{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:36:04Z","timestamp":1790231764515,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Atherosclerosis Society"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.arteri.2015.11.001","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T14:45:24Z","timestamp":1451400324000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Circulating PCSK9 in patients with type 2 diabetes and related metabolic disorders"],"prefix":"10.1016","volume":"28","author":[{"given":"Daiana","family":"Ibarretxe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Girona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Plana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cabr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raim\u00f3n","family":"Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Amig\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Guaita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Mallol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Heras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Masana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arteri.2015.11.001_bib0155","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.46.070177.004341","article-title":"The low-density lipoprotein pathway and its relation to atherosclerosis","volume":"46","author":"Goldstein","year":"1977","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.arteri.2015.11.001_bib0160","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.0335507100","article-title":"The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation","volume":"100","author":"Seidah","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arteri.2015.11.001_bib0165","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1194\/jlr.R026658","article-title":"The PCSK9 decade","volume":"53","author":"Lambert","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.arteri.2015.11.001_bib0170","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tibs.2008.06.005","article-title":"PCSK9 and LDL cholesterol: unravelling the target to design the bullet","volume":"33","author":"Costet","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.arteri.2015.11.001_bib0175","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1161\/ATVBAHA.111.240549","article-title":"Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels","volume":"32","author":"Chernogubova","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.atherosclerosis.2009.06.023","article-title":"Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles","volume":"208","author":"Norata","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arteri.2015.11.001_bib0185","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Abifadel","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.arteri.2015.11.001_bib0190","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arteri.2015.11.001_bib0195","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCGENETICS.108.828467","article-title":"Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study","volume":"2","author":"Huang","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.arteri.2015.11.001_bib0200","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1016\/j.jacc.2010.02.044","article-title":"PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses","volume":"55","author":"Benn","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0205","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1210\/jc.2009-0141","article-title":"Genetic and metabolic determinants of plasma PCSK9 levels","volume":"94","author":"Lakoski","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.arteri.2015.11.001_bib0210","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1373\/clinchem.2009.126987","article-title":"Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents","volume":"55","author":"Baass","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.arteri.2015.11.001_bib0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.atherosclerosis.2011.03.023","volume":"217","author":"Brouwers","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arteri.2015.11.001_bib0220","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.atherosclerosis.2011.07.098","article-title":"Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes","volume":"219","author":"Verges","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arteri.2015.11.001_bib0225","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1074\/jbc.M508582200","article-title":"Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c","volume":"281","author":"Costet","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.arteri.2015.11.001_bib0230","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1210\/en.2008-1281","article-title":"Importance of proprotein convertase subtilisin\/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors","volume":"150","author":"Persson","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.arteri.2015.11.001_bib0235","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/ATVBAHA.115.305688","article-title":"Role of insulin in the regulation of proprotein convertase subtilisin\/kexin type 9","volume":"35","author":"Miao","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0240","doi-asserted-by":"crossref","first-page":"12027","DOI":"10.1073\/pnas.1534923100","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"Horton","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arteri.2015.11.001_bib0245","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.febslet.2009.12.018","article-title":"PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities","volume":"584","author":"Mbikay","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.arteri.2015.11.001_bib0250","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bbrc.2009.10.138","article-title":"PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion","volume":"390","author":"Langhi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.arteri.2015.11.001_bib0255","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/CS20140832","article-title":"Circulating PCSK9 levels are positively correlated with NMR-assessed atherogenic dyslipidaemia in patients with high cardiovascular risk","volume":"128","author":"Guardiola","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.arteri.2015.11.001_bib0260","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.arteri.2015.11.001_bib0265","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ajh.2010.192","article-title":"Arterial stiffness, its assessment, prognostic value, and implications for treatment","volume":"24","author":"Adji","year":"2011","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.arteri.2015.11.001_bib0270","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2214\/AJR.07.2366","article-title":"Sonographic assessment of regional adiposity","volume":"189","author":"Vlachos","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0275","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.arteri.2015.11.001_bib0280","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1194\/jlr.D050120","article-title":"Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy","volume":"56","author":"Mallol","year":"2015","journal-title":"J Lipid Res"},{"key":"10.1016\/j.arteri.2015.11.001_bib0285","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-60327-411-1_20","article-title":"Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MassARRAY)","volume":"578","author":"Oeth","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0290","doi-asserted-by":"crossref","first-page":"e001937","DOI":"10.1161\/JAHA.115.001937","article-title":"Efficiency and safety of proprotein convertase subtilisin\/kexin 9 monoclonal antibody on hypercholesterolemia: a meta-analysis of 20 randomized controlled trials","volume":"4","author":"Li","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.arteri.2015.11.001_bib0295","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/ATVBAHA.112.250043","article-title":"Proprotein convertase subtilisin\/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor","volume":"32","author":"Sun","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.arteri.2015.11.001_bib0300","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/ATVBAHA.110.220988","article-title":"Circulating proprotein convertase subtilisin\/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue","volume":"31","author":"Roubtsova","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916815001576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916815001576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T14:20:47Z","timestamp":1537107647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0214916815001576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0214916815001576"],"URL":"https:\/\/doi.org\/10.1016\/j.arteri.2015.11.001","relation":{},"ISSN":["0214-9168"],"issn-type":[{"value":"0214-9168","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating PCSK9 in patients with type 2 diabetes and related metabolic disorders","name":"articletitle","label":"Article Title"},{"value":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arteri.2015.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Sociedad Espa\u00f1ola de Arteriosclerosis. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}