{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:51:57Z","timestamp":1791661917794,"version":"4.3.4"},"reference-count":174,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","award":["2025scz55"],"award-info":[{"award-number":["2025scz55"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","award":["2024SCZ43"],"award-info":[{"award-number":["2024SCZ43"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.arr.2026.103363","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:48:35Z","timestamp":1788950915000},"page":"103363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The GAIP-interacting protein C-terminal 1 (GIPC1) in health and disease: An update"],"prefix":"10.1016","volume":"122","author":[{"given":"Yifang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2026.103363_bib1","article-title":"The GIPC1-Akt1 pathway is required for the specification of the eye field in mouse embryonic stem cells","volume":"33","author":"A","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.arr.2026.103363_bib2","article-title":"5T4 interacts with TIP-2\/GIPC, a PDZ protein, with implications for metastasis","volume":"290","author":"A, A","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103363_bib3","article-title":"Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport","volume":"33","author":"A, R","year":"2022","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib4","article-title":"A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT\/PCP pathway","volume":"12","author":"A, S","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.arr.2026.103363_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cellsig.2005.08.010","article-title":"RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins","volume":"18","author":"Abramow-Newerly","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.arr.2026.103363_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5483\/BMBRep.2016.49.2.261","article-title":"The role of insulin\/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster","volume":"49","author":"Altintas","year":"2016","journal-title":"BMB Rep."},{"key":"10.1016\/j.arr.2026.103363_bib7","article-title":"Global etiology of bacterial meningitis: a systematic review and meta-analysis","volume":"13","author":"Am","year":"2018","journal-title":"PloS. One"},{"key":"10.1016\/j.arr.2026.103363_bib8","article-title":"Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear","volume":"139","author":"Ap","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.arr.2026.103363_bib9","article-title":"GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells","volume":"32","author":"Ar","year":"2011","journal-title":"Mol. Cells"},{"key":"10.1016\/j.arr.2026.103363_bib10","article-title":"Ovarian cancer-epidemiology, classification, pathogenesis, treatment, and estrogen receptors\u2019 molecular backgrounds","volume":"26","author":"B, S","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103363_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114409","article-title":"GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways","volume":"9","author":"Bhattacharya","year":"2014","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.arr.2026.103363_bib12","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1091\/mbc.10.4.819","article-title":"Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton","volume":"10","author":"Bunn","year":"1999","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib13","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.devcel.2021.03.009","article-title":"SH3BP4 promotes neuropilin-1 and \u03b15-integrin endocytosis and is inhibited by Akt","volume":"56","author":"Burckhardt","year":"2021","journal-title":"Dev. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib14","article-title":"Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development","volume":"5","author":"C, G","year":"2003","journal-title":"Dev. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib15","article-title":"Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis","volume":"29","author":"C, P","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103363_bib16","article-title":"The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy \u2018plus\u2019 phenotype","volume":"135","author":"C, R","year":"2012","journal-title":"Brain a J. Neurol."},{"key":"10.1016\/j.arr.2026.103363_bib17","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.7150\/thno.51739","article-title":"Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac ageing in mice via p53\/PPAR\u03b1 signaling","volume":"11","author":"Cai","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.arr.2026.103363_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015581","article-title":"Therapeutic implications of GIPC1 silencing in cancer","volume":"5","author":"Chittenden","year":"2010","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.arr.2026.103363_bib19","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2017070802","article-title":"Impairment of PPAR\u03b1 and the fatty acid oxidation pathway aggravates renal fibrosis during ageing","volume":"29","author":"Chung","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.arr.2026.103363_bib20","article-title":"Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models","volume":"135","author":"Cj","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2026.103363_bib21","article-title":"BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGF\u03b2 receptor to promote invasion","volume":"24","author":"Cr","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.arr.2026.103363_bib22","article-title":"NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival","volume":"58","author":"D, G","year":"2019","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.arr.2026.103363_bib23","article-title":"Neuropilin-1\/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells","volume":"7","author":"D, V","year":"2009","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib24","article-title":"GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion","volume":"285","author":"D, W","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib25","article-title":"APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction","volume":"26","author":"Dc","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib26","article-title":"APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction","volume":"26","author":"Dc","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib27","doi-asserted-by":"crossref","first-page":"15203","DOI":"10.1073\/pnas.93.26.15203","article-title":"GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G\u03b1i subunits","volume":"93","author":"De\u2009Vries","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103363_bib28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41419-021-03731-7","article-title":"GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma\/paraganglioma","volume":"12","author":"Dong","year":"2021","journal-title":"Cell. Death & Dis."},{"key":"10.1016\/j.arr.2026.103363_bib29","article-title":"An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during ageing","volume":"33","author":"Dr","year":"2013","journal-title":"Journal neuroscience official journal Society Neuroscience"},{"key":"10.1016\/j.arr.2026.103363_bib30","article-title":"Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels","volume":"22","author":"E, F","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103363_bib31","article-title":"Syndecan-4 clustering induces cell migration in a PDZ-dependent manner","volume":"98","author":"E, T","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2026.103363_bib32","article-title":"Intracellular signalling: turning down G-protein signals","volume":"7","author":"Ej","year":"1997","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.arr.2026.103363_bib33","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.bmc.2018.01.012","article-title":"Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics","volume":"26","author":"Erak","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib34","article-title":"Myosin VI, an actin motor for membrane traffic and cell migration","volume":"3","author":"F","year":"2002","journal-title":"Traffic (Cph. Den. )"},{"key":"10.1016\/j.arr.2026.103363_bib35","article-title":"GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling","volume":"15","author":"F, J","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib36","article-title":"GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling","volume":"15","author":"F, J","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib37","article-title":"Endothelial cell-dependent regulation of arteriogenesis","volume":"113","author":"F, M","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2026.103363_bib38","article-title":"Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-\u03b2 receptor III expression","volume":"172","author":"F, S","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.arr.2026.103363_bib39","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1128\/JVI.79.7.4229-4237.2005","article-title":"Human Papillomavirus Type 18 E6 Protein Binds the Cellular PDZ Protein TIP-2\/GIPC, Which Is Involved in Transforming Growth Factor \u03b2 Signaling and Triggers Its Degradation by the Proteasome","volume":"79","author":"Favre-Bonvin","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.arr.2026.103363_bib40","article-title":"Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1\/GIPC\/myosin VI complex","volume":"6","author":"G, S","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.arr.2026.103363_bib41","article-title":"Neuropilin-1 (NRP-1)\/GIPC1 pathway mediates glioma progression","volume":"37","author":"G, Z","year":"2016","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"10.1016\/j.arr.2026.103363_bib42","article-title":"miRNA-124-3p\/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis","volume":"143","author":"G, Z","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.7150\/ijbs.119064","article-title":"GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B\/mTOR\/NF-\u03baB Axis","volume":"22","author":"Gan","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.arr.2026.103363_bib44","article-title":"A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC","volume":"276","author":"Gc","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aag0528","article-title":"The neuropilin 2 isoform NRP2b uniquely supports TGF\u03b2-mediated progression in lung cancer","volume":"10","author":"Gemmill","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.arr.2026.103363_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cmet.2024.10.005","article-title":"Plasma protein-based organ-specific ageing and mortality models unveil diseases as accelerated ageing of organismal systems","volume":"37","author":"Goeminne","year":"2025","journal-title":"Cell. Metab."},{"key":"10.1016\/j.arr.2026.103363_bib47","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/s41388-018-0290-4","article-title":"NRP-1 interacts with GIPC1 and \u03b16\/\u03b24-integrins to increase YAP1\/\u0394Np63\u03b1-dependent epidermal cancer stem cell survival","volume":"37","author":"Grun","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103363_bib48","article-title":"Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects","volume":"9","author":"H","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103363_bib49","article-title":"Cloning and characterization of neuropilin-1-interacting protein: a PSD-95\/Dlg\/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1","volume":"19","author":"H","year":"1999","journal-title":"Journal neuroscience official journal Society Neuroscience"},{"key":"10.1016\/j.arr.2026.103363_bib50","article-title":"Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate","volume":"9","author":"H, K","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.arr.2026.103363_bib51","article-title":"Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors","volume":"572","author":"H, K","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.arr.2026.103363_bib52","article-title":"Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit","volume":"20","author":"H, K","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.arr.2026.103363_bib53","article-title":"Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors","volume":"9","author":"H, K","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2026.103363_bib54","article-title":"Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors","volume":"9","author":"H, K","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2026.103363_bib55","article-title":"Up-regulation of GIPC2 in human gastric cancer","volume":"20","author":"H, K","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.arr.2026.103363_bib56","article-title":"BDNF-mediated neurotransmission relies upon a myosin VI motor complex","volume":"9","author":"H, Y","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.arr.2026.103363_bib57","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nrd1902","article-title":"Exploiting the PI3K\/AKT pathway for cancer drug discovery","volume":"4","author":"Hennessy","year":"2005","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.arr.2026.103363_bib58","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1053\/j.gastro.2011.12.044","article-title":"Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues","volume":"142","author":"Hern\u00e1ndez\u2013Gea","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.arr.2026.103363_bib59","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.arr.2026.103363_bib60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.arr.2026.103363_bib61","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/1673-5374.379018","article-title":"Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications","volume":"19","author":"Huang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.arr.2026.103363_bib62","article-title":"Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif","volume":"15","author":"I, P.-J","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103363_bib63","article-title":"Kermit 2\/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development","volume":"133","author":"J","year":"2006","journal-title":"Development (Cambridge England)"},{"key":"10.1016\/j.arr.2026.103363_bib64","article-title":"Expansion of GGC Repeat in GIPC1 Is Associated with Oculopharyngodistal Myopathy","volume":"106","author":"J, D","year":"2020","journal-title":"Am. J. Human. Genet."},{"key":"10.1016\/j.arr.2026.103363_bib65","article-title":"5\u2019 UTR CGG repeat expansion in GIPC1 is associated with oculopharyngodistal myopathy","volume":"144","author":"J, X","year":"2021","journal-title":"Brain a J. Neurol."},{"key":"10.1016\/j.arr.2026.103363_bib66","article-title":"Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2","volume":"121","author":"J, Y","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103363_bib67","article-title":"Characterization of adverse joint outcomes in patients with osteoarthritis treated with subcutaneous tanezumab","volume":"31","author":"Ja","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.arr.2026.103363_bib68","article-title":"CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment","volume":"108","author":"Ja","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"issue":"2","key":"10.1016\/j.arr.2026.103363_bib69","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1091\/mbc.e03-05-0293","article-title":"Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors","volume":"15","author":"Jeanneteau","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib70","article-title":"Synectin-dependent regulation of arterial maturation","volume":"238","author":"Jm","year":"2009","journal-title":"Dev. Dyn. Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.arr.2026.103363_bib71","article-title":"GIPC mediates the generation of reactive oxygen species and the regulation of cancer cell proliferation by insulin-like growth factor-1\/IGF-1R signaling","volume":"294","author":"Js","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.arr.2026.103363_bib72","article-title":"Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits","volume":"8","author":"K, B","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103363_bib73","article-title":"Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth","volume":"13","author":"K, P","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.arr.2026.103363_bib74","article-title":"dmTGS: Precise Targeted Enrichment Long-Read Sequencing Panel for Tandem Repeat Detection","volume":"71","author":"K, Y","year":"2025","journal-title":"Clin. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib75","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1038\/s41467-018-07543-w","article-title":"Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission","volume":"9","author":"Kamerkar","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103363_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.49","article-title":"Functional proteomics, human genetics and cancer biology of GIPC family members","volume":"45","author":"Katoh","year":"2013","journal-title":"Exp. & Mol. Med."},{"key":"10.1016\/j.arr.2026.103363_bib77","doi-asserted-by":"crossref","DOI":"10.1242\/dev.195008","article-title":"Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds","volume":"148","author":"Kowalczyk","year":"2021","journal-title":"Development (Cambridge England)"},{"key":"10.1016\/j.arr.2026.103363_bib78","article-title":"GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP","volume":"95","author":"L","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103363_bib79","article-title":"GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling","volume":"41","author":"L, W","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103363_bib80","article-title":"Fusion Genes Landscape of Lung Cancer Patients From Inner Mongolia, China","volume":"63","author":"L, Y","year":"2024","journal-title":"Genes. Chromosomes & Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib81","article-title":"GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation","volume":"278","author":"La","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib82","article-title":"GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation","volume":"278","author":"La","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101021","article-title":"Roles of the actin cytoskeleton in ageing and age-associated diseases","volume":"58","author":"Lai","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103363_bib84","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/sj.bjc.6602627","article-title":"Role of insulin-like growth factor 1 receptor signalling in cancer","volume":"92","author":"Larsson","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib85","article-title":"MMP9 potentiates pulmonary metastasis formation","volume":"2","author":"Lc","year":"2002","journal-title":"Cancer Cell."},{"key":"10.1016\/j.arr.2026.103363_bib86","article-title":"A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF","volume":"274","author":"Lh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib87","article-title":"A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF","volume":"274","author":"Lh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib88","article-title":"The role of neuropilins in cancer","volume":"5","author":"Lm","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.arr.2026.103363_bib89","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1091\/mbc.12.3.615","article-title":"GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways","volume":"12","author":"Lou","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib90","article-title":"Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction","volume":"275","author":"M, G","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib91","article-title":"GIPC gene family (Review)","volume":"9","author":"M, K","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.arr.2026.103363_bib92","article-title":"Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis","volume":"57","author":"M, S","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.arr.2026.103363_bib93","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1073\/pnas.1616941114","article-title":"Filopodia formation and endosome clustering induced by mutant plus-end-directed myosin VI","volume":"114","author":"Masters","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103363_bib94","article-title":"Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms","volume":"2","author":"Mc","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.arr.2026.103363_bib95","doi-asserted-by":"crossref","first-page":"R248","DOI":"10.1093\/hmg\/ddaa189","article-title":"Loss of epigenetic polarity is a hallmark of hematopoietic stem cell ageing","volume":"29","author":"Mejia-Ramirez","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.arr.2026.103363_bib96","article-title":"Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma","volume":"66","author":"Mh","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.arr.2026.103363_bib97","article-title":"[GIPC: a new target for therapy in pancreatic adenocarcinoma?]","volume":"91","author":"Mh","year":"2007","journal-title":"Verh. der Dtsch. Ges. fur Pathol."},{"key":"10.1016\/j.arr.2026.103363_bib98","article-title":"Neuropilin and neuropilin associated molecules as new molecular targets in pancreatic adenocarcinoma","volume":"11","author":"Mh","year":"2011","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib99","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/acel.12213","article-title":"Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity","volume":"13","author":"Milman","year":"2014","journal-title":"Ageing Cell."},{"key":"10.1016\/j.arr.2026.103363_bib100","article-title":"A new family of G-protein regulators - the RGS proteins","volume":"9","author":"Mr","year":"1997","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib101","article-title":"Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK","volume":"50","author":"Ms","year":"2011","journal-title":"Genes. Chromosomes & Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib102","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1158\/1078-0432.CCR-08-2837","article-title":"Targeting GIPC\/Synectin in Pancreatic Cancer Inhibits Tumor Growth","volume":"15","author":"Muders","year":"2009","journal-title":"Clinical cancer research official journal American Association Cancer Research"},{"key":"10.1016\/j.arr.2026.103363_bib103","article-title":"Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human","volume":"2","author":"N, C","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103363_bib104","article-title":"Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation","volume":"52","author":"N, Q","year":"2022","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.arr.2026.103363_bib105","article-title":"The cytoplasmic domain of TGF\u03b2R3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior","volume":"358","author":"Ns","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib106","article-title":"Endoglin regulates PI3-kinase\/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis","volume":"23","author":"Ny","year":"2012","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib107","article-title":"Endoglin promotes transforming growth factor beta-mediated Smad 1\/5\/8 signaling and inhibits endothelial cell migration through its association with GIPC","volume":"283","author":"Ny","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib108","article-title":"Endoglin promotes transforming growth factor beta-mediated Smad 1\/5\/8 signaling and inhibits endothelial cell migration through its association with GIPC","volume":"283","author":"Ny","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib109","article-title":"Chemiluminescent optical fiber immunosensor for detection of autoantibodies to ovarian and breast cancer-associated antigens","volume":"22","author":"O","year":"2007","journal-title":"Biosens. & Bioelectron."},{"key":"10.1016\/j.arr.2026.103363_bib110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ ageing signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103363_bib111","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/cells8080895","article-title":"Therapeutic Targeting of the IGF Axis","volume":"8","author":"Osher","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103363_bib112","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and Reverse Cholesterol Transport: Basic Mechanisms and their Roles in Vascular Health and Disease","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2026.103363_bib113","article-title":"OPA1 mutations induce mitochondrial DNA instability and optic atrophy \u2018plus\u2019 phenotypes","volume":"131","author":"P, A.-B","year":"2008","journal-title":"Brain a J. Neurol."},{"key":"10.1016\/j.arr.2026.103363_bib114","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/cb200536r","article-title":"Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer","volume":"7","author":"Patra","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcancer.2024.08.002","article-title":"AMPK: The energy sensor at the crossroads of ageing and cancer","volume":"106\u2013107","author":"Penugurti","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.arr.2026.103363_bib116","article-title":"RGS19 enhances cell proliferation through its C-terminal PDZ motif","volume":"22","author":"Ph","year":"2010","journal-title":"Cell. Signal."},{"key":"10.1016\/j.arr.2026.103363_bib117","article-title":"Oculopharyngodistal myopathy with CGG repeat expansions in GIPC1: the first report from southwestern China","volume":"43","author":"R, A","year":"2022","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"10.1016\/j.arr.2026.103363_bib118","article-title":"Interaction of hepatitis B virus core protein with human GIPC1","volume":"155","author":"R, R","year":"2010","journal-title":"Arch. Virol."},{"key":"10.1016\/j.arr.2026.103363_bib119","article-title":"The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins","volume":"16","author":"R, R","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103363_bib120","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/293893","article-title":"Mitochondrial Fusion Proteins and Human Diseases","volume":"2013","author":"Ranieri","year":"2013","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.arr.2026.103363_bib121","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1091\/mbc.e04-11-0978","article-title":"GLUT1CBP(TIP2\/GIPC1) Interactions with GLUT1 and Myosin VI: Evidence Supporting an Adapter Function for GLUT1CBP","volume":"16","author":"Reed","year":"2005","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib122","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI39837","article-title":"ERK1\/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish","volume":"120","author":"Ren","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2026.103363_bib123","article-title":"TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes","volume":"454","author":"Rh","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.arr.2026.103363_bib124","doi-asserted-by":"crossref","DOI":"10.1093\/biolre\/ioag031","article-title":"Myosin VI is involved in the structural organization and molecular composition of epididymal epithelial cells in mouse\u2020","author":"Richert","year":"2026","journal-title":"Biol. Reprod. ioag031"},{"key":"10.1016\/j.arr.2026.103363_bib125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/1471-2407-8-248","article-title":"A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen","volume":"8","author":"Rudchenko","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib126","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2478\/bjmg-2014-0070","article-title":"Genome-wide methylation profiling of schizophrenia","volume":"17","author":"Rukova","year":"2014","journal-title":"Balk. J. Med. Genet."},{"key":"10.1016\/j.arr.2026.103363_bib127","article-title":"Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"S, J","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.arr.2026.103363_bib128","article-title":"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor","volume":"92","author":"S, S","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103363_bib129","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the ageing process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103363_bib130","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41576-022-00477-6","article-title":"Making sense of the ageing methylome","volume":"23","author":"Seale","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.arr.2026.103363_bib131","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fncel.2020.00200","article-title":"IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer\u2019s Disease Transgenic Mouse Model","volume":"14","author":"Sohrabi","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.arr.2026.103363_bib132","article-title":"Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia","volume":"22","author":"Sq","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.arr.2026.103363_bib133","article-title":"CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis","volume":"77","author":"Ss","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib134","article-title":"CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis","volume":"77","author":"Ss","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib135","doi-asserted-by":"crossref","unstructured":"Stancu, A.L. AMPK activation can delay ageing. Discoveries (Craiova) 3, e53.","DOI":"10.15190\/d.2015.45"},{"key":"10.1016\/j.arr.2026.103363_bib136","article-title":"The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell\u2019s response to LPA","volume":"7","author":"T","year":"2012","journal-title":"PloS. One"},{"key":"10.1016\/j.arr.2026.103363_bib137","article-title":"GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR","volume":"278","author":"T, H","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib138","article-title":"GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR","volume":"278","author":"T, H","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib139","article-title":"A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor","volume":"276","author":"T, L","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib140","article-title":"GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR\/PI3K\/AKT signaling","volume":"32","author":"T, L","year":"2023","journal-title":"Oncol. Res."},{"key":"10.1016\/j.arr.2026.103363_bib141","article-title":"Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2","volume":"20","author":"T, S","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.arr.2026.103363_bib142","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-026-01679-9","article-title":"GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM)","author":"Tang","year":"2026","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.arr.2026.103363_bib143","article-title":"PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)","volume":"276","author":"Tf","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib144","article-title":"PDZ interaction sites in integrin alpha subunits. T14853, TIP\/GIPC binds to a type I recognition sequence in alpha 6A\/alpha 5 and a novel sequence in alpha 6B","volume":"276","author":"Tt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103363_bib145","article-title":"Selective regulation of arterial branching morphogenesis by synectin","volume":"10","author":"Tw","year":"2006","journal-title":"Dev. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib146","article-title":"Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment","volume":"72","author":"U, Y","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.arr.2026.103363_bib147","article-title":"GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a \u03b21-Integrin Pathway","volume":"10","author":"U, Y","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.arr.2026.103363_bib148","article-title":"Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease","volume":"8","author":"V, P","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103363_bib149","article-title":"Adenoviral dominant-negative soluble PDGFR\u03b2 improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats","volume":"57","author":"V, R","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.arr.2026.103363_bib150","article-title":"Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary","volume":"8","author":"V, Y","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib151","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1091\/mbc.9.5.1123","article-title":"RGS-GAIP, a GTPase-activating Protein for G\u03b1i Heterotrimeric G Proteins, Is Located on Clathrin-coated Vesicles","volume":"9","author":"Vries","year":"1998","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib152","doi-asserted-by":"crossref","DOI":"10.1158\/1541-7786.MCR-10-0209","article-title":"RGS-GAIP\u2013interacting protein controls breast cancer progression","volume":"8","author":"Wang","year":"2010","journal-title":"Molecular cancer research MCR"},{"key":"10.1016\/j.arr.2026.103363_bib153","article-title":"Scavenger Receptor Class B, Type 1 Facilitates Cellular Fatty Acid Uptake","volume":"1865","author":"Wang","year":"2019","journal-title":"Biochim. Et. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"10.1016\/j.arr.2026.103363_bib154","doi-asserted-by":"crossref","first-page":"11919","DOI":"10.1523\/JNEUROSCI.3852-11.2012","article-title":"Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase\/Akt pathway","volume":"32","author":"Wang","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.arr.2026.103363_bib155","doi-asserted-by":"crossref","DOI":"10.1172\/JCI189029","article-title":"Reinvigorating drug development around NGF signaling for pain","volume":"135","author":"Wangzhou","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.arr.2026.103363_bib156","article-title":"GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways","volume":"12","author":"X","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.arr.2026.103363_bib157","article-title":"GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin\u2019s function","volume":"13","author":"X","year":"2002","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"10.1016\/j.arr.2026.103363_bib158","article-title":"G protein-coupled receptors participate in cytokinesis","volume":"69","author":"X","year":"2012","journal-title":"Cytoskelet. (Hoboken N. J. )"},{"key":"10.1016\/j.arr.2026.103363_bib159","article-title":"A review of the mechanisms underlying the role of the GIPC3 gene in hereditary deafness","volume":"14","author":"X, L","year":"2023","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.arr.2026.103363_bib160","article-title":"Overexpressing of the GIPC1 protects against pathological cardiac remodelling","volume":"971","author":"X, S","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.arr.2026.103363_bib161","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-024-02107-5","article-title":"Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines","volume":"10","author":"Xiao","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.arr.2026.103363_bib162","article-title":"GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma\/paraganglioma","volume":"12","author":"Y, D","year":"2021","journal-title":"Cell. Death & Dis."},{"key":"10.1016\/j.arr.2026.103363_bib163","article-title":"GIPC1 CGG repeat expansion is associated with movement disorders","volume":"91","author":"Y, F","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.arr.2026.103363_bib164","article-title":"Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration","volume":"184","author":"Y, G","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.arr.2026.103363_bib165","article-title":"G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7","volume":"28","author":"Y, L","year":"2022","journal-title":"CNS Neurosci. & Ther."},{"key":"10.1016\/j.arr.2026.103363_bib166","article-title":"Assessment of GGC repeat expansion in GIPC1 in patients with parkinson\u2019s disease","volume":"37","author":"Y, P","year":"2022","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.arr.2026.103363_bib167","unstructured":"Y, Tet al. Unraveling dynamic activities of autocrine pathways that control drug-response transcriptome networks. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing https:\/\/pubmed.ncbi.nlm.nih.gov\/19209706\/ (2009)."},{"key":"10.1016\/j.arr.2026.103363_bib168","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome biogenesis: regulation and functions","volume":"220","author":"Yang","year":"2021","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103363_bib169","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1471-2407-8-247","article-title":"Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary","volume":"8","author":"Yavelsky","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.arr.2026.103363_bib170","article-title":"Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7","volume":"58","author":"Yh","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103363_bib171","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1073\/pnas.0400400101","article-title":"Lessons from border cell migration in the Drosophila ovary: a role for myosin VI in dissemination of human ovarian cancer","volume":"101","author":"Yoshida","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.arr.2026.103363_bib172","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103363_bib173","article-title":"The role of the PDZ protein GIPC in regulating NMDA receptor trafficking","volume":"27","author":"Z, Y","year":"2007","journal-title":"J. Neurosci. Official J. Soc. Neurosci."},{"key":"10.1016\/j.arr.2026.103363_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100616","article-title":"The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake","volume":"296","author":"Zhang","year":"2021","journal-title":"J. Biol. Chem."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:43:19Z","timestamp":1791661399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726003557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":174,"alternative-id":["S1568163726003557"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103363","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The GAIP-interacting protein C-terminal 1 (GIPC1) in health and disease: An update","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103363"}}