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Sci."},{"key":"10.1016\/j.arr.2026.103257_bib80","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1021\/acs.jmedchem.8b00733","article-title":"Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization","volume":"61","author":"Fulp","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.arr.2026.103257_bib81","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41419-026-08424-7","article-title":"Mitochondrial DNA drives NLRP3-IL-1\u03b2 axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models","volume":"17","author":"Gan","year":"2026","journal-title":"Cell. 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Rev."},{"key":"10.1016\/j.arr.2026.103257_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101579","article-title":"Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations","volume":"76","author":"Gupta","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103257_bib96","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-b","volume":"9","author":"Halle","year":"2008","journal-title":"eta. Nat. 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