{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:36:12Z","timestamp":1793723772304,"version":"4.6.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.arteri.2020.11.001","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T02:18:37Z","timestamp":1613873917000},"page":"138-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["El rastreo masivo de datos es una segunda oportunidad para mejorar el manejo de los pacientes con fenotipo de hipercolesterolemia familiar"],"prefix":"10.1016","volume":"33","author":[{"given":"Alberto","family":"Zamora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Paluzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Garc\u00eda-Vilches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Alonso Gisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana In\u00e9s","family":"M\u00e9ndez Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Plana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e8lia","family":"Rodr\u00edguez-Borjabad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Ibarretxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Mart\u00edn-Urda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Masana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arteri.2020.11.001_bib0185","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.jacc.2020.03.057","article-title":"Nordestgaard. Worldwide Prevalence of Familial Hypercholesterolemia","volume":"75","author":"Sabina","year":"2020","journal-title":"JACC"},{"key":"10.1016\/j.arteri.2020.11.001_bib0190","first-page":"30252","article-title":"Diagnostic yield of sequencing familial hypercholesterolemia genes in individuals with primary hypercholesterolemia [published online ahead of print, 2020 Jul 10]","volume":"S1885\u20135857","author":"Lamiquiz-Moneo","year":"2020","journal-title":"Rev Esp Cardiol (Engl Ed)."},{"key":"10.1016\/j.arteri.2020.11.001_bib0195","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jacl.2017.05.012","article-title":"Familial hypercholesterolemia in a European Mediterranean population","volume":"11","author":"Zamora","year":"2017","journal-title":"J Clin Lipidol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(02)00330-1","article-title":"Review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia","volume":"168","author":"Marks","year":"2003","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0205","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.jacc.2020.03.057","article-title":"Nordestgaard Worldwide Prevalence of Familial Hypercholesterolemia","volume":"75","author":"Beheshti","year":"2020","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0210","first-page":"1346","article-title":"Clinical features and gaps in the management of probable familial hypercholesterolemia and cardiovascular disease","volume":"10","author":"Zafrir","year":"2017","journal-title":"Circ J."},{"key":"10.1016\/j.arteri.2020.11.001_bib0215","doi-asserted-by":"crossref","first-page":"407e420","DOI":"10.1093\/aje\/kwh236","article-title":"Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review","volume":"160","author":"Austin","year":"2004","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0220","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.atherosclerosis.2019.02.003","article-title":"Effect of lipid-lowering treatment in cardiovascular disease prevalence in familial hypercholesterolemia","volume":"284","author":"P\u00e9rez-Calahorra","year":"2019","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0225","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1093\/eurheartj\/ehn422","article-title":"Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: A prospective registry study","volume":"29","author":"Neil","year":"2008","journal-title":"Eur Heart J."},{"key":"10.1016\/j.arteri.2020.11.001_bib0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1476-511X-10-94","article-title":"Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART)","volume":"10","author":"Mata","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0235","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.recesp.2018.12.012","article-title":"Estimated Percentage of Patients With Stable Coronary Heart Disease Candidates for PCSK9 Inhibitors. Response","volume":"72","author":"Zamora","year":"2019","journal-title":"Rev Esp Cardiol (Engl Ed)."},{"key":"10.1016\/j.arteri.2020.11.001_bib0240","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jamacardio.2019.5173","article-title":"Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action","volume":"5","year":"2020","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0245","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1161\/CIRCULATIONAHA.117.032321","article-title":"Prevalence and Predictors of Cholesterol Screening Awareness, and Statin Treatment Among US Adults With Familial Hypercholesterolemia or Other Forms of Severe Dyslipidemia (1999-2014)","volume":"137","author":"Bucholz","year":"2018","journal-title":"Circulation."},{"key":"10.1016\/j.arteri.2020.11.001_bib0250","unstructured":"Sociedad Espa\u00f1ola de Arteriosclerosis. https:\/\/www.se-arteriosclerosis.org\/unidades-de-lipidos-sea#arian (Visitado el 13\/08\/2020)"},{"key":"10.1016\/j.arteri.2020.11.001_bib0255","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.amjcard.2008.06.056","article-title":"Comparison of genetic versus clinical diagnosis in familial hypercholesterolemia","volume":"102","author":"Civeira","year":"2008","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0260","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.atherosclerosis.2016.03.025","article-title":"Efficacy of clinical diagnostic criteria for familial hypercholesterolemia genetic testing in Poland","volume":"249","author":"Mickiewicz","year":"2016","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0265","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41746-019-0101-5","article-title":"Finding missed cases of familial hypercholesterolemia in health systems using machine learning","volume":"2","author":"Banda","year":"2019","journal-title":"NPJ Digit Med."},{"key":"10.1016\/j.arteri.2020.11.001_bib0270","first-page":"1210","article-title":"Simplified Canadian Definition for Familial Hypercholesterolemia","volume":"34","author":"Ruel","year":"2018","journal-title":"Can J Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0275","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.atherosclerosis.2018.05.021","article-title":"Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales","volume":"275","author":"Crosland","year":"2018","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0280","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/CIRCULATIONAHA.119.044795","article-title":"Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease","volume":"141","author":"Hu","year":"2020","journal-title":"Circulation."},{"key":"10.1016\/j.arteri.2020.11.001_bib0285","unstructured":"Eur Lex. Access to European Union Law. https:\/\/eur-lex.europa.eu\/legal-content\/ES\/TXT\/?uri=CELEX%3A32016R0679 (Consultada el 08\/08\/2020)"},{"key":"10.1016\/j.arteri.2020.11.001_bib0290","first-page":"11","article-title":"Effectiveness of early detection of diseases","volume":"30","author":"Vi\u00f1es","year":"2007","journal-title":"An Sist Sanit Navar."},{"key":"10.1016\/j.arteri.2020.11.001_bib0295","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ajmg.a.34368","article-title":"The evaluation of cascade testing forfamilial hypercholesterolemia","volume":"158","author":"Morris","year":"2012","journal-title":"Am J Med Genet A."},{"key":"10.1016\/j.arteri.2020.11.001_bib0300","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","volume":"41","author":"Mach","year":"2019","journal-title":"Eur Heart J."},{"key":"10.1016\/j.arteri.2020.11.001_bib0305","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.atherosclerosis.2018.08.013","article-title":"Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study","volume":"277","author":"Casula","year":"2018","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.atherosclerosissup.2017.07.004","article-title":"Detection of familial hypercholesterolemia in patients from a general practice data base","volume":"29","author":"Casula","year":"2017","journal-title":"Atheroscler Suppl."},{"key":"10.1016\/j.arteri.2020.11.001_bib0315","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1016\/S2468-2667(19)30061-1","article-title":"Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care","volume":"4","author":"Weng","year":"2019","journal-title":"Lancet Public Health."},{"key":"10.1016\/j.arteri.2020.11.001_bib0320","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.hlc.2007.06.005","article-title":"Detection of Familial Hypercholesterolaemia: A Major Treatment Gap in Preventative Cardiology","volume":"17","author":"Bates","year":"2008","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.arteri.2020.11.001_bib0325","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.jacc.2019.02.059","article-title":"Familial Hypercholesterolemia Among Young Adults With Myocardial Infarction","volume":"73","author":"Singh","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0330","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.atherosclerosis.2018.09.039","article-title":"Detecting familial hypercholesterolemia earlier in life by actively searching for affected children: The DECOPIN project","volume":"278","author":"Ibarretxe","year":"2018","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0335","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2019.11.028","article-title":"Reaching detection targets in familial hypercholesterolaemia: Comparison of identification strategies","volume":"293","author":"Wald","year":"2020","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0340","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.atherosclerosis.2017.05.013","article-title":"How many familial hypercholesterolemia patients are eligible for PCSK9 inhibition?","volume":"262","author":"Masana","year":"2017","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.arteri.2020.11.001_bib0345","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/jcm8071080","article-title":"Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients","volume":"8","author":"Masana","year":"2019","journal-title":"J Clin Med."},{"key":"10.1016\/j.arteri.2020.11.001_bib0350","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.recesp.2019.07.024","article-title":"Recomendaciones para mejorar el control lip\u00eddico Documento de consenso de la Sociedad Espa\u00f1ola de Cardiolog\u00eda","volume":"73","author":"Escobar","year":"2020","journal-title":"Rev Esp Cardiol."},{"key":"10.1016\/j.arteri.2020.11.001_bib0355","first-page":"128","article-title":"Indicaciones de los inhibidores de PCSK9 en la pr\u00e1ctica cl\u00ednica. Recomendaciones de la Sociedad Espa\u00f1ola de Arteriosclerosis (SEA), 2019","volume":"31","author":"Ascaso","year":"2019","journal-title":"Clin Investig Arterioscler."},{"key":"10.1016\/j.arteri.2020.11.001_bib0360","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.atherosclerosis.2019.06.905","article-title":"Toward a new clinical classification of patients with familial hypercholesterolemia: one perspective from Spain","volume":"287","author":"Masana","year":"2019","journal-title":"Atherosclerosis."}],"container-title":["Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916820301121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0214916820301121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:32:38Z","timestamp":1759325558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0214916820301121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0214916820301121"],"URL":"https:\/\/doi.org\/10.1016\/j.arteri.2020.11.001","relation":{},"ISSN":["0214-9168"],"issn-type":[{"value":"0214-9168","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"El rastreo masivo de datos es una segunda oportunidad para mejorar el manejo de los pacientes con fenotipo de hipercolesterolemia familiar","name":"articletitle","label":"Article Title"},{"value":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arteri.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedad Espa\u00f1ola de Arteriosclerosis. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}