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USA"},{"key":"10.1016\/j.arr.2026.103319_bib66","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2307\/1310589","article-title":"Why do turtles live so long?","volume":"37","author":"Gibbons","year":"1987","journal-title":"BioScience"},{"key":"10.1016\/j.arr.2026.103319_bib67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.tig.2014.04.007","article-title":"Sirtuins: guardians of mammalian healthspan","volume":"30","author":"Giblin","year":"2014","journal-title":"Trends genetics TIG"},{"key":"10.1016\/j.arr.2026.103319_bib68","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1152\/japplphysiol.00238.2010","article-title":"Epigenetic alterations in aging","volume":"109","author":"Gonzalo","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.arr.2026.103319_bib69","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/1535-7163.MCT-08-0661","article-title":"Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions","volume":"8","author":"Gopal","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.arr.2026.103319_bib70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11357-008-9053-4","article-title":"Rodents for comparative aging studies: from mice to beavers","volume":"30","author":"Gorbunova","year":"2008","journal-title":"Age"},{"key":"10.1016\/j.arr.2026.103319_bib71","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrm1682","article-title":"The actin cytoskeleton: a key regulator of apoptosis and ageing?","volume":"6","author":"Gourlay","year":"2005","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib72","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jm049137g","article-title":"Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells","volume":"48","author":"Grasberger","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.arr.2026.103319_bib73","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1093\/nar\/gkm1065","article-title":"Contributions of DNA interstrand cross-links to aging of cells and organisms","volume":"35","author":"Grillari","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.arr.2026.103319_bib74","first-page":"452","article-title":"Changes in cell membranes during aging","author":"Grinna","year":"1977","journal-title":"Gerontology 23"},{"key":"10.1016\/j.arr.2026.103319_bib75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/path.2104","article-title":"Immunosenescence of ageing","volume":"211","author":"Gruver","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.arr.2026.103319_bib76","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fnut.2024.1445080","article-title":"Polyphenols alleviate metabolic disorders: the role of ubiquitin-proteasome system","volume":"11","author":"Gu","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.arr.2026.103319_bib77","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1101\/sqb.2011.76.010629","article-title":"Sirtuins, aging, and metabolism","volume":"76","author":"Guarente","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib78","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.3389\/fcell.2026.1755668","article-title":"The proteostasis paradox: from systemic collapse in aging to pathway-specific addiction in prostate cancer","volume":"14","author":"Guo","year":"2026","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib79","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103319_bib80","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ncb983","article-title":"Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation","volume":"5","author":"Haglund","year":"2003","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib81","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1021\/cr800544v","article-title":"Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway","volume":"109","author":"Hampton","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.arr.2026.103319_bib82","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cell.2013.01.051","article-title":"Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination","volume":"152","author":"Hao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103319_bib83","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3390\/genes5030656","article-title":"MicroRNAs as Mediators of the Ageing Process","volume":"5","author":"Harries","year":"2014","journal-title":"Genes"},{"key":"10.1016\/j.arr.2026.103319_bib84","doi-asserted-by":"crossref","first-page":"10623","DOI":"10.1128\/JVI.75.22.10623-10629.2001","article-title":"Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction","volume":"75","author":"Harty","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.arr.2026.103319_bib85","doi-asserted-by":"crossref","first-page":"13871","DOI":"10.1073\/pnas.250277297","article-title":"A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding","volume":"97","author":"Harty","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103319_bib86","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103319_bib87","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.159.5.2445","article-title":"Enhanced expression of inducible cyclooxygenase with age in murine macrophages","volume":"159","author":"Hayek","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103319_bib88","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0047-6374(80)90109-8","article-title":"Age-dependence of molecular and functional changes in biological membrane properties","volume":"14","author":"Hegner","year":"1980","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2026.103319_bib89","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/jmcc.1996.0045","article-title":"Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle","volume":"28","author":"Helenius","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.arr.2026.103319_bib90","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1072831","article-title":"Plant development: regulation by protein degradation","volume":"297","author":"Hellmann","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103319_bib91","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ydbio.2015.04.021","article-title":"Identification of HECT E3 ubiquitin ligase family genes involved in stem cell regulation and regeneration in planarians","volume":"404","author":"Henderson","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib92","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/cc.5.1.2266","article-title":"Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo\/p27Kip1 and cyclin E degradation","volume":"5","author":"Higa","year":"2006","journal-title":"Cell. 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Rep."},{"key":"10.1016\/j.arr.2026.103319_bib97","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan","volume":"13","author":"Houtkooper","year":"2012","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib98","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0047-6374(02)00084-2","article-title":"The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid","volume":"123","author":"Hsieh","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2026.103319_bib99","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4161\/cam.4.1.9834","article-title":"Roles of E3 ubiquitin ligases in cell adhesion and migration","volume":"4","author":"Huang","year":"2010","journal-title":"Cell. Adhes. & Migr."},{"key":"10.1016\/j.arr.2026.103319_bib100","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ncb1868","article-title":"Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration","volume":"11","author":"Huang","year":"2009","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib101","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/cdd.2014.115","article-title":"Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila","volume":"21","author":"Huang","year":"2014","journal-title":"Cell. death Differ."},{"key":"10.1016\/j.arr.2026.103319_bib102","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/1947601910382901","article-title":"Ubiquitination-dependent regulation of signaling receptors in cancer","volume":"1","author":"HuangFu","year":"2010","journal-title":"Genes. & Cancer"},{"key":"10.1016\/j.arr.2026.103319_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147602","article-title":"Ubiquitin Ligases in Longevity and Aging Skeletal Muscle","volume":"23","author":"Hughes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103319_bib104","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1097-2765(02)00826-2","article-title":"A conserved RING finger protein required for histone H2B monoubiquitination and cell size control","volume":"11","author":"Hwang","year":"2003","journal-title":"Mol. 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Int."},{"key":"10.1016\/j.arr.2026.103319_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039582","article-title":"Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants","volume":"7","author":"Jarmoszewicz","year":"2012","journal-title":"PloS. One"},{"key":"10.1016\/j.arr.2026.103319_bib109","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ccell.2015.02.006","article-title":"Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies","volume":"27","author":"Jeon","year":"2015","journal-title":"Cancer Cell."},{"key":"10.1016\/j.arr.2026.103319_bib110","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/s12276-023-01087-w","article-title":"Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases","volume":"55","author":"Jeong","year":"2023","journal-title":"Exp. & Mol. Med."},{"key":"10.1016\/j.arr.2026.103319_bib111","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.molcel.2020.12.008","article-title":"Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53","volume":"81","author":"Jiang","year":"2021","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103319_bib112","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4093\/dmj.2014.38.3.171","article-title":"Ubiquitin ligases in cholesterol metabolism","volume":"38","author":"Jiang","year":"2014","journal-title":"Diabetes & Metab. J."},{"key":"10.1016\/j.arr.2026.103319_bib113","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbrc.2016.07.011","article-title":"The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo","volume":"478","author":"Jiang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103319_bib114","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnmol.2016.00093","article-title":"A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?","volume":"9","author":"Joshi","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.arr.2026.103319_bib115","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/jcs.01679","article-title":"Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation","volume":"118","author":"Kaabeche","year":"2005","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.arr.2026.103319_bib116","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/ncb1194","article-title":"Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase","volume":"6","author":"Kamura","year":"2004","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib117","first-page":"5","article-title":"Regulation of cancer stem cells by RING finger ubiquitin ligases","volume":"1","author":"Kang","year":"2014","journal-title":"Stem Cell. Investig."},{"key":"10.1016\/j.arr.2026.103319_bib118","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1158\/0008-5472.CAN-07-6231","article-title":"Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2","volume":"68","author":"Kano","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.arr.2026.103319_bib119","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cmet.2010.05.001","article-title":"With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging","volume":"11","author":"Kapahi","year":"2010","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103319_bib120","doi-asserted-by":"crossref","first-page":"32806","DOI":"10.1073\/pnas.2020197117","article-title":"DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift","volume":"117","author":"Karayel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. 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Biol."},{"key":"10.1016\/j.arr.2026.103319_bib124","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1074\/jbc.M307453200","article-title":"Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum","volume":"279","author":"Kikkert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103319_bib125","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1091\/mbc.e06-09-0787","article-title":"Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking","volume":"18","author":"Kim","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103319_bib126","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.201709072","article-title":"Pathways of cellular proteostasis in aging and disease","volume":"217","author":"Klaips","year":"2018","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib127","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.arr.2010.02.001","article-title":"Protein homeostasis and aging: the importance of exquisite quality control","volume":"10","author":"Koga","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103319_bib128","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.arr.2010.02.001","article-title":"Protein homeostasis and aging: the importance of exquisite quality control","volume":"10","author":"Koga","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103319_bib129","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1128\/MCB.00773-08","article-title":"Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation","volume":"28","author":"Koh","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib130","first-page":"427","article-title":"The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension","volume":"21","author":"Koncarevic","year":"2007","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib131","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/387299a0","article-title":"Regulation of p53 stability by Mdm2","volume":"387","author":"Kubbutat","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103319_bib132","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1474-9726.2011.00675.x","article-title":"Age-related changes in human hematopoietic stem\/progenitor cells","volume":"10","author":"Kuranda","year":"2011","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103319_bib133","doi-asserted-by":"crossref","first-page":"ra32","DOI":"10.1126\/scisignal.2003741","article-title":"A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53","volume":"6","author":"Kurokawa","year":"2013","journal-title":"Sci. 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Mol. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib139","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.devcel.2006.12.002","article-title":"RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination","volume":"12","author":"Li","year":"2007","journal-title":"Dev. Cell."},{"key":"10.1016\/j.arr.2026.103319_bib140","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/cdd.2008.134","article-title":"WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis","volume":"15","author":"Li","year":"2008","journal-title":"Cell. death Differ."},{"key":"10.1016\/j.arr.2026.103319_bib141","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1alpha: a key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. 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Chem."},{"key":"10.1016\/j.arr.2026.103319_bib162","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1242\/jcs.091777","article-title":"HECT and RING finger families of E3 ubiquitin ligases at a glance","volume":"125","author":"Metzger","year":"2012","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.arr.2026.103319_bib163","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1038\/s44318-025-00576-0","article-title":"RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal","volume":"44","author":"Middleton","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2026.103319_bib164","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1128\/MCB.00296-08","article-title":"CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control","volume":"28","author":"Min","year":"2008","journal-title":"Mol. Cell. 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Chem."},{"key":"10.1016\/j.arr.2026.103319_bib182","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1016\/j.febslet.2011.05.005","article-title":"The BRCA1 ubiquitin ligase and homologous recombination repair","volume":"585","author":"Ohta","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2026.103319_bib183","first-page":"1496","article-title":"Principle of marginotomy in template synthesis of polynucleotides","volume":"201","author":"Olovnikov","year":"1971","journal-title":"Dokl. Akad. Nauk. SSSR"},{"key":"10.1016\/j.arr.2026.103319_bib184","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. 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Biol."},{"key":"10.1016\/j.arr.2026.103319_bib186","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1182\/blood-2007-10-115667","article-title":"Itch-\/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice","volume":"111","author":"Parravicini","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.arr.2026.103319_bib187","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/emboj.2009.243","article-title":"Ubiquitin ligase ARF-BP1\/Mule modulates base excision repair","volume":"28","author":"Parsons","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2026.103319_bib188","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/362305a0","article-title":"Optimality, mutation and the evolution of ageing","volume":"362","author":"Partridge","year":"1993","journal-title":"Nat.-Lond."},{"key":"10.1016\/j.arr.2026.103319_bib189","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103319_bib190","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.cell.2011.09.056","article-title":"Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage","volume":"147","author":"Pavlopoulos","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103319_bib191","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2016.03.007","article-title":"Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions","volume":"28","author":"Peng","year":"2016","journal-title":"Mitochondrion"},{"key":"10.1016\/j.arr.2026.103319_bib192","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1097-2765(01)00378-1","article-title":"Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein","volume":"8","author":"Peschard","year":"2001","journal-title":"Mol. 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Sci."},{"key":"10.1016\/j.arr.2026.103319_bib197","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ncb0509-527","article-title":"Viral avoidance and exploitation of the ubiquitin system","volume":"11","author":"Randow","year":"2009","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib198","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s44320-023-00009-2","article-title":"Derailed protein turnover in the aging mammalian brain","volume":"20","author":"Rao","year":"2024","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib199","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1101\/gad.1651408","article-title":"The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells","volume":"22","author":"Rathinam","year":"2008","journal-title":"Genes. & Dev."},{"key":"10.1016\/j.arr.2026.103319_bib200","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1021\/acschembio.9b00621","article-title":"End-Binding E3 Ubiquitin Ligases Enable Protease Signaling","volume":"16","author":"Ravalin","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib201","first-page":"8","article-title":"Age-related differences in cytokine secretion","author":"Riancho","year":"1994","journal-title":"Gerontology 40"},{"key":"10.1016\/j.arr.2026.103319_bib202","first-page":"142","article-title":"Aging of cell communication: loss of receptor function","volume":"39","author":"Robert","year":"2014","journal-title":"Interdiscip. Top. Gerontol."},{"key":"10.1016\/j.arr.2026.103319_bib203","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1038\/s41467-021-23545-7","article-title":"Restoration of energy homeostasis by SIRT6 extends healthy lifespan","volume":"12","author":"Roichman","year":"2021","journal-title":"Nat. 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Chem."},{"key":"10.1016\/j.arr.2026.103319_bib234","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20041103","article-title":"Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1","volume":"384","author":"Suetsugu","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2026.103319_bib235","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cmet.2005.04.010","article-title":"Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)","volume":"1","author":"Sundqvist","year":"2005","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103319_bib236","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","article-title":"WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell mov","volume":"114","author":"Takenawa","year":"2001","journal-title":"ement. J. Cell. Sci."},{"key":"10.1016\/j.arr.2026.103319_bib237","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1074\/jbc.273.11.6439","article-title":"The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells","volume":"273","author":"Talis","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103319_bib238","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.arr.2026.103319_bib239","doi-asserted-by":"crossref","DOI":"10.1016\/S0165-5728(02)00317-X","article-title":"Immune response gene expression increases in the aging murine hippocampus","volume":"132","author":"Terao","year":"2002","journal-title":"J. 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Sci."},{"key":"10.1016\/j.arr.2026.103319_bib243","first-page":"449","article-title":"NF-kappaB in Aging and Disease","volume":"2","author":"Tilstra","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2026.103319_bib244","first-page":"2347","article-title":"Normal brain ageing: models and mechanisms","volume":"360","author":"Toescu","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.arr.2026.103319_bib245","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbamcr.2011.11.015","article-title":"TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells","volume":"1823","author":"Tomar","year":"2012","journal-title":"Biochim. Et. Biophys. 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Lett."},{"key":"10.1016\/j.arr.2026.103319_bib248","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0960-9822(99)80290-5","article-title":"p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27","volume":"9","author":"Tsvetkov","year":"1999","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.arr.2026.103319_bib249","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1091\/mbc.e07-10-0988","article-title":"Ubc4\/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation","volume":"19","author":"Umebayashi","year":"2008","journal-title":"Mol. Biol. 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