{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:53:27Z","timestamp":1791647607107,"version":"4.3.4"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.arr.2026.103312","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:21:37Z","timestamp":1787239297000},"page":"103312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mitochondrial dysfunction in neurodegenerative diseases: Mechanisms and therapeutic advances"],"prefix":"10.1016","volume":"122","author":[{"given":"Zhaomin","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangwa","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-6220","authenticated-orcid":false,"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J."},{"issue":"45","key":"10.1016\/j.arr.2026.103312_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ady9811","article-title":"NAD+ reverses Alzheimer\u2019s neurological deficits via regulating differential alternative RNA splicing of EVA1C","volume":"11","author":"Ai","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2026.103312_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.106051","article-title":"High-intensity interval training outperforms moderate exercise to improve aerobic capacity in patients with recent-onset idiopathic inflammatory myopathies: a multicentre randomised controlled trial","volume":"122","author":"Andreasson","year":"2025","journal-title":"Ebiomedicine"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41398-024-02748-8","article-title":"Synaptic and mitochondrial mechanisms behind alcohol-induced imbalance of excitatory\/inhibitory synaptic activity and associated cognitive and behavioral abnormalities","volume":"14","author":"Arzua","year":"2024","journal-title":"Transl. Psychiatry"},{"issue":"8090","key":"10.1016\/j.arr.2026.103312_bib5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41586-025-09541-7","article-title":"Ribonucleotide incorporation into mitochondrial DNA drives inflammation","volume":"647","author":"Bahat","year":"2025","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib6","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/s42255-025-01390-y","article-title":"Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology","volume":"7","author":"Barnett","year":"2025","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1152\/japplphysiol.00467.2022","article-title":"Two weeks of high-intensity interval training increases skeletal muscle mitochondrial respiration via complex-specific remodeling in sedentary humans","volume":"134","author":"Batterson","year":"2023","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11483","article-title":"Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer\u2019s disease","volume":"7","author":"Beck","year":"2016","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2024.101372","article-title":"Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus in vivo","volume":"32","author":"Begelman","year":"2024","journal-title":"Mol. Ther. Methods & Clin. Dev."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41419-022-04830-9","article-title":"Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload","volume":"13","author":"Bisicchia","year":"2022","journal-title":"Cell. Death & Dis."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107740","article-title":"Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2","volume":"300","author":"Boopathy","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib12","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1364\/BOE.510351","article-title":"Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy","volume":"15","author":"Brenner","year":"2024","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.arr.2026.103312_bib13","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fendo.2024.1182519","article-title":"A randomized feasibility trial of the modified Atkins diet in older adults with mild cognitive impairment due to Alzheimer\u2019s disease","volume":"15","author":"Buchholz","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113311","article-title":"An iPSC-derived neuronal model reveals manganese\u2019s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics","volume":"28","author":"Budinger","year":"2025","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneurol.2014.228","article-title":"Disturbed mitochondrial dynamics and neurodegenerative disorders","volume":"11","author":"Burt\u00e9","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib16","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","article-title":"Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Calvo-Rodriguez","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13024-024-00702-2","article-title":"Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid \u03b2 aggregates in vivo in a mouse model of Alzheimer\u2019s disease","volume":"19","author":"Calvo-Rodriguez","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj7481","article-title":"Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites","volume":"10","author":"Cavallero","year":"2024","journal-title":"Sci. Adv."},{"issue":"52","key":"10.1016\/j.arr.2026.103312_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2528478122","article-title":"Cystathionine \u03b3-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis","volume":"122","author":"Chakraborty","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","article-title":"Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma","volume":"21","author":"Chang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.arr.2026.103312_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102739","article-title":"ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles","volume":"63","author":"Chang","year":"2023","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jacbts.2018.12.005","article-title":"Elamipretide Improves Mitochondrial Function in the Failing Human Heart","volume":"4","author":"Chatfield","year":"2019","journal-title":"JACC Basic Translational Science"},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib23","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/brain\/awaf051","article-title":"Parkinson\u2019s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss","volume":"148","author":"Chemla","year":"2025","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13195-025-01714-w","article-title":"Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP\/PS1 mousmodel of Alzheimer\u2019s disease","volume":"17","author":"Chen","year":"2025","journal-title":"Alzheimer's. Res. & Ther."},{"issue":"20","key":"10.1016\/j.arr.2026.103312_bib25","doi-asserted-by":"crossref","first-page":"14244","DOI":"10.1021\/acs.analchem.0c03506","article-title":"Mitochondria-targeted fluorescent and photoacoustic imaging of hydrogen peroxide in inflammation","volume":"92","author":"Chen","year":"2020","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.arr.2026.103312_bib26","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1007\/s11064-023-03907-x","article-title":"Mitochondrial complex I inhibition in dopaminergic neurons causes altered protein profile and protein oxidation: implications for Parkinson\u2019s disease","volume":"48","author":"Chithra","year":"2023","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12883-024-03603-5","article-title":"A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease","volume":"24","author":"Choi","year":"2024","journal-title":"BMC Neurol."},{"issue":"44","key":"10.1016\/j.arr.2026.103312_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado8307","article-title":"Proteomimetic polymer blocks mitochondrial damage, rescues Huntington\u2019s neurons, and slows onset of neuropathology in vivo","volume":"10","author":"Choi","year":"2024","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib29","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00394-024-03459-y","article-title":"Low thiamine status in adults following low-carbohydrate \/ ketogenic diets: a cross-sectional comparative study of micronutrient intake and status","volume":"63","author":"Churuangsuk","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.arr.2026.103312_bib30","article-title":"An integrated approach to predict activators of NRF2 - the transcription factor for oxidative stress response","volume":"5","author":"Chushak","year":"2024","journal-title":"Artif. Intell. Life Sci."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib31","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/s43587-025-00957-4","article-title":"Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging","volume":"5","author":"Civiletto","year":"2025","journal-title":"Nat. Aging"},{"issue":"29","key":"10.1016\/j.arr.2026.103312_bib32","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1073\/pnas.0403649101","article-title":"Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication","volume":"101","author":"Coskun","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.arr.2026.103312_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00018-023-04819-3","article-title":"Intestinal infection triggers mitochondria-mediated \u03b1-synuclein pathology: relevance to Parkinson\u2019s disease","volume":"80","author":"D. Magalh\u00e3es","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae350","article-title":"Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons","volume":"6","author":"Dafinca","year":"2024","journal-title":"Brain Commun."},{"issue":"38","key":"10.1016\/j.arr.2026.103312_bib35","doi-asserted-by":"crossref","first-page":"15301","DOI":"10.1073\/pnas.1305462110","article-title":"Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria","volume":"110","author":"Daum","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-13683-3","article-title":"Amyloid-\u03b2 impairs mitochondrial dynamics and autophagy in Alzheimer\u2019s disease experimental models","volume":"12","author":"de la Cueva","year":"2022","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.arr.2026.103312_bib37","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/1522-2683(200208)23:15<2525::AID-ELPS2525>3.0.CO;2-I","article-title":"Mass spectrometric identification of mitochondrial oxidative phosphorylation subunits separated by two-dimensional blue-native polyacrylamide gel electrophoresis","volume":"23","author":"Devreese","year":"2002","journal-title":"Electrophoresis"},{"issue":"6759","key":"10.1016\/j.arr.2026.103312_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk3079","article-title":"Altered translation elongation contributes to key hallmarks of aging in the killifish brain","volume":"389","author":"Di Fraia","year":"2025","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.arr.2026.103312_bib39","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.3390\/ijms26167792","article-title":"Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer\u2019s Disease Patients: A Pilot Study","volume":"26","author":"Di Lorenzo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"6756","key":"10.1016\/j.arr.2026.103312_bib40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1126\/science.adn2804","article-title":"ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox","volume":"389","author":"DiGiovanni","year":"2025","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0022-510X(76)90063-0","article-title":"Luft's disease: further biochemical and ultrastructural studies of skeletal muscle in the second case","volume":"27","author":"DiMauro","year":"1976","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib42","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-024-49159-3","article-title":"Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption","volume":"15","author":"Ding","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103312_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103624","article-title":"Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury","volume":"82","author":"Dubey","year":"2025","journal-title":"Redox Biol."},{"issue":"25","key":"10.1016\/j.arr.2026.103312_bib44","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1016\/j.febslet.2005.09.065","article-title":"Structure of dimeric ATP synthase from mitochondria: an angular association of monomers induces the strong curvature of the inner membrane","volume":"579","author":"Dudkina","year":"2005","journal-title":"FEBS Lett."},{"issue":"29","key":"10.1016\/j.arr.2026.103312_bib45","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2503342122","article-title":"NEDD4L induces mitochondrial dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington\u2019s disease","volume":"122","author":"Fan","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib47","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1038\/s41467-024-47867-4","article-title":"Mitochondrial complex I deficiency stratifies idiopathic Parkinson\u2019s disease","volume":"15","author":"Fl\u00f8nes","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib48","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s42003-024-06552-4","article-title":"Early oxidative stress and DNA damage in A\u03b2-burdened hippocampal neurons in an Alzheimer\u2019s-like transgenic rat model","volume":"7","author":"Foret","year":"2024","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib49","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3233\/JAD-131499","article-title":"Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I+ III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease","volume":"39","author":"Francis","year":"2014","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.arr.2026.103312_bib50","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fnagi.2024.1369545","article-title":"Predicting Alzheimer's disease CSF core biomarkers: a multimodal Machine Learning approach","volume":"16","author":"Gaeta","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41392-022-00933-z","article-title":"PINK1-mediated Drp1S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission","volume":"7","author":"Gao","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70730","article-title":"PINK1 deficiency permits the development of Lewy body dementia with coexisting A\u03b2 pathology","volume":"21","author":"Gao","year":"2025","journal-title":"Alzheimer's. & Dement."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib53","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/acs.chemrestox.3c00086","article-title":"Predicting the mitochondrial toxicity of small molecules: insights from mechanistic assays and cell painting data","volume":"36","author":"Garcia de Lomana","year":"2023","journal-title":"Chem. Res. Toxicol."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113418","article-title":"Mitochondrial methylcytosines as blood-based biomarkers for Alzheimer\u2019s disease dementia prognosis","volume":"28","author":"Gasc\u00f3n-Bayarri","year":"2025","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13024-024-00756-2","article-title":"\u03b1-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson\u2019s disease","volume":"19","author":"Geibl","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib56","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41420-025-02790-5","article-title":"Loss of Ezrin triggers mitochondrial dysfunction and oxidative stress, associated with neuronal cell death","volume":"11","author":"Giamundo","year":"2025","journal-title":"Cell. Death Discov."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017225118","article-title":"Hydrogen sulfide is neuroprotective in Alzheimer\u2019s disease by sulfhydrating GSK3\u03b2 and inhibiting Tau hyperphosphorylation","volume":"118","author":"Giovinazzo","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib58","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1096\/fj.15-276907","article-title":"Training intensity modulates changes in PGC-1\u03b1 and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle","volume":"30","author":"Granata","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.arr.2026.103312_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114950","article-title":"Microglial mitochondrial DNA release contributes to neuroinflammation after intracerebral hemorrhage through activating AIM2 inflammasome","volume":"382","author":"Gu","year":"2024","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib60","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12035-025-05419-x","article-title":"Targeting the Rho\/ROCK Signaling Pathway Mitigates Mitochondrial Dysfunction in 6-OHDA-Induced Models of Parkinson\u2019s Disease, Both In Vivo and In Vitro","volume":"63","author":"Guclu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103312_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2025.102077","article-title":"Mitotherapy Restores mitochondrial function and improves cognitive deficits in Alzheimer\u2019s disease","volume":"85","author":"Gupta","year":"2025","journal-title":"Mitochondrion"},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib62","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.3390\/ijms25052454","article-title":"Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NF\u03baB and Mitochondrial Pathways","volume":"25","author":"Gurrea-Rubio","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.arr.2026.103312_bib63","doi-asserted-by":"crossref","first-page":"9532","DOI":"10.3390\/ijms26199532","article-title":"Antioxidant-Enzyme Profiles in Youth Athletes: Associations of SOD and GPX with Exercise and Implications for Endothelial Health","volume":"26","author":"Haferanke","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.arr.2026.103312_bib64","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1016\/j.cmet.2024.07.020","article-title":"Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C.&xa0;elegans.","volume":"36","author":"Hahn","year":"2024","journal-title":"Cell. Metab."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib65","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1139\/apnm-2020-0005","article-title":"PGC-1\u03b1-mediated regulation of mitochondrial function and physiological implications","volume":"45","author":"Halling","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65489-2","article-title":"Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson\u2019s disease brain","volume":"16","author":"H\u00e4llqvist","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14368","article-title":"Ketogenic \u03b2-hydroxybutyrate regulates \u03b2-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice","volume":"24","author":"Han","year":"2025","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103312_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102835","article-title":"Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting","volume":"111","author":"Hong","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib69","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/s41467-025-61046-z","article-title":"A high-fiber diet mimics aging-related signatures of caloric restriction in mammals","volume":"16","author":"Hu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103312_bib70","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.arr.2010.08.006","article-title":"Ageing and neurodegenerative diseases","volume":"9","author":"Hung","year":"2010","journal-title":"Ageing Res. Rev."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116262","article-title":"Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12","volume":"44","author":"Ingersoll","year":"2025","journal-title":"Cell. Rep."},{"issue":"6632","key":"10.1016\/j.arr.2026.103312_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn4705","article-title":"Mitochondria metabolism sets the species-specific tempo of neuronal development","volume":"379","author":"Iwata","year":"2023","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2513837","article-title":"Ketone body \u03b2-hydroxybutyrate prevents myocardial oxidative stress in septic cardiomyopathy","volume":"2022","author":"Ji","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib74","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1038\/s42255-025-01378-8","article-title":"Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and \u03b2-hydroxybutyrylome","volume":"7","author":"Jiang","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.arr.2026.103312_bib75","article-title":"Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis","author":"Jiang","year":"2025","journal-title":"J. Pharm. Anal."},{"issue":"6","key":"10.1016\/j.arr.2026.103312_bib76","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4103\/NRR.NRR-D-23-01051","article-title":"Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2","volume":"20","author":"Jiang","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"12","key":"10.1016\/j.arr.2026.103312_bib77","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3390\/nu16121836","article-title":"Moderate-Intensity Exercise Enhances Mitochondrial Biogenesis Markers in the Skeletal Muscle of a Mouse Model Affected by Diet-Induced Obesity","volume":"16","author":"Jun","year":"2024","journal-title":"Nutrients"},{"issue":"7710","key":"10.1016\/j.arr.2026.103312_bib78","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by DRP1","volume":"558","author":"Kalia","year":"2018","journal-title":"Nature"},{"issue":"46","key":"10.1016\/j.arr.2026.103312_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx7809","article-title":"The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis","volume":"11","author":"Kamerkar","year":"2025","journal-title":"Sci. Adv."},{"issue":"14","key":"10.1016\/j.arr.2026.103312_bib80","doi-asserted-by":"crossref","first-page":"e1212","DOI":"10.1212\/WNL.0000000000005255","article-title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","volume":"90","author":"Karaa","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib81","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12035-025-05612-y","article-title":"ZLN005 Alleviates the Dopaminergic Degeneration via PGC-1\u03b1-Mediated Mitochondrial Homeostasis in Parkinson\u2019s Disease","volume":"63","author":"Kaur","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103312_bib82","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fchem.2022.878835","article-title":"Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[18F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson\u2019s Disease","volume":"10","author":"Kaur","year":"2022","journal-title":"Front. Chem."},{"issue":"6","key":"10.1016\/j.arr.2026.103312_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109994","article-title":"MFN2 coordinates mitochondria motility with \u03b1-tubulin acetylation and this regulation is disrupted in CMT2A","volume":"27","author":"Kumar","year":"2024","journal-title":"Iscience"},{"issue":"4587","key":"10.1016\/j.arr.2026.103312_bib84","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib85","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/27694127.2022.2143214","article-title":"Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy","volume":"1","author":"Lechado-Terradas","year":"2022","journal-title":"Autophagy Rep."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib86","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41467-025-67445-6","article-title":"VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control","volume":"17","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109808","article-title":"Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission","volume":"27","author":"Lhuissier","year":"2024","journal-title":"Iscience"},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib88","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s12031-022-01974-3","article-title":"\u03b2-Hydroxybutyrate Alleviates Low Glucose\u2013Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling","volume":"72","author":"Li","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib89","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s43018-022-00354-5","article-title":"Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition","volume":"3","author":"Li","year":"2022","journal-title":"Nat. Cancer"},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib90","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.tjnut.2023.08.024","article-title":"Hydrogen Sulfide Regulates Glucose Uptake in Skeletal Muscles via S-Sulfhydration of AMPK in Muscle Fiber Type-Dependent Way","volume":"153","author":"Li","year":"2023","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib91","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-023-05595-5","article-title":"PINK1\/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products","volume":"14","author":"Li","year":"2023","journal-title":"Cell. death & Dis."},{"key":"10.1016\/j.arr.2026.103312_bib92","first-page":"2025","article-title":"Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle","volume":"16","author":"Li","year":"2025","journal-title":"Front. Physiol."},{"issue":"46","key":"10.1016\/j.arr.2026.103312_bib93","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu0726","article-title":"CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology","volume":"11","author":"Liao","year":"2025","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002313","article-title":"Significant decrease of maternal mitochondria carryover using optimized spindle-chromosomal complex transfer","volume":"21","author":"Liao","year":"2023","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.arr.2026.103312_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2025.103992","article-title":"Mitochondrial fission and fusion in neurodegenerative diseases:Ca2+ signalling","volume":"132","author":"Liu","year":"2025","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103312_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2024.04.009","article-title":"Mitochondrial DNA leakage and cGas\/STING pathway in microglia: crosstalk between neuroinflammation and neurodegeneration","volume":"548","author":"Liu","year":"2024","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-46776-8","article-title":"Ketone body \u03b2-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics","volume":"13","author":"Llorente-Folch","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib98","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s42003-024-06888-x","article-title":"Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging","volume":"7","author":"Long","year":"2024","journal-title":"Commun. Biol."},{"issue":"29","key":"10.1016\/j.arr.2026.103312_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt1318","article-title":"Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine","volume":"11","author":"Lou","year":"2025","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib100","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41419-023-06251-8","article-title":"Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization","volume":"14","author":"Lurette","year":"2023","journal-title":"Cell. Death & Dis."},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib101","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41419-023-06261-6","article-title":"Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation","volume":"14","author":"Ma","year":"2023","journal-title":"Cell. Death & Dis."},{"issue":"916","key":"10.1016\/j.arr.2026.103312_bib102","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adp7760","article-title":"Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory","volume":"18","author":"Man","year":"2025","journal-title":"Sci. Signal."},{"key":"10.1016\/j.arr.2026.103312_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.585821","article-title":"SIRT1 and SIRT2 activity control in neurodegenerative diseases","volume":"11","author":"Manjula","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202411276","article-title":"Single-Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite-Gene Correlation Network","volume":"12","author":"Mao","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13024-024-00701-3","article-title":"Mitochondrial CISD1\/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1\/parkin models","volume":"19","author":"Martinez","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"7761","key":"10.1016\/j.arr.2026.103312_bib106","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib107","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1167\/iovs.17-22972","article-title":"SIRT1 and NRF2 gene transfer mediate distinct neuroprotective effects upon retinal ganglion cell survival and function in experimental optic neuritis","volume":"59","author":"McDougald","year":"2018","journal-title":"Invest. Ophthalmol. & Vis. Sci."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib108","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41594-025-01602-9","article-title":"Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration","volume":"32","author":"Miao","year":"2025","journal-title":"Nat. Struct. & Mol. Biol."},{"issue":"6711","key":"10.1016\/j.arr.2026.103312_bib109","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm6131","article-title":"Restoring hippocampal glucose metabolism rescues cognition across Alzheimer\u2019s disease pathologies","volume":"385","author":"Minhas","year":"2024","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib110","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.stemcr.2018.09.007","article-title":"Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy","volume":"11","author":"Monzio Compagnoni","year":"2018","journal-title":"Stem Cell. Rep."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib111","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cmet.2014.07.024","article-title":"Amyloid-\u03b2 peptide induces mitochondrial dysfunction by inhibition of preprotein maturation","volume":"20","author":"Mossmann","year":"2014","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103312_bib112","first-page":"1","article-title":"PGC-1\u03b1 activation boosts exercise-dependent cellular response in the skeletal muscle","author":"Mozaffaritabar","year":"2024","journal-title":"J. Physiol. Biochem."},{"issue":"16","key":"10.1016\/j.arr.2026.103312_bib113","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/cne.24924","article-title":"Region-and neuronal-subtype-specific expression of Na, K-ATPase alpha and beta subunit isoforms in the mouse brain","volume":"528","author":"Murata","year":"2020","journal-title":"J. Comp. Neurol."},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib114","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1007\/s10787-025-01989-3","article-title":"Sodium hydrogen sulfide restores H2S-synthesizing and degrading enzymes to alleviate glial activation after traumatic brain injury in male mice","volume":"33","author":"Nasir","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib115","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.19.3.593","article-title":"Intramitochondrial fibers with DNA characteristics: I. Fixation and electron staining reactions","volume":"19","author":"Nass","year":"1963","journal-title":"J. Cell. Biol."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib116","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1134\/S0006297924070149","article-title":"Differences in the Effect of Beta-Hydroxybutyrate on the Mitochondrial Biogenesis, Oxidative Stress and Inflammation Markers in Tissues from Young and Old Rats","volume":"89","author":"Nesterova","year":"2024","journal-title":"Biochemistry (Moscow)"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib117","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s43856-024-00682-w","article-title":"Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer\u2019s disease in humans","volume":"5","author":"Neth","year":"2025","journal-title":"Commun. Med."},{"issue":"6","key":"10.1016\/j.arr.2026.103312_bib118","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/brain\/awae007","article-title":"Huntington\u2019s disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations","volume":"147","author":"Neueder","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.arr.2026.103312_bib119","article-title":"Ketogenic Diet Reduces Age-Induced Chronic Neuroinflammation in Mice","volume":"2","author":"Nomura","year":"2024","journal-title":"Aging Biol."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib120","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s41593-025-02032-y","article-title":"Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice","volume":"28","author":"Pagano Zottola","year":"2025","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib121","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0349-x","article-title":"Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway","volume":"15","author":"Park","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib122","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3233\/JHD-231511","article-title":"Alterations in Cerebrospinal Fluid Urea Occur in Late Manifest Huntington\u2019s Disease","volume":"13","author":"Pfalzer","year":"2024","journal-title":"J. Huntingt. 's. Dis."},{"key":"10.1016\/j.arr.2026.103312_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102734","article-title":"Impact of diet and exercise on mitochondrial quality and mitophagy in Alzheimer's disease","volume":"108","author":"Pradeepkiran","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib124","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41421-023-00636-x","article-title":"Ketogenic diet-produced \u03b2-hydroxybutyric acid accumulates brain GABA and increases GABA\/glutamate ratio to inhibit epilepsy","volume":"10","author":"Qiao","year":"2024","journal-title":"Cell. Discov."},{"issue":"26","key":"10.1016\/j.arr.2026.103312_bib125","doi-asserted-by":"crossref","first-page":"10790","DOI":"10.1523\/JNEUROSCI.3525-12.2013","article-title":"The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons","volume":"33","author":"Reeve","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103312_bib126","article-title":"Loss-of-function variant of SLC27A3 causes mitochondrial dysfunction and a metabolic neurodevelopmental disorder via impaired fatty acid transport","author":"Rehan Ahmad","year":"2025","journal-title":"J. Human. Genet."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib127","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade8701","article-title":"Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation","volume":"9","author":"Reynolds","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib128","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40478-025-01955-8","article-title":"Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism","volume":"13","author":"Richardson","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib129","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.immuni.2025.08.008","article-title":"Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer","volume":"58","author":"Rivadeneira","year":"2025","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib130","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqad038","article-title":"Computational modeling of substrate-dependent mitochondrial respiration and bioenergetics in the heart and kidney cortex and outer medulla","volume":"4","author":"Sadri","year":"2023","journal-title":"Function"},{"issue":"0","key":"10.1016\/j.arr.2026.103312_bib131","first-page":"eads6674","article-title":"Spatial and morphological organization of mitochondria in neurons across a connectome","volume":"0","author":"Sager","year":"2025","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib132","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41467-019-14132-y","article-title":"Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis","volume":"11","author":"Saini","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103312_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103355","article-title":"Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo","volume":"77","author":"Sato","year":"2024","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.arr.2026.103312_bib134","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/emboj\/19.8.1777","article-title":"Supercomplexes in the respiratory chains of yeast and mammalian mitochondria","volume":"19","author":"Sch\u00e4gger","year":"2000","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib135","doi-asserted-by":"crossref","first-page":"7651","DOI":"10.1038\/s41467-025-62895-4","article-title":"Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria","volume":"16","author":"Serdiuk","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.arr.2026.103312_bib136","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1134\/S0006297924020081","article-title":"Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice","volume":"89","author":"Shabalina","year":"2024","journal-title":"Biochemistry (Moscow)"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib137","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41467-024-55557-4","article-title":"The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis","volume":"16","author":"She","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib138","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40814-022-00970-z","article-title":"Feasibility of an MI-CBT ketogenic adherence program for older adults with mild cognitive impairment","volume":"8","author":"Sheffler","year":"2022","journal-title":"Pilot. Feasibility Stud."},{"issue":"23","key":"10.1016\/j.arr.2026.103312_bib139","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1016\/j.cell.2024.09.029","article-title":"Structural basis of respiratory complex adaptation to cold temperatures","volume":"187","author":"Shin","year":"2024","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib140","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Human. Mol. Genet."},{"key":"10.1016\/j.arr.2026.103312_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110882","article-title":"Impairment of PGC-1\u03b1-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease","volume":"133","author":"Singulani","year":"2020","journal-title":"Exp. Gerontol."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib142","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.immuni.2025.07.024","article-title":"Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer\u2019s disease","volume":"58","author":"Song","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103312_bib143","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nutres.2024.04.002","article-title":"Exercise enhances hepatic mitochondrial structure and function while preventing endoplasmic reticulum stress and metabolic dysfunction-associated steatotic liver disease in mice fed a high-fat diet","volume":"126","author":"Souza-Tavares","year":"2024","journal-title":"Nutr. Res."},{"issue":"9","key":"10.1016\/j.arr.2026.103312_bib144","article-title":"Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury","volume":"5","author":"Sridharan","year":"2024","journal-title":"Cell. Rep. Med."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib145","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/emboj.2008.35","article-title":"Dimer ribbons of ATP synthase shape the inner mitochondrial membrane","volume":"27","author":"Strauss","year":"2008","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66726-4","article-title":"Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer\u2019s risk via ERR\u03b1 dysregulation and energy dyshomeostasis","volume":"16","author":"Sun","year":"2025","journal-title":"Nat. Commun."},{"issue":"31","key":"10.1016\/j.arr.2026.103312_bib147","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn8750","article-title":"PGC-1\u03b1 agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease","volume":"10","author":"Sun","year":"2024","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib148","first-page":"1124","article-title":"Protective effect of hydrogen sulfide is mediated by negative regulation of epigenetic histone acetylation in Parkinson\u2019s disease","volume":"19","author":"Sun","year":"2023","journal-title":"Arch. Med. Sci."},{"issue":"6720","key":"10.1016\/j.arr.2026.103312_bib149","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk9167","article-title":"Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function","volume":"386","author":"Swamynathan","year":"2024","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib150","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1038\/s41467-025-59249-5","article-title":"Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson\u2019s disease","volume":"16","author":"Szeg\u0151","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib151","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-021-00448-1","article-title":"Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer\u2019s disease","volume":"16","author":"Terada","year":"2021","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib152","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41436-020-01006-8","article-title":"A phase 2\/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism","volume":"23","author":"Thompson","year":"2021","journal-title":"Genet. Med."},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111158","article-title":"The node of Ranvier influences the in vivo axonal transport of mitochondria and signaling endosomes","volume":"27","author":"Tosolini","year":"2024","journal-title":"iScience"},{"issue":"11","key":"10.1016\/j.arr.2026.103312_bib154","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41380-023-02251-4","article-title":"Mitochondrial DNA damage triggers spread of Parkinson\u2019s disease-like pathology","volume":"28","author":"Tresse","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.arr.2026.103312_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105781","article-title":"Mitochondrial function and A\u03b2 in Alzheimer's disease postmortem brain","volume":"171","author":"Troutwine","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.arr.2026.103312_bib156","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1038\/s41418-022-01032-w","article-title":"RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria","volume":"29","author":"Tu","year":"2022","journal-title":"Cell. Death & Differ."},{"key":"10.1016\/j.arr.2026.103312_bib157","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00401-020-02234-7","article-title":"Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer\u2019s disease models and human brains","volume":"141","author":"Vaillant-Beuchot","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"45","key":"10.1016\/j.arr.2026.103312_bib158","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203499119","article-title":"Nano-positioning and tubulin conformation contribute to axonal transport regulation of mitochondria along microtubules","volume":"119","author":"Van Steenbergen","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"658","key":"10.1016\/j.arr.2026.103312_bib159","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abk1051","article-title":"Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease","volume":"14","author":"Venkataraman","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.arr.2026.103312_bib160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.heliyon.2023.e16411","article-title":"Anti-proliferation and induction of mitochondria-mediated apoptosis by <em>Garcinia hanburyi<\/em> resin in colorectal cancer cells","volume":"9","author":"Vichitsakul","year":"2023","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.arr.2026.103312_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109078","article-title":"Calcium oscillations optimize the energetic efficiency of mitochondrial metabolism","volume":"27","author":"Voorsluijs","year":"2024","journal-title":"Iscience"},{"key":"10.1016\/j.arr.2026.103312_bib162","first-page":"1","article-title":"CRISPR\/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome","author":"Wang","year":"2021","journal-title":"Sci. China Life Sci."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib163","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A mitigates Alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2\/GPX4 axis activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib164","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41536-023-00315-1","article-title":"Engineered inhaled nanocatalytic therapy for ischemic cerebrovascular disease by inducing autophagy of abnormal mitochondria","volume":"8","author":"Wang","year":"2023","journal-title":"npj Regen. Med."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib165","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41420-023-01690-w","article-title":"Exogenous H2S initiating Nrf2\/GPx4\/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts","volume":"9","author":"Wang","year":"2023","journal-title":"Cell. Death Discov."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib166","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm.3983","article-title":"Parkinson's disease\u2013associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib167","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1039\/D1FO04112F","article-title":"Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics","volume":"13","author":"Wang","year":"2022","journal-title":"Food & Funct."},{"issue":"8","key":"10.1016\/j.arr.2026.103312_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107543","article-title":"BL-918 activates PINK1\/Parkin signaling pathway to ameliorate the progression of Parkinson\u2019s disease","volume":"300","author":"Wang","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103312_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102667","article-title":"Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders","volume":"104","author":"Wen","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"24","key":"10.1016\/j.arr.2026.103312_bib170","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111115","article-title":"BNIP3L\/NIX regulates both mitophagy and pexophagy","volume":"41","author":"Wilhelm","year":"2022","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib171","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3233\/JAD-215280","article-title":"Mitochondrial membrane potential influences amyloid-\u03b2 protein precursor localization and amyloid-\u03b2 secretion","volume":"85","author":"Wilkins","year":"2022","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib172","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nprot.2006.62","article-title":"Blue native PAGE","volume":"1","author":"Wittig","year":"2006","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib173","article-title":"Resveratrol improved mitochondrial biogenesis by activating SIRT1\/PGC-1\u03b1 signal pathway in SAP","volume":"14","author":"Wu","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.arr.2026.103312_bib174","article-title":"Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses","volume":"3","author":"Wu","year":"2023","journal-title":"Cell. Rep. Methods"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib175","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41392-020-00411-4","article-title":"Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis","volume":"6","author":"Xu","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.arr.2026.103312_bib176","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202408166","article-title":"The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria","volume":"224","author":"Yamashita","year":"2025","journal-title":"J. Cell. Biol."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib177","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/s41467-025-67816-z","article-title":"A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis","volume":"17","author":"Yan","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103312_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119425","article-title":"Beneficial effects of the herbal medicine zuo gui wan in a mice model of Alzheimer's disease via Drp1-Mediated inhibition of mitochondrial fission and activation of AMPK\/PGC-1\u03b1-regulated mitochondrial bioenergetics","volume":"342","author":"Yan","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.arr.2026.103312_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117340","article-title":"Scutellarin ameliorates mitochondrial dysfunction and apoptosis in OGD\/R-insulted HT22 cells through mitophagy induction","volume":"179","author":"Yang","year":"2024","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.arr.2026.103312_bib180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2021.12.004","article-title":"Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction","volume":"178","author":"Yang","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib181","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1186\/s12967-023-04763-7","article-title":"Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia-reperfusion injury in heart transplantation","volume":"21","author":"Yuan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib182","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41419-023-05826-9","article-title":"The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo","volume":"14","author":"Z-r","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"18","key":"10.1016\/j.arr.2026.103312_bib183","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3390\/cells14181433","article-title":"Circulating Serum Cell-Free Mitochondrial DNA in Amyotrophic Lateral Sclerosis","volume":"14","author":"Zanini","year":"2025","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.arr.2026.103312_bib184","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1039\/D3SC01427D","article-title":"Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I","volume":"14","author":"Zdorevskyi","year":"2023","journal-title":"Chem. Sci."},{"issue":"16","key":"10.1016\/j.arr.2026.103312_bib185","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1021\/acs.analchem.2c00041","article-title":"Mitochondria-targeted fluorescence\/photoacoustic dual-modality imaging probe tailored for visual precise diagnosis of drug-induced liver injury","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-025-02906-x","article-title":"Melatonin orchestrates mitochondrial fusion dynamics-mediated WNT\/\u03b2-catenin signaling to promote dopaminergic neuronal differentiation of human iPS and nerve regeneration in a MPTP-induced mouse model of Parkinson\u2019s disease","volume":"12","author":"Zhang","year":"2025","journal-title":"Cell. Death Discov."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib187","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/antiox12051062","article-title":"Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein\u2013Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis","volume":"12","author":"Zhang","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.arr.2026.103312_bib188","first-page":"2025","article-title":"Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson\u2019s disease","volume":"17","author":"Zhang","year":"2025","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib189","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12967-025-06212-z","article-title":"Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.arr.2026.103312_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102324","article-title":"Role of histone modifications in neurogenesis and neurodegenerative disease development","author":"Zhao","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib191","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/s11064-020-03003-4","article-title":"Treadmill Exercise Attenuates A\u03b2-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP\/PS1 Transgenic Mice","volume":"45","author":"Zhao","year":"2020","journal-title":"Neurochem. Res."},{"issue":"17","key":"10.1016\/j.arr.2026.103312_bib192","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.3390\/molecules27175545","article-title":"Resveratrol reestablishes mitochondrial quality control in myocardial ischemia\/reperfusion injury through Sirt1\/Sirt3-Mfn2-Parkin-PGC-1\u03b1 pathway","volume":"27","author":"Zheng","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.arr.2026.103312_bib193","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41419-018-0552-7","article-title":"Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK\/MFF\/Drp1 pathway","volume":"9","author":"Zheng","year":"2018","journal-title":"Cell. Death Dis."},{"issue":"10","key":"10.1016\/j.arr.2026.103312_bib194","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3390\/antiox13101226","article-title":"PET Imaging with [18F]ROStrace detects oxidative stress and predicts Parkinson\u2019s disease progression in mice","volume":"13","author":"Zhu","year":"2024","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.arr.2026.103312_bib195","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4783602","article-title":"SS-31 provides neuroprotection by reversing mitochondrial dysfunction after traumatic brain injury","volume":"2018","author":"Zhu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:37:53Z","timestamp":1791646673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726003041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":195,"alternative-id":["S1568163726003041"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103312","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial dysfunction in neurodegenerative diseases: Mechanisms and therapeutic advances","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103312"}}