{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:37:23Z","timestamp":1770723443711,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.arteri.2016.05.007","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T20:32:14Z","timestamp":1466886734000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Homociste\u00edna plasm\u00e1tica, Lp(a) y marcadores de estr\u00e9s oxidativo en la vasculopat\u00eda perif\u00e9rica del paciente con diabetes tipo 2"],"prefix":"10.1016","volume":"28","author":[{"given":"Jose T.","family":"Real","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Folgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Molina Mendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Martinez-Herv\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Peiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Ascaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arteri.2016.05.007_bib0100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00125-011-2336-9","article-title":"Prevalence of diabetes mellitus and impaired glucose regulation in Spain: The Di@bet.es Study","volume":"55","author":"Soriguer","year":"2012","journal-title":"Diabetologia."},{"key":"10.1016\/j.arteri.2016.05.007_bib0105","doi-asserted-by":"crossref","unstructured":"Aronson D. Hyperglycemia and the pathobiology of diabetic complications. En: Fisman EZ, Tenenbaum A (eds): Cardiovascular Diabetology: Clinical, Metabolic and Inflammatory Facets. Adv Cardiol. Basel, Karger, 2008, vol. 45, pp 1-16.","DOI":"10.1159\/000115118"},{"key":"10.1016\/j.arteri.2016.05.007_bib0110","first-page":"S196","article-title":"Lower extremity arterial disease assessed by ankle brachial index in a middle age population of Africans Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"31","author":"Zheng","year":"2006","journal-title":"Am J Prev Med."},{"key":"10.1016\/j.arteri.2016.05.007_bib0115","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.CIR.102.10.1082","article-title":"Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies","volume":"102","author":"Danesh","year":"2000","journal-title":"Circulation."},{"key":"10.1016\/j.arteri.2016.05.007_bib0120","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.arteri.2016.05.007_bib0125","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycosilation end products: Sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.arteri.2016.05.007_bib0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000150649.39934.13","article-title":"Oxidative stress and vascular disease","volume":"25","author":"Madamanchi","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.arteri.2016.05.007_bib0135","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/01.ATV.0000149143.04821.eb","article-title":"Redox mechanisms in blood vessel","volume":"25","author":"Mueller","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.arteri.2016.05.007_bib0140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","article-title":"Biomarkers of oxidative damage in human disease","volume":"52","author":"Dalle-Donne","year":"2006","journal-title":"Clin Chem."},{"key":"10.1016\/j.arteri.2016.05.007_bib0145","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jdiacomp.2015.05.023","article-title":"Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects","volume":"29","author":"Mendez","year":"2015","journal-title":"J Diabetes Complicat."},{"key":"10.1016\/j.arteri.2016.05.007_bib0150","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2012.04.038","article-title":"Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: A rationale for increased efforts to understand its pathophysiology and develop targeted therapies","volume":"60","author":"Tsimikas","year":"2012","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.arteri.2016.05.007_bib0155","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1161\/ATVBAHA.112.255521","article-title":"Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: The EPIC-Norfolk prospective population study","volume":"32","author":"Gurdasani","year":"2012","journal-title":"Arteriocler Thromb Vasc Biol."},{"key":"10.1016\/j.arteri.2016.05.007_bib0160","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1111\/j.1538-7836.2003.00500.x","article-title":"Homocysteine levels are associated with the severity of peripheral arterial disease in type 2 diabetic patients","volume":"1","author":"Ciccarone","year":"2003","journal-title":"J Tromb Haemost."},{"key":"10.1016\/j.arteri.2016.05.007_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.18.1.133","article-title":"Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: A population-based study","volume":"18","author":"Hoogeveen","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.arteri.2016.05.007_bib0170","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1001\/jama.285.19.2481","article-title":"Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprorein (a) and standard cholesterol screening as predictors of peripheral arterial disease","volume":"285","author":"Ridker","year":"2001","journal-title":"JAMA."},{"key":"10.1016\/j.arteri.2016.05.007_bib0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diacare.19.3.257","article-title":"Oxidative stress and diabetic vascular complications","volume":"19","author":"Giugliano","year":"1996","journal-title":"Diabetes Care."},{"key":"10.1016\/j.arteri.2016.05.007_bib0180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01322333","article-title":"Lipid peroxidation and activity of antioxidant enzymes in diabetic rats","volume":"151","author":"Kakkar","year":"1995","journal-title":"Mol Cell Biochem."},{"key":"10.1016\/j.arteri.2016.05.007_bib0185","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.2337\/diacare.26.5.1589","article-title":"New insights on oxidative stress and diabetic complications may lead to a casual antioxidant therapy","volume":"26","author":"Ceriello","year":"2003","journal-title":"Diabetes Care."},{"key":"10.1016\/j.arteri.2016.05.007_bib0190","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1523-1755.2004.00465.x","article-title":"Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease","volume":"65","author":"Payson Oberg","year":"2004","journal-title":"Kidney Int."}],"container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916816300614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916816300614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T05:58:07Z","timestamp":1568095087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0214916816300614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0214916816300614"],"URL":"https:\/\/doi.org\/10.1016\/j.arteri.2016.05.007","relation":{},"ISSN":["0214-9168"],"issn-type":[{"value":"0214-9168","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homociste\u00edna plasm\u00e1tica, Lp(a) y marcadores de estr\u00e9s oxidativo en la vasculopat\u00eda perif\u00e9rica del paciente con diabetes tipo 2","name":"articletitle","label":"Article Title"},{"value":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arteri.2016.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Sociedad Espa\u00f1ola de Arteriosclerosis. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}