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Rev."},{"key":"10.1016\/j.arr.2026.103419_bib93","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019948","article-title":"Effects of aging on cardiac oxidative stress and transcriptional changes in pathways of reactive oxygen species generation and clearance","volume":"10","author":"Rizvi","year":"2021","journal-title":"J. Am. 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Am. Heart Assoc."},{"key":"10.1016\/j.arr.2026.103419_bib97","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1038\/s41467-025-58819-x","article-title":"Health octo tool matches personalized health with rate of aging","volume":"16","author":"Salimi","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.arr.2026.103419_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2026.103150","article-title":"Mitochondrial-nuclear crosstalk: A central axis in Alzheimer's disease","volume":"119","author":"Samantaray","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.arr.2026.103419_bib99","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.2337\/dc18-2356","article-title":"Effects of metformin therapy on coronary endothelial dysfunction in patients with prediabetes with stable angina and nonobstructive coronary artery stenosis: the CODYCE multicenter prospective study","volume":"42","author":"Sardu","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.arr.2026.103419_bib100","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000214752","article-title":"Circulating biomarkers of neurodegeneration and all-cause and dementia-specific mortality","volume":"106","author":"Sawyer","year":"2026","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2026.103419_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2026.117235","article-title":"Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer's disease heterogeneity","volume":"45","author":"Scheidemantel","year":"2026","journal-title":"Cell. Rep."},{"key":"10.1016\/j.arr.2026.103419_bib102","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1474-4422(18)30336-3","article-title":"Stroke-heart syndrome: clinical presentation and underlying mechanisms","volume":"17","author":"Scheitz","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.arr.2026.103419_bib103","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.exger.2016.06.003","article-title":"Preventive geriatrics the cross-talk between arterial and brain aging: a lifelong condition","volume":"87","author":"Scuteri","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.arr.2026.103419_bib104","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf095","article-title":"Comparative effectiveness of metformin versus sulfonylureas on exceptional longevity in women with type 2 diabetes: target trial emulation","volume":"80","author":"Shadyab","year":"2025","journal-title":"J. Gerontol. A Biol. Sci. Med. 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Alzheimers Dis."},{"key":"10.1016\/j.arr.2026.103419_bib114","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14374","article-title":"Arterial calcification in the heart-brain axis and cognitive performance over time","volume":"21","author":"Streiber","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.arr.2026.103419_bib115","doi-asserted-by":"crossref","first-page":"e1402","DOI":"10.1212\/WNL.0000000000200898","article-title":"Association of pace of aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia","volume":"99","author":"Sugden","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.arr.2026.103419_bib116","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1038\/s41467-022-34801-9","article-title":"A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. 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