{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:24:49Z","timestamp":1794270289075,"version":"4.9.0"},"reference-count":302,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501102"],"award-info":[{"award-number":["82501102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371006"],"award-info":[{"award-number":["82371006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.arr.2026.103348","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:55:41Z","timestamp":1788620141000},"page":"103348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Breaking the self-reinforcing cycle of aging: Biomaterial strategies for aged bone regeneration"],"prefix":"10.1016","volume":"122","author":[{"given":"Yihan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2026.103348_bib1","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiaf117","article-title":"The complex role of neutrophils in healthy aging, inflammaging, and frailty","volume":"117","author":"Abdullah","year":"2025","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101115","article-title":"Telomere transcription in ageing","volume":"62","author":"Aguado","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102832","article-title":"Apheresis for senescence: Targeting the senescence-associated secretory phenotype to delay aging and age-related diseases","volume":"111","author":"Akgun","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib4","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2026.103348_bib5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41586-021-03795-7","article-title":"Aged skeletal stem cells generate an inflammatory degenerative niche","volume":"597","author":"Ambrosi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103348_bib6","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41556-025-01739-1","article-title":"Haematopoietic ageing in health and lifespan","volume":"27","author":"Andersson","year":"2025","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102275","article-title":"Senolytic therapeutics: An emerging treatment modality for osteoarthritis","volume":"96","author":"Ansari","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101854","article-title":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","volume":"85","author":"Armstrong","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11427-023-2305-0","article-title":"Biomarkers of aging","volume":"66","author":"Bao","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.arr.2026.103348_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107943","article-title":"The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy","volume":"230","author":"Basu","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib11","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes. Dev."},{"key":"10.1016\/j.arr.2026.103348_bib12","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.7150\/ijbs.119301","article-title":"Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies","volume":"21","author":"Boaru","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041412","article-title":"Characterization of Naturally Occurring Bioactive Factor Mixtures for Bone Regeneration","volume":"21","author":"Bretschneider","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41580-022-00510-w","article-title":"Ageing and rejuvenation of tissue stem cells and their niches","volume":"24","author":"Brunet","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib15","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/jbmr.4643","article-title":"Similarities Between Disuse and Age-Induced Bone Loss","volume":"37","author":"Buettmann","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41573-025-01212-6","article-title":"Targeting DNA damage in ageing: towards supercharging DNA repair","volume":"24","author":"Bujarrabal-Dueso","year":"2025","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.arr.2026.103348_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2014.03.002","article-title":"AMPK at the nexus of energetics and aging","volume":"20","author":"Burkewitz","year":"2014","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13770","article-title":"Mitochondrial stress and mitokines in aging","volume":"22","author":"Burtscher","year":"2023","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13178","article-title":"Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging","volume":"55","author":"Cai","year":"2022","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.arr.2026.103348_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41580-024-00770-8","article-title":"The role of the haematopoietic stem cell niche in development and ageing","volume":"26","author":"Cain","year":"2025","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abm7524","article-title":"Balancing energy and protein homeostasis at ER-mitochondria contact sites","volume":"15","author":"Carreras-Sureda","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.arr.2026.103348_bib22","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103348_bib23","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2020.12.028","article-title":"Telomeres: history, health, and hallmarks of aging","volume":"184","author":"Chakravarti","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103348_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102268","article-title":"Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations","volume":"96","author":"Chatsirisupachai","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib25","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/jbmr.4171","article-title":"Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease","volume":"35","author":"Chen","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib26","article-title":"Identification of ferroptosis\/autophagy-related genes and potential underlying mechanisms involved in the effect of BMSC senescence on the osteogenic differentiation of aging BMSCs","volume":"12","author":"Chen","year":"2025","journal-title":"Genes. Dis."},{"key":"10.1016\/j.arr.2026.103348_bib27","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41565-025-01972-7","article-title":"An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing","volume":"20","author":"Chen","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.arr.2026.103348_bib28","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4252\/wjsc.v12.i8.776","article-title":"Autophagy in fate determination of mesenchymal stem cells and bone remodeling","volume":"12","author":"Chen","year":"2020","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.arr.2026.103348_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102372","article-title":"Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases","volume":"99","author":"Chen","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11914-025-00927-0","article-title":"Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity","volume":"23","author":"Chen","year":"2025","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.arr.2026.103348_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41413-026-00534-4","article-title":"Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche","volume":"14","author":"Chen","year":"2026","journal-title":"Bone Res."},{"key":"10.1016\/j.arr.2026.103348_bib32","first-page":"325","article-title":"Immunoporosis: The hidden link between aging immune cells and bone fragility","volume":"53","author":"Cheng","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.arr.2026.103348_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102939","article-title":"Telomerase-active urine-derived stem cells: Regenerative solutions for aging","volume":"113","author":"Cheng","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-031-26576-1_3","article-title":"Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases","volume":"103","author":"Chung","year":"2023","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.arr.2026.103348_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113710","article-title":"Current strategies for senescence treatment: Focused on theranostic performance of nanomaterials","volume":"382","author":"Cong","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.arr.2026.103348_bib36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1210\/endrev\/bnae029","article-title":"The IGF System and Aging","volume":"46","author":"Conover","year":"2025","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib37","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041972","article-title":"Telomeres and Telomerase","volume":"18","author":"Cooper","year":"2026","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro-ageing features of the senescent phenotype","volume":"35","author":"Correia-Melo","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2026.103348_bib39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ecl.2022.11.002","article-title":"Age-Associated Abnormalities of Water Homeostasis","volume":"52","author":"Cowen","year":"2023","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"key":"10.1016\/j.arr.2026.103348_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101608","article-title":"Osteocytes in bone aging: Advances, challenges, and future perspectives","volume":"77","author":"Cui","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwae076","article-title":"Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts","volume":"11","author":"Dai","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib42","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib43","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41556-025-01698-7","article-title":"An overview of contemporary theories of ageing","volume":"27","author":"de Magalh\u00e3es","year":"2025","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101596","article-title":"The role of nutrition in inflammaging","volume":"77","author":"Di Giosia","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41413-023-00278-5","article-title":"Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5","volume":"11","author":"Diegel","year":"2023","journal-title":"Bone Res."},{"key":"10.1016\/j.arr.2026.103348_bib46","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1359\/jbmr.071202","article-title":"Impact of glucose-dependent insulinotropic peptide on age-induced bone loss","volume":"23","author":"Ding","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.actbio.2025.12.031","article-title":"Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing","volume":"212","author":"Dong","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2026.103348_bib48","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2024.02.019","article-title":"New frontiers in the cGAS-STING intracellular DNA-sensing pathway","volume":"57","author":"Dvorkin","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.arr.2026.103348_bib49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.arr.2026.103348_bib50","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2020.05.003","article-title":"Classical and Nonclassical Intercellular Communication in Senescence and Ageing","volume":"30","author":"Fafi\u00e1n-Labora","year":"2020","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13426","article-title":"NF-\u03baB\/IKK activation by small extracellular vesicles within the SASP","volume":"20","author":"Fafi\u00e1n-Labora","year":"2021","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12951-026-04138-2","article-title":"Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing","volume":"24","author":"Fan","year":"2026","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.arr.2026.103348_bib53","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103348_bib54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2018.00095","article-title":"Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis","volume":"9","author":"Fessler","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.arr.2009.03.003","article-title":"The coordination of nuclear and mitochondrial communication during aging and calorie restriction","volume":"8","author":"Finley","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cells12131744","article-title":"The Inflammatory Contribution of B-Lymphocytes and Neutrophils in Progression to Osteoporosis","volume":"12","author":"Frase","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103348_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158540","article-title":"Breaking the vicious cycle of cellular senescence and ROS via a mitochondrial-targeted hydrogel for aged bone regeneration","volume":"503","author":"Fu","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.arr.2026.103348_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117737","article-title":"ED-71 alleviates OVX-induced osteoporosis by inhibiting macrophage senescence through SIRT1\/PGC-1\u03b1 pathway: A potential therapeutic approach","volume":"203","author":"Fu","year":"2026","journal-title":"Bone"},{"key":"10.1016\/j.arr.2026.103348_bib59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12016-021-08899-6","article-title":"Immunology of Aging: the Birth of Inflammaging","volume":"64","author":"Fulop","year":"2023","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137612","article-title":"Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated 'outside-in' and 'inside-out' strategy","volume":"693","author":"Gao","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.arr.2026.103348_bib61","article-title":"A galactose-tethered tetraphenylethene prodrug mediated apoptosis of senescent cells for osteoporosis treatment","volume":"11","author":"Gao","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2026.103348_bib62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103348_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101943","article-title":"Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?","volume":"88","author":"Gerosa","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib64","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1002\/jbmr.4426","article-title":"The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults","volume":"36","author":"Ginsberg","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib65","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.14336\/AD.2021.0110","article-title":"Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena","volume":"12","author":"Gonz\u00e1lez-Osuna","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.arr.2026.103348_bib66","doi-asserted-by":"crossref","first-page":"724","DOI":"10.24272\/j.issn.2095-8137.2023.397","article-title":"Skeletal phenotypes and molecular mechanisms in aging mice","volume":"45","author":"Guan","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.arr.2026.103348_bib67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41419-020-03341-9","article-title":"STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-\u03baB signaling pathway","volume":"12","author":"Guo","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103348_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101955","article-title":"Mitochondrial dysfunction in aging","volume":"88","author":"Guo","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2026.103348_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102919","article-title":"A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging","volume":"113","author":"Guvatova","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib71","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cmet.2022.11.005","article-title":"Age-associated remodeling of Tcell immunity and metabolism","volume":"35","author":"Han","year":"2023","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib72","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","volume":"103","author":"Harrington","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.arr.2011.01.002","article-title":"The roles of the sympathetic nervous system in osteoporotic diseases: A review of experimental and clinical studies","volume":"10","author":"He","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib74","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s11658-023-00501-5","article-title":"Cellular senescence in skeletal disease: mechanisms and treatment","volume":"28","author":"He","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.arr.2026.103348_bib75","article-title":"Co-Treatment With rhBMP-2 and Rapamycin Modulates Osteogenic and Adipogenic Differentiation of Senescent Bone Marrow Mesenchymal Stem Cells for Enhanced Bone Regeneration","volume":"13","author":"He","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib76","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/15548627.2025.2469206","article-title":"Lysosomal quality control Review","volume":"21","author":"Henn","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103348_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14258","article-title":"The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NF\u03baB intracrine senescent noncanonical pathway","volume":"23","author":"Herbstein","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib78","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.tcb.2024.10.003","article-title":"Central role of the ER proteostasis network in healthy aging","volume":"35","author":"Hetz","year":"2025","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib79","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41413-025-00401-8","article-title":"3D imaging reveals changes in the neurovascular architecture of the murine calvarium with aging","volume":"13","author":"Horenberg","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.arr.2026.103348_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814241","article-title":"Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence","volume":"24","author":"Hou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib81","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf597","article-title":"Telomeric repeat-containing RNA increases in aged human cells","volume":"53","author":"Hsieh","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.arr.2026.103348_bib82","article-title":"Characterization of mice carrying a conditional TEAD1 allele","volume":"55","author":"Huang","year":"2017","journal-title":"Genesis"},{"key":"10.1016\/j.arr.2026.103348_bib83","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.arr.2026.103348_bib84","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ymthe.2024.02.005","article-title":"M2 macrophages secrete glutamate-containing extracellular vesicles to alleviate osteoporosis by reshaping osteoclast precursor fate","volume":"32","author":"Huang","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib85","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023216118","article-title":"Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis","volume":"118","author":"Huang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103348_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102522","article-title":"Mitochondrial Extracellular Vesicles (mitoEVs): Emerging mediators of cell-to-cell communication in health, aging and age-related diseases","volume":"101","author":"Iorio","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib87","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41392-023-01343-5","article-title":"Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases","volume":"8","author":"Ji","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib88","first-page":"38","article-title":"Immunoregulatory orchestrations in osteoarthritis and mesenchymal stromal cells for therapy","volume":"55","author":"Jiang","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.arr.2026.103348_bib89","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12951-025-03928-4","article-title":"Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis","volume":"24","author":"Jiang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.arr.2026.103348_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102853","article-title":"Telomerase dynamics in stem cells: Unraveling the molecular nexus of cellular aging and regeneration","volume":"112","author":"Jiang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2023.134812","article-title":"A biocompatible adenine-based metal\u2013organic framework for Ca2+ responsive drug delivery","volume":"349","author":"Jing","year":"2023","journal-title":"Mater. Lett."},{"key":"10.1016\/j.arr.2026.103348_bib92","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41580-024-00800-5","article-title":"Telomere function and regulation from mouse models to human ageing and disease","volume":"26","author":"Jones-Weinert","year":"2025","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib93","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.ado0431","article-title":"Human telomere length is chromosome end-specific and conserved across individuals","volume":"384","author":"Karimian","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103348_bib94","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.tibs.2021.12.007","article-title":"Ribosomal DNA and the nucleolus at the heart of aging","volume":"47","author":"Kasselimi","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101468","article-title":"Autophagy and the hallmarks of aging","volume":"72","author":"Kaushik","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib96","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/acel.12597","article-title":"DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age","volume":"16","author":"Kim","year":"2017","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib97","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41574-021-00551-9","article-title":"Autophagy in metabolic disease and ageing","volume":"17","author":"Kitada","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2026.103348_bib98","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.tibs.2021.10.004","article-title":"Molecular mechanisms of heat shock factor 1 regulation","volume":"47","author":"Kmiecik","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib99","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-biochem-082525-050024","article-title":"The Dynamics of Chromatin Replication","volume":"95","author":"Kollenstart","year":"2026","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.arr.2026.103348_bib100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ebiom.2017.03.020","article-title":"Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?","volume":"21","author":"Korolchuk","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2026.103348_bib101","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41392-025-02439-w","article-title":"Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations","volume":"10","author":"Kuzu","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib103","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy Metabolism of the Osteoblast: Implications for Osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib104","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1172\/JCI86477","article-title":"RelA regulates CXCL1\/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis","volume":"126","author":"Lesina","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/joim.13533","article-title":"Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging","volume":"292","author":"Li","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.arr.2026.103348_bib106","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1172\/JCI77716","article-title":"MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib107","first-page":"40","article-title":"Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family","volume":"11","author":"Li","year":"2024","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.arr.2026.103348_bib108","article-title":"Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer","volume":"50","author":"Li","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.arr.2026.103348_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101195","article-title":"TIP60 in aging and neurodegeneration","volume":"64","author":"Li","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib110","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.fmre.2024.12.010","article-title":"Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss","volume":"5","author":"Li","year":"2025","journal-title":"Fundam. Res."},{"key":"10.1016\/j.arr.2026.103348_bib111","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2024.05.209","article-title":"Enhancing bone regeneration and immunomodulation via gelatin methacryloyl hydrogel-encapsulated exosomes from osteogenic pre-differentiated mesenchymal stem cells","volume":"672","author":"Li","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.arr.2026.103348_bib112","article-title":"MitochondrialDNAmediates immunoparalysis of dendritic cells in sepsis viaSTINGsignalling","volume":"55","author":"Li","year":"2022","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.arr.2026.103348_bib113","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13287-023-03393-6","article-title":"Dysregulation of histone modifications in bone marrow mesenchymal stem cells during skeletal ageing: roles and therapeutic prospects","volume":"14","author":"Li","year":"2023","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib114","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13652","article-title":"The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging","volume":"57","author":"Li","year":"2024","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.arr.2026.103348_bib115","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/acsnano.4c14874","article-title":"MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2026.103348_bib116","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202410931","article-title":"Ultrathin ZIF-8 Coating-Reinforced Enzyme Nanoformulation Avoids Lysosomal Degradation for Senile Osteoporosis Therapy","volume":"34","author":"Liang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib117","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14462","article-title":"Effects of Aging on Glucose and Lipid Metabolism in Mice","volume":"24","author":"Lien","year":"2025","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101507","article-title":"Stress and telomere shortening: Insights from cellular mechanisms","volume":"73","author":"Lin","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111451","article-title":"A stem cell aging framework, from mechanisms to interventions","volume":"41","author":"Liu","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103348_bib120","article-title":"Research progress on multidimensional intervention strategies for hyperuricemia: Western medicine, Traditional Chinese Medicine, and emerging therapies","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2026.103348_bib121","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13612","article-title":"Metformin rejuvenates Nap1l2-impaired immunomodulation of bone marrow mesenchymal stem cells via metabolic reprogramming","volume":"57","author":"Liu","year":"2024","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.arr.2026.103348_bib122","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.actbio.2022.08.064","article-title":"Aging exacerbates the morphological and mechanical response of mineralized collagen fibrils in murine cortical bone to disuse","volume":"152","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2026.103348_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114393","article-title":"Fiber scaffolds augment aged bone regeneration by modulating energy metabolism, immunity and angiogenesis","volume":"388","author":"Liu","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.arr.2026.103348_bib124","article-title":"Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer\u2019s disease","volume":"132","author":"Liu","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib125","article-title":"Retuning Mitochondrial Apoptosis\/Mitophagy Balance via SIRT3-Energized and Microenvironment-Modulated Hydrogel Microspheres to Impede Osteoarthritis (Adv. Healthcare Mater. 32\/2023","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib126","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051606","article-title":"OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential","volume":"22","author":"Liu","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.arr.2026.103348_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108850","article-title":"Resetting the aging clock through epigenetic reprogramming: Insights from natural products","volume":"270","author":"Liu","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib128","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2023.03.005","article-title":"Oxylipin-PPAR\u03b3-initiated adipocyte senescence propagates secondary senescence in the bone marrow","volume":"35","author":"Liu","year":"2023","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib129","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41467-026-68387-3","article-title":"Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling","volume":"17","author":"Liu","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103348_bib130","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib131","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1080\/15548627.2020.1839286","article-title":"Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103348_bib132","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.tcb.2024.02.001","article-title":"Translation is an emerging constraint on protein homeostasis in ageing","volume":"34","author":"Llewellyn","year":"2024","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib133","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.150","article-title":"Autophagy in health and disease: From molecular mechanisms to therapeutic target","volume":"3","author":"Lu","year":"2022","journal-title":"MedComm"},{"key":"10.1016\/j.arr.2026.103348_bib134","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1124\/pharmrev.122.000622","article-title":"Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies","volume":"75","author":"Lucas","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136439","article-title":"Sustainable, temperature-tolerant, dual network conductive pressure sensitive adhesive from cellulose and rosin for wearable sensing","volume":"280","author":"Luo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2026.103348_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102024","article-title":"Targeting proteostasis network in osteoporosis: Pathological mechanisms and therapeutic implications","volume":"90","author":"Ma","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124195","article-title":"Ceramic-based biomaterials: Combining regeneration with anti-senescence","volume":"333","author":"Ma","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2026.103348_bib138","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12831","article-title":"The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling","volume":"17","author":"Ma","year":"2018","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib139","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/iej.12997","article-title":"Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp","volume":"52","author":"Mahdee","year":"2019","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.arr.2026.103348_bib140","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s43587-025-00910-5","article-title":"Immune surveillance of senescent cells in aging and disease","volume":"5","author":"Majewska","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.arr.2026.103348_bib141","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-cellbio-120420-094431","article-title":"The AMPK Pathway: Molecular Rejuvenation of Metabolism and Mitochondria","volume":"41","author":"Malik","year":"2025","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib142","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.matbio.2022.06.004","article-title":"Matrix-bound Cyr61\/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging","volume":"111","author":"Marinkovic","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.arr.2026.103348_bib143","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.201610111","article-title":"Telomere-driven diseases and telomere-targeting therapies","volume":"216","author":"Mart\u00ednez","year":"2017","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib144","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41591-018-0030-x","article-title":"Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche","volume":"24","author":"Maryanovich","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103348_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101488","article-title":"DNA methylation in genes associated with the evolution of ageing and disease: A critical review","volume":"72","author":"Mc Auley","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib146","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41574-024-01039-y","article-title":"Skeletal stem and progenitor cells in bone physiology, ageing and disease","volume":"21","author":"Melis","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.arr.2026.103348_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.866627","article-title":"Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy","volume":"10","author":"Meng","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.arr.2026.103348_bib148","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202112104","article-title":"Stress-responsive regulation of extracellular proteostasis","volume":"221","author":"Mesgarzadeh","year":"2022","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib149","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.actbio.2025.03.024","article-title":"DNA as a promising biomaterial for bone regeneration and potential mechanisms of action","volume":"197","author":"Meshry","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2026.103348_bib150","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s11914-023-00832-4","article-title":"Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease","volume":"21","author":"Milovanovic","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.arr.2026.103348_bib151","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","article-title":"Hallmarks of T cell aging","volume":"22","author":"Mittelbrunn","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib152","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib153","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41591-023-02784-9","article-title":"Validation of biomarkers of aging","volume":"30","author":"Moqri","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.arr.2026.103348_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106581","article-title":"3D-printed polyether-ether ketone\/carboxymethyl cellulose scaffolds coated with Zn-Mn doped mesoporous bioactive glass nanoparticles","volume":"156","author":"Mughal","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-981-13-3681-2_2","article-title":"The Immune System and Its Dysregulation with Aging","volume":"91","author":"M\u00fcller","year":"2019","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.arr.2026.103348_bib156","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1474-9726.2012.00795.x","article-title":"A senescent cell bystander effect: senescence-induced senescence","volume":"11","author":"Nelson","year":"2012","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib157","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib158","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1196\/annals.1333.082","article-title":"Advanced glycation end products and bone loss during aging","volume":"1043","author":"Odetti","year":"2005","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib159","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70256","article-title":"The Aging Landscape by scRNAseq of Mesenchymal Lineage Cells in Mouse Bone","volume":"24","author":"Onal","year":"2025","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.arr.2016.05.009","article-title":"Telomere-associated aging disorders","volume":"33","author":"Opresko","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib161","doi-asserted-by":"crossref","first-page":"17031","DOI":"10.1073\/pnas.0905299106","article-title":"Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6\/IL-8 cytokine network","volume":"106","author":"Orjalo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103348_bib162","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.pmbts.2017.05.001","article-title":"Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair","volume":"148","author":"Paiva","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib163","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-pathmechdis-051122-093128","article-title":"Genome Instability and DNA Repair in Somatic and Reproductive Aging","volume":"19","author":"Panier","year":"2024","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.arr.2026.103348_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117048","article-title":"Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice","volume":"182","author":"Paracha","year":"2024","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.arr.2026.103348_bib165","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium metabolism in health and disease","volume":"5","author":"Peacock","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.arr.2026.103348_bib166","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41584-022-00905-1","article-title":"Inflammation and DNA damage: cause, effect or both","volume":"19","author":"Pezone","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.arr.2026.103348_bib167","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/imr.13068","article-title":"Molecular mechanisms controlling age-associated B cells in autoimmunity","volume":"307","author":"Phalke","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib168","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib169","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.arr.2015.08.004","article-title":"Autophagy in bone: Self-eating to stay in balance","volume":"24","author":"Pierrefite-Carle","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bone.2017.12.014","article-title":"Is fatty acid composition of human bone marrow significant to bone health?","volume":"118","author":"Pino","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.arr.2026.103348_bib171","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1039\/C8BM01632A","article-title":"Systemic administration of enzyme-responsive growth factor nanocapsules for promoting bone repair","volume":"7","author":"Qi","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib172","article-title":"DNA Tetrahedron Delivering miR-21-5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis","volume":"13","author":"Qi","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib173","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s12276-022-00899-6","article-title":"Neurovascular coupling in bone regeneration","volume":"54","author":"Qin","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.arr.2026.103348_bib174","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41419-023-05931-9","article-title":"Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling","volume":"14","author":"Quarato","year":"2023","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.arr.2026.103348_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2017.09.026","article-title":"AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species","volume":"21","author":"Rabinovitch","year":"2017","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103348_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/md22040159","article-title":"Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging\" should be added according to the PubMed record","volume":"22","author":"Rahman","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.arr.2026.103348_bib177","article-title":"Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes","volume":"24","author":"Ren","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib178","first-page":"610","article-title":"Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness","volume":"17","author":"Resende-Coelho","year":"2025","journal-title":"Aging"},{"key":"10.1016\/j.arr.2026.103348_bib179","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41576-022-00527-z","article-title":"Genetics of human telomere biology disorders","volume":"24","author":"Revy","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.arr.2026.103348_bib180","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41556-022-00842-x","article-title":"Telomere dysfunction in ageing and age-related diseases","volume":"24","author":"Rossiello","year":"2022","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102391","article-title":"Stem cell-derived extracellular vesicles as senotherapeutics","volume":"99","author":"Rudnitsky","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib182","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11357-021-00341-1","article-title":"Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration","volume":"43","author":"Saberi","year":"2021","journal-title":"Geroscience"},{"key":"10.1016\/j.arr.2026.103348_bib183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.09.001","article-title":"The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process","volume":"48","author":"Salminen","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102044","article-title":"Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective","volume":"91","author":"Salvioli","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib185","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.bbabio.2016.03.018","article-title":"Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?","volume":"1857","author":"Sanz","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2026.103348_bib186","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s12035-021-02640-2","article-title":"Carrying Excess Baggage Can Slowdown Life: Protein Clearance Machineries That Go Awry During Aging and the Relevance of Maintaining Them","volume":"59","author":"Sarkar","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.arr.2026.103348_bib187","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103348_bib188","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41413-023-00303-7","article-title":"Aging impairs the osteocytic regulation of collagen integrity and bone quality","volume":"12","author":"Schurman","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.arr.2026.103348_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101393","article-title":"Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology","volume":"70","author":"Selman","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib190","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1210\/jc.2018-00480","article-title":"Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults","volume":"103","author":"Semba","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib191","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbamcr.2016.01.005","article-title":"miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways","volume":"1863","author":"Shang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2026.103348_bib192","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117077","article-title":"Associations of global biomarkers of oxidative stress with osteoporosis, bone microstructure and bone turnover: Evidence from human and animal studies","volume":"183","author":"Shen","year":"2024","journal-title":"Bone"},{"key":"10.1016\/j.arr.2026.103348_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141555","article-title":"Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells","volume":"506","author":"Sheng","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101458","article-title":"A common signature of cellular senescence; does it exist?","volume":"71","author":"Sikora","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib195","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-med-050124-040555","article-title":"Recent Advances in Osteoporosis Therapeutics","volume":"77","author":"S\u00f8lling","year":"2026","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.arr.2026.103348_bib196","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.actbio.2022.05.041","article-title":"Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats","volume":"147","author":"Sommer","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.arr.2026.103348_bib197","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158446","article-title":"Epigenetics, DNA damage, and aging","volume":"132","author":"Soto-Palma","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib198","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/jbmr.4219","article-title":"Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice","volume":"36","author":"Stegen","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib199","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jbmr\/zjae088","article-title":"The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion","volume":"39","author":"Suh","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2025.106840","article-title":"Substrate stiffness modulates osteogenic differentiation of BMMSCs via the hedgehog signaling pathway","volume":"187","author":"Sun","year":"2025","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib201","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103348_bib202","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The Mitochondrial Basis of Aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103348_bib203","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1068199","article-title":"Potential role of 25(OH)D insufficiency in the dysfunction of glycolipid metabolism and cognitive impairment in patients with T2DM","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.arr.2026.103348_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124061","article-title":"Mitochondrial fusion targeted supramolecular peptide hydrogel for gut neuroprotection","volume":"330","author":"Sun","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2026.103348_bib205","doi-asserted-by":"crossref","first-page":"22141","DOI":"10.1021\/acsnano.5c03023","article-title":"Three-Dimensional Bioprinted Scaffolds Loaded with Multifunctional Magnesium-Based Metal-Organic Frameworks Improve the Senescence Microenvironment Prompting Aged Bone Defect Repair","volume":"19","author":"Sun","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2026.103348_bib206","article-title":"E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity","volume":"9","author":"Sun","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib207","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.gendis.2022.10.030","article-title":"Epigenetic regulation of mesenchymal stem cell aging through histone modifications","volume":"10","author":"Sun","year":"2023","journal-title":"Genes. Dis."},{"key":"10.1016\/j.arr.2026.103348_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in lipid metabolism and related diseases","volume":"84","author":"Sz\u00e1nt\u00f3","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.arr.2026.103348_bib209","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13753","article-title":"Role of autophagy in aging: The good, the bad, and the ugly","volume":"22","author":"Tabibzadeh","year":"2023","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102985","article-title":"Characterizing patterns in causes, risk factors, and life expectancy among the oldest old (aged 95+ years)","volume":"114","author":"Tang","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102773","article-title":"Telomeres as hallmarks of iPSC aging: A review on telomere dynamics during stemness and cellular reprogramming","volume":"109","author":"Tavares-Marcos","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib212","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41576-024-00807-w","article-title":"Epigenetic ageing clocks: statistical methods and emerging computational challenges","volume":"26","author":"Teschendorff","year":"2025","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.arr.2026.103348_bib213","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.molmed.2025.04.001","article-title":"The RB protein: more than a sentry of cell cycle entry","volume":"31","author":"Thangavelu","year":"2025","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2026.103348_bib214","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202408517","article-title":"Tracing Cellular Senescence in Bone: Time-Dependent Changes in Osteocyte Cytoskeleton Mechanics and Morphology","volume":"21","author":"Tilton","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.arr.2026.103348_bib215","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/stem.1699","article-title":"miR-335 correlates with senescence\/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity","volume":"32","author":"Tom\u00e9","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.arr.2026.103348_bib216","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1182\/blood-2014-05-526285","article-title":"Bone marrow failure and the telomeropathies","volume":"124","author":"Townsley","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.arr.2026.103348_bib217","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41584-021-00682-3","article-title":"The endothelium-bone axis in development, homeostasis and bone and joint disease","volume":"17","author":"Tuckermann","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.arr.2026.103348_bib218","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tibs.2024.07.001","article-title":"Cellular oxidants and the proteostasis network: balance between activation and destruction","volume":"49","author":"Ulfig","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib219","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.apsb.2021.01.006","article-title":"Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases","volume":"11","author":"Upadhyay","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.arr.2026.103348_bib220","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-031-66768-8_2","article-title":"Proteasome Activators and Ageing: Restoring Proteostasis Using Small Molecules","volume":"107","author":"Upadhyay","year":"2024","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.arr.2026.103348_bib221","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/imr.13153","article-title":"Neutrophils in aging and aging-related pathologies","volume":"314","author":"Van Avondt","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib222","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S2213-8587(18)30026-3","article-title":"The physiology of endocrine systems with ageing","volume":"6","author":"van den Beld","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.arr.2026.103348_bib223","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/joim.12718","article-title":"Clinical implications of bone marrow adiposity","volume":"283","author":"Veldhuis-Vlug","year":"2018","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.arr.2026.103348_bib224","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1101\/gad.331272.119","article-title":"Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence","volume":"34","author":"Vizioli","year":"2020","journal-title":"Genes. Dev."},{"key":"10.1016\/j.arr.2026.103348_bib225","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/jcsm.12741","article-title":"Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle","volume":"12","author":"Voisin","year":"2021","journal-title":"J. Cachex. Sarcopenia Muscle"},{"key":"10.1016\/j.arr.2026.103348_bib226","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1016\/j.ymthe.2025.06.037","article-title":"Epigenetic networks coordinate DNA methylation across the genome","volume":"33","author":"Wagner","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib227","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/0470868694.ch20","article-title":"A mitochondrial paradigm for degenerative diseases and ageing","volume":"235","author":"Wallace","year":"2001","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.arr.2026.103348_bib228","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib229","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116880","article-title":"Advanced glycation and glycoxidation end products in bone","volume":"176","author":"Wang","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.arr.2026.103348_bib230","article-title":"Mechanical energy-charged navigating pump repair natural vascular scaffolds to reverse osteoporosis","volume":"35","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.arr.2026.103348_bib231","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2106\/JBJS.24.00779","article-title":"Glutamine Promotes Rotator Cuff Healing by Ameliorating Age-Related Osteoporosis","volume":"107","author":"Wang","year":"2025","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.arr.2026.103348_bib232","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14092","article-title":"Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging","volume":"23","author":"Wang","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib233","article-title":"Advances in Science and Technology: Selected peer-reviewed full text papers from the 12th Annual International Conference on Material Science and Engineering (ICMSE 2024","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.arr.2026.103348_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112974","article-title":"The interplay between the immune microenvironment and bone aging: From molecular mechanisms to therapeutic interventions","volume":"212","author":"Wang","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2026.103348_bib235","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1016\/j.scib.2024.10.013","article-title":"Bone aging and extracellular vesicles","volume":"69","author":"Wang","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.arr.2026.103348_bib236","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41392-022-01211-8","article-title":"Epigenetic regulation of aging: implications for interventions of aging and diseases","volume":"7","author":"Wang","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib237","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.apsb.2024.01.008","article-title":"Macrophage senescence in health and diseases","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.arr.2026.103348_bib238","article-title":"Antitumor immunity of alcohol-soluble polysaccharide from Nostoc sphaeroides in non-small cell lung cancer","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.arr.2026.103348_bib239","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCULATIONAHA.125.075567","article-title":"Vascular Aging","volume":"153","author":"Wang","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2026.103348_bib240","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tcb.2024.06.007","article-title":"Immune surveillance of senescence: potential application to age-related diseases","volume":"35","author":"Wang","year":"2025","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib241","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12951-023-02036-5","article-title":"Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy","volume":"21","author":"Wang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.arr.2026.103348_bib242","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1038\/s41467-025-60760-y","article-title":"Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103348_bib243","article-title":"Metal-polyphenol nanocomposite hybrid hydrogel: A multifunctional platform for treating diabetic foot ulcers through metabolic microenvironment reprogramming","volume":"322","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2026.103348_bib244","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116606","article-title":"Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway","volume":"175","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.arr.2026.103348_bib245","article-title":"Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration","volume":"14","author":"Wang","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib246","article-title":"The drug discovery and therapeutic nano-strategies targeting cellular senescence","volume":"35","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.arr.2026.103348_bib247","article-title":"Tunable Enhanced Second-Harmonic Generation in InP-InAsP Quantum Well Nanomembranes","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.arr.2026.103348_bib248","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137043","article-title":"Role of GDF15\/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis","volume":"23","author":"Weng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib249","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jbmr.4494","article-title":"Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk","volume":"37","author":"Whittier","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.arr.2026.103348_bib250","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","article-title":"The metabolic roots of senescence: mechanisms and opportunities for intervention","volume":"3","author":"Wiley","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib251","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","article-title":"Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib252","first-page":"686","article-title":"Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives","volume":"54","author":"Wu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib253","article-title":"Calcium Phosphate Nanoparticle-Immobilized Macrophage-Derived Extracellular Vesicle Nanohybrid Facilitates Diabetic Bone Regeneration","volume":"38","author":"Wu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib254","article-title":"Modified implant with dual functions of antioxidant and extracellular matrix reconstruction for regulating MSCs senescence","volume":"40","author":"Wu","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.arr.2026.103348_bib255","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41580-024-00775-3","article-title":"Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases","volume":"25","author":"Wu","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib256","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.tips.2023.12.002","article-title":"Emerging epigenetic insights into aging mechanisms and interventions","volume":"45","author":"Wu","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib257","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/acsbiomaterials.3c01022","article-title":"Advancing Bone-Targeted Drug Delivery: Leveraging Biological Factors and Nanoparticle Designs to Improve Therapeutic Efficacy","volume":"10","author":"Xiao","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.arr.2026.103348_bib258","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1186\/s12967-025-06892-7","article-title":"Immunoinflammation and post-translational modifications in the aging process","volume":"23","author":"Xiao","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.arr.2026.103348_bib259","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s12016-025-09021-w","article-title":"Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications","volume":"68","author":"Xie","year":"2025","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib260","article-title":"Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways","volume":"11","author":"Xu","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.arr.2026.103348_bib261","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12794","article-title":"MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment","volume":"17","author":"Xu","year":"2018","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103348_bib262","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1021\/acsbiomaterials.3c00090","article-title":"Antisenescence ZIF-8\/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly","volume":"9","author":"Xu","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.arr.2026.103348_bib263","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1038\/s41467-025-59016-6","article-title":"Hydrogels with programmed spatiotemporal mechanical cues for stem cell-assisted bone regeneration","volume":"16","author":"Xue","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103348_bib264","article-title":"Osteoblast-CD4+ CTL Crosstalk Mediated by SIRT1\/DAAM2 Axis Prevents Age-Related Bone Loss\" should be added according to the PubMed record","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.arr.2026.103348_bib265","article-title":"A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis","volume":"33","author":"Yang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.arr.2026.103348_bib266","article-title":"Disrupting tumor homeostasis with an autoamplificatory nanoinducer to augment pyroptosis for efficient immunotherapy","volume":"324","author":"Yang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.arr.2026.103348_bib267","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2023.111877","article-title":"The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice","volume":"216","author":"Yang","year":"2023","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2026.103348_bib268","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/med.22081","article-title":"Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis","volume":"45","author":"Yao","year":"2025","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib269","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113796","article-title":"Extracellular vesicle as therapeutic agents in anti-aging: Mechanistic insights and future potential","volume":"383","author":"Yoon","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.arr.2026.103348_bib270","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.gt.3302234","article-title":"Telomerized presenescent osteoblasts prevent bone mass loss in vivo","volume":"11","author":"Yudoh","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.arr.2026.103348_bib271","doi-asserted-by":"crossref","DOI":"10.1172\/JCI203623","article-title":"Neuroendocrine and neural control of bone mass in health and disease","volume":"136","author":"Zaidi","year":"2026","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib272","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102294","article-title":"Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases","volume":"97","author":"Zeng","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib273","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arr.2015.11.006","article-title":"Ageing and the telomere connection: An intimate relationship with inflammation","volume":"25","author":"Zhang","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib274","article-title":"Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice","volume":"132","author":"Zhang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103348_bib275","doi-asserted-by":"crossref","first-page":"23028","DOI":"10.1021\/acsnano.5c03344","article-title":"Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2026.103348_bib276","first-page":"773","article-title":"Autophagic-active nanosystem for senile bone regeneration by in-situ mitochondrial biogenesis and intercellular transfer","volume":"53","author":"Zhang","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib277","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1039\/D5TB00965K","article-title":"Promoting ROS scavenging and osteogenic differentiation by metal-phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.arr.2026.103348_bib278","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1007\/s12015-022-10348-6","article-title":"Metabolic Regulation: A Potential Strategy for Rescuing Stem Cell Senescence","volume":"18","author":"Zhang","year":"2022","journal-title":"Stem Cell. Rev. Rep."},{"key":"10.1016\/j.arr.2026.103348_bib279","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13287-025-04874-6","article-title":"Senescence of bone marrow mesenchymal stromal cells: a narrative review of mechanisms, functional consequences, and rejuvenation strategies for age-related disorders","volume":"17","author":"Zhang","year":"2025","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib280","article-title":"Fabrication of small-diameter in situ tissue engineered vascular grafts with core\/shell fibrous structure and a one-year evaluation via rat abdominal vessel replacement model","volume":"165","author":"Zhang","year":"2024","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.arr.2026.103348_bib281","first-page":"464","article-title":"Mechanical effects in aging of the musculoskeletal system: Molecular signaling and spatial scale alterations","volume":"52","author":"Zhang","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.arr.2026.103348_bib282","article-title":"Single-cell transcriptome analyses reveal disturbed decidual microenvironment in women of advanced maternal age","volume":"15","author":"Zhang","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.arr.2026.103348_bib283","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41577-024-01112-7","article-title":"Regulation of cGAS-STING signalling and its diversity of cellular outcomes","volume":"25","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib284","article-title":"A Gradient Enamel-Mimetic Composite via Crisscross Assembly of Aligned Hybrid Nanowires for Excellent Mechanical Performance","volume":"37","author":"Zhao","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib285","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41420-025-02886-y","article-title":"Sympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis","volume":"11","author":"Zhao","year":"2025","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.arr.2026.103348_bib286","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.7150\/thno.40103","article-title":"A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2026.103348_bib287","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13287-022-02852-w","article-title":"Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases","volume":"13","author":"Zhao","year":"2022","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib288","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41577-022-00751-y","article-title":"DNA damage and repair in age-related inflammation","volume":"23","author":"Zhao","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.arr.2026.103348_bib289","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molmed.2019.04.008","article-title":"Mitochondrial Regulation of Stem Cells in Bone Homeostasis","volume":"26","author":"Zheng","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.arr.2026.103348_bib290","first-page":"759","article-title":"Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling","volume":"62","author":"Zheng","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib291","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1021\/acsnano.4c17989","article-title":"Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve Rejuvenation","volume":"19","author":"Zheng","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.arr.2026.103348_bib292","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111313","article-title":"The elevated level of IL-1\u03b1 in the bone marrow of aged mice leads to MSC senescence partly by down-regulating Bmi-1","volume":"148","author":"Zheng","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2026.103348_bib293","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.tem.2023.12.009","article-title":"Energy homeostasis in the bone","volume":"35","author":"Zhou","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.arr.2026.103348_bib294","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.148224","article-title":"Aging impairs the Treg-related osteogenic induction process via the PGRN\/EGFR\/PI3K\/AKT axis","volume":"331","author":"Zhou","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.arr.2026.103348_bib295","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/jmcb\/mjab059","article-title":"Membrane dynamics of ATG4B and LC3 in autophagosome formation","volume":"13","author":"Zhou","year":"2022","journal-title":"J. Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103348_bib296","article-title":"Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN\/NR (Nicotinamide mononucleotide \/Nicotinamide riboside) \u2013 possible combination use","volume":"114","author":"Zhou","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103348_bib297","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell. Discov."},{"key":"10.1016\/j.arr.2026.103348_bib298","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41421-025-00853-6","article-title":"Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases","volume":"12","author":"Zhu","year":"2026","journal-title":"Cell. Discov."},{"key":"10.1016\/j.arr.2026.103348_bib299","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-021-00646-9","article-title":"Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention","volume":"6","author":"Zhu","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib300","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.reth.2025.03.012","article-title":"Apoptotic vesicles inhibit bone marrow adiposity via wnt\/\u03b2-catenin signaling","volume":"29","author":"Zhu","year":"2025","journal-title":"Regen. Ther."},{"key":"10.1016\/j.arr.2026.103348_bib301","first-page":"318","article-title":"An \"inside-out\"-guided genetically engineered hydrogel for augmenting aged bone regeneration","volume":"51","author":"Zhu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.arr.2026.103348_bib302","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cell.2025.11.035","article-title":"Next steps in regulatory T cells: Biology and clinical application","volume":"189","author":"Zou","year":"2026","journal-title":"Cell"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:11:55Z","timestamp":1794269515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726003405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":302,"alternative-id":["S1568163726003405"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103348","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breaking the self-reinforcing cycle of aging: Biomaterial strategies for aged bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103348"}}