{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:44:12Z","timestamp":1792053852566,"version":"4.4.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ageing Research Reviews"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.arr.2026.103391","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:51Z","timestamp":1791389571000},"page":"103391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Is there a role for senotherapeutics in the treatment of giant cell arteritis?"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-1410","authenticated-orcid":false,"given":"Chiara","family":"Marvisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Croci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41392-024-02046-1","article-title":"Metformin: decelerates biomarkers of aging clocks","volume":"9","author":"Abou Zaki","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/annrheumdis-2021-220955","article-title":"Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis","volume":"81","author":"Adriawan","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12017-026-08923-y","article-title":"SIRT1 activators as geroprotective agents in brain aging: mechanisms and therapeutic potential","volume":"28","author":"Alameen","year":"2026","journal-title":"NeuroMol. Med."},{"issue":"10","key":"10.1016\/j.arr.2026.103391_bib4","doi-asserted-by":"crossref","first-page":"14659","DOI":"10.1007\/s00210-026-05309-6","article-title":"Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline","volume":"399","author":"Alameen","year":"2026","journal-title":"Naunyn Schmiede Arch. Pharmacol."},{"issue":"20","key":"10.1016\/j.arr.2026.103391_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of biological importance of quercetin: a bioactive flavonoid","volume":"10","author":"Anand David","year":"2016","journal-title":"Pharmacogn. Rev."},{"issue":"10","key":"10.1016\/j.arr.2026.103391_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140273","article-title":"Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model","volume":"10","author":"Balasubramanian","year":"2015","journal-title":"PloS. One"},{"key":"10.1016\/j.arr.2026.103391_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.redox.2015.04.009","article-title":"Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells","volume":"5","author":"Banerjee","year":"2015","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.arr.2026.103391_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bdd.677","article-title":"Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats","volume":"30","author":"Barve","year":"2009","journal-title":"Biopharm. Drug. Dispos."},{"key":"10.1016\/j.arr.2026.103391_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2147\/OTT.S35360","article-title":"Systematic review of dasatinib in chronic myeloid leukemia","volume":"6","author":"Breccia","year":"2013","journal-title":"OncoTargets Ther."},{"issue":"2","key":"10.1016\/j.arr.2026.103391_bib10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3390\/ijms25020747","article-title":"Resveratrol for the management of human health: how far have we come? A systematic review of resveratrol clinical trials to highlight gaps and opportunities","volume":"25","author":"Brown","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.arr.2026.103391_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1221227","article-title":"Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives","volume":"10","author":"Chen","year":"2023","journal-title":"Front. Nutr."},{"issue":"8","key":"10.1016\/j.arr.2026.103391_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27082498","article-title":"Health benefits of quercetin in age-related diseases","volume":"27","author":"Deepika","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.arr.2026.103391_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/srep41539","article-title":"Quercetin inhibits inflammasome activation by interfering with ASC oligomerization and prevents interleukin-1 mediated mouse vasculitis","volume":"7","author":"Domiciano","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.arr.2026.103391_bib14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/annrheumdis-2012-201836","article-title":"Increased IL-17A expression in temporal artery lesions is a predictor of sustained response to glucocorticoid treatment in patients with giant-cell arteritis","volume":"72","author":"Esp\u00edgol-Frigol\u00e9","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/acel.12545","article-title":"Robust, universal biomarker assay to detect senescent cells in biological specimens","volume":"16","author":"Evangelou","year":"2017","journal-title":"Aging Cell."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-004600","article-title":"Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies","volume":"10","author":"Ferrigno","year":"2024","journal-title":"RMD Open."},{"issue":"10","key":"10.1016\/j.arr.2026.103391_bib17","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/art.24459","article-title":"Epidemiology of giant cell arteritis and polymyalgia rheumatica","volume":"61","author":"Gonzalez-Gay","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.arr.2026.103391_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.arr.2026.103391_bib19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10522-019-09825-2","article-title":"Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence","volume":"20","author":"Grabowska","year":"2019","journal-title":"Biogerontology"},{"key":"10.1016\/j.arr.2026.103391_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103151","article-title":"Neointimal myofibroblasts contribute to maintaining Th1\/Tc1 and Th17\/Tc17 inflammation in giant cell arteritis","volume":"142","author":"Greigert","year":"2024","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"issue":"17","key":"10.1016\/j.arr.2026.103391_bib22","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.cub.2017.07.033","article-title":"Unmasking transcriptional heterogeneity in senescent cells","volume":"27","author":"Hernandez-Segura","year":"2017","journal-title":"Curr. Biol. CB"},{"issue":"8","key":"10.1016\/j.arr.2026.103391_bib23","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/art.42138","article-title":"Global transcriptomic profiling identifies differential gene expression signatures between inflammatory and noninflammatory aortic aneurysms","volume":"74","author":"Hur","year":"2022","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/BOR.0000000000001051","article-title":"Giant cell arteritis: Update on pathogenesis and clinical implications","volume":"37","author":"Ibrahim","year":"2025","journal-title":"Curr. Opin. Rheumatol."},{"issue":"10","key":"10.1016\/j.arr.2026.103391_bib25","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/art.42525","article-title":"Indication of activated senescence pathways in the temporal arteries of patients with giant cell arteritis","volume":"75","author":"Jiemy","year":"2023","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"10.1016\/j.arr.2026.103391_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/1529-0131(199804)41:4<623::AID-ART9>3.0.CO;2-6","article-title":"Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis","volume":"41","author":"Kaiser","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.arr.2026.103391_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair."},{"issue":"2","key":"10.1016\/j.arr.2026.103391_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11357-009-9124-1","article-title":"Kaempferol modulates pro-inflammatory NF-\u03baB activation by suppressing advanced glycation endproducts-induced NADPH oxidase","volume":"32","author":"Kim","year":"2010","journal-title":"Age"},{"issue":"5","key":"10.1016\/j.arr.2026.103391_bib29","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41596-021-00505-5","article-title":"Algorithmic assessment of cellular senescence in experimental and clinical specimens","volume":"16","author":"Kohli","year":"2021","journal-title":"Nat. Protoc."},{"issue":"21","key":"10.1016\/j.arr.2026.103391_bib30","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1158\/1078-0432.CCR-16-0667","article-title":"Dasatinib reversibly disrupts endothelial vascular integrity by increasing non-muscle myosin II contractility in a ROCK-dependent manner","volume":"23","author":"Kreutzman","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.arr.2026.103391_bib31","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2022.72","article-title":"Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study","volume":"11","author":"Krishnakumar","year":"2022","journal-title":"J. Nutr. Sci."},{"issue":"11","key":"10.1016\/j.arr.2026.103391_bib32","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.arr.2026.103391_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2021.05.003","article-title":"Senolytics and senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases","volume":"171","author":"Lagoumtzi","year":"2021","journal-title":"Free. Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.arr.2026.103391_bib34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.18632\/aging.101787","article-title":"The curcumin analog EF24 is a novel senolytic agent","volume":"11","author":"Li","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.arr.2026.103391_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4793125","article-title":"Epigallocatechin gallate effectively affects senescence and anti-SASP via SIRT3 in 3T3-L1 preadipocytes in comparison with other bioactive substances","volume":"2020","author":"Lilja","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.arr.2026.103391_bib36","article-title":"Dasatinib and quercetin mitigate radiation-induced lung injury by eliminating senescent cells in a rat model","volume":"17","author":"Liu","year":"2026","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.arr.2026.103391_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.arr.2026.103391_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.958563","article-title":"Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging \u2013 from theory to practice","volume":"9","author":"Lu\u00eds","year":"2022","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.arr.2026.103391_bib39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1084\/jem.20030850","article-title":"Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis","volume":"199","author":"Ma-Krupa","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.arr.2026.103391_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jaut.2018.07.013","article-title":"mTOR pathway activation in large vessel vasculitis","volume":"94","author":"Maciejewski-Duval","year":"2018","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14060","article-title":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","volume":"23","author":"Mahoney","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103391_bib42","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-026-05416-4","article-title":"Pharmacological targeting of the senescence-associated secretory phenotype in atherosclerosis: therapeutic potential of senolytics and senomorphics","author":"Manni","year":"2026","journal-title":"Naunyn Schmiede Arch. Pharmacol. Publ. Online"},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11011-026-01874-0","article-title":"Beyond biochemical cascades: novel bio-mechanical and epigenetic paradigms of glial SASP in brain aging","volume":"41","author":"Manni","year":"2026","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.arr.2026.103391_bib44","article-title":"Cross-trait meta-analysis reveals a genetic link between inflammation and aging in giant cell arteritis","author":"Mart\u00ednez-Guti\u00e9rrez","year":"2025","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14361","article-title":"Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators","volume":"24","author":"Maurer","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103391_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105612","article-title":"A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer\u2019s disease","volume":"113","author":"Millar","year":"2025","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.arr.2026.103391_bib47","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/annrheumdis-2016-210070","article-title":"An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy","volume":"76","author":"Miyabe","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.arr.2026.103391_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/ar3358","article-title":"Giant cell arteritis: immune and vascular aging as disease risk factors","volume":"13","author":"Mohan","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK\/NF-\u03baB activation","volume":"12","author":"Moiseeva","year":"2013","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103391_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104481","article-title":"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability","volume":"90","author":"Nambiar","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.arr.2026.103391_bib51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/bs.apcsb.2023.02.020","article-title":"Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction","volume":"136","author":"Nehlin","year":"2023","journal-title":"Adv. Protein Chem. Struct. Biol."},{"issue":"9","key":"10.1016\/j.arr.2026.103391_bib52","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2217\/fon.11.81","article-title":"Ruxolitinib: A new JAK1\/2 inhibitor that offers promising options for treatment of myelofibrosis","volume":"7","author":"Ostojic","year":"2011","journal-title":"Future Oncol."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s40959-015-0008-5","article-title":"Tyrosine kinase inhibitor associated vascular toxicity in chronic myeloid leukemia","volume":"1","author":"Pasvolsky","year":"2015","journal-title":"Cardio-Oncology"},{"issue":"5","key":"10.1016\/j.arr.2026.103391_bib54","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/art.11388","article-title":"Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes","volume":"49","author":"Proven","year":"2003","journal-title":"Arthritis Care Res."},{"issue":"1","key":"10.1016\/j.arr.2026.103391_bib55","article-title":"Large-vessel vasculitis","volume":"7","author":"Pugh","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib56","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and health","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.arr.2026.103391_bib57","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1536\/ihj.47.795","article-title":"Revascularization of malignant coronary instent restenosis resulting from Takayasu\u2019s arteritis using sirolimus-eluting stents","volume":"47","author":"Sakai","year":"2006","journal-title":"Int. Heart J."},{"issue":"12","key":"10.1016\/j.arr.2026.103391_bib58","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/neurolint17120204","article-title":"Senotherapeutics for brain aging management","volume":"17","author":"Saliev","year":"2025","journal-title":"Neurol. Int."},{"issue":"4","key":"10.1016\/j.arr.2026.103391_bib59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra011913","article-title":"Polymyalgia rheumatica and giant-cell arteritis","volume":"347","author":"Salvarani","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.arr.2026.103391_bib60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.autrev.2017.05.014","article-title":"Recent advances in our understanding of giant cell arteritis pathogenesis","volume":"16","author":"Samson","year":"2017","journal-title":"Autoimmun. Rev."},{"issue":"9","key":"10.1016\/j.arr.2026.103391_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1332","article-title":"Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis","volume":"10","author":"Samson","year":"2021","journal-title":"Clin. Transl. Immunol."},{"issue":"7","key":"10.1016\/j.arr.2026.103391_bib62","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3390\/metabo12070639","article-title":"Reconnoitering the therapeutic role of curcumin in disease prevention and treatment: lessons learnt and future directions","volume":"12","author":"Sivani","year":"2022","journal-title":"Metabolites"},{"issue":"12","key":"10.1016\/j.arr.2026.103391_bib63","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.4049\/jimmunol.168.12.6165","article-title":"Role of IFN-\u03b3 in Th1 differentiation: IFN-\u03b3 regulates IL-18R\u03b1 expression by preventing the negative effects of IL-4 and by inducing\/maintaining IL-12 receptor \u03b22 expression","volume":"168","author":"Smeltz","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.arr.2026.103391_bib64","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jare.2021.12.009","article-title":"Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux","volume":"41","author":"Tai","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.arr.2026.103391_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111995","article-title":"Fisetin as a senotherapeutic agent: evidence and perspectives for age-related diseases","volume":"222","author":"Tavenier","year":"2024","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.arr.2026.103391_bib66","doi-asserted-by":"crossref","first-page":"27743","DOI":"10.3402\/pba.v5.27743","article-title":"The emerging role of senescent cells in tissue homeostasis and pathophysiology","volume":"5","author":"Tominaga","year":"2015","journal-title":"Pathobiol. Aging Age Relat. Dis."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib67","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/ard-2023-224467","article-title":"Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways","volume":"83","author":"Veroutis","year":"2024","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.arr.2026.103391_bib68","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/acel.12587","article-title":"Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism","volume":"16","author":"Wang","year":"2017","journal-title":"Aging Cell."},{"key":"10.1016\/j.arr.2026.103391_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112207","article-title":"Research progress on sirtuins family members and cell senescence","volume":"193","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.arr.2026.103391_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.843305","article-title":"Aging-related vascular inflammation: giant cell arteritis and neurological disorders","volume":"14","author":"Watanabe","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"399","key":"10.1016\/j.arr.2026.103391_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal3322","article-title":"The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged 1-Notch pathway","volume":"9","author":"Wen","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.arr.2026.103391_bib72","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clim.2019.02.007","article-title":"Cytokines, growth factors and proteases in medium and large vessel vasculitis","volume":"206","author":"Weyand","year":"2019","journal-title":"Clin. Immunol."},{"issue":"11","key":"10.1016\/j.arr.2026.103391_bib73","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.7150\/ijbs.96489","article-title":"Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2\/STAT3 signaling pathway","volume":"20","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.arr.2026.103391_bib74","article-title":"Curcumin and curcuma longa extract in the treatment of 10 types of autoimmune diseases: a systematic review and meta-analysis of 31 randomized controlled trials","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Ageing Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568163726003831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:48:25Z","timestamp":1792050505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568163726003831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":74,"alternative-id":["S1568163726003831"],"URL":"https:\/\/doi.org\/10.1016\/j.arr.2026.103391","relation":{},"ISSN":["1568-1637"],"issn-type":[{"value":"1568-1637","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there a role for senotherapeutics in the treatment of giant cell arteritis?","name":"articletitle","label":"Article Title"},{"value":"Ageing Research Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arr.2026.103391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103391"}}