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(Lausanne)"},{"key":"10.1016\/j.arr.2026.103417_bib73","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1016\/j.neuron.2023.06.013","article-title":"2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience","volume":"111","author":"Kumar","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.arr.2026.103417_bib74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/lifemedi\/lnac013","article-title":"Single-cell immune atlas for human aging and frailty","volume":"1","author":"Leng","year":"2022","journal-title":"Life Med."},{"key":"10.1016\/j.arr.2026.103417_bib75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.freeradbiomed.2022.12.084","article-title":"Intermittent fasting reverses the declining quality of aged oocytes","volume":"195","author":"Li","year":"2023","journal-title":"Free. Radic. Biol. 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