{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:48:09Z","timestamp":1783975689689,"version":"3.55.0"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ2086"],"award-info":[{"award-number":["2024JJ2086"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374552"],"award-info":[{"award-number":["82374552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.arr.2026.103099","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:32:29Z","timestamp":1773189149000},"page":"103099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Oligodendrocyte dysfunction in alzheimer's disease: Integrating spatial epigenomics and metabolic circuitry in demyelination \u2013 A critical review"],"prefix":"10.1016","volume":"118","author":[{"given":"Lian","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-0942","authenticated-orcid":false,"given":"Weijun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2026.103099_bib1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(18)30490-3","article-title":"The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications","volume":"18","author":"Arranz","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib2","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1093\/jxb\/erae165","article-title":"Redox regulation of epigenetic and epitranscriptomic gene regulatory pathways in plants","volume":"75","author":"Auverlot","year":"2024","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.arr.2026.103099_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54779-w","article-title":"Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease","volume":"15","author":"Baligacs","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103099_bib4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.neurobiolaging.2009.08.007","article-title":"Alzheimer's disease as homeostatic responses to age-related myelin breakdown","volume":"32","author":"Bartzokis","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103099_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jalz.2007.01.019","article-title":"Human brain myelination and amyloid beta deposition in Alzheimer's disease","volume":"3","author":"Bartzokis","year":"2007","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.arr.2026.103099_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/glia.22432","article-title":"Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men","volume":"61","author":"Behrendt","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103099_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020453","article-title":"Oligodendrocyte Development and Plasticity","volume":"8","author":"Bergles","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.arr.2026.103099_bib8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41586-022-05439-w","article-title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","volume":"611","author":"Blanchard","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103099_bib9","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3233\/JAD-230543","article-title":"Cerebral Gray and White Matter Monogalactosyl Diglyceride Levels Rise with the Progression of Alzheimer's Disease","volume":"95","author":"Blusztajn","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103099_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s004010050508","article-title":"Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis","volume":"92","author":"Braak","year":"1996","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2026.103099_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1389100","article-title":"Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development","volume":"17","author":"Brocato","year":"2024","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051236","article-title":"Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease","volume":"10","author":"Burillo","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103099_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mad.2016.11.002","article-title":"Long-term exposition to a high fat diet favors the appearance of beta-amyloid depositions in the brain of C57BL\/6J mice. A potential model of sporadic Alzheimer's disease","volume":"162","author":"Busquets","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2026.103099_bib14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41593-025-01973-8","article-title":"Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain","volume":"28","author":"Cai","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib15","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1007\/s00415-017-8593-x","article-title":"Astrocyte and Alzheimer's disease","volume":"264","author":"Cai","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib16","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.arr.2026.103099_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2024.08.003","article-title":"Disease-associated oligodendroglia: a putative nexus in neurodegeneration","author":"Castelo-Branco","year":"2024","journal-title":"Trends Immunol."},{"key":"10.1016\/j.arr.2026.103099_bib18","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103099_bib19","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.neuron.2021.05.012","article-title":"Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer\u2019s disease","volume":"109","author":"Chen","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103099_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","author":"Chuang","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fncel.2013.00268","article-title":"The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases","volume":"7","author":"Clemente","year":"2013","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7","article-title":"Relationship of iron to oligondendrocytes and myelination","volume":"17","author":"Connor","year":"1996","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103099_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70318","article-title":"The Neurochemical Landscape of Oligodendrocyte Physiology: From Myelination to Metabolic and Synaptic Modulation","volume":"169","author":"Correale","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2026.103099_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mod.2005.10.005","article-title":"Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS","volume":"123","author":"Cunliffe","year":"2006","journal-title":"Mech. Dev."},{"key":"10.1016\/j.arr.2026.103099_bib25","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301762RR","article-title":"Histone deacetylase-3 regulates the expression of the amyloid precursor protein and its inhibition promotes neuroregenerative pathways in Alzheimer's disease models","volume":"38","author":"Davis","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2026.103099_bib26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/ene.70397","article-title":"Recent Advances in Interventions Targeting Remyelination and a Systematic Review of Remyelinating Effects of Approved Disease-Modifying Treatments for Multiple Sclerosis","volume":"32","author":"De Keersmaecker","year":"2025","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The Cellular Phase of Alzheimer\u2019s Disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103099_bib29","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2016.3232","article-title":"Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease","volume":"74","author":"Dean","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-beta deposition in models of Alzheimer's disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103099_bib31","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2353\/ajpath.2010.100087","article-title":"Early oligodendrocyte\/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target","volume":"177","author":"Desai","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.arr.2026.103099_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071785","article-title":"TNFR2 Signaling Regulates the Immunomodulatory Function of Oligodendrocyte Precursor Cells","volume":"10","author":"Desu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103099_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipido"},{"key":"10.1016\/j.arr.2026.103099_bib34","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1007\/s12035-024-04617-3","article-title":"Integration of Single-Cell and Spatial Transcriptomic Data Reveals Spatial Architecture and Potential Biomarkers in Alzheimer's Disease","volume":"62","author":"Fan","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103099_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s40478-023-01607-9","article-title":"The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration","volume":"11","author":"Fodder","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2026.103099_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00702-017-1729-4","article-title":"Innate immunity in Alzheimer's disease: the relevance of animal models?","volume":"125","author":"Franco Bocanegra","year":"2018","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.arr.2026.103099_bib37","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/glia.22632","article-title":"Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate","volume":"62","author":"From","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103099_bib38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity","volume":"485","author":"F\u00fcnfschilling","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103099_bib39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/jnr.25151","article-title":"Emerging mitochondrial-mediated mechanisms involved in oligodendrocyte development","volume":"101","author":"Gil","year":"2023","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.arr.2026.103099_bib40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81553-6","article-title":"CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp\/Claudin-11 Null Mice","volume":"99","author":"Gow","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103099_bib41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S1474-4422(20)30440-3","article-title":"New insights into atypical Alzheimer's disease in the era of biomarkers","volume":"20","author":"Graff-Radford","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1006\/mcne.1996.0033","article-title":"Overexpression of 2\u2032,3\u2032-Cyclic Nucleotide 3\u2032-Phosphodiesterase in Transgenic Mice Alters Oligodendrocyte Development and Produces Aberrant Myelination","volume":"7","author":"Gravel","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103099_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 Variants in Alzheimer's Disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2026.103099_bib45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41557-018-0031-x","article-title":"Cholesterol catalyses Abeta42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes","volume":"10","author":"Habchi","year":"2018","journal-title":"Nat. Chem."},{"key":"10.1016\/j.arr.2026.103099_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/ejn.16242","article-title":"Single-cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases","volume":"59","author":"He","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311374","article-title":"Exploring the feasibility of using mice as a substitute model for investigating microglia in aging and Alzheimer's disease though single cell analysis","volume":"19","author":"He","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.arr.2026.103099_bib48","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bcp.2013.11.021","article-title":"TREM2 and the neuroimmunology of Alzheimer's disease","volume":"88","author":"Hickman","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2026.103099_bib50","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s40478-024-01893-x","article-title":"ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice","volume":"12","author":"Horiuchi","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.arr.2026.103099_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-025-02734-5","article-title":"Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state","author":"Hu","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.arr.2026.103099_bib52","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.arr.2026.103099_bib53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fncel.2020.00239","article-title":"The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay","volume":"14","author":"Jahn","year":"2020","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib54","doi-asserted-by":"crossref","first-page":"fcab125","DOI":"10.1093\/braincomms\/fcab125","article-title":"The role of the medial prefrontal cortex in cognition, ageing and dementia","volume":"3","author":"Jobson","year":"2021","journal-title":"Brain Commun."},{"key":"10.1016\/j.arr.2026.103099_bib55","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.3390\/cimb45120596","article-title":"The Roles of Caloric Restriction Mimetics in Central Nervous System Demyelination and Remyelination","volume":"45","author":"Kaffe","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.arr.2026.103099_bib56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.immuni.2024.11.024","article-title":"Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding beta-amyloidosis","volume":"58","author":"Kaji","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103099_bib57","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/2211-5463.13661","article-title":"Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities","volume":"14","author":"Kawade","year":"2024","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.arr.2026.103099_bib58","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41593-025-01873-x","article-title":"Oligodendrocytes in Alzheimer's disease pathophysiology","volume":"28","author":"Kedia","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.diabres.2019.07.004","article-title":"Oral diabetes medication and risk of dementia in elderly patients with type 2 diabetes","volume":"154","author":"Kim","year":"2019","journal-title":"Diabetes Res Clin. Pr."},{"key":"10.1016\/j.arr.2026.103099_bib60","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib61","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neubiorev.2020.02.012","article-title":"Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's disease-related pathology","volume":"112","author":"Kosel","year":"2020","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.arr.2026.103099_bib62","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103099_bib63","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib64","article-title":"An Epigenetic Role of Mitochondria in Cancer","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103099_bib65","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.cell.2024.04.005","article-title":"Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103099_bib66","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib67","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1093\/nar\/gku334","article-title":"Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA","volume":"42","author":"Madugundu","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arr.2026.103099_bib68","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuropharm.2016.09.009","article-title":"Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules","volume":"111","author":"Magalon","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2026.103099_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/srep42270","article-title":"Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease","volume":"7","author":"Mariani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103099_bib70","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00401-013-1137-2","article-title":"Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease","volume":"126","author":"McCarter","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2026.103099_bib71","doi-asserted-by":"crossref","first-page":"972","DOI":"10.2337\/dc18-1399","article-title":"Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer's Disease","volume":"42","author":"McIntosh","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arr.2026.103099_bib72","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13024-017-0219-3","article-title":"Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease","volume":"12","author":"McKenzie","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2026.103099_bib73","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuron.2021.12.034","article-title":"Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility","volume":"110","author":"Meijer","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103099_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11060359","article-title":"Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?","volume":"11","author":"Meyer","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.arr.2026.103099_bib75","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1038\/s41467-023-39046-8","article-title":"Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration","volume":"14","author":"Molina-Gonzalez","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103099_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/srep42041","article-title":"NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival","volume":"7","author":"Nakano","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103099_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2023.102782","article-title":"Expanding the function of oligodendrocytes to brain energy metabolism","volume":"83","author":"Nave","year":"2023","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.arr.2026.103099_bib78","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103099_bib79","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2019.08.015","article-title":"Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells","volume":"25","author":"Neumann","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2026.103099_bib80","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s13311-023-01402-3","article-title":"A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS","volume":"20","author":"Newsome","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.arr.2026.103099_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2021.100901","article-title":"Role of thyroid hormones in normal and abnormal central nervous system myelination in humans and rodents","volume":"61","author":"Pagnin","year":"2021","journal-title":"Front Neuroendocr."},{"key":"10.1016\/j.arr.2026.103099_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111189","article-title":"Disease-associated oligodendrocyte responses across neurodegenerative diseases","volume":"40","author":"Pandey","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2026.103099_bib83","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s12272-024-01519-9","article-title":"Exploring NNMT: from metabolic pathways to therapeutic targets","volume":"47","author":"Park","year":"2024","journal-title":"Arch. Pharm. Res"},{"key":"10.1016\/j.arr.2026.103099_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166986","article-title":"Cdk5-mediated oligodendrocyte myelin breakdown and neuroinflammation: Implications for the link between Type 2 Diabetes and Alzheimer's disease","volume":"1870","author":"Paul","year":"2024","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.arr.2026.103099_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2026.103099_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002727","article-title":"Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease","volume":"22","author":"Rajani","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2026.103099_bib87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molonc.2007.01.001","article-title":"The role of histone deacetylases (HDACs) in human cancer","volume":"1","author":"Ropero","year":"2007","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.arr.2026.103099_bib88","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13195-022-01074-9","article-title":"Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer's disease","volume":"14","author":"Rubinski","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.arr.2026.103099_bib89","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00018-022-04428-6","article-title":"Human myelin proteolipid protein structure and lipid bilayer stacking","volume":"79","author":"Ruskamo","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.arr.2026.103099_bib90","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.neuron.2022.03.008","article-title":"Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease","volume":"110","author":"Sadick","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103099_bib91","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/alz.12310","article-title":"Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression","volume":"17","author":"Saito","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.arr.2026.103099_bib92","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12035-023-03546-x","article-title":"Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination","volume":"61","author":"Sajad","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103099_bib93","first-page":"324","article-title":"Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma","volume":"20","author":"Sanaei","year":"2021","journal-title":"Iran. J. Pharm. Res"},{"key":"10.1016\/j.arr.2026.103099_bib94","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1172\/JCI90606","article-title":"Microglia in Alzheimer's disease","volume":"127","author":"Sarlus","year":"2017","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.arr.2026.103099_bib95","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/s41593-024-01730-3","article-title":"Oligodendrocytes produce amyloid-beta and contribute to plaque formation alongside neurons in Alzheimer's disease model mice","volume":"27","author":"Sasmita","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib96","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00125-025-06405-7","article-title":"Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-epsilon4","volume":"68","author":"Schain","year":"2025","journal-title":"Diabetologia"},{"key":"10.1016\/j.arr.2026.103099_bib97","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2026.103099_bib98","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mito.2009.12.141","article-title":"Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation","volume":"10","author":"Schoenfeld","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.arr.2026.103099_bib99","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"Shi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.arr.2026.103099_bib101","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1073\/pnas.95.11.6460","article-title":"Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons","volume":"95","author":"Simons","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103099_bib102","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020479","article-title":"Oligodendrocytes: Myelination and Axonal Support","volume":"8","author":"Simons","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.arr.2026.103099_bib103","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.arr.2026.103099_bib104","doi-asserted-by":"crossref","first-page":"17992","DOI":"10.1073\/pnas.0909607106","article-title":"Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate","volume":"106","author":"Skihar","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103099_bib105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2013.11.044","article-title":"Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue","volume":"156","author":"Snaidero","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103099_bib106","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.celrep.2016.12.053","article-title":"Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin","volume":"18","author":"Snaidero","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.arr.2026.103099_bib107","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/glia.24533","article-title":"Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons","volume":"72","author":"Spate","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103099_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002798","article-title":"Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease","volume":"22","author":"Spieth","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.arr.2026.103099_bib109","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00031.2018","article-title":"Myelin in the Central Nervous System: Structure, Function, and Pathology","volume":"99","author":"Stadelmann","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103099_bib110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50781-1","article-title":"Imbalance in the response of pre- and post-synaptic components to amyloidopathy","volume":"9","author":"Stephen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103099_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107921","article-title":"An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation","volume":"26","author":"Suhail","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.arr.2026.103099_bib112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41419-024-06476-1","article-title":"SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling","volume":"15","author":"Sun","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.arr.2026.103099_bib113","doi-asserted-by":"crossref","DOI":"10.1080\/17590914.2024.2401753","article-title":"Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development and Myelination","volume":"16","author":"Sutley-Koury","year":"2024","journal-title":"ASN Neuro"},{"key":"10.1016\/j.arr.2026.103099_bib114","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular dysfunction\u2014The disregarded partner of Alzheimer's disease","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.arr.2026.103099_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2025.105929","article-title":"Understanding the intricacies of cellular mechanisms in remyelination: The role of circadian rhythm","volume":"183","author":"Tang","year":"2025","journal-title":"Neurochem. Int"},{"key":"10.1016\/j.arr.2026.103099_bib116","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1046\/j.1471-4159.1996.67031014.x","article-title":"Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress","volume":"67","author":"Thorburne","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2026.103099_bib117","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41593-024-01613-7","article-title":"Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis","volume":"27","author":"Thornton","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103099_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103099_bib119","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stem.2018.12.013","article-title":"Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer's Disease Neurons","volume":"24","author":"van der Kant","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arr.2026.103099_bib120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer's Disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.arr.2026.103099_bib121","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jnc.12715","article-title":"Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects","volume":"130","author":"Vassar","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.arr.2026.103099_bib122","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1206998","article-title":"Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials","volume":"333","author":"Wake","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103099_bib123","article-title":"pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of C9orf72 ALS\/FTD patients","volume":"122","author":"Wang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103099_bib124","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-021-02407-1","article-title":"Cell type-specific potential pathogenic genes and functional pathways in Alzheimer\u2019s Disease","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Neurol."},{"key":"10.1016\/j.arr.2026.103099_bib125","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.4103\/NRR.NRR-D-24-00055","article-title":"Heterogeneity of mature oligodendrocytes in the central nervous system","volume":"20","author":"Weng","year":"2025","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.arr.2026.103099_bib126","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/cns.12809","article-title":"LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice","volume":"24","author":"Wu","year":"2018","journal-title":"CNS Neurosci. & Ther."},{"key":"10.1016\/j.arr.2026.103099_bib127","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4103\/1673-5374.355747","article-title":"The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease","volume":"18","author":"Wu","year":"2023","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.arr.2026.103099_bib128","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2337\/dc22-1705","article-title":"Association of Sodium-Glucose Cotransporter 2 Inhibitors With Time to Dementia: A Population-Based Cohort Study","volume":"46","author":"Wu","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arr.2026.103099_bib129","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bbrc.2017.06.099","article-title":"Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation","volume":"490","author":"Xu","year":"2017","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.arr.2026.103099_bib130","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S1740925X08000070","article-title":"Modulatory effects of oligodendrocytes on the conduction velocity of action potentials along axons in the alveus of the rat hippocampal CA1 region","volume":"3","author":"Yamazaki","year":"2007","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.arr.2026.103099_bib131","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1080\/15548627.2020.1871204","article-title":"BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes","volume":"17","author":"Yazdankhah","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103099_bib132","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2015.11.018","article-title":"Ketones block amyloid entry and improve cognition in an Alzheimer's model","volume":"39","author":"Yin","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103099_bib133","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.arr.2026.103099_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb8680","article-title":"Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer\u2019s disease","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2026.103099_bib135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neurobiolaging.2016.03.004","article-title":"Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation","volume":"42","author":"Zheng","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103099_bib136","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/cns.12154","article-title":"Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair","volume":"19","author":"Zhornitsky","year":"2013","journal-title":"CNS Neurosci. Ther."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726000917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726000917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:17:58Z","timestamp":1778822278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726000917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":136,"alternative-id":["S1568163726000917"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103099","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oligodendrocyte dysfunction in alzheimer's disease: Integrating spatial epigenomics and metabolic circuitry in demyelination \u2013 A critical review","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103099"}}