammatory effects via NF-\u03baB inhibition and heme oxygenase-1 activation in lipopolysaccharide-stimulated macrophages","volume":"13","author":"Seo","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18231\/j.ijcaap.2024.001","article-title":"The role of TGF-\u03b2; in cardiac fibrosis and heart failure: A review","volume":"9","author":"Shah","year":"2024","journal-title":"IP Int. J. Compr. Adv. Pharmacol."},{"key":"10.1016\/j.arr.2025.102935_bib266","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1093\/cvr\/cvad188","article-title":"Do patients benefit from omega-3 fatty acids?","volume":"119","author":"Sherratt","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.arr.2025.102935_bib267","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104462","article-title":"Two novel antioxidant peptides derived from Arca subcrenata against oxidative stress and extend lifespan in Caenorhabditis elegans","volume":"81","author":"Shi","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib268","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108078","article-title":"Diabetes and global ageing among 65\u201399-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"162","author":"Sinclair","year":"2020","journal-title":"Diabetes Res Clin. Pr."},{"key":"10.1016\/j.arr.2025.102935_bib269","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00164-2019","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: The GOLD science committee report 2019","volume":"53","author":"Singh","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.arr.2025.102935_bib270","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1158\/1078-0432.CCR-20-3901","article-title":"FDA approval summary: Lurbinectedin for the treatment of metastatic small cell lung cancer","volume":"27","author":"Singh","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.arr.2025.102935_bib271","article-title":"Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis","author":"Sj","year":"2019","journal-title":"FEMS Yeast Res 19"},{"key":"10.1016\/j.arr.2025.102935_bib272","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000512971","article-title":"Iodine, Seaweed, and the Thyroid","volume":"10","author":"Smyth","year":"2021","journal-title":"Eur. Thyroid J."},{"key":"10.1016\/j.arr.2025.102935_bib273","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.exger.2013.09.007","article-title":"Lifespan extension of rotifers by treatment with red algal extracts","volume":"48","author":"Snare","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2025.102935_bib274","doi-asserted-by":"crossref","DOI":"10.3390\/md18070351","article-title":"Astaxanthin as a putative geroprotector: molecular basis and focus on brain aging","volume":"18","author":"Sorrenti","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib275","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411499121","article-title":"Reverse development in the ctenophore Mnemiopsis leidyi","volume":"121","author":"Soto-Angel","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2025.102935_bib276","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/bcpt.12669","article-title":"Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6-Hydroxydopamine Parkinson\u2019s Disease Model: Behavioural, Neurochemical and Transcriptional Alterations","volume":"120","author":"Souza","year":"2017","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.arr.2025.102935_bib277","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrm3420","article-title":"DNA damage checkpoints in stem cells, ageing and cancer","volume":"13","author":"Sperka","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.arr.2025.102935_bib278","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10522-020-09904-9","article-title":"Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae","volume":"22","author":"Sudharshan","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2025.102935_bib279","doi-asserted-by":"crossref","DOI":"10.3390\/md15120367","article-title":"Three new malyngamides from the marine cyanobacterium Moorea producens","volume":"15","author":"Sueyoshi","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13020379","article-title":"Astaxanthin prevents atrophy in slow muscle fibers by inhibiting mitochondrial reactive oxygen species via a mitochondria-mediated apoptosis pathway","volume":"13","author":"Sun","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102935_bib281","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cbic.200600349","article-title":"Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K\/AKT activation, glucose transport, and TGF\u03b2\/Smad2 signaling","volume":"8","author":"Sun","year":"2007","journal-title":"ChemBioChem"},{"key":"10.1016\/j.arr.2025.102935_bib282","doi-asserted-by":"crossref","first-page":"21660","DOI":"10.3390\/ijms151221660","article-title":"Sterols from mytilidae show anti-aging and neuroprotective effects via anti-oxidative activity","volume":"15","author":"Sun","year":"2014","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib283","doi-asserted-by":"crossref","DOI":"10.3390\/md19030135","article-title":"Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata","volume":"19","author":"Susano","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib284","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49751-5","article-title":"Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K\/Akt\/Nrf-2 pathway","volume":"13","author":"Suwanmanee","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib285","doi-asserted-by":"crossref","first-page":"27477","DOI":"10.1039\/D3RA04843H","article-title":"Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis","volume":"13","author":"Tammam","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.arr.2025.102935_bib286","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115471","article-title":"Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium","volume":"167","author":"Tang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102935_bib287","doi-asserted-by":"crossref","DOI":"10.3390\/md21010052","article-title":"Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial infarction in mice","volume":"21","author":"Tang","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib288","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s43587-022-00231-x","volume":"2","author":"The importance of aging in cancer research","year":"2022","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2025.102935_bib289","doi-asserted-by":"crossref","DOI":"10.3390\/md21070399","article-title":"The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy","volume":"21","author":"Therdyothin","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib290","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10734-y","article-title":"Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients \/692\/700\/1518 \/692\/308\/575 article","volume":"7","author":"Ticinesi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib291","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10522-022-09978-7","article-title":"Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions","volume":"23","author":"Tomtheelnganbee","year":"2022","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2025.102935_bib292","doi-asserted-by":"crossref","DOI":"10.3390\/biom11040521","article-title":"The mitochondrial carnitine acyl-carnitine carrier (Slc25a20): Molecular mechanisms of transport, role in redox sensing and interaction with drugs","volume":"11","author":"Tonazzi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.arr.2025.102935_bib293","doi-asserted-by":"crossref","DOI":"10.1177\/15347354231187153","article-title":"The auxiliary effects of low-molecular-weight fucoidan in locally advanced rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy before surgery: a double-blind, randomized, placebo-controlled Study","volume":"22","author":"Tsai","year":"2023","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.arr.2025.102935_bib294","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3892\/mmr.2020.11284","article-title":"A potential role for astaxanthin in the treatment of bone diseases (Review)","volume":"22","author":"Valenti","year":"2020","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.arr.2025.102935_bib295","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"Van Deursen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.arr.2025.102935_bib296","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.1158\/1078-0432.CCR-09-2127","article-title":"ABCC2, ABCC3, and ABCB1, but not CYP3A, protect against trabectedin-mediated hepatotoxicity","volume":"15","author":"Van Waterschoot","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.arr.2025.102935_bib297","doi-asserted-by":"crossref","DOI":"10.3390\/md16070233","article-title":"Marine carbohydrate-based compounds with medicinal properties","volume":"16","author":"Vasconcelos","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib298","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2017.04.006","article-title":"DNA Damage in Stem Cells","volume":"66","author":"Vitale","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.arr.2025.102935_bib299","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02332-3","article-title":"Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2025.102935_bib300","doi-asserted-by":"crossref","DOI":"10.3390\/md21040226","article-title":"Marine-derived lead fascaplysin: pharmacological activity, total synthesis, and structural modification","volume":"21","author":"Wang","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib301","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2023.103167","article-title":"Porphyran, porphyran oligosaccharides and porphyranase: Source, structure, preparation methods and applications","volume":"73","author":"Wang","year":"2023","journal-title":"Algal Res"},{"key":"10.1016\/j.arr.2025.102935_bib302","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jbmr.4025","article-title":"Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice","volume":"35","author":"Wang","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2025.102935_bib303","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104677","article-title":"High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice","volume":"86","author":"Wang","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib304","article-title":"Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K\/Akt\/mTOR Pathway","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib305","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/1751-2980.13215","article-title":"Effect of fucoidan on gut microbiota and its clinical efficacy in Helicobacter pylori eradication: A randomized controlled trial","volume":"24","author":"Wang","year":"2023","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.arr.2025.102935_bib306","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10571-015-0323-2","article-title":"Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3","volume":"36","author":"Wang","year":"2016","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.arr.2025.102935_bib307","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1523\/JNEUROSCI.0852-11.2011","article-title":"Mitochondrial DNA damage level determines neural stem cell differentiation fate","volume":"31","author":"Wang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2025.102935_bib308","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13018-024-04775-z","article-title":"Astaxanthin-mediated Nrf2 activation ameliorates glucocorticoid-induced oxidative stress and mitochondrial dysfunction and impaired bone formation of glucocorticoid-induced osteonecrosis of the femoral head in rats","volume":"19","author":"Wang","year":"2024","journal-title":"J. Orthop. Surg. Res"},{"key":"10.1016\/j.arr.2025.102935_bib309","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ijbiomac.2019.08.186","article-title":"The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans","volume":"140","author":"Wang","year":"2019","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102935_bib310","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110313","article-title":"Antiaging compounds from marine organisms","volume":"143","author":"Wang","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.arr.2025.102935_bib311","article-title":"Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence","volume":"9","author":"Wang","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib312","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110148","article-title":"Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes","volume":"366","author":"Wang","year":"2022","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.arr.2025.102935_bib313","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1021\/jo0267910","article-title":"Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis","volume":"68","author":"Warabi","year":"2003","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.arr.2025.102935_bib314","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1021\/ja052688r","article-title":"Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula","volume":"127","author":"Warabi","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.arr.2025.102935_bib315","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","article-title":"Mechanisms and consequences of intestinal dysbiosis","volume":"74","author":"Weiss","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.arr.2025.102935_bib316","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/md8041080","article-title":"Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry","volume":"8","author":"Wijesekara","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib317","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.831116","article-title":"The unfolded protein responses in health, aging, and neurodegeneration: recent advances and future considerations","volume":"15","author":"Wodrich","year":"2022","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.arr.2025.102935_bib318","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1021\/acs.jnatprod.7b00651","article-title":"Polyoxygenated Steroids from the Sponge Clathria gombawuiensis","volume":"80","author":"Woo","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.arr.2025.102935_bib319","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/mnfr.200900079","article-title":"Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice","volume":"53","author":"Woo","year":"2009","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.arr.2025.102935_bib320","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13137","article-title":"The neuronal receptor tyrosine kinase Alk is a target for longevity","volume":"19","author":"Woodling","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.arr.2025.102935_bib321","unstructured":"World Health Organization, 2021a. World failing to address dementia challenge. \u3008https:\/\/www.who.int\/news\/item\/02-09-2021-world-failing-to-address-dementia-challenge\u3009."},{"key":"10.1016\/j.arr.2025.102935_bib322","unstructured":"World Health Organization, 2021b. Global Health Estimates: Life expectancy and leading causes of death and disability. \u3008https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\u3009 (accessed 10 July 2023)."},{"key":"10.1016\/j.arr.2025.102935_bib323","unstructured":"World Health Organization, 2023. One Health definition and principles. \u3008https:\/\/www.who.int\/publications\/m\/item\/one-health-definitions-and-principles\u3009 (accessed 10 July 2023)."},{"key":"10.1016\/j.arr.2025.102935_bib324","unstructured":"World Health Organization, 2024. Chronic obstructive pulmonary disease (COPD). \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chronic-obstructive-pulmonary-disease-(copd)\u3009 (accessed 10 July 2023)."},{"key":"10.1016\/j.arr.2025.102935_bib325","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36411-2","article-title":"Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells","volume":"8","author":"Wu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib326","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1039\/D0FO03329D","article-title":"Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice","volume":"12","author":"Wu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2025.102935_bib327","article-title":"Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med 14 41534159"},{"key":"10.1016\/j.arr.2025.102935_bib328","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1065145","article-title":"Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16\/DAF-2\/SOD-3\/OLD-1\/PEPT-1 in Caenorhabditis elegans","volume":"9","author":"Wu","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib329","doi-asserted-by":"crossref","DOI":"10.3390\/md18060314","article-title":"Exploring the mechanism of flaccidoxide-13-Acetate in suppressing cell metastasis of hepatocellular carcinoma","volume":"18","author":"Wu","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib330","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.arr.2025.102935_bib331","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112676","article-title":"Recent advances and limitations in the application of kahalalides for the control of cancer","volume":"148","author":"Wyer","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2025.102935_bib332","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-015-0017-y","article-title":"Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice","volume":"5","author":"Xia","year":"2015","journal-title":"Cell Biosci."},{"key":"10.1016\/j.arr.2025.102935_bib333","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biocel.2014.08.009","article-title":"The Notch \u03b3-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-\u03b2\/Smad2\/3 signaling pathway activation","volume":"55","author":"Xiao","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.arr.2025.102935_bib334","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.825","article-title":"Effects of phycocyanin in modulating the intestinal microbiota of mice","volume":"8","author":"Xie","year":"2019","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.arr.2025.102935_bib335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-016-0464-3","article-title":"Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis","volume":"8","author":"Xue","year":"2017","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.arr.2025.102935_bib336","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-547","article-title":"Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line","volume":"14","author":"Yamauchi","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.arr.2025.102935_bib337","doi-asserted-by":"crossref","DOI":"10.3390\/md19090485","article-title":"Saringosterol from Sargassum fusiforme modulates cholesterol metabolism and alleviates atherosclerosis in ApoE-deficient mice","volume":"19","author":"Yan","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib338","doi-asserted-by":"crossref","DOI":"10.3390\/md21030144","article-title":"Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates","volume":"21","author":"Yang","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib339","article-title":"Ca2+-Dependent Glucose Transport in Skeletal Muscle by Diphlorethohydroxycarmalol, an Alga Phlorotannin: In Vitro and in Vivo Study","volume":"2021","author":"Yang","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2025.102935_bib340","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1021\/acsptsci.3c00136","article-title":"Marine Compound Exerts Antiaging Effect in Human Endothelial Progenitor Cells via Increasing Sirtuin1 Expression","volume":"6","author":"Yang","year":"2023","journal-title":"ACS Pharm. Transl. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib341","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bmc.2014.11.031","article-title":"Bioactive constituents from the green alga Caulerpa racemosa","volume":"23","author":"Yang","year":"2015","journal-title":"Bioorg. Med Chem."},{"key":"10.1016\/j.arr.2025.102935_bib342","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.jafc.3c08811","article-title":"Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice","volume":"72","author":"Yang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.arr.2025.102935_bib343","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1080\/14786419.2018.1528593","article-title":"Anti-inflammatory effect of fucoxanthin on dextran sulfate sodium-induced colitis in mice","volume":"34","author":"Yang","year":"2020","journal-title":"Nat. Prod. Res"},{"key":"10.1016\/j.arr.2025.102935_bib344","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/596240","article-title":"Supplemental cellular protection by a carotenoid extends lifespan via Ins\/IGF-1 signaling in Caenorhabditis elegans","author":"Yazaki","year":"2011","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2025.102935_bib345","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0959-440X(96)80073-X","article-title":"Structure of gap junction intercellular channels","volume":"6","author":"Yeager","year":"1996","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.arr.2025.102935_bib346","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21218241","article-title":"New insights into the role of histone changes in aging","volume":"21","author":"Yi","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2025.102935_bib347","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3748\/wjg.v23.i13.2330","article-title":"Notch signaling mediated by TGF-\u03b2\/Smad pathway in concanavalin A-induced liver fibrosis in rats","volume":"23","author":"Yi","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.arr.2025.102935_bib348","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jnutbio.2016.01.011","article-title":"Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoEshl mice deficient in apolipoprotein E expression","volume":"32","author":"Yokota","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.arr.2025.102935_bib349","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041079","article-title":"Effects of fucoxanthin on the inhibition of dexamethasone-induced skeletal muscle loss in mice","volume":"13","author":"Yoshikawa","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102935_bib350","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700136","article-title":"Fucoidan ameliorates pancreatic \u03b2-cell death and impaired insulin synthesis in streptozotocin-treated \u03b2 cells and mice via a Sirt-1-dependent manner","volume":"61","author":"Yu","year":"2017","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.arr.2025.102935_bib351","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu12103068","article-title":"Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2\/ho-1: An in vitro and in vivo study","volume":"12","author":"Yu","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.arr.2025.102935_bib352","doi-asserted-by":"crossref","DOI":"10.3390\/md14080149","article-title":"The algal meroterpene 11-hydroxy-1\u2032-O-methylamentadione ameloriates dextran sulfate sodium-induced colitis in mice","volume":"14","author":"Zbakh","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib353","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4103\/1673-5374.152387","article-title":"Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson\u2019s disease model in C57BL\/6J mice","volume":"10","author":"Zhang","year":"2015","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.arr.2025.102935_bib354","article-title":"Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K\/AKT\/mTOR Signaling Pathway","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2025.102935_bib355","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1021\/acs.jafc.4c02283","article-title":"Cluster of Differentiation 36 (CD36) Preferentially Mediates Intestinal Absorption of Dietary Z-Astaxanthin and Especially 9-Z-Isomer via Higher Binding Affinity","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.arr.2025.102935_bib356","article-title":"Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2025.102935_bib357","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/geroni\/igac059.2666","article-title":"Fucoidans are novel senotherapeutics that enhance Sirt6 and DNA repair activity","volume":"6","author":"Zhang","year":"2022","journal-title":"Innov. Aging"},{"key":"10.1016\/j.arr.2025.102935_bib358","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jff.2018.07.048","article-title":"Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1\/PI3K\/Akt and AMPK pathways","volume":"48","author":"Zhang","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.arr.2025.102935_bib359","article-title":"Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2025.102935_bib360","article-title":"C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota\u2014metabolites axis in mice","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.arr.2025.102935_bib361","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.ijbiomac.2017.08.123","article-title":"Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells","volume":"106","author":"Zhang","year":"2018","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102935_bib362","article-title":"Metabolomic Analysis Reveals That the Mechanism of Astaxanthin Improves the Osteogenic Differentiation Potential in Bone Marrow Mesenchymal Stem Cells","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.arr.2025.102935_bib363","doi-asserted-by":"crossref","first-page":"927","DOI":"10.14336\/AD.2019.0820","article-title":"Sirtuins and their biological relevance in aging and age-related diseases","volume":"11","author":"Zhao","year":"2020","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2025.102935_bib364","doi-asserted-by":"crossref","first-page":"7191","DOI":"10.1021\/acsbiomaterials.4c00998","article-title":"Targeting Synovial Macrophages with Astaxanthin-Loaded Liposomes for Antioxidant Treatment of Osteoarthritis","volume":"10","author":"Zhao","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.arr.2025.102935_bib365","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3390\/md13042306","article-title":"Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein E deficient mice","volume":"13","author":"Zhao","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib366","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.phrs.2007.12.001","article-title":"Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis","volume":"57","author":"Zhao","year":"2008","journal-title":"Pharm. Res"},{"key":"10.1016\/j.arr.2025.102935_bib367","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphar.2023.100159","article-title":"Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter \u03b1\/\u03b2 to reduce bile acids reabsorption","volume":"5","author":"Zhao","year":"2023","journal-title":"Curr. Res Pharm. Drug Discov."},{"key":"10.1016\/j.arr.2025.102935_bib368","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12061307","article-title":"3-Bromo-4,5-dihydroxybenzaldehyde Protects Keratinocytes from Particulate Matter 2.5-Induced Damages","volume":"12","author":"Zhen","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2025.102935_bib369","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4062\/biomolther.2013.030","article-title":"Fucoxanthin protects cultured human keratinocytes against oxidative stress by blocking free radicals and inhibiting apoptosis","volume":"21","author":"Zheng","year":"2013","journal-title":"Biomol. Ther. (Seoul. )"},{"key":"10.1016\/j.arr.2025.102935_bib370","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ijbiomac.2018.02.072","article-title":"Low molecular weight fucoidan attenuates liver injury via SIRT1\/AMPK\/PGC1\u03b1 axis in db\/db mice","volume":"112","author":"Zheng","year":"2018","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.arr.2025.102935_bib371","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/ja.2016.71","article-title":"The unique chemistry and biology of the piericidins","volume":"69","author":"Zhou","year":"2016","journal-title":"J. Antibiot."},{"key":"10.1016\/j.arr.2025.102935_bib372","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.archger.2013.10.005","article-title":"Mussel oligopeptides protect human fibroblasts from hydrogen peroxide (H2O2)-induced premature senescence","volume":"58","author":"Zhou","year":"2014","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.arr.2025.102935_bib373","doi-asserted-by":"crossref","DOI":"10.3390\/md15110358","article-title":"Asperlin inhibits LPS-evoked foam cell formation and prevents atherosclerosis in ApoE\u2212\/\u2212 mice","volume":"15","author":"Zhou","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2025.102935_bib374","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1039\/C8FO00021B","article-title":"Stress resistance and lifespan extension of: Caenorhabditis elegans enhanced by peptides from mussel (Mytilus edulis) protein hydrolyzate","volume":"9","author":"Zhou","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2025.102935_bib375","first-page":"5775","article-title":"Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt\/\u03b2-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages","volume":"15","author":"Zhu","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.arr.2025.102935_bib376","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1139\/H10-075","article-title":"Treatment with marine collagen peptides modulates glucose and lipid metabolism in chinese patients with type 2 diabetes mellitus","volume":"35","author":"Zhu","year":"2010","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.arr.2025.102935_bib377","doi-asserted-by":"crossref","first-page":"50258","DOI":"10.18632\/oncotarget.10361","article-title":"Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells","volume":"7","author":"Zovko","year":"2016","journal-title":"Oncotarget"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163725002818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:09:20Z","timestamp":1773842960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163725002818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":377,"alternative-id":["S1568163725002818"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2025.102935","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of marine-derived compounds in geroscience","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2025.102935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102935"}}