{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:52Z","timestamp":1792790392323,"version":"4.5.0"},"reference-count":284,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.arr.2026.103273","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:32:29Z","timestamp":1785072749000},"page":"103273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Targeting the NLRP3 inflammasome in Alzheimer\u2019s disease: Mechanistic insights and therapeutic advances"],"prefix":"10.1016","volume":"121","author":[{"given":"Wenwen","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiekun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiku","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2026.103273_bib1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3233\/JAD-170634","article-title":"Co-Localization of Glia Maturation Factor with NLRP3 inflammasome and autophagosome markers in human Alzheimer's disease brain","volume":"60","author":"Ahmed","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103273_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.intimp.2017.10.024","article-title":"TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease","volume":"54","author":"Aminzadeh","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib3","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1016\/j.cell.2021.11.011","article-title":"NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation","volume":"184","author":"Andreeva","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103273_bib4","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3389\/fimmu.2019.01511","article-title":"Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1\/Nrf2 pathway","volume":"10","author":"Arioz","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.intimp.2017.08.007","article-title":"Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model","volume":"51","author":"Aryanpour","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-019-1669-z","article-title":"Interleukin-1\u03b2 drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site","volume":"16","author":"Balasubramaniam","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib7","article-title":"Resveratrol activates antioxidant protective mechanisms in cellular models of Alzheimer's disease inflammation","volume":"13","author":"Bartra","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.arr.2026.103273_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12974-021-02099-x","article-title":"Interleukin-1\u03b2 mediates alterations in mitochondrial fusion\/fission proteins and memory impairment induced by amyloid-\u03b2 oligomers","volume":"18","author":"Batista","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease","volume":"28","author":"Baum","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/npp.2013.208","article-title":"Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model","volume":"39","author":"Ben-Menachem-Zidon","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.arr.2026.103273_bib11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1006\/nbdi.2000.0321","article-title":"Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes","volume":"7","author":"Blasko","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2026.103273_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)12192-7","article-title":"Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients","volume":"202","author":"Blum-Degen","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2026.103273_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fendo.2011.00050","article-title":"Neuroprotective actions of neurosteroids","volume":"2","author":"Borowicz","year":"2011","journal-title":"Front. Endocrinol. (Lausanne"},{"key":"10.1016\/j.arr.2026.103273_bib14","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cmdc.200900531","article-title":"A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety","volume":"5","author":"Boxer","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.arr.2026.103273_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","article-title":"Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing","volume":"8","author":"Broz","year":"2010","journal-title":"Cell. Host Microbe"},{"key":"10.1016\/j.arr.2026.103273_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib17","article-title":"Salidroside ameliorates Alzheimer's disease by targeting nlrp3 inflammasome-mediated pyroptosis","volume":"13","author":"Cai","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1080\/15548627.2021.1965426","article-title":"USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3","volume":"18","author":"Cai","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103273_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102139","article-title":"P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy","volume":"206","author":"Carvalho","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2026.103273_bib20","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1073\/pnas.1421699112","article-title":"Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens","volume":"112","author":"Casson","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib21","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1073\/pnas.87.10.3861","article-title":"Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain","volume":"87","author":"Cataldo","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib22","doi-asserted-by":"crossref","first-page":"10998","DOI":"10.1073\/pnas.88.24.10998","article-title":"Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease","volume":"88","author":"Cataldo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuro.2018.11.001","article-title":"The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis","volume":"70","author":"Chan","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.arr.2026.103273_bib24","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/jcp.24903","article-title":"Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy","volume":"230","author":"Chang","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.arr.2026.103273_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cyto.2019.03.003","article-title":"IL-18 induced IL-23\/IL-17 expression impairs A\u03b2 clearance in cultured THP-1 and BV2 cells","volume":"119","author":"Chen","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.arr.2026.103273_bib27","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.neurobiolaging.2015.05.018","article-title":"NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure","volume":"36","author":"Chen","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103273_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnmol.2019.00014","article-title":"27-Hydroxycholesterol contributes to lysosomal membrane permeabilization-mediated pyroptosis in co-cultured SH-SY5Y cells and C6 cells","volume":"12","author":"Chen","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejphar.2015.11.048","article-title":"Epigallocatechin gallate attenuates amyloid \u03b2-induced inflammation and neurotoxicity in EOC 13.31 microglia","volume":"770","author":"Cheng-Chung Wei","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41422-020-0295-8","article-title":"Toward targeting inflammasomes: insights into their regulation and activation","volume":"30","author":"Christgen","year":"2020","journal-title":"Cell. Res."},{"key":"10.1016\/j.arr.2026.103273_bib31","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1189\/jlb.0309164","article-title":"Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner","volume":"86","author":"Chu","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103273_bib34","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1021\/bi400426t","article-title":"Tranilast binds to a\u03b2 monomers and promotes a\u03b2 fibrillation","volume":"52","author":"Connors","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.arr.2026.103273_bib35","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0269881114552744","article-title":"Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population","volume":"29","author":"Cox","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-2094-2-15","article-title":"Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid","volume":"2","author":"Craft","year":"2005","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib37","article-title":"Alzheimer's disease drug development pipeline: 2025","volume":"11","author":"Cummings","year":"2025","journal-title":"Alzheimers Dement. (N. Y"},{"key":"10.1016\/j.arr.2026.103273_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.phrs.2014.10.009","article-title":"Tranilast: a review of its therapeutic applications","volume":"91","author":"Darakhshan","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2026.103273_bib39","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-\u03b2 and cognitive function in APP\/PS1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2026.103273_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102173","article-title":"P2X7 receptor blockade reduces tau induced toxicity, therapeutic implications in tauopathies","volume":"208","author":"Di Lauro","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.arr.2026.103273_bib41","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1111\/j.1460-9568.2006.04780.x","article-title":"Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia","volume":"23","author":"Di Rosa","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib42","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.neurobiolaging.2011.09.040","article-title":"vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3\u03b2 and secretases","volume":"33","author":"Diaz-Hernandez","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103273_bib43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.redox.2016.08.006","article-title":"Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression","volume":"9","author":"Du","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2026.103273_bib44","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib45","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1073\/pnas.0611496104","article-title":"Cryopyrin\/NALP3 binds ATP\/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling","volume":"104","author":"Duncan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer's disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.arr.2026.103273_bib47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12974-018-1319-x","article-title":"\u03b11-antitrypsin mitigates NLRP3-inflammasome activation in amyloid \u03b2(1-42)-stimulated murine astrocytes","volume":"15","author":"Ebrahimi","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112359","article-title":"Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease","volume":"379","author":"Esmaeili","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib49","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2013.11.030","article-title":"Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemia","volume":"1545","author":"Espinosa-Garc\u00eda","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8099459","article-title":"Melatonin ameliorates the progression of Alzheimer's disease by inducing TFEB nuclear translocation, promoting mitophagy, and regulating NLRP3 inflammasome activity","volume":"2022","author":"Fan","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.arr.2026.103273_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroscience.2018.02.046","article-title":"chronic amyloid \u03b2 oligomer infusion evokes sustained inflammation and microglial changes in the rat hippocampus via NLRP3","volume":"405","author":"Fekete","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2026.103273_bib52","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/cns.12983","article-title":"Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP\/PS1 transgenic mice","volume":"24","author":"Feng","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib53","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1089\/dna.2018.4308","article-title":"Resveratrol suppresses A\u03b2-induced microglial activation through the TXNIP\/TRX\/NLRP3 signaling pathway","volume":"38","author":"Feng","year":"2019","journal-title":"DNA Cell. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11011-019-00512-2","article-title":"Increased inflammation in BA21 brain tissue from African Americans with Alzheimer's disease","volume":"35","author":"Ferguson","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2026.103273_bib55","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1038\/s41467-018-06449-x","article-title":"Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model","volume":"9","author":"Flores","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib56","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-020-18405-9","article-title":"Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging","volume":"11","author":"Flores","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib57","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4049\/jimmunol.0900173","article-title":"Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation","volume":"183","author":"Franchi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib58","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20150237","article-title":"NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes","volume":"214","author":"Freeman","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.arr.2026.103273_bib59","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","article-title":"Human monocytes engage an alternative inflammasome pathway","volume":"44","author":"Gaidt","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib60","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2017.09.039","article-title":"The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3","volume":"171","author":"Gaidt","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103273_bib61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coi.2016.10.007","article-title":"Alternative inflammasome activation enables IL-1\u03b2 release from living cells","volume":"44","author":"Gaidt","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111584","article-title":"Potentiating the benefits of melatonin through chemical functionalization: possible impact on multifactorial neurodegenerative disorders","volume":"22","author":"Galano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103273_bib63","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"GBD","year":"2022","journal-title":"Lancet Public. Health"},{"key":"10.1016\/j.arr.2026.103273_bib64","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1523\/JNEUROSCI.4361-12.2013","article-title":"Sustained interleukin-1\u03b2 overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model","volume":"33","author":"Ghosh","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsbmb.2005.01.016","article-title":"Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons","volume":"94","author":"Gonzalez","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib66","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","article-title":"K(+) efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria","volume":"45","author":"Gro\u00df","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10020-021-00273-8","article-title":"Caspase-1\/IL-1\u03b2 represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer's disease","volume":"27","author":"Gu","year":"2021","journal-title":"Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib68","article-title":"Eriodictyol and homoeriodictyol improve memory impairment in A\u03b2(25-35)-induced mice by inhibiting the NLRP3 inflammasome","volume":"27","author":"Guo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2026.103273_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2025.106158","article-title":"Galectin-9 activates the TLR4-NLRP3 inflammasome pathway and promotes tau pathology in Alzheimer's disease","volume":"131","author":"Guo","year":"2026","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.arr.2026.103273_bib70","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molmed.2014.11.008","article-title":"Mitochondria: diversity in the regulation of the NLRP3 inflammasome","volume":"21","author":"Gurung","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130624","article-title":"NLRP3 Inflammasome is expressed and functional in mouse brain microglia but not in astrocytes","volume":"10","author":"Gustin","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.arr.2026.103273_bib72","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-b","volume":"9","author":"Halle","year":"2008","journal-title":"eta. Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib73","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1182\/blood.V90.8.2911","article-title":"Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1","volume":"90","author":"Hamon","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.arr.2026.103273_bib74","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 pathway in Alzheimer's disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2026.103273_bib75","article-title":"Inhibiting NLRP3 inflammasome activation by CY-09 helps to restore cerebral glucose metabolism in 3\u00d7Tg-AD mice","volume":"12","author":"Han","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.arr.2026.103273_bib76","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12525","article-title":"Melatonin and inflammation-Story of a double-edged blade","volume":"65","author":"Hardeland","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.arr.2026.103273_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/370368","article-title":"Inhibitory effects of edaravone in \u03b2-amyloid-induced neurotoxicity in rats","volume":"2014","author":"He","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.arr.2026.103273_bib78","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib79","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib80","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.4049\/jimmunol.1301490","article-title":"Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation","volume":"191","author":"Heid","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib81","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib82","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/cmdc.201700270","article-title":"Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors","volume":"12","author":"Hill","year":"2017","journal-title":"ChemMedChem"},{"key":"10.1016\/j.arr.2026.103273_bib83","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41586-022-04467-w","article-title":"Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3","volume":"604","author":"Hochheiser","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102348","article-title":"Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit","volume":"99","author":"H\u00f8ilund-Carlsen","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103273_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.05.054","article-title":"The neuroprotection of progesterone against A\u03b2-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes","volume":"74","author":"Hong","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib86","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/JAD-131370","article-title":"Brain pyroglutamate amyloid-\u03b2 is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic","volume":"41","author":"Hook","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103273_bib87","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib88","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib89","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708689","article-title":"Tranilast directly targets NLRP3 to treat inflammasome-driven diseases","volume":"10","author":"Huang","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108305","article-title":"NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia","volume":"180","author":"Hull","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.arr.2026.103273_bib91","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105104","article-title":"ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease","volume":"148","author":"Ismael","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.arr.2026.103273_bib93","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031453","article-title":"Resveratrol supplementation attenuates cognitive and molecular alterations under maternal high-fat diet intake: epigenetic inheritance over generations","volume":"22","author":"Izquierdo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103273_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113890","article-title":"An in silico investigation on the interactions of curcumin and epigallocatechin-3-gallate with NLRP3 Inflammasome complex","volume":"156","author":"Jena","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2026.103273_bib96","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.taap.2016.08.029","article-title":"Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure","volume":"309","author":"Jessop","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib97","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jalz.2017.12.006","article-title":"The cost of Alzheimer's disease in China and re-estimation of costs worldwide","volume":"14","author":"Jia","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.arr.2026.103273_bib98","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1007\/s11033-022-07177-8","article-title":"Thioredoxin-1 inhibits amyloid-\u03b2(25-35)-induced activation of NLRP1\/caspase-1\/GSDMD pyroptotic pathway in PC12 cells","volume":"49","author":"Jia","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.arr.2026.103273_bib99","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.arr.2026.103273_bib100","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1073\/pnas.1422998112","article-title":"Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits","volume":"112","author":"Jiao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib101","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib102","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/glia.22891","article-title":"NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients","volume":"63","author":"Johann","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103273_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173416","article-title":"Glibenclamide modulates microglial function and attenuates A\u03b2 deposition in 5XFAD mice","volume":"884","author":"Ju","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib104","first-page":"C1100","article-title":"Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol","volume":"286","author":"Kahlenberg","year":"2004"},{"key":"10.1016\/j.arr.2026.103273_bib105","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.4049\/jimmunol.1402658","article-title":"K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling","volume":"194","author":"Katsnelson","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib106","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/cdd.2015.16","article-title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation","volume":"22","author":"Kaushal","year":"2015","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.arr.2026.103273_bib107","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib108","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103273_bib109","article-title":"Donepezil regulates LPS and A\u03b2-stimulated neuroinflammation through MAPK\/NLRP3 inflammasome\/STAT3 signaling","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103273_bib110","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","article-title":"Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer's disease model","volume":"187","author":"Kitazawa","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib111","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-019-1471-y","article-title":"A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury","volume":"16","author":"Kuwar","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib112","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3233\/JAD-210400","article-title":"A novel inhibitor targeting NLRP3 inflammasome reduces neuropathology and improves cognitive function in Alzheimer's disease transgenic mice","volume":"82","author":"Kuwar","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103273_bib113","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103273_bib114","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"Lamkanfi","year":"2009","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib115","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3945\/jn.109.109785","article-title":"Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice","volume":"139","author":"Lee","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.arr.2026.103273_bib116","article-title":"Idebenone regulates A\u03b2 and LPS-induced neurogliosis and cognitive function through inhibition of NLRP3 inflammasome\/IL-1\u03b2 axis activation","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib117","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3858\/emm.2011.43.1.001","article-title":"Microglial P2X\u2087 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"43","author":"Lee","year":"2011","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib118","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/cns.13384","article-title":"Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia","volume":"26","author":"Li","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib119","article-title":"The changes of NLRs family members in the brain of AD mouse model and AD patients","volume":"16","author":"Li","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JAD-180814","article-title":"Thioredoxin-interacting protein (TXNIP) associated NLRP3 inflammasome activation in human Alzheimer's disease brain","volume":"68","author":"Li","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103273_bib121","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1523\/JNEUROSCI.20-01-00149.2000","article-title":"Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression","volume":"20","author":"Li","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib122","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/ptr.8461","article-title":"Gastrodin ameliorates tau pathology and BBB dysfunction in 3xTg-AD transgenic mice by regulating the ADRA1\/NF-\u03baB\/NLRP3 pathway to reduce neuroinflammation","volume":"39","author":"Li","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.arr.2026.103273_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120615","article-title":"Cornuside ameliorates LPS induced cognitive dysfunction and microglial NLRP3 inflammasome activation by enhancing Sirt1-mediated autophagy","volume":"355","author":"Lian","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib124","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.4161\/cc.24903","article-title":"Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death","volume":"12","author":"Lima","year":"2013","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.arr.2026.103273_bib125","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.1320294111","article-title":"IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib126","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12974-023-02698-w","article-title":"TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB\/TFE3 activation","volume":"20","author":"Lin","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109691","article-title":"Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model","volume":"744","author":"Liu","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.arr.2026.103273_bib128","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s12035-013-8608-2","article-title":"-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA\/p75NTR signaling in APP\/PS1 transgenic mice","volume":"49","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103273_bib129","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2018.12.012","article-title":"Cell-type-specific interleukin 1 receptor 1 signaling in the brain regulates distinct neuroimmune activities","volume":"50","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib130","article-title":"Kai-Xin-San ameliorates mild cognitive impairment in SAMP8 mice by inhibiting neuroinflammation and pyroptosis via NLRP3\/Caspase-1 pathway modulation","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib131","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1038\/s41423-020-00567-7","article-title":"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy","volume":"18","author":"Liu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib132","first-page":"2800","article-title":"Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats","volume":"8","author":"Liu","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2026.103273_bib133","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.arr.2026.103273_bib134","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154801","article-title":"Myricetin improves pathological changes in 3\u00d7Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway","volume":"115","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arr.2026.103273_bib136","doi-asserted-by":"crossref","first-page":"32145","DOI":"10.1073\/pnas.2009680117","article-title":"The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease","volume":"117","author":"Lonnemann","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib137","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/alz.12341","article-title":"Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1\u03b2 drives amplified responses in primed astrocytes and neuronal network dysfunction","volume":"17","author":"Lopez-Rodriguez","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.arr.2026.103273_bib138","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nsmb.3199","article-title":"Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism","volume":"23","author":"Lu","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib139","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103273_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1018848","article-title":"Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease","volume":"14","author":"Lu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib141","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.apsb.2024.11.010","article-title":"Drofenine as a Kv2.1 inhibitor alleviated AD-like pathology in mice through A\u03b2\/Kv2.1\/microglial NLRP3\/neuronal Tau axis","volume":"15","author":"Lu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.arr.2026.103273_bib142","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031731","article-title":"The therapeutic prospects of targeting IL-1R1 for the modulation of neuroinflammation in central nervous system disorders","volume":"23","author":"Lu\u00eds","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103273_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101973","article-title":"Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus","volume":"43","author":"Madhu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2026.103273_bib144","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1716095115","article-title":"OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation","volume":"115","author":"Marchetti","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib145","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13075-018-1664-2","article-title":"NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis","volume":"20","author":"Marchetti","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib146","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib147","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41380-018-0108-3","article-title":"New role of P2X7 receptor in an Alzheimer's disease mouse model","volume":"24","author":"Martin","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2026.103273_bib148","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fncel.2019.00143","article-title":"Amyloid peptide induced neuroinflammation increases the P2X7 receptor expression in microglial cells, impacting on its functionality","volume":"13","author":"Mart\u00ednez-Frailes","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib149","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib151","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1097\/01.jnen.0000240470.97295.d3","article-title":"Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus","volume":"65","author":"McLarnon","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2026.103273_bib152","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.immuni.2025.01.007","article-title":"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression","volume":"58","author":"McManus","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib153","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1080\/15548627.2019.1628544","article-title":"IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1\/p62-dependent selective autophagy","volume":"15","author":"Mehto","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103273_bib154","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.coi.2020.10.011","article-title":"The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease","volume":"68","author":"Milner","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106300","article-title":"\u03b2-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease","volume":"81","author":"Mokarizadeh","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib156","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00401-022-02528-y","article-title":"Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons","volume":"145","author":"Moonen","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2026.103273_bib157","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41590-022-01192-4","article-title":"Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome","volume":"23","author":"Moretti","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib158","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1021\/acschemneuro.0c00516","article-title":"Ameliorative effect of necrosulfonamide in a rat model of Alzheimer's disease: targeting mixed lineage kinase domain-like protein-mediated necroptosis","volume":"11","author":"Motawi","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib159","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.imlet.2007.09.002","article-title":"Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression","volume":"114","author":"Motta","year":"2007","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.arr.2026.103273_bib160","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2006.07.027","article-title":"Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease","volume":"51","author":"Mueller-Steiner","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103273_bib161","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K\u207a efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib162","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib163","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3940(91)90395-A","article-title":"Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease","volume":"130","author":"Nakamura","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.arr.2026.103273_bib164","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages","volume":"113","author":"Netea","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.arr.2026.103273_bib165","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s12640-022-00535-1","article-title":"Curcumin-attenuated TREM-1\/DAP12\/NLRP3\/Caspase-1\/IL1B, TLR4\/NF-\u03baB pathways, and tau hyperphosphorylation induced by 1,2-diacetyl benzene: an in vitro and in silico study","volume":"40","author":"Nguyen","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.arr.2026.103273_bib166","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bbrc.2013.03.079","article-title":"Silencing of the P2X(7) receptor enhances amyloid-\u03b2 phagocytosis by microglia","volume":"434","author":"Ni","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib167","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45220-1","article-title":"The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines","volume":"13","author":"Nopparat","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103273_bib168","article-title":"The role of cathepsin b in the degradation of A\u03b2 and in the production of A\u03b2 peptides starting with Ala2 in cultured astrocytes","volume":"13","author":"Oberstein","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib169","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121353119","article-title":"Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation","volume":"119","author":"Ohto","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neurobiolaging.2007.06.006","article-title":"Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients","volume":"30","author":"Ojala","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103273_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071652","article-title":"Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells","volume":"10","author":"Panda","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103273_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114919","article-title":"Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis","volume":"245","author":"Pang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.arr.2026.103273_bib173","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/jpi.12260","article-title":"Melatonin regulates the transcription of \u03b2APP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells","volume":"59","author":"Panmanee","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.arr.2026.103273_bib174","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/mol.107.034868","article-title":"Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death","volume":"72","author":"Pannaccione","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib175","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.503","article-title":"Oligomeric amyloid \u03b2 induces IL-1\u03b2 processing via production of ROS: implication in Alzheimer's disease","volume":"4","author":"Parajuli","year":"2013","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103273_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100966","article-title":"Is Alzheimer's disease an inflammasomopathy?","volume":"56","author":"Pereira","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103273_bib177","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00401-018-1903-2","article-title":"Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease","volume":"136","author":"Pickett","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2026.103273_bib178","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/glia.23970","article-title":"\u03b1-Synuclein evokes NLRP3 inflammasome-mediated IL-1\u03b2 secretion from primary human microglia","volume":"69","author":"Pike","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103273_bib179","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.neurobiolaging.2005.09.038","article-title":"Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K+ current","volume":"27","author":"Plant","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.arr.2026.103273_bib180","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archneur.60.3.369","article-title":"Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease","volume":"60","author":"Pompl","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.arr.2026.103273_bib181","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.4049\/jimmunol.1600035","article-title":"Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation","volume":"197","author":"Primiano","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib182","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.molcel.2012.11.009","article-title":"Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity","volume":"49","author":"Py","year":"2013","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103273_bib183","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2018.02.016","article-title":"NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo","volume":"114","author":"Qi","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.arr.2026.103273_bib184","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11011-018-0348-6","article-title":"Intracerebroventricular injection of resveratrol ameliorated A\u03b2-induced learning and cognitive decline in mice","volume":"34","author":"Qi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2026.103273_bib185","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1038\/s41467-021-25033-4","article-title":"TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation","volume":"12","author":"Qin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib186","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.arr.2026.103273_bib187","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat2738","article-title":"Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis","volume":"3","author":"Rathkey","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib188","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","article-title":"Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease","volume":"14","author":"Reddy","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib189","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41598-018-19577-7","article-title":"Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks","volume":"8","author":"Reinhardt","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103273_bib190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib191","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-019-1645-7","article-title":"IL-1\u03b2-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia","volume":"16","author":"Rivera-Escalera","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib192","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13024-020-00396-2","article-title":"P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice","volume":"15","author":"Ruan","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2026.103273_bib193","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12951-022-01524-4","article-title":"Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition","volume":"20","author":"Ruan","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.arr.2026.103273_bib194","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"R\u00fchl","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib195","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-021-02329-2","article-title":"Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease","volume":"18","author":"Rui","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib196","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.4049\/jimmunol.0803612","article-title":"Activation of microglia by amyloid {beta} requires P2X7 receptor expression","volume":"182","author":"Sanz","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib197","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41419-022-04758-0","article-title":"AGE-TXNIP axis drives inflammation in Alzheimer's by targeting A\u03b2 to mitochondria in microglia","volume":"13","author":"Sbai","year":"2022","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103273_bib198","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.14336\/AD.2021.0122","article-title":"Promising intervention approaches to potentially resolve neuroinflammation and steroid hormones alterations in Alzheimer's disease and its neuropsychiatric symptoms","volume":"12","author":"Scassellati","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2026.103273_bib199","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.arr.2026.103273_bib200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1074\/jbc.C115.700492","article-title":"A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation","volume":"291","author":"Schmid-Burgk","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103273_bib201","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1074\/jbc.M110.139048","article-title":"Sodium overload and water influx activate the NALP3 inflammasome","volume":"286","author":"Schorn","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103273_bib202","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tcb.2009.09.008","article-title":"Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?","volume":"20","author":"Sesti","year":"2010","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib203","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neures.2018.06.002","article-title":"Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse","volume":"143","author":"Shang","year":"2019","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.arr.2026.103273_bib204","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11011-021-00886-2","article-title":"Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease","volume":"37","author":"Shao","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2026.103273_bib205","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib206","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib207","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000524236","article-title":"Catalpol alleviates isoflurane-induced hippocampal learning and memory dysfunction and neuropathological changes in aged mice","volume":"29","author":"Shi","year":"2022","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.arr.2026.103273_bib208","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib209","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102981","article-title":"Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis","volume":"114","author":"Shim","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103273_bib211","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103273_bib212","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-020-01948-5","article-title":"\u03b2-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology","volume":"17","author":"Shippy","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib213","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: The TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.arr.2026.103273_bib214","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2007.10.051","article-title":"Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons","volume":"1188","author":"Soiampornkul","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib215","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","article-title":"NLRP3 phosphorylation is an essential priming event for inflammasome activation","volume":"68","author":"Song","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103273_bib216","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo","volume":"137","author":"Stancu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.arr.2026.103273_bib217","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/glia.24160","article-title":"The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model","volume":"70","author":"Stancu","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.arr.2026.103273_bib218","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fncel.2014.00214","article-title":"Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells","volume":"8","author":"Sutinen","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib219","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1742-2094-9-199","article-title":"Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-\u03b2 production in human neuron-like cells","volume":"9","author":"Sutinen","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib220","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib221","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.348","article-title":"Amyloid-\u03b2 induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease","volume":"5","author":"Tan","year":"2014","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103273_bib222","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2015.02.006","article-title":"Amyloid \u03b2 oligomers induce interleukin-1\u03b2 production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner","volume":"458","author":"Taneo","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib223","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41467-017-00227-x","article-title":"CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation","volume":"8","author":"Tang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib224","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103432","article-title":"Aberrant expression of interleukin-1\u03b2 and inflammasome activation in human malignant gliomas","volume":"9","author":"Tarassishin","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.arr.2026.103273_bib226","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12017-021-08675-x","article-title":"Tranilast, a transient receptor potential vanilloid 2 channel (TRPV2) inhibitor attenuates Amyloid \u03b2-induced cognitive impairment: possible mechanisms","volume":"24","author":"Thapak","year":"2022","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.arr.2026.103273_bib227","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.arr.2026.103273_bib228","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib229","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2026.103273_bib230","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.1073\/pnas.1801802115","article-title":"Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice","volume":"115","author":"Tzeng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103273_bib231","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer's disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib232","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810235","article-title":"TNF-\u03b1 and IL-1\u03b2 modulate blood-brain barrier permeability and decrease Amyloid-\u03b2 peptide efflux in a human blood-brain barrier model","volume":"23","author":"Versele","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103273_bib233","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13142","article-title":"Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease","volume":"33","author":"Vontell","year":"2023","journal-title":"Brain Pathol."},{"key":"10.1016\/j.arr.2026.103273_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146476","article-title":"The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies","volume":"1725","author":"Voulgaropoulou","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2023.11.004","article-title":"Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease","volume":"536","author":"Wang","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.arr.2026.103273_bib236","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1021\/acschemneuro.2c00348","article-title":"CY-09 alleviates the depression-like behaviors via inhibiting NLRP3 inflammasome-mediated neuroinflammation in lipopolysaccharide-induced mice","volume":"13","author":"Wang","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114387","article-title":"miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer's disease","volume":"447","author":"Wang","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib238","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40035-025-00501-9","article-title":"Cyclooxygenase-1 deletion in 5\u2009\u00d7\u2009FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment","volume":"14","author":"Wang","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.arr.2026.103273_bib239","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2019.11.020","article-title":"IL-1R(-\/-) alleviates cognitive deficits through microglial M2 polarization in AD mice","volume":"157","author":"Wang","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.arr.2026.103273_bib240","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1159\/000481753","article-title":"Edaravone attenuates the proinflammatory response in Amyloid-\u03b2-treated microglia by inhibiting NLRP3 inflammasome-mediated IL-1\u03b2 secretion","volume":"43","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.arr.2026.103273_bib241","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00011-020-01355-9","article-title":"The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes","volume":"69","author":"Wang","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.arr.2026.103273_bib242","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/jpet.106.111344","volume":"321","author":"Wannamaker","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib243","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/ajt.16968","article-title":"Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity","volume":"22","author":"Wei","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.arr.2026.103273_bib244","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110181","article-title":"The potential effects of festidinol treatment against the NLRP3 inflammasome and pyroptosis in D-galactose and aluminum chloride-induced Alzheimer's-like pathology in mouse brain","volume":"119","author":"Wongpun","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib245","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1038\/s41467-021-26987-1","article-title":"The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103273_bib246","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106625","article-title":"The NLRP3 inflammasome in depression: Potential mechanisms and therapies","volume":"187","author":"Xia","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.arr.2026.103273_bib247","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13529","article-title":"Inhibiting mtDNA-STING-NLRP3\/IL-1\u03b2 axis-mediated neutrophil infiltration protects neurons in Alzheimer's disease","volume":"57","author":"Xia","year":"2024","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.arr.2026.103273_bib248","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41586-022-05570-8","article-title":"Cryo-EM structures of the active NLRP3 inflammasome disc","volume":"613","author":"Xiao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib249","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.4049\/jimmunol.1700175","article-title":"Cutting Edge: TRAF6 Mediates TLR\/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome","volume":"199","author":"Xing","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib250","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2020.09.015","article-title":"PINK1-mediated mitophagy protects against hepatic ischemia\/reperfusion injury by restraining NLRP3 inflammasome activation","volume":"160","author":"Xu","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib251","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154695","article-title":"Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 \u00d7 Tg-AD transgenic mice","volume":"112","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arr.2026.103273_bib252","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<691::AID-JNR8>3.0.CO;2-3","article-title":"Loss of endosomal\/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis","volume":"52","author":"Yang","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.arr.2026.103273_bib253","doi-asserted-by":"crossref","first-page":"30557","DOI":"10.1021\/acsami.2c06283","article-title":"Multifunctional selenium nanoparticles with different surface modifications ameliorate neuroinflammation through the gut microbiota-NLRP3 inflammasome-brain axis in APP\/PS1 mice","volume":"14","author":"Yang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.arr.2026.103273_bib254","article-title":"\u03b2-hydroxybutyrate alleviates learning and memory impairment through the SIRT1 pathway in D-galactose-injured mice","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib255","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.148206","article-title":"Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS\/autophagy\/NLRP3 signal axis in fibrillar A\u03b2-activated microglia","volume":"1801","author":"Yang","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.arr.2026.103273_bib256","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.biopsych.2008.04.021","article-title":"Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106","volume":"64","author":"Yasuno","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.arr.2026.103273_bib257","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.4049\/jimmunol.1701495","article-title":"Curcumin suppresses IL-1\u03b2 secretion and prevents inflammation through inhibition of the NLRP3 inflammasome","volume":"200","author":"Yin","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib258","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12035-017-0467-9","article-title":"NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer's disease","volume":"55","author":"Yin","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103273_bib259","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103273_bib260","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aaf3036","article-title":"An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells","volume":"352","author":"Zanoni","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103273_bib261","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41593-022-01251-x","article-title":"Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease","volume":"26","author":"Zeng","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib262","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/jcmm.12124","article-title":"Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis","volume":"17","author":"Zhang","year":"2013","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.arr.2026.103273_bib263","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/7807302","article-title":"Jia-Wei-Kai-Xin-San treatment alleviated mild cognitive impairment through anti-inflammatory and antiapoptotic mechanisms in SAMP8 mice","volume":"2023","author":"Zhang","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.arr.2026.103273_bib264","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129093","article-title":"Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B\/NLRP3 signaling pathway","volume":"436","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.arr.2026.103273_bib265","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.intimp.2018.11.026","article-title":"Pseudoginsenoside-F11 attenuates cognitive impairment by ameliorating oxidative stress and neuroinflammation in d\u2011galactose-treated mice","volume":"67","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.arr.2026.103273_bib266","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-024-03325-y","article-title":"Chemerin-9 is neuroprotective in APP\/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of A\u03b2","volume":"22","author":"Zhang","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.arr.2026.103273_bib267","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1111\/cns.14219","article-title":"Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib268","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.1039\/D1FO00876E","article-title":"Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.arr.2026.103273_bib269","article-title":"The role of the effects of autophagy on NLRP3 inflammasome in inflammatory nervous system diseases","volume":"9","author":"Zhao","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.arr.2026.103273_bib270","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1523\/JNEUROSCI.4587-15.2016","article-title":"Disulfiram and diphenhydramine hydrochloride upregulate miR-30a to suppress IL-17-associated autoimmune inflammation","volume":"36","author":"Zhao","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib271","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.721474","article-title":"NLRP3 inflammasome-dependent increases in high mobility group box 1 involved in the cognitive dysfunction caused by Tau-overexpression","volume":"13","author":"Zhao","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib272","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13239","article-title":"Klotho overexpression improves amyloid-\u03b2 clearance and cognition in the APP\/PS1 mouse model of Alzheimer's disease","volume":"19","author":"Zhao","year":"2020","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103273_bib273","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12871-022-01915-y","article-title":"Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome","volume":"22","author":"Zheng","year":"2022","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.arr.2026.103273_bib274","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70497","article-title":"Electroacupuncture attenuates high-fat diet-exacerbated Alzheimer's pathology by enhancing TFEB\/TFE3-mediated autophagic clearance of Tau and NLRP3 inflammasome in 3xTg mice","volume":"31","author":"Zheng","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib275","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib276","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801230","article-title":"Epigallocatechin-3-gallate attenuates microglial inflammation and neurotoxicity by suppressing the activation of canonical and noncanonical inflammasome via TLR4\/NF-\u03baB pathway","volume":"63","author":"Zhong","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.arr.2026.103273_bib277","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-025-01695-w","article-title":"Cornuside alleviates cognitive impairments induced by A\u03b2(1-42) through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy","volume":"17","author":"Zhou","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.arr.2026.103273_bib278","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s41232-022-00209-7","article-title":"Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease","volume":"42","author":"Zhou","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.arr.2026.103273_bib279","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103273_bib280","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.629891","article-title":"Enhanced autolysosomal function ameliorates the inflammatory response mediated by the NLRP3 inflammasome in Alzheimer's disease","volume":"13","author":"Zhou","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.arr.2026.103273_bib281","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103273_bib282","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuro.2013.07.007","article-title":"Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats","volume":"38","author":"Zhou","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.arr.2026.103273_bib283","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.trci.2018.09.009","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol with glucose and malate (RGM) to slow the progression of Alzheimer's disease: A pilot study","volume":"4","author":"Zhu","year":"2018","journal-title":"Alzheimers Dement. (N. Y"},{"key":"10.1016\/j.arr.2026.103273_bib284","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1742-2094-11-120","article-title":"Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging","volume":"11","author":"Zimmer","year":"2014","journal-title":"J. Neuroinflamm."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726002655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726002655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:55:24Z","timestamp":1787658924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726002655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":284,"alternative-id":["S1568163726002655"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103273","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the NLRP3 inflammasome in Alzheimer\u2019s disease: Mechanistic insights and therapeutic advances","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103273"}}