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Sci."},{"key":"10.1016\/j.arr.2026.103272_bib65","first-page":"1411","article-title":"The regulation of stem cell aging by Wnt signaling","volume":"30","author":"Fujimaki","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.arr.2026.103272_bib66","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s42255-022-00533-9","article-title":"The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass","volume":"4","author":"Fujimaki","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.arr.2026.103272_bib67","doi-asserted-by":"crossref","DOI":"10.1007\/s11517-025-03403-0","article-title":"Model-based analysis of sEMG signals using Stockwell transform features under varied muscle fiber composition and conduction velocity","author":"G","year":"2025","journal-title":"Med. Biol. Eng. 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Metab."},{"key":"10.1016\/j.arr.2026.103272_bib107","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103272_bib108","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148372","article-title":"Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction","volume":"131","author":"Lee","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103272_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110785","article-title":"Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations","volume":"39","author":"Leinroth","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib110","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nm.3869","article-title":"Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro\/adipogenic progenitors","volume":"21","author":"Lemos","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103272_bib111","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.067595","article-title":"An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration","volume":"138","author":"Lepper","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.arr.2026.103272_bib112","article-title":"Downregulation of TGF-\u03b21 in fibro-adipogenic progenitors initiates muscle ectopic mineralization","author":"Li","year":"2024","journal-title":"J. Bone Miner. Res. 39 1147-1161"},{"key":"10.1016\/j.arr.2026.103272_bib113","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41419-024-06863-8","article-title":"mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells","volume":"15","author":"Li","year":"2024","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103272_bib114","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1038\/s41467-025-61403-y","article-title":"Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia","volume":"16","author":"Li","year":"2025","journal-title":"Nat. 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Res."},{"key":"10.1016\/j.arr.2026.103272_bib122","article-title":"Differential transcriptomic profiling of lipid metabolism and collagen remodeling in fast- and slow-twitch skeletal muscles in aging","volume":"39","author":"Liu","year":"2025","journal-title":"Faseb J."},{"key":"10.1016\/j.arr.2026.103272_bib123","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1523\/JNEUROSCI.0410-10.2010","article-title":"Distinct presynaptic and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis","volume":"30","author":"Liu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103272_bib124","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2018.12.014","article-title":"Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors","volume":"24","author":"Lukjanenko","year":"2019","journal-title":"Cell. 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Biol."},{"key":"10.1016\/j.arr.2026.103272_bib128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2022.03.002","article-title":"Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish","volume":"109","author":"Malbouyres","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.arr.2026.103272_bib129","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1038\/s41467-018-06068-6","article-title":"Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy","volume":"9","author":"Malecova","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103272_bib130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mcn.2005.07.002","article-title":"Analysis of mRNAs that are enriched in the post-synaptic domain of the neuromuscular junction","volume":"30","author":"McGeachie","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103272_bib131","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101298R","article-title":"The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway","volume":"36","author":"McKee","year":"2022","journal-title":"Faseb J."},{"key":"10.1016\/j.arr.2026.103272_bib132","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.18632\/aging.103418","article-title":"Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin","volume":"12","author":"Mehdipour","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.arr.2026.103272_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103189","article-title":"Time-restricted feeding improves aortic endothelial relaxation by enhancing mitochondrial function and attenuating oxidative stress in aged mice","volume":"73","author":"Milan","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2026.103272_bib134","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1152\/physiolgenomics.00115.2020","article-title":"eQTL variants in COL22A1 are associated with muscle injury in athletes","volume":"52","author":"Miyamoto-Mikami","year":"2020","journal-title":"Physiol. 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Biol."},{"key":"10.1016\/j.arr.2026.103272_bib140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.15252\/embr.201439757","article-title":"Single muscle fiber proteomics reveals unexpected mitochondrial specialization","volume":"16","author":"Murgia","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2026.103272_bib141","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.celrep.2017.05.054","article-title":"Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging","volume":"19","author":"Murgia","year":"2017","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib142","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2012.03.047","article-title":"Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes","volume":"149","author":"Naito","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103272_bib143","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.1038\/s41467-022-34191-y","article-title":"Depletion of CD206(+) M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration","volume":"13","author":"Nawaz","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103272_bib144","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1152\/physiolgenomics.00227.2004","article-title":"Intracellular expression profiling by laser capture microdissection: three novel components of the neuromuscular junction","volume":"21","author":"Nazarian","year":"2005","journal-title":"Physiol. 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Rev."},{"key":"10.1016\/j.arr.2026.103272_bib151","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2026.103272_bib152","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1002\/jcsm.13091","article-title":"Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia","volume":"13","author":"Peng","year":"2022","journal-title":"J. Cachex-.-. 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Rep."},{"key":"10.1016\/j.arr.2026.103272_bib156","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/nm.3655","article-title":"Inhibition of JAK-STAT signaling stimulates adult satellite cell function","volume":"20","author":"Price","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103272_bib157","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/j.gendis.2023.01.005","article-title":"Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing","volume":"10","author":"Qiu","year":"2023","journal-title":"Genes. Dis."},{"key":"10.1016\/j.arr.2026.103272_bib158","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41418-020-0551-y","article-title":"Adipogenesis of skeletal muscle fibro\/adipogenic progenitors is affected by the WNT5a\/GSK3\/\u03b2-catenin axis","volume":"27","author":"Reggio","year":"2020","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.arr.2026.103272_bib159","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1152\/physrev.00039.2022","article-title":"Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions","volume":"103","author":"Roberts","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103272_bib160","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nature13255","article-title":"mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)","volume":"510","author":"Rodgers","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103272_bib161","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.celrep.2017.03.066","article-title":"HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G(Alert)","volume":"19","author":"Rodgers","year":"2017","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib162","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41598-019-57110-6","article-title":"Single-cell transcriptional profiles in human skeletal muscle","volume":"10","author":"Rubenstein","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115850","article-title":"Non-canonical Ca(2+)- Akt signaling pathway mediates the antiproteolytic effects induced by oxytocin receptor stimulation in skeletal muscle","volume":"217","author":"Santos","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.arr.2026.103272_bib164","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-4939-9650-6_8","article-title":"Multiparametric Flow Cytometry Analysis of Na\u00efve, Memory, and Effector T Cells","volume":"2032","author":"Saxena","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.arr.2026.103272_bib165","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"Schiaffino","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103272_bib166","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/febs.13827","article-title":"Regulatory T cells and skeletal muscle regeneration","volume":"284","author":"Schiaffino","year":"2017","journal-title":"Febs J."},{"key":"10.1016\/j.arr.2026.103272_bib167","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2019.11.004","article-title":"Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration","volume":"25","author":"Scott","year":"2019","journal-title":"Cell. 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Rep."},{"issue":"7727","key":"10.1016\/j.arr.2026.103272_bib185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","volume":"562","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103272_bib186","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.biochi.2019.07.014","article-title":"Skeletal muscle atrogenes: From rodent models to human pathologies","volume":"166","author":"Taillandier","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.arr.2026.103272_bib187","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bbrc.2014.03.084","article-title":"The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle","volume":"446","author":"Tajrishi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103272_bib188","doi-asserted-by":"crossref","DOI":"10.2174\/0115665240327723241018073535","article-title":"The Hormetic Potential of GDF15 in Skeletal Muscle Health and Regeneration: A Comprehensive Systematic Review","author":"Tarchi","year":"2025","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.arr.2026.103272_bib189","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nri.2016.150","article-title":"Regulation of muscle growth and regeneration by the immune system","volume":"17","author":"Tidball","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103272_bib190","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.celrep.2016.01.072","article-title":"Autonomous Extracellular Matrix Remodeling Controls a Progressive Adaptation in Muscle Stem Cell Regenerative Capacity during Development","volume":"14","author":"Tierney","year":"2016","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib191","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/physrev.00033.2014","article-title":"Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting","volume":"95","author":"Tintignac","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103272_bib192","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205002","article-title":"TGF-\u03b2 Signaling in Cellular Senescence and Aging-Related Pathology","volume":"20","author":"Tominaga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103272_bib193","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. 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Physiol."},{"key":"10.1016\/j.arr.2026.103272_bib196","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72730-z","article-title":"DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity","volume":"10","author":"Turner","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103272_bib197","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139617","article-title":"Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia","volume":"131","author":"Uezumi","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103272_bib198","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1038\/ncomms2964","article-title":"Collagen VI regulates satellite cell self-renewal and muscle regeneration","volume":"4","author":"Urciuolo","year":"2013","journal-title":"Nat. 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