{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:54:14Z","timestamp":1791647654853,"version":"4.3.4"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015946","name":"Key Laboratory of Medical Electrophysiology of Ministry of Education","doi-asserted-by":"publisher","award":["KeyME-2022-01"],"award-info":[{"award-number":["KeyME-2022-01"]}],"id":[{"id":"10.13039\/501100015946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.arr.2026.103364","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:35:36Z","timestamp":1789540536000},"page":"103364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NAA10 and NAA15 mutations in cardiovascular disorders: Recent advances and mechanistic insights"],"prefix":"10.1016","volume":"122","author":[{"given":"Yuting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arr.2026.103364_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a005868","article-title":"NAA10 variant in 38-week-gestation male patient: a case study","volume":"6","author":"Afrin","year":"2020","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"key":"10.1016\/j.arr.2026.103364_bib2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.tibs.2016.07.005","article-title":"First things first: vital protein marks by N-terminal acetyltransferases","volume":"41","author":"Aksnes","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.arr.2026.103364_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.molcel.2019.02.007","article-title":"Co-translational, Post-translational, and Non-catalytic Roles of N-terminal acetyltransferases","volume":"73","author":"Aksnes","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103364_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20041071","article-title":"Identification and characterization of the human ARD1-NATH protein acetyltransferase complex","volume":"386","author":"Arnesen","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.arr.2026.103364_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2091-7-13","article-title":"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase","volume":"7","author":"Arnesen","year":"2006","journal-title":"BMC Biochem."},{"key":"10.1016\/j.arr.2026.103364_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2091-10-15","article-title":"A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)","volume":"10","author":"Arnesen","year":"2009","journal-title":"BMC Biochem."},{"key":"10.1016\/j.arr.2026.103364_bib7","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1128\/MCB.01199-09","article-title":"The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation","volume":"30","author":"Arnesen","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib8","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1073\/pnas.0901931106","article-title":"Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans","volume":"106","author":"Arnesen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.arr.2026.103364_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12881-020-01091-1","article-title":"Severe syndromic ID and skewed X-inactivation in a girl with NAA10 dysfunction and a novel heterozygous de novo NAA10 p.(His16Pro) variant - a case report","volume":"21","author":"Bader","year":"2020","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103727","article-title":"N-alpha-acetylation of alpha-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation","volume":"9","author":"Bartels","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.arr.2026.103364_bib11","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.122.061864","article-title":"Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells","volume":"148","author":"Belbachir","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.arr.2026.103364_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209464","article-title":"Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation","volume":"16","author":"Bienvenut","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib13","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.015131","article-title":"Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features","volume":"11","author":"Bienvenut","year":"2012","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.arr.2026.103364_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.a.64096","article-title":"Cardiological Manifestations in Males and Females Affected by NAA10 -Related Disease","volume":"197","author":"Bottillo","year":"2025","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.arr.2026.103364_bib15","first-page":"S4","article-title":"Dyslipidemia and the Current State of Cardiovascular Disease: Epidemiology, Risk Factors, and Effect of Lipid Lowering","volume":"40","author":"Brunham","year":"2024","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.arr.2026.103364_bib16","article-title":"The role of Nalpha-terminal acetylation in protein conformation","author":"Calis","year":"2024","journal-title":"FEBS J."},{"key":"10.1016\/j.arr.2026.103364_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep16022","article-title":"NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment","volume":"5","author":"Casey","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103364_bib18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ajhg.2018.03.004","article-title":"Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies","volume":"102","author":"Cheng","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib19","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1093\/hmg\/ddz111","article-title":"Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15","volume":"28","author":"Cheng","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.canlet.2018.06.033","article-title":"N-alpha-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas","volume":"433","author":"Chien","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.arr.2026.103364_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41467-020-14584-7","article-title":"Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK","volume":"11","author":"Deng","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.gene.2015.04.085","article-title":"The biological functions of Naa10 - From amino-terminal acetylation to human disease","volume":"567","author":"Dorfel","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.arr.2026.103364_bib23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bbapap.2016.06.007","article-title":"The world of protein acetylation","volume":"1864","author":"Drazic","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.arr.2026.103364_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41592-024-02480-7","article-title":"Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges","volume":"22","author":"Ewoldt","year":"2025","journal-title":"Nat. Methods"},{"key":"10.1016\/j.arr.2026.103364_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/1096-8628(20010101)98:1<92::AID-AJMG1009>3.0.CO;2-O","article-title":"Manifestations in four males with and an obligate carrier of the Lenz microphthalmia syndrome","volume":"98","author":"Forrester","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4939-6850-3_2","article-title":"DTNB-Based Quantification of In Vitro Enzymatic N-Terminal Acetyltransferase Activity","volume":"1574","author":"Foyn","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib27","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/mds.29793","article-title":"Cortical Myoclonus and Complex Paroxysmal Dyskinesias in a Patient with NAA15 Variant","volume":"39","author":"Freri","year":"2024","journal-title":"Mov. Disord."},{"key":"10.1016\/j.arr.2026.103364_bib28","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1126\/science.adg3297","article-title":"NAC controls cotranslational N-terminal methionine excision in eukaryotes","volume":"380","author":"Gamerdinger","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103364_bib29","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1128\/MCB.23.20.7403-7414.2003","article-title":"The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides","volume":"23","author":"Gautschi","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.biochi.2014.11.008","article-title":"N-terminal protein modifications: Bringing back into play the ribosome","volume":"114","author":"Giglione","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.arr.2026.103364_bib31","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1002\/ajmg.a.62351","article-title":"Confirmation of Ogden syndrome as an X-linked recessive fatal disorder due to a recurrent NAA10 variant and review of the literature","volume":"185","author":"Gogoll","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.arr.2026.103364_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113768","article-title":"HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana","volume":"43","author":"Gong","year":"2024","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103364_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101363","article-title":"N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate","volume":"297","author":"Gottlieb","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103364_bib34","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.str.2018.04.003","article-title":"Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK","volume":"26","author":"Gottlieb","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.arr.2026.103364_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-70279-5","article-title":"NAA40 and NAC cooperate in co-translational histone acetylation in humans","volume":"17","author":"Guan","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib36","article-title":"Ocular Manifestations of the NAA10-Related Syndrome","volume":"2019","author":"Gupta","year":"2019","journal-title":"Case Rep. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib37","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1038\/s41467-023-40224-x","article-title":"Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae","volume":"14","author":"Guzman","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib38","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1038\/s41467-024-49489-2","article-title":"N-terminal cysteine acetylation and oxidation patterns may define protein stability","volume":"15","author":"Heathcote","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/bs.mie.2025.06.019","article-title":"Purification and activity assays of N-terminal acetyltransferase D","volume":"718","author":"Ho","year":"2025","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.arr.2026.103364_bib40","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.aac9396","article-title":"De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies","volume":"350","author":"Homsy","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103364_bib41","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ccr.2010.11.010","article-title":"N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42\/Rac1 activity","volume":"19","author":"Hua","year":"2011","journal-title":"Cancer Cell."},{"key":"10.1016\/j.arr.2026.103364_bib42","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/onc.2012.82","article-title":"Protein N-terminal acetyltransferases in cancer","volume":"32","author":"Kalvik","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.arr.2026.103364_bib43","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.redox.2018.09.002","article-title":"FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1alpha","volume":"19","author":"Kang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.arr.2026.103364_bib44","article-title":"NAA10 as a New Prognostic Marker for Cancer Progression","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103364_bib45","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1038\/s41467-024-51964-9","article-title":"Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome","volume":"15","author":"Klein","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad091","article-title":"Spotlight on the 2022 ESC guideline management of ventricular arrhythmias and prevention of sudden cardiac death: 10 novel key aspects","volume":"25","author":"Konemann","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.arr.2026.103364_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25030580","article-title":"Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro","volume":"25","author":"Koppen","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2026.103364_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092631","article-title":"N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours","volume":"12","author":"Koufaris","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arr.2026.103364_bib49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2009.08.127","article-title":"Phosphorylation of ARD1 by IKK\u03b2 contributes to its destabilization and degradation","volume":"389","author":"Kuo","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000590","article-title":"ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway","volume":"3","author":"Kuo","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.arr.2026.103364_bib51","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/jnen\/nlad037","article-title":"NAA10 overexpression dictates distinct epigenetic, genetic, and clinicopathological characteristics in adult gliomas","volume":"82","author":"Le","year":"2023","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.arr.2026.103364_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molcel.2017.08.025","article-title":"The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting","volume":"68","author":"Lee","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.arr.2026.103364_bib53","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1172\/JCI42275","article-title":"hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing","volume":"120","author":"Lee","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.arr.2026.103364_bib54","first-page":"1","article-title":"N-alpha-acetyltransferase 10 (NAA10) in development: the role of NAA10","volume":"50","author":"Lee","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.arr.2026.103364_bib55","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41586-024-07846-7","article-title":"NAC guides a ribosomal multienzyme complex for nascent protein processing","volume":"633","author":"Lentzsch","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103364_bib56","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/s41588-019-0517-5","article-title":"The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy","volume":"51","author":"Lindeboom","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib57","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41467-022-28414-5","article-title":"Cotranslational N-degron masking by acetylation promotes proteome stability in plants","volume":"13","author":"Linster","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib58","doi-asserted-by":"crossref","first-page":"37002","DOI":"10.1074\/jbc.M111.282863","article-title":"Structure of a ternary Naa50p (NAT5\/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation","volume":"286","author":"Liszczak","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103364_bib59","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/nsmb.2636","article-title":"Molecular basis for N-terminal acetylation by the heterodimeric NatA complex","volume":"20","author":"Liszczak","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.mie.2023.02.024","article-title":"Using cell lysates to assess N-terminal acetyltransferase activity and impairment","volume":"686","author":"Lundekvam","year":"2023","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.arr.2026.103364_bib61","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41431-023-01368-y","article-title":"Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome","volume":"31","author":"Lyon","year":"2023","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186278","article-title":"Probing the interaction between NatA and the ribosome for co-translational protein acetylation","volume":"12","author":"Magin","year":"2017","journal-title":"PLoS. One"},{"key":"10.1016\/j.arr.2026.103364_bib63","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1074\/jbc.M115.709428","article-title":"The N-terminal Acetyltransferase Naa10\/ARD1 Does Not Acetylate Lysine Residues","volume":"291","author":"Magin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.arr.2026.103364_bib64","author":"Makwana","year":"2025","journal-title":"Cardiovasc. Manif. Manag. Recomm. Ogden Syndr. medRxiv"},{"key":"10.1016\/j.arr.2026.103364_bib65","doi-asserted-by":"crossref","first-page":"a018762","DOI":"10.1101\/cshperspect.a018762","article-title":"Writers and readers of histone acetylation: structure, mechanism, and inhibition","volume":"6","author":"Marmorstein","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21238973","article-title":"NAA10 p.(D10G) and NAA10 p.(L11R) Variants Hamper Formation of the NatA N-Terminal Acetyltransferase Complex","volume":"21","author":"McTiernan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103364_bib67","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41431-020-00728-2","article-title":"NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy","volume":"29","author":"McTiernan","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib68","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41467-025-55960-5","article-title":"Illuminating the impact of N-terminal acetylation: from protein to physiology","volume":"16","author":"McTiernan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib69","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12881-018-0559-z","article-title":"NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report","volume":"19","author":"McTiernan","year":"2018","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib70","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00439-021-02427-4","article-title":"Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N-terminal acetylation","volume":"141","author":"McTiernan","year":"2022","journal-title":"Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib71","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cjcpc.2022.10.001","article-title":"A Case of NAA10-related Syndrome With Prolonged QTc Treated With a Subcutaneous Implantable Cardioverter Defibrillator After Ventricular Fibrillation","volume":"1","author":"Mizuno","year":"2022","journal-title":"CJC Pediatr. Congenit. Heart Dis."},{"key":"10.1016\/j.arr.2026.103364_bib72","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/j.1460-2075.1989.tb03615.x","article-title":"Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast","volume":"8","author":"Mullen","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2026.103364_bib73","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/hmg\/ddu611","article-title":"Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects","volume":"24","author":"Myklebust","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib74","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/j.1460-2075.1992.tb05267.x","article-title":"ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity","volume":"11","author":"Park","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.arr.2026.103364_bib75","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1126\/science.aaa3844","article-title":"Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway","volume":"347","author":"Park","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.arr.2026.103364_bib76","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/jcb.21418","article-title":"Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes","volume":"103","author":"Polevoda","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.arr.2026.103364_bib77","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-2836(02)01269-X","article-title":"N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins","volume":"325","author":"Polevoda","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.arr.2026.103364_bib78","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ejhg.2014.150","article-title":"De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females","volume":"23","author":"Popp","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib79","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1080\/15548627.2017.1313945","article-title":"Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis","volume":"13","author":"Qian","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.arr.2026.103364_bib80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12881-019-0803-1","article-title":"A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly","volume":"20","author":"Ree","year":"2019","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111805","article-title":"Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells","volume":"22","author":"Ree","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103364_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0116-z","article-title":"Spotlight on protein N-terminal acetylation","volume":"50","author":"Ree","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.arr.2026.103364_bib83","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ajmg.a.61928","article-title":"Variants in NAA15 cause pediatric hypertrophic cardiomyopathy","volume":"185","author":"Ritter","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.arr.2026.103364_bib84","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ajhg.2011.05.017","article-title":"Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency","volume":"89","author":"Rope","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990\u20132015","volume":"70","author":"Roth","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.arr.2026.103364_bib86","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.csbj.2024.11.014","article-title":"Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation","volume":"23","author":"Saha","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.arr.2026.103364_bib87","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/humu.23001","article-title":"Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency","volume":"37","author":"Saunier","year":"2016","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.arr.2026.103364_bib88","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1158\/0008-5472.CAN-09-3258","article-title":"Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation","volume":"70","author":"Seo","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.arr.2026.103364_bib89","first-page":"881","article-title":"Sudden Cardiac Death as First Manifestation of Cardiovascular Disease: A Nationwide Study of 54,028 Deaths. JACC Clin Electrophysiol","volume":"11","author":"Skjelbred","year":"2025"},{"key":"10.1016\/j.arr.2026.103364_bib90","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/s41431-018-0136-0","article-title":"A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy","volume":"26","author":"Stove","year":"2018","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.arr.2026.103364_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910692","article-title":"Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates","volume":"22","author":"Van Damme","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103364_bib92","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.004580","article-title":"Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase","volume":"10","author":"Van Damme","year":"2011","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.arr.2026.103364_bib93","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1074\/mcp.M113.035402","article-title":"A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant","volume":"13","author":"Van Damme","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.arr.2026.103364_bib94","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s13104-018-3513-4","article-title":"Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae","volume":"11","author":"Varland","year":"2018","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.arr.2026.103364_bib95","doi-asserted-by":"crossref","DOI":"10.1063\/1.5037968","article-title":"A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues","volume":"2","author":"Visone","year":"2018","journal-title":"APL Bioeng."},{"key":"10.1016\/j.arr.2026.103364_bib96","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/eurjpc\/zwae384","article-title":"Temporal trend and attributable risk factors of cardiovascular disease burden for adults 55 years and older in 204 countries\/territories from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021","volume":"32","author":"Wang","year":"2025","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.arr.2026.103364_bib97","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCRESAHA.120.316966","article-title":"Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency","volume":"128","author":"Ward","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.arr.2026.103364_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15726","article-title":"Structural basis of HypK regulating N-terminal acetylation by the NatA complex","volume":"8","author":"Weyer","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib99","first-page":"895","article-title":"A case of intellectual disability with long QT syndrome by NAA10 gene variation","volume":"62","author":"Wu","year":"2024","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.arr.2026.103364_bib100","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200833","article-title":"Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes","volume":"41","author":"Wu","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.arr.2026.103364_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0098-x","article-title":"NAA10-related syndrome","volume":"50","author":"Wu","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.arr.2026.103364_bib102","doi-asserted-by":"crossref","DOI":"10.1038\/srep38508","article-title":"Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-alpha-Acetyltransferase 10 (Naa10)","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.arr.2026.103364_bib103","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.18632\/oncotarget.6458","article-title":"microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.arr.2026.103364_bib104","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1038\/ncomms6176","article-title":"NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2","volume":"5","author":"Yoon","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib105","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1038\/s41467-025-58539-2","article-title":"Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy","volume":"16","author":"Yoshinaga","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103364_bib106","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature12141","article-title":"De novo mutations in histone-modifying genes in congenital heart disease","volume":"498","author":"Zaidi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.arr.2026.103364_bib107","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/carcin\/bgu132","article-title":"Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis","volume":"35","author":"Zeng","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.arr.2026.103364_bib108","doi-asserted-by":"crossref","DOI":"10.3390\/cells14201596","article-title":"Drosophila models reveal NAT complex roles in heart development and enable functional validation of congenital heart disease variants","volume":"14","author":"Zhu","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.arr.2026.103364_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147866","article-title":"The role of N-acetyltransferases in cancers","volume":"892","author":"Zhu","year":"2024","journal-title":"Gene"}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:47:45Z","timestamp":1791647265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726003569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":109,"alternative-id":["S1568163726003569"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103364","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAA10 and NAA15 mutations in cardiovascular disorders: Recent advances and mechanistic insights","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103364"}}